CA2429007A1 - Sample introduction device for mass spectrometry using a fast fluidic system to synchronize multiple parallel liquid sample streams - Google Patents
Sample introduction device for mass spectrometry using a fast fluidic system to synchronize multiple parallel liquid sample streams Download PDFInfo
- Publication number
- CA2429007A1 CA2429007A1 CA002429007A CA2429007A CA2429007A1 CA 2429007 A1 CA2429007 A1 CA 2429007A1 CA 002429007 A CA002429007 A CA 002429007A CA 2429007 A CA2429007 A CA 2429007A CA 2429007 A1 CA2429007 A1 CA 2429007A1
- Authority
- CA
- Canada
- Prior art keywords
- fluid sample
- introduction device
- sample stream
- mass spectrometry
- multiple parallel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000007788 liquid Substances 0.000 title 1
- 238000004949 mass spectrometry Methods 0.000 title 1
- 239000012530 fluid Substances 0.000 abstract 6
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Electron Tubes For Measurement (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Abstract
ABSTRACT A sample introduction device for introducing a plurality of independent fluid sample streams into a mass spectrometer includes a manifold (84) having a plurality of fluid sample stream direct paths. Each direct path extends between a fluid sample stream inlet (80, 82) and a fluid sample stream outlet. A plurality of bypass paths (92, 96) is also provided in the manifold.
Each bypass path is coupled to a respective one of the direct paths between the inlet and outlet. A plurality of transfer lines (86,94) is also provided with each transfer line being coupled to a respective one of the outlets to deliver a fluid sample stream to an ionization region of the mass spectrometer. A valve (90, 96) is positioned in each of the bypass paths and is actuable to divert the fluid sample stream entering the direct path via the inlet from the direct path and into the bypass path.
Each bypass path is coupled to a respective one of the direct paths between the inlet and outlet. A plurality of transfer lines (86,94) is also provided with each transfer line being coupled to a respective one of the outlets to deliver a fluid sample stream to an ionization region of the mass spectrometer. A valve (90, 96) is positioned in each of the bypass paths and is actuable to divert the fluid sample stream entering the direct path via the inlet from the direct path and into the bypass path.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25361600P | 2000-11-28 | 2000-11-28 | |
| US60/253,616 | 2000-11-28 | ||
| US27006701P | 2001-02-20 | 2001-02-20 | |
| US60/270,067 | 2001-02-20 | ||
| PCT/CA2001/001673 WO2002044684A2 (en) | 2000-11-28 | 2001-11-28 | Sample introduction device for mass spectrometry using a fast fluidic system to synchronize multiple parallel liquid sample streams |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2429007A1 true CA2429007A1 (en) | 2002-06-06 |
| CA2429007C CA2429007C (en) | 2008-11-25 |
Family
ID=26943414
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002429007A Expired - Fee Related CA2429007C (en) | 2000-11-28 | 2001-11-28 | Sample introduction device for mass spectrometry using a fast fluidic system to synchronize multiple parallel liquid sample streams |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1338026B1 (en) |
| JP (1) | JP3917938B2 (en) |
| AT (1) | ATE502391T1 (en) |
| AU (2) | AU2334302A (en) |
| CA (1) | CA2429007C (en) |
| DE (1) | DE60144243D1 (en) |
| WO (1) | WO2002044684A2 (en) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7132650B1 (en) | 2003-09-26 | 2006-11-07 | Nanostream, Inc. | High throughput multi-dimensional sample analysis |
| US7214320B1 (en) | 2002-08-08 | 2007-05-08 | Nanostream, Inc. | Systems and methods for high throughput sample analysis |
