CA2438874A1 - Fluorinated trienes and their use as rxr modulators - Google Patents
Fluorinated trienes and their use as rxr modulators Download PDFInfo
- Publication number
- CA2438874A1 CA2438874A1 CA002438874A CA2438874A CA2438874A1 CA 2438874 A1 CA2438874 A1 CA 2438874A1 CA 002438874 A CA002438874 A CA 002438874A CA 2438874 A CA2438874 A CA 2438874A CA 2438874 A1 CA2438874 A1 CA 2438874A1
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- CA
- Canada
- Prior art keywords
- optionally substituted
- alkyl
- aryl
- methyl
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- -1 difluorornethyl Chemical group 0.000 claims description 101
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 93
- 125000003118 aryl group Chemical group 0.000 claims description 77
- 150000003839 salts Chemical class 0.000 claims description 54
- 125000001072 heteroaryl group Chemical group 0.000 claims description 46
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 46
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27580801P | 2001-03-14 | 2001-03-14 | |
| US60/275,808 | 2001-03-14 | ||
| PCT/US2002/007718 WO2002072528A1 (en) | 2001-03-14 | 2002-03-12 | Fluorinated trienes and their use as rxr modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2438874A1 true CA2438874A1 (en) | 2002-09-19 |
Family
ID=23053886
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002438874A Abandoned CA2438874A1 (en) | 2001-03-14 | 2002-03-12 | Fluorinated trienes and their use as rxr modulators |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20040248919A1 (https=) |
| EP (1) | EP1368296A1 (https=) |
| JP (1) | JP2004526725A (https=) |
| AU (1) | AU2002255732B2 (https=) |
| CA (1) | CA2438874A1 (https=) |
| MX (1) | MXPA03008229A (https=) |
| WO (1) | WO2002072528A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE158816T1 (de) | 1990-11-26 | 1997-10-15 | Genetics Inst | Expression von pace in wirtszellen und verfahren zu dessen verwendung |
| MXPA04000613A (es) * | 2001-07-20 | 2004-05-05 | Ligand Pharm Inc | DERIVADOS DE aCIDO PIRIDINILO Y PIRIMIDILTRIENOICO COMO MODULADORES DE RECEPTOR DE RETINOIDE X. |
| GB0308335D0 (en) | 2003-04-10 | 2003-05-14 | Novartis Ag | Organic compounds |
| US6887896B1 (en) * | 2003-10-29 | 2005-05-03 | Allergan, Inc. | 7-[(7-Alkoxy)-chrom-3-en-6-yl]-heptatrienoic acid and 7-[(3-alkoxy)-5,6-dihydronaphthalen-2-yl]-heptatrienoic acid derivatives having serum glucose reducing activity |
| CN1882327A (zh) | 2003-11-19 | 2006-12-20 | 症变治疗公司 | 含磷的新的拟甲状腺素药 |
| MX2007014502A (es) | 2005-05-26 | 2008-02-07 | Metabasis Therapeutics Inc | Tiromimeticos para el tratamiento de enfermedades del higado graso. |
| WO2009035673A1 (en) | 2007-09-12 | 2009-03-19 | Trustees Of Columbia University In The City Of Newyork | Compositions and methods for treating macular degeneration |
| JP6723752B2 (ja) * | 2015-02-10 | 2020-07-15 | 公益財団法人相模中央化学研究所 | 二次電池用電解液 |
| JP2020500199A (ja) | 2016-11-21 | 2020-01-09 | バイキング・セラピューティクス・インコーポレイテッド | グリコーゲン蓄積症の治療方法 |
| AU2018280118B2 (en) | 2017-06-05 | 2021-07-15 | Viking Therapeutics, Inc. | Compositions for the treatment of fibrosis |
| ES3053674T3 (en) | 2018-03-22 | 2026-01-23 | Viking Therapeutics Inc | Crystalline forms and methods of producing crystalline forms of a compound |
| WO2020117962A1 (en) | 2018-12-05 | 2020-06-11 | Viking Therapeutics, Inc. | Compositions for the treatment of fibrosis and inflammation |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5071773A (en) * | 1986-10-24 | 1991-12-10 | The Salk Institute For Biological Studies | Hormone receptor-related bioassays |
| US4981784A (en) * | 1987-12-02 | 1991-01-01 | The Salk Institute For Biological Studies | Retinoic acid receptor method |
| US5977125A (en) * | 1994-10-31 | 1999-11-02 | Eisai Co., Ltd. | Mono-or polyenic carboxylic acid derivatives |
| CA2204616C (en) * | 1995-09-18 | 2002-12-17 | Ranjan Mukherjee | Ppar gamma antagonists for treating obesity |
| WO1997012853A1 (en) * | 1995-10-06 | 1997-04-10 | Ligand Pharmaceuticals Incorporated | Dimer-selective rxr modulators and methods for their use |
| AU9556298A (en) * | 1998-11-03 | 2000-05-22 | Ligand Pharmaceuticals Incorporated | Trienoic retinoid compounds as retinoic acid receptor antagonists |
| AU762492B2 (en) * | 1999-03-08 | 2003-06-26 | Basilea Pharmaceutica Ag | Retinoid antagonists and use thereof |
| AU7586600A (en) * | 1999-09-14 | 2001-04-17 | Ligand Pharmaceuticals Incorporated | Rxr modulators with improved pharmacologic profile |
| MXPA04000613A (es) * | 2001-07-20 | 2004-05-05 | Ligand Pharm Inc | DERIVADOS DE aCIDO PIRIDINILO Y PIRIMIDILTRIENOICO COMO MODULADORES DE RECEPTOR DE RETINOIDE X. |
-
2002
- 2002-03-12 EP EP02725147A patent/EP1368296A1/en not_active Withdrawn
- 2002-03-12 MX MXPA03008229A patent/MXPA03008229A/es active IP Right Grant
- 2002-03-12 US US10/471,383 patent/US20040248919A1/en not_active Abandoned
- 2002-03-12 CA CA002438874A patent/CA2438874A1/en not_active Abandoned
- 2002-03-12 JP JP2002571445A patent/JP2004526725A/ja active Pending
- 2002-03-12 WO PCT/US2002/007718 patent/WO2002072528A1/en not_active Ceased
- 2002-03-12 AU AU2002255732A patent/AU2002255732B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002255732B2 (en) | 2006-03-09 |
| US20040248919A1 (en) | 2004-12-09 |
| MXPA03008229A (es) | 2004-11-12 |
| EP1368296A1 (en) | 2003-12-10 |
| JP2004526725A (ja) | 2004-09-02 |
| WO2002072528A1 (en) | 2002-09-19 |
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| Date | Code | Title | Description |
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| EEER | Examination request | ||
| FZDE | Dead |