CA2389600A1 - Novel human melastatin-like proteins and polynucleotides encoding the same - Google Patents

Abstract

Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.

Description

NOVEL HUMAN MELASTATIN-LIKE PROTEINS AND
POLYNUCLEOTIDES ENCODING THE SAME
The present application claims the benefit of U.S.
Provisional Application Number 60/162,678 which was filed on November 1, 1999 and is herein incorporated by reference in its entirety.
1. INTRODUCTION
The present invention relates to the discovery, identification, and characterization of novel human polynucleotides encoding proteins that share sequence similarity with mammalian tumor progression inhibitor proteins. The invention encompasses the described polynucleotides, host cell expression systems, the encoded proteins, fusion proteins, polypeptides and peptides, antibodies to the encoded proteins and peptides, and genetically engineered animals that either lack or over express the disclosed genes, antagonists and agonists of the proteins, and other compounds that modulate the expression or activity of the proteins encoded by the disclosed genes that can be used for diagnosis, drug screening, clinical trial monitoring and the treatment of physiological disorders.

2. BACKGROUND OF THE INVENTION
Tumor progression inhibitors (TPI) include genes whose expression is inversely correlated with tumor aggressiveness.
Given the therapeutic importance of tumor aggressiveness, TPI
proteins like melastatin have been associated tumor growth, spread, and metastasis.

3. SUMMARY OF THE INVENTION
The present invention relates to the discovery, identification, and characterization of nucleotides that encode novel human proteins, and the corresponding amino acid sequences of these proteins. The novel human proteins (NHPs) described for the first time herein share structural similarity with mammalian melastatin proteins.

The novel human nucleic acid sequences described herein, encode alternative proteins/open reading frames (ORFs) of 803, 823, 948, 1,134, 1,197, 1,579, 778, 798, 923, 1,109, 1,172, 1,554, 793, 813, 938, 1,124, 1,187, 1,569, 768, 788, 913, 1,099, 1,162, 1,544, 366, 386, 511, 697, 760, 1,142, 356, 376, 501, 687, 750, 1,132, 89, 127, 108, 12, 74, and 25 amino acids in length (see SEQ ID NOS: 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68, 70, 72, 74, 76, 78, 80, 82, and 84 respectively).
The invention also encompasses agonists and antagonists of the described NHPs, including small molecules, large molecules, mutant NHPs, or portions thereof that compete with native NHP, peptides, and antibodies, as well as nucleotide sequences that can be used to inhibit the expression of the described NHPs (e.g., antisense and ribozyme molecules, and gene or regulatory sequence replacement constructs) or to enhance the expression of the described NHP sequences (e. g., expression constructs that place the described gene under the control of a strong promoter system), and transgenic animals that express a NHP transgene, or "knock-outs" (which can be conditional) that do not express a functional NHP. A knockout ES cell line has been produced that contains a gene trap mutation in the murine ortholog of the described gene.
Further, the present invention also relates to processes for identifying compounds that modulate, i.e., act as agonists or antagonists, of NHP expression and/or NHP activity that utilize purified preparations of the described NHPs and/or NHP
product, or cells expressing the same. Such compounds can be used as therapeutic agents for the treatment of any of a wide variety of symptoms associated with biological disorders or imbalances.

4. DESCRIPTION OF THE SEQUENCE LISTING AND FIGURES
The Sequence Listing provides the sequences of the described NHP ORFs that encode the described NHP amino acid sequences. SEQ ID N0:85 describes a full length NHP ORF as well as flanking 5' and 3' sequences.

5. DETAILED DESCRIPTION OF THE INVENTION
The NHPs, described for the first time herein, are novel proteins that are expressed in, inter alia, human cell lines, and in adult brain, pituitary, prostate, thymus, thyroid, testis, kidney, and gene trapped human cells.
The present invention encompasses the nucleotides presented in the Sequence Listing, host cells expressing such nucleotides, the expression products of such nucleotides, and:
(a) nucleotides that encode mammalian homologs of the described sequences, including the specifically described NHPs, and the NHP products; (b) nucleotides that encode one or more portions of the NHPs that correspond to functional domains, and the polypeptide products specified by such nucleotide sequences, including but not limited to the novel regions of any active domain(s); (c) isolated nucleotides that encode mutant versions, engineered or naturally occurring, of the described NHPs in which all or a part of at least one domain is deleted or altered, and the polypeptide products specified by such nucleotide sequences, including but not limited to soluble proteins and peptides in which all or a portion of the signal sequence in deleted; (d) nucleotides that encode chimeric fusion proteins containing all or a portion of a coding region of an NHP, or one of its domains (e. g., a receptor or ligand binding domain, accessory protein/self-association domain, etc.) fused to another peptide or polypeptide; or (e) therapeutic or diagnostic derivatives of the described polynucleotides such as oligonucleotides, antisense polynucleotides, ribozymes, dsRNA, or gene therapy constructs comprising a sequence first disclosed in the Sequence Listing.
As discussed above, the present invention includes:
(a) the human DNA sequences presented in the Sequence Listing (and vectors comprising the same) and additionally contemplates any nucleotide sequence encoding a contiguous NHP

open reading frame (ORF) that hybridizes to a complement of a DNA sequence presented in the Sequence Listing under highly stringent conditions, e.g., hybridization to filter-bound DNA
in 0.5 M NaHP04, 7o sodium dodecyl sulfate (SDS), 1 mM EDTA at 65°C, and washing in 0.lxSSC/0.1o SDS at 68°C (Ausubel F.M. et al., eds., 1989, Current Protocols in Molecular Biology, Vol.
I, Green Publishing Associates, Inc., and John Wiley & sons, Inc., New York, at p. 2.10.3) and encodes a functionally equivalent gene product. Additionally contemplated are any nucleotide sequences that hybridize to the complement of the DNA sequence that encode and express an amino acid sequence presented in the Sequence Listing under moderately stringent conditions, e.g., washing in 0.2xSSC/0.1o SDS at 42°C (Ausubel et al., 1989, supra), yet still encode a functionally equivalent NHP product. Functional equivalents of a NHP
include naturally occurring NHPs present in other species and mutant NHPs whether naturally occurring or engineered (by site directed mutagenesis, gene shuffling, directed evolution as described in, for example, U.S. Patent No. 5,837,458). The invention also includes degenerate nucleic acid variants of the disclosed NHP polynucleotide sequences.
Additionally contemplated are polynucleotides encoding NHP ORFs, or their functional equivalents, encoded by polynucleotide sequences that are about 99, 95, 90, or about 85 percent similar or identical to corresponding regions of the nucleotide sequences of the Sequence Listing (as measured by BLAST sequence comparison analysis using, for example, the GCG sequence analysis package using standard default settings).
The invention also includes nucleic acid molecules, preferably DNA molecules, that hybridize to, and are therefore the complements of, the described NHP nucleotide sequences.
Such hybridization conditions may be highly stringent or less highly stringent, as described above. In instances where the nucleic acid molecules are deoxyoligonucleotides ("DNA
oligos"), such molecules are generally about 16 to about 100 bases long, or about 20 to about 80, or about 34 to about 45 bases long, or any variation or combination of sizes represented therein that incorporate a contiguous region of sequence first disclosed in the Sequence Listing. Such oligonucleotides can be used in conjunction with the polymerase chain reaction (PCR) to screen libraries, isolate clones, and prepare cloning and sequencing templates, etc..
Alternatively, such NHP oligonucleotides can be used as hybridization probes for screening libraries, and assessing gene expression patterns (particularly using a micro array or high-throughput "chip" format). Additionally, a series of the described NHP oligonucleotide sequences, or the complements thereof, can be used to represent all or a portion of the described NHP sequences. The oligonucleotides, typically between about 16 to about 40 (or any whole number within the stated range) nucleotides in length can partially overlap each other and/or the NHP sequence may be represented using oligonucleotides that do not overlap. Accordingly, the described NHP polynucleotide sequences shall typically comprise at least about two or three distinct oligonucleotide sequences of at least about 18, and preferably about 25, nucleotides in length that are each first disclosed in the described Sequence Listing. Such oligonucleotide sequences may begin at any nucleotide present within a sequence in the Sequence Listing and proceed in either a sense (5'-to-3') orientation vis-a-vis the described sequence or in an antisense orientation.
For oligonucleotide probes, highly stringent conditions may refer, e.g., to washing in 6xSSC/0.05o sodium pyrophosphate at 37°C (for 14-base oligos), 48°C (for 17-base oligos), 55°C (for 20-base oligos), and 60°C (for 23-base oligos). These nucleic acid molecules may encode or act as NHP gene antisense molecules, useful, for example, in NHP gene regulation (for and/or as antisense primers in amplification reactions of NHP nucleic acid sequences). With respect to NHP
gene regulation, such techniques can be used to regulate biological functions. Further, such sequences may be used as part of ribozyme and/or triple helix sequences that are also useful for NHP gene regulation.
Inhibitory antisense or double stranded oligonucleotides can additionally comprise at least one modified base moiety which is selected from the group including but not limited to 5-fluorouracil, 5-bromouracil, 5-chlorouracil, 5-iodouracil, hypoxanthine, xantine, 4-acetylcytosine, 5-(carboxyhydroxylmethyl) uracil, 5-carboxymethylaminomethyl-2-thiouridine, 5-carboxymethylaminomethyluracil, dihydrouracil, beta-D-galactosylqueosine, inosine, N6-isopentenyladenine, 1-methylguanine, 1-methylinosine, 2,2-dimethylguanine, 2-methyladenine, 2-methylguanine, 3-methylcytosine, 5-methylcytosine, N6-adenine, 7-methylguanine, 5-methylaminomethyluracil, 5-methoxyaminomethyl-2-thiouracil, beta-D-mannosylqueosine, 5'-methoxycarboxymethyluracil, 5-methoxyuracil, 2-methylthio-N6-isopentenyladenine, uracil-5-oxyacetic acid (v), wybutoxosine, pseudouracil, queosine, 2-thiocytosine, 5-methyl-2-thiouracil, 2-thiouracil, 4-thiouracil, 5-methyluracil, uracil-5-oxyacetic acid methylester, uracil-5-oxyacetic acid (v), 5-methyl-2-thiouracil, 3-(3-amino-3-N-2-carboxypropyl) uracil, (acp3)w, and 2,6-diaminopurine.
The antisense oligonucleotide can also comprise at least one modified sugar moiety selected from the group including but not limited to arabinose, 2-fluoroarabinose, xylulose, and hexose.
In yet another embodiment, the antisense oligonucleotide will comprise at least one modified phosphate backbone selected from the group consisting of a phosphorothioate, a phosphorodithioate, a phosphoramidothioate, a phosphoramidate, a phosphordiamidate, a methylphosphonate, an alkyl phosphotriester, and a formacetal or analog thereof.
In yet another embodiment, the antisense oligonucleotide is an a-anomeric oligonucleotide. An a-anomeric oligonucleotide forms specific double-stranded hybrids with complementary RNA in which, contrary to the usual (3-units, the strands run parallel to each other (Gautier et al., 1987, Nucl. Acids Res. 15:6625-6641). The oligonucleotide is a 2'-0-methylribonucleotide ( moue et al., 1987, Nucl. Acids Res.
15:6131-6148), or a chimeric RNA-DNA analogue ( moue et al., 1987, FEBS Lett. 215:327-330). Alternatively, double stranded RNA can be used to disrupt the expression and function of a targeted NHP.
Oligonucleotides of the invention can be synthesized by standard methods known in the art, e.g. by use of an automated DNA synthesizer (such as are commercially available from Biosearch, Applied Biosystems, etc.). As examples, phosphorothioate oligonucleotides can be synthesized by the method of Stein et al. (1988, Nucl. Acids Res. 16:3209), and methylphosphonate oligonucleotides can be prepared by use of controlled pore glass polymer supports (Sarin et al., 1988, Proc. Natl. Acad. Sci. U.S.A. 85:7448-7451), etc.
Low stringency conditions are well known to those of skill in the art, and will vary predictably depending on the specific organisms from which the library and the labeled sequences are derived. For guidance regarding such conditions see, for example, Sambrook et al., 1989, Molecular Cloning, A
Laboratory Manual (and periodic updates thereof), Cold Springs Harbor Press, N.Y.; and Ausubel et al., 1989, Current Protocols in Molecular Biology, Green Publishing Associates and Wiley Interscience, N.Y.
Alternatively, suitably labeled NHP nucleotide probes can be used to screen a human genomic library using appropriately stringent conditions or by PCR. The identification and characterization of human genomic clones is helpful for identifying polymorphisms (including, but not limited to, nucleotide repeats, microsatellite alleles, single nucleotide polymorphisms, or coding single nucleotide polymorphisms), determining the genomic structure of a given locus/allele, and designing diagnostic tests. For example, sequences derived from regions adjacent to the intron/exon boundaries of the human gene can be used to design primers for use in amplification assays to detect mutations within the exons, introns, splice sites (e. g., splice acceptor and/or donor sites), etc., that can be used in diagnostics and pharmacogenomics.
Further, a NHP gene homolog can be isolated from nucleic acid from an organism of interest by performing PCR using two degenerate or "wobble" oligonucleotide primer pools designed on the basis of amino acid sequences within the NHP products disclosed herein. The template for the reaction may be total RNA, mRNA, and/or cDNA obtained by reverse transcription of mRNA prepared from human or non-human cell lines or tissue known or suspected to express an allele of a NHP gene.
The PCR product can be subcloned and sequenced to ensure that the amplified sequences represent the sequence of the desired NHP gene. The PCR fragment can then be used to isolate a full length cDNA clone by a variety of methods. For example, the amplified fragment can be labeled and used to screen a cDNA library, such as a bacteriophage cDNA library.
Alternatively, the labeled fragment can be used to isolate genomic clones via the screening of a genomic library.
PCR technology can also be used to isolate full length cDNA sequences. For example, RNA can be isolated, following standard procedures, from an appropriate cellular or tissue source (i.e., one known, or suspected, tb express a NHP gene).
A reverse transcription (RT) reaction can be performed on the RNA using an oligonucleotide primer specific for the most 5' end of the amplified fragment for the priming of first strand synthesis. The resulting RNA/DNA hybrid may then be "tailed"
using a standard terminal transferase reaction, the hybrid may be digested with RNase H, and second strand synthesis may then be primed with a complementary primer. Thus, cDNA sequences upstream of the amplified fragment can be isolated. For a review of cloning strategies that can be used, see e.g., Sambrook et al., 1989, supra.
A cDNA encoding a mutant NHP gene can be isolated, for example, by using PCR. In this case, the first cDNA strand may be synthesized by hybridizing an oligo-dT oligonucleotide to mRNA isolated from tissue known or suspected to be expressed in an individual putatively carrying a mutant NHP

allele, and by extending the new strand with reverse transcriptase. The second strand of the cDNA is then synthesized using an oligonucleotide that hybridizes specifically to the 5' end of the normal gene. Using these two primers, the product is then amplified via PCR, optionally cloned into a suitable vector, and subjected to DNA sequence analysis through methods well known to those of skill in the art. By comparing the DNA sequence of the mutant NHP allele to that of a corresponding normal NHP allele, the mutations) responsible for the loss or alteration of function of the mutant NHP gene product can be ascertained.
Alternatively, a genomic library can be constructed using DNA obtained from an individual suspected of or known to carry a mutant NHP allele (e. g., a person manifesting a NHP-associated phenotype such as, for example, obesity, high blood pressure, connective tissue disorders, infertility, etc.), or a cDNA library can be constructed using RNA from a tissue known, or suspected, to express a mutant NHP allele. A normal NHP gene, or any suitable fragment thereof, can then be labeled and used as a probe to identify the corresponding mutant NHP allele in such libraries. Clones containing mutant NHP sequences can then be purified and subjected to sequence analysis according to methods well known to those skilled in the art.
Additionally, an expression library can be constructed utilizing cDNA synthesized from, for example, RNA isolated from a tissue known, or suspected, to express a mutant NHP
allele in an individual suspected of or known to carry such a mutant allele. In this manner, gene products made by the putatively mutant tissue can be expressed and screened using standard antibody screening techniques in conjunction with antibodies raised against a normal NHP product, as described below. (For screening techniques, see, for example, Harlow, E. and Lane, eds., 1988, "Antibodies: A Laboratory Manual", Cold Spring Harbor Press, Cold Spring Harbor.) Additionally, screening can be accomplished by screening with labeled NHP fusion proteins, such as, alkaline phosphatase-NHP

or NHP-alkaline phosphatase fusion proteins. In cases where a NHP mutation results in an expressed gene product with altered function (e. g., as a result of a missense or a frameshift mutation), polyclonal antibodies to a NHP are likely to cross-react with a corresponding mutant NHP gene product. Library clones detected via their reaction with such labeled antibodies can be purified and subjected to sequence analysis according to methods well known in the art.
The invention also encompasses (a) DNA vectors that contain any of the foregoing NHP coding sequences and/or their complements (i.e., antisense); (b) DNA expression vectors that contain any of the foregoing NHP coding sequences operatively associated with a regulatory element that directs the expression of the coding sequences (for example, baculo virus as described in U.S. Patent No. 5,869,336 herein incorporated by reference); (c) genetically engineered host cells that contain any of the foregoing NHP coding sequences operatively associated with a regulatory element that directs the expression of the coding sequences in the host cell; and (d)' genetically engineered host cells that express an endogenous NHP gene under the control of an exogenously introduced regulatory element (i.e., gene activation). As used herein, regulatory elements include, but are not limited to, inducible and non-inducible promoters, enhancers, operators and other elements known to those skilled in the art that drive and regulate expression. Such regulatory elements include but are not limited to the human cytomegalovirus (hCMV) immediate early gene, regulatable, viral elements (particularly retroviral LTR promoters), the early or late promoters of SV40 adenovirus, the lac system, the trp system, the TAC system, the TRC system, the major operator and promoter regions of phage lambda, the control regions of fd coat protein, the promoter for 3-phosphoglycerate kinase (PGK), the promoters of acid phosphatase, and the promoters of the yeast a-mating factors.
The present invention also encompasses antibodies and anti-idiotypic antibodies (including Fab fragments), antagonists and agonists of the NHP, as well as compounds or nucleotide constructs that inhibit expression of a NHP gene (transcription factor inhibitors, antisense and ribozyme molecules, or gene or regulatory sequence replacement constructs), or promote the expression of a NHP (e. g., expression constructs iri which NHP coding sequences are operatively associated with expression control elements such as promoters, promoter/enhancers, etc.).
The NHPs or NHP peptides, NHP fusion proteins, NHP
nucleotide sequences, antibodies, antagonists and agonists can be useful for the detection of mutant NHPs or inappropriately expressed NHPs for the diagnosis of disease. The NHP proteins or peptides, NHP fusion proteins, NHP nucleotide sequences, host cell expression systems, antibodies, antagonists, agonists and genetically engineered cells and animals can be used for screening for drugs (or high throughput screening of combinatorial libraries) effective in the treatment of the symptomatic or phenotypic manifestations of perturbing the normal function of NHP in the body. The use of engineered host cells and/or animals may offer an advantage in that such systems allow not only for the identification of compounds that bind to the endogenous receptor for an NHP, but can also identify compounds that trigger NHP-mediated activities or pathways.
Finally, the NHP products can be used as therapeutics.
For example, soluble derivatives such as NHP peptides/domains corresponding the NHPs, NHP fusion protein products (especially NHP-Ig fusion proteins, i.e., fusions of a NHP, or a domain of a NHP, to an IgFc), NHP antibodies and anti-idiotypic antibodies (including Fab fragments), antagonists or agonists (including compounds that modulate or act on downstream targets in a NHP-mediated pathway) can be used to directly treat diseases or disorders. For instance, the administration of an effective amount of soluble NHP, or a NHP-IgFc fusion protein or an anti-idiotypic antibody (or its Fab) that mimics the NHP could activate or effectively antagonize the endogenous NHP receptor. Nucleotide constructs encoding such NHP products can be used to genetically engineer host cells to express such products in vivo; these genetically engineered cells function as "bioreactors" in the body delivering a continuous supply of a NHP, a NHP peptide, or a NHP fusion protein to the body. Nucleotide constructs encoding functional NHPs, mutant NHPs, as well as antisense and ribozyme molecules can also be used in "gene therapy"
approaches for the modulation of NHP expression.. Thus, the invention also encompasses pharmaceutical formulations and methods for treating biological disorders.
Various aspects of the invention are described in greater detail in the subsections below.
5.1 THE NHP SEQUENCES
The cDNA sequences and the corresponding deduced amino acid sequences of the described NHPs are presented in the Sequence Listing. The NHP nucleotides were obtained from clustered human gene trapped sequences, ESTs, and kidney cDNA
libraries (Edge Biosystems, Gaithersburg, MD). Similar sequences, as well as uses and applications that are germane to the described sequences, are described in U.S. Patent No.
5,674,739 which is herein incorporated by reference in its entirety.
5.2 NHPS AND NHP POLYPEPTIDES
NHPs, polypeptides, peptide fragments, mutated, truncated, or deleted forms of the NHPs, and/or NHP fusion proteins can be prepared for a variety of uses. These uses include, but are not limited to, the generation of antibodies, as reagents in diagnostic assays, for the identification of other cellular gene products related to a NHP, as reagents in assays for screening for compounds that can be as pharmaceutical reagents useful in the therapeutic treatment of mental, biological, or medical disorders and disease.
The Sequence Listing discloses the amino acid sequences encoded by the described NHP genes. The NHPs typically display have initiator methionines in DNA sequence contexts consistent with a translation initiation site.
The NHP amino acid sequences of the invention include the amino acid sequence presented in the Sequence Listing as well as analogues and derivatives thereof. Further, corresponding NHP homologues from other species are encompassed by the invention. In fact, any NHP protein encoded by the NHP
nucleotide sequences described above are within the scope of the invention, as are any novel polynucleotide sequences encoding all or any novel portion of an amino acid sequence presented in the Sequence Listing. The degenerate nature of the genetic code is well known, and, accordingly, each amino acid presented in the Sequence Listing, is generically representative of the well known nucleic acid "triplet" codon, or in many cases codons, that can encode the amino acid. As such, as contemplated herein, the amino acid sequences presented in the Sequence Listing, when taken together with the genetic code (see, for example, Table 4-1 at page 109 of "Molecular Cell Biology", 1986, J. Darnell et al. eds., Scientific American Books, New York, NY, herein incorporated by reference) are generically representative of all the various permutations and combinations of nucleic acid sequences that can encode such amino acid sequences.
The invention also encompasses proteins that are functionally equivalent to the NHPs encoded by the presently described nucleotide sequences as judged by any of a number of criteria, including, but not limited to, the ability to bind and cleave a substrate of a NHP, or the ability to effect an identical or complementary downstream pathway, or a change in cellular metabolism (e. g., proteolytic activity, ion flux, tyrosine phosphorylation, etc.). Such functionally equivalent NHP proteins include, but are not limited to, additions or substitutions of amino acid residues within the amino acid sequence encoded by the NHP nucleotide sequences described above, but which result in a silent change, thus producing a functionally equivalent gene product. Amino acid substitutions may be made on the basis of similarity in polarity, charge, solubility, hydrophobicity, hydrophilicity, and/or the amphipathic nature of the residues involved. For example, nonpolar (hydrophobic) amino acids include alanine, leucine, isoleucine, valine, proline, phenylalanine, tryptophan, and methionine; polar neutral amino acids include glycine, serine, threonine, cysteine, tyrosine, asparagine, and glutamine; positively charged (basic) amino acids include arginine, lysine, and histidine; and negatively charged (acidic) amino acids include aspartic acid and glutamic acid.
A variety of host-expression vector systems can be used to express the NHP nucleotide sequences of the invention.
Where, as in the present instance, the NHP peptide or polypeptide is thought to be a soluble or secreted molecule, the peptide or polypeptide can be recovered from the culture media. Such expression systems also encompass engineered host cells that express a NHP, or functional equivalent, in situ.
Purification or enrichment of a NHP from such expression systems can be accomplished using appropriate detergents and lipid micelles and methods well known to those skilled in the art. However, such engineered host cells themselves may be used in situations where it is important not only to retain the structural and functional characteristics of the NHP, but to assess biological activity, e.g., in drug screening assays.
The expression systems that may be used for purposes of the invention include but are not limited to microorganisms such as bacteria (e. g., E. coli, B. subtilis) transformed with recombinant bacteriophage DNA, plasmid DNA or cosmid DNA
expression vectors containing NHP nucleotide sequences; yeast (e. g., Saccharomyces, Pichia) transformed with recombinant yeast expression vectors containing NHP nucleotide sequences;
insect cell systems infected with recombinant virus expression vectors (e. g., baculovirus) containing NHP sequences; plant cell systems infected with recombinant virus expression vectors (e. g., cauliflower mosaic virus, CaMV; tobacco mosaic virus, TMV) or transformed with recombinant plasmid expression vectors (e. g., Ti plasmid) containing NHP nucleotide sequences; or mammalian cell systems (e. g., COS, CHO, BHK, 293, 3T3) harboring recombinant expression constructs containing promoters derived from the genome of mammalian cells (e. g., metallothionein promoter) or from mammalian viruses (e. g., the adenovirus late promoter; the vaccinia virus 7.5K promoter).
In bacterial systems, a number of expression vectors may be advantageously selected depending upon the use intended for the NHP product being expressed. For example, when a large quantity of such a protein is to be produced for the generation of pharmaceutical compositions of or containing NHP, or for raising antibodies to a NHP, vectors that direct the expression of high levels of fusion protein products that are readily purified may be desirable. Such vectors include, but are not limited, to the E. coli expression vector pUR278 (Ruther et al., 1983, EMBO J. 2:1791), in which a NHP coding sequence may be ligated individually into the vector in frame with the lacZ coding region so that a fusion protein is produced; pIN vectors (Inouye & Inouye, 1985, Nucleic Acids Res. 13:3101-3109; Van Heeke & Schuster, 1989, J. Biol. Chem.
264:5503-5509); and the like. pGEX vectors (Pharmacia or American Type Culture Collection) can also be used to express foreign polypeptides as fusion proteins with glutathione S-transferase (GST). In general, such fusion proteins are soluble and can easily be purified from lysed cells by adsorption to glutathione-agarose beads followed by elution in the presence of free glutathione. The PGEX vectors are designed to include thrombin or factor Xa protease cleavage sites so that the cloned target gene product can be released from the GST moiety.
In an insect system, Autographa californica nuclear polyhidrosis virus (AcNPV) is used as a vector to express foreign genes. The virus grows in Spodoptera frugiperda cells. A NHP gene coding sequence may be cloned individually into non-essential regions (for example the polyhedrin gene) of the virus and placed under control of an AcNPV promoter (for example the polyhedrin promoter). Successful insertion of NHP gene coding sequence will result in inactivation of the polyhedrin gene and production of non-occluded recombinant virus (i.e., virus lacking the proteinaceous coat coded for by the polyhedrin gene). These recombinant viruses are then used to infect Spodoptera frugiperda cells in which the inserted gene is expressed (e. g., see Smith et al., 1983, J. Virol.
46:584; Smith, U.S. Patent No. 4,215,051).
In mammalian host cells, a number of viral-based expression systems may be utilized. In cases where an adenovirus is used as an expression vector, the NHP nucleotide sequence of interest may be ligated to an adenovirus transcription/translation control complex, e.g., the late promoter and tripartite leader sequence. This chimeric gene may then be inserted in the adenovirus genome by in vitro or in vivo recombination. Insertion in a non-essential region of the viral genome (e.g., region E1 or E3) will result in a recombinant virus that is viable and capable of expressing a NHP product in infected hosts (e. g., See Logan & Shenk, 1984, Proc. Natl. Acad. Sci. USA 81:3655-3659). Specific initiation signals may also be required for efficient translation of inserted NHP nucleotide sequences. These signals include the ATG initiation codon and adjacent sequences. In cases where an entire NHP gene or cDNA, including its own initiation codon and adjacent sequences, is inserted into the appropriate expression vector, no additional translational control signals may be needed. However, in cases where only a portion of a NHP coding sequence is inserted, exogenous translational control signals, including, perhaps, the ATG initiation codon, must be provided. Furthermore, the initiation codon must be in phase with the reading frame of the desired coding sequence to ensure translation of the entire insert. These exogenous translational control signals and initiation codons can be of a variety of origins, both natural and synthetic. The efficiency of expression may be enhanced by the inclusion of appropriate transcription enhancer elements, transcription terminators, etc. (See Bittner et al., 1987, Methods in Enzymol. 153:516-544).

In addition, a host cell strain may be chosen that modulates the expression of the inserted sequences, or modifies and processes the gene product in the specific fashion desired. Such modifications (e.g., glycosylation) and processing (e.g., cleavage) of protein products may be important for the function of the protein. Different host cells have characteristic and specific mechanisms for the post-translational processing and modification of proteins and gene products. Appropriate cell lines or host systems can be chosen to ensure the correct modification and processing of the foreign protein expressed. To this end, eukaryotic host cells which possess the cellular machinery for proper processing of the primary transcript, glycosylation, and phosphorylation of the gene product may be used. Such mammalian host cells include, but are not limited to, CHO, VERO, BHK, HeLa, COS, MDCK, 293, 3T3, WI38, and in particular, human cell lines.
For long-term, high-yield production of recombinant proteins, stable expression is preferred. For example, cell lines which stably express the NHP sequences described above can be engineered. Rather than using expression vectors which contain viral origins of replication, host cells can be transformed with DNA controlled by appropriate expression control elements (e. g., promoter, enhancer sequences, transcription terminators, polyadenylation sites, etc.), and a selectable marker. Following the introduction of the foreign DNA, engineered cells may be allowed to grow for 1-2 days in an enriched media, and then are switched to a selective media.
The selectable marker in the recombinant plasmid confers resistance to the selection and allows cells to stably integrate the plasmid into their chromosomes and grow to form foci which in turn can be cloned and expanded into cell lines.
This method may advantageously be used to engineer cell lines which express the NHP product. Such engineered cell lines may be particularly useful in screening and evaluation of compounds that affect the endogenous activity of the NHP
product.

A number of selection systems may be used, including but not limited to the herpes simplex virus thymidine kinase (Wigler, et al., 1977, Cell 11:223), hypoxanthine-guanine phosphoribosyltransferase (Szybalska & Szybalski, 1962, Proc.
Natl. Acad. Sci. USA 48:2026), and adenine phosphoribosyltransferase (Lowy, et al., 1980, Cell 22:817) genes can be employed in tk-, hgprt- or aprt- cells, respectively. Also, antimetabolite resistance can be used as the basis of selection for the following genes: dhfr, which confers resistance to methotrexate (Wigler, et al., 1980, Natl. Acad. Sci. USA 77:3567; 0'Hare, et al., 1981, Proc.
Natl. Acad. Sci. USA 78:1527); gpt, which confers resistance to mycophenolic acid (Mulligan & Berg, 1981, Proc. Natl. Acad.
Sci. USA 78:2072); neo, which confers resistance to the aminoglycoside G-418 (Colberre-Garapin, et al., 1981, J. Mol.
Biol. 150:1); and hygro, which confers resistance to hygromycin (Santerre, et al., 1984, Gene 30:147).
Alternatively, any fusion protein can be readily purified by utilizing an antibody specific for the fusion protein being expressed. For example, a system described by Janknecht et al. allows for the ready purification of non-denatured fusion proteins expressed in human cell lines (Janknecht, et al., 1991, Proc. Natl. Acad. Sci. USA 88:8972-8976). In this system, the gene of interest is subcloned into a vaccinia recombination plasmid such that the gene's open reading frame is translationally fused to an amino-terminal tag consisting of six histidine residues. Extracts from cells infected with recombinant vaccinia virus are loaded onto Niz+~nitriloacetic acid-agarose columns and histidine-tagged proteins are selectively eluted with imidazole-containing buffers.
5.3 ANTIBODIES TO NHP PRODUCTS
Antibodies that specifically recognize one or more epitopes of a NHP, or epitopes of conserved variants of a NHP, or peptide fragments of a NHP are also encompassed by the invention. Such antibodies include but are not limited to polyclonal antibodies, monoclonal antibodies (mAbs), humanized or chimeric antibodies, single chain antibodies, Fab fragments, F(ab')2 fragments, fragments produced by a Fab expression library, anti-idiotypic (anti-Id) antibodies, and epitope-binding fragments of any of the above.
The antibodies of the invention may be used, for example, in the detection of NHP in a biological sample and may, therefore, be utilized as part of a diagnostic or prognostic technique whereby patients may be tested for abnormal amounts of NHP. Such antibodies may also be utilized in conjunction with, for example, compound screening schemes for the evaluation of the effect of test compounds on expression and/or activity of a NHP gene product. Additionally, such antibodies can be used in conjunction gene therapy to, for example, evaluate the normal and/or engineered NHP-expressing cells prior to their introduction into the patient. Such antibodies may additionally be used as a method for the inhibition of abnormal NHP activity. Thus, such antibodies may, therefore, be utilized as part of treatment methods.
For the production of antibodies, various host animals may be immunized by injection with the NHP, an NHP peptide (e. g., one corresponding the a functional domain of an NHP), truncated NHP polypeptides (NHP in which one or more domains have been deleted), functional equivalents of the NHP or mutated variant of the NHP. Such host animals may include but are not limited to pigs, rabbits, mice, goats, and rats, to name but a few. Various adjuvants may be used to increase the immunological response, depending on the host species, including but not limited to Freund's adjuvant (complete and incomplete), mineral salts such as aluminum hydroxide or aluminum phosphate, surface active substances such as lysolecithin, pluronic polyols, polyanions, peptides, oil emulsions, and potentially useful human adjuvants such as BCG
(bacille Calmette-Guerin) and Corynebacterium parvum.
Alternatively, the immune response could be enhanced by combination and or coupling with molecules such as keyhole limpet hemocyanin, tetanus toxoid, diptheria toxoid, ovalbumin, cholera toxin or fragments thereof. Polyclonal antibodies are heterogeneous populations of antibody molecules derived from the sera of the immunized animals.
Monoclonal antibodies, which are homogeneous populations of antibodies to a particular antigen, can be obtained by any technique which provides for the production of antibody molecules by continuous cell lines in culture. These include, but are not limited to, the hybridoma technique of Kohler and Milstein, (1975, Nature 256:495-497; and U.S. Patent No.
4,376,110), the human B-cell hybridoma technique (Kosbor et al., 1983, Immunology Today 4:72; Cole et al., 1983, Proc.
Natl. Acad. Sci. USA 80:2026-2030), and the EBV-hybridoma technique (Cole et al., 1985, Monoclonal Antibodies And Cancer Therapy, Alan R. Liss, Inc., pp. 77-96). Such antibodies may be of any immunoglobulin class including IgG, IgM, IgE, IgA, IgD and any subclass thereof. The hybridoma producing the mAb of this invention may be cultivated in vitro or in vivo.
Production of high titers of mAbs in vivo makes this the presently preferred method of production.
In addition, techniques developed for the production of "chimeric antibodies" (Morrison et al., 1984, Proc. Natl.
Acad. Sci., 81:6851-6855; Neuberger et al., 1984, Nature, 312:604-608; Takeda et al., 1985, Nature, 314:452-454) by splicing the genes from a mouse antibody molecule of appropriate antigen specificity together with genes from a human antibody molecule of appropriate biological activity can be used. A chimeric antibody is a molecule in which different portions are derived from different animal species, such as those having a variable region derived from a murine mAb and a human immunoglobulin constant region.
Such technologies are described in U.S. Patents Nos. 6,075,181 and 5,877,397 and their respective disclosures which are herein incorporated by reference in their entirety.
Alternatively, techniques described for the production of single chain antibodies (U. S. Patent 4,946,778; Bird, 1988, Science 242:423-426; Huston et al., 1988, Proc. Natl. Acad.
Sci. USA 85:5879-5883; and Ward et al., 1989, Nature 334:544-546) can be adapted to produce single chain antibodies against NHP gene products. Single chain antibodies are formed by linking the heavy and light chain fragments of the Fv region via an amino acid bridge, resulting in a single chain polypeptide.
Antibody fragments which recognize specific epitopes may be generated by known techniques. For example, such fragments include, but are not limited to: the F(ab')2 fragments which can be produced by pepsin digestion of the antibody molecule and the Fab fragments which can be generated by reducing the disulfide bridges of the F(ab')2 fragments. Alternatively, Fab expression libraries may be constructed (Ruse et al., 1989, Science, 246:1275-1281) to allow rapid and easy identification of monoclonal Fab fragments with the desired specificity.
Antibodies to a NHP can, in turn, be utilized to generate anti-idiotype antibodies that "mimic" a given NHP, using techniques well known to those skilled in the art. (See, e.g., Greenspan & Bona, 1993, FASEB J 7(5):437-444; and Nissinoff, 1991, J. Immunol. 147(8):2429-2438). For example antibodies which bind to a NHP domain and competitively inhibit the binding of NHP to its cognate receptor can be used to generate anti-idiotypes that "mimic" the NHP and, therefore, bind and activate or neutralize a receptor. Such anti-idiotypic antibodies or Fab fragments of such anti-idiotypes can be used in therapeutic regimens involving a NHP
signaling pathway.
The present invention is not to be limited in scope by the specific embodiments described herein, which are intended as single illustrations of individual aspects of the invention, and functionally equivalent methods and components are within the scope of the invention. Indeed, various modifications of the invention, in addition to those shown and described herein will become apparent to those skilled in the art from the foregoing description. Such modifications are intended to fall within the scope of the appended claims. All cited publications, patents, and patent applications are herein incorporated by reference in their entirety.

SEQUENCE LISTING
<110> LEXICON GENETICS INCORPORATED
<120> Novel Human Melastatin-Like Proteins and Polynucleotides Encoding the Same <130> LEX-0080-PCT
<150> US 60/162,678 <151> 1999-11-01 <160> 85 <170> FastSEQ for Windows Version 4.0 <210> 1 <211> 2412 <212> DNA
<213> homo sapiens <400>

atgtatgtgcgagtatcttttgatacaaaacctgatctcctcttacacctgatgaccaag 60 gaatggcagttggagcttcccaagcttctcatctctgtccatgggggcctgcagaacttt 120 gaactccagccaaaactcaagcaagtctttgggaaagggctcatcaaagcagcaatgaca 180 actggagcgtggatattcactggaggggttaacacaggtgttattcgtcatgttggcgat 240 gccttgaaggatcatgcctctaagtctcgaggaaagatatgcaccataggtattgccccc 300 tggggaattgtggaaaaccaggaggacctcattggaagagatgttgtccggccataccag 360 accatgtccaatcccatgagcaagctcactgttctcaacagcatgcattcccacttcatt 420 ctggctgacaacgggaccactggaaaatatggagcagaggtgaaacttcgaagacaactg 480 gaaaagcatatttcactccagaagataaacacaagatgcctgccgtttttctctcttgac 540 tcccgcttgttttattcattttggggtagttgccagttagactcagttggaatcggtcaa 600 ggtgttcctgtggtggcactcatagtggaaggaggacccaatgtgatctcgattgttttg 660 gagtaccttcgagacacccctcccgtgccagtggttgtctgtgatgggagtggacgggca 720 tcggacatcctggcctttgggcataaatactcagaagaaggcggactgataaatgaatct 780 ttgagggaccagctgttggtgactatacagaagactttcacatacactcgaacccaagct 840 cagcatctgttcatcatcctcatggagtgcatgaagaagaaggaattgattacggtattt 900 cggatgggatcagaaggacaccaggacattgatttggctatcctgacagctttactcaaa 960 ggagccaatgcctcggccccagaccaactgagcttagctttagcctggaacagagtcgac 1020 atcgctcgcagccagatctttatttacgggcaacagtggccggtgggatctctggagcaa 1080 gccatgttggatgccttagttctggacagagtggattttgtgaaattactcatagagaat 1140 ggagtaagcatgcaccgttttctcaccatctccagactagaggaattgtacaatacgaga 1200 catgggccctcaaatacattgtaccacttggtcagggatgtcaaaaaggggaacctgccc 1260 ccagactacagaatcagcctgattgacatcggcctggtgatcgagtacctgatgggcggg 1320 gcttatcgctgcaactacacgcgcaagcgcttccggaccctctaccacaacctcttcggc 1380 cccaagaggcccaaagccttgaaactgctgggaatggaggatgatattcccttgaggcga 1440 ggaagaaagacaaccaagaaacgtgaagaagaggtggacattgacttggatgatcctgag 1500 atcaaccacttccccttccctttccatgagctcatggtgtgggctgttctcatgaagcgg 1560 cagaagatggccctgttcttctggcagcacggtgaggaggccatggccaaggccctggtg 1620 gcctgcaagctctgcaaagccatggctcatgaggcctctgagaacgacatggttgacgac 1680 atttcccaggagctgaatcacaattccagagactttggccagctggctgtggagctcctg 1740 gaccagtcctacaagcaggacgaacagctggccatgaaactgctgacgtatgagctgaag 1800 aactggagcaacgccacgtgcctgcagcttgccgtggctgccaaacaccgcgacttcatc 1860 gcgcacacgtgcagccagatgctgctcaccgacatgtggatgggccggctccgcatgcgc 1920 aagaactcaggcctcaaggtaattctgggaattctacttcctccttcaattctcagcttg 1980 gagttcaagaacaaagacgacatgccctatatgtctcaggcccaggaaatccacctccaa 2040 gagaaggaggcagaagaaccagagaagcccacaaaggaaaaagaggaagaggacatggag 2100 ctcacagcaatgttgggacgaaacaacggggagtcctccaggaagaaggatgaagaggaa 2160 gttcagagcaagcaccggttaatccccctcggcagaaaaatctatgaattctacaatgca 2220 cccatcgtgaagttctggttctacacactggcgtatatcggatacctgatgctcttcaac 2280 tatatcgtgttagtgaagatggaacgctggccgtccacccaggaatggatcgtaatctcc 2340 tatattttcacccttgttccagctggttgtctgcacttcggtcttcccattcatggtgcc 2400 ttttcttctt ga 2412 <210> 2 <211> 803 <212> PRT
<213> homo sapiens <400> 2 Met Tyr Val Arg Val Ser Phe Asp Thr Lys Pro Asp Leu Leu Leu His Leu Met Thr Lys Glu Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser Val His Gly Gly Leu Gln Asn Phe Glu Leu Gln Pro Lys Leu Lys Gln Val Phe Gly Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp Ile Phe Thr Gly Gly Val Asn Thr Gly Val Ile Arg His Val Gly Asp Ala Leu Lys Asp His Ala Ser Lys Ser Arg Gly Lys Ile Cys Thr Ile Gly Ile Ala Pro Trp Gly Ile Val Glu Asn Gln Glu Asp Leu Ile Gly Arg Asp Val Val Arg Pro Tyr Gln Thr Met Ser Asn Pro Met Ser Lys Leu Thr Val Leu Asn Ser Met His Ser His Phe Ile Leu Ala Asp Asn Gly Thr Thr Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Gln Leu Glu Lys His Ile Ser Leu Gln Lys Ile Asn Thr Arg Cys Leu Pro Phe Phe Ser Leu Asp Ser Arg Leu Phe Tyr Ser Phe Trp Gly Ser Cys Gln Leu Asp Ser Val Gly Ile Gly Gln Gly Val Pro Val Val Ala Leu Ile Val Glu Gly Gly Pro Asn Val Ile Ser Ile Val Leu Glu Tyr Leu Arg Asp Thr Pro Pro Val Pro Val Val Val Cys Asp Gly Ser Gly Arg Ala Ser Asp Ile Leu Ala Phe Gly His Lys Tyr Ser Glu Glu Gly Gly Leu Ile Asn Glu Ser Leu Arg Asp Gln Leu Leu Val Thr Ile Gln Lys Thr Phe Thr Tyr Thr Arg Thr Gln Ala Gln His Leu Phe Ile Ile Leu Met Glu Cys Met Lys Lys Lys Glu Leu Ile Thr Val Phe Arg Met Gly Ser Glu Gly His Gln Asp Ile Asp Leu Ala Ile Leu Thr Ala Leu Leu Lys Gly Ala Asn Ala Ser Ala Pro Asp Gln Leu Ser Leu Ala Leu Ala Trp Asn Arg Val Asp Ile Ala Arg Ser Gln Ile Phe Ile Tyr Gly Gln Gln Trp Pro Val Gly Ser Leu Glu Gln Ala Met Leu Asp Ala Leu Val Leu Asp Arg Val Asp Phe Val Lys Leu Leu Ile Glu Asn Gly Val Ser Met His Arg Phe Leu Thr Ile Ser Arg Leu Glu Glu Leu Tyr Asn Thr Arg His Gly Pro Ser Asn Thr Leu Tyr His Leu Val Arg Asp Val Lys Lys Gly Asn Leu Pro Pro Asp Tyr Arg Ile Ser Leu Ile Asp Ile Gly Leu Val Ile Glu Tyr Leu Met Gly Gly Ala Tyr Arg Cys Asn Tyr Thr Arg Lys Arg Phe Arg Thr Leu Tyr His Asn Leu Phe Gly Pro Lys Arg Pro Lys Ala Leu Lys Leu Leu Gly Met Glu Asp Asp Ile Pro Leu Arg Arg Gly Arg Lys Thr Thr Lys Lys Arg Glu Glu Glu Val Asp Ile Asp Leu Asp Asp Pro Glu Ile Asn His Phe Pro Phe Pro Phe His Glu Leu Met Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala Leu Phe Phe Trp Gln His Gly Glu Glu Ala Met Ala Lys Ala Leu Val Ala Cys Lys Leu Cys Lys Ala Met Ala His Glu Ala Ser Glu Asn Asp Met Val Asp Asp Ile Ser Gln Glu Leu Asn His Asn Ser Arg Asp Phe Gly Gln Leu Ala Val Glu Leu Leu Asp Gln Ser Tyr Lys Gln Asp Glu Gln Leu Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ala Thr Cys Leu Gln Leu Ala Val Ala Ala Lys His Arg Asp Phe Ile Ala His Thr Cys Ser Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg Leu Arg Met Arg Lys Asn Ser Gly Leu Lys Val Ile Leu Gly Ile Leu Leu Pro Pro Ser Ile Leu Ser Leu Glu Phe Lys Asn Lys Asp Asp Met Pro Tyr Met Ser Gln Ala Gln Glu Ile His Leu Gln Glu Lys Glu Ala Glu Glu Pro Glu Lys Pro Thr Lys Glu Lys Glu Glu Glu Asp Met Glu Leu Thr Ala Met Leu Gly Arg Asn Asn Gly Glu Ser Ser Arg Lys Lys Asp Glu Glu Glu Val Gln Ser Lys His Arg Leu Ile Pro Leu Gly Arg Lys Ile Tyr Glu Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Leu Ala Tyr Ile Gly Tyr Leu Met Leu Phe Asn Tyr Ile Val Leu Val Lys Met Glu Arg Trp Pro Ser Thr Gln Glu Trp Ile Val Ile Ser Tyr Ile Phe Thr Leu Val Pro Ala Gly Cys Leu His Phe Gly Leu Pro Ile His Gly Ala Phe Ser Ser <210> 3 <211> 2472 <212> DNA
<213> homo Sapiens <400>

atgtatgtgcgagtatcttttgatacaaaacctgatctcctcttacacctgatgaccaag 60 gaatggcagttggagcttcccaagcttctcatctctgtccatgggggcctgcagaacttt 120 gaactccagccaaaactcaagcaagtctttgggaaagggctcatcaaagcagcaatgaca 180 actggagcgtggatattcactggaggggttaacacaggtgttattcgtcatgttggcgat 240 gccttgaaggatcatgcctctaagtctcgaggaaagatatgcaccataggtattgccccc 300 tggggaattgtggaaaaccaggaggacctcattggaagagatgttgtccggccataccag 360 accatgtccaatcccatgagcaagctcactgttctcaacagcatgcattcccacttcatt 420 ctggctgacaacgggaccactggaaaatatggagcagaggtgaaacttcgaagacaactg 480 gaaaagcatatttcactccagaagataaacacaagatgcctgccgtttttctctcttgac 540 tcccgcttgttttattcattttggggtagttgccagttagactcagttggaatcggtcaa 600 ggtgttcctgtggtggcactcatagtggaaggaggacccaatgtgatctcgattgttttg 660 gagtaccttcgagacacccctcccgtgccagtggttgtctgtgatgggagtggacgggca 720 tcggacatcctggcctttgggcataaatactcagaagaaggcggactgataaatgaatct 780 ttgagggaccagctgttggtgactatacagaagactttcacatacactcgaacccaagct 840 cagcatctgttcatcatcctcatggagtgcatgaagaagaaggaattgattacggtattt 900 cggatgggatcagaaggacaccaggacattgatttggctatcctgacagctttactcaaa 960 ggagccaatgcctcggccccagaccaactgagcttagctttagcctggaacagagtcgac 1020 atcgctcgcagccagatctttatttacgggcaacagtggccggtgggatctctggagcaa 1080 gccatgttggatgccttagttctggacagagtggattttgtgaaattactcatagagaat 1140 ggagtaagcatgcaccgttttctcaccatctccagactagaggaattgtacaatacgaga 1200 catgggccctcaaatacattgtaccacttggtcagggatgtcaaaaaggggaacctgccc 1260 ccagactacagaatcagcctgattgacatcggcctggtgatcgagtacctgatgggcggg 1320 gcttatcgctgcaactacacgcgcaagcgcttccggaccctctaccacaacctcttcggc 1380 cccaagaggcccaaagccttgaaactgctgggaatggaggatgatattcccttgaggcga 1440 ggaagaaagacaaccaagaaacgtgaagaagaggtggacattgacttggatgatcctgag 1500 atcaaccacttccccttccctttccatgagctcatggtgtgggctgttctcatgaagcgg 1560 cagaagatggccctgttcttctggcagcacggtgaggaggccatggccaaggccctggtg 1620 gcctgcaagctctgcaaagccatggctcatgaggcctctgagaacgacatggttgacgac 1680 atttcccaggagctgaatcacaattccagagactttggccagctggctgtggagctcctg 1740 gaccagtcctacaagcaggacgaacagctggccatgaaactgctgacgtatgagctgaag 1800 aactggagcaacgccacgtgcctgcagcttgccgtggctgccaaacaccgcgacttcatc 1860 gcgcacacgtgcagccagatgctgctcaccgacatgtggatgggccggctccgcatgcgc 1920 aagaactcaggcctcaaggtaattctgggaattctacttcctccttcaattctcagcttg 1980 gagttcaagaacaaagacgacatgccctatatgtctcaggcccaggaaatccacctccaa 2040 gagaaggaggcagaagaaccagagaagcccacaaaggaaaaagaggaagaggacatggag 2100 ctcacagcaatgttgggacgaaacaacggggagtcctccaggaagaaggatgaagaggaa 2160 gttcagagcaagcaccggttaatccccctcggcagaaaaatctatgaattctacaatgca 2220 cccatcgtgaagttctggttctacacactggcgtatatcggatacctgatgctcttcaac 2280 tatatcgtgttagtgaagatggaacgctggccgtccacccaggaatggatcgtaatctcc 2340 tatattttcaccctgggaatagaaaagatgagagaggtaacggcttttataaaagaaaac 2400 gtaagagaaagacagtggttaagttctatctgtggatggaggggacaggaagatgcctgg 2460 gatgcaaattas <210> 4 <211> 823 <212> PRT
<213> homo sapiens <400> 4 Met Tyr Val Arg Val Ser Phe Asp Thr Lys Pro Asp Leu Leu Leu His Leu Met Thr Lys Glu Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser Val His Gly Gly Leu Gln Asn Phe Glu Leu Gln Pro Lys Leu Lys Gln Val Phe Gly Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp Ile Phe Thr Gly Gly Val Asn Thr Gly Val Ile Arg His Val Gly Asp Ala Leu Lys Asp His Ala Ser Lys Ser Arg Gly Lys Ile Cys Thr Ile Gly Ile Ala Pro Trp Gly Ile Val Glu Asn Gln Glu Asp Leu Ile Gly Arg Asp Val Val Arg Pro Tyr Gln Thr Met Ser Asn Pro Met Ser Lys Leu Thr Val Leu Asn Ser Met His Ser His Phe Ile Leu Ala Asp Asn Gly Thr Thr Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Gln Leu Glu Lys His Ile Ser Leu Gln Lys Ile Asn Thr Arg Cys Leu Pro Phe Phe Ser Leu Asp Ser Arg Leu Phe Tyr Ser Phe Trp Gly Ser Cys Gln Leu Asp Ser Val Gly Ile Gly Gln Gly Val Pro Val Val Ala Leu Ile Val Glu Gly Gly Pro Asn Val Ile Ser Ile Val Leu Glu Tyr Leu Arg Asp Thr Pro Pro Val Pro Val Val Val Cys Asp Gly Ser Gly Arg Ala Ser Asp Ile Leu Ala Phe Gly His Lys Tyr Ser Glu Glu Gly Gly Leu Ile Asn Glu Ser Leu Arg Asp Gln Leu Leu Val Thr Ile Gln Lys Thr Phe Thr Tyr Thr Arg Thr Gln Ala Gln His Leu Phe Ile Ile Leu Met Glu Cys Met Lys Lys Lys Glu Leu Ile Thr Val Phe Arg Met Gly Ser Glu Gly His Gln Asp Ile Asp Leu Ala Ile Leu Thr Ala Leu Leu Lys Gly Ala Asn Ala Ser Ala Pro Asp Gln Leu Ser Leu Ala Leu Ala Trp Asn Arg Val Asp Ile Ala Arg Ser Gln Ile Phe Ile Tyr Gly Gln Gln Trp Pro Val Gly Ser Leu Glu Gln Ala Met Leu Asp Ala Leu Val Leu Asp Arg Val Asp Phe Val Lys Leu Leu Ile Glu Asn Gly Val Ser Met His Arg Phe Leu Thr Ile Ser Arg Leu Glu Glu Leu Tyr Asn Thr Arg His Gly Pro Ser Asn Thr Leu Tyr His Leu Val Arg Asp Val Lys Lys Gly Asn Leu Pro Pro Asp Tyr Arg Ile Ser Leu Ile Asp Ile Gly Leu Val Ile Glu Tyr Leu Met Gly Gly Ala Tyr Arg Cys Asn Tyr Thr Arg Lys Arg Phe Arg Thr Leu Tyr His Asn Leu Phe Gly Pro Lys Arg Pro Lys Ala Leu Lys Leu Leu Gly Met Glu Asp Asp Ile Pro Leu Arg Arg Gly Arg Lys Thr Thr Lys Lys Arg Glu Glu Glu Val Asp Ile Asp Leu Asp Asp Pro Glu Ile Asn His Phe Pro Phe Pro Phe His Glu Leu Met Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala Leu Phe Phe Trp Gln His Gly Glu Glu Ala Met Ala Lys Ala Leu Val Ala Cys Lys Leu Cys Lys Ala Met Ala His Glu Ala Ser Glu Asn Asp Met Val Asp Asp Ile Ser Gln Glu Leu Asn His Asn Ser Arg Asp Phe Gly Gln Leu Ala Val Glu Leu Leu Asp Gln Ser Tyr Lys Gln Asp Glu Gln Leu Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ala Thr Cys Leu Gln Leu Ala Val Ala Ala Lys His Arg Asp Phe Ile Ala His Thr Cys Ser Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg Leu Arg Met Arg Lys Asn Ser Gly Leu Lys Val Ile Leu Gly Ile Leu Leu Pro Pro Ser Ile Leu Ser Leu Glu Phe Lys Asn Lys Asp Asp Met Pro Tyr Met Ser Gln Ala Gln Glu Ile His Leu Gln Glu Lys Glu Ala Glu Glu Pro Glu Lys Pro Thr Lys Glu Lys Glu Glu Glu Asp Met Glu Leu Thr Ala Met Leu Gly Arg Asn Asn Gly Glu Ser Ser Arg Lys Lys Asp Glu Glu Glu Val Gln Ser Lys His Arg Leu Ile Pro Leu Gly Arg Lys Ile Tyr Glu Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Leu Ala Tyr Ile Gly Tyr Leu Met Leu Phe Asn Tyr Ile Val Leu Val Lys Met Glu Arg Trp Pro Ser Thr Gln Glu Trp Ile Val Ile Ser Tyr Ile Phe Thr Leu Gly Ile Glu Lys Met Arg Glu Val Thr Ala Phe Ile Lys Glu Asn Val Arg Glu Arg Gln Trp Leu Ser Ser Ile Cys Gly Trp Arg Gly Gln Glu Asp Ala Trp Asp Ala Asn <210> 5 <211> 2847 <212> DNA
<213> homo sapiens <400>

atgtatgtgcgagtatcttttgatacaaaacctgatctcctcttacacctgatgaccaag 60 gaatggcagttggagcttcccaagcttctcatctctgtccatgggggcctgcagaacttt 120 gaactccagccaaaactcaagcaagtctttgggaaagggctcatcaaagcagcaatgaca 180 actggagcgtggatattcactggaggggttaacacaggtgttattcgtcatgttggcgat 240 gccttgaaggatcatgcctctaagtctcgaggaaagatatgcaccataggtattgccccc 300 tggggaattgtggaaaaccaggaggacctcattggaagagatgttgtccggccataccag 360 accatgtccaatcccatgagcaagctcactgttctcaacagcatgcattcccacttcatt 420 ctggctgacaacgggaccactggaaaatatggagcagaggtgaaacttcgaagacaactg 480 gaaaagcatatttcactccagaagataaacacaagatgcctgccgtttttctctcttgac 540 tcccgcttgttttattcattttggggtagttgccagttagactcagttggaatcggtcaa 600 ggtgttcctgtggtggcactcatagtggaaggaggacccaatgtgatctcgattgttttg 660 gagtaccttcgagacacccctcccgtgccagtggttgtctgtgatgggagtggacgggca 720 tcggacatcctggcctttgggcataaatactcagaagaaggcggactgataaatgaatct 780 ttgagggaccagctgttggtgactatacagaagactttcacatacactcgaacccaagct 840 cagcatctgttcatcatcctcatggagtgcatgaagaagaaggaattgattacggtattt 900 cggatgggatcagaaggacaccaggacattgatttggctatcctgacagctttactcaaa 960 ggagccaatgcctcggccccagaccaactgagcttagctttagcctggaacagagtcgac 1020 atcgctcgcagccagatctttatttacgggcaacagtggccggtgggatctctggagcaa 1080 gccatgttggatgccttagttctggacagagtggattttgtgaaattactcatagagaat 1140 ggagtaagcatgcaccgttttctcaccatctccagactagaggaattgtacaatacgaga 1200 catgggccctcaaatacattgtaccacttggtcagggatgtcaaaaaggggaacctgccc 1260 ccagactacagaatcagcctgattgacatcggcctggtgatcgagtacctgatgggcggg 1320 gcttatcgctgcaactacacgcgcaagcgcttccggaccctctaccacaacctcttcggc 1380 cccaagaggcccaaagccttgaaactgctgggaatggaggatgatattcccttgaggcga 1440 ggaagaaagacaaccaagaaacgtgaagaagaggtggacattgacttggatgatcctgag 1500 atcaaccacttccccttccctttccatgagctcatggtgtgggctgttctcatgaagcgg 1560 cagaagatggccctgttcttctggcagcacggtgaggaggccatggccaaggccctggtg 1620 gcctgcaagctctgcaaagccatggctcatgaggcctctgagaacgacatggttgacgac 1680 atttcccaggagctgaatcacaattccagagactttggccagctggctgtggagctcctg 1740 gaccagtcctacaagcaggacgaacagctggccatgaaactgctgacgtatgagctgaag 1800 aactggagcaacgccacgtgcctgcagcttgccgtggctgccaaacaccgcgacttcatc 1860 gcgcacacgtgcagccagatgctgctcaccgacatgtggatgggccggctccgcatgcgc 1920 aagaactcaggcctcaaggtaattctgggaattctacttcctccttcaattctcagcttg 1980 gagttcaagaacaaagacgacatgccctatatgtctcaggcccaggaaatccacctccaa 2040 gagaaggaggcagaagaaccagagaagcccacaaaggaaaaagaggaagaggacatggag 2100 ctcacagcaatgttgggacgaaacaacggggagtcctccaggaagaaggatgaagaggaa 2160 gttcagagcaagcaccggttaatccccctcggcagaaaaatctatgaattctacaatgca 2220 cccatcgtgaagttctggttctacacactggcgtatatcggatacctgatgctcttcaac 2280 tatatcgtgttagtgaagatggaacgctggccgtccacccaggaatggatcgtaatctcc2340 tatattttcaccctgggaatagaaaagatgagagagattctgatgtcagagccagggaag2400 ttgctacagaaagtgaaggtatggctgcaggagtactggaatgtcacggacctcatcgcc2460 atccttctgttttctgtcggaatgatccttcgtctccaagaccagcccttcaggagtgac2520 gggagggtcatctactgcgtgaacatcatttactggtatatccgtctcctagacatcttc2580 ggcgtgaacaagtatttgggcccgtatgtaatgatgattggaaaaatgatgatagacatg2640 atgtactttgtcatcattatgctggtggttctgatgagctttggggtcgccaggcaagcc2700 atcctttttcccaatgaggagccatcatggaaactggccaagaacatcttctacatgccc2760 tattggatgatttatggggaagtgtttgcggaccagatagaccgtaagcaagtttatgat2820 tctcatacaccaaagtcaggtatttaa 2847 <210> 6 <211> 948 <212> PRT
<213> homo Sapiens <400> 6 Met Tyr Val Arg Val Ser Phe Asp Thr Lys Pro Asp Leu Leu Leu His Leu Met Thr Lys Glu Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser Val His Gly Gly Leu Gln Asn Phe Glu Leu Gln Pro Lys Leu Lys Gln Val Phe Gly Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp Ile Phe Thr Gly Gly Val Asn Thr Gly Val Ile Arg His Val Gly Asp Ala Leu Lys Asp His Ala Ser Lys Ser Arg Gly Lys Ile Cys Thr Ile Gly Ile Ala Pro Trp Gly Ile Val Glu Asn Gln Glu Asp Leu Ile Gly Arg Asp Val Val Arg Pro Tyr Gln Thr Met Ser Asn Pro Met Ser Lys Leu Thr Val Leu Asn Ser Met His Ser His Phe Ile Leu Ala Asp Asn Gly Thr Thr Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Gln Leu Glu Lys His Ile Ser Leu Gln Lys Ile Asn Thr Arg Cys Leu Pro Phe Phe Ser Leu Asp Ser Arg Leu Phe Tyr Ser Phe Trp Gly Ser Cys Gln Leu Asp Ser Val Gly Ile Gly Gln Gly Val Pro Val Val Ala Leu Ile Val Glu Gly Gly Pro Asn Val Ile Ser Ile Val Leu Glu Tyr Leu Arg 210 215 ' 220 Asp Thr Pro Pro Val Pro Val Val Val Cys Asp Gly Ser Gly Arg Ala Ser Asp Ile Leu Ala Phe Gly His Lys Tyr Ser Glu Glu Gly Gly Leu Ile Asn Glu Ser Leu Arg Asp Gln Leu Leu Val Thr Ile Gln Lys Thr Phe Thr Tyr Thr Arg Thr Gln Ala Gln His Leu Phe Ile Ile Leu Met Glu Cys Met Lys Lys Lys Glu Leu Ile Thr Val Phe Arg Met Gly Ser Glu Gly His Gln Asp Ile Asp Leu Ala Ile Leu Thr Ala Leu Leu Lys Gly Ala Asn Ala Ser Ala Pro Asp Gln Leu Ser Leu Ala Leu Ala Trp Asn Arg Val Asp Ile Ala Arg Ser Gln Ile Phe Ile Tyr Gly Gln Gln Trp Pro Val Gly Ser Leu Glu Gln Ala Met Leu Asp Ala Leu Val Leu Asp Arg Val Asp Phe Val Lys Leu Leu Ile Glu Asn Gly Val Ser Met His Arg Phe Leu Thr Ile Ser Arg Leu Glu Glu Leu Tyr Asn Thr Arg His Gly Pro Ser Asn Thr Leu Tyr His Leu Val Arg Asp Val Lys Lys Gly Asn Leu Pro Pro Asp Tyr Arg Ile Ser Leu Ile Asp Ile Gly Leu Val Ile Glu Tyr Leu Met Gly Gly Ala Tyr Arg Cys Asn Tyr Thr Arg Lys Arg Phe Arg Thr Leu Tyr His Asn Leu Phe Gly Pro Lys Arg Pro Lys Ala Leu Lys Leu Leu Gly Met Glu Asp Asp Ile Pro Leu Arg Arg Gly Arg Lys Thr Thr Lys Lys Arg Glu Glu Glu Val Asp Ile Asp Leu Asp Asp Pro Glu Ile Asn His Phe Pro Phe Pro Phe His Glu Leu Met Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala Leu Phe Phe Trp Gln His Gly Glu Glu Ala Met Ala Lys Ala Leu Val Ala Cys Lys Leu Cys Lys Ala Met Ala His Glu Ala Ser Glu Asn Asp Met Val Asp Asp Ile Ser Gln Glu Leu Asn His Asn Ser Arg Asp Phe Gly Gln Leu Ala Val Glu Leu Leu Asp Gln Ser Tyr Lys Gln Asp Glu Gln Leu Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ala Thr Cys Leu Gln Leu Ala Val Ala Ala Lys His Arg Asp Phe Ile Ala His Thr Cys Ser Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg Leu Arg Met Arg Lys Asn Ser Gly Leu Lys Val Ile Leu Gly Ile Leu Leu Pro Pro Ser Ile Leu Ser Leu Glu Phe Lys Asn Lys Asp Asp Met Pro Tyr Met Ser Gln Ala Gln Glu Ile His Leu Gln Glu Lys Glu Ala Glu Glu Pro Glu Lys Pro Thr Lys Glu Lys Glu Glu Glu Asp Met Glu Leu Thr Ala Met Leu Gly Arg Asn Asn Gly Glu Ser Ser Arg Lys Lys Asp Glu Glu Glu Val Gln Ser Lys His Arg Leu Ile Pro Leu Gly Arg Lys Ile Tyr Glu Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Leu Ala Tyr Ile Gly Tyr Leu Met Leu Phe Asn Tyr Ile Val Leu Val Lys Met Glu Arg Trp Pro Ser Thr Gln Glu Trp Ile Val Ile Ser Tyr Ile Phe Thr Leu Gly Ile Glu Lys Met Arg Glu Ile Leu Met Ser Glu Pro Gly Lys Leu Leu Gln Lys Val Lys Val Trp Leu Gln Glu Tyr Trp Asn Val Thr Asp Leu Ile Ala Ile Leu Leu Phe Ser Val Gly Met Ile Leu Arg Leu Gln Asp Gln Pro Phe Arg Ser Asp Gly Arg Val Ile Tyr Cys Val Asn Ile Ile Tyr Trp Tyr Ile Arg Leu Leu Asp Ile Phe Gly Val Asn Lys Tyr Leu Gly Pro Tyr Val Met Met Ile Gly Lys Met Met Ile Asp Met Met Tyr Phe Val Ile Ile Met Leu Val Val Leu Met Ser Phe Gly Val Ala Arg Gln Ala Ile Leu Phe Pro Asn Glu Glu Pro Ser Trp Lys Leu Ala Lys Asn Ile Phe Tyr Met Pro Tyr Trp Met Ile Tyr Gly Glu Val Phe Ala Asp Gln Ile Asp Arg Lys Gln Val Tyr Asp Ser His Thr Pro Lys Ser Gly Ile <210> 7 <211> 3405 <212> DNA
<213> homo sapiens <400>

atgtatgtgcgagtatcttttgatacaaaacctgatctcctcttacacctgatgaccaag60 gaatggcagttggagcttcccaagcttctcatctctgtccatgggggcctgcagaacttt120 gaactccagccaaaactcaagcaagtctttgggaaagggctcatcaaagcagcaatgaca180 actggagcgtggatattcactggaggggttaacacaggtgttattcgtcatgttggcgat240 gccttgaaggatcatgcctctaagtctcgaggaaagatatgcaccataggtattgccccc300 tggggaattgtggaaaaccaggaggacctcattggaagagatgttgtccggccataccag360 accatgtccaatcccatgagcaagctcactgttctcaacagcatgcattcccacttcatt420 ctggctgacaacgggaccactggaaaatatggagcagaggtgaaacttcgaagacaactg480 gaaaagcatatttcactccagaagataaacacaagatgcctgccgtttttctctcttgac540 tcccgcttgttttattcattttggggtagttgccagttagactcagttggaatcggtcaa600 ggtgttcctgtggtggcactcatagtggaaggaggacccaatgtgatctcgattgttttg660 gagtaccttcgagacacccctcccgtgccagtggttgtctgtgatgggagtggacgggca720 tcggacatcctggcctttgggcataaatactcagaagaaggcggactgataaatgaatct780 ttgagggaccagctgttggtgactatacagaagactttcacatacactcgaacccaagct840 cagcatctgttcatcatcctcatggagtgcatgaagaagaaggaattgattacggtattt900 cggatgggatcagaaggacaccaggacattgatttggctatcctgacagctttactcaaa960 ggagccaatgcctcggccccagaccaactgagcttagctttagcctggaacagagtcgac1020 atcgctcgcagccagatctttatttacgggcaacagtggccggtgggatctctggagcaa1080 gccatgttggatgccttagttctggacagagtggattttgtgaaattactcatagagaat1140 ggagtaagcatgcaccgttttctcaccatctccagactagaggaattgtacaatacgaga1200 catgggccctcaaatacattgtaccacttggtcagggatgtcaaaaaggggaacctgccc1260 ccagactacagaatcagcctgattgacatcggcctggtgatcgagtacctgatgggcggg1320 gcttatcgctgcaactacacgcgcaagcgcttccggaccctctaccacaacctcttcggc1380 cccaagaggcccaaagccttgaaactgctgggaatggaggatgatattcccttgaggcga1440 ggaagaaagacaaccaagaaacgtgaagaagaggtggacattgacttggatgatcctgag1500 atcaaccacttccccttccctttccatgagctcatggtgtgggctgttctcatgaagcgg1560 cagaagatggccctgttcttctggcagcacggtgaggaggccatggccaaggccctggtg1620 gcctgcaagctctgcaaagccatggctcatgaggcctctgagaacgacatggttgacgac1680 atttcccaggagctgaatcacaattccagagactttggccagctggctgtggagctcctg1740 gaccagtcctacaagcaggacgaacagctggccatgaaactgctgacgtatgagctgaag1800 aactggagcaacgccacgtgcctgcagcttgccgtggctgccaaacaccgcgacttcatc1860 gcgcacacgtgcagccagatgctgctcaccgacatgtggatgggccggctccgcatgcgc1920 aagaactcaggcctcaaggtaattctgggaattctacttcctccttcaattctcagcttg1980 gagttcaagaacaaagacgacatgccctatatgtctcaggcccaggaaatccacctccaa2040 gagaaggaggcagaagaaccagagaagcccacaaaggaaaaagaggaagaggacatggag2100 ctcacagcaatgttgggacgaaacaacggggagtcctccaggaagaaggatgaagaggaa2160 gttcagagcaagcaccggttaatccccctcggcagaaaaatctatgaattctacaatgca2220 cccatcgtgaagttctggttctacacactggcgtatatcggatacctgatgctcttcaac2280 tatatcgtgttagtgaagatggaacgctggccgtccacccaggaatggatcgtaatctcc2340 tatattttcaccctgggaatagaaaagatgagagagattctgatgtcagagccagggaag2400 ttgctacagaaagtgaaggtatggctgcaggagtactggaatgtcacggacctcatcgcc2460 atccttctgttttctgtcggaatgatccttcgtctccaagaccagcccttcaggagtgac2520 gggagggtcatctactgcgtgaacatcatttactggtatatccgtctcctagacatcttc2580 ggcgtgaacaagtatttgggcccgtatgtaatgatgattggaaaaatgatgatagacatg2640 atgtactttgtcatcattatgctggtggttctgatgagctttggggtcgccaggcaagcc2700 atcctttttcccaatgaggagccatcatggaaactggccaagaacatcttctacatgccc 2760 tattggatgatttatggggaagtgtttgcggaccagatagaccctccctgtggacagaat 2820 gagacccgagaggatggtaaaataatccagctgcctccctgcaagacaggagcttggatc 2880 gtgccggccatcatggcctgctacctcttagtggcaaacatcttgctggtcaacctcctc 2940 attgctgtctttaacaatacattttttgaagtaaaatcgatatccaaccaagtctggaag 3000 tttcagaggtatcagctcatcatgactttccatgaaaggccagttctgcccccaccactg 3060 atcatcttcagccacatgaccatgatattccagcacctgtgctgccgatggaggaaacac 3120 gagagcgacccggatgaaagggactacggcctgaaactcttcataaccgatgatgagctc 3180 aagaaagtacatgactttgaagagcaatgcatagaagaatacttcagagaaaaggatgat 3240 cggttcaactcatctaatgatgagaggatacgggtgacttcagaaaggtgtgttctgtgg 3300 acacctgcctcctgcagatgtgttgtgccaaggcatgctttatccatcgaatttattcac 3360 acggtcacaaaacagagatcttttgtgtttgtttttattgtctga 3405 <210> 8 <211> 1134 <212> PRT
<213> homo Sapiens <400> 8 Met Tyr Val Arg Val Ser Phe Asp Thr Lys Pro Asp Leu Leu Leu His Leu Met Thr Lys Glu Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser Val His Gly Gly Leu Gln Asn Phe Glu Leu Gln Pro Lys Leu Lys Gln Val Phe Gly Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp Ile Phe Thr Gly Gly Val Asn Thr Gly Val Ile Arg His Val Gly Asp Ala Leu Lys Asp His Ala Ser Lys Ser Arg Gly Lys Ile Cys Thr Ile Gly Ile Ala Pro Trp Gly Ile Val Glu Asn Gln Glu Asp Leu Ile Gly Arg Asp Val Val Arg Pro Tyr Gln Thr Met Ser Asn Pro Met Ser Lys Leu Thr Val Leu Asn Ser Met His Ser His Phe Ile Leu Ala Asp Asn Gly Thr Thr Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Gln Leu Glu Lys His Ile Ser Leu Gln Lys Ile Asn Thr Arg Cys Leu Pro Phe Phe Ser Leu Asp Ser Arg Leu Phe Tyr Ser Phe Trp Gly Ser Cys Gln Leu Asp Ser Val Gly Ile Gly Gln Gly Val Pro Val Val Ala Leu Ile Val Glu Gly Gly Pro Asn Val Ile Ser Ile Val Leu Glu Tyr Leu Arg Asp Thr Pro Pro Val Pro Val Val Val Cys Asp Gly Ser Gly Arg Ala Ser Asp Ile Leu Ala Phe Gly His Lys Tyr Ser Glu Glu Gly Gly Leu Ile Asn Glu Ser Leu Arg Asp Gln Leu Leu Val Thr Ile Gln Lys Thr Phe Thr Tyr Thr Arg Thr Gln Ala Gln His Leu Phe Ile Ile Leu Met Glu Cys Met Lys Lys Lys Glu Leu Ile Thr Val Phe Arg Met Gly Ser Glu Gly His Gln Asp Ile Asp Leu Ala Ile Leu Thr Ala Leu Leu Lys Gly Ala Asn Ala Ser Ala Pro Asp Gln Leu Ser Leu Ala Leu Ala Trp Asn Arg Val Asp Ile Ala Arg Ser Gln Ile Phe Ile Tyr Gly Gln Gln Trp Pro Val Gly Ser Leu Glu Gln Ala Met Leu Asp Ala Leu Val Leu Asp Arg Val Asp Phe Val Lys Leu Leu Ile Glu Asn Gly Val Ser Met His Arg Phe Leu Thr Ile Ser Arg Leu Glu Glu Leu Tyr Asn Thr Arg His Gly Pro Ser Asn Thr Leu Tyr His Leu Val Arg Asp Val Lys Lys Gly Asn Leu Pro Pro Asp Tyr Arg Ile Ser Leu Ile Asp Ile Gly Leu Val Ile Glu Tyr Leu Met Gly Gly Ala Tyr Arg Cys Asn Tyr Thr Arg Lys Arg Phe Arg Thr Leu Tyr His Asn Leu Phe Gly Pro Lys Arg Pro Lys Ala Leu Lys Leu Leu Gly Met Glu Asp Asp Ile Pro Leu Arg Arg Gly Arg Lys Thr Thr Lys Lys Arg Glu Glu Glu Val Asp Ile Asp Leu Asp Asp Pro Glu Ile Asn His Phe Pro Phe Pro Phe His Glu Leu Met Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala Leu Phe Phe Trp Gln His Gly Glu Glu Ala Met Ala Lys Ala Leu Val Ala Cys Lys Leu Cys Lys Ala Met Ala His Glu Ala Ser Glu Asn Asp Met Val Asp Asp Ile Ser Gln Glu Leu Asn His Asn Ser Arg Asp Phe Gly Gln Leu Ala Val Glu Leu Leu Asp Gln Ser Tyr Lys Gln Asp Glu Gln Leu Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ala Thr Cys Leu Gln Leu Ala Val Ala Ala Lys His Arg Asp Phe Ile Ala His Thr Cys Ser Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg Leu Arg Met Arg Lys Asn Ser Gly Leu Lys Val Ile Leu Gly Ile Leu Leu Pro Pro Ser Ile Leu Ser Leu Glu Phe Lys Asn Lys Asp Asp Met Pro Tyr Met Ser Gln Ala Gln Glu Ile His Leu Gln Glu Lys Glu Ala Glu Glu Pro Glu Lys Pro Thr Lys Glu Lys Glu Glu Glu Asp Met Glu Leu Thr Ala Met Leu Gly Arg Asn Asn Gly Glu Ser Ser Arg Lys Lys Asp Glu Glu Glu Val Gln Ser Lys His Arg Leu Ile Pro Leu Gly Arg Lys Ile Tyr Glu Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Leu Ala Tyr Ile Gly Tyr Leu Met Leu Phe Asn Tyr Ile Val Leu Val Lys Met Glu Arg Trp Pro Ser Thr Gln Glu Trp Ile Val Ile Ser Tyr Ile Phe Thr Leu Gly Ile Glu Lys Met Arg Glu Ile Leu Met Ser Glu Pro Gly Lys Leu Leu Gln Lys Val Lys Val Trp Leu Gln Glu Tyr Trp Asn Val Thr Asp Leu Ile Ala Ile Leu Leu Phe Ser Val Gly Met Ile Leu Arg Leu Gln Asp Gln Pro Phe Arg Ser Asp Gly Arg Val Ile Tyr Cys Val Asn Ile Ile Tyr Trp Tyr Ile Arg Leu Leu Asp Ile Phe Gly Val Asn Lys Tyr Leu Gly Pro Tyr Val Met Met Ile Gly Lys Met Met Ile Asp Met Met Tyr Phe Val Ile Ile Met Leu Val Val Leu Met Ser Phe Gly Val Ala Arg Gln Ala Ile Leu Phe Pro Asn Glu Glu Pro Ser Trp Lys Leu Ala Lys Asn Ile Phe Tyr Met Pro Tyr Trp Met Ile Tyr Gly Glu Val Phe Ala Asp Gln Ile Asp Pro Pro Cys Gly Gln Asn Glu Thr Arg Glu Asp Gly Lys Ile Ile Gln Leu Pro Pro Cys Lys Thr Gly Ala Trp Ile Val Pro Ala Ile Met Ala Cys Tyr Leu Leu Val Ala Asn Ile Leu Leu Val Asn Leu Leu Ile Ala Val Phe Asn Asn Thr Phe Phe Glu Val Lys Ser Ile Ser Asn Gln Val Trp Lys Phe Gln Arg Tyr Gln Leu Ile Met Thr Phe His Glu Arg Pro Val Leu Pro Pro Pro Leu Ile Ile Phe Ser His Met Thr Met Ile Phe Gln His Leu Cys Cys Arg Trp Arg Lys His Glu Ser Asp Pro Asp Glu Arg Asp Tyr Gly Leu Lys Leu Phe Ile Thr Asp Asp Glu Leu Lys Lys Val His Asp Phe Glu Glu Gln Cys Ile Glu Glu Tyr Phe Arg Glu Lys Asp Asp Arg Phe Asn Ser Ser Asn Asp Glu Arg Ile Arg Val Thr Ser Glu Arg Cys Val Leu Trp Thr Pro Ala Ser Cys Arg Cys Val Val Pro Arg His Ala Leu Ser Ile Glu Phe Ile His Thr Val Thr Lys Gln Arg Ser Phe Val Phe Val Phe Ile Val <210> 9 <211> 3594 <212> DNA
<213> homo sapiens <400>

atgtatgtgcgagtatcttttgatacaaaacctgatctcctcttacacctgatgaccaag 60 gaatggcagttggagcttcccaagcttctcatctctgtccatgggggcctgcagaacttt 120 gaactccagccaaaactcaagcaagtctttgggaaagggctcatcaaagcagcaatgaca 180 actggagcgtggatattcactggaggggttaacacaggtgttattcgtcatgttggcgat 240 gccttgaaggatcatgcctctaagtctcgaggaaagatatgcaccataggtattgccccc 300 tggggaattgtggaaaaccaggaggacctcattggaagagatgttgtccggccataccag 360 accatgtccaatcccatgagcaagctcactgttctcaacagcatgcattcccacttcatt 420 ctggctgacaacgggaccactggaaaatatggagcagaggtgaaacttcgaagacaactg 480 gaaaagcatatttcactccagaagataaacacaagatgcctgccgtttttctctcttgac 540 tcccgcttgttttattcattttggggtagttgccagttagactcagttggaatcggtcaa 600 ggtgttcctgtggtggcactcatagtggaaggaggacccaatgtgatctcgattgttttg 660 gagtaccttcgagacacccctcccgtgccagtggttgtctgtgatgggagtggacgggca 720 tcggacatcctggcctttgggcataaatactcagaagaaggcggactgataaatgaatct 780 ttgagggaccagctgttggtgactatacagaagactttcacatacactcgaacccaagct 840 cagcatctgttcatcatcctcatggagtgcatgaagaagaaggaattgattacggtattt 900 cggatgggatcagaaggacaccaggacattgatttggctatcctgacagctttactcaaa 960 ggagccaatgcctcggccccagaccaactgagcttagctttagcctggaacagagtcgac 1020 atcgctcgcagccagatctttatttacgggcaacagtggccggtgggatctctggagcaa 1080 gccatgttggatgccttagttctggacagagtggattttgtgaaattactcatagagaat 1140 ggagtaagcatgcaccgttttctcaccatctccagactagaggaattgtacaatacgaga 1200 catgggccctcaaatacattgtaccacttggtcagggatgtcaaaaaggggaacctgccc 1260 ccagactacagaatcagcctgattgacatcggcctggtgatcgagtacctgatgggcggg1320 gcttatcgctgcaactacacgcgcaagcgcttccggaccctctaccacaacctcttcggc1380 cccaagaggcccaaagccttgaaactgctgggaatggaggatgatattcccttgaggcga1440 ggaagaaagacaaccaagaaacgtgaagaagaggtggacattgacttggatgatcctgag1500 atcaaccacttccccttccctttccatgagctcatggtgtgggctgttctcatgaagcgg1560 cagaagatggccctgttcttctggcagcacggtgaggaggccatggccaaggccctggtg1620 gcctgcaagctctgcaaagccatggctcatgaggcctctgagaacgacatggttgacgac1680 atttcccaggagctgaatcacaattccagagactttggccagctggctgtggagctcctg1740 gaccagtcctacaagcaggacgaacagctggccatgaaactgctgacgtatgagctgaag1800 aactggagcaacgccacgtgcctgcagcttgccgtggctgccaaacaccgcgacttcatc1860 gcgcacacgtgcagccagatgctgctcaccgacatgtggatgggccggctccgcatgcgc1920 aagaactcaggcctcaaggtaattctgggaattctacttcctccttcaattctcagcttg1980 gagttcaagaacaaagacgacatgccctatatgtctcaggcccaggaaatccacctccaa2040 gagaaggaggcagaagaaccagagaagcccacaaaggaaaaagaggaagaggacatggag2100 ctcacagcaatgttgggacgaaacaacggggagtcctccaggaagaaggatgaagaggaa2160 gttcagagcaagcaccggttaatccccctcggcagaaaaatctatgaattctacaatgca2220 cccatcgtgaagttctggttctacacactggcgtatatcggatacctgatgctcttcaac2280 tatatcgtgttagtgaagatggaacgctggccgtccacccaggaatggatcgtaatctcc2340 tatattttcaccctgggaatagaaaagatgagagagattctgatgtcagagccagggaag2400 ttgctacagaaagtgaaggtatggctgcaggagtactggaatgtcacggacctcatcgcc2460 atccttctgttttctgtcggaatgatccttcgtctccaagaccagcccttcaggagtgac2520 gggagggtcatctactgcgtgaacatcatttactggtatatccgtctcctagacatcttc2580 ggcgtgaacaagtatttgggcccgtatgtaatgatgattggaaaaatgatgatagacatg2640 atgtactttgtcatcattatgctggtggttctgatgagctttggggtcgccaggcaagcc2700 atcctttttcccaatgaggagccatcatggaaactggccaagaacatcttctacatgccc2760 tattggatgatttatggggaagtgtttgcggaccagatagaccctccctgtggacagaat2820 gagacccgagaggatggtaaaataatccagctgcctccctgcaagacaggagcttggatc2880 gtgccggccatcatggcctgctacctcttagtggcaaacatcttgctggtcaacctcctc2940 attgctgtctttaacaatacattttttgaagtaaaatcgatatccaaccaagtctggaag3000 tttcagaggtatcagctcatcatgactttccatgaaaggccagttctgcccccaccactg3060 atcatcttcagccacatgaccatgatattccagcacctgtgctgccgatggaggaaacac3120 gagagcgacccggatgaaagggactacggcctgaaactcttcataaccgatgatgagctc3180 aagaaagtacatgactttgaagagcaatgcatagaagaatacttcagagaaaaggatgat3240 cggttcaactcatctaatgatgagaggatacgggtgacttcagaaagggtggagaacatg3300 tctatgcggctggaggaagtcaacgagagagagcactccatgaaggcttcactccagacc3360 gtggacatccggctggcgcagctggaagaccttatcgggcgcatggccacggccctggag3420 cgcctgacaggtctggagcgggccgagtccaacaaaatccgctcgaggacctcgtcagac3480 tgcacggacgccgcctacattgtccgtcagagcagcttcaacagccaggaagggaacacc3540 ttcaagctccaagagagtatagaccctgcagagcatcctctttattcagtataa 3594 <210> 10 <211> 1197 <212> PRT
<213> homo Sapiens <400> 10 Met Tyr Val Arg Val Ser Phe Asp Thr Lys Pro Asp Leu Leu Leu His Leu Met Thr Lys Glu Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser Val His Gly Gly Leu Gln Asn Phe Glu Leu Gln Pro Lys Leu Lys Gln Val Phe Gly Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp Ile Phe Thr Gly Gly Val Asn Thr Gly Val Ile Arg His Val Gly Asp Ala Leu Lys Asp His Ala Ser Lys Ser Arg Gly Lys Ile Cys Thr Ile Gly Ile Ala Pro Trp Gly Ile Val Glu Asn Gln Glu Asp Leu Ile Gly Arg Asp Val Val Arg Pro Tyr Gln Thr Met Ser Asn Pro Met Ser Lys Leu Thr Val Leu Asn Ser Met His Ser His Phe Ile Leu Ala Asp Asn Gly Thr Thr Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Gln Leu Glu Lys His Ile Ser Leu Gln Lys Ile Asn Thr Arg Cys Leu Pro Phe Phe Ser Leu Asp Ser Arg Leu Phe Tyr Ser Phe Trp Gly Ser Cys Gln Leu Asp Ser Val Gly Ile Gly Gln Gly Val Pro Val Val Ala Leu Ile Val Glu Gly Gly Pro Asn Val Ile Ser Ile Val Leu Glu Tyr Leu Arg Asp Thr Pro Pro Val Pro Val Val Val Cys Asp Gly Ser Gly Arg Ala Ser Asp Ile Leu Ala Phe Gly His Lys Tyr Ser Glu Glu Gly Gly Leu Ile Asn Glu Ser Leu Arg Asp Gln Leu Leu Val Thr Ile Gln Lys Thr Phe Thr Tyr Thr Arg Thr Gln Ala Gln His Leu Phe Ile Ile Leu Met Glu Cys Met Lys Lys Lys Glu Leu Ile Thr Val Phe Arg Met Gly Ser Glu Gly His Gln Asp Ile Asp Leu Ala Ile Leu Thr Ala Leu Leu Lys Gly Ala Asn Ala Ser Ala Pro Asp Gln Leu Ser Leu Ala Leu Ala Trp Asn Arg Val Asp Ile Ala Arg Ser Gln Ile Phe Ile Tyr Gly Gln Gln Trp Pro Val Gly Ser Leu Glu Gln Ala Met Leu Asp Ala Leu Val Leu Asp Arg Val Asp Phe Val Lys Leu Leu Ile Glu Asn Gly Val Ser Met His Arg Phe Leu Thr Ile Ser Arg Leu Glu Glu Leu Tyr Asn Thr Arg His Gly Pro Ser Asn Thr Leu Tyr His Leu Val Arg Asp Val Lys Lys Gly Asn Leu Pro Pro Asp Tyr Arg Ile Ser Leu Ile Asp Ile Gly Leu Val Ile Glu Tyr Leu Met Gly Gly Ala Tyr Arg Cys Asn Tyr Thr Arg Lys Arg Phe Arg Thr Leu Tyr His Asn Leu Phe Gly Pro Lys Arg Pro Lys Ala Leu Lys Leu Leu Gly Met Glu Asp Asp Ile Pro Leu Arg Arg Gly Arg Lys Thr Thr Lys Lys Arg Glu Glu Glu Val Asp Ile Asp Leu Asp Asp Pro Glu Ile Asn His Phe Pro Phe Pro Phe His Glu Leu Met Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala Leu Phe Phe Trp Gln His Gly Glu Glu Ala Met Ala Lys Ala Leu Val Ala Cys Lys Leu Cys Lys Ala Met Ala His Glu Ala Ser Glu Asn Asp Met Val Asp Asp Ile Ser Gln Glu Leu Asn His Asn Ser Arg Asp Phe Gly Gln Leu Ala Val Glu Leu Leu Asp Gln Ser Tyr Lys Gln Asp Glu Gln Leu Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ala Thr Cys Leu Gln Leu Ala Val Ala Ala Lys His Arg Asp Phe Ile Ala His Thr Cys Ser Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg Leu Arg Met Arg Lys Asn Ser Gly Leu Lys Val Ile Leu Gly Ile Leu Leu Pro Pro Ser Ile Leu Ser Leu Glu Phe Lys Asn Lys Asp Asp Met Pro Tyr Met Ser Gln Ala Gln Glu Ile His Leu Gln Glu Lys Glu Ala Glu Glu Pro Glu Lys Pro Thr Lys Glu Lys Glu Glu Glu Asp Met Glu Leu Thr Ala Met Leu Gly Arg Asn Asn Gly Glu Ser Ser Arg Lys Lys Asp Glu Glu Glu Val Gln Ser Lys His Arg Leu Ile Pro Leu Gly Arg Lys Ile Tyr Glu Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Leu Ala Tyr Ile Gly Tyr Leu Met Leu Phe Asn Tyr Ile Val Leu Val Lys Met Glu Arg Trp Pro Ser Thr Gln Glu Trp Ile Val Ile Ser Tyr Ile Phe Thr Leu Gly Ile Glu Lys Met Arg Glu Ile Leu Met Ser Glu Pro Gly Lys Leu Leu Gln Lys Val Lys Val Trp Leu Gln Glu Tyr Trp Asn Val Thr Asp Leu Ile Ala Ile Leu Leu Phe Ser Val Gly Met Ile Leu Arg Leu Gln Asp Gln Pro Phe Arg Ser Asp Gly Arg Val Ile Tyr Cys Val Asn Ile Ile Tyr Trp Tyr Ile Arg Leu Leu Asp Ile Phe Gly Val Asn Lys Tyr Leu Gly Pro Tyr Val Met Met Ile Gly Lys Met Met Ile Asp Met Met Tyr Phe Val Ile Ile Met Leu Val Val Leu Met Ser Phe Gly Val Ala Arg Gln Ala Ile Leu Phe Pro Asn Glu Glu Pro Ser Trp Lys Leu Ala Lys Asn Ile Phe Tyr Met Pro Tyr Trp Met Ile Tyr Gly Glu Val Phe Ala Asp Gln Ile Asp Pro Pro Cys Gly Gln Asn Glu Thr Arg Glu Asp Gly Lys Ile Ile Gln Leu Pro Pro Cys Lys Thr Gly Ala Trp Ile Val Pro Ala Ile Met Ala Cys Tyr Leu Leu Val Ala Asn Ile Leu Leu Val Asn Leu Leu Ile Ala Val Phe Asn Asn Thr Phe Phe Glu Val Lys Ser Ile Ser Asn Gln Val Trp Lys Phe Gln Arg Tyr Gln Leu Ile Met Thr Phe His Glu Arg Pro Val Leu Pro Pro Pro Leu Ile Ile Phe Ser His Met Thr Met Ile Phe Gln His Leu Cys Cys Arg Trp Arg Lys His Glu Ser Asp Pro Asp Glu Arg Asp Tyr Gly Leu Lys Leu Phe Ile Thr Asp Asp Glu Leu Lys Lys Val His Asp Phe Glu Glu Gln Cys Ile Glu Glu Tyr Phe Arg Glu Lys Asp Asp Arg Phe Asn Ser Ser Asn Asp Glu Arg Ile Arg Val Thr Ser Glu Arg Val Glu Asn Met Ser Met Arg Leu Glu Glu Val Asn Glu Arg Glu His Ser Met Lys Ala Ser Leu Gln Thr Val Asp Ile Arg Leu Ala Gln Leu Glu Asp Leu Ile Gly Arg Met Ala Thr Ala Leu Glu Arg Leu Thr Gly Leu Glu Arg Ala Glu Ser Asn Lys Ile Arg Ser Arg Thr Ser Ser Asp Cys Thr Asp Ala Ala Tyr Ile Val Arg Gln Ser Ser Phe Asn Ser Gln Glu Gly Asn Thr Phe Lys Leu Gln Glu Ser Ile Asp Pro Ala Glu His Pro Leu Tyr Ser Val <210> 11 <211> 4740 <212> DNA
<213> homo sapiens <400>

