CA2429059A1 - Coated medical devices for the prevention and treatment of vascular disease - Google Patents
Coated medical devices for the prevention and treatment of vascular disease Download PDFInfo
- Publication number
- CA2429059A1 CA2429059A1 CA 2429059 CA2429059A CA2429059A1 CA 2429059 A1 CA2429059 A1 CA 2429059A1 CA 2429059 CA2429059 CA 2429059 CA 2429059 A CA2429059 A CA 2429059A CA 2429059 A1 CA2429059 A1 CA 2429059A1
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- CA
- Canada
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- compounds
- medical device
- intraluminal medical
- prevention
- concentration
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Abstract
A drug and drug delivery system may be utilized in the treatment of vascular disease. A local delivery system is coated with rapamycin or other suitable drug, agent or compound and delivered intraluminally for the treatment and prevention of neointimal hyperplasia following percutaneous transluminal coronary angiography. The local delivery of the drugs or agents provides for increased effectiveness and lower systemic toxicity.
Claims (21)
1. A method for the prevention of target lesion restenosis comprising the controlled delivery, by a profiled release from an intraluminal medical device, of one or more compounds in therapeutic dosage amounts.
2. The method for the prevention of target lesion restenosis according to Claim 1, wherein the profiled release from an intraluminal medical device of one or more compounds comprises:
coating a first portion of the stent with a first concentration of the one or more compounds in therapeutic dosage amounts; and coating a second portion of the stent with a second concentration of the one or more compounds in therapeutic dosage amounts, wherein the second concentration is greater than the first concentration.
coating a first portion of the stent with a first concentration of the one or more compounds in therapeutic dosage amounts; and coating a second portion of the stent with a second concentration of the one or more compounds in therapeutic dosage amounts, wherein the second concentration is greater than the first concentration.
3. The method for the prevention of target lesion restenosis according to Claim 2, wherein the one or more compounds comprises rapamycin.
4. The method for the prevention of target lesion restenosis according to Claim 1, wherein the one or more compounds comprises rapamycin.
5. The method for the prevention of target lesion restenosis according to Claim 1, wherein the one or more compounds comprises analogs, derivatives and congeners that bind a high-affinity cytosolic protein, FKBP12, and possesses the same pharmacologic properties as rapamycin.
6. The method for the prevention of target lesion restenosis according to Claim 1, wherein the profiled release from an intraluminal medical device of one or more compounds comprises:
coating a first portion of the stent with a first concentration of the one or more compounds in therapeutic dosage amounts; and coating a second portion of the stent with a second concentration of another of the one or more compounds in therapeutic dosage amounts.
coating a first portion of the stent with a first concentration of the one or more compounds in therapeutic dosage amounts; and coating a second portion of the stent with a second concentration of another of the one or more compounds in therapeutic dosage amounts.
7. The method for the prevention of target lesion restenosis according to Claim 6, wherein the one or more compounds comprises rapamycin.
8. The method for the prevention of target lesion restenosis according to Claim 7, wherein the another of the one or more compounds comprises a high solubility inhibitor of the mammalin Target of Rapamycin.
9. The method for the prevention of target lesion restenosis according to Claim 1, further comprising adding an agent to enhance tissue penetration of the one or more compounds.
10. The method for the prevention of target lesion restenosis according to Claim 1, wherein the profiled release from an intraluminal medical device of one or more compounds comprises:
coating a first portion of the stent with a first mass of the one or more compounds in therapeutic dosage amounts in combination with a polymer; and coating a second portion of the stent with a second mass of the one or more compounds in therapeutic dosage amounts in combination with a polymer, wherein the second mass is greater than the first mass.
coating a first portion of the stent with a first mass of the one or more compounds in therapeutic dosage amounts in combination with a polymer; and coating a second portion of the stent with a second mass of the one or more compounds in therapeutic dosage amounts in combination with a polymer, wherein the second mass is greater than the first mass.
