CA2406999A1 - Gene et variation de sequence associes a la perception de composes d'hydrates de carbone et d'autres produits sucrants - Google Patents

Gene et variation de sequence associes a la perception de composes d'hydrates de carbone et d'autres produits sucrants Download PDF

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Publication number
CA2406999A1
CA2406999A1 CA002406999A CA2406999A CA2406999A1 CA 2406999 A1 CA2406999 A1 CA 2406999A1 CA 002406999 A CA002406999 A CA 002406999A CA 2406999 A CA2406999 A CA 2406999A CA 2406999 A1 CA2406999 A1 CA 2406999A1
Authority
CA
Canada
Prior art keywords
dna
mouse
polynucleotide
leu
polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002406999A
Other languages
English (en)
Inventor
Alexander A. Bachmanov
Gary K. Beauchamp
Aurobindo Chatterjee
Pieter J. De Jong
Shanru Li
Xia Li
Jeffrey D. Ohmen
Danielle R. Reed
David Ross
Michael Guy Tordoff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monell Chemical Senses Center
Warner Lambert Co LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2406999A1 publication Critical patent/CA2406999A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Cette invention se rapporte à la découverte d'un gène et à sa variation de séquence associés à la préférence pour les hydrates de carbone, pour d'autres composés sucrants ou pour l'alcool éthylique. Cette invention concerne également l'étude des voies métaboliques permettant d'identifier d'autres gènes, des récepteurs et des relations qui contribuent aux différences de perception des hydrates de carbone ou de l'alcool éthylique. Cette invention concerne également des variations de séquence somatique ou de lignée germinale et leur utilisation dans le diagnostic et le pronostic de la prédisposition aux diabètes, à d'autres troubles associés à l'obésité et à la consommation d'alcool éthylique. Cette invention concerne également des sondes ou des amorces spécifiques de la détection et de l'analyse d'une telle variation de séquence, un procédé de criblage de médicaments pour l'inhibition ou le rétablissement d'une fonction génique, par exemple dans les thérapies contre le diabète, contre l'obésité ou contre la consommation d'alcool. Cette invention concerne en outre d'autres thérapies contre le diabète, contre les troubles de l'obésité ou contre la consommation de l'alcool, telles que la thérapie génique, ou la thérapie de remplacement des protéines, notamment. Cette invention concerne finalement un procédé d'identification de produits sucrants ou d'alcools utilisant ce gène et ses variations.
CA002406999A 2000-04-28 2001-04-25 Gene et variation de sequence associes a la perception de composes d'hydrates de carbone et d'autres produits sucrants Abandoned CA2406999A1 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US20079400P 2000-04-28 2000-04-28
US60/200,794 2000-04-28
US22141900P 2000-07-28 2000-07-28
US60/221,419 2000-07-28
US24744300P 2000-11-10 2000-11-10
US60/247,443 2000-11-10
PCT/US2001/013387 WO2001083749A2 (fr) 2000-04-28 2001-04-25 Gene et variation de sequence associes a la perception de composes d'hydrates de carbone et d'autres produits sucrants

Publications (1)

Publication Number Publication Date
CA2406999A1 true CA2406999A1 (fr) 2001-11-08

Family

ID=27394202

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002406999A Abandoned CA2406999A1 (fr) 2000-04-28 2001-04-25 Gene et variation de sequence associes a la perception de composes d'hydrates de carbone et d'autres produits sucrants

Country Status (5)

Country Link
EP (1) EP1280899A2 (fr)
JP (1) JP2003531614A (fr)
AU (1) AU2001255681A1 (fr)
CA (1) CA2406999A1 (fr)
WO (1) WO2001083749A2 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7402400B2 (en) 2001-07-03 2008-07-22 Regents Of The University Of California Mammalian sweet taste receptors
TW201006846A (en) 2000-03-07 2010-02-16 Senomyx Inc T1R taste receptor and genes encidung same
EP1301595A2 (fr) * 2000-05-22 2003-04-16 Incyte Genomics, Inc. Recepteurs couples par proteine g
US20040039170A1 (en) * 2000-09-25 2004-02-26 Sophia Kossida Regulation of human g protein-coupled receptor
TW201022287A (en) 2001-01-03 2010-06-16 Senomyx Inc T1R taste receptors and genes encoding same
US7301009B2 (en) 2001-06-26 2007-11-27 Senomyx, Inc. Isolated (T1R1/T1R3) umami taste receptors that respond to umami taste stimuli
US6955887B2 (en) 2001-03-30 2005-10-18 Senomyx, Inc. Use of T1R hetero-oligomeric taste receptor to screen for compounds that modulate taste signaling
US20080244761A1 (en) 2001-03-07 2008-10-02 Senomyx, Inc. T1r hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds
US7368285B2 (en) 2001-03-07 2008-05-06 Senomyx, Inc. Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same
US7309577B2 (en) 2001-03-07 2007-12-18 Senomyx, Inc. Binding assays that use the T1R1/T1R3 (umami) taste receptor to identify compounds that elicit or modulate umami taste
US7763431B1 (en) 2001-03-07 2010-07-27 Senomyx, Inc. Binding assays that use the T1R2/T1R3 (sweet) taste receptor to identify compounds that elicit or modulate sweet taste
IL158488A0 (en) * 2001-04-20 2004-05-12 Sinai School Medicine Tir3 a novel taste receptor
US7803982B2 (en) 2001-04-20 2010-09-28 The Mount Sinai School Of Medicine Of New York University T1R3 transgenic animals, cells and related methods
DK2327985T3 (en) 2001-06-26 2016-09-05 Senomyx Inc H1 Oligomeric T1R Taste Receptors and Cell Lines Expressing the Receptors, and Their Use to Identify Taste Compounds
CA2452716C (fr) * 2001-07-03 2012-06-26 The Regents Of The University Of California Recepteurs de gout heterodimeriques de gout sucre et d'acide amine, chez les mammiferes
US20050106571A1 (en) 2003-10-02 2005-05-19 The Regents Of The University Of California Mammalian T1R3 sweet taste receptors
WO2006113422A2 (fr) 2005-04-13 2006-10-26 The Government Of The Usa As Represented By The Secretary Of The Dept. Of Health And Human Services Variantes humaines du recepteur du sucre et de l'umami
US9804157B1 (en) 2013-03-15 2017-10-31 Senomyx, Inc. Screening assays to identify compounds which modulate T1R associated taste modalities which eliminate false positives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001064882A2 (fr) * 2000-02-29 2001-09-07 Millennium Pharmaceuticals, Inc. Recepteurs couples a une proteine g, numerotees 1983, 52881, 2398, 45449, 50289, et 52872, et utilisations correspondantes
TW201006846A (en) * 2000-03-07 2010-02-16 Senomyx Inc T1R taste receptor and genes encidung same
EP1301595A2 (fr) * 2000-05-22 2003-04-16 Incyte Genomics, Inc. Recepteurs couples par proteine g

Also Published As

Publication number Publication date
AU2001255681A1 (en) 2001-11-12
EP1280899A2 (fr) 2003-02-05
WO2001083749A2 (fr) 2001-11-08
JP2003531614A (ja) 2003-10-28
WO2001083749A3 (fr) 2002-07-18

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EEER Examination request
FZDE Dead