atgtatgtgcgagtatcttttgatacaaaacctgatctcctcttacacctgatgaccaag 60 gaatggcagttggagcttcccaagcttctcatctctgtccatgggggcctgcagaacttt 120 gaactccagccaaaactcaagcaagtctttgggaaagggctcatcaaagcagcaatgaca 180 actggagcgtggatattcactggaggggttaacacaggtgttattcgtcatgttggcgat 240 gccttgaaggatcatgcctctaagtctcgaggaaagatatgcaccataggtattgccccc 300 tggggaattgtggaaaaccaggaggacctcattggaagagatgttgtccggccataccag 360 accatgtccaatcccatgagcaagctcactgttctcaacagcatgcattcccacttcatt 420 ctggctgacaacgggaccactggaaaatatggagcagaggtgaaacttcgaagacaactg 480 gaaaagcatatttcactccagaagataaacacaagatgcctgccgtttttctctcttgac 540 tcccgcttgttttattcattttggggtagttgccagttagactcagttggaatcggtcaa 600 ggtgttcctgtggtggcactcatagtggaaggaggacccaatgtgatctcgattgttttg 660 gagtaccttcgagacacccctcccgtgccagtggttgtctgtgatgggagtggacgggca 720 tcggacatcctggcctttgggcataaatactcagaagaaggcggactgataaatgaatct 780 ttgagggaccagctgttggtgactatacagaagactttcacatacactcgaacccaagct 840 cagcatctgttcatcatcctcatggagtgcatgaagaagaaggaattgattacggtattt 900 cggatgggatcagaaggacaccaggacattgatttggctatcctgacagctttactcaaa 960 ggagccaatgcctcggccccagaccaactgagcttagctttagcctggaacagagtcgac 1020 atcgctcgcagccagatctttatttacgggcaacagtggccggtgggatctctggagcaa 1080 gccatgttggatgccttagttctggacagagtggattttgtgaaattactCatagagaat 1140 ggagtaagcatgcaccgttttctcaccatctccagactagaggaattgtacaatacgaga 1200 catgggccctcaaatacattgtaccacttggtcagggatgtcaaaaaggggaacctgccc 1260 ccagactacagaatcagcctgattgacatcggcctggtgatcgagtacctgatgggcggg 1320 gcttatcgctgcaactacacgcgcaagcgcttccggaccctctaccacaacctcttcggc 1380 cccaagaggcccaaagccttgaaactgctgggaatggaggatgatattcccttgaggcga 1440 ggaagaaagacaaccaagaaacgtgaagaagaggtggacattgacttggatgatcctgag 1500 atcaaccacttccccttccctttccatgagctcatggtgtgggctgttctcatgaagcgg 1560 cagaagatggccctgttcttctggcagcacggtgaggaggccatggccaaggccctggtg 1620 gcctgcaagctctgcaaagccatggctcatgaggcctctgagaacgacatggttgacgac 1680 atttcccaggagctgaatcacaattccagagactttggccagctggctgtggagctcctg 1740 gaccagtcctacaagcaggacgaacagctggccatgaaactgctgacgtatgagctgaag 1800 aactggagcaacgccacgtgcctgcagcttgccgtggctgccaaacaccgcgacttcatc 1860 gcgcacacgtgcagccagatgctgctcaccgacatgtggatgggccggctccgcatgcgc 1920 aagaactcaggcctcaaggtaattctgggaattctacttcctccttcaattctcagcttg 1980 gagttcaagaacaaagacgacatgccctatatgtctcaggcccaggaaatccacctccaa 2040 gagaaggaggcagaagaaccagagaagcccacaaaggaaaaagaggaagaggacatggag 2100 ctcacagcaatgttgggacgaaacaacggggagtcctccaggaagaaggatgaagaggaa 2160 gttcagagcaagcaccggttaatccccctcggcagaaaaatctatgaattctacaatgca 2220 cccatcgtgaagttctggttctacacactggcgtatatcggatacctgatgctcttcaac 2280 tatatcgtgttagtgaagatggaacgctggccgtccacccaggaatggatcgtaatctcc 2340 tatattttcaccctgggaatagaaaagatgagagagattctgatgtcagagccagggaag 2400 ttgctacagaaagtgaaggtatggctgcaggagtactggaatgtcacggacctcatcgcc 2460 atccttctgttttctgtcggaatgatccttcgtctccaagaccagcccttcaggagtgac 2520 gggagggtcatctactgcgtgaacatcatttactggtatatccgtctcctagacatcttc 2580 ggcgtgaacaagtatttgggcccgtatgtaatgatgattggaaaaatgatgatagacatg 2640 atgtactttgtcatcattatgctggtggttctgatgagctttggggtcgccaggcaagcc 2700 atcctttttcccaatgaggagccatcatggaaactggccaagaacatcttctacatgccc 2760 tattggatgatttatggggaagtgtttgcggaccagatagaccctccctgtggacagaat 2820 gagacccgagaggatggtaaaataatccagctgcctccctgcaagacaggagcttggatc 2880 gtgccggccatcatggcctgctacctcttagtggcaaacatcttgctggtcaacctcctc 2940 attgctgtctttaacaatacattttttgaagtaaaatcgatatccaaccaagtctggaag3000 tttcagaggtatcagctcatcatgactttccatgaaaggccagttctgcccccaccactg3060 atcatcttcagccacatgaccatgatattccagcacctgtgctgccgatggaggaaacac3120 gagagcgacccggatgaaagggactacggcctgaaactcttcataaccgatgatgagctc3180 aagaaagtacatgactttgaagagcaatgcatagaagaatacttcagagaaaaggatgat3240 cggttcaactcatctaatgatgagaggatacgggtgacttcagaaagggtggagaacatg3300 tctatgcggctggaggaagtcaacgagagagagcactccatgaaggcttcactccagacc3360 gtggacatccggctggcgcagctggaagaccttatcgggcgcatggccacggccctggag3420 cgcctgacaggtctggagcgggccgagtccaacaaaatccgctcgaggacctcgtcagac3480 tgcacggacgccgcctacattgtccgtcagagcagcttcaacagccaggaagggaacacc3540 ttcaagctccaagagagtatagaccctgcaggtgaggagaccatgtccccaacttctcca3600 accttaatgccccgtatgcgaagccattctttctattcggtcaatatgaaagacaaaggt3660 ggtatagaaaagttggaaagtatttttaaagaaaggtccctgagcctacaccgggctact3720 agttcccactctgtagcaaaagaacccaaagctcctgcagcccctgccaacaccttggcc3780 attgttcctgattccagaagaccatcatcgtgtatagacatctatgtctctgctatggat3840 gagctccactgtgatatagaccctctggacaattccgtgaacatccttgggctaggcgag3900 ccaagcttttcaactccagtaccttccacagccccttcaagtagtgcctatgcaacactt3960 gcacccacagacagacctccaagccggagcattgattttgaggacatcacctccatggac4020 actagatctttttcttcagactacacccacctcccagaatgccaaaacccctgggactca4080 gagcctccgatgtaccacaccattgagcgttccaaaagtagccgctacctagccaccaca4140 ccctttcttctagaagaggctcccattgtgaaatctcatagctttatgttttccccctca4200 aggagctattatgccaactttggggtgcctgtaaaaacagcagaatacacaagtattaca4260 gactgtattgacacaaggtgtgtcaatgcccctcaagcaattgcggacagagctgccttc4320 cctggaggtcttggagacaaagtggaggacttaacttgctgccatccagagcgagaagca4380 gaactgagtcaccccagctctgacagtgaggagaatgaggccaaaggccgcagagccacc4440 attgcaatatcctcccaggagggtgataactcagagagaaccctgtccaacaacatcact4500 gttcccaagatagagcgcgccaacagctactcggcagaggagccaagtgcgccatatgca4560 cacaccaggaagagcttctccatcagtgacaaactcgacaggcagcggaacacagcaagc4620 ctgcgaaatcccttccagagaagcaagtcctccaagccggagggccgaggggacagcctg4680 tccatgaggaaactgtccagaacatcggctttccaaagctttgaaagcaagcacacctaa4740 <210> 12 <211> 1579 <212> PRT
<213> homo Sapiens <400> 12 Met Tyr Val Arg Val Ser Phe Asp Thr Lys Pro Asp Leu Leu Leu His Leu Met Thr Lys Glu Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser Val His Gly Gly Leu Gln Asn Phe Glu Leu Gln Pro Lys Leu Lys Gln Val Phe Gly Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp Ile Phe Thr Gly Gly Val Asn Thr Gly Val Ile Arg His Val Gly Asp Ala Leu Lys Asp His Ala Ser Lys Ser Arg Gly Lys Ile Cys Thr Ile Gly Ile Ala Pro Trp Gly Ile Val Glu Asn Gln Glu Asp Leu Ile Gly Arg Asp Val Val Arg Pro Tyr Gln Thr Met Ser Asn Pro Met Ser Lys Leu Thr Val Leu Asn Ser Met His Ser His Phe Ile Leu Ala Asp Asn Gly Thr Thr Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Gln Leu Glu Lys His Ile Ser Leu Gln Lys Ile Asn Thr Arg Cys Leu Pro Phe Phe Ser Leu Asp Ser Arg Leu Phe Tyr Ser Phe Trp Gly Ser Cys Gln Leu Asp Ser Val Gly Ile Gly Gln Gly Val Pro Val Val Ala Leu Ile Val Glu Gly Gly Pro Asn Val Ile Ser Ile Val Leu Glu Tyr Leu Arg Asp Thr Pro Pro Val Pro Val Val Val Cys Asp Gly Ser Gly Arg Ala Ser Asp Ile Leu Ala Phe Gly His Lys Tyr Ser Glu Glu Gly Gly Leu Ile Asn Glu Ser Leu Arg Asp Gln Leu Leu Val Thr Ile Gln Lys Thr Phe Thr Tyr Thr Arg Thr Gln Ala Gln His Leu Phe Ile Ile Leu Met Glu Cys Met Lys Lys Lys Glu Leu Ile Thr Val Phe Arg Met Gly Ser Glu Gly His Gln Asp Ile Asp Leu Ala Ile Leu Thr Ala Leu Leu Lys Gly Ala Asn Ala Ser Ala Pro Asp Gln Leu Ser Leu Ala Leu Ala Trp Asn Arg Val Asp Ile Ala Arg Ser Gln Ile Phe Ile Tyr Gly Gln Gln Trp Pro Val Gly Ser Leu Glu Gln Ala Met Leu Asp Ala Leu Val Leu Asp Arg Val Asp Phe Val Lys Leu Leu Ile Glu Asn Gly Val Ser Met His Arg Phe Leu Thr Ile Ser Arg Leu Glu Glu Leu Tyr Asn Thr Arg His Gly Pro Ser Asn Thr Leu Tyr His Leu Val Arg Asp Val Lys Lys Gly Asn Leu Pro Pro Asp Tyr Arg Ile Ser Leu Ile Asp Ile Gly Leu Val Ile Glu Tyr Leu Met Gly Gly Ala Tyr Arg Cys Asn Tyr Thr Arg Lys Arg Phe Arg Thr Leu Tyr His Asn Leu Phe Gly Pro Lys Arg Pro Lys Ala Leu Lys Leu Leu Gly Met Glu Asp Asp Ile Pro Leu Arg Arg Gly Arg Lys Thr Thr Lys Lys Arg Glu Glu Glu Val Asp Ile Asp Leu Asp Asp Pro Glu Ile Asn His Phe Pro Phe Pro Phe His Glu Leu Met Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala Leu Phe Phe Trp Gln His Gly Glu Glu Ala Met Ala Lys Ala Leu Val Ala Cys Lys Leu Cys Lys Ala Met Ala His Glu Ala Ser Glu Asn Asp Met Val Asp Asp Ile Ser Gln Glu Leu Asn His Asn Ser Arg Asp Phe Gly Gln Leu Ala Val Glu Leu Leu Asp Gln Ser Tyr Lys Gln Asp Glu Gln Leu Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ala Thr Cys Leu Gln Leu Ala Val Ala Ala Lys His Arg Asp Phe Ile Ala His Thr Cys Ser Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg Leu Arg Met Arg Lys Asn Ser Gly Leu Lys Val Ile Leu Gly Ile Leu Leu Pro Pro Ser Ile Leu Ser Leu Glu Phe Lys Asn Lys Asp Asp Met Pro Tyr Met Ser Gln Ala Gln Glu Ile His Leu Gln Glu Lys Glu Ala Glu Glu Pro Glu Lys Pro Thr Lys Glu Lys Glu Glu Glu Asp Met Glu Leu Thr Ala Met Leu Gly Arg Asn Asn Gly Glu Ser Ser Arg Lys Lys Asp Glu Glu Glu Val Gln Ser Lys His Arg Leu Ile Pro Leu Gly Arg Lys Ile Tyr Glu Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Leu Ala Tyr Ile Gly Tyr Leu Met Leu Phe Asn Tyr Ile Val Leu Val Lys Met Glu Arg Trp Pro Ser Thr Gln Glu Trp Ile Val Ile Ser Tyr Ile Phe Thr Leu Gly Ile Glu Lys Met Arg Glu Ile Leu Met Ser Glu Pro Gly Lys Leu Leu Gln Lys Val Lys Val Trp Leu Gln Glu Tyr Trp Asn Val Thr Asp Leu Ile Ala Ile Leu Leu Phe Ser Val Gly Met Ile Leu Arg Leu Gln Asp Gln Pro Phe Arg Ser Asp Gly Arg Val Ile Tyr Cys Val Asn Ile Ile Tyr Trp Tyr Ile Arg Leu Leu Asp Ile Phe Gly Val Asn Lys Tyr Leu Gly Pro Tyr Val Met Met Ile Gly Lys Met Met Ile Asp Met Met Tyr Phe Val Ile Ile Met Leu Val Val Leu Met Ser Phe Gly Val Ala Arg Gln Ala Ile Leu Phe Pro Asn Glu Glu Pro Ser Trp Lys Leu Ala Lys Asn Ile Phe Tyr Met Pro Tyr Trp Met Ile Tyr Gly Glu Val Phe Ala Asp Gln Ile Asp Pro Pro Cys Gly Gln Asn Glu Thr Arg Glu Asp Gly Lys Ile Ile Gln Leu Pro Pro Cys Lys Thr Gly Ala Trp Ile Val Pro Ala Ile Met Ala Cys Tyr Leu Leu Val Ala Asn Ile Leu Leu 965 97.0 975 Val Asn Leu Leu Ile Ala Val Phe Asn Asn Thr Phe Phe Glu Val Lys Ser Ile Ser Asn Gln Val Trp Lys Phe Gln Arg Tyr Gln Leu Ile Met Thr Phe His Glu Arg Pro Val Leu Pro Pro Pro Leu Ile Ile Phe Ser His Met Thr Met Ile Phe Gln His Leu Cys Cys Arg Trp Arg Lys His Glu Ser Asp Pro Asp Glu Arg Asp Tyr Gly Leu Lys Leu Phe Ile Thr Asp Asp Glu Leu Lys Lys Val His Asp Phe Glu Glu Gln Cys Ile Glu Glu Tyr Phe Arg Glu Lys Asp Asp Arg Phe Asn Ser Ser Asn Asp Glu Arg Ile Arg Val Thr Ser Glu Arg Val Glu Asn Met Ser Met Arg Leu Glu Glu Val Asn Glu Arg Glu His Ser Met Lys Ala Ser Leu Gln Thr Val Asp Ile Arg Leu Ala Gln Leu Glu Asp Leu Ile Gly Arg Met Ala Thr Ala Leu Glu Arg Leu Thr Gly Leu Glu Arg Ala Glu Ser Asn Lys Ile Arg Ser Arg Thr Ser Ser Asp Cys Thr Asp Ala Ala Tyr Ile Val Arg Gln Ser Ser Phe Asn Ser Gln Glu Gly Asn Thr Phe Lys Leu Gln Glu Ser Ile Asp Pro Ala Gly Glu Glu Thr Met Ser Pro Thr Ser Pro Thr Leu Met Pro Arg Met Arg Ser His Ser Phe Tyr Ser Val Asn Met Lys Asp Lys Gly Gly Ile Glu Lys Leu Glu Ser Ile Phe Lys Glu Arg Ser Leu Ser Leu His Arg Ala Thr Ser Ser His Ser Val Ala Lys Glu Pro Lys Ala Pro Ala Ala Pro Ala Asn Thr Leu Ala Ile Val Pro Asp Ser Arg Arg Pro Ser Ser Cys Ile Asp Ile Tyr Val Ser Ala Met Asp Glu Leu His Cys Asp Ile Asp Pro Leu Asp Asn Ser Val Asn Ile Leu Gly Leu Gly Glu Pro Ser Phe Ser Thr Pro Val Pro Ser Thr Ala Pro Ser Ser Ser Ala Tyr Ala Thr Leu Ala Pro Thr Asp Arg Pro Pro Ser Arg Ser Ile Asp Phe Glu Asp Ile Thr Ser Met Asp Thr Arg Ser Phe Ser Ser Asp Tyr Thr His Leu Pro Glu Cys Gln Asn Pro Trp Asp Ser Glu Pro Pro Met Tyr His Thr Ile Glu Arg Ser Lys Ser Ser Arg Tyr Leu Ala Thr Thr Pro Phe Leu Leu Glu Glu Ala Pro Ile Val Lys Ser His Ser Phe Met Phe Ser Pro Ser Arg Ser Tyr Tyr Ala Asn Phe Gly Val Pro Val Lys Thr Ala Glu Tyr Thr Ser Ile Thr Asp Cys Ile Asp Thr Arg Cys Val Asn Ala Pro Gln Ala Ile Ala Asp Arg Ala Ala Phe Pro Gly Gly Leu Gly Asp Lys Val Glu Asp Leu Thr Cys Cys His Pro Glu Arg Glu Ala Glu Leu Ser His Pro Ser Ser Asp Ser Glu Glu Asn Glu Ala Lys Gly Arg Arg Ala Thr Ile Ala Ile Ser Ser Gln Glu Gly Asp Asn Ser Glu Arg Thr Leu Ser Asn Asn Ile Thr Val Pro Lys Ile Glu Arg Ala Asn Ser Tyr Ser Ala Glu Glu Pro Ser Ala Pro Tyr Ala His Thr Arg Lys Ser Phe Ser Ile Ser Asp Lys Leu Asp Arg Gln Arg Asn Thr Ala Ser Leu Arg Asn Pro Phe Gln Arg Ser Lys Ser Ser Lys Pro Glu Gly Arg Gly Asp Ser Leu Ser Met Arg Lys Leu Ser Arg Thr Ser Ala Phe Gln Ser Phe Glu Ser Lys His Thr <210> 13 <211> 2337 <212> DNA
<213> homo sapiens <400> 13 atgtatgtgcgagtatcttttgatacaaaacctgatctcctcttacacctgatgaccaag 60 gaatggcagttggagcttcccaagcttctcatctctgtccatgggggcctgcagaacttt 120 gaactccagccaaaactcaagcaagtctttgggaaagggctcatcaaagcagcaatgaca 180 actggagcgtggatattcactggaggggttaacacaggtgttattcgtcatgttggcgat 240 gccttgaaggatcatgcctctaagtctcgaggaaagatatgcaccataggtattgccccc 300 tggggaattgtggaaaaccaggaggacctcattggaagagatgttgtccggccataccag 360 accatgtccaatcccatgagcaagctcactgttctcaacagcatgcattcccacttcatt 420 ctggctgacaacgggaccactggaaaatatggagcagaggtgaaacttcgaagacaactg 480 gaaaagcatatttcactccagaagataaacacaagaatcggtcaaggtgttcctgtggtg 540 gcactcatagtggaaggaggacccaatgtgatctcgattgttttggagtaccttcgagac 600 acccctcccgtgccagtggttgtctgtgatgggagtggacgggcatcggacatcctggcc660 tttgggcataaatactcagaagaaggcggactgataaatgaatctttgagggaccagctg720 ttggtgactatacagaagactttcacatacactcgaacccaagctcagcatctgttcatc780 atcctcatggagtgcatgaagaagaaggaattgattacggtatttcggatgggatcagaa840 ggacaccaggacattgatttggctatcctgacagctttactcaaaggagccaatgcctcg900 gccccagaccaactgagcttagctttagcctggaacagagtcgacatcgctcgcagccag960 atctttatttacgggcaacagtggccggtgggatctctggagcaagccatgttggatgcc1020 ttagttctggacagagtggattttgtgaaattactcatagagaatggagtaagcatgcac1080 cgttttctcaccatctccagactagaggaattgtacaatacgagacatgggccctcaaat1140 acattgtaccacttggtcagggatgtcaaaaaggggaacctgcccccagactacagaatc1200 agcctgattgacatcggcctggtgatcgagtacctgatgggcggggcttatcgctgcaac1260 tacacgcgcaagcgcttccggaccctctaccacaacctcttcggccccaagaggcccaaa1320 gccttgaaactgctgggaatggaggatgatattcccttgaggcgaggaagaaagacaacc1380 aagaaacgtgaagaagaggtggacattgacttggatgatcctgagatcaaccacttcccc1440 ttccctttccatgagctcatggtgtgggctgttctcatgaagcggcagaagatggccctg1500 ttcttctggcagcacggtgaggaggccatggccaaggccctggtggcctgcaagctctgc1560 aaagccatggctcatgaggcctctgagaacgacatggttgacgacatttcccaggagctg1620 aatcacaattccagagactttggccagctggctgtggagctcctggaccagtcctacaag1680 caggacgaacagctggccatgaaactgctgacgtatgagctgaagaactggagcaacgcc1740 acgtgcctgcagcttgccgtggctgccaaacaccgcgacttcatcgcgcacacgtgcagc1800 cagatgctgctcaccgacatgtggatgggccggctccgcatgcgcaagaactcaggcctc1860 aaggtaattctgggaattctacttcctccttcaattctcagcttggagttcaagaacaaa1920 gacgacatgccctatatgtctcaggcccaggaaatccacctccaagagaaggaggcagaa1980 gaaccagagaagcccacaaaggaaaaagaggaagaggacatggagctcacagcaatgttg2040 ggacgaaacaacggggagtcctccaggaagaaggatgaagaggaagttcagagcaagcac2100 cggttaatccccctcggcagaaaaatctatgaattctacaatgcacccatcgtgaagttc2160 tggttctacacactggcgtatatcggatacctgatgctcttcaactatatcgtgttagtg2220 aagatggaacgctggccgtccacccaggaatggatcgtaatctcctatattttcaccctt2280 gttccagctggttgtctgcacttcggtcttcccattcatggtgccttttcttcttga 2337 <210> 14 <211> 778 <212> PRT
<213> homo sapiens <400> 14 Met Tyr Val Arg Val Ser Phe Asp Thr Lys Pro Asp Leu Leu Leu His Leu Met Thr Lys Glu Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser Val His Gly Gly Leu Gln Asn Phe Glu Leu Gln Pro Lys Leu Lys Gln Val Phe Gly Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp Ile Phe Thr Gly Gly Val Asn Thr Gly Val Ile Arg His Val Gly Asp Ala Leu Lys Asp His Ala Ser Lys Ser Arg Gly Lys Ile Cys Thr Ile Gly Ile Ala Pro Trp Gly Ile Val Glu Asn Gln Glu Asp Leu Ile Gly Arg Asp Val Val Arg Pro Tyr Gln Thr Met Ser Asn Pro Met Ser Lys Leu Thr Val Leu Asn Ser Met His Ser His Phe Ile Leu Ala Asp Asn Gly Thr Thr Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Gln Leu Glu Lys His Ile Ser Leu Gln Lys Ile Asn Thr Arg Ile Gly Gln Gly Val Pro Val Val Ala Leu Ile Val Glu Gly Gly Pro Asn Val Ile Ser Ile Val Leu Glu Tyr Leu Arg Asp Thr Pro Pro Val Pro Val Val Val Cys Asp Gly Ser Gly Arg Ala Ser Asp Ile Leu Ala Phe Gly His Lys Tyr Ser Glu Glu Gly Gly Leu Ile Asn Glu Ser Leu Arg Asp Gln Leu Leu Val Thr Ile Gln Lys Thr Phe Thr Tyr Thr Arg Thr Gln Ala Gln His Leu Phe Ile Ile Leu Met Glu Cys Met Lys Lys Lys Glu Leu Ile Thr Val Phe Arg Met Gly Ser Glu Gly His Gln Asp Ile Asp Leu Ala Ile Leu Thr Ala Leu Leu Lys Gly Ala Asn Ala Ser Ala Pro Asp Gln Leu Ser Leu Ala Leu Ala Trp Asn Arg Val Asp Ile Ala Arg Ser Gln Ile Phe Ile Tyr Gly Gln Gln Trp Pro Val Gly Ser Leu Glu Gln Ala Met Leu Asp Ala Leu Val Leu Asp Arg Val Asp Phe Val Lys Leu Leu Ile Glu Asn Gly Val Ser Met His Arg Phe Leu Thr Ile Ser Arg Leu Glu Glu Leu Tyr Asn Thr Arg His Gly Pro Ser Asn Thr Leu Tyr His Leu Val Arg Asp Val Lys Lys Gly Asn Leu Pro Pro Asp Tyr Arg Ile Ser Leu Ile Asp Ile Gly Leu Val Ile Glu Tyr Leu Met Gly Gly Ala Tyr Arg Cys Asn Tyr Thr Arg Lys Arg Phe Arg Thr Leu Tyr His Asn Leu Phe Gly Pro Lys Arg Pro Lys Ala Leu Lys Leu Leu Gly Met Glu Asp Asp Ile Pro Leu Arg Arg Gly Arg Lys Thr Thr Lys Lys Arg Glu Glu Glu Val Asp Ile Asp Leu Asp Asp Pro Glu Ile Asn His Phe Pro Phe Pro Phe His Glu Leu Met Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala Leu Phe Phe Trp Gln His Gly Glu Glu Ala Met Ala Lys Ala Leu Val Ala Cys Lys Leu Cys Lys Ala Met Ala His Glu Ala Ser Glu Asn Asp Met Val Asp Asp Ile Ser Gln Glu Leu Asn His Asn Ser Arg Asp Phe Gly Gln Leu Ala Val Glu Leu Leu Asp Gln Ser Tyr Lys Gln Asp Glu Gln Leu Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ala Thr Cys Leu Gln Leu Ala Val Ala Ala Lys His Arg Asp Phe Ile Ala His Thr Cys Ser Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg Leu Arg Met Arg Lys Asn Ser Gly Leu Lys Val Ile Leu Gly Ile Leu Leu Pro Pro Ser Ile Leu Ser Leu Glu Phe Lys Asn Lys Asp Asp Met Pro Tyr Met Ser Gln Ala Gln Glu Ile His Leu Gln Glu Lys Glu Ala Glu Glu Pro Glu Lys Pro Thr Lys Glu Lys Glu Glu Glu Asp Met Glu Leu Thr Ala Met Leu Gly Arg Asn Asn Gly Glu Ser Ser Arg Lys Lys Asp Glu Glu Glu Val Gln Ser Lys His Arg Leu Ile Pro Leu Gly Arg Lys Ile Tyr Glu Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Leu Ala Tyr Ile Gly Tyr Leu Met Leu Phe Asn Tyr Ile Val Leu Val Lys Met Glu Arg Trp Pro Ser Thr Gln Glu Trp Ile Val Ile Ser Tyr Ile Phe Thr Leu Val Pro Ala Gly Cys Leu His Phe Gly Leu Pro Ile His Gly Ala Phe Ser Ser <210> 15 <211> 2397 <212> DNA
<213> homo sapiens <400>

atgtatgtgcgagtatcttttgatacaaaacctgatctcctcttacacctgatgaccaag60 gaatggcagttggagcttcccaagcttctcatctctgtccatgggggcctgcagaacttt120 gaactccagccaaaactcaagcaagtctttgggaaagggctcatcaaagcagcaatgaca180 actggagcgtggatattcactggaggggttaacacaggtgttattcgtcatgttggcgat240 gccttgaaggatcatgcctctaagtctcgaggaaagatatgcaccataggtattgccccc300 tggggaattgtggaaaaccaggaggacctcattggaagagatgttgtccggccataccag360 accatgtccaatcccatgagcaagctcactgttctcaacagcatgcattcccacttcatt420 ctggctgacaacgggaccactggaaaatatggagcagaggtgaaacttcgaagacaactg480 gaaaagcatatttcactccagaagataaacacaagaatcggtcaaggtgttcctgtggtg540 gcactcatagtggaaggaggacccaatgtgatctcgattgttttggagtaccttcgagac600 acccctcccgtgccagtggttgtctgtgatgggagtggacgggcatcggacatcctggcc660 tttgggcataaatactcagaagaaggcggactgataaatgaatctttgagggaccagctg720 ttggtgactatacagaagactttcacatacactcgaacccaagctcagcatctgttcatc780 atcctcatggagtgcatgaagaagaaggaattgattacggtatttcggatgggatcagaa840 ggacaccaggacattgatttggctatcctgacagctttactcaaaggagccaatgcctcg900 gccccagaccaactgagcttagctttagcctggaacagagtcgacatcgctcgcagccag960 atctttatttacgggcaacagtggccggtgggatctctggagcaagccatgttggatgcc1020 ttagttctggacagagtggattttgtgaaattactcatagagaatggagtaagcatgcac1080 cgttttctcaccatctccagactagaggaattgtacaatacgagacatgggccctcaaat1140 acattgtaccacttggtcagggatgtcaaaaaggggaacctgcccccagactacagaatc1200 agcctgattgacatcggcctggtgatcgagtacctgatgggcggggcttatcgctgcaac1260 tacacgcgcaagcgcttccggaccctctaccacaacctcttcggccccaagaggcccaaa1320 gccttgaaactgctgggaatggaggatgatattcccttgaggcgaggaagaaagacaacc1380 aagaaacgtgaagaagaggtggacattgacttggatgatcctgagatcaaccacttcccc1440 ttccctttccatgagctcatggtgtgggctgttctcatgaagcggcagaagatggccctg1500 ttcttctggcagcacggtgaggaggccatggccaaggccctggtggcctgcaagctctgc1560 aaagccatggctcatgaggcctctgagaacgacatggttgacgacatttcccaggagctg1620 aatcacaattccagagactttggccagctggctgtggagctcctggaccagtcctacaag1680 caggacgaacagctggccatgaaactgctgacgtatgagctgaagaactggagcaacgcc1740 acgtgcctgcagcttgccgtggctgccaaacaccgcgacttcatcgcgcacacgtgcagc1800 cagatgctgctcaccgacatgtggatgggccggctccgcatgcgcaagaactcaggcctc1860 aaggtaattCtgggaattctacttcctccttcaattctcagcttggagttcaagaacaaa1920 gacgacatgccctatatgtctcaggcccaggaaatccacctccaagagaaggaggcagaa1980 gaaccagagaagcccacaaaggaaaaagaggaagaggacatggagctcacagcaatgttg2040 ggacgaaacaacggggagtcctccaggaagaaggatgaagaggaagttcagagcaagcac2100 cggttaatccccctcggcagaaaaatctatgaattctacaatgcacccatcgtgaagttc2160 tggttctacacactggcgtatatcggatacctgatgctcttcaactatatcgtgttagtg2220 aagatggaacgctggccgtccacccaggaatggatcgtaatctcctatattttcaccctg2280 ggaatagaaaagatgagagaggtaacggcttttataaaagaaaacgtaagagaaagacag2340 tggttaagttctatctgtggatggaggggacaggaagatgcctgggatgcaaattaa 2397 <210> 16 <211> 798 <212> PRT
