CA2410981A1 - Particules d'adenovirus avec proteines de fibres mutagenisees - Google Patents
Particules d'adenovirus avec proteines de fibres mutagenisees Download PDFInfo
- Publication number
- CA2410981A1 CA2410981A1 CA002410981A CA2410981A CA2410981A1 CA 2410981 A1 CA2410981 A1 CA 2410981A1 CA 002410981 A CA002410981 A CA 002410981A CA 2410981 A CA2410981 A CA 2410981A CA 2410981 A1 CA2410981 A1 CA 2410981A1
- Authority
- CA
- Canada
- Prior art keywords
- leu
- thr
- ser
- gly
- asn
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10211—Aviadenovirus, e.g. fowl adenovirus A
- C12N2710/10222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10211—Aviadenovirus, e.g. fowl adenovirus A
- C12N2710/10241—Use of virus, viral particle or viral elements as a vector
- C12N2710/10243—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/40—Vectors comprising a peptide as targeting moiety, e.g. a synthetic peptide, from undefined source
- C12N2810/405—Vectors comprising RGD peptide
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
- C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
- C12N2810/6009—Vectors comprising as targeting moiety peptide derived from defined protein from viruses dsDNA viruses
- C12N2810/6018—Adenoviridae
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Cette invention se rapporte à des protéines de fibres adénovirales mutées et à des particules d'adénovirus contenant ces protéines, à des polynucléotides codant ces protéines et à des vecteurs contenant ces polynucléotides, ainsi qu'à des procédés de production et d'utilisation de ces particules adénovirales. Grâce à ces protéines de fibres mutées, les particules d'adénovirus ne se fixent plus à leur récepteur cellulaire naturel. Elles peuvent être alors reciblées sur un type de cellule spécifique grâce à l'addition d'un ligand au capside du virus, qui amène le virus à se fixer à une telle cellule et à l'infecter. On a établi la liste des mutations de fibres spécifiques qui suppriment la fixation au récepteur naturel. On a découvert que des particules d'adénovirus ayant certaines mutations de fibres augmentent le transfert génique et l'expression dans le foie par rapport à des particules virales ayant une fibre de type sauvage.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58534400A | 2000-06-02 | 2000-06-02 | |
US09/585,344 | 2000-06-02 | ||
US27055501P | 2001-02-22 | 2001-02-22 | |
US60/270,555 | 2001-02-22 | ||
PCT/EP2001/006286 WO2001092299A2 (fr) | 2000-06-02 | 2001-06-01 | Particules d'adenovirus avec proteines de fibres mutagenisees |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2410981A1 true CA2410981A1 (fr) | 2001-12-06 |
Family
ID=26954360
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002410981A Abandoned CA2410981A1 (fr) | 2000-06-02 | 2001-06-01 | Particules d'adenovirus avec proteines de fibres mutagenisees |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1364038A2 (fr) |
JP (1) | JP2004512015A (fr) |
AU (1) | AU2001283832A1 (fr) |
CA (1) | CA2410981A1 (fr) |
IL (1) | IL153143A0 (fr) |
WO (1) | WO2001092299A2 (fr) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7232899B2 (en) | 1996-09-25 | 2007-06-19 | The Scripps Research Institute | Adenovirus vectors, packaging cell lines, compositions, and methods for preparation and use |
JP2007503843A (ja) | 2003-05-14 | 2007-03-01 | イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー | アデノウイルス親和性の拡大 |
FR2856928A1 (fr) * | 2003-07-04 | 2005-01-07 | Inst Nat Sante Rech Med | Nouveau compose adjuvant de l'immunite, compositions le contenant et procedes mettant en oeuvre ledit compose adjuvant |
JP4478775B2 (ja) | 2003-07-31 | 2010-06-09 | 財団法人名古屋産業科学研究所 | 増殖制御型組換えアデノウイルスベクターの効率的な作製方法及びその作製用キット |
US7473418B2 (en) | 2004-03-25 | 2009-01-06 | Cell Genesys, Inc. | Pan cancer oncolytic vectors and methods of use thereof |
CN113954923B (zh) * | 2021-11-02 | 2024-04-26 | 交控科技股份有限公司 | 一种编组列车停车控制方法和控制系统 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5846782A (en) * | 1995-11-28 | 1998-12-08 | Genvec, Inc. | Targeting adenovirus with use of constrained peptide motifs |
FR2761689B1 (fr) * | 1997-04-02 | 1999-06-25 | Transgene Sa | Fibre adenovirale modifiee et adenovirus cibles |
AU743051B2 (en) * | 1997-05-08 | 2002-01-17 | Genetic Therapy, Inc. | Gene transfer with adenoviruses having modified fiber proteins |
AU767975B2 (en) * | 1998-09-11 | 2003-11-27 | Genvec, Inc. | Alternatively targeted adenovirus |
-
2001
- 2001-06-01 EP EP01962700A patent/EP1364038A2/fr not_active Withdrawn
- 2001-06-01 AU AU2001283832A patent/AU2001283832A1/en not_active Abandoned
- 2001-06-01 CA CA002410981A patent/CA2410981A1/fr not_active Abandoned
- 2001-06-01 WO PCT/EP2001/006286 patent/WO2001092299A2/fr not_active Application Discontinuation
- 2001-06-01 IL IL15314301A patent/IL153143A0/xx unknown
- 2001-06-01 JP JP2002500910A patent/JP2004512015A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2004512015A (ja) | 2004-04-22 |
WO2001092299A2 (fr) | 2001-12-06 |
WO2001092299A3 (fr) | 2003-09-04 |
AU2001283832A1 (en) | 2001-12-11 |
IL153143A0 (en) | 2003-06-24 |
WO2001092299A9 (fr) | 2002-09-19 |
EP1364038A2 (fr) | 2003-11-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |