CA2395289A1 - Administration transdermique de phenylpropanolamine - Google Patents

Administration transdermique de phenylpropanolamine Download PDF

Info

Publication number
CA2395289A1
CA2395289A1 CA002395289A CA2395289A CA2395289A1 CA 2395289 A1 CA2395289 A1 CA 2395289A1 CA 002395289 A CA002395289 A CA 002395289A CA 2395289 A CA2395289 A CA 2395289A CA 2395289 A1 CA2395289 A1 CA 2395289A1
Authority
CA
Canada
Prior art keywords
hydroxide
drug
phenylpropanolamine
releasing agent
ppa
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002395289A
Other languages
English (en)
Inventor
Tsung-Min Hsu
Eric C. Luo
Russell Macy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dermatrends Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/738,393 external-priority patent/US6602912B2/en
Priority claimed from US09/738,410 external-priority patent/US6586000B2/en
Application filed by Individual filed Critical Individual
Publication of CA2395289A1 publication Critical patent/CA2395289A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne des procédés et des systèmes d'administration transdermique de phénylpropanolamine racémique, c'est-à-dire un mélange d'au moins deux des quatre isomères de phénylpropanolamine, (+)-noréphédrine, (-)-noréphédrine, (+)-norpseudoéphédrine et (-)-norpseudoéphédrine. D'une manière générale, le racémate sera un mélange de (+)-noréphédrine et (-)-noréphédrine. Le médicament racémique est administré avec un agent favorisant la perméation, lequel agent est, de préférence, un composé basique, et, d'une manière optimale, un agent libérant de l'hydroxyde, par exemple l'hydroxyde de sodium.
CA002395289A 1999-12-16 2000-12-15 Administration transdermique de phenylpropanolamine Abandoned CA2395289A1 (fr)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US46509899A 1999-12-16 1999-12-16
US09/465,098 1999-12-16
US60789200A 2000-06-30 2000-06-30
US09/607,892 2000-06-30
US09/738,393 US6602912B2 (en) 2000-06-30 2000-12-14 Transdermal administration of phenylpropanolamine
US09/738,410 2000-12-14
US09/738,393 2000-12-14
US09/738,410 US6586000B2 (en) 1999-12-16 2000-12-14 Hydroxide-releasing agents as skin permeation enhancers
PCT/US2000/034091 WO2001043734A2 (fr) 1999-12-16 2000-12-15 Administration transdermique de phenylpropanolamine

Publications (1)

Publication Number Publication Date
CA2395289A1 true CA2395289A1 (fr) 2001-06-21

Family

ID=27504102

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002395289A Abandoned CA2395289A1 (fr) 1999-12-16 2000-12-15 Administration transdermique de phenylpropanolamine

Country Status (5)

Country Link
EP (1) EP1239846A2 (fr)
JP (1) JP2003528045A (fr)
AU (1) AU2727801A (fr)
CA (1) CA2395289A1 (fr)
WO (1) WO2001043734A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20050059072A (ko) * 2002-08-30 2005-06-17 알자 코포레이션 엠보싱 및 기록가능한 다층 지지 구조물
US20050244485A1 (en) * 2003-10-14 2005-11-03 Tsung-Min Hsu Transdermal administration of hydrophilic drugs using a basic permeation enhancer composition
JP5485135B2 (ja) 2008-02-27 2014-05-07 久光製薬株式会社 貼付製剤
WO2009107478A1 (fr) 2008-02-27 2009-09-03 久光製薬株式会社 Timbre transdermique adhésif et produit conditionné
JP2012504616A (ja) * 2008-10-02 2012-02-23 トゥルーテック コープ． 静電気を防止するための皮膚用製品及びその方法
DE102009022915A1 (de) * 2009-05-27 2010-12-09 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches System mit gesteuertem Wirkstofffluss

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4291015A (en) * 1979-08-14 1981-09-22 Key Pharmaceuticals, Inc. Polymeric diffusion matrix containing a vasodilator
CA1163559A (fr) * 1980-07-09 1984-03-13 Alec D. Keith Matrice polymerique pour l'administration de medicaments par diffusion
US4781924A (en) * 1987-11-09 1988-11-01 Alza Corporation Transdermal drug delivery device
DE3843237A1 (de) * 1988-12-22 1990-07-05 Lohmann Therapie Syst Lts Transdermales therapeutisches system mit einem antiadipositum als aktivem bestandteil
US5498417A (en) * 1994-05-12 1996-03-12 Coating Sciences, Inc. Transdermal delivery of appetite suppressant drug

Also Published As

Publication number Publication date
WO2001043734A2 (fr) 2001-06-21
AU2727801A (en) 2001-06-25
JP2003528045A (ja) 2003-09-24
EP1239846A2 (fr) 2002-09-18
WO2001043734A3 (fr) 2002-01-03

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Legal Events

Date Code Title Description
FZDE Dead