CA2393699A1 - Composes d'ammonium quaternaire et leur utilisation comme agent antitussif - Google Patents

Composes d'ammonium quaternaire et leur utilisation comme agent antitussif Download PDF

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Publication number
CA2393699A1
CA2393699A1 CA002393699A CA2393699A CA2393699A1 CA 2393699 A1 CA2393699 A1 CA 2393699A1 CA 002393699 A CA002393699 A CA 002393699A CA 2393699 A CA2393699 A CA 2393699A CA 2393699 A1 CA2393699 A1 CA 2393699A1
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CA
Canada
Prior art keywords
formula
pharmaceutically acceptable
represented
compound
integer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002393699A
Other languages
English (en)
Inventor
Clive P. Page
Lewis Siu Leung Choi
Gregory N. Beatch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB Farchim SA
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CA002393699A priority Critical patent/CA2393699A1/fr
Priority claimed from PCT/CA2000/001508 external-priority patent/WO2001044167A1/fr
Publication of CA2393699A1 publication Critical patent/CA2393699A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un mode de réalisation de la présente invention concerne l'utilisation de certains composés d'ammonium quaternaire comme substance active intervenant dans la fabrication d'un médicament servant au traitement et/ou à la prévention de la toux chez des animaux à sang chaud, y compris chez l'être humain, les composés étant représentés par la formule (I), dans laquelle J est indépendamment choisi parmi un représenté par l'une des formules (II), (III) et (IV).
CA002393699A 1999-12-15 2000-12-15 Composes d'ammonium quaternaire et leur utilisation comme agent antitussif Abandoned CA2393699A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002393699A CA2393699A1 (fr) 1999-12-15 2000-12-15 Composes d'ammonium quaternaire et leur utilisation comme agent antitussif

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CA2,292,343 1999-12-15
CA2292343 1999-12-15
PCT/CA2000/001508 WO2001044167A1 (fr) 1999-12-15 2000-12-15 Composes d'ammonium quaternaire et leur utilisation comme agent antitussif
CA002393699A CA2393699A1 (fr) 1999-12-15 2000-12-15 Composes d'ammonium quaternaire et leur utilisation comme agent antitussif

Publications (1)

Publication Number Publication Date
CA2393699A1 true CA2393699A1 (fr) 2001-06-21

Family

ID=25681401

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002393699A Abandoned CA2393699A1 (fr) 1999-12-15 2000-12-15 Composes d'ammonium quaternaire et leur utilisation comme agent antitussif

Country Status (1)

Country Link
CA (1) CA2393699A1 (fr)

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Legal Events

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FZDE Dead