CA2438891A1 - Method for preparing optically active dihydropyrones - Google Patents

Method for preparing optically active dihydropyrones Download PDF

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Publication number
CA2438891A1
CA2438891A1 CA002438891A CA2438891A CA2438891A1 CA 2438891 A1 CA2438891 A1 CA 2438891A1 CA 002438891 A CA002438891 A CA 002438891A CA 2438891 A CA2438891 A CA 2438891A CA 2438891 A1 CA2438891 A1 CA 2438891A1
Authority
CA
Canada
Prior art keywords
optically active
preparing optically
dihydropyrones
active dihydropyrones
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002438891A
Other languages
French (fr)
Other versions
CA2438891C (en
Inventor
Burkhard Jaeger
Markus Sauter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2438891A1 publication Critical patent/CA2438891A1/en
Application granted granted Critical
Publication of CA2438891C publication Critical patent/CA2438891C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrane Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

The invention relates to a new process for preparing optically active dihydropyrones, new intermediate products which may be obtained by this synthesis, and their use as starting compounds in the preparation of pharmaceutically active compounds.
CA002438891A 2001-02-22 2002-02-14 Method for preparing optically active dihydropyrones Expired - Fee Related CA2438891C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10108470.6 2001-02-22
DE10108470A DE10108470A1 (en) 2001-02-22 2001-02-22 Process for the production of optically active dihydropyrones
PCT/EP2002/001534 WO2002068404A1 (en) 2001-02-22 2002-02-14 Method for producing optically active dihydropyrones

Publications (2)

Publication Number Publication Date
CA2438891A1 true CA2438891A1 (en) 2002-09-06
CA2438891C CA2438891C (en) 2009-09-29

Family

ID=7675072

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002438891A Expired - Fee Related CA2438891C (en) 2001-02-22 2002-02-14 Method for preparing optically active dihydropyrones

Country Status (8)

Country Link
EP (1) EP1373241B1 (en)
JP (1) JP4070608B2 (en)
AT (1) ATE314358T1 (en)
CA (1) CA2438891C (en)
DE (2) DE10108470A1 (en)
ES (1) ES2254667T3 (en)
MX (1) MXPA03007352A (en)
WO (1) WO2002068404A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10257761A1 (en) 2002-12-10 2004-06-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg Preparation of optically active 5-hydroxy-3-ketoalkanoic acid ester derivatives used as intermediates for drugs, especially tipranavir, by optical resolution of racemate by preparative high performance liquid chromatography

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2096877B1 (en) * 1970-07-09 1973-08-10 Hexachimie
IT1208109B (en) * 1983-11-23 1989-06-06 Alfa Chem Ital PROCEDURE FOR THE OPTICAL RESOLUTION OF ARYLPROPIONIC ACIDS
SI1142887T1 (en) * 1993-11-19 2004-08-31 Parke, Davis & Company 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents
IL129871A (en) * 1994-05-06 2003-11-23 Pharmacia & Upjohn Inc Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections
RU2223958C2 (en) * 1997-09-11 2004-02-20 Фармация Энд Апджон Компани New method for preparing protease inhibitor
AU762349B2 (en) * 1998-11-04 2003-06-26 Pharmacia & Upjohn Company Method for improving the pharmacokinetics of tipranavir

Also Published As

Publication number Publication date
MXPA03007352A (en) 2003-12-04
ATE314358T1 (en) 2006-01-15
DE10108470A1 (en) 2002-09-05
EP1373241A1 (en) 2004-01-02
EP1373241B1 (en) 2005-12-28
ES2254667T3 (en) 2006-06-16
JP2004522785A (en) 2004-07-29
WO2002068404A1 (en) 2002-09-06
CA2438891C (en) 2009-09-29
DE50205442D1 (en) 2006-02-02
JP4070608B2 (en) 2008-04-02

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20160215