<213> homo sapiens <400> 16 Met Tyr Val Arg Val Ser Phe Asp Thr Lys Pro Asp Leu Leu Leu His Leu Met Thr Lys Glu Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser Val His Gly Gly Leu Gln Asn Phe Glu Leu Gln Pro Lys Leu Lys Gln Val Phe Gly Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp Ile Phe Thr Gly Gly Val Asn Thr Gly Val Ile Arg His Val Gly Asp Ala Leu Lys Asp His Ala Ser Lys Ser Arg Gly Lys Ile Cys Thr Ile Gly Ile Ala Pro Trp Gly Ile Val Glu Asn Gln Glu Asp Leu Ile Gly Arg Asp Val Val Arg Pro Tyr Gln Thr Met Ser Asn Pro Met Ser Lys Leu Thr Val Leu Asn Ser Met His Ser His Phe Ile Leu Ala Asp Asn Gly Thr Thr Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Gln Leu Glu Lys His Ile Ser Leu Gln Lys Ile Asn Thr Arg Ile Gly Gln Gly Val Pro Val Val Ala Leu Ile Val Glu Gly Gly Pro Asn Val Ile Ser Ile Val Leu Glu Tyr Leu Arg Asp Thr Pro Pro Val Pro Val Val Val Cys Asp Gly Ser Gly Arg Ala Ser Asp Ile Leu Ala Phe Gly His Lys Tyr Ser Glu Glu Gly Gly Leu Ile Asn Glu Ser Leu Arg Asp Gln Leu Leu Val Thr Ile Gln Lys Thr Phe Thr Tyr Thr Arg Thr Gln Ala Gln His Leu Phe Ile Ile Leu Met Glu Cys Met Lys Lys Lys Glu Leu Ile Thr Val Phe Arg Met Gly Ser Glu Gly His Gln Asp Ile Asp Leu Ala Ile Leu Thr Ala Leu Leu Lys Gly Ala Asn Ala Ser Ala Pro Asp Gln Leu Ser Leu Ala Leu Ala Trp Asn Arg Val Asp Ile Ala Arg Ser Gln Ile Phe Ile Tyr Gly Gln Gln Trp Pro Val Gly Ser Leu Glu Gln Ala Met Leu Asp Ala Leu Val Leu Asp Arg Val Asp Phe Val Lys Leu Leu Ile Glu Asn Gly Val Ser Met His Arg Phe Leu Thr Ile Ser Arg Leu Glu Glu Leu Tyr Asn Thr Arg His Gly Pro Ser Asn Thr Leu Tyr His Leu Val Arg Asp Val Lys Lys Gly Asn Leu Pro Pro Asp Tyr Arg Ile Ser Leu Ile Asp Ile Gly Leu Val Ile Glu Tyr Leu Met Gly Gly Ala Tyr Arg Cys Asn Tyr Thr Arg Lys Arg Phe Arg Thr Leu Tyr His Asn Leu Phe Gly Pro Lys Arg Pro Lys Ala Leu Lys Leu Leu Gly Met Glu Asp Asp Ile Pro Leu Arg Arg Gly Arg Lys Thr Thr Lys Lys Arg Glu Glu Glu Val Asp Ile Asp Leu Asp Asp Pro Glu Ile Asn His Phe Pro Phe Pro Phe His Glu Leu Met Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala Leu Phe Phe Trp Gln His Gly Glu Glu Ala Met Ala Lys Ala Leu Val Ala Cys Lys Leu Cys Lys Ala Met Ala His Glu Ala Ser Glu Asn Asp Met Val Asp Asp Ile Ser Gln Glu Leu Asn His Asn Ser Arg Asp Phe Gly Gln Leu Ala Val Glu Leu Leu Asp Gln Ser Tyr Lys Gln Asp Glu Gln Leu Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ala Thr Cys Leu Gln Leu Ala Val Ala Ala Lys His Arg Asp Phe Ile Ala His Thr Cys Ser Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg Leu Arg Met Arg Lys Asn Ser Gly Leu Lys Val Ile Leu Gly Ile Leu Leu Pro Pro Ser Ile Leu Ser Leu Glu Phe Lys Asn Lys Asp Asp Met Pro Tyr Met Ser Gln Ala Gln Glu Ile His Leu Gln Glu Lys Glu Ala Glu Glu Pro Glu Lys Pro Thr Lys Glu Lys Glu Glu Glu Asp Met Glu Leu Thr Ala Met Leu Gly Arg Asn Asn Gly Glu Ser Ser Arg Lys Lys Asp Glu Glu Glu Val Gln Ser Lys His Arg Leu Ile Pro Leu Gly Arg Lys Ile Tyr Glu Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Leu Ala Tyr Ile Gly Tyr Leu Met Leu Phe Asn Tyr Ile Val Leu Val Lys Met Glu Arg Trp Pro Ser Thr Gln Glu Trp Ile Val Ile Ser Tyr Ile Phe Thr Leu Gly Ile Glu Lys Met Arg Glu Val Thr Ala Phe Ile Lys Glu Asn Val Arg Glu Arg Gln Trp Leu Ser Ser Ile Cys Gly Trp Arg Gly Gln Glu Asp Ala Trp Asp Ala Asn <210> 17 <211> 2772 <212> DNA
<213> homo sapiens <400> 17 atgtatgtgcgagtatcttttgatacaaaacctgatctcctcttacacctgatgaccaag 60 gaatggcagttggagcttcccaagcttctcatctctgtccatgggggcctgcagaacttt 120 gaactccagccaaaactcaagcaagtctttgggaaagggctcatcaaagcagcaatgaca 180 actggagcgtggatattcactggaggggttaacacaggtgttattcgtcatgttggcgat 240 gccttgaaggatcatgcctctaagtctcgaggaaagatatgcaccataggtattgccccc 300 tggggaattgtggaaaaccaggaggacctcattggaagagatgttgtccggccataccag 360 accatgtccaatcccatgagcaagctcactgttctcaacagcatgcattcccacttcatt 420 ctggctgacaacgggaccactggaaaatatggagcagaggtgaaacttcgaagacaactg 480 gaaaagcatatttcactccagaagataaacacaagaatcggtcaaggtgttcctgtggtg 540 gcactcatagtggaaggaggacccaatgtgatctcgattgttttggagtaccttcgagac 600 acccctcccgtgccagtggttgtctgtgatgggagtggacgggcatcggacatcctggcc 660 tttgggcataaatactcagaagaaggcggactgataaatgaatctttgagggaccagctg 720 ttggtgactatacagaagactttcacatacactcgaacccaagctcagcatctgttcatc 780 atcctcatggagtgcatgaagaagaaggaattgattacggtatttcggatgggatcagaa 840 ggacaccaggacattgatttggctatcctgacagctttactcaaaggagccaatgcctcg 900 gccccagaccaactgagcttagctttagcctggaacagagtcgacatcgctcgcagccag 960 atctttatttacgggcaacagtggccggtgggatctctggagcaagccatgttggatgcc 1020 ttagttctggacagagtggattttgtgaaattactcatagagaatggagtaagcatgcac 1080 cgttttctcaccatctccagactagaggaattgtacaatacgagacatgggccctcaaat 1140 acattgtaccacttggtcagggatgtcaaaaaggggaacctgcccccagactacagaatc 1200 agcctgattgacatcggcctggtgatcgagtacctgatgggcggggcttatcgctgcaac1260 tacacgcgcaagcgcttccggaccctctaccacaacctcttcggccccaagaggcccaaa1320 gccttgaaactgctgggaatggaggatgatattcccttgaggcgaggaagaaagacaacc1380 aagaaacgtgaagaagaggtggacattgacttggatgatcctgagatcaaccacttcccc1440 ttccctttccatgagctcatggtgtgggctgttctcatgaagcggcagaagatggccctg1500 ttcttctggcagcacggtgaggaggccatggccaaggccctggtggcctgcaagctctgc1560 aaagccatggctcatgaggcctctgagaacgacatggttgacgacatttcccaggagctg1620 aatcacaattccagagactttggccagctggctgtggagctcctggaccagtcctacaag1680 caggacgaacagctggccatgaaactgctgacgtatgagctgaagaactggagcaacgcc1740 acgtgcctgcagcttgccgtggctgccaaacaccgcgacttcatcgcgcacacgtgcagc1800 cagatgctgctcaccgacatgtggatgggccggctccgcatgcgcaagaactcaggcctc1860 aaggtaattctgggaattctacttcctccttcaattctcagcttggagttcaagaacaaa1920 gacgacatgccctatatgtctcaggcccaggaaatccacctccaagagaaggaggcagaa1980 gaaccagagaagcccacaaaggaaaaagaggaagaggacatggagctcacagcaatgttg2040 ggacgaaacaacggggagtcctccaggaagaaggatgaagaggaagttcagagcaagcac2100 cggttaatccccctcggcagaaaaatctatgaattctacaatgcacccatcgtgaagttc2160 tggttctacacactggcgtatatcggatacctgatgctcttcaactatatcgtgttagtg2220 aagatggaacgctggccgtccacccaggaatggatcgtaatctcctatattttcaccctg2280 ggaatagaaaagatgagagagattctgatgtcagagccagggaagttgctacagaaagtg2340 aaggtatggctgcaggagtactggaatgtcacggacctcatcgccatccttctgttttct2400 gtcggaatgatccttcgtctccaagaccagcccttcaggagtgacgggagggtcatctac2460 tgcgtgaacatcatttactggtatatccgtctcctagacatcttcggcgtgaacaagtat2520 ttgggcccgtatgtaatgatgattggaaaaatgatgatagacatgatgtactttgtcatc2580 attatgctggtggttctgatgagctttggggtcgccaggcaagccatcctttttcccaat2640 gaggagccatcatggaaactggccaagaacatcttctacatgccctattggatgatttat2700 ggggaagtgtttgcggaccagatagaccgtaagcaagtttatgattctcatacaccaaag2760 tcaggtatttas 2772 <210> 18 <211> 923 <212> PRT
<213> homo Sapiens <400> 18 Met Tyr Val Arg Val Ser Phe Asp Thr Lys Pro Asp Leu Leu Leu His Leu Met Thr Lys Glu Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser Val His Gly Gly Leu Gln Asn Phe Glu Leu Gln Pro Lys Leu Lys Gln Val Phe Gly Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp Ile Phe Thr Gly Gly Val Asn Thr Gly Val Ile Arg His Val Gly Asp Ala Leu Lys Asp His Ala Ser Lys Ser Arg Gly Lys Ile Cys Thr Ile Gly Ile Ala Pro Trp Gly Ile Val Glu Asn Gln Glu Asp Leu Ile Gly Arg Asp Val Val Arg Pro Tyr Gln Thr Met Ser Asn Pro Met Ser Lys Leu Thr Val Leu Asn Ser Met His Ser His Phe Ile Leu Ala Asp Asn Gly Thr Thr Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Gln Leu Glu Lys His Ile Ser Leu Gln Lys Ile Asn Thr Arg Ile Gly Gln Gly Val Pro Val Val Ala Leu Ile Val Glu Gly Gly Pro Asn Val Ile Ser Ile Val Leu Glu Tyr Leu Arg Asp Thr Pro Pro Val Pro Val Val Val Cys Asp Gly Ser Gly Arg Ala Ser Asp Ile Leu Ala Phe Gly His Lys Tyr Ser Glu Glu Gly Gly Leu Ile Asn Glu Ser Leu Arg Asp Gln Leu Leu Val Thr Ile Gln Lys Thr Phe Thr Tyr Thr Arg Thr Gln Ala Gln His Leu Phe Ile Ile Leu Met Glu Cys Met Lys Lys Lys Glu Leu Ile 260 265. 270 Thr Val Phe Arg Met Gly Ser Glu Gly His Gln Asp Ile Asp Leu Ala Ile Leu Thr Ala Leu Leu Lys Gly Ala Asn Ala Ser Ala Pro Asp Gln Leu Ser Leu Ala Leu Ala Trp Asn Arg Val Asp Ile Ala Arg Ser Gln Ile Phe Ile Tyr Gly Gln Gln Trp Pro Val Gly Ser Leu Glu Gln Ala Met Leu Asp Ala Leu Val Leu Asp Arg Val Asp Phe Val Lys Leu Leu Ile Glu Asn Gly Val Ser Met His Arg Phe Leu Thr Ile Ser Arg Leu Glu Glu Leu Tyr Asn Thr Arg His Gly Pro Ser Asn Thr Leu Tyr His Leu Val Arg Asp Val Lys Lys Gly Asn Leu Pro Pro Asp Tyr Arg Ile Ser Leu Ile Asp Ile Gly Leu Val Ile Glu Tyr Leu Met Gly Gly Ala Tyr Arg Cys Asn Tyr Thr Arg Lys Arg Phe Arg Thr Leu Tyr His Asn Leu Phe Gly Pro Lys Arg Pro Lys Ala Leu Lys Leu Leu Gly Met Glu Asp Asp Ile Pro Leu Arg Arg Gly Arg Lys Thr Thr Lys Lys Arg Glu Glu Glu Val Asp Ile Asp Leu Asp Asp Pro Glu Ile Asn His Phe Pro Phe Pro Phe His Glu Leu Met Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala Leu Phe Phe Trp Gln His Gly Glu Glu Ala Met Ala Lys Ala Leu Val Ala Cys Lys Leu Cys Lys Ala Met Ala His Glu Ala Ser Glu Asn Asp Met Val Asp Asp Ile Ser Gln Glu Leu Asn His Asn Ser Arg Asp Phe Gly Gln Leu Ala Val Glu Leu Leu Asp Gln Ser Tyr Lys Gln Asp Glu Gln Leu Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ala Thr Cys Leu Gln Leu Ala Val Ala Ala Lys His Arg Asp Phe Ile Ala His Thr Cys Ser Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg Leu Arg Met Arg Lys Asn Ser Gly Leu Lys Val Ile Leu Gly Ile Leu Leu Pro Pro Ser Ile Leu Ser Leu Glu Phe Lys Asn Lys Asp Asp Met Pro Tyr Met Ser Gln Ala Gln Glu Ile His Leu Gln Glu Lys Glu Ala Glu Glu Pro Glu Lys Pro Thr Lys Glu Lys Glu Glu Glu Asp Met Glu Leu Thr Ala Met Leu Gly Arg Asn Asn Gly Glu Ser Ser Arg Lys Lys Asp Glu Glu Glu Val Gln Ser Lys His Arg Leu Ile Pro Leu Gly Arg Lys Ile Tyr Glu Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Leu Ala Tyr Ile Gly Tyr Leu Met Leu Phe Asn Tyr Ile Val Leu Val Lys Met Glu Arg Trp Pro Ser Thr Gln Glu Trp Ile Val Ile Ser Tyr Ile Phe Thr Leu Gly Ile Glu Lys Met Arg Glu Ile Leu Met Ser Glu Pro Gly Lys Leu Leu Gln Lys Val Lys Val Trp Leu Gln Glu Tyr Trp Asn Val Thr Asp Leu Ile Ala Ile Leu Leu Phe Ser Val Gly Met Ile Leu Arg Leu Gln Asp Gln Pro Phe Arg Ser Asp Gly Arg Val Ile Tyr Cys Val Asn Ile Ile Tyr Trp Tyr Ile Arg Leu Leu Asp Ile Phe Gly Val Asn Lys Tyr Leu Gly Pro Tyr Val Met Met Ile Gly Lys Met Met Ile Asp Met Met Tyr Phe Val Ile Ile Met Leu Val Val Leu Met Ser Phe Gly Val Ala Arg Gln Ala Ile Leu Phe Pro Asn Glu Glu Pro Ser Trp Lys Leu Ala Lys Asn Ile Phe Tyr Met Pro Tyr Trp Met Ile Tyr Gly Glu Val Phe Ala Asp Gln Ile Asp Arg Lys Gln Val Tyr Asp Ser His Thr Pro Lys Ser Gly Ile <210> 19 <211> 3330 <212> DNA
<213> homo sapiens <400> 19 atgtatgtgc gagtatcttttgatacaaaacctgatctcctcttacacctgatgaccaag 60 gaatggcagt tggagcttcccaagcttctcatctctgtccatgggggcctgcagaacttt 120 gaactccagc caaaactcaagcaagtctttgggaaagggctcatcaaagcagcaatgaca 180 actggagcgt ggatattcactggaggggttaacacaggtgttattcgtcatgttggcgat 240 gccttgaagg atcatgcctctaagtctcgaggaaagatatgcaccataggtattgccccc 300 tggggaattg tggaaaaccaggaggacctcattggaagagatgttgtccggccataccag 360 accatgtcca atcccatgagcaagctcactgttctcaacagcatgcattcccacttcatt 420 ctggctgaca acgggaccactggaaaatatggagcagaggtgaaacttcgaagacaactg 480 gaaaagcata tttcactccagaagataaacacaagaatcggtcaaggtgttcctgtggtg 540 gcactcatag tggaaggaggacccaatgtgatctcgattgttttggagtaccttcgagac 600 acccctcccg tgccagtggttgtctgtgatgggagtggacgggcatcggacatcctggcc 660 tttgggcata aatactcagaagaaggcggactgataaatgaatctttgagggaccagctg 720 ttggtgacta tacagaagactttcacatacactcgaacccaagctcagcatctgttcatc 780 atcctcatgg agtgcatgaagaagaaggaattgattacggtatttcggatgggatcagaa 840 ggacaccagg acattgatttggctatcctgacagctttactcaaaggagccaatgcctcg 900 gccccagacc aactgagcttagctttagcctggaacagagtcgacatcgctcgcagccag 960 atctttattt acgggcaacagtggccggtgggatctctggagcaagccatgttggatgcc 1020 ttagttctgg acagagtggattttgtgaaattactcatagagaatggagtaagcatgcac 1080 cgttttctca ccatctccagactagaggaattgtacaatacgagacatgggccctcaaat 1140 acattgtacc acttggtcagggatgtcaaaaaggggaacctgcccccagactacagaatc 1200 agcctgattg acatcggcctggtgatcgagtacctgatgggcggggcttatcgctgcaac 1260 tacacgcgca agcgcttccggaccctctaccacaacctcttcggccccaagaggcccaaa 1320 gccttgaaac tgctgggaatggaggatgatattcccttgaggcgaggaagaaagacaacc 1380 aagaaacgtg aagaagaggtggacattgacttggatgatcctgagatcaaccacttcccc 1440 ttccctttcc atgagctcatggtgtgggctgttctcatgaagcggcagaagatggccctg 1500 ttcttctggc agcacggtgaggaggccatggccaaggccctggtggcctgcaagctctgc 1560 aaagccatgg ctcatgaggcctctgagaacgacatggttgacgacatttcccaggagctg 1620 aatcacaatt ccagagactttggccagctggctgtggagctcctggaccagtcctacaag 1680 caggacgaac agctggccatgaaactgctgacgtatgagctgaagaactggagcaacgcc 1740 acgtgcctgc agcttgccgtggctgccaaacaccgcgacttcatcgcgcacacgtgcagc 1800 cagatgctgc tcaccgacatgtggatgggccggctccgcatgcgcaagaactcaggcctc 1860 aaggtaattc tgggaattctacttcctccttcaattctcagcttggagttcaagaacaaa 1920 gacgacatgccctatatgtctcaggcccaggaaatccacctccaagagaaggaggcagaa1980 gaaccagagaagcccacaaaggaaaaagaggaagaggacatggagctcacagcaatgttg2040 ggacgaaacaacggggagtcctccaggaagaaggatgaagaggaagttcagagcaagcac2100 cggttaatccccctcggcagaaaaatctatgaattctacaatgcacccatcgtgaagttc2160 tggttctacacactggcgtatatcggatacctgatgctcttcaactatatcgtgttagtg2220 aagatggaacgctggccgtccacccaggaatggatcgtaatctcctatattttcaccctg2280 ggaatagaaaagatgagagagattctgatgtcagagccagggaagttgctacagaaagtg2340 aaggtatggctgcaggagtactggaatgtcacggacctcatcgccatccttctgttttct2400 gtcggaatgatccttcgtctccaagaccagcccttcaggagtgacgggagggtcatctac2460 tgcgtgaacatcatttactggtatatccgtctcctagacatcttcggcgtgaacaagtat2520 ttgggcccgtatgtaatgatgattggaaaaatgatgatagacatgatgtactttgtcatc2580 attatgctggtggttctgatgagctttggggtcgccaggcaagccatcctttttcccaat2640 gaggagccatcatggaaactggccaagaacatcttctacatgccctattggatgatttat2700 ggggaagtgtttgcggaccagatagaccctccctgtggacagaatgagacccgagaggat2760 ggtaaaataatccagctgcctccctgcaagacaggagcttggatcgtgccggccatcatg2820 gcctgctacctcttagtggcaaacatcttgctggtcaacctcctcattgctgtctttaac2880 aatacattttttgaagtaaaatcgatatccaaccaagtctggaagtttcagaggtatcag2940 ctcatcatgactttccatgaaaggccagttctgcccccaccactgatcatcttcagccac3000 atgaccatgatattccagcacctgtgctgccgatggaggaaacacgagagcgacccggat3060 gaaagggactacggcctgaaactcttcataaccgatgatgagctcaagaaagtacatgac3120 tttgaagagcaatgcatagaagaatacttcagagaaaaggatgatcggttcaactcatct3180 aatgatgagaggatacgggtgacttcagaaaggtgtgttctgtggacacctgcctcctgc3240 agatgtgttgtgccaaggcatgctttatccatcgaatttattcacacggtcacaaaacag3300 agatcttttgtgtttgtttttattgtctga 3330 <210> 20 <211> 1109 <212> PRT
<213> homo sapiens <400> 20 Met Tyr Val Arg Val Ser Phe Asp Thr Lys Pro Asp Leu Leu Leu His Leu Met Thr Lys Glu Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser Val His Gly Gly Leu Gln Asn Phe Glu Leu Gln Pro Lys Leu Lys Gln Val Phe Gly Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp Ile Phe Thr Gly Gly Val Asn Thr Gly Val Ile Arg His Val Gly Asp Ala Leu Lys Asp His Ala Ser Lys Ser Arg Gly Lys Ile Cys Thr Ile Gly Ile Ala Pro Trp Gly Ile Val Glu Asn Gln Glu Asp Leu Ile Gly Arg Asp Val Val Arg Pro Tyr Gln Thr Met Ser Asn Pro Met Ser Lys Leu Thr Val Leu Asn Ser Met His Ser His Phe Ile Leu Ala Asp Asn Gly Thr Thr Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Gln Leu Glu Lys His Ile Ser Leu Gln Lys Ile Asn Thr Arg Ile Gly Gln Gly Val Pro Val Val Ala Leu Ile Val Glu Gly Gly Pro Asn Val Ile Ser Ile Val Leu Glu Tyr Leu Arg Asp Thr Pro Pro Val Pro Val Val Val Cys Asp Gly Ser Gly Arg Ala Ser Asp Ile Leu Ala Phe Gly His Lys Tyr Ser Glu Glu Gly Gly Leu Ile Asn Glu Ser Leu Arg Asp Gln Leu Leu Val Thr Ile Gln Lys Thr Phe Thr Tyr Thr Arg Thr Gln Ala Gln His Leu Phe Ile Ile Leu Met Glu Cys Met Lys Lys Lys Glu Leu Ile Thr Val Phe Arg Met Gly Ser Glu Gly His Gln Asp Ile Asp Leu Ala Ile Leu Thr Ala Leu Leu Lys Gly Ala Asn Ala Ser Ala Pro Asp Gln Leu Ser Leu Ala Leu Ala Trp Asn Arg Val Asp Ile Ala Arg Ser Gln Ile Phe Ile Tyr Gly Gln Gln Trp Pro Val Gly Ser Leu Glu Gln Ala Met Leu Asp Ala Leu Val Leu Asp Arg Val Asp Phe Val Lys Leu Leu Ile Glu Asn Gly Val Ser Met His Arg Phe Leu Thr Ile Ser Arg Leu Glu Glu Leu Tyr Asn Thr Arg His Gly Pro Ser Asn Thr Leu Tyr His Leu Val Arg Asp Val Lys Lys Gly Asn Leu Pro Pro Asp Tyr Arg Ile Ser Leu Ile Asp Ile Gly Leu Val Ile Glu Tyr Leu Met Gly Gly Ala Tyr Arg Cys Asn Tyr Thr Arg Lys Arg Phe Arg Thr Leu Tyr His Asn Leu Phe Gly Pro Lys Arg Pro Lys Ala Leu Lys Leu Leu Gly Met Glu Asp Asp Ile Pro Leu Arg Arg Gly Arg Lys Thr Thr Lys Lys Arg Glu Glu Glu Val Asp Ile Asp Leu Asp Asp Pro Glu Ile Asn His Phe Pro Phe Pro Phe His Glu Leu Met Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala Leu Phe Phe Trp Gln His Gly Glu Glu Ala Met Ala Lys Ala Leu Val Ala Cys Lys Leu Cys Lys Ala Met Ala His Glu Ala Ser Glu Asn Asp Met Val Asp Asp Ile Ser Gln Glu Leu Asn His Asn Ser Arg Asp Phe Gly Gln Leu Ala Val Glu Leu Leu Asp Gln Ser Tyr Lys Gln Asp Glu Gln Leu Ala Met Lys Leu Leu Thr Tyr GTu Leu Lys Asn Trp Ser Asn Ala Thr Cys Leu Gln Leu Ala Val Ala Ala Lys His Arg Asp Phe Ile Ala His Thr Cys Ser Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg Leu Arg Met Arg Lys Asn Ser Gly Leu Lys Val Ile Leu Gly Ile Leu Leu Pro Pro Ser Ile Leu Ser Leu Glu Phe Lys Asn Lys Asp Asp Met Pro Tyr Met Ser Gln Ala Gln Glu Ile His Leu Gln Glu Lys Glu Ala Glu Glu Pro Glu Lys Pro Thr Lys Glu Lys Glu Glu Glu Asp Met Glu Leu Thr Ala Met Leu Gly Arg Asn Asn Gly Glu Ser Ser Arg Lys Lys Asp Glu Glu Glu Val Gln Ser Lys His Arg Leu Ile Pro Leu Gly Arg Lys Ile Tyr Glu Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Leu Ala Tyr Ile Gly Tyr Leu Met Leu Phe Asn Tyr Ile Val Leu Val Lys Met Glu Arg Trp Pro Ser Thr Gln Glu Trp Ile Val Ile Ser Tyr Ile Phe Thr Leu Gly Ile Glu Lys Met Arg Glu Ile Leu Met Ser Glu Pro Gly Lys Leu Leu Gln Lys Val Lys Val Trp Leu Gln Glu Tyr Trp Asn Val Thr Asp Leu Ile Ala Ile Leu Leu Phe Ser Val Gly Met Ile Leu Arg Leu Gln Asp Gln Pro Phe Arg Ser Asp Gly Arg Val Ile Tyr Cys Val Asn Ile Ile Tyr Trp Tyr Ile Arg Leu Leu Asp Ile Phe Gly Val Asn Lys Tyr Leu Gly Pro Tyr Val Met Met Ile Gly Lys Met Met Ile Asp Met Met Tyr Phe Val Ile Ile Met Leu Val Val Leu Met Ser Phe Gly Val Ala Arg Gln Ala Ile Leu Phe Pro Asn Glu Glu Pro Ser Trp Lys Leu Ala Lys Asn Ile Phe Tyr Met Pro Tyr Trp Met Ile Tyr Gly Glu Val Phe Ala Asp Gln Ile Asp Pro Pro Cys Gly Gln Asn Glu Thr Arg Glu Asp Gly Lys Ile Ile Gln Leu Pro Pro Cys Lys Thr Gly Ala Trp Ile Val Pro Ala Ile Met Ala Cys Tyr Leu Leu Val Ala Asn Ile Leu Leu Val Asn Leu Leu Ile Ala Val Phe Asn Asn Thr Phe Phe Glu Val Lys Ser Ile Ser Asn Gln Val Trp Lys Phe Gln Arg Tyr Gln Leu Ile Met Thr Phe His Glu Arg Pro Val Leu Pro Pro Pro Leu Ile Ile Phe Ser His Met Thr Met Ile Phe Gln His Leu Cys Cys Arg Trp Arg Lys His Glu Ser Asp Pro Asp Glu Arg Asp Tyr Gly Leu Lys Leu Phe Ile Thr Asp Asp Glu Leu Lys Lys Val His Asp Phe Glu Glu Gln Cys Ile Glu Glu Tyr Phe Arg Glu Lys Asp Asp Arg Phe Asn Ser Ser Asn Asp Glu Arg Ile Arg Val Thr Ser Glu Arg Cys Val Leu Trp Thr Pro Ala Ser Cys Arg Cys Val Val Pro Arg His Ala Leu Ser Ile Glu Phe Ile His Thr Val Thr Lys Gln Arg Ser Phe Val Phe Val Phe Ile Val <210> 21 <211> 3519 <212> DNA
<213> homo sapiens <400>

