CA2403200A1 - Solution et structures cristallines de zipa et de complexe de zipa ainsi que leurs utilisations - Google Patents

Solution et structures cristallines de zipa et de complexe de zipa ainsi que leurs utilisations Download PDF

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Publication number
CA2403200A1
CA2403200A1 CA002403200A CA2403200A CA2403200A1 CA 2403200 A1 CA2403200 A1 CA 2403200A1 CA 002403200 A CA002403200 A CA 002403200A CA 2403200 A CA2403200 A CA 2403200A CA 2403200 A1 CA2403200 A1 CA 2403200A1
Authority
CA
Canada
Prior art keywords
atom
zipa
beta
amino acid
acid residues
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002403200A
Other languages
English (en)
Inventor
Elizabeth Dushin
Franklin J. Moy
Robert Powers
Lidia Mosyak
William S. Somers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Wyeth LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth LLC filed Critical Wyeth LLC
Publication of CA2403200A1 publication Critical patent/CA2403200A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne une solution tridimensionnelle et des structures cristallines du domaine C-terminal de ZipA ("ZipA¿185-328?"), ainsi que la structure cristalline tridimensionnelle de ZipA¿185-328? complexé à une région C-terminale de FtsZ. Ces structures sont essentielles pour la conception et la sélection d'inhibiteurs puissants et sélectifs de l'activité du complexe ZipA/FtsZ, notamment en vue d'une utilisation comme agents antibiotiques dirigés contre les bactéries Gram-négatives. La présente invention concerne également des inhibiteurs identifiés au moyen des structures tridimensionnelles susmentionnées.
CA002403200A 2000-03-28 2001-03-26 Solution et structures cristallines de zipa et de complexe de zipa ainsi que leurs utilisations Abandoned CA2403200A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US53677400A 2000-03-28 2000-03-28
US09/536,774 2000-03-28
PCT/US2001/009826 WO2001073436A1 (fr) 2000-03-28 2001-03-26 Solution et structures cristallines de zipa et de complexe de zipa ainsi que leurs utilisations

Publications (1)

Publication Number Publication Date
CA2403200A1 true CA2403200A1 (fr) 2001-10-04

Family

ID=24139878

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002403200A Abandoned CA2403200A1 (fr) 2000-03-28 2001-03-26 Solution et structures cristallines de zipa et de complexe de zipa ainsi que leurs utilisations

Country Status (4)

Country Link
EP (1) EP1272845A4 (fr)
AU (1) AU2001249518A1 (fr)
CA (1) CA2403200A1 (fr)
WO (1) WO2001073436A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002328231A1 (en) * 2001-09-24 2003-04-07 Affinium Pharmaceuticals, Inc. Novel purified polypeptides involved in membrane biosynthesis
AU2002364783A1 (en) * 2001-11-21 2003-06-10 Affinium Pharmaceuticals, Inc. Purified polypeptides involved in general metabolism

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5948889A (en) * 1996-05-21 1999-09-07 Case Western Reserve University Compositions and methods for screening antimicrobials

Also Published As

Publication number Publication date
AU2001249518A1 (en) 2001-10-08
EP1272845A4 (fr) 2003-09-10
EP1272845A1 (fr) 2003-01-08
WO2001073436A1 (fr) 2001-10-04

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Legal Events

Date Code Title Description
FZDE Discontinued
FZDE Discontinued

Effective date: 20040329