CA2458313A1 - Zeacarotene colorant for food and pharmaceuticals - Google Patents

Zeacarotene colorant for food and pharmaceuticals Download PDF

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Publication number
CA2458313A1
CA2458313A1 CA002458313A CA2458313A CA2458313A1 CA 2458313 A1 CA2458313 A1 CA 2458313A1 CA 002458313 A CA002458313 A CA 002458313A CA 2458313 A CA2458313 A CA 2458313A CA 2458313 A1 CA2458313 A1 CA 2458313A1
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CA
Canada
Prior art keywords
zeacarotene
mixture
oil
dispersion
soluble
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002458313A
Other languages
French (fr)
Other versions
CA2458313C (en
Inventor
Markus Ivo Beck
Kurt Bernhard
Alfred Giger
Bruno Leuenberger
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DSM IP Assets BV
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Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2458313A1 publication Critical patent/CA2458313A1/en
Application granted granted Critical
Publication of CA2458313C publication Critical patent/CA2458313C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
    • A23L5/40—Colouring or decolouring of foods
    • A23L5/42—Addition of dyes or pigments, e.g. in combination with optical brighteners
    • A23L5/43—Addition of dyes or pigments, e.g. in combination with optical brighteners using naturally occurring organic dyes or pigments, their artificial duplicates or their derivatives
    • A23L5/44—Addition of dyes or pigments, e.g. in combination with optical brighteners using naturally occurring organic dyes or pigments, their artificial duplicates or their derivatives using carotenoids or xanthophylls
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286—Carthamus (distaff thistle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B61/00—Dyes of natural origin prepared from natural sources, e.g. vegetable sources

Abstract

The use of .alpha.-zeacarotene, .beta.-zeacarotene or a mixture of both as a colouring agent for food or pharmaceutical compositions. For addition to the food or pharmaceutical composition or otherwise incorporation therein during its preparation the zeacarotene (mixture) is generally first formulated to a solid or liquid colorant composition in the form of a stable water-soluble or -dispersible powder, an aqueous colloidal solution or oil-in-water dispersion of such a powder, an oil-in-water dispersion of the zeacarotene (mixture), or an oil-soluble dispersion of the zeacarotene (mixture) in a triglyceride. In a solid colorant composition the the zeacarotene (mixture) is generally finely dispersed in a matrix or carrier. Such colorant compositions may be prepared by homogenizing, in an aqueous or colloidal solution of a carrier and optionally one or more water-soluble excipients and/or adjuvants, a solution or dispersion of the zeacarotene (mixture) and optionally one or more fat-soluble excipients and/or adjuvants in a triglyceride or an organic solvent, or in a mixture of both triglyceride and organic solvent, and, if required, converting the so obtained dispersion into a solid composition. The colorant compositions, their processes of preparation and the food or pharmaceutical compositions which comprise the zeacarotene (mixture) as the colouring agent are further aspects of this invention.

Claims (23)

Claims
1. The use of .alpha.-zeacarotene or .beta.-zeacarotene or a mixture of .alpha.- and .beta.-zeacarotene in any relative proportion as a colouring agent for food products or pharmaceutical compositions.
2. The use according to claim 1, wherein the colouring agent is .alpha.-zeacarotene.
3. The use according to claim 1, wherein the colouring agent is .beta.-zeacarotene.
4. The use according to any one of claims 1 to 3, wherein the food products are beverages, dairy products, milk substitute products, sweet products, fruit preparations, fat-based products and low calorific food products, cereals and cereal products, snacks, soups, sauces, seasonings, tofu products and compounded foods which contain one or more of the above-mentioned food products, and the pharmaceutical compositions are tablets or capsules.
5. The use according to any one of claims 1 to 4, wherein the concentration of the .alpha.-zeacarotene, the .beta.-zeacarotene or the mixture of .alpha.- and .beta.-zeacarotene used as the colouring agent in the food product is from about 0.1 to about 500 ppm, preferably from about 1 to about 50 ppm, based on the total weight of the food product.
6. The use according to any one of claims 1 to 5, wherein the .alpha.-zeacarotene, the .beta.-zeacarotene or the mixture of .alpha.- and .beta.-zeacarotene has been added to the food product or pharmaceutical composition to be coloured, or otherwise incorporated in the food product or pharmaceutical composition during its preparation, in the form of a colorant composition which is a stable water-soluble or -dispersible powder containing the zeacarotene or zeacarotene mixture, an aqueous colloidal solution or oil-in-water dispersion of the aforementioned powder, an oil-in-water dispersion the zeacarotene or zeacarotene mixture, or an oil-soluble dispersion of the zeacarotene or zeacarotene mixture in a triglyceride.
7. A colorant composition for food products or pharmaceutical compositions, characterized in that it contains .alpha.-zeacarotene or .beta.-zeacarotene or a mixture of .alpha.- and .beta.-zeacarotene in any relative proportion as the colouring agent.
8. A colorant composition according to claim 7, which is a stable water-soluble or -dispersible powder containing the zeacarotene or zeacarotene mixture, an aqueous colloidal solution or oil-in-water dispersion of the aforementioned powder, an oil-in-water dispersion of the zeacarotene or zeacarotene mixture, or an oil-soluble dispersion of the zeacarotene or zeacarotene mixture in a triglyceride.
9. A colorant composition according to claim 8, which is a stable water-soluble or -dispersible powder, the amount of the zeacarotene or zeacarotene mixture being from about 0.1 to about 30 wt.% based on the total weight of the colorant composition.
10. A colorant composition according to claim 9, wherein the zeacarotene or zeacarotene mixture is finely dispersed in a matrix or carrier, preferably a matrix or carrier comprising one or more of a carbohydrate, a modified carbohydrate, a protein, a modified protein or any mixture of two or more of these.
11. A colorant composition according to claim 10, wherein the matrix or carrier, of which at least a part can be a protective colloid, is selected from a polysaccharide gum, a modified food starch, a pectin, a maltodextrin, a protein, a ligninsulphonate and any mixture of these substances.
12. A colorant composition according to claim 11, wherein the matrix or carrier is selected from sodium octenyl succinyl starch as the modified food starch and a gelatin as the protein.
13. A colorant composition according to any one of claims 7 to 12, wherein the composition, in solid or liquid form as the case may be, (further) contains one or more excipients and/or adjuvants selected from one or more each of mono- di-, oligo-and polysaccharides, triglycerides, water-soluble antioxidants, fat-soluble antioxidants and, solely in the case of solid compositions, additionally an anti-caking agent.
14. A colorant composition according to claim 13, wherein the mono- di-, oligo-and polysaccharides are selected from sucrose, invert sugar, glucose, fructose, lactose, maltose, a sugar alcohol, starch, a starch hydrolysate and glucose syrup.
15. A colorant composition according to claim 14, wherein the starch hydrolysate is a dextrin or a maltodextrin having the range of 5 - 65 dextrose equivalents, and the glucose syrup has the range of 20 - 95 dextrose equivalents.
16. A colorant composition according to any one of claims 8 and 13 to 15, wherein the triglyceride is a vegetable oil or fat, preferably corn oil, sunflower oil, soybean oil, safflower oil, rape seed oil, peanut oil, palm oil, palm kernel oil, cotton seed oil or coconut oil.
17. A colorant composition according to any one of claims 13 to 16, wherein the water-soluble antioxidant is ascorbic acid or a salt thereof, preferably sodium ascorbate, and the fat-soluble antioxidant is a tocopherol, butylated hydroxytoluene;
butylated hydroxyanisole; propyl gallate; tert butyl hydroxyquinoline; or an ascorbic acid ester of a fatty acid, preferably ascorbyl palmitate or stearate.
18. A colorant composition according to any one of claims 13 to 17, wherein the anti-caking agent is silicic acid.
19. A process for preparing a colorant composition for food products or pharmaceutical compositions as claimed in any one of claims 7 to 8, characterized by homogenizing, in an aqueous or colloidal solution of a carrier and optionally one or more water-soluble excipients and/or adjuvants, a solution or dispersion of the zeacarotene or zeacarotene mixture and optionally one or more fat-soluble excipients and/or adjuvants in a triglyceride or an organic solvent, or in a mixture of both triglyceride and organic solvent, and, if required, converting the so obtained dispersion into a solid composition.
24. A process according to claim 19, characterized by preparing a solution or dispersion of the zeacarotene or zeacarotene mixture and an oil-soluble antioxidant in a triglyceride and optionally, an organic solvent, emulsifying the resulting oil-based solution or dispersion in an aqueous solution prepared from a protective hydrocolloid or carrier, a carbohydrate and, optionally, a water-soluble antioxidant; if required removing the organic solvent from the emulsion, drying the emulsion in a manner known per se, and finally separating the dried particles.
21. A process for preparing a colorant composition for food products or pharmaceutical compositions as claimed in any one of claims 7, 8 and 13 to 17 and which is a suspension of finely divided the zeacarotene or zeacarotene mixture in a triglyceride, characterized by introducing the zeacarotene or zeacarotene mixture and optionally one or more fat-soluble excipients and/or adjuvants in a triglyceride, affording an oil-miscible dispersion of the zeacarotene or zeacarotene mixture in the triglyceride, and milling the dispersion, e.g by ball-milling, thereby converting said dispersion into the desired suspension of finely divided zeacarotene or zeacarotene mixture in the triglyceride.
22. A food product or pharmaceutical composition, especially a beverage, a dairy product, a mills substitute product, a sweet product, a fruit preparation, a fat-based product, a low calorific food product, a cereal, a cereal product, a snack, a soup, a sauce, seasoning, a tofu. product or a compounded food which contain one or more of the above-mentioned food products, or, respectively; tablets or capsules, characterized by comprising .alpha.-zeacarotene or .beta.-zeacaroten or a mixture of .alpha.- and .beta.-zeacarotene in any relative proportion as a colouring agent in an amount sufficient to impart a yellow to greenish-yellow colour to the food product or pharmaceutical composition.
23. A food product according to claim 22, wherein the concentration of the zeacarotene or zeacarotene mixture used as the colouring agent is from about 0.1 to about 500 ppm, preferably from about 1 to about 50 ppm, based on the total weight of the food product.
CA2458313A 2001-09-13 2002-09-04 Zeacarotene colorant for food and pharmaceuticals Expired - Fee Related CA2458313C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP01121981.3 2001-09-13
EP01121981 2001-09-13
EP02001968 2002-02-04
EP02001968.3 2002-02-04
PCT/EP2002/009913 WO2003022071A2 (en) 2001-09-13 2002-09-04 Colorant for food and pharmaceuticals

Publications (2)

Publication Number Publication Date
CA2458313A1 true CA2458313A1 (en) 2003-03-20
CA2458313C CA2458313C (en) 2011-06-28

Family

ID=26076711

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2458313A Expired - Fee Related CA2458313C (en) 2001-09-13 2002-09-04 Zeacarotene colorant for food and pharmaceuticals

Country Status (14)

Country Link
US (1) US20050008746A1 (en)
EP (1) EP1427295B1 (en)
JP (1) JP4351528B2 (en)
KR (1) KR20050025122A (en)
CN (1) CN1278626C (en)
AT (1) ATE377954T1 (en)
AU (1) AU2002339495B2 (en)
BR (1) BR0212503A (en)
CA (1) CA2458313C (en)
DE (1) DE60223569T2 (en)
ES (1) ES2294174T3 (en)
IN (1) IN2004CH00530A (en)
MX (1) MX253134B (en)
WO (1) WO2003022071A2 (en)

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CA2635496A1 (en) * 2005-11-14 2007-05-24 Peter D. Winch Novel colored solutions of injectable drugs and their pharmaceutically acceptable salts
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JP6316182B2 (en) 2014-12-19 2018-04-25 富士フイルム株式会社 Liposome production method and liposome production apparatus
CN105581250A (en) * 2015-12-22 2016-05-18 广西绿娃农业投资有限公司 Colorful rice dumpling and making method thereof
DE102015122672A1 (en) * 2015-12-23 2017-06-29 Brauns-Heitmann Gmbh & Co. Kg Powdered egg dye composition
AU2017242919B2 (en) * 2016-04-01 2020-03-26 Dsm Ip Assets B.V. New tablettable formulation of lutein and/or zeaxanthin
CN107903197B (en) * 2017-12-22 2018-12-14 蓝星安迪苏南京有限公司 The stabilizer for preparing and storing for 3- methylthiopropionaldehyde
EP4057835A1 (en) * 2019-11-15 2022-09-21 Basf Se Food additives and methods for preparing the same
EP4259603A1 (en) * 2021-12-28 2023-10-18 Innobio Corporation Limited Carotenoid preparations, preparation methods, and application thereof
CN114680325B (en) * 2022-04-25 2022-11-11 武汉星辰现代生物工程有限公司 Beta-carotene nanoemulsion and preparation method and application thereof

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Also Published As

Publication number Publication date
JP2005505645A (en) 2005-02-24
WO2003022071A2 (en) 2003-03-20
ES2294174T3 (en) 2008-04-01
EP1427295A2 (en) 2004-06-16
ATE377954T1 (en) 2007-11-15
EP1427295B1 (en) 2007-11-14
DE60223569T2 (en) 2008-09-18
JP4351528B2 (en) 2009-10-28
US20050008746A1 (en) 2005-01-13
WO2003022071A3 (en) 2003-08-28
DE60223569D1 (en) 2007-12-27
CN1553776A (en) 2004-12-08
MXPA04002268A (en) 2005-03-07
CN1278626C (en) 2006-10-11
CA2458313C (en) 2011-06-28
BR0212503A (en) 2004-08-24
MX253134B (en) 2008-01-08
IN2004CH00530A (en) 2005-12-23
KR20050025122A (en) 2005-03-11
AU2002339495B2 (en) 2008-08-21

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