atgtatgtgcgagtatcttttgatacaaaacctgatctcctcttacacctgatgaccaag 60 gaatggcagttggagcttcccaagcttctcatctctgtccatgggggcctgcagaacttt 120 gaactccagccaaaactcaagcaagtctttgggaaagggctcatcaaagcagcaatgaca 180 actggagcgtggatattcactggaggggttaacacaggtgttattcgtcatgttggcgat 240 gccttgaaggatcatgcctctaagtctcgaggaaagatatgcaccataggtattgccccc 300 tggggaattgtggaaaaccaggaggacctcattggaagagatgttgtccggccataccag 360 accatgtccaatcccatgagcaagctcactgttctcaacagcatgcattcccacttcatt 420 ctggctgacaacgggaccactggaaaatatggagcagaggtgaaacttcgaagacaactg 480 gaaaagcatatttcactccagaagataaacacaagaatcggtcaaggtgttcctgtggtg 540 gcactcatagtggaaggaggacccaatgtgatctcgattgttttggagtaccttcgagac 600 acccctcccgtgccagtggttgtctgtgatgggagtggacgggcatcggacatcctggcc 660 tttgggcataaatactcagaagaaggcggactgataaatgaatctttgagggaccagctg720 ttggtgactatacagaagactttcacatacactcgaacccaagctcagcatctgttcatc780 atcctcatggagtgcatgaagaagaaggaattgattacggtatttcggatgggatcagaa840 ggacaccaggacattgatttggctatcctgacagctttactcaaaggagccaatgcctcg900 gccccagaccaactgagcttagctttagcctggaacagagtcgacatcgctcgcagccag960 atctttatttacgggcaacagtggccggtgggatctctggagcaagccatgttggatgcc1020 ttagttctggacagagtggattttgtgaaattactcatagagaatggagtaagcatgcac1080 cgttttctcaccatctccagactagaggaattgtacaatacgagacatgggccctcaaat1140 acattgtaccacttggtcagggatgtcaaaaaggggaacctgcccccagactacagaatc1200 agcctgattgacatcggcctggtgatcgagtacctgatgggcggggcttatcgctgcaac1260 tacacgcgcaagcgcttccggaccctctaccacaacctcttcggccccaagaggcccaaa1320 gccttgaaactgctgggaatggaggatgatattcccttgaggcgaggaagaaagacaacc1380 aagaaacgtgaagaagaggtggacattgacttggatgatcctgagatcaaccacttcccc1440 ttccctttccatgagctcatggtgtgggctgttctcatgaagcggcagaagatggccctg1500 ttcttctggcagcacggtgaggaggccatggccaaggccctggtggcctgcaagctctgc1560 aaagccatggctcatgaggcctctgagaacgacatggttgacgacatttcccaggagctg1620 aatcacaattccagagactttggccagctggctgtggagctcctggaccagtcctacaag1680 caggacgaacagctggccatgaaactgctgacgtatgagctgaagaactggagcaacgcc1740 acgtgcctgcagcttgccgtggctgccaaacaccgcgacttcatcgcgcacacgtgcagc1800 cagatgctgctcaccgacatgtggatgggccggctccgcatgcgcaagaactcaggcctc1860 aaggtaattctgggaattctacttcctccttcaattctcagcttggagttcaagaacaaa1920 gacgacatgccctatatgtctcaggcccaggaaatccacctccaagagaaggaggcagaa1980 gaaccagagaagcccacaaaggaaaaagaggaagaggacatggagctcacagcaatgttg2040 ggacgaaacaacggggagtcctccaggaagaaggatgaagaggaagttcagagcaagcac2100 cggttaatccccctcggcagaaaaatctatgaattctacaatgcacccatcgtgaagttc2160 tggttctacacactggcgtatatcggatacctgatgctcttcaactatatcgtgttagtg2220 aagatggaacgctggccgtccacccaggaatggatcgtaatctcctatattttcaccctg2280 ggaatagaaaagatgagagagattctgatgtcagagccagggaagttgctacagaaagtg2340 aaggtatggctgcaggagtactggaatgtcacggacctcatcgccatccttctgttttct2400 gtcggaatgatccttcgtctccaagaccagcccttcaggagtgacgggagggtcatctac2460 tgcgtgaacatcatttactggtatatccgtctcctagacatcttcggcgtgaacaagtat2520 ttgggcccgtatgtaatgatgattggaaaaatgatgatagacatgatgtactttgtcatc2580 attatgctggtggttctgatgagctttggggtcgccaggcaagccatcctttttcccaat2640 gaggagccatcatggaaactggccaagaacatcttctacatgccctattggatgatttat2700 ggggaagtgtttgcggaccagatagaccctccctgtggacagaatgagacccgagaggat2760 ggtaaaataatccagctgcctccctgcaagacaggagcttggatcgtgccggccatcatg2820 gcctgctacctcttagtggcaaacatcttgctggtcaacctcctcattgctgtctttaac2880 aatacattttttgaagtaaaatcgatatccaaccaagtctggaagtttcagaggtatcag2940 ctcatcatgactttccatgaaaggccagttctgcccccaccactgatcatcttcagccac3000 atgaccatgatattccagcacctgtgctgccgatggaggaaacacgagagcgacccggat3060 gaaagggactacggcctgaaactcttcataaccgatgatgagctcaagaaagtacatgac3120 tttgaagagcaatgcatagaagaatacttcagagaaaaggatgatcggttcaactcatct3180 aatgatgagaggatacgggtgacttcagaaagggtggagaacatgtctatgcggctggag3240 gaagtcaacgagagagagcactccatgaaggcttcactccagaccgtggacatccggctg3300 gcgcagctggaagaccttatcgggcgcatggccacggccctggagcgcctgacaggtctg3360 gagcgggccgagtccaacaaaatccgctcgaggacctcgtcagactgcacggacgccgcc3420 tacattgtccgtcagagcagcttcaacagccaggaagggaacaccttcaagctccaagag3480 agtatagaccctgcagagcatcctctttattcagtataa 3519 <210> 22 <211> 1172 <212> PRT
<213> homo sapiens <400> 22 Met Tyr Val Arg Val Ser Phe Asp Thr Lys Pro Asp Leu Leu Leu His Leu Met Thr Lys Glu Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser Val His Gly Gly Leu Gln Asn Phe Glu Leu Gln Pro Lys Leu Lys Gln Val Phe Gly Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp Ile Phe Thr Gly Gly Val Asn Thr Gly Val Ile Arg His Val Gly Asp Ala Leu Lys Asp His Ala Ser Lys Ser Arg Gly Lys Ile Cys Thr Ile Gly Ile Ala Pro Trp Gly Ile Val Glu Asn Gln Glu Asp Leu Ile Gly Arg Asp Val Val Arg Pro Tyr Gln Thr Met Ser Asn Pro Met Ser Lys Leu Thr Val Leu Asn Ser Met His Ser His Phe Ile Leu Ala Asp Asn Gly Thr Thr Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Gln Leu Glu Lys His Ile Ser Leu Gln Lys Ile Asn Thr Arg Ile Gly Gln Gly Val Pro Val Val Ala Leu Ile Val Glu Gly Gly Pro Asn Val Ile Ser Ile Val Leu Glu Tyr Leu Arg Asp Thr Pro Pro Val Pro Val Val Val Cys Asp Gly Ser Gly Arg Ala Ser Asp Ile Leu Ala Phe Gly His Lys Tyr Ser Glu Glu Gly Gly Leu Ile Asn Glu Ser Leu Arg Asp Gln Leu Leu Val Thr Ile Gln Lys Thr Phe Thr Tyr Thr Arg Thr Gln Ala Gln His Leu Phe Ile Ile Leu Met Glu Cys Met Lys Lys Lys Glu Leu Ile Thr Val Phe Arg Met Gly Ser Glu Gly His Gln Asp Ile Asp Leu Ala Ile Leu Thr Ala Leu Leu Lys Gly Ala Asn Ala Ser Ala Pro Asp Gln Leu Ser Leu Ala Leu Ala Trp Asn Arg Val Asp Ile Ala Arg Ser Gln Ile Phe Ile Tyr Gly Gln Gln Trp Pro Val Gly Ser Leu Glu Gln Ala Met Leu Asp Ala Leu Val Leu Asp Arg Val Asp Phe Val Lys Leu Leu Ile Glu Asn Gly Val Ser Met His Arg Phe Leu Thr Ile Ser Arg Leu Glu Glu Leu Tyr Asn Thr Arg His Gly Pro Ser Asn Thr Leu Tyr His Leu Val Arg Asp Val Lys Lys Gly Asn Leu Pro Pro Asp Tyr Arg Ile Ser Leu Ile Asp Ile Gly Leu Val Ile Glu Tyr Leu Met Gly Gly Ala Tyr Arg Cys Asn Tyr Thr Arg Lys Arg Phe Arg Thr Leu Tyr His Asn Leu Phe Gly Pro Lys Arg Pro Lys Ala Leu Lys Leu Leu Gly Met Glu Asp Asp Ile Pro Leu Arg Arg Gly Arg Lys Thr Thr Lys Lys Arg Glu Glu Glu Val Asp Ile Asp Leu Asp Asp Pro Glu Ile Asn His Phe Pro Phe Pro Phe His Glu Leu Met Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala Leu Phe Phe Trp Gln His Gly Glu Glu Ala Met Ala Lys Ala Leu Val Ala Cys Lys Leu Cys Lys Ala Met Ala His Glu Ala Ser Glu Asn Asp Met Val Asp Asp Ile Ser Gln Glu Leu Asn His Asn Ser Arg Asp Phe Gly Gln Leu Ala Val Glu Leu Leu Asp Gln Ser Tyr Lys Gln Asp Glu Gln Leu Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ala Thr Cys Leu Gln Leu Ala Val Ala Ala Lys His Arg Asp Phe Ile Ala His Thr Cys Ser Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg Leu Arg Met Arg Lys Asn Ser Gly Leu Lys Val Ile Leu Gly Ile Leu Leu Pro Pro Ser Ile Leu Ser Leu Glu Phe Lys Asn Lys Asp Asp Met Pro Tyr Met Ser Gln Ala Gln Glu Ile His Leu Gln Glu Lys Glu Ala Glu Glu Pro Glu Lys Pro Thr Lys Glu Lys Glu Glu Glu Asp Met Glu Leu Thr Ala Met Leu Gly Arg Asn Asn Gly Glu Ser Ser Arg Lys Lys Asp Glu Glu Glu Val Gln Ser Lys His Arg Leu Ile Pro Leu Gly Arg Lys Ile Tyr Glu Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Leu Ala Tyr Ile Gly Tyr Leu Met Leu Phe Asn Tyr Ile Val Leu Val Lys Met Glu Arg Trp Pro Ser Thr Gln Glu Trp Ile Val Ile Ser Tyr Ile Phe Thr Leu Gly Ile Glu Lys Met Arg Glu Ile Leu Met Ser Glu Pro Gly Lys Leu Leu Gln Lys Val Lys Val Trp Leu Gln Glu Tyr Trp Asn Val Thr Asp Leu Ile Ala Ile Leu Leu Phe Ser Val Gly Met Ile Leu Arg Leu Gln Asp Gln Pro Phe Arg Ser Asp Gly Arg Val Ile Tyr Cys Val Asn Ile Ile Tyr Trp Tyr Ile Arg Leu Leu Asp Ile Phe Gly Val Asn Lys Tyr Leu Gly Pro Tyr Val Met Met Ile Gly Lys Met Met Ile Asp Met Met Tyr Phe Val Ile Ile Met Leu Val Val Leu Met Ser Phe Gly Val Ala Arg Gln Ala Ile Leu Phe Pro Asn Glu Glu Pro Ser Trp Lys Leu Ala Lys Asn Ile Phe Tyr Met Pro Tyr Trp Met Ile Tyr Gly Glu Val Phe Ala Asp Gln Ile Asp Pro Pro Cys Gly Gln Asn Glu Thr Arg Glu Asp Gly Lys Ile Ile Gln Leu Pro Pro Cys Lys Thr Gly Ala Trp Ile Val Pro Ala Ile Met Ala Cys Tyr Leu Leu Val Ala Asn Ile Leu Leu Val Asn Leu Leu Ile Ala Val Phe Asn Asn Thr Phe Phe Glu Val Lys Ser Ile Ser Asn Gln Val Trp Lys Phe Gln Arg Tyr Gln Leu Ile Met Thr Phe His Glu Arg Pro Val Leu Pro Pro Pro Leu Ile Ile Phe Ser His Met Thr Met Ile Phe Gln His Leu Cys Cys Arg Trp Arg Lys His Glu Ser Asp Pro Asp Glu Arg Asp Tyr Gly Leu Lys Leu Phe Ile Thr Asp Asp Glu Leu Lys Lys Val His Asp Phe Glu Glu Gln Cys Ile Glu Glu Tyr Phe Arg Glu Lys Asp Asp Arg Phe Asn Ser Ser Asn Asp Glu Arg Ile Arg Val Thr Ser Glu Arg Val Glu Asn Met Ser Met Arg Leu Glu Glu Val Asn Glu Arg Glu His Ser Met Lys Ala Ser Leu Gln Thr Val Asp Ile Arg Leu Ala Gln Leu Glu Asp Leu Ile Gly Arg Met Ala Thr Ala Leu Glu Arg Leu Thr Gly Leu Glu Arg Ala Glu Ser Asn Lys Ile Arg Ser Arg Thr Ser Ser Asp Cys Thr Asp Ala Ala Tyr Ile Val Arg Gln Ser Ser Phe Asn Ser Gln Glu Gly Asn Thr Phe Lys Leu Gln Glu Ser Ile Asp Pro Ala Glu His Pro Leu Tyr Ser Val <210> 23 <211> 4665 <212> DNA
<213> homo sapiens <400> 23 atgtatgtgcgagtatcttttgatacaaaacctgatctcctcttacacctgatgaccaag60 gaatggcagttggagcttcccaagcttctcatctctgtccatgggggcctgcagaacttt120 gaactccagccaaaactcaagcaagtctttgggaaagggctcatcaaagcagcaatgaca180 actggagcgtggatattcactggaggggttaacacaggtgttattcgtcatgttggcgat240 gccttgaaggatcatgcctctaagtctcgaggaaagatatgcaccataggtattgccccc300 tggggaattgtggaaaaccaggaggacctcattggaagagatgttgtccggccataccag360 accatgtccaatcccatgagcaagctcactgttctcaacagcatgcattcccacttcatt420 ctggctgacaacgggaccactggaaaatatggagcagaggtgaaacttcgaagacaactg480 gaaaagcatatttcactccagaagataaacacaagaatcggtcaaggtgttcctgtggtg540 gcactcatagtggaaggaggacccaatgtgatctcgattgttttggagtaccttcgagac600 acccctcccgtgccagtggttgtctgtgatgggagtggacgggcatcggacatcctggcc660 tttgggcataaatactcagaagaaggcggactgataaatgaatctttgagggaccagctg720 ttggtgactatacagaagactttcacatacactcgaacccaagctcagcatctgttcatc780 atcctcatggagtgcatgaagaagaaggaattgattacggtatttcggatgggatcagaa840 ggacaccaggacattgatttggctatcctgacagctttactcaaaggagccaatgcctcg900 gccccagaccaactgagcttagctttagcctggaacagagtcgacatcgctcgcagccag960 atctttatttacgggcaacagtggccggtgggatctctggagcaagccatgttggatgcc1020 ttagttctggacagagtggattttgtgaaattactcatagagaatggagtaagcatgcac1080 cgttttctcaccatctccagactagaggaattgtacaatacgagacatgggccctcaaat1140 acattgtaccacttggtcagggatgtcaaaaaggggaacctgcccccagactacagaatc1200 agcctgattgacatcggcctggtgatcgagtacctgatgggcggggcttatcgctgcaac1260 tacacgcgcaagcgcttccggaccctctaccacaacctcttcggccccaagaggcccaaa1320 gccttgaaactgctgggaatggaggatgatattcccttgaggcgaggaagaaagacaacc1380 aagaaacgtgaagaagaggtggacattgacttggatgatcctgagatcaaccacttcccc1440 ttccctttccatgagctcatggtgtgggctgttctcatgaagcggcagaagatggccctg1500 ttcttctggcagcacggtgaggaggccatggccaaggccctggtggcctgcaagctctgc1560 aaagccatggctcatgaggcctctgagaacgacatggttgacgacatttcccaggagctg1620 aatcacaattccagagactttggccagctggctgtggagctcctggaccagtcctacaag1680 caggacgaacagctggccatgaaactgctgacgtatgagctgaagaactggagcaacgcc1740 acgtgcctgcagcttgccgtggctgccaaacaccgcgacttcatcgcgcacacgtgcagc1800 cagatgctgctcaccgacatgtggatgggccggctccgcatgcgcaagaactcaggcctc1860 aaggtaattctgggaattctacttcctccttcaattctcagcttggagttcaagaacaaa1920 gacgacatgccctatatgtctcaggcccaggaaatccacctccaagagaaggaggcagaa1980 gaaccagagaagcccacaaaggaaaaagaggaagaggacatggagctcacagcaatgttg2040 ggacgaaacaacggggagtcctccaggaagaaggatgaagaggaagttcagagcaagcac2100 cggttaatccccctcggcagaaaaatctatgaattctacaatgcacccatcgtgaagttc2160 tggttctacacactggcgtatatcggatacctgatgctcttcaactatatcgtgttagtg2220 aagatggaacgctggccgtccacccaggaatggatcgtaatctcctatattttcaccctg2280 ggaatagaaaagatgagagagattctgatgtcagagccagggaagttgctacagaaagtg2340 aaggtatggctgcaggagtactggaatgtcacggacctcatcgccatccttctgttttct2400 gtcggaatgatccttcgtctccaagaccagcccttcaggagtgacgggagggtcatctac2460 tgcgtgaacatcatttactggtatatccgtctcctagacatcttcggcgtgaacaagtat2520 ttgggcccgtatgtaatgatgattggaaaaatgatgatagacatgatgtactttgtcatc 2580 attatgctggtggttctgatgagctttggggtcgccaggcaagccatcctttttcccaat 2640 gaggagccatcatggaaactggccaagaacatcttctacatgccctattggatgatttat 2700 ggggaagtgtttgcggaccagatagaccctccctgtggacagaatgagacccgagaggat 2760 ggtaaaataatccagctgcctccctgcaagacaggagcttggatcgtgccggccatcatg 2820 gcctgctacctcttagtggcaaacatcttgctggtcaacctcctcattgctgtctttaac 2880 aatacattttttgaagtaaaatcgatatccaaccaagtctggaagtttcagaggtatcag 2940 ctcatcatgactttccatgaaaggccagttctgcccccaccactgatcatcttcagccac 3000 atgaccatgatattccagcacctgtgctgccgatggaggaaacacgagagcgacccggat 3060 gaaagggactacggcctgaaactcttcataaccgatgatgagctcaagaaagtacatgac 3120 tttgaagagcaatgcatagaagaatacttcagagaaaaggatgatcggttcaactcatct 3180 aatgatgagaggatacgggtgacttcagaaagggtggagaacatgtctatgcggctggag 3240 gaagtcaacgagagagagcactccatgaaggcttcactccagaccgtggacatccggctg 3300 gcgcagctggaagaccttatcgggcgcatggccacggccctggagcgcctgacaggtctg 3360 gagcgggccgagtccaacaaaatccgctcgaggacctcgtcagactgcacggacgccgcc 3420 tacattgtccgtcagagcagcttcaacagccaggaagggaacaccttcaagctccaagag 3480 agtatagaccctgcaggtgaggagaccatgtccccaacttctccaaccttaatgccccgt 3540 atgcgaagccattctttctattcggtcaatatgaaagacaaaggtggtatagaaaagttg 3600 gaaagtatttttaaagaaaggtccctgagcctacaccgggctactagttcccactctgta 3660 gcaaaagaacccaaagctcctgcagcccctgccaacaccttggccattgttcctgattcc 3720 agaagaccatcatcgtgtatagacatctatgtctctgctatggatgagctccactgtgat 3780 atagaccctctggacaattccgtgaacatccttgggctaggcgagccaagcttttcaact 3840 ccagtaccttccacagccccttcaagtagtgcctatgcaacacttgcacccacagacaga 3900 cctccaagccggagcattgattttgaggacatcacctccatggacactagatctttttct 3960 tcagactacacccacctcccagaatgccaaaacccctgggactcagagcctccgatgtac 4020 cacaccattgagcgttccaaaagtagccgctacctagccaccacaccctttcttctagaa 4080 gaggctcccattgtgaaatctcatagctttatgttttccccctcaaggagctattatgcc 4140 aactttggggtgcctgtaaaaacagcagaatacacaagtattacagactgtattgacaca 4200 aggtgtgtcaatgcccctcaagcaattgcggacagagctgccttccctggaggtcttgga 4260 gacaaagtggaggacttaacttgctgccatccagagcgagaagcagaactgagtcacccc 4320 agctctgacagtgaggagaatgaggccaaaggccgcagagccaccattgcaatatcctcc 4380 caggagggtgataactcagagagaaccctgtccaacaacatcactgttcccaagatagag 4440 cgcgccaacagctactcggcagaggagccaagtgcgccatatgcacacaccaggaagagc 4500 ttctccatcagtgacaaactcgacaggcagcggaacacagcaagcctgcgaaatcccttc 4560 cagagaagcaagtcctccaagccggagggccgaggggacagcctgtccatgaggaaactg 4620 tccagaacatcggctttccaaagctttgaaagcaagcacacctaa 4665 <210> 24 <211> 1554 <212> PRT
<213> homo sapiens <400> 24 Met Tyr Val Arg Val Ser Phe Asp Thr Lys Pro Asp Leu Leu Leu His Leu Met Thr Lys Glu Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser Val His Gly Gly Leu Gln Asn Phe Glu Leu Gln Pro Lys Leu Lys Gln Val Phe Gly Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp Ile Phe Thr Gly Gly Val Asn Thr Gly Val Ile Arg His Val Gly Asp Ala Leu Lys Asp His Ala Ser Lys Ser Arg Gly Lys Ile Cys Thr Ile Gly Ile Ala Pro Trp Gly Ile Val Glu Asn Gln Glu Asp Leu Ile Gly Arg Asp Val Val Arg Pro Tyr Gln Thr Met Ser Asn Pro Met Ser Lys Leu Thr Val Leu Asn Ser Met His Ser His Phe Ile Leu Ala Asp Asn Gly Thr Thr Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Gln Leu Glu Lys His Ile Ser Leu Gln Lys Ile Asn Thr Arg Ile Gly Gln Gly Val Pro Val Val Ala Leu Ile Val Glu Gly Gly Pro Asn Val Ile Ser Ile Val Leu Glu Tyr Leu Arg Asp Thr Pro Pro Val Pro Val Val Val Cys Asp Gly Ser Gly Arg Ala Ser Asp Ile Leu Ala Phe Gly His Lys Tyr Ser Glu Glu Gly Gly Leu Ile Asn Glu Ser Leu Arg Asp Gln Leu Leu Val Thr Ile Gln Lys Thr Phe Thr Tyr Thr Arg Thr Gln Ala Gln His Leu Phe Ile Ile Leu Met Glu Cys Met Lys Lys Lys Glu Leu Ile Thr Val Phe Arg Met Gly Ser Glu Gly His Gln Asp Ile Asp Leu Ala Ile Leu Thr Ala Leu Leu Lys Gly Ala Asn Ala Ser Ala Pro Asp Gln Leu Ser Leu Ala Leu Ala Trp Asn Arg Val Asp Ile Ala Arg Ser Gln Ile Phe Ile Tyr Gly Gln Gln Trp Pro Val Gly Ser Leu Glu Gln Ala Met Leu Asp Ala Leu Val Leu Asp Arg Val Asp Phe Val Lys Leu Leu Ile Glu Asn Gly Val Ser Met His Arg Phe Leu Thr Ile Ser Arg Leu Glu Glu Leu Tyr Asn Thr Arg His Gly Pro Ser Asn Thr Leu Tyr His Leu Val Arg Asp Val Lys Lys Gly Asn Leu Pro Pro Asp Tyr Arg Ile Ser Leu Ile Asp Ile Gly Leu Val Ile Glu Tyr Leu Met Gly Gly Ala Tyr Arg Cys Asn Tyr Thr Arg Lys Arg Phe Arg Thr Leu Tyr His Asn Leu Phe Gly Pro Lys Arg Pro Lys Ala Leu Lys Leu Leu Gly Met Glu Asp Asp Ile Pro Leu Arg Arg Gly Arg Lys Thr Thr Lys Lys Arg Glu Glu Glu Val Asp Ile Asp Leu Asp Asp Pro Glu Ile Asn His Phe Pro Phe Pro Phe His Glu Leu Met Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala Leu Phe Phe Trp Gln His Gly Glu Glu Ala Met Ala Lys Ala Leu Val Ala Cys Lys Leu Cys Lys Ala Met Ala His Glu Ala Ser Glu Asn Asp Met Val Asp Asp Ile Ser Gln Glu Leu Asn His Asn Ser Arg Asp Phe Gly Gln Leu Ala Val Glu Leu Leu Asp Gln Ser Tyr Lys Gln Asp Glu Gln Leu Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ala Thr Cys Leu Gln Leu Ala Val Ala Ala Lys His Arg Asp Phe Ile Ala His Thr Cys Ser Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg Leu Arg Met Arg Lys Asn Ser Gly Leu Lys Val Ile Leu Gly Ile Leu Leu Pro Pro Ser Ile Leu Ser Leu Glu Phe Lys Asn Lys Asp Asp Met Pro Tyr Met Ser Gln Ala Gln Glu Ile His Leu Gln Glu Lys Glu Ala Glu Glu Pro Glu Lys Pro Thr Lys Glu Lys Glu Glu Glu Asp Met Glu Leu Thr Ala Met Leu Gly Arg Asn Asn Gly Glu Ser Ser Arg Lys Lys Asp Glu Glu Glu Val Gln Ser Lys His Arg Leu Ile Pro Leu Gly Arg Lys Ile Tyr Glu Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Leu Ala Tyr Ile Gly Tyr Leu Met Leu Phe Asn Tyr Ile Val Leu Val Lys Met Glu Arg Trp Pro Ser Thr Gln Glu Trp Ile Val Ile Ser Tyr Ile Phe Thr Leu Gly Ile Glu Lys Met Arg Glu Ile Leu Met Ser Glu Pro Gly Lys Leu Leu Gln Lys Val Lys Val Trp Leu Gln Glu Tyr Trp Asn Val Thr Asp Leu Ile Ala Ile Leu Leu Phe Ser Val Gly Met Ile Leu Arg Leu Gln Asp Gln Pro Phe Arg Ser Asp Gly Arg Val Ile Tyr Cys Val Asn Ile Ile Tyr Trp Tyr Ile Arg Leu Leu Asp Ile Phe Gly Val Asn Lys Tyr Leu Gly Pro Tyr Val Met Met Ile Gly Lys Met Met Ile Asp Met Met Tyr Phe Val Ile Ile Met Leu Val Val Leu Met Ser Phe Gly Val Ala Arg Gln Ala Ile Leu Phe Pro Asn Glu Glu Pro Ser Trp Lys Leu Ala Lys Asn Ile Phe Tyr Met Pro Tyr Trp Met Ile Tyr Gly Glu Val Phe Ala Asp Gln Ile Asp Pro Pro Cys Gly Gln Asn Glu Thr Arg Glu Asp Gly Lys Ile Ile Gln Leu Pro Pro Cys Lys Thr Gly Ala Trp Ile Val Pro Ala Ile Met Ala Cys Tyr Leu Leu Val Ala Asn Ile Leu Leu Val Asn Leu Leu Ile Ala Val Phe Asn Asn Thr Phe Phe Glu Val Lys Ser Ile Ser Asn Gln Val Trp Lys Phe Gln Arg Tyr Gln Leu Ile Met Thr Phe His Glu Arg Pro Val Leu Pro Pro Pro Leu Ile Ile Phe Ser His Met Thr Met Ile Phe Gln His Leu Cys Cys Arg Trp Arg Lys His Glu Ser Asp Pro Asp Glu Arg Asp Tyr Gly Leu Lys Leu Phe Ile Thr Asp Asp Glu Leu Lys Lys Val His Asp Phe Glu Glu Gln Cys Ile Glu Glu Tyr Phe Arg Glu Lys Asp Asp Arg Phe Asn Ser Ser Asn Asp Glu Arg Ile Arg Val Thr Ser Glu Arg Val Glu Asn Met Ser Met Arg Leu Glu Glu Val Asn Glu Arg Glu His Ser Met Lys Ala Ser Leu Gln Thr Val Asp Ile Arg Leu Ala Gln Leu Glu Asp Leu Ile Gly Arg Met Ala Thr Ala Leu Glu Arg Leu Thr Gly Leu Glu Arg Ala Glu Ser Asn Lys Ile Arg Ser Arg Thr Ser Ser Asp Cys Thr Asp Ala Ala Tyr Ile Val Arg Gln Ser Ser Phe Asn Ser Gln Glu Gly Asn Thr Phe Lys Leu Gln Glu Ser Ile Asp Pro Ala Gly Glu Glu Thr Met Ser Pro Thr Ser Pro Thr Leu Met Pro Arg Met Arg Ser His Ser Phe Tyr Ser Val Asn Met Lys Asp Lys Gly Gly Ile Glu Lys Leu Glu Ser Ile Phe Lys Glu Arg Ser Leu Ser Leu His Arg Ala Thr Ser Ser His Ser Val Ala Lys Glu Pro Lys Ala Pro Ala Ala Pro Ala Asn Thr Leu Ala Ile Val Pro Asp Ser Arg Arg Pro Ser Ser Cys Ile Asp Ile Tyr Val Ser Ala Met Asp Glu Leu His Cys Asp Ile Asp Pro Leu Asp Asn Ser Val Asn Ile Leu Gly Leu Gly Glu Pro Ser Phe Ser Thr Pro Val Pro Ser Thr Ala Pro Ser Ser Ser Ala Tyr Ala Thr Leu Ala Pro Thr Asp Arg Pro Pro Ser Arg Ser Ile Asp Phe Glu Asp Ile Thr Ser Met Asp Thr Arg Ser Phe Ser Ser Asp Tyr Thr His Leu Pro Glu Cys Gln Asn Pro Trp Asp Ser Glu Pro Pro Met Tyr His Thr Ile Glu Arg Ser Lys Ser Ser Arg Tyr Leu Ala Thr Thr Pro Phe Leu Leu Glu Glu Ala Pro Ile Val Lys Ser His Ser Phe Met Phe Ser Pro Ser Arg Ser Tyr Tyr Ala Asn Phe Gly Val Pro Val Lys Thr Ala Glu Tyr Thr Ser Ile Thr Asp Cys Ile Asp Thr Arg Cys Val Asn Ala Pro Gln Ala Ile Ala Asp Arg Ala Ala Phe Pro Gly Gly Leu Gly Asp Lys Val Glu Asp Leu Thr Cys Cys His Pro Glu Arg Glu Ala Glu Leu Ser His Pro Ser Ser Asp Ser Glu Glu Asn Glu Ala Lys Gly Arg Arg Ala Thr Ile Ala Ile Ser Ser Gln Glu Gly Asp Asn Ser Glu Arg Thr Leu Ser Asn Asn Ile Thr Val Pro Lys Ile Glu Arg Ala Asn Ser Tyr Ser Ala Glu Glu Pro Ser Ala Pro Tyr Ala His Thr Arg Lys Ser Phe Ser Ile Ser Asp Lys Leu Asp Arg Gln Arg Asn Thr Ala Ser Leu Arg Asn Pro Phe Gln Arg Ser Lys Ser Ser Lys Pro Glu Gly Arg Gly Asp Ser Leu Ser Met Arg Lys Leu Ser Arg Thr Ser Ala Phe Gln Ser Phe Glu Ser Lys His Thr <210> 25 <211> 2382 <212> DNA
<213> homo sapiens <400> 25 atgtatgtgc gagtatcttt tgatacaaaa cctgatctcc tcttacacct gatgaccaag 60 gaatggcagt tggagcttcc caagcttctc atctctgtcc atgggggcct gcagaacttt 120 gaactccagc caaaactcaa gcaagtcttt gggaaagggc tcatcaaagc agcaatgaca 180 actggagcgt ggatattcac tggaggggtt aacacaggtg ttattcgtca tgttggcgat 240 gccttgaagg atcatgcctc taagtctcga ggaaagatat gcaccatagg tattgccccc 300 tggggaattg tggaaaacca ggaggacctc attggaagag atgttgtccg gccataccag 360 accatgtccaatcccatgagcaagctcactgttctcaacagcatgcattcccacttcatt 420 ctggctgacaacgggaccactggaaaatatggagcagaggtgaaacttcgaagacaactg 480 gaaaagcatatttcactccagaagataaacacaagatgcctgccgtttttctctcttgac 540 tcccgcttgttttattcattttggggtagttgccagttagactcagttggaatcggtcaa 600 ggtgttcctgtggtggcactcatagtggaaggaggacccaatgtgatctcgattgttttg 660 gagtaccttcgagacacccctcccgtgccagtggttgtctgtgatgggagtggacgggca 720 tcggacatcctggcctttgggcataaatactcagaagaaggcggactgataaatgaatct 780 ttgagggaccagctgttggtgactatacagaagactttcaCatacactcgaacccaagct 840 cagcatctgttcatcatcctcatggagtgcatgaagaagaaggaattgattacggtattt 900 cggatgggatcagaaggacaccaggacattgatttggctatcctgacagctttactcaaa 960 ggagccaatgcctcggccccagaccaactgagcttagctttagcctggaacagagtcgac 1020 atcgctcgcagccagatctttatttacgggcaacagtggccggtgggatctctggagcaa 1080 gccatgttggatgccttagttctggacagagtggattttgtgaaattactcatagagaat 1140 ggagtaagcatgcaccgttttctcaccatctccagactagaggaattgtacaatacgaga 1200 catgggccctcaaatacattgtaccacttggtcagggatgtcaaaaaggggaacctgccc 1260 ccagactacagaatcagcctgattgacatcggcctggtgatcgagtacctgatgggcggg 1320 gcttatcgctgcaactacacgcgcaagcgcttccggaccctctaccacaacctcttcggc 1380 cccaagagggatgatattcccttgaggcgaggaagaaagacaaccaagaaacgtgaagaa 1440 gaggtggacattgacttggatgatcctgagatcaaccacttccccttccctttccatgag 1500 ctcatggtgtgggctgttctcatgaagcggcagaagatggccctgttcttctggcagcac 1560 ggtgaggaggccatggccaaggccctggtggcctgcaagctctgcaaagccatggctcat 1620 gaggcctctgagaacgacatggttgacgacatttcccaggagctgaatcacaattccaga 1680 gactttggccagctggctgtggagctcctggaccagtcctacaagcaggacgaacagctg 1740 gccatgaaactgctgacgtatgagctgaagaactggagcaacgccacgtgcctgcagctt 1800 gccgtggctgccaaacaccgcgacttcatcgcgcacacgtgcagccagatgctgctcacc 1860 gacatgtggatgggccggctccgcatgcgcaagaactcaggcctcaaggtaattctggga 1920 attctacttcctccttcaattctcagcttggagttcaagaacaaagacgacatgccctat 1980 atgtctcaggcccaggaaatccacctccaagagaaggaggcagaagaaccagagaagccc 2040 acaaaggaaaaagaggaagaggacatggagctcacagcaatgttgggacgaaacaacggg 2100 gagtcctccaggaagaaggatgaagaggaagttcagagcaagcaccggttaatccccctc 2160 ggcagaaaaatctatgaattctacaatgcacccatcgtgaagttctggttctacacactg 2220 gcgtatatcggatacctgatgctcttcaactatatcgtgttagtgaagatggaacgctgg 2280 ccgtccacccaggaatggatcgtaatctcctatattttcacccttgttccagctggttgt 2340 ctgcacttcggtcttcccattcatggtgccttttcttcttga 2382 <210> 26 <211> 793 <212> PRT
