CA2404563A1 - Recepteurs couples aux proteines g humaines isoles de la sous-famille des proto-oncogenes mas, molecules d'acide nucleique codant les proteines rcpg humaines et leur utilisations - Google Patents
Recepteurs couples aux proteines g humaines isoles de la sous-famille des proto-oncogenes mas, molecules d'acide nucleique codant les proteines rcpg humaines et leur utilisations Download PDFInfo
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- CA2404563A1 CA2404563A1 CA002404563A CA2404563A CA2404563A1 CA 2404563 A1 CA2404563 A1 CA 2404563A1 CA 002404563 A CA002404563 A CA 002404563A CA 2404563 A CA2404563 A CA 2404563A CA 2404563 A1 CA2404563 A1 CA 2404563A1
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- 238000003259 recombinant expression Methods 0.000 description 1
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
- 238000007363 ring formation reaction Methods 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 210000003079 salivary gland Anatomy 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000002864 sequence alignment Methods 0.000 description 1
- 231100000004 severe toxicity Toxicity 0.000 description 1
- 239000013605 shuttle vector Substances 0.000 description 1
- 230000007781 signaling event Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 238000002741 site-directed mutagenesis Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 206010041823 squamous cell carcinoma Diseases 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000012916 structural analysis Methods 0.000 description 1
- 230000004960 subcellular localization Effects 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000003161 three-hybrid assay Methods 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000005026 transcription initiation Effects 0.000 description 1
- 230000005030 transcription termination Effects 0.000 description 1
- 230000002463 transducing effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000017105 transposition Effects 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 108010080629 tryptophan-leucine Proteins 0.000 description 1
- 238000003160 two-hybrid assay Methods 0.000 description 1
- 238000010396 two-hybrid screening Methods 0.000 description 1
- 238000010798 ubiquitination Methods 0.000 description 1
- 230000034512 ubiquitination Effects 0.000 description 1
- HFTAFOQKODTIJY-UHFFFAOYSA-N umbelliferone Natural products Cc1cc2C=CC(=O)Oc2cc1OCC=CC(C)(C)O HFTAFOQKODTIJY-UHFFFAOYSA-N 0.000 description 1
- ORHBXUUXSCNDEV-UHFFFAOYSA-N umbelliferone Chemical compound C1=CC(=O)OC2=CC(O)=CC=C21 ORHBXUUXSCNDEV-UHFFFAOYSA-N 0.000 description 1
- 230000009452 underexpressoin Effects 0.000 description 1
- 230000003827 upregulation Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 108010073969 valyllysine Proteins 0.000 description 1
- 210000001177 vas deferen Anatomy 0.000 description 1
- 230000029812 viral genome replication Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
- 238000001086 yeast two-hybrid system Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
L'invention concerne des séquences d'acides aminés de peptides codés par des gènes dans le génome humain, les peptides de récepteurs couplés aux protéines G (RCPG) de la présente invention. Cette invention concerne de manière spécifique des molécules d'acide nucléique et de peptides isolées, des méthodes d'identification de paralogues et d'orthologues des peptides RCPG et des méthodes d'identification de modulateurs des peptides RCPG.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19231000P | 2000-03-27 | 2000-03-27 | |
US60/192,310 | 2000-03-27 | ||
US62981700A | 2000-07-31 | 2000-07-31 | |
US09/629,817 | 2000-07-31 | ||
PCT/US2001/009657 WO2001072840A2 (fr) | 2000-03-27 | 2001-03-27 | Recepteurs couples aux proteines g humaines isoles de la sous-famille des proto-oncogenes mas, molecules d'acide nucleique codant les proteines rcpg humaines et leur utilisations |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2404563A1 true CA2404563A1 (fr) | 2001-10-04 |
Family
ID=26887962
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002404563A Abandoned CA2404563A1 (fr) | 2000-03-27 | 2001-03-27 | Recepteurs couples aux proteines g humaines isoles de la sous-famille des proto-oncogenes mas, molecules d'acide nucleique codant les proteines rcpg humaines et leur utilisations |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1278840A2 (fr) |
JP (1) | JP2003530834A (fr) |
AU (1) | AU2001252968A1 (fr) |
CA (1) | CA2404563A1 (fr) |
WO (1) | WO2001072840A2 (fr) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1242454A2 (fr) * | 1999-12-28 | 2002-09-25 | PHARMACIA & UPJOHN COMPANY | Nouveaux recepteurs couples a une proteine g |
EP1835928A2 (fr) * | 2004-12-22 | 2007-09-26 | Rheoscience A/S | Cibles pharmaceutiques bases sur les recepteurs couples a la proteine a apparente a mas |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8822483D0 (en) * | 1988-09-24 | 1988-10-26 | Medical Res Council | Developments relating to mas oncogene |
US5508384A (en) * | 1992-09-10 | 1996-04-16 | New York University | Polypeptide derived from a popamine receptor, and compositions and methods thereof |
EP0871667A4 (fr) * | 1994-11-18 | 1999-05-12 | Human Genome Sciences Inc | Recepteur couple a la proteine g |
SE9704836D0 (sv) * | 1997-12-22 | 1997-12-22 | Astra Pharma Inc | Novel receptor |
EP1242454A2 (fr) * | 1999-12-28 | 2002-09-25 | PHARMACIA & UPJOHN COMPANY | Nouveaux recepteurs couples a une proteine g |
WO2001062797A2 (fr) * | 2000-02-23 | 2001-08-30 | Pharmacia & Upjohn Company | Nouveaux recepteurs couples a la proteine g |
-
2001
- 2001-03-27 EP EP01926435A patent/EP1278840A2/fr not_active Ceased
- 2001-03-27 JP JP2001571771A patent/JP2003530834A/ja active Pending
- 2001-03-27 WO PCT/US2001/009657 patent/WO2001072840A2/fr not_active Application Discontinuation
- 2001-03-27 CA CA002404563A patent/CA2404563A1/fr not_active Abandoned
- 2001-03-27 AU AU2001252968A patent/AU2001252968A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2001252968A1 (en) | 2001-10-08 |
EP1278840A2 (fr) | 2003-01-29 |
JP2003530834A (ja) | 2003-10-21 |
WO2001072840A3 (fr) | 2002-03-21 |
WO2001072840A2 (fr) | 2001-10-04 |
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