11. A drug delivery device comprising:
an intraluminal medical device; and a therapeutic dosage of one or more compounds releasably affixed, in a predetermined profile, to the intraluminal medical device for the treatment of target lesion restenosis.
an intraluminal medical device; and a therapeutic dosage of one or more compounds releasably affixed, in a predetermined profile, to the intraluminal medical device for the treatment of target lesion restenosis.
12. Drug delivery device according to Claim 11, wherein the intraluminal medical device comprises a stent.
13. The drug delivery device according to Claim 11, wherein the one or more compounds comprises rapamycin.
14. The drug delivery device according to Claim 11, wherein the one or more compounds comprises analogs, derivatives and congeners that bind a high-affinity cytosolic protein, FKBP12, and possesses the same pharmacologic properties as rapamycin.
15. The drug delivery device according to Claim 11, wherein the therapeutic dosage of one or more compounds releasably affixed, in a predetermined profile, to the intraluminal medical device comprises:
a first concentration of the one or more compounds affixed to a first portion of the intraluminal medical device; and a second concentration of the one or more compounds affixed to a second portion of the intraluminal medical device, wherein the second concentration is greater than the first concentration.
a first concentration of the one or more compounds affixed to a first portion of the intraluminal medical device; and a second concentration of the one or more compounds affixed to a second portion of the intraluminal medical device, wherein the second concentration is greater than the first concentration.
16. The drug delivery device according to Claim 15, wherein the one or more compounds comprises rapamycin.
17. The drug delivery device according to Claim 11, wherein the therapeutic dosage of one or more compounds releasably affixed, in a predetermined profile, to the intraluminal medical device comprises:
a first concentration of the one or more compounds affixed to a first portion of the intraluminal medical device; and a second concentration of another of one or more compounds affixed to a second portion of the intraluminal medical device.
a first concentration of the one or more compounds affixed to a first portion of the intraluminal medical device; and a second concentration of another of one or more compounds affixed to a second portion of the intraluminal medical device.
18. The drug delivery device according to Claim 17, wherein the one or more compounds comprises rapamycin.
19. The drug delivery device according to Claim 17, wherein the another of the one or more compounds comprises a high solubility inhibitor of the mammalian Target of Rapamycin.
20. The drug delivery device according to Claim 11, further comprising an agent for enhancing tissue penetration of the one or more compounds incorporated into the therapeutic dosage of one or more compounds releasably affixed in a predetermined profile to the intraluminal medical device.
21. The drug delivery device according to Claim 11, wherein the therapeutic dosage of one or more compounds releasably affixed, in a predetermined profile, to the intraluminal medical device comprises:
a first mass of the one or more compounds in combination with a polymer affixed to a first portion of the intraluminal medical device; and a second mass of the one or more compounds in combination with a polymer affixed to a second portion of the intraluminal medical device, the second mass is greater than the first mass.
a first mass of the one or more compounds in combination with a polymer affixed to a first portion of the intraluminal medical device; and a second mass of the one or more compounds in combination with a polymer affixed to a second portion of the intraluminal medical device, the second mass is greater than the first mass.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38198602P | 2002-05-20 | 2002-05-20 | |
| US60/381,986 | 2002-05-20 | ||
| US10/431,059 US7419678B2 (en) | 2000-05-12 | 2003-05-07 | Coated medical devices for the prevention and treatment of vascular disease |
| US10/431,059 | 2003-05-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2429059A1 true CA2429059A1 (en) | 2003-11-20 |
| CA2429059C CA2429059C (en) | 2011-10-25 |
Family
ID=29584344
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2429059A Expired - Lifetime CA2429059C (en) | 2002-05-20 | 2003-05-20 | Coated medical devices for the prevention and treatment of vascular disease |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2429059C (en) |
-
2003
- 2003-05-20 CA CA2429059A patent/CA2429059C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2429059C (en) | 2011-10-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20230523 |