<213> homo sapiens <400> 26 Met Tyr Val Arg Val Ser Phe Asp Thr Lys Pro Asp Leu Leu Leu His Leu Met Thr Lys Glu Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser Val His Gly Gly Leu Gln Asn Phe Glu Leu Gln Pro Lys Leu Lys Gln Val Phe Gly Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp Ile Phe Thr Gly Gly Val Asn Thr Gly Val Ile Arg His Val Gly Asp Ala Leu Lys Asp His Ala Ser Lys Ser Arg Gly Lys Ile Cys Thr Ile Gly Ile Ala Pro Trp Gly Ile Val Glu Asn Gln Glu Asp Leu Ile Gly Arg Asp Val Val Arg Pro Tyr Gln Thr Met Ser Asn Pro Met Ser Lys Leu Thr Val Leu Asn Ser Met His Ser His Phe Ile Leu Ala Asp Asn Gly Thr Thr Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Gln Leu Glu Lys His Ile Ser Leu Gln Lys Ile Asn Thr Arg Cys Leu Pro Phe Phe Ser Leu Asp Ser Arg Leu Phe Tyr Ser Phe Trp Gly Ser Cys Gln Leu Asp Ser Val Gly Ile Gly Gln Gly Val Pro Val Val Ala Leu Ile Val Glu Gly Gly Pro Asn Val Ile Ser Ile Val Leu Glu Tyr Leu Arg Asp Thr Pro Pro Val Pro Val Val Val Cys Asp Gly Ser Gly Arg Ala Ser Asp Ile Leu Ala Phe Gly His Lys Tyr Ser Glu Glu Gly Gly Leu Ile Asn Glu Ser Leu Arg Asp Gln Leu Leu Val Thr Ile Gln Lys Thr Phe Thr Tyr Thr Arg Thr Gln Ala Gln His Leu Phe Ile Ile Leu Met Glu Cys Met Lys Lys Lys Glu Leu Ile Thr Val Phe Arg Met Gly Ser Glu Gly His Gln Asp Ile Asp Leu Ala Ile Leu Thr Ala Leu Leu Lys Gly Ala Asn Ala Ser Ala Pro Asp Gln Leu Ser Leu Ala Leu Ala Trp Asn Arg Val Asp Ile Ala Arg Ser Gln Ile Phe Ile Tyr Gly Gln Gln Trp Pro Val Gly Ser Leu Glu Gln Ala Met Leu Asp Ala Leu Val Leu Asp Arg Val Asp Phe Val Lys Leu Leu Ile Glu Asn Gly Val Ser Met His Arg Phe Leu Thr Ile Ser Arg Leu Glu Glu Leu Tyr Asn Thr Arg His Gly Pro Ser Asn Thr Leu Tyr His Leu Val Arg Asp Val Lys Lys Gly Asn Leu Pro Pro Asp Tyr Arg Ile Ser Leu Ile Asp Ile Gly Leu Val Ile Glu Tyr Leu Met Gly Gly Ala Tyr Arg Cys Asn Tyr Thr Arg Lys Arg Phe Arg Thr Leu Tyr His Asn Leu Phe Gly Pro Lys Arg Asp Asp Ile Pro Leu Arg Arg Gly Arg Lys Thr Thr Lys Lys Arg Glu Glu Glu Val Asp Ile Asp Leu Asp Asp Pro Glu Ile Asn His Phe Pro Phe Pro Phe His Glu Leu Met Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala Leu Phe Phe Trp Gln His Gly Glu Glu Ala Met Ala Lys Ala Leu Val Ala Cys Lys Leu Cys Lys Ala Met Ala His Glu Ala Ser Glu Asn Asp Met Val Asp Asp Ile Ser Gln Glu Leu Asn His Asn Ser Arg Asp Phe Gly Gln Leu Ala Val Glu Leu Leu Asp Gln Ser Tyr Lys Gln Asp Glu Gln Leu Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ala Thr Cys Leu Gln Leu Ala Val Ala Ala Lys His Arg Asp Phe Ile Ala His Thr Cys Ser Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg Leu Arg Met Arg Lys Asn Ser Gly Leu Lys Val Ile Leu Gly Ile Leu Leu Pro Pro Ser Ile Leu Ser Leu Glu Phe Lys Asn Lys Asp Asp Met Pro Tyr Met Ser Gln Ala Gln Glu Ile His Leu Gln Glu Lys Glu Ala Glu Glu Pro Glu Lys Pro Thr Lys Glu Lys Glu Glu Glu Asp Met Glu Leu Thr Ala Met Leu Gly Arg Asn Asn Gly Glu Ser Ser Arg Lys Lys Asp Glu Glu Glu Val Gln Ser Lys His Arg Leu Ile Pro Leu Gly Arg Lys Ile Tyr Glu Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Leu Ala Tyr Ile Gly Tyr Leu Met Leu Phe Asn Tyr Ile Val Leu Val Lys Met Glu Arg Trp Pro Ser Thr Gln Glu Trp Ile Val Ile Ser Tyr Ile Phe Thr Leu Val Pro Ala Gly Cys Leu His Phe Gly Leu Pro Ile His Gly Ala Phe Ser Ser <210> 27 <211> 2442 <212> DNA
<213> homo sapiens <400> 27 atgtatgtgcgagtatcttttgatacaaaacctgatctcctcttacacctgatgaccaag 60 gaatggcagttggagcttcccaagcttctcatctctgtccatgggggcctgcagaacttt 120 gaactccagccaaaactcaagcaagtctttgggaaagggctcatcaaagcagcaatgaca 180 actggagcgtggatattcactggaggggttaacacaggtgttattcgtcatgttggcgat 240 gccttgaaggatcatgcctctaagtctcgaggaaagatatgcaccataggtattgccccc 300 tggggaattgtggaaaaccaggaggacctcattggaagagatgttgtccggccataccag 360 accatgtccaatcccatgagcaagctcactgttctcaacagcatgcattcccacttcatt 420 ctggctgacaacgggaccactggaaaatatggagcagaggtgaaacttcgaagacaactg 480 gaaaagcatatttcactccagaagataaacacaagatgcctgccgtttttctctcttgac 540 tcccgcttgttttattcattttggggtagttgccagttagactcagttggaatcggtcaa 600 ggtgttcctgtggtggcactcatagtggaaggaggacccaatgtgatctcgattgttttg 660 gagtaccttcgagacacccctcccgtgccagtggttgtctgtgatgggagtggacgggca 720 tcggacatcctggcctttgggcataaatactcagaagaaggcggactgataaatgaatct 780 ttgagggaccagctgttggtgactatacagaagactttcacatacactcgaacccaagct 840 cagcatctgttcatcatcctcatggagtgcatgaagaagaaggaattgattacggtattt 900 cggatgggatcagaaggacaccaggacattgatttggctatcctgacagctttactcaaa 960 ggagccaatgcctcggccccagaccaactgagcttagctttagcctggaacagagtcgac 1020 atcgctcgcagccagatctttatttacgggcaacagtggccggtgggatctctggagcaa 1080 gccatgttggatgccttagttctggacagagtggattttgtgaaattactcatagagaat 1140 ggagtaagcatgcaccgttttctcaccatctccagactagaggaattgtacaatacgaga 1200 catgggccctcaaatacattgtaccacttggtcagggatgtcaaaaaggggaacctgccc 1260 ccagactacagaatcagcctgattgacatcggcctggtgatcgagtacctgatgggcggg 1320 gcttatcgctgcaactacacgcgcaagcgcttccggaccctctaccacaacctcttcggc 1380 cccaagagggatgatattcccttgaggcgaggaagaaagacaaccaagaaacgtgaagaa 1440 gaggtggacattgacttggatgatcctgagatcaaccacttccccttccctttccatgag 1500 ctcatggtgtgggctgttctcatgaagcggcagaagatggccctgttcttctggcagcac 1560 ggtgaggaggccatggccaaggccctggtggcctgcaagctctgcaaagccatggctcat 1620 gaggcctctgagaacgacatggttgacgacatttcccaggagctgaatcacaattccaga 1680 gactttggccagctggctgtggagctcctggaccagtcctacaagcaggacgaacagctg 1740 gccatgaaactgctgacgtatgagctgaagaactggagcaacgccacgtgcctgcagctt 1800 gccgtggctgccaaacaccgcgacttcatcgcgcacacgtgcagccagatgctgctcacc 1860 gacatgtggatgggccggctccgcatgcgcaagaactcaggcctcaaggtaattctggga 1920 attctacttcctccttcaattctcagcttggagttcaagaacaaagacgacatgccctat 1980 atgtctcaggcccaggaaatccacctccaagagaaggaggcagaagaaccagagaagccc 2040 acaaaggaaaaagaggaagaggacatggagctcacagcaatgttgggacgaaacaacggg 2100 gagtcctccaggaagaaggatgaagaggaagttcagagcaagcaccggttaatccccctc 2160 ggcagaaaaatctatgaattctacaatgcacccatcgtgaagttctggttctacacactg 2220 gcgtatatcggatacctgatgctcttcaactatatcgtgttagtgaagatggaacgctgg 2280 ccgtccacccaggaatggatcgtaatctcctatattttcaccctgggaatagaaaagatg 2340 agagaggtaacggcttttataaaagaaaacgtaagagaaagacagtggttaagttctatc 2400 tgtggatggaggggacaggaagatgcctgggatgcaaattas 2442 <210> 28 <211> 813 <212> PRT
<213> homo Sapiens <400> 28 Met Tyr Val Arg Val Ser Phe Asp Thr Lys Pro Asp Leu Leu Leu His Leu Met Thr Lys Glu Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser Val His Gly Gly Leu Gln Asn Phe Glu Leu Gln Pro Lys Leu Lys Gln Val Phe Gly Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp Ile Phe Thr Gly Gly Val Asn Thr Gly Val Ile Arg His Val Gly Asp Ala Leu Lys Asp His Ala Ser Lys Ser Arg Gly Lys Ile Cys Thr Ile Gly Ile Ala Pro Trp Gly Ile Val Glu Asn Gln Glu Asp Leu Ile Gly Arg Asp Val Val Arg Pro Tyr Gln Thr Met Ser Asn Pro Met Ser Lys Leu Thr Val Leu Asn Ser Met His Ser His Phe Ile Leu Ala Asp Asn Gly Thr Thr Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Gln Leu Glu Lys His Ile Ser Leu Gln Lys Ile Asn Thr Arg Cys Leu Pro Phe Phe Ser Leu Asp Ser Arg Leu Phe Tyr Ser Phe Trp Gly Ser Cys Gln Leu Asp Ser Val Gly Ile Gly Gln Gly Val Pro Val Val Ala Leu Ile Val Glu Gly Gly Pro Asn Val Ile Ser Ile Val Leu Glu Tyr Leu Arg Asp Thr Pro Pro Val Pro Val Val Val Cys Asp Gly Ser Gly Arg Ala Ser Asp Ile Leu Ala Phe Gly His Lys Tyr Ser Glu Glu Gly Gly Leu Ile Asn Glu Ser Leu Arg Asp Gln Leu Leu Val Thr Ile Gln Lys Thr Phe Thr Tyr Thr Arg Thr Gln Ala Gln His Leu Phe Ile Ile Leu Met Glu Cys Met Lys Lys Lys Glu Leu Ile Thr Val Phe Arg Met Gly Ser Glu Gly His Gln Asp Ile Asp Leu Ala Ile Leu Thr Ala Leu Leu Lys Gly Ala Asn Ala Ser Ala Pro Asp Gln Leu Ser Leu Ala Leu Ala Trp Asn Arg Val Asp Ile Ala Arg Ser Gln Ile Phe Ile Tyr Gly Gln Gln Trp Pro Val Gly Ser Leu Glu Gln Ala Met Leu Asp Ala Leu Val Leu Asp Arg Val Asp Phe Val Lys Leu Leu Ile Glu Asn Gly Val Ser Met His Arg Phe Leu Thr Ile Ser Arg Leu Glu Glu Leu Tyr Asn Thr Arg His Gly Pro Ser Asn Thr Leu Tyr His Leu Val Arg Asp Val Lys Lys Gly Asn Leu Pro Pro Asp Tyr Arg Ile Ser Leu Ile Asp Ile Gly Leu Val Ile Glu Tyr Leu Met Gly Gly Ala Tyr Arg Cys Asn Tyr Thr Arg Lys Arg Phe Arg Thr Leu Tyr His Asn Leu Phe Gly Pro Lys Arg Asp Asp Ile Pro Leu Arg Arg Gly Arg Lys Thr Thr Lys Lys Arg Glu Glu Glu Val Asp Ile Asp Leu Asp Asp Pro Glu Ile Asn His Phe Pro Phe Pro Phe His Glu Leu Met Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala Leu Phe Phe Trp Gln His Gly Glu Glu Ala Met Ala Lys Ala Leu Val Ala Cys Lys Leu Cys Lys Ala Met Ala His Glu Ala Ser Glu Asn Asp Met Val Asp Asp Ile Ser Gln Glu Leu Asn His Asn Ser Arg Asp Phe Gly Gln Leu Ala Val Glu Leu Leu Asp Gln Ser Tyr Lys Gln Asp Glu Gln Leu Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ala Thr Cys Leu Gln Leu Ala Val Ala Ala Lys His Arg Asp Phe Ile Ala His Thr Cys Ser Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg Leu Arg Met Arg Lys Asn Ser Gly Leu Lys Val Ile Leu Gly Ile Leu Leu Pro Pro Ser Ile Leu Ser Leu Glu Phe Lys Asn Lys Asp Asp Met Pro Tyr Met Ser Gln Ala Gln Glu Ile His Leu Gln Glu Lys Glu Ala Glu Glu Pro Glu Lys Pro Thr Lys Glu Lys Glu Glu Glu Asp Met Glu Leu Thr Ala Met Leu Gly Arg Asn Asn Gly Glu Ser Ser Arg Lys Lys Asp Glu Glu Glu Val Gln Ser Lys His Arg Leu Ile Pro Leu Gly Arg Lys Ile Tyr Glu Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Leu Ala Tyr Ile Gly Tyr Leu Met Leu Phe Asn Tyr Ile Val Leu Val Lys Met Glu Arg Trp Pro Ser Thr Gln Glu Trp Ile Val Ile Ser Tyr Ile Phe Thr Leu Gly Ile Glu Lys Met Arg Glu Val Thr Ala Phe Ile Lys Glu Asn Val Arg Glu Arg Gln Trp Leu Ser Ser Ile Cys Gly Trp Arg Gly Gln Glu Asp Ala Trp Asp Ala Asn <210> 29 <211> 2817 <212> DNA
<213> homo sapiens <400> 29 atgtatgtgcgagtatcttttgatacaaaacctgatctcctcttacacctgatgaccaag 60 gaatggcagttggagcttcccaagcttctcatctctgtccatgggggcctgcagaacttt 120 gaactccagccaaaactcaagcaagtctttgggaaagggctcatcaaagcagcaatgaca 180 actggagcgtggatattcactggaggggttaacacaggtgttattcgtcatgttggcgat 240 gccttgaaggatcatgcctctaagtctcgaggaaagatatgcaccataggtattgccccc 300 tggggaattgtggaaaaccaggaggacctcattggaagagatgttgtccggccataccag 360 accatgtccaatcccatgagcaagctcactgttctcaacagcatgcattcccacttcatt 420 ctggctgacaacgggaccactggaaaatatggagcagaggtgaaacttcgaagacaactg 480 gaaaagcatatttcactccagaagataaacacaagatgcctgccgtttttctctcttgac 540 tcccgcttgttttattcattttggggtagttgccagttagactcagttggaatcggtcaa 600 ggtgttcctgtggtggcactcatagtggaaggaggacccaatgtgatctcgattgttttg 660 gagtaccttcgagacacccctcccgtgccagtggttgtctgtgatgggagtggacgggca 720 tcggacatcctggcctttgggcataaatactcagaagaaggcggactgataaatgaatct 780 ttgagggaccagctgttggtgactatacagaagactttcacatacactcgaacccaagct 840 Cagcatctgttcatcatcctcatggagtgcatgaagaagaaggaattgattacggtattt 900 cggatgggatcagaaggacaccaggacattgatttggctatcctgacagctttactcaaa 960 ggagccaatgcctcggccccagaccaactgagcttagctttagcctggaacagagtcgac 1020 atcgctcgcagccagatctttatttacgggcaacagtggccggtgggatctctggagcaa 1080 gccatgttggatgccttagttctggacagagtggattttgtgaaattactcatagagaat 1140 ggagtaagcatgcaccgttttctcaccatctccagactagaggaattgtacaatacgaga 1200 catgggccctcaaatacattgtaccacttggtcagggatgtcaaaaaggggaacctgccc 1260 ccagactacagaatcagcctgattgacatcggcctggtgatcgagtacctgatgggcggg 1320 gcttatcgctgcaactacacgcgcaagcgcttccggaccctctaccacaacctcttcggc 1380 cccaagagggatgatattcccttgaggcgaggaagaaagacaaccaagaaacgtgaagaa 1440 gaggtggacattgacttggatgatcctgagatcaaccacttccccttccctttccatgag 1500 ctcatggtgtgggctgttctcatgaagcggcagaagatggccctgttcttctggcagcac 1560 ggtgaggaggccatggccaaggccctggtggcctgcaagctctgcaaagccatggctcat 1620 gaggcctctgagaacgacatggttgacgacatttcccaggagctgaatcacaattccaga 1680 gactttggccagctggctgtggagctcctggaccagtcctacaagcaggacgaacagctg 1740 gccatgaaactgctgacgtatgagctgaagaactggagcaacgccacgtgcctgcagctt 1800 gccgtggctgccaaacaccgcgacttcatcgcgcacacgtgcagccagatgctgctcacc 1860 gacatgtggatgggccggctccgcatgcgcaagaactcaggcctcaaggtaattctggga 1920 attctacttcctccttcaattctcagcttggagttcaagaacaaagacgacatgccctat 1980 atgtctcaggcccaggaaatccacctccaagagaaggaggcagaagaaccagagaagccc 2040 acaaaggaaaaagaggaagaggacatggagctcacagcaatgttgggacgaaacaacggg 2100 gagtcctccaggaagaaggatgaagaggaagttcagagcaagcaccggttaatccccctc 2160 ggcagaaaaatctatgaattctacaatgcacccatcgtgaagttctggttctacacactg 2220 gcgtatatcggatacctgatgctcttcaactatatcgtgttagtgaagatggaacgctgg 2280 ccgtccacccaggaatggatcgtaatctcctatattttcaccctgggaatagaaaagatg 2340 agagagattctgatgtcagagccagggaagttgctacagaaagtgaaggtatggctgcag 2400 gagtactggaatgtcacggacctcatcgccatccttctgttttctgtcggaatgatcctt 2460 cgtctccaagaccagcccttcaggagtgacgggagggtcatctactgcgtgaacatcatt 2520 tactggtatatccgtctcctagacatcttcggcgtgaacaagtatttgggcccgtatgta 2580 atgatgattggaaaaatgatgatagacatgatgtactttgtcatcattatgctggtggtt 2640 ctgatgagctttggggtcgccaggcaagccatcctttttcccaatgaggagccatcatgg 2700 aaactggccaagaacatcttctacatgccctattggatgatttatggggaagtgtttgcg 2760 gaccagatagaccgtaagcaagtttatgattctcatacaccaaagtcaggtatttaa 2817 <210> 30 <211> 938 <212> PRT
<213> homo sapiens <400> 30 Met Tyr Val Arg Val Ser Phe Asp Thr Lys Pro Asp Leu Leu Leu His Leu Met Thr Lys Glu Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser Val His Gly Gly Leu Gln Asn Phe Glu Leu Gln Pro Lys Leu Lys Gln Val Phe Gly Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp Ile Phe Thr Gly Gly Val Asn Thr Gly Val Ile Arg His Val Gly Asp Ala Leu Lys Asp His Ala Ser Lys Ser Arg Gly Lys Ile Cys Thr Ile Gly Ile Ala Pro Trp Gly Ile Val Glu Asn Gln Glu Asp Leu Ile Gly Arg Asp Val Val Arg Pro Tyr Gln Thr Met Ser Asn Pro Met Ser Lys Leu Thr Val Leu Asn Ser Met His Ser His Phe Ile Leu Ala Asp Asn Gly Thr Thr Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Gln Leu Glu Lys His Ile Ser Leu Gln Lys Ile Asn Thr Arg Cys Leu Pro Phe Phe Ser Leu Asp Ser Arg Leu Phe Tyr Ser Phe Trp Gly Ser Cys Gln Leu Asp Ser Val Gly Ile Gly Gln Gly Val Pro Val Val Ala Leu Ile Val Glu Gly Gly Pro Asn Val Ile Ser Ile Val Leu Glu Tyr Leu Arg Asp Thr Pro Pro Val Pro Val Val Val Cys Asp Gly Ser Gly Arg Ala Ser Asp Ile Leu Ala Phe Gly His Lys Tyr Ser Glu Glu Gly Gly Leu Ile Asn Glu Ser Leu Arg Asp Gln Leu Leu Val Thr Ile Gln Lys Thr Phe Thr Tyr Thr Arg Thr Gln Ala Gln His Leu Phe Ile Ile Leu Met Glu Cys Met Lys Lys Lys Glu Leu Ile Thr Val Phe Arg Met Gly Ser Glu Gly His Gln Asp Ile Asp Leu Ala Ile Leu Thr Ala Leu Leu Lys Gly Ala Asn Ala Ser Ala Pro Asp Gln Leu Ser Leu Ala Leu Ala Trp Asn Arg Val Asp Ile Ala Arg Ser Gln Ile Phe Ile Tyr Gly Gln Gln Trp Pro Val Gly Ser Leu Glu Gln Ala Met Leu Asp Ala Leu Val Leu Asp Arg Val Asp Phe Val Lys Leu Leu Ile Glu Asn Gly Val Ser Met His Arg Phe Leu Thr Ile Ser Arg Leu Glu Glu Leu Tyr Asn Thr Arg His Gly Pro Ser Asn Thr Leu Tyr His Leu Val Arg Asp Val Lys Lys Gly Asn Leu Pro Pro Asp Tyr Arg Ile Ser Leu Ile Asp Ile Gly Leu Val Ile Glu Tyr Leu Met Gly Gly Ala Tyr Arg Cys Asn Tyr Thr Arg Lys Arg Phe Arg Thr Leu Tyr His Asn Leu Phe Gly Pro Lys Arg Asp Asp Ile Pro Leu Arg Arg Gly Arg Lys Thr Thr Lys Lys Arg Glu Glu Glu Val Asp Ile Asp Leu Asp Asp Pro Glu Ile Asn His Phe Pro Phe Pro Phe His Glu Leu Met Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala Leu Phe Phe Trp Gln His Gly Glu Glu Ala Met Ala Lys Ala Leu Val Ala Cys Lys Leu Cys Lys Ala Met Ala His Glu Ala Ser Glu Asn Asp Met Val Asp Asp Ile Ser Gln Glu Leu Asn His Asn Ser Arg Asp Phe Gly Gln Leu Ala Val Glu Leu Leu Asp Gln Ser Tyr Lys Gln Asp Glu Gln Leu Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ala Thr Cys Leu Gln Leu Ala Val Ala Ala Lys His Arg Asp Phe Ile Ala His Thr Cys Ser Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg Leu Arg Met Arg Lys Asn Ser Gly Leu Lys Val Ile Leu Gly Ile Leu Leu Pro Pro Ser Ile Leu Ser Leu Glu Phe Lys Asn Lys Asp Asp Met Pro Tyr Met Ser Gln Ala Gln Glu Ile His Leu Gln Glu Lys Glu Ala Glu Glu Pro Glu Lys Pro Thr Lys Glu Lys Glu Glu Glu Asp Met Glu Leu Thr Ala Met Leu Gly Arg Asn Asn Gly Glu Ser Ser Arg Lys Lys Asp Glu Glu Glu Val Gln Ser Lys His Arg Leu Ile Pro Leu Gly Arg Lys Ile Tyr Glu Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Leu Ala Tyr Ile Gly Tyr Leu Met Leu Phe Asn Tyr Ile Val Leu Val Lys Met Glu Arg Trp Pro Ser Thr Gln Glu Trp Ile Val Ile Ser Tyr Ile Phe Thr Leu Gly Ile Glu Lys Met Arg Glu Ile Leu Met Ser Glu Pro Gly Lys Leu Leu Gln Lys Val Lys Val Trp Leu Gln Glu Tyr Trp Asn Val Thr Asp Leu Ile Ala Ile Leu Leu Phe Ser Val Gly Met Ile Leu Arg Leu Gln Asp Gln Pro Phe Arg Ser Asp Gly Arg Val Ile Tyr Cys Val Asn Ile Ile Tyr Trp Tyr Ile Arg Leu Leu Asp Ile Phe Gly Val Asn Lys Tyr Leu Gly Pro Tyr Val Met Met Ile Gly Lys Met Met Ile Asp Met Met Tyr Phe Val Ile Ile Met Leu Val Val Leu Met Ser Phe Gly Val Ala Arg Gln Ala Ile Leu Phe Pro Asn Glu Glu Pro Ser Trp Lys Leu Ala Lys Asn Ile Phe Tyr Met Pro Tyr Trp Met Ile Tyr Gly Glu Val Phe Ala Asp Gln Ile Asp Arg Lys Gln Val Tyr Asp Ser His Thr Pro Lys Ser Gly Ile , <210> 31 <211> 3375 <212> DNA
<213> homo sapiens <400> 31 atgtatgtgcgagtatcttttgatacaaaacctgatctcctcttacacctgatgaccaag60 gaatggcagttggagcttcccaagcttctcatctctgtccatgggggcctgcagaacttt120 gaactccagccaaaactcaagcaagtctttgggaaagggctcatcaaagcagcaatgaca180 actggagcgtggatattcactggaggggttaacacaggtgttattcgtcatgttggcgat240 gccttgaaggatcatgcctctaagtctcgaggaaagatatgcaccataggtattgccccc300 tggggaattgtggaaaaccaggaggacctcattggaagagatgttgtccggccataccag360 accatgtccaatcccatgagcaagctcactgttctcaacagcatgcattcccacttcatt420 ctggctgacaacgggaccactggaaaatatggagcagaggtgaaacttcgaagacaactg480 gaaaagcatatttcactccagaagataaacacaagatgcctgccgtttttctctcttgac540 tcccgcttgttttattcattttggggtagttgccagttagactcagttggaatcggtcaa600 ggtgttcctgtggtggcactcatagtggaaggaggacccaatgtgatctcgattgttttg660 gagtaccttcgagacacccctcccgtgccagtggttgtctgtgatgggagtggacgggca720 tcggacatcctggcctttgggcataaatactcagaagaaggcggactgataaatgaatct780 ttgagggaccagctgttggtgactatacagaagactttcacatacactcgaacccaagct840 cagcatctgttcatcatcctcatggagtgcatgaagaagaaggaattgattacggtattt900 cggatgggatcagaaggacaccaggacattgatttggctatcctgacagctttactcaaa960 ggagccaatgcctcggccccagaccaactgagcttagctttagcctggaacagagtcgac1020 atcgctcgcagccagatctttatttacgggcaacagtggccggtgggatctctggagcaa1080 gccatgttggatgccttagttctggacagagtggattttgtgaaattactcatagagaat1140 ggagtaagcatgcaccgttttctcaccatctccagactagaggaattgtacaatacgaga1200 catgggccctcaaatacattgtaccacttggtcagggatgtcaaaaaggggaacctgccc1260 ccagactacagaatcagcctgattgacatcggcctggtgatcgagtacctgatgggcggg1320 gcttatcgctgcaactacacgcgcaagcgcttccggaccctctaccacaacctcttcggc1380 cccaagagggatgatattcccttgaggcgaggaagaaagacaaccaagaaacgtgaagaa1440 gaggtggacattgacttggatgatcctgagatcaaccacttccccttccctttccatgag1500 ctcatggtgtgggctgttctcatgaagcggcagaagatggccctgttcttctggcagcac1560 ggtgaggaggccatggccaaggccctggtggcctgcaagctctgcaaagccatggctcat1620 gaggcctctgagaacgacatggttgacgacatttcccaggagctgaatcacaattccaga1680 gactttggccagctggctgtggagctcctggaccagtcctacaagcaggacgaacagctg1740 gccatgaaactgctgacgtatgagctgaagaactggagcaacgccacgtgcctgcagctt1800 gccgtggctgccaaacaccgcgacttcatcgcgcacacgtgcagccagatgctgctcacc1860 gacatgtggatgggccggctccgcatgcgcaagaactcaggcctcaaggtaattctggga1920 attctacttcctccttcaattctcagcttggagttcaagaacaaagacgacatgccctat1980 atgtctcaggcccaggaaatccacctccaagagaaggaggcagaagaaccagagaagccc2040 acaaaggaaaaagaggaagaggacatggagctcacagcaatgttgggacgaaacaacggg2100 gagtcctccaggaagaaggatgaagaggaagttcagagcaagcaccggttaatccccctc2160 ggcagaaaaatctatgaattctacaatgcacccatcgtgaagttctggttctacacactg2220 gcgtatatcggatacctgatgctcttcaactatatcgtgttagtgaagatggaacgctgg2280 ccgtccacccaggaatggatcgtaatctcctatattttcaccctgggaatagaaaagatg2340 agagagattctgatgtcagagccagggaagttgctacagaaagtgaaggtatggctgcag2400 gagtactggaatgtcacggacctcatcgccatccttctgttttctgtcggaatgatcctt2460 cgtctccaagaccagcccttcaggagtgacgggagggtcatctactgcgtgaacatcatt2520 tactggtatatccgtctcctagacatcttcggcgtgaacaagtatttgggcccgtatgta2580 atgatgattggaaaaatgatgatagacatgatgtactttgtcatcattatgctggtggtt2640 ctgatgagctttggggtcgccaggcaagccatcctttttcccaatgaggagccatcatgg2700 aaactggccaagaacatcttctacatgccctattggatgatttatggggaagtgtttgcg2760 gaccagatagaccctccctgtggacagaatgagacccgagaggatggtaaaataatccag2820 ctgcctccctgcaagacaggagcttggatcgtgccggccatcatggcctgctacctctta2880 gtggcaaacatcttgctggtcaacctcctcattgctgtctttaacaatacattttttgaa2940 gtaaaatcgatatccaaccaagtctggaagtttcagaggtatcagctcatcatgactttc3000 catgaaaggccagttctgcccccaccactgatcatcttcagccacatgaccatgatattc3060 cagcacctgtgctgccgatggaggaaacacgagagcgacccggatgaaagggactacggc3120 ctgaaactcttcataaccgatgatgagctcaagaaagtacatgactttgaagagcaatgc3180 atagaagaatacttcagagaaaaggatgatcggttcaactcatctaatgatgagaggata3240 cgggtgacttcagaaaggtgtgttctgtggacacctgcctcctgcagatgtgttgtgcca3300 aggcatgctttatccatcgaatttattcacacggtcacaaaacagagatcttttgtgttt3360 gtttttattgtctga 3375 <210> 32 <211> 1124 <212> PRT
<213> homo Sapiens <400> 32 Met Tyr Val Arg Val Ser Phe Asp Thr Lys Pro Asp Leu Leu Leu His Leu Met Thr Lys Glu Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser Val His Gly Gly Leu Gln Asn Phe Glu Leu Gln Pro Lys Leu Lys Gln Val Phe Gly Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp Ile Phe Thr Gly Gly Val Asn Thr Gly Val Ile Arg His Val Gly Asp Ala Leu Lys Asp His Ala Ser Lys Ser Arg Gly Lys Ile Cys Thr Ile Gly Ile Ala Pro Trp Gly Ile Val Glu Asn Gln Glu Asp Leu Ile Gly Arg Asp Val Val Arg Pro Tyr Gln Thr Met Ser Asn Pro Met Ser Lys Leu Thr Val Leu Asn Ser Met His Ser His Phe Ile Leu Ala Asp Asn Gly Thr Thr Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Gln Leu Glu Lys His Ile Ser Leu Gln Lys Ile Asn Thr Arg Cys Leu Pro Phe Phe Ser Leu Asp Ser Arg Leu Phe Tyr Ser Phe Trp Gly Ser Cys Gln Leu Asp Ser Val Gly Ile Gly Gln Gly Val Pro Val Val Ala Leu Ile Val Glu Gly Gly Pro Asn Val Ile Ser Ile Val Leu Glu Tyr Leu Arg Asp Thr Pro Pro Val Pro Val Val Val Cys Asp Gly Ser Gly Arg Ala Ser Asp Ile Leu Ala Phe Gly His Lys Tyr Ser Glu Glu Gly Gly Leu Ile Asn Glu Ser Leu Arg Asp Gln Leu Leu Val Thr Ile Gln Lys Thr Phe Thr Tyr Thr Arg Thr Gln Ala Gln His Leu Phe Ile Ile Leu Met Glu Cys Met Lys Lys Lys Glu Leu Ile Thr Val Phe Arg Met Gly Ser Glu Gly His Gln Asp Ile Asp Leu Ala Ile Leu Thr Ala Leu Leu Lys Gly Ala Asn Ala Ser Ala Pro Asp Gln Leu Ser Leu Ala Leu Ala Trp Asn Arg Val Asp Ile Ala Arg Ser Gln Ile Phe Ile Tyr Gly Gln Gln Trp Pro Val Gly Ser Leu Glu Gln Ala Met Leu Asp Ala Leu Val Leu Asp Arg Val Asp Phe Val Lys Leu Leu Ile Glu Asn Gly Val Ser Met His Arg Phe Leu Thr Ile Ser Arg Leu Glu Glu Leu Tyr Asn Thr Arg His Gly Pro Ser Asn Thr Leu Tyr His Leu Val Arg Asp Val Lys Lys Gly Asn Leu Pro Pro Asp Tyr Arg Ile Ser Leu Ile Asp Ile Gly Leu Val Ile Glu Tyr Leu Met Gly Gly Ala Tyr Arg Cys Asn Tyr Thr Arg Lys Arg Phe Arg Thr Leu Tyr His Asn Leu Phe Gly Pro Lys Arg Asp Asp Ile Pro Leu Arg Arg Gly Arg Lys Thr Thr Lys Lys Arg Glu Glu Glu Val Asp Ile Asp Leu Asp Asp Pro Glu Ile Asn His Phe Pro Phe Pro Phe His Glu Leu Met Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala Leu Phe Phe Trp Gln His Gly Glu Glu Ala Met Ala Lys Ala Leu Val Ala Cys Lys Leu Cys Lys Ala Met Ala His Glu Ala Ser Glu Asn Asp Met Val Asp Asp Ile Ser Gln Glu Leu Asn His Asn Ser Arg Asp Phe Gly Gln Leu Ala Val Glu Leu Leu Asp Gln Ser Tyr Lys Gln Asp Glu Gln Leu Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ala Thr Cys Leu Gln Leu Ala Val Ala Ala Lys His Arg Asp Phe Ile Ala His Thr Cys Ser Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg Leu Arg Met Arg Lys Asn Ser Gly Leu Lys Val Ile Leu Gly Ile Leu Leu Pro Pro Ser Ile Leu Ser Leu Glu Phe Lys Asn Lys Asp Asp Met Pro Tyr Met Ser Gln Ala Gln Glu Ile His Leu Gln Glu Lys Glu Ala Glu Glu Pro Glu Lys Pro Thr Lys Glu Lys Glu Glu Glu Asp Met Glu Leu Thr Ala Met Leu Gly Arg Asn Asn Gly Glu Ser Ser Arg Lys Lys Asp Glu Glu Glu Val Gln Ser Lys His Arg Leu Ile Pro Leu Gly Arg Lys Ile Tyr Glu Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Leu Ala Tyr Ile Gly Tyr Leu Met Leu Phe Asn Tyr Ile Val Leu Val Lys Met Glu Arg Trp Pro Ser Thr Gln Glu Trp Ile Val Ile Ser Tyr Ile Phe Thr Leu Gly Ile Glu Lys Met Arg Glu Ile Leu Met Ser Glu Pro Gly Lys Leu Leu Gln Lys Val Lys Val Trp Leu Gln Glu Tyr Trp Asn Val Thr Asp Leu Ile Ala Ile Leu Leu Phe Ser Val Gly Met Ile Leu Arg Leu Gln Asp Gln Pro Phe Arg Ser Asp Gly Arg Val Ile Tyr Cys Val Asn Ile Ile Tyr Trp Tyr Ile Arg Leu Leu Asp Ile Phe Gly Val Asn Lys Tyr Leu Gly Pro Tyr Val Met Met Ile Gly Lys Met Met Ile Asp Met Met Tyr Phe Val Ile Ile Met Leu Val Val Leu Met Ser Phe Gly Val Ala Arg Gln Ala Ile Leu Phe Pro Asn Glu Glu Pro Ser Trp Lys Leu Ala Lys Asn Ile Phe Tyr Met Pro Tyr Trp Met Ile Tyr Gly Glu Val Phe Ala Asp Gln Ile Asp Pro Pro Cys Gly Gln Asn Glu Thr Arg Glu Asp Gly Lys Ile Ile Gln Leu Pro Pro Cys Lys Thr Gly Ala Trp Ile Val Pro Ala Ile Met Ala Cys Tyr Leu Leu Val Ala Asn Ile Leu Leu Val Asn Leu Leu Ile Ala Val Phe Asn Asn Thr Phe Phe Glu Val Lys Ser Ile Ser Asn Gln Val Trp Lys Phe Gln Arg Tyr Gln Leu Ile Met Thr Phe His Glu Arg Pro Val Leu Pro Pro Pro Leu Ile Ile Phe Ser His Met Thr Met Ile Phe Gln His Leu Cys Cys Arg Trp Arg Lys His Glu Ser Asp Pro Asp Glu Arg Asp Tyr Gly Leu Lys Leu Phe Ile Thr Asp Asp Glu Leu Lys Lys Val His Asp Phe Glu Glu Gln Cys Ile Glu Glu Tyr Phe Arg Glu Lys Asp Asp Arg Phe Asn Ser Ser Asn Asp Glu Arg Ile Arg Val Thr Ser Glu Arg Cys Val Leu Trp Thr Pro Ala Ser Cys Arg Cys Val Val Pro Arg His Ala Leu Ser Ile Glu Phe Ile His Thr Val Thr Lys Gln Arg Ser Phe Val Phe Val Phe Ile Val <210> 33 <211> 3564 <212> DNA

