CA2416606A1 - Apparatus and method for reduction of bias in amperometric sensors - Google Patents
Apparatus and method for reduction of bias in amperometric sensors Download PDFInfo
- Publication number
- CA2416606A1 CA2416606A1 CA002416606A CA2416606A CA2416606A1 CA 2416606 A1 CA2416606 A1 CA 2416606A1 CA 002416606 A CA002416606 A CA 002416606A CA 2416606 A CA2416606 A CA 2416606A CA 2416606 A1 CA2416606 A1 CA 2416606A1
- Authority
- CA
- Canada
- Prior art keywords
- analyte
- potential
- test sample
- concentration
- fluid test
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Apparatus and method are provided for determining the concentration of an analyte in a fluid test sample by applying the fluid test sample to the surface of a work- ing electrode which is electrochemically connected to a reference electrode which surface bears a composition comprising an enzyme specific for the analyte. A media- tor is reduced in response to a reaction between the ana- lyte and the enzyme. An oxidizing potential is applied between the electrodes to return at least a portion of the mediator back to its oxidized form before determining the concentration of the analyte to thereby increase the accuracy of the analyte determination. Following this initially applied potential, the circuit is switched to an open circuit or to a potential that substantially re- duces the current to minimize the rate of electrochemical potential at the working electrode. A second potential is applied between the electrodes and the current gener- ated in the fluid test sample is measured to determine analyte concentration. Optionally, the accuracy of the analyte determination is further enhanced algorithmi- cally.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/435,993 US5620579A (en) | 1995-05-05 | 1995-05-05 | Apparatus for reduction of bias in amperometric sensors |
US08/435,993 | 1995-05-05 | ||
CA002170660A CA2170660C (en) | 1995-05-05 | 1996-02-29 | Method and apparatus for reduction of bias in amperometric sensors |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002170660A Division CA2170660C (en) | 1995-05-05 | 1996-02-29 | Method and apparatus for reduction of bias in amperometric sensors |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2416606A1 true CA2416606A1 (en) | 1996-11-06 |
CA2416606C CA2416606C (en) | 2007-01-09 |
Family
ID=25678358
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002416606A Expired - Lifetime CA2416606C (en) | 1995-05-05 | 1996-02-29 | Apparatus and method for reduction of bias in amperometric sensors |
Country Status (1)
Country | Link |
---|---|
CA (1) | CA2416606C (en) |
-
1996
- 1996-02-29 CA CA002416606A patent/CA2416606C/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CA2416606C (en) | 2007-01-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |
Effective date: 20160229 |
|
MKEX | Expiry |
Effective date: 20160229 |