CA2438874A1 - Fluorinated trienes and their use as rxr modulators - Google Patents
Fluorinated trienes and their use as rxr modulators Download PDFInfo
- Publication number
- CA2438874A1 CA2438874A1 CA002438874A CA2438874A CA2438874A1 CA 2438874 A1 CA2438874 A1 CA 2438874A1 CA 002438874 A CA002438874 A CA 002438874A CA 2438874 A CA2438874 A CA 2438874A CA 2438874 A1 CA2438874 A1 CA 2438874A1
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- CA
- Canada
- Prior art keywords
- optionally substituted
- alkyl
- aryl
- methyl
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- -1 difluorornethyl Chemical group 0.000 claims description 101
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 93
- 125000003118 aryl group Chemical group 0.000 claims description 77
- 150000003839 salts Chemical class 0.000 claims description 54
- 125000001072 heteroaryl group Chemical group 0.000 claims description 46
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 46
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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| US27580801P | 2001-03-14 | 2001-03-14 | |
| US60/275,808 | 2001-03-14 | ||
| PCT/US2002/007718 WO2002072528A1 (en) | 2001-03-14 | 2002-03-12 | Fluorinated trienes and their use as rxr modulators |
Publications (1)
| Publication Number | Publication Date |
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| CA2438874A1 true CA2438874A1 (en) | 2002-09-19 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002438874A Abandoned CA2438874A1 (en) | 2001-03-14 | 2002-03-12 | Fluorinated trienes and their use as rxr modulators |
Country Status (7)
| Country | Link |
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| US (1) | US20040248919A1 (cg-RX-API-DMAC10.html) |
| EP (1) | EP1368296A1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP2004526725A (cg-RX-API-DMAC10.html) |
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| MX (1) | MXPA03008229A (cg-RX-API-DMAC10.html) |
| WO (1) | WO2002072528A1 (cg-RX-API-DMAC10.html) |
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| EP0785273A1 (en) | 1990-11-26 | 1997-07-23 | Genetics Institute, Inc. | Paired basic amino acid converting enzyme and DNA sequence encoding it |
| CA2452541A1 (en) * | 2001-07-20 | 2003-01-30 | Eli Lilly And Company | (pyridinyl and pyrimidyl) trienoic acid derivatives as retinoid x receptor modulators |
| GB0308335D0 (en) | 2003-04-10 | 2003-05-14 | Novartis Ag | Organic compounds |
| US6887896B1 (en) * | 2003-10-29 | 2005-05-03 | Allergan, Inc. | 7-[(7-Alkoxy)-chrom-3-en-6-yl]-heptatrienoic acid and 7-[(3-alkoxy)-5,6-dihydronaphthalen-2-yl]-heptatrienoic acid derivatives having serum glucose reducing activity |
| EP2428516A1 (en) | 2003-11-19 | 2012-03-14 | Metabasis Therapeutics, Inc. | Novel phosphorus-containing thyromimetics |
| US20090232879A1 (en) | 2005-05-26 | 2009-09-17 | Metabasis Therapeutics, Inc. | Thyromimetics for the Treatment of Fatty Liver Diseases |
| JP5149388B2 (ja) | 2007-09-12 | 2013-02-20 | ザ トラスティーズ オブ コロンビア ユニバーシティ イン ザ シティ オブ ニューヨーク | 黄斑変性症を処置するための組成物及び方法 |
| JP6723752B2 (ja) * | 2015-02-10 | 2020-07-15 | 公益財団法人相模中央化学研究所 | 二次電池用電解液 |
| WO2018094265A2 (en) | 2016-11-21 | 2018-05-24 | Viking Therapeutics, Inc. | Method of treating glycogen storage disease |
| AU2018280118B2 (en) | 2017-06-05 | 2021-07-15 | Viking Therapeutics, Inc. | Compositions for the treatment of fibrosis |
| EA202091979A1 (ru) | 2018-03-22 | 2021-06-22 | Вайкинг Терапьютикс, Инк. | Кристаллические формы и способы получения кристаллических форм соединения |
| EP4775207A2 (en) | 2018-12-05 | 2026-07-15 | Viking Therapeutics, Inc. | Compositions for the treatment of fibrosis |
| EP4161925A4 (en) | 2020-06-09 | 2024-09-04 | Viking Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIVER DISEASES |
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| US5071773A (en) * | 1986-10-24 | 1991-12-10 | The Salk Institute For Biological Studies | Hormone receptor-related bioassays |
| US4981784A (en) * | 1987-12-02 | 1991-01-01 | The Salk Institute For Biological Studies | Retinoic acid receptor method |
| US5977125A (en) * | 1994-10-31 | 1999-11-02 | Eisai Co., Ltd. | Mono-or polyenic carboxylic acid derivatives |
| EP0788353A1 (en) * | 1995-09-18 | 1997-08-13 | Ligand Pharmaceuticals, Inc. | Ppar gamma antagonists for treating obesity |
| AU726450B2 (en) * | 1995-10-06 | 2000-11-09 | Ligand Pharmaceuticals Incorporated | Dimer-selective RXR modulators and methods for their use |
| WO2000026172A1 (en) * | 1998-11-03 | 2000-05-11 | Ligand Pharmaceuticals Incorporated | Trienoic retinoid compounds as retinoic acid receptor antagonists |
| CN1337931A (zh) * | 1999-03-08 | 2002-02-27 | 巴斯利尔药物股份公司 | 类维生素a拮抗剂及其用途 |
| US6593493B1 (en) * | 1999-09-14 | 2003-07-15 | Ligand Pharmaceuticals, Inc. | RXR modulators with improved pharmacologic profile |
| CA2452541A1 (en) * | 2001-07-20 | 2003-01-30 | Eli Lilly And Company | (pyridinyl and pyrimidyl) trienoic acid derivatives as retinoid x receptor modulators |
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2002
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- 2002-03-12 WO PCT/US2002/007718 patent/WO2002072528A1/en not_active Ceased
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- 2002-03-12 JP JP2002571445A patent/JP2004526725A/ja active Pending
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- 2002-03-12 MX MXPA03008229A patent/MXPA03008229A/es active IP Right Grant
- 2002-03-12 CA CA002438874A patent/CA2438874A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002255732B2 (en) | 2006-03-09 |
| EP1368296A1 (en) | 2003-12-10 |
| US20040248919A1 (en) | 2004-12-09 |
| JP2004526725A (ja) | 2004-09-02 |
| WO2002072528A1 (en) | 2002-09-19 |
| MXPA03008229A (es) | 2004-11-12 |
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