CA2404060A1 - Methodes de traitement de la neoplasie avec des adenovirus specifiques des cellules cibles associes a la chimiotherapie et a la radiotherapie - Google Patents
Methodes de traitement de la neoplasie avec des adenovirus specifiques des cellules cibles associes a la chimiotherapie et a la radiotherapie Download PDFInfo
- Publication number
- CA2404060A1 CA2404060A1 CA002404060A CA2404060A CA2404060A1 CA 2404060 A1 CA2404060 A1 CA 2404060A1 CA 002404060 A CA002404060 A CA 002404060A CA 2404060 A CA2404060 A CA 2404060A CA 2404060 A1 CA2404060 A1 CA 2404060A1
- Authority
- CA
- Canada
- Prior art keywords
- specific
- tre
- cell
- cells
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10345—Special targeting system for viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Cette invention concerne des méthodes de traitement de la néoplasie avec des vecteurs adénoviraux spécifiques des cellules cibles capables de réplication, associés à la chimiothérapie ou à la radiothérapie, ou leurs combinaisons. Les vecteurs adénoviraux sont spécifiques des cellules cibles pour le type particulier de néoplasie pour lequel le traitement est nécessaire, et la chimiothérapie et/ou la radiothérapie combinées fournissent un traitement synergique relativement aux thérapies adénovirales existantes ou aux chimiothérapies et radiothérapies classiques.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19201500P | 2000-03-24 | 2000-03-24 | |
US60/192,015 | 2000-03-24 | ||
PCT/US2001/009042 WO2001072341A2 (fr) | 2000-03-24 | 2001-03-21 | Methodes de traitement de la neoplasie avec des adenovirus specifiques des cellules cibles associes a la chimiotherapie et a la radiotherapie |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2404060A1 true CA2404060A1 (fr) | 2001-10-04 |
Family
ID=22707882
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002404060A Abandoned CA2404060A1 (fr) | 2000-03-24 | 2001-03-21 | Methodes de traitement de la neoplasie avec des adenovirus specifiques des cellules cibles associes a la chimiotherapie et a la radiotherapie |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1318839A2 (fr) |
JP (1) | JP2003532638A (fr) |
AU (2) | AU2001243704B2 (fr) |
CA (1) | CA2404060A1 (fr) |
WO (1) | WO2001072341A2 (fr) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU4764801A (en) * | 2000-03-24 | 2001-10-08 | Calydon Inc | Cell-specific adenovirus vectors comprising an internal ribosome entry site |
EP1377672A2 (fr) | 2001-02-23 | 2004-01-07 | Novartis AG | Constructions de vecteurs |
WO2004042025A2 (fr) | 2002-11-01 | 2004-05-21 | Cell Genesys, Inc. | Vecteur d'adenovirus specifique des cellules comprenant un promoteur specifique de ebv |
US20050136035A1 (en) * | 2003-06-03 | 2005-06-23 | Derek Ko | Cell specific replication-competent viral vectors comprising a self processing peptide cleavage site |
ES2292271B1 (es) * | 2004-05-20 | 2009-02-16 | Proyecto De Biomedicina Cima, S.L. | Un vector hibrido adenovirus-alfavirus para la administracion eficaz y expresion de genes terapeuticos en celulas tumorales. |
EP1900749A1 (fr) * | 2006-09-12 | 2008-03-19 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Acide nucléique pour l'expression d'un polynucléotide d'interêt dans des cellules cancéreuses de mammiferès |
US10173074B2 (en) * | 2012-10-24 | 2019-01-08 | The Regents Of The University Of Michigan | Cancer stem cell vaccination and treatment |
CN112980884A (zh) * | 2021-03-03 | 2021-06-18 | 北京中因科技有限公司 | 一种提高腺相关病毒感染细胞感染效率的方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6638762B1 (en) * | 1994-11-28 | 2003-10-28 | Genetic Therapy, Inc. | Tissue-vectors specific replication and gene expression |
US20020051767A1 (en) * | 1995-09-13 | 2002-05-02 | Yawen L. Chiang | Cancer treatment |
AU744725B2 (en) * | 1997-03-03 | 2002-02-28 | Cold Genesys, Inc. | Adenovirus vectors containing heterologous transcription regulatory elements and methods of using same |