| US6812458B2 (en) | 2002-08-08 | 2004-11-02 | Nanostream, Inc. | Systems and methods for high-throughput microfluidic sample analysis |
| US6987263B2 (en) * | 2002-12-13 | 2006-01-17 | Nanostream, Inc. | High throughput systems and methods for parallel sample analysis |
| EP2285462B1 (en) * | 2008-05-27 | 2020-12-16 | PerkinElmer Health Sciences, Inc. | Method and device for modulating flow of a fluid in a chromatography system |
| AU2010228936B2 (en) | 2009-03-24 | 2015-07-09 | Perkinelmer U.S. Llc | Sorbent devices with longitudinal diffusion paths and methods of using them |
| US8388736B2 (en) | 2009-10-02 | 2013-03-05 | Perkinelmer Health Sciences, Inc. | Sorbent devices and methods of using them |
| EP2580585B1 (en) | 2010-06-14 | 2019-09-18 | PerkinElmer Health Sciences, Inc. | Fluidic devices and methods of using them |
| CA2812269C (en) | 2010-09-22 | 2019-04-09 | Perkinelmer Health Sciences, Inc. | Backflush methods and devices for chromatography |
| US9241779B2 (en) | 2012-11-02 | 2016-01-26 | Coloplast A/S | Male incontinence treatment system |
| US10111651B2 (en) | 2012-11-02 | 2018-10-30 | Coloplast A/S | System and method of anchoring support material to tissue |
| US9480546B2 (en) | 2013-08-05 | 2016-11-01 | Coloplast A/S | Hysteropexy mesh apparatuses and methods |
| US9522000B2 (en) | 2013-11-08 | 2016-12-20 | Coloplast A/S | System and a method for surgical suture fixation |
| JP6362161B2 (en) * | 2014-05-27 | 2018-07-25 | 国立大学法人 名古屋工業大学 | Mass spectrometer |
| WO2017004010A1 (en) | 2015-06-30 | 2017-01-05 | Perkinelmer Health Sciences, Inc. | Chromatography systems with mobile phase generators |
| WO2017046849A1 (en) * | 2015-09-14 | 2017-03-23 | 株式会社日立ハイテクノロジーズ | Mass spectrometer |
| GB2572671B (en) | 2019-02-01 | 2021-09-22 | Agilent Technologies Inc | Interface device between sample separation device and mass spectrometer having multiple sample capillaries |
| US20220250102A1 (en) * | 2019-07-31 | 2022-08-11 | National Institute Of Advanced Industrial Science And Technology | Spray ionization device, analysis device, and surface coating device |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0169469A3 (en) * | 1984-07-27 | 1987-10-14 | BASF Corporation | Analytical apparatus |
| US5872010A (en) * | 1995-07-21 | 1999-02-16 | Northeastern University | Microscale fluid handling system |
| US6054047A (en) * | 1998-03-27 | 2000-04-25 | Synsorb Biotech, Inc. | Apparatus for screening compound libraries |
| US6066848A (en) * | 1998-06-09 | 2000-05-23 | Combichem, Inc. | Parallel fluid electrospray mass spectrometer |
-
2001
- 2001-11-28 AU AU2334302A patent/AU2334302A/en active Pending
- 2001-11-28 CA CA002429007A patent/CA2429007C/en not_active Expired - Fee Related
- 2001-11-28 WO PCT/CA2001/001673 patent/WO2002044684A2/en active Application Filing
- 2001-11-28 AU AU2002223343A patent/AU2002223343B2/en not_active Ceased
- 2001-11-28 EP EP01998807A patent/EP1338026B1/en not_active Expired - Lifetime
- 2001-11-28 JP JP2002546183A patent/JP3917938B2/en not_active Expired - Fee Related
- 2001-11-28 DE DE60144243T patent/DE60144243D1/en not_active Expired - Lifetime
- 2001-11-28 AT AT01998807T patent/ATE502391T1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002044684A3 (en) | 2003-02-27 |
| EP1338026A2 (en) | 2003-08-27 |
| JP2004525483A (en) | 2004-08-19 |
| AU2334302A (en) | 2002-06-11 |
| DE60144243D1 (en) | 2011-04-28 |
| AU2002223343B2 (en) | 2007-01-18 |
| JP3917938B2 (en) | 2007-05-23 |
| WO2002044684A2 (en) | 2002-06-06 |
| ATE502391T1 (en) | 2011-04-15 |
| EP1338026B1 (en) | 2011-03-16 |
| CA2429007C (en) | 2008-11-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20171128 |