CA2416606A1 - Apparatus and method for reduction of bias in amperometric sensors - Google Patents

Apparatus and method for reduction of bias in amperometric sensors Download PDF

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Publication number
CA2416606A1
CA2416606A1 CA002416606A CA2416606A CA2416606A1 CA 2416606 A1 CA2416606 A1 CA 2416606A1 CA 002416606 A CA002416606 A CA 002416606A CA 2416606 A CA2416606 A CA 2416606A CA 2416606 A1 CA2416606 A1 CA 2416606A1
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CA
Canada
Prior art keywords
analyte
potential
test sample
concentration
fluid test
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002416606A
Other languages
French (fr)
Other versions
CA2416606C (en
Inventor
Marvin A. Genshaw
Dijia Huang
Matthew K. Musho
Kin-Fai Yip
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ascensia Diabetes Care Holdings AG
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Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/435,993 external-priority patent/US5620579A/en
Application filed by Individual filed Critical Individual
Publication of CA2416606A1 publication Critical patent/CA2416606A1/en
Application granted granted Critical
Publication of CA2416606C publication Critical patent/CA2416606C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Apparatus and method are provided for determining the concentration of an analyte in a fluid test sample by applying the fluid test sample to the surface of a work- ing electrode which is electrochemically connected to a reference electrode which surface bears a composition comprising an enzyme specific for the analyte. A media- tor is reduced in response to a reaction between the ana- lyte and the enzyme. An oxidizing potential is applied between the electrodes to return at least a portion of the mediator back to its oxidized form before determining the concentration of the analyte to thereby increase the accuracy of the analyte determination. Following this initially applied potential, the circuit is switched to an open circuit or to a potential that substantially re- duces the current to minimize the rate of electrochemical potential at the working electrode. A second potential is applied between the electrodes and the current gener- ated in the fluid test sample is measured to determine analyte concentration. Optionally, the accuracy of the analyte determination is further enhanced algorithmi- cally.
CA002416606A 1995-05-05 1996-02-29 Apparatus and method for reduction of bias in amperometric sensors Expired - Lifetime CA2416606C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/435,993 US5620579A (en) 1995-05-05 1995-05-05 Apparatus for reduction of bias in amperometric sensors
US08/435,993 1995-05-05
CA002170660A CA2170660C (en) 1995-05-05 1996-02-29 Method and apparatus for reduction of bias in amperometric sensors

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA002170660A Division CA2170660C (en) 1995-05-05 1996-02-29 Method and apparatus for reduction of bias in amperometric sensors

Publications (2)

Publication Number Publication Date
CA2416606A1 true CA2416606A1 (en) 1996-11-06
CA2416606C CA2416606C (en) 2007-01-09

Family

ID=25678358

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002416606A Expired - Lifetime CA2416606C (en) 1995-05-05 1996-02-29 Apparatus and method for reduction of bias in amperometric sensors

Country Status (1)

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CA (1) CA2416606C (en)

Also Published As

Publication number Publication date
CA2416606C (en) 2007-01-09

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