WO1998039467A2 (fr) * | 1997-03-03 | 1998-09-11 | Calydon, Inc. | Vecteurs d'adenovirus specifiques de cellules exprimant l'antigene carcino-embrionnaire et leurs methodes d'utilisation |
US20010006633A1 (en) * | 1998-05-15 | 2001-07-05 | David Kirn | Adenovirus-chemotherapeutic combination for treating cancer |
US6900049B2 (en) * | 1998-09-10 | 2005-05-31 | Cell Genesys, Inc. | Adenovirus vectors containing cell status-specific response elements and methods of use thereof |
US6495130B1 (en) * | 1998-12-30 | 2002-12-17 | Calydon, Inc. | Target cell-specific adenoviral vectors containing E3 and methods of use thereof |
-
2001
- 2001-03-21 CA CA002404060A patent/CA2404060A1/fr not_active Abandoned
- 2001-03-21 JP JP2001570302A patent/JP2003532638A/ja not_active Withdrawn
- 2001-03-21 EP EP01916717A patent/EP1318839A2/fr not_active Withdrawn
- 2001-03-21 AU AU2001243704A patent/AU2001243704B2/en not_active Ceased
- 2001-03-21 AU AU4370401A patent/AU4370401A/xx active Pending
- 2001-03-21 WO PCT/US2001/009042 patent/WO2001072341A2/fr active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
AU2001243704B2 (en) | 2005-10-27 |
WO2001072341A3 (fr) | 2003-03-20 |
AU4370401A (en) | 2001-10-08 |
JP2003532638A (ja) | 2003-11-05 |
EP1318839A2 (fr) | 2003-06-18 |
WO2001072341A2 (fr) | 2001-10-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US7276233B2 (en) | Methods of treating neoplasia with combinations of target cell-specific adenovirus and chemotherapy | |
US6692736B2 (en) | Cell-specific adenovirus vectors comprising an internal ribosome entry site | |
CA2343135C (fr) | Vecteurs d'adenovirus contenant des elements de reponse specifiques de l'etat des cellules, et procedes d'utilisation desdits vecteurs | |
US6495130B1 (en) | Target cell-specific adenoviral vectors containing E3 and methods of use thereof | |
US6676935B2 (en) | Tissue specific adenoviral vectors | |
US6432700B1 (en) | Adenovirus vectors containing heterologous transcription regulatory elements and methods of using same | |
AU744725B2 (en) | Adenovirus vectors containing heterologous transcription regulatory elements and methods of using same | |
US7048920B2 (en) | Recombinant oncolytic adenovirus for human melanoma | |
US6254862B1 (en) | Adenovirus vectors specific for cells expressing alpha-fetoprotein and methods of use thereof | |
US20030026792A1 (en) | Adenovirus vectors specific for cells expressing carcinoembryonic antigen and methods of use thereof | |
US20170190752A1 (en) | E1-minus adenoviruses and use thereof | |
KR101527213B1 (ko) | 동물 세포에서 다중 내성을 역전시키기 위한 방법 | |
WO1998039464A9 (fr) | Vecteurs d'adenovirus contenant des elements heterologues regulateurs de transcription, et leur procede d'utilisation | |
US20090270485A1 (en) | Cell specific replication-competent viral vectors comprising a self processing peptide cleavage site | |
AU2001247648B2 (en) | Cell-specific adenovirus vectors comprising an internal ribosome entry site | |
US20030152553A1 (en) | Compositions comprising tissue specific adenoviral vectors | |
EP1268761B1 (fr) | Sequences de regulation transcriptionnelle d'uroplakine specifiques aux cellules urotheliales humaines, vecteurs comportant des sequences de regulation transcriptionnelle specifiques a l'uroplakine, et leur procedes d'utilisation | |
AU2001247648A1 (en) | Cell-specific adenovirus vectors comprising an internal ribosome entry site | |
AU2001243704B2 (en) | Methods of treating neoplasia with combinations of target cell-specific adenovirus, chemotherapy and radiation | |
AU2001243704A1 (en) | Methods of treating neoplasia with combinations of target cell-specific adenovirus, chemotherapy and radiation | |
WO1999044423A1 (fr) | Amplification d'un echange genique et traitement genique au moyen d'une replication regulee | |
CA2516652A1 (fr) | Systeme pour la commande externe de la reproduction d'un virus oncolytique | |
US20040241857A1 (en) | Tissue specific adenoviral vectors |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Dead |