CA2413883C - Procede de prevention de dommages tissulaires associes a une reaction du greffon contre l'hote ou une reaction de l'hote contre le greffon qui suit une transplantation - Google Patents

Procede de prevention de dommages tissulaires associes a une reaction du greffon contre l'hote ou une reaction de l'hote contre le greffon qui suit une transplantation Download PDF

Info

Publication number
CA2413883C
CA2413883C CA002413883A CA2413883A CA2413883C CA 2413883 C CA2413883 C CA 2413883C CA 002413883 A CA002413883 A CA 002413883A CA 2413883 A CA2413883 A CA 2413883A CA 2413883 C CA2413883 C CA 2413883C
Authority
CA
Canada
Prior art keywords
topically active
active corticosteroid
versus
patient
graft
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002413883A
Other languages
English (en)
Other versions
CA2413883A1 (fr
Inventor
George B. Mcdonald
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Enteron Pharmaceuticals Inc
Original Assignee
Enteron Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enteron Pharmaceuticals Inc filed Critical Enteron Pharmaceuticals Inc
Publication of CA2413883A1 publication Critical patent/CA2413883A1/fr
Application granted granted Critical
Publication of CA2413883C publication Critical patent/CA2413883C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

La présente invention concerne un procédé de prévention de dommages tissulaires associés à une réaction du greffon contre l'hôte chez un patient ayant subi une transplantation de cellules hématopoïétiques et associés à une réaction de l'hôte contre le greffon chez un patient ayant subi une allogreffe d'organe. Ce procédé consiste à administrer à un patient, par voie orale, une quantité à efficacité prophylactique d'un corticostéroïde à action topique, tel que le dipropionate de béclométhasone, pendant une certaine période suivant la transplantation de cellules hématopoïétiques ou l'allogreffe d'organe, et avant l'apparition de symptômes associés à une réaction du greffon contre l'hôte ou à une réaction de l'hôte contre le greffon. Des tissus représentatifs de l'invention comprennent le tissu de l'intestin et du foie et des dommages tissulaires représentatifs de l'invention comprennent l'inflammation desdits tissus.
CA002413883A 2000-05-22 2000-05-22 Procede de prevention de dommages tissulaires associes a une reaction du greffon contre l'hote ou une reaction de l'hote contre le greffon qui suit une transplantation Expired - Lifetime CA2413883C (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2000/014064 WO2001089529A1 (fr) 2000-05-22 2000-05-22 Procede de prevention de dommages tissulaires associes a une reaction du greffon contre l'hote ou une reaction de l'hote contre le greffon qui suit une transplantation

Publications (2)

Publication Number Publication Date
CA2413883A1 CA2413883A1 (fr) 2001-11-29
CA2413883C true CA2413883C (fr) 2009-07-28

Family

ID=21741408

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002413883A Expired - Lifetime CA2413883C (fr) 2000-05-22 2000-05-22 Procede de prevention de dommages tissulaires associes a une reaction du greffon contre l'hote ou une reaction de l'hote contre le greffon qui suit une transplantation

Country Status (3)

Country Link
AU (1) AU2000250389A1 (fr)
CA (1) CA2413883C (fr)
WO (1) WO2001089529A1 (fr)

Also Published As

Publication number Publication date
CA2413883A1 (fr) 2001-11-29
WO2001089529A1 (fr) 2001-11-29
AU2000250389A1 (en) 2001-12-03

Similar Documents

Publication Publication Date Title
McDonald et al. Oral beclomethasone dipropionate for treatment of intestinal graft-versus-host disease: a randomized, controlled trial
US6096731A (en) Method for preventing tissue damage associated with graft-versus-host or host-versus-graft disease following transplantation
Rastegarpanah et al. A randomized, double blinded, placebo-controlled clinical trial of silymarin in ulcerative colitis
Powell-Jackson et al. ADULT RESPIRATORY DISTRESS SYNDROME AND CONVULSIONS ASSOCIATED WITH AMINISTRATION OF CYCLOSPORINE IN LIVER TRANSPLANT RECIPIENTS
Carpenter et al. Management of acute graft-versus-host disease in children
Barry Immunosuppressive drugs in renal transplantation: a review of the regimens
Fleckenstein et al. A prospective, randomized, double-blind trial evaluating the efficacy of ursodeoxycholic acid in prevention of liver transplant rejection
US20100184732A1 (en) Method of long-term treatment of graft-versus-host disease using topical active corticosteroids
Baehr et al. Oral beclomethasone dipropionate for treatment of human intestinal graft-versus-host disease
CA2413883C (fr) Procede de prevention de dommages tissulaires associes a une reaction du greffon contre l'hote ou une reaction de l'hote contre le greffon qui suit une transplantation
AU2005321826B2 (en) Treatment of graft-versus-host disease and leukemia with beclomethasone dipropionate and prednisone
US6239120B1 (en) Method and means for treating glomerulonephritis
US20020086857A1 (en) Method of long-term treatment of graft-versus-host disease using topical active corticosterioids
Stotland et al. Newer treatments for inflammatory bowel disease
EP1056461B1 (fr) Des glucocorticoides pour le traitement de la glomerulonephrite
US20030032631A1 (en) Method of treatment of cancer by controlling graft-versus-leukemia using topical active corticosteriods
Drabble et al. Acute gastrocnemius myositis
Sohi et al. Management of refractory ulcerative colitis
Wong et al. Fulminant ulcerative colitis
Moses et al. Inflammatory bowel disease: 1. Origins, presentation, and course
Edelman et al. Suppressor T cells with histamine type II receptors in chickens bearing chemically induced fibrosarcomas
Katz Update in medical therapy in inflammatory bowel disease: a clinician’s view
US20140328929A1 (en) Method of Preventing Acute Graft-Versus-Host Disease using Oral Beclomethasone Dipropionate
WO2023150512A1 (fr) Nouveau régime pour augmenter et étendre la tolérance aux greffes
Jamieson Corticosteroids for rheumatic disease: 1. Physiology, pharmacology, and therapeutic strategies

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20200522