<213> homo sapiens <400>

atgtatgtgcgagtatcttttgatacaaaacctgatctcctcttacacctgatgaccaag 60 gaatggcagttggagcttcccaagcttctcatctctgtccatgggggcctgcagaacttt 120 gaactccagccaaaactcaagcaagtctttgggaaagggctcatcaaagcagcaatgaca 180 actggagcgtggatattcactggaggggttaacacaggtgttattcgtcatgttggcgat 240 gccttgaaggatcatgcctctaagtctcgaggaaagatatgcaccataggtattgccccc 300 tggggaattgtggaaaaccaggaggacctcattggaagagatgttgtccggccataccag 360 accatgtccaatcccatgagcaagctcactgttctcaacagcatgcattcccacttcatt 420 ctggctgacaacgggaccactggaaaatatggagcagaggtgaaacttcgaagacaactg 480 gaaaagcatatttcactccagaagataaacacaagatgcctgccgtttttctctcttgac 540 tcccgcttgttttattcattttggggtagttgccagttagactcagttggaatcggtcaa 600 ggtgttcctgtggtggcactcatagtggaaggaggacccaatgtgatctcgattgttttg 660 gagtaccttcgagacacccctcccgtgccagtggttgtctgtgatgggagtggacgggca 720 tcggacatcctggcctttgggcataaatactcagaagaaggcggactgataaatgaatct 780 ttgagggaccagctgttggtgactatacagaagactttcacatacactcgaacccaagct 840 cagcatctgttcatcatcctcatggagtgcatgaagaagaaggaattgattacggtattt 900 cggatgggatcagaaggacaccaggacattgatttggctatcctgacagctttactcaaa 960 ggagccaatgcctcggccccagaccaactgagcttagctttagcctggaacagagtcgac 1020 atcgctcgcagccagatctttatttacgggcaacagtggccggtgggatctctggagcaa 1080 gccatgttggatgccttagttctggacagagtggattttgtgaaattactcatagagaat 1140 ggagtaagcatgcaccgttttctcaccatctccagactagaggaattgtacaatacgaga 1200 catgggccctcaaatacattgtaccacttggtcagggatgtcaaaaaggggaacctgccc 1260 ccagactacagaatcagcctgattgacatcggcctggtgatcgagtacctgatgggcggg 1320 gcttatcgctgcaactacacgcgcaagcgcttccggaccctctaccacaacctcttcggc 1380 cccaagagggatgatattcccttgaggcgaggaagaaagacaaccaagaaacgtgaagaa 1440 gaggtggacattgacttggatgatcctgagatcaaccacttccccttccctttccatgag 1500 ctcatggtgtgggctgttctcatgaagcggcagaagatggccctgttcttctggcagcac 1560 ggtgaggaggccatggccaaggccctggtggcctgcaagctctgcaaagccatggctcat 1620 gaggcctctgagaacgacatggttgacgacatttcccaggagctgaatcacaattccaga 1680 gactttggccagctggctgtggagctcctggaccagtcctacaagcaggacgaacagctg 1740 gccatgaaactgctgacgtatgagctgaagaactggagcaacgccacgtgcctgcagctt 1800 gccgtggctgccaaacaccgcgacttcatcgcgcacacgtgcagccagatgctgctcacc 1860 gacatgtggatgggccggctccgcatgcgcaagaactcaggcctcaaggtaattctggga 1920 attctacttcctccttcaattctcagcttggagttcaagaacaaagacgacatgccctat 1980 atgtctcaggcccaggaaatccacctccaagagaaggaggcagaagaaccagagaagccc 2040 acaaaggaaaaagaggaagaggacatggagctcacagcaatgttgggacgaaacaacggg 2100 gagtcctccaggaagaaggatgaagaggaagttcagagcaagcaccggttaatccccctc 2160 ggcagaaaaatctatgaattctacaatgcacccatcgtgaagttctggttctacacactg 2220 gcgtatatcggatacctgatgctcttcaactatatcgtgttagtgaagatggaacgctgg 2280 ccgtccacccaggaatggatcgtaatctcctatattttcaccctgggaatagaaaagatg 2340 agagagattctgatgtcagagccagggaagttgctacagaaagtgaaggtatggctgcag 2400 gagtactggaatgtcacggacctcatcgccatccttctgttttctgtcggaatgatcctt 2460 cgtctccaagaccagcccttcaggagtgacgggagggtcatctactgcgtgaacatcatt 2520 tactggtatatccgtctcctagacatcttcggcgtgaacaagtatttgggcccgtatgta 2580 atgatgattggaaaaatgatgatagacatgatgtactttgtcatcattatgctggtggtt 2640 ctgatgagctttggggtcgccaggcaagccatcctttttcccaatgaggagccatcatgg 2700 aaactggccaagaacatcttctacatgccctattggatgatttatggggaagtgtttgcg 2760 gaccagatagaccctccctgtggacagaatgagacccgagaggatggtaaaataatccag 2820 ctgcctccctgcaagacaggagcttggatcgtgccggccatcatggcctgctacctctta 2880 gtggcaaacatcttgctggtcaacctcctcattgctgtctttaacaatacattttttgaa 2940 gtaaaatcgatatccaaccaagtctggaagtttcagaggtatcagctcatcatgactttc 3000 catgaaaggccagttctgcccccaccactgatcatcttcagccacatgaccatgatattc 3060 cagcacctgtgctgccgatggaggaaacacgagagcgacccggatgaaagggactacggc 3120 ctgaaactcttcataaccgatgatgagctcaagaaagtacatgactttgaagagcaatgc 3180 atagaagaatacttcagagaaaaggatgatcggttcaactcatctaatgatgagaggata 3240 cgggtgacttcagaaagggtggagaacatgtctatgcggctggaggaagtcaacgagaga 3300 gagcactccatgaaggcttcactccagaccgtggacatccggctggcgcagctggaagac 3360 cttatcgggcgcatggccacggccctggagCJCCtgaCaggtctggagcgggccgagtcc 3420 aacaaaatccgctcgaggacctcgtcagactgcacggacgccgcctacattgtccgtcag 3480 agcagcttcaacagccaggaagggaacaccttcaagctccaagagagtatagaccctgca 3540 gagcatcctctttattcagtataa 3564 <210> 34 <211> 1187 <212> PRT
<213> homo Sapiens <400> 34 Met Tyr Val Arg Val Ser Phe Asp Thr Lys Pro Asp Leu Leu Leu His Leu Met Thr Lys Glu Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser Val His Gly Gly Leu Gln Asn Phe Glu Leu Gln Pro Lys Leu Lys Gln Val Phe Gly Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp Ile Phe Thr Gly Gly Val Asn Thr Gly Val Ile Arg His Val Gly Asp Ala Leu Lys Asp His Ala Ser Lys Ser Arg Gly Lys Ile Cys Thr Ile Gly Ile Ala Pro Trp Gly Ile Val Glu Asn Gln Glu Asp Leu Ile Gly Arg Asp Val Val Arg Pro Tyr Gln Thr Met Ser Asn Pro Met Ser Lys Leu Thr Val Leu Asn Ser Met His Ser His Phe Ile Leu Ala Asp Asn Gly Thr Thr Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Gln Leu Glu Lys His Ile Ser Leu Gln Lys Ile Asn Thr Arg Cys Leu Pro Phe Phe Ser Leu Asp Ser Arg Leu Phe Tyr Ser Phe Trp Gly Ser Cys Gln Leu Asp Ser Val Gly Ile Gly Gln Gly Val Pro Val Val Ala Leu Ile Val Glu Gly Gly Pro Asn Val Ile Ser Ile Val Leu Glu Tyr Leu Arg Asp Thr Pro Pro Val Pro Val Val Val Cys Asp Gly Ser Gly Arg Ala Ser Asp Ile Leu Ala Phe Gly His Lys Tyr Ser Glu Glu Gly Gly Leu Ile Asn Glu Ser Leu Arg Asp Gln Leu Leu Val Thr Ile Gln Lys Thr Phe Thr Tyr Thr Arg Thr Gln Ala Gln His Leu Phe Ile Ile Leu Met Glu Cys Met Lys Lys Lys Glu Leu Ile Thr Val Phe Arg Met Gly Ser Glu Gly His Gln Asp Ile Asp Leu Ala Ile Leu Thr Ala Leu Leu Lys Gly Ala Asn Ala Ser Ala Pro Asp Gln Leu Ser Leu Ala Leu Ala Trp Asn Arg Val Asp Ile Ala Arg Ser Gln Ile Phe Ile Tyr Gly Gln Gln Trp Pro Val Gly Ser Leu Glu Gln Ala Met Leu Asp Ala Leu Val Leu Asp Arg Val Asp Phe Val Lys Leu Leu Ile Glu Asn Gly Val Ser Met His Arg Phe Leu Thr Ile Ser Arg Leu Glu Glu Leu Tyr Asn Thr Arg His Gly Pro Ser Asn Thr Leu Tyr His Leu Val Arg Asp Val Lys Lys Gly Asn Leu Pro Pro Asp Tyr Arg Ile Ser Leu Ile Asp Ile Gly Leu Val Ile Glu Tyr Leu Met Gly Gly Ala Tyr Arg Cys Asn Tyr Thr Arg Lys Arg Phe Arg Thr Leu Tyr His Asn Leu Phe Gly Pro Lys Arg Asp Asp Ile Pro Leu Arg Arg Gly Arg Lys Thr Thr Lys Lys Arg Glu Glu Glu Val Asp Ile Asp Leu Asp Asp Pro Glu Ile Asn His Phe Pro Phe Pro Phe His Glu Leu Met Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala Leu Phe Phe Trp Gln His Gly Glu Glu Ala Met Ala Lys Ala Leu Val Ala Cys Lys Leu Cys Lys Ala Met Ala His Glu Ala Ser Glu Asn Asp Met Val Asp Asp Ile Ser Gln Glu Leu Asn His Asn Ser Arg Asp Phe Gly Gln Leu Ala Val Glu Leu Leu Asp Gln Ser Tyr Lys Gln Asp Glu Gln Leu Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ala Thr Cys Leu Gln Leu Ala Val Ala Ala Lys His Arg Asp Phe Ile Ala His Thr Cys Ser Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg Leu Arg Met Arg Lys Asn Ser Gly Leu Lys Val Ile Leu Gly Ile Leu Leu Pro Pro Ser Ile Leu Ser Leu Glu Phe Lys Asn Lys Asp Asp Met Pro Tyr Met Ser Gln Ala Gln Glu Ile His Leu Gln Glu Lys Glu Ala Glu Glu Pro Glu Lys Pro Thr Lys Glu Lys Glu Glu Glu Asp Met Glu Leu Thr Ala Met Leu Gly Arg Asn Asn Gly Glu Ser Ser Arg Lys Lys Asp Glu Glu Glu Val Gln Ser Lys His Arg Leu Ile Pro Leu Gly Arg Lys Ile Tyr Glu Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Leu Ala Tyr Ile Gly Tyr Leu Met Leu Phe Asn Tyr Ile Val Leu Val Lys Met Glu Arg Trp Pro Ser Thr Gln Glu Trp Ile Val Ile Ser Tyr Ile Phe Thr Leu Gly Ile Glu Lys Met Arg Glu Ile Leu Met Ser Glu Pro Gly Lys Leu Leu Gln Lys Val Lys Val Trp Leu Gln Glu Tyr Trp Asn Val Thr Asp Leu Ile Ala Ile Leu Leu Phe Ser Val Gly Met Ile Leu Arg Leu Gln Asp Gln Pro Phe Arg Ser Asp Gly Arg Val Ile Tyr Cys Val Asn Ile Ile Tyr Trp Tyr Ile Arg Leu Leu Asp Ile Phe Gly Val Asn Lys Tyr Leu Gly Pro Tyr Val Met Met Ile Gly Lys Met Met Ile Asp Met Met Tyr Phe Val Ile Ile Met Leu Val Val Leu Met Ser Phe Gly Val Ala Arg Gln Ala Ile Leu Phe Pro Asn Glu Glu Pro Ser Trp Lys Leu Ala Lys Asn Ile Phe Tyr Met Pro Tyr Trp Met Ile Tyr Gly Glu Val Phe Ala Asp Gln Ile Asp Pro Pro Cys Gly Gln Asn Glu Thr Arg Glu Asp Gly Lys Ile Ile Gln Leu Pro Pro Cys Lys Thr Gly Ala Trp Ile Val Pro Ala Ile Met Ala Cys Tyr Leu Leu Val Ala Asn Ile Leu Leu Val Asn Leu Leu Ile Ala Val Phe Asn Asn Thr Phe Phe Glu Val Lys Ser Ile Ser Asn Gln Val Trp Lys Phe Gln Arg Tyr Gln Leu Ile Met Thr Phe His Glu Arg Pro Val Leu Pro Pro Pro Leu Ile Ile Phe Ser His Met Thr Met Ile Phe Gln His Leu Cys Cys Arg Trp Arg Lys His Glu Ser Asp Pro Asp Glu Arg Asp Tyr Gly Leu Lys Leu Phe Ile Thr Asp Asp Glu Leu Lys Lys Val His Asp Phe Glu Glu Gln Cys Ile Glu Glu Tyr Phe Arg Glu Lys Asp Asp Arg Phe Asn Ser Ser Asn Asp Glu Arg Ile Arg Val Thr Ser Glu Arg Val Glu Asn Met Ser Met Arg Leu Glu Glu Val Asn Glu Arg Glu His Ser Met Lys Ala Ser Leu Gln Thr Val Asp Ile Arg Leu Ala Gln Leu Glu Asp Leu Ile Gly Arg Met Ala Thr Ala Leu Glu Arg Leu Thr Gly Leu Glu Arg Ala Glu Ser Asn Lys Ile Arg Ser Arg Thr Ser Ser Asp Cys Thr Asp Ala Ala Tyr Ile Val Arg Gln Ser Ser Phe Asn Ser Gln Glu Gly Asn Thr Phe Lys Leu Gln Glu Ser Ile Asp Pro Ala Glu His Pro Leu Tyr Ser Val <210> 35 <211> 4710 <212> DNA
<213> homo Sapiens <400> 35 atgtatgtgcgagtatcttttgatacaaaacctgatctcctcttacacctgatgaccaag60 gaatggcagttggagcttcccaagcttctcatctctgtccatgggggcctgcagaacttt120 gaactccagccaaaactcaagcaagtctttgggaaagggctcatcaaagcagcaatgaca180 actggagcgtggatattcactggaggggttaacacaggtgttattcgtcatgttggcgat240 gccttgaaggatcatgcctctaagtctcgaggaaagatatgcaccataggtattgccccc300 tggggaattgtggaaaaccaggaggacctcattggaagagatgttgtccggccataccag360 accatgtccaatcccatgagcaagctcactgttctcaacagcatgcattcccacttcatt420 ctggctgacaacgggaccactggaaaatatggagcagaggtgaaacttcgaagacaactg480 gaaaagcatatttcactccagaagataaacacaagatgcctgccgtttttctctcttgac540 tcccgcttgttttattcattttggggtagttgccagttagactcagttggaatcggtcaa600 ggtgttcctgtggtggcactcatagtggaaggaggacccaatgtgatctcgattgttttg660 gagtaccttcgagacacccctcccgtgccagtggttgtctgtgatgggagtggacgggca720 tcggacatcctggcctttgggcataaatactcagaagaaggcggactgataaatgaatct780 ttgagggaccagctgttggtgactatacagaagactttcacatacactcgaacccaagct840 cagcatctgttcatcatcctcatggagtgcatgaagaagaaggaattgattacggtattt900 cggatgggatcagaaggacaccaggacattgatttggctatcctgacagctttactcaaa960 ggagccaatgcctcggccccagaccaactgagcttagctttagcctggaacagagtcgac1020 atcgctcgcagccagatctttatttacgggcaacagtggccggtgggatctctggagcaa1080 gccatgttggatgccttagttctggacagagtggattttgtgaaattactcatagagaat1140 ggagtaagcatgcaccgttttctcaccatctccagactagaggaattgtacaatacgaga1200 catgggccctcaaatacattgtaccacttggtcagggatgtcaaaaaggggaacctgccc1260 ccagactacagaatcagcctgattgacatcggcctggtgatcgagtacctgatgggcggg1320 gcttatcgctgcaactacacgcgcaagcgcttccggaccctctaccacaacctcttcggc1380 cccaagagggatgatattcccttgaggcgaggaagaaagacaaccaagaaacgtgaagaa1440 gaggtggacattgacttggatgatcctgagatcaaccacttccccttccctttccatgag1500 ctcatggtgtgggctgttctcatgaagcggcagaagatggccctgttcttctggcagcac1560 ggtgaggaggccatggccaaggccctggtggcctgcaagctctgcaaagccatggctcat 1620 gaggcctctgagaacgacatggttgacgacatttcccaggagctgaatcacaattccaga 1680 gactttggccagctggctgtggagctcctggaccagtcctacaagcaggacgaacagctg 1740 gccatgaaactgctgacgtatgagctgaagaactggagcaacgccacgtgcctgcagctt 1800 gccgtggctgccaaacaccgcgacttcatcgcgcacacgtgcagccagatgctgctcacc 1860 gacatgtggatgggccggctccgcatgcgcaagaactcaggcctcaaggtaattctggga 1920 attctacttcctccttcaattctcagcttggagttcaagaacaaagacgacatgccctat 1980 atgtctcaggcccaggaaatccacctccaagagaaggaggcagaagaaccagagaagccc 2040 acaaaggaaaaagaggaagaggacatggagctcacagcaatgttgggacgaaacaacggg 2100 gagtcctccaggaagaaggatgaagaggaagttcagagcaagcaccggttaatccccctc 2160 ggcagaaaaatctatgaattctacaatgcacccatcgtgaagttctggttctacacactg 2220 gcgtatatcggatacctgatgctcttcaactatatcgtgttagtgaagatggaacgctgg 2280 ccgtccacccaggaatggatcgtaatctcctatattttcaccctgggaatagaaaagatg 2340 agagagattctgatgtcagagccagggaagttgctacagaaagtgaaggtatggctgcag 2400 gagtactggaatgtcacggacctcatcgccatccttctgttttctgtcggaatgatcctt 2460 cgtctccaagaccagcccttcaggagtgacgggagggtcatctactgcgtgaacatcatt 2520 tactggtatatccgtctcctagacatcttcggcgtgaacaagtatttgggcccgtatgta 2580 atgatgattggaaaaatgatgatagacatgatgtactttgtcatcattatgctggtggtt 2640 ctgatgagctttggggtcgccaggcaagccatcctttttcccaatgaggagccatcatgg 2700 aaactggccaagaacatcttctacatgccctattggatgatttatggggaagtgtttgcg 2760 gaccagatagaccctccctgtggacagaatgagacccgagaggatggtaaaataatccag 2820 ctgcctccctgcaagacaggagcttggatcgtgccggccatcatggcctgctacctctta 2880 gtggcaaacatcttgctggtcaacctcctcattgctgtctttaacaatacattttttgaa 2940 gtaaaatcgatatccaaccaagtctggaagtttcagaggtatcagctcatcatgactttc 3000 catgaaaggccagttctgcccccaccactgatcatcttcagccacatgaccatgatattc 3060 cagcacctgtgctgccgatggaggaaacacgagagcgacccggatgaaagggactacggc 3120 ctgaaactcttcataaccgatgatgagctcaagaaagtacatgactttgaagagcaatgc 3180 atagaagaatacttcagagaaaaggatgatcggttcaactcatctaatgatgagaggata 3240 cgggtgacttcagaaagggtggagaacatgtctatgcggctggaggaagtcaacgagaga 3300 gagcactccatgaaggcttcactccagaccgtggacatccggctggcgcagctggaagac 3360 cttatcgggcgcatggccacggccctggagcgcctgacaggtctggagcgggccgagtcc 3420 aacaaaatccgctcgaggacctcgtcagactgcacggacgccgcctacattgtccgtcag 3480 agcagcttcaacagccaggaagggaacaccttcaagctccaagagagtatagaccctgca 3540 ggtgaggagaccatgtccccaacttctccaaccttaatgccccgtatgcgaagccattct 3600 ttctattcggtcaatatgaaagacaaaggtggtatagaaaagttggaaagtatttttaaa 3660 gaaaggtccctgagcctacaccgggctactagttcccactctgtagcaaaagaacccaaa 3720 gctcctgcagcccctgccaacaccttggccattgttcctgattccagaagaccatcatcg 3780 tgtatagacatctatgtctctgctatggatgagctccactgtgatatagaccctctggac 3840 aattccgtgaacatccttgggctaggcgagccaagcttttcaactccagtaccttccaca 3900 gccccttcaagtagtgcctatgcaacacttgcacccacagacagacctccaagccggagc 3960 attgattttgaggacatcacctccatggacactagatctttttcttcagactacacccac 4020 ctcccagaatgccaaaacccctgggactcagagcctccgatgtaccacaccattgagcgt 4080 tccaaaagtagccgctacctagccaccacaccctttcttctagaagaggctcccattgtg 4140 aaatctcatagctttatgttttccccctcaaggagctattatgccaactttggggtgcct 4200 gtaaaaacagcagaatacacaagtattacagactgtattgacacaaggtgtgtcaatgcc 4260 cctcaagcaattgcggacagagctgccttccctggaggtcttggagacaaagtggaggac 4320 ttaacttgctgccatccagagcgagaagcagaactgagtcaccccagctctgacagtgag 4380 gagaatgaggccaaaggccgcagagccaccattgcaatatcctcccaggagggtgataac 4440 tcagagagaaccctgtccaacaacatcactgttcccaagatagagcgcgccaacagctac 4500 tcggcagaggagccaagtgcgccatatgcacacaccaggaagagcttctccatcagtgac 4560 aaactcgacaggcagcggaacacagcaagcctgcgaaatcccttccagagaagcaagtcc 4620 tccaagccggagggccgaggggacagcctgtccatgaggaaactgtccagaacatcggct 4680 ttccaaagctttgaaagcaagcacacctaa 4710 <210> 36 <211> 1569 <212> PRT
<213> homo sapiens <400> 36 Met Tyr Val Arg Val Ser Phe Asp Thr Lys Pro Asp Leu Leu Leu His Leu Met Thr Lys Glu Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser Val His Gly Gly Leu Gln Asn Phe Glu Leu Gln Pro Lys Leu Lys Gln Val Phe Gly Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp Ile Phe Thr Gly Gly Val Asn Thr Gly Val Ile Arg His Val Gly Asp Ala Leu Lys Asp His Ala Ser Lys Ser Arg Gly Lys Ile Cys Thr Ile Gly Ile Ala Pro Trp Gly Ile Val Glu Asn Gln Glu Asp Leu Ile Gly Arg Asp Val Val Arg Pro Tyr Gln Thr Met Ser Asn Pro Met Ser Lys Leu Thr Val Leu Asn Ser Met His Ser His Phe Ile Leu Ala Asp Asn Gly Thr Thr Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Gln Leu Glu Lys His Ile Ser Leu Gln Lys Ile Asn Thr Arg Cys Leu Pro Phe Phe Ser Leu Asp Ser Arg Leu Phe Tyr Ser Phe Trp Gly Ser Cys Gln Leu Asp Ser Val Gly Ile Gly Gln Gly Val Pro Val Val Ala Leu Ile Val Glu Gly Gly Pro Asn Val Ile Ser Ile Val Leu Glu Tyr Leu Arg Asp Thr Pro Pro Val Pro Val Val Val Cys Asp Gly Ser Gly Arg Ala Ser Asp Ile Leu Ala Phe Gly His Lys Tyr Ser Glu Glu Gly Gly Leu Ile Asn Glu Ser Leu Arg Asp Gln Leu Leu Val Thr Ile Gln Lys Thr 260 265 ~ 270 Phe Thr Tyr Thr Arg Thr Gln Ala Gln His Leu Phe Ile Ile Leu Met Glu Cys Met Lys Lys Lys Glu Leu Ile Thr Val Phe Arg Met Gly Ser Glu Gly His Gln Asp Ile Asp Leu Ala Ile Leu Thr Ala Leu Leu Lys Gly Ala Asn Ala Ser Ala Pro Asp Gln Leu Ser~Leu Ala Leu Ala Trp Asn Arg Val Asp Ile Ala Arg Ser Gln Ile Phe Ile Tyr Gly Gln Gln Trp Pro Val Gly Ser Leu Glu Gln Ala Met Leu Asp Ala Leu Val Leu Asp Arg Val Asp Phe Val Lys Leu Leu Ile Glu Asn Gly Val Ser Met His Arg Phe Leu Thr Ile Ser Arg Leu Glu Glu Leu Tyr Asn Thr Arg His Gly Pro Ser Asn Thr Leu Tyr His Leu Val Arg Asp Val Lys Lys Gly Asn Leu Pro Pro Asp Tyr Arg Ile Ser Leu Ile Asp Ile Gly Leu Val Ile Glu Tyr Leu Met Gly Gly Ala Tyr Arg Cys Asn Tyr Thr Arg Lys Arg Phe Arg Thr Leu Tyr His Asn Leu Phe Gly Pro Lys Arg Asp Asp Ile Pro Leu Arg Arg Gly Arg Lys Thr Thr Lys Lys Arg Glu Glu Glu Val Asp Ile Asp Leu Asp Asp Pro Glu Ile Asn His Phe Pro Phe Pro Phe His Glu Leu Met Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala Leu Phe Phe Trp Gln His Gly Glu Glu Ala Met Ala Lys Ala Leu Val Ala Cys Lys Leu Cys Lys Ala Met Ala His Glu Ala Ser Glu Asn Asp Met Val Asp Asp Ile Ser Gln Glu Leu Asn His Asn Ser Arg Asp Phe Gly Gln Leu Ala Val Glu Leu Leu Asp Gln Ser Tyr Lys Gln Asp Glu Gln Leu Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ala Thr Cys Leu Gln Leu Ala Val Ala Ala Lys His Arg Asp Phe Ile Ala His Thr Cys Ser Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg Leu Arg Met Arg Lys Asn Ser Gly Leu Lys Val Ile Leu Gly Ile Leu Leu Pro Pro Ser Ile Leu Ser Leu Glu Phe Lys Asn Lys Asp Asp Met Pro Tyr Met Ser Gln Ala Gln Glu Ile His Leu Gln Glu Lys Glu Ala Glu Glu Pro Glu Lys Pro Thr Lys Glu Lys Glu Glu Glu Asp Met Glu Leu Thr Ala Met Leu Gly Arg Asn Asn Gly Glu Ser Ser Arg Lys Lys Asp Glu Glu Glu Val Gln Ser Lys His Arg Leu Ile Pro Leu Gly Arg Lys Ile Tyr Glu Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Leu Ala Tyr Ile Gly Tyr Leu Met Leu Phe Asn Tyr Ile Val Leu Val Lys Met Glu Arg Trp Pro Ser Thr Gln Glu Trp Ile Val Ile Ser Tyr Ile Phe Thr Leu Gly Ile Glu Lys Met Arg Glu Ile Leu Met Ser Glu Pro Gly Lys Leu Leu Gln Lys Val Lys Val Trp Leu Gln Glu Tyr Trp Asn Val Thr Asp Leu Ile Ala Ile Leu Leu Phe Ser Val Gly Met Ile Leu Arg Leu Gln Asp Gln Pro Phe Arg Ser Asp Gly Arg Val Ile Tyr Cys Val Asn Ile Ile Tyr Trp Tyr Ile Arg Leu Leu Asp Ile Phe Gly Val Asn Lys Tyr Leu Gly Pro Tyr Val Met Met Ile Gly Lys Met Met Ile Asp Met Met Tyr Phe Val Ile Ile Met Leu Val Val Leu Met Ser Phe Gly Val Ala Arg Gln Ala Ile Leu Phe Pro Asn Glu Glu Pro Ser Trp Lys Leu Ala Lys Asn Ile Phe Tyr Met Pro Tyr Trp Met Ile Tyr Gly Glu Val Phe Ala Asp Gln Ile Asp Pro Pro Cys Gly Gln Asn Glu Thr Arg Glu Asp Gly Lys Ile Ile Gln Leu Pro Pro Cys Lys Thr Gly Ala Trp Ile Val Pro Ala Ile Met Ala Cys Tyr Leu Leu Val Ala Asn Ile Leu Leu Val Asn Leu Leu Ile Ala Val Phe Asn Asn Thr Phe Phe Glu Val Lys Ser Ile Ser Asn Gln Val Trp Lys Phe Gln Arg Tyr Gln Leu Ile Met Thr Phe His Glu Arg Pro Val Leu Pro Pro Pro Leu Ile Ile Phe Ser His Met Thr Met Ile Phe Gln His Leu Cys Cys Arg Trp Arg Lys His Glu Ser Asp Pro Asp Glu Arg Asp Tyr Gly Leu Lys Leu Phe Ile Thr Asp Asp Glu Leu Lys Lys Val His Asp Phe Glu Glu Gln Cys Ile Glu Glu Tyr Phe Arg Glu Lys Asp Asp Arg Phe Asn Ser Ser Asn Asp Glu Arg Ile Arg Val Thr Ser Glu Arg Val Glu Asn Met Ser Met Arg Leu Glu Glu Val Asn Glu Arg Glu His Ser Met Lys Ala Ser Leu Gln Thr Val Asp Ile Arg Leu Ala Gln Leu Glu Asp Leu Ile Gly Arg Met Ala Thr Ala Leu Glu Arg Leu Thr Gly Leu Glu Arg Ala Glu Ser Asn Lys Ile Arg Ser Arg Thr Ser Ser Asp Cys Thr Asp Ala Ala Tyr Ile Val Arg Gln Ser Ser Phe Asn Ser Gln Glu Gly Asn Thr Phe Lys Leu Gln Glu Ser Ile Asp Pro Ala Gly Glu Glu Thr Met Ser Pro Thr Ser Pro Thr Leu Met Pro Arg Met Arg Ser His Ser Phe Tyr Ser Val Asn Met Lys Asp Lys Gly Gly Ile Glu Lys Leu Glu Ser Ile Phe Lys Glu Arg Ser Leu Ser Leu His Arg Ala Thr Ser Ser His Ser Val Ala Lys Glu Pro Lys Ala Pro Ala Ala Pro Ala Asn Thr Leu Ala Ile Val Pro Asp Ser Arg Arg Pro Ser Ser Cys Ile Asp Ile Tyr Val Ser Ala Met Asp Glu Leu His Cys Asp Ile Asp Pro Leu Asp Asn Ser Val Asn Ile Leu Gly Leu Gly Glu Pro Ser Phe Ser Thr Pro Val Pro Ser Thr Ala Pro Ser Ser Ser Ala Tyr Ala Thr Leu Ala Pro Thr Asp Arg Pro Pro Ser Arg Ser Ile Asp Phe Glu Asp Ile Thr Ser Met Asp Thr Arg Ser Phe Ser Ser Asp Tyr Thr His Leu Pro Glu Cys Gln Asn Pro Trp Asp Ser Glu Pro Pro Met Tyr His Thr Ile Glu Arg Ser Lys Ser Ser Arg Tyr Leu Ala Thr Thr Pro Phe Leu Leu Glu Glu Ala Pro Ile Val Lys Ser His Ser Phe Met Phe Ser Pro Ser Arg Ser Tyr Tyr Ala Asn Phe Gly Val Pro Val Lys Thr Ala Glu Tyr Thr Ser Ile Thr Asp Cys Ile Asp Thr Arg Cys Val Asn Ala Pro Gln Ala Ile Ala Asp Arg Ala Ala Phe Pro Gly Gly Leu Gly Asp Lys Val Glu Asp Leu Thr Cys Cys His Pro Glu Arg Glu Ala Glu Leu Ser His Pro Ser Ser Asp Ser Glu Glu Asn Glu Ala Lys Gly Arg Arg Ala Thr Ile Ala Ile Ser Ser Gln Glu Gly Asp Asn Ser Glu Arg Thr Leu Ser Asn Asn Ile Thr Val Pro Lys Ile Glu Arg Ala Asn Ser Tyr Ser Ala Glu Glu Pro Ser Ala Pro Tyr Ala His Thr Arg Lys Ser Phe Ser Ile Ser Asp Lys Leu Asp Arg Gln Arg Asn Thr Ala Ser Leu Arg Asn Pro Phe Gln Arg Ser Lys Ser Ser Lys Pro Glu Gly Arg Gly Asp Ser Leu Ser Met Arg Lys Leu Ser Arg Thr Ser Ala Phe Gln Ser Phe Glu Ser Lys His Thr <210> 37 <211> 2307 <212> DNA
<213> homo sapiens <400>

atgtatgtgcgagtatcttttgatacaaaacctgatctcctcttacacctgatgaccaag60 gaatggcagttggagcttcccaagcttctcatctctgtccatgggggcctgcagaacttt120 gaactccagccaaaactcaagcaagtctttgggaaagggctcatcaaagcagcaatgaca180 actggagcgtggatattcactggaggggttaacacaggtgttattcgtcatgttggcgat240 gccttgaaggatcatgcctctaagtctcgaggaaagatatgcaccataggtattgccccc300 tggggaattgtggaaaaccaggaggacctcattggaagagatgttgtccggccataccag360 accatgtccaatcccatgagcaagctcactgttctcaacagcatgcattcccacttcatt420 ctggctgacaacgggaccactggaaaatatggagcagaggtgaaacttcgaagacaactg480 gaaaagcatatttcactccagaagataaacacaagaatcggtcaaggtgttcctgtggtg540 gcactcatagtggaaggaggacccaatgtgatctcgattgttttggagtaccttcgagac600 acccctcccgtgccagtggttgtctgtgatgggagtggacgggcatcggacatcctggcc660 tttgggcataaatactcagaagaaggcggactgataaatgaatctttgagggaccagctg720 ttggtgactatacagaagactttcacatacactcgaacccaagctcagcatctgttcatc780 atcctcatggagtgcatgaagaagaaggaattgattacggtatttcggatgggatcagaa840 ggacaccaggacattgatttggctatcctgacagctttactcaaaggagccaatgcctcg900 gccccagaccaactgagcttagctttagcctggaacagagtcgacatcgctcgcagccag960 atctttatttacgggcaacagtggccggtgggatctctggagcaagccatgttggatgcc1020 ttagttctggacagagtggattttgtgaaattactcatagagaatggagtaagcatgcac1080 cgttttctcaccatctccagactagaggaattgtacaatacgagacatgggccctcaaat1140 acattgtaccacttggtcagggatgtcaaaaaggggaacctgcccccagactacagaatc1200 agcctgattgacatcggcctggtgatcgagtacctgatgggcggggcttatcgctgcaac1260 tacacgcgcaagcgcttccggaccctctaccacaacctcttcggccccaagagggatgat1320 attcccttgaggcgaggaagaaagacaaccaagaaacgtgaagaagaggtggacattgac1380 ttggatgatcctgagatcaaccacttccccttccctttccatgagctcatggtgtgggct1440 gttctcatgaagcggcagaagatggccctgttcttctggcagcacggtgaggaggccatg1500 gccaaggccctggtggcctgcaagctctgcaaagccatggctcatgaggcctctgagaac1560 gacatggttgacgacatttcccaggagctgaatcacaattccagagactttggccagctg1620 gctgtggagctcctggaccagtcctacaagcaggacgaacagctggccatgaaactgctg1680 acgtatgagctgaagaactggagcaacgccacgtgcctgcagcttgccgtggctgccaaa1740 caccgcgacttcatcgcgcacacgtgcagccagatgctgctcaccgacatgtggatgggc1800 cggctccgcatgcgcaagaactcaggcctcaaggtaattctgggaattctacttcctcct1860 tcaattctcagcttggagttcaagaacaaagacgacatgccctatatgtctcaggcccag1920 gaaatccacctccaagagaaggaggcagaagaaccagagaagcccacaaaggaaaaagag1980 gaagaggacatggagctcacagcaatgttgggacgaaacaacggggagtcctccaggaag2040 aaggatgaagaggaagttcagagcaagcaccggttaatccccctcggcagaaaaatctat2100 gaattctacaatgcacccatcgtgaagttctggttctacacactggcgtatatcggatac2160 ctgatgctcttcaactatatcgtgttagtgaagatggaacgctggccgtccacccaggaa2220 tggatcgtaatctcctatattttcacccttgttccagctggttgtctgcacttcggtctt2280 cccattcatggtgccttttcttcttga 2307 <210> 38 <211> 768 <212> PRT
<213> homo sapiens <400> 38 Met Tyr Val Arg Val Ser Phe Asp Thr Lys Pro Asp Leu Leu Leu His Leu Met Thr Lys Glu Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser Val His Gly Gly Leu Gln Asn Phe Glu Leu Gln Pro Lys Leu Lys Gln Val Phe Gly Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp Ile Phe Thr Gly Gly Val Asn Thr Gly Val Ile Arg His Val Gly Asp Ala Leu Lys Asp His Ala Ser Lys Ser Arg Gly Lys Ile Cys Thr Ile Gly Ile Ala Pro Trp Gly Ile Val Glu Asn Gln Glu Asp Leu Ile Gly Arg Asp Val Val Arg Pro Tyr Gln Thr Met Ser Asn Pro Met Ser Lys Leu Thr Val Leu Asn Ser Met His Ser His Phe Ile Leu Ala Asp Asn Gly Thr Thr Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Gln Leu Glu Lys His Ile Ser Leu Gln Lys Ile Asn Thr Arg Ile Gly Gln Gly Val Pro Val Val Ala Leu Ile Val Glu Gly Gly Pro Asn Val Ile Ser Ile Val Leu Glu Tyr Leu Arg Asp Thr Pro Pro Val Pro Val Val Val Cys Asp Gly Ser Gly Arg Ala Ser Asp Ile Leu Ala Phe Gly His Lys Tyr Ser Glu Glu Gly Gly Leu Ile Asn Glu Ser Leu Arg Asp Gln Leu Leu Val Thr Ile Gln Lys Thr Phe Thr Tyr Thr Arg Thr Gln Ala Gln His Leu Phe Ile Ile Leu Met Glu Cys Met Lys Lys Lys Glu Leu Ile Thr Val Phe Arg Met Gly Ser Glu Gly His Gln Asp Ile Asp Leu Ala Ile Leu Thr Ala Leu Leu Lys Gly Ala Asn Ala Ser Ala Pro Asp Gln Leu Ser Leu Ala Leu Ala Trp Asn Arg Val Asp Ile Ala Arg Ser Gln Ile Phe Ile Tyr Gly Gln Gln Trp Pro Val Gly Ser Leu Glu Gln Ala Met Leu Asp Ala Leu Val Leu Asp Arg Val Asp Phe Val Lys Leu Leu Ile Glu Asn Gly Val Ser Met His Arg Phe Leu Thr Ile Ser Arg Leu Glu Glu Leu Tyr Asn Thr Arg His Gly Pro Ser Asn Thr Leu Tyr His Leu Val Arg Asp Val Lys Lys Gly Asn Leu Pro Pro Asp Tyr Arg Ile Ser Leu Ile Asp Ile Gly Leu Val Ile Glu Tyr Leu Met Gly Gly Ala Tyr Arg Cys Asn Tyr Thr Arg Lys Arg Phe Arg Thr Leu Tyr His Asn Leu Phe Gly Pro Lys Arg Asp Asp Ile Pro Leu Arg Arg Gly Arg Lys Thr Thr Lys Lys Arg Glu Glu Glu Val Asp Ile Asp Leu Asp Asp Pro Glu Ile Asn His Phe Pro Phe Pro Phe His Glu Leu Met Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala Leu Phe Phe Trp Gln His Gly Glu Glu Ala Met Ala Lys Ala Leu Val Ala Cys Lys Leu Cys Lys Ala Met Ala His Glu Ala Ser Glu Asn Asp Met Val Asp Asp Ile Ser Gln Glu Leu Asn His Asn Ser Arg Asp Phe Gly Gln Leu Ala Val Glu Leu Leu Asp Gln Ser Tyr Lys Gln Asp Glu Gln Leu Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ala Thr Cys Leu Gln Leu Ala Val Ala Ala Lys His Arg Asp Phe Ile Ala His Thr Cys Ser Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg Leu Arg Met Arg Lys Asn Ser Gly Leu Lys Val Ile Leu Gly Ile Leu Leu Pro Pro Ser Ile Leu Ser Leu Glu Phe Lys Asn Lys Asp Asp Met Pro Tyr Met Ser Gln Ala Gln Glu Ile His Leu Gln Glu Lys Glu Ala Glu Glu Pro Glu Lys Pro Thr Lys Glu Lys Glu Glu Glu Asp Met Glu Leu Thr Ala Met Leu Gly Arg Asn Asn Gly Glu Ser Ser Arg Lys Lys Asp Glu Glu Glu Val Gln Ser Lys His Arg Leu Ile Pro Leu Gly Arg Lys Ile Tyr Glu Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Leu Ala Tyr Ile Gly Tyr Leu Met Leu Phe Asn Tyr Ile Val Leu Val Lys Met Glu Arg Trp Pro Ser Thr Gln Glu Trp Ile Val Ile Ser Tyr Ile Phe Thr Leu Val Pro Ala Gly Cys Leu His Phe Gly Leu Pro Ile His Gly Ala Phe Ser Ser <210> 39 <211> 2367 <212> DNA
<213> homo sapiens <400> 39 atgtatgtgcgagtatcttttgatacaaaacctgatctcctcttacacctgatgaccaag60 gaatggcagttggagcttcccaagcttctcatctctgtccatgggggcctgcagaacttt120 gaactccagccaaaactcaagcaagtctttgggaaagggctcatcaaagcagcaatgaca180 actggagcgtggatattcactggaggggttaacacaggtgttattcgtcatgttggcgat240 gccttgaaggatcatgcctctaagtctcgaggaaagatatgcaccataggtattgccccc300 tggggaattgtggaaaaccaggaggacctcattggaagagatgttgtccggccataccag360 accatgtccaatcccatgagcaagctcactgttctcaacagcatgcattcccacttcatt420 ctggctgacaacgggaccactggaaaatatggagcagaggtgaaacttcgaagacaactg480 gaaaagcatatttcactccagaagataaacacaagaatcggtcaaggtgttcctgtggtg540 gcactcatagtggaaggaggacccaatgtgatctcgattgttttggagtaccttcgagac600 acccctcccgtgccagtggttgtctgtgatgggagtggacgggcatcggacatcctggcc660 tttgggcataaatactcagaagaaggcggactgataaatgaatctttgagggaccagctg720 ttggtgactatacagaagactttcacatacactcgaacccaagctcagcatctgttcatc780 atcctcatggagtgcatgaagaagaaggaattgattacggtatttcggatgggatcagaa840 ggacaccaggacattgatttggctatcctgacagctttactcaaaggagccaatgcctcg900 gccccagaccaactgagcttagctttagcctggaacagagtcgacatcgctcgcagccag960 atctttatttacgggcaacagtggccggtgggatctctggagcaagccatgttggatgcc1020 ttagttctggacagagtggattttgtgaaattactcatagagaatggagtaagcatgcac1080 cgttttctcaccatctccagactagaggaattgtacaatacgagacatgggccctcaaat1140 acattgtaccacttggtcagggatgtcaaaaaggggaacctgcccccagactacagaatc1200 agcctgattgacatcggcctggtgatcgagtacctgatgggcggggcttatcgctgcaac1260 tacacgcgcaagcgcttccggaccctctaccacaacctcttcggccccaagagggatgat1320 attcccttgaggcgaggaagaaagacaaccaagaaacgtgaagaagaggtggacattgac1380 ttggatgatcctgagatcaaccacttccccttccctttccatgagctcatggtgtgggct1440 gttctcatgaagcggcagaagatggccctgttcttctggcagcacggtgaggaggccatg1500 gccaaggccctggtggcctgcaagctctgcaaagccatggctcatgaggcctctgagaac1560 gacatggttgacgacatttcccaggagctgaatcacaattccagagactttggccagctg1620 gctgtggagctcctggaccagtcctacaagcaggacgaacagctggccatgaaactgctg1680 acgtatgagctgaagaactggagcaacgccacgtgcctgcagcttgccgtggctgccaaa1740 caccgcgacttcatcgcgcacacgtgcagccagatgctgctcaccgacatgtggatgggc1800 cggctccgcatgcgcaagaactcaggcctcaaggtaattctgggaattctacttcctcct1860 tcaattctcagcttggagttcaagaacaaagacgacatgccctatatgtctcaggcccag1920 gaaatccacctccaagagaaggaggcagaagaaccagagaagcccacaaaggaaaaagag1980 gaagaggacatggagctcacagcaatgttgggacgaaacaacggggagtcctccaggaag2040 aaggatgaagaggaagttcagagcaagcaccggttaatccccctcggcagaaaaatctat2100 gaattctacaatgcacccatcgtgaagttctggttctacacactggcgtatatcggatac2160 ctgatgctcttcaactatatcgtgttagtgaagatggaacgctggccgtccacccaggaa2220 tggatcgtaatctcctatattttcaccctgggaatagaaaagatgagagaggtaacggct2280 tttataaaagaaaacgtaagagaaagacagtggttaagttctatctgtggatggagggga2340 caggaagatgcctgggatgcaaattaa 2367 <210> 40 <211> 788 <212> PRT
<213> homo Sapiens <400> 40 Met Tyr Val Arg Val Ser Phe Asp Thr Lys Pro Asp Leu Leu Leu His Leu Met Thr Lys Glu Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser Val His Gly Gly Leu Gln Asn Phe Glu Leu Gln Pro Lys Leu Lys Gln Val Phe Gly Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp Ile Phe Thr Gly Gly Val Asn Thr Gly Val Ile Arg His Val Gly Asp Ala Leu Lys Asp His Ala Ser Lys Ser Arg Gly Lys Ile Cys Thr Ile Gly Ile Ala Pro Trp Gly Ile Val Glu Asn Gln Glu Asp Leu Ile Gly Arg Asp Val Val Arg Pro Tyr Gln Thr Met Ser Asn Pro Met Ser Lys Leu Thr Val Leu Asn Ser Met His Ser His Phe Ile Leu Ala Asp Asn Gly Thr Thr Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Gln Leu Glu Lys His Ile Ser Leu Gln Lys Ile Asn Thr Arg Ile Gly Gln Gly Val Pro Val Val Ala Leu Ile Val Glu Gly Gly Pro Asn Val Ile Ser Ile Val Leu Glu Tyr Leu Arg Asp Thr Pro Pro Val Pro Val Val Val Cys Asp Gly Ser Gly Arg Ala Ser Asp Ile Leu Ala Phe Gly His Lys Tyr Ser Glu Glu Gly Gly Leu Ile Asn Glu Ser Leu Arg Asp Gln Leu Leu Val Thr Ile Gln Lys Thr Phe Thr Tyr Thr Arg Thr Gln Ala Gln His Leu Phe Ile Ile Leu Met Glu Cys Met Lys Lys Lys Glu Leu Ile Thr Val Phe Arg Met Gly Ser Glu Gly His Gln Asp Ile Asp Leu Ala Ile Leu Thr Ala Leu Leu Lys Gly Ala Asn Ala Ser Ala Pro Asp Gln Leu Ser Leu Ala Leu Ala Trp Asn Arg Val Asp Ile Ala Arg Ser Gln Ile Phe Ile Tyr Gly Gln Gln Trp Pro Val Gly Ser Leu Glu Gln Ala Met Leu Asp Ala Leu Val Leu Asp Arg Val Asp Phe Val Lys Leu Leu Ile Glu Asn Gly Val Ser Met His Arg Phe Leu Thr Ile Ser Arg Leu Glu Glu Leu Tyr Asn Thr Arg His Gly Pro Ser Asn Thr Leu Tyr His Leu Val Arg Asp Val Lys Lys Gly Asn Leu Pro Pro Asp Tyr Arg Ile Ser Leu Ile Asp Ile Gly Leu Val Ile Glu Tyr Leu Met Gly Gly Ala Tyr Arg Cys Asn Tyr Thr Arg Lys Arg Phe Arg Thr Leu Tyr His Asn Leu Phe Gly Pro Lys Arg Asp Asp Ile Pro Leu Arg Arg Gly Arg Lys Thