CA2455805A1 - Composes et procedes concernant l'utilisation d'agents therapeutiques dans la prevention de complications diabetiques - Google Patents
Composes et procedes concernant l'utilisation d'agents therapeutiques dans la prevention de complications diabetiques Download PDFInfo
- Publication number
- CA2455805A1 CA2455805A1 CA002455805A CA2455805A CA2455805A1 CA 2455805 A1 CA2455805 A1 CA 2455805A1 CA 002455805 A CA002455805 A CA 002455805A CA 2455805 A CA2455805 A CA 2455805A CA 2455805 A1 CA2455805 A1 CA 2455805A1
- Authority
- CA
- Canada
- Prior art keywords
- diabetic
- diabetes
- patient
- deoxyfructose
- glycated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 title claims abstract 21
- 230000001225 therapeutic effect Effects 0.000 title claims 6
- 208000002249 Diabetes Complications Diseases 0.000 title claims 2
- 206010012655 Diabetic complications Diseases 0.000 title claims 2
- 150000001875 compounds Chemical class 0.000 title 1
- 206010012601 diabetes mellitus Diseases 0.000 claims abstract 26
- 239000012472 biological sample Substances 0.000 claims abstract 11
- 230000001575 pathological effect Effects 0.000 claims abstract 11
- OXFWZSUJNURRMW-NTSWFWBYSA-N 3-deoxy-keto-D-fructose Chemical compound OC[C@@H](O)[C@@H](O)CC(=O)CO OXFWZSUJNURRMW-NTSWFWBYSA-N 0.000 claims abstract 10
- ZGCHLOWZNKRZSN-NTSWFWBYSA-N 3-deoxyglucosone Chemical compound OC[C@@H](O)[C@@H](O)CC(=O)C=O ZGCHLOWZNKRZSN-NTSWFWBYSA-N 0.000 claims abstract 9
- UHPMJDGOAZMIID-UHFFFAOYSA-N 3-deoxyglucosone Natural products OCC1OC(O)C(=O)CC1O UHPMJDGOAZMIID-UHFFFAOYSA-N 0.000 claims abstract 9
- 208000024891 symptom Diseases 0.000 claims abstract 3
- 208000007342 Diabetic Nephropathies Diseases 0.000 claims 3
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 3
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 3
- 208000033679 diabetic kidney disease Diseases 0.000 claims 3
- BFSYFTQDGRDJNV-AYHFEMFVSA-N fructosyllysine Chemical compound OC(=O)[C@@H](N)CCCCNCC(=O)[C@@H](O)[C@H](O)[C@H](O)CO BFSYFTQDGRDJNV-AYHFEMFVSA-N 0.000 claims 3
- 230000000977 initiatory effect Effects 0.000 claims 3
- 210000002700 urine Anatomy 0.000 claims 3
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 2
- 239000004472 Lysine Substances 0.000 claims 2
- 239000013060 biological fluid Substances 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 2
- 230000037213 diet Effects 0.000 claims 2
- 235000005911 diet Nutrition 0.000 claims 2
- 235000013305 food Nutrition 0.000 claims 2
- 108091005996 glycated proteins Proteins 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 208000032170 Congenital Abnormalities Diseases 0.000 claims 1
- 206010010356 Congenital anomaly Diseases 0.000 claims 1
- 206010063547 Diabetic macroangiopathy Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 230000007698 birth defect Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 235000021485 packed food Nutrition 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/794,433 | 1997-02-05 | ||
| US08/794,433 US6004958A (en) | 1997-02-05 | 1997-02-05 | Compounds and methods for therapeutic intervention in preventing diabetic complications and procedures for assessing a diabetic's risk of developing complications and determining the efficacy of therapeutic intervention |
| CA002279428A CA2279428C (fr) | 1997-02-05 | 1998-02-05 | Composes et procedes concernant l'utilisation d'agents therapeutiques dans la prevention de complications diabetiques |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002279428A Division CA2279428C (fr) | 1997-02-05 | 1998-02-05 | Composes et procedes concernant l'utilisation d'agents therapeutiques dans la prevention de complications diabetiques |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2455805A1 true CA2455805A1 (fr) | 1998-08-06 |
| CA2455805C CA2455805C (fr) | 2011-05-10 |
Family
ID=32094412
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2455805A Expired - Fee Related CA2455805C (fr) | 1997-02-05 | 1998-02-05 | Composes et procedes concernant l'utilisation d'agents therapeutiques dans la prevention de complications diabetiques |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2455805C (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2664606A1 (fr) * | 2012-04-25 | 2013-11-20 | Ueno Fine Chemicals Industry, Ltd. | Inhibiteur de la production de produits terminaux de glycation avancée |
-
1998
- 1998-02-05 CA CA2455805A patent/CA2455805C/fr not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2664606A1 (fr) * | 2012-04-25 | 2013-11-20 | Ueno Fine Chemicals Industry, Ltd. | Inhibiteur de la production de produits terminaux de glycation avancée |
| EP2664606B1 (fr) | 2012-04-25 | 2016-09-14 | Ueno Fine Chemicals Industry, Ltd. | Inhibiteur de la production de produits terminaux de glycation avancée |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2455805C (fr) | 2011-05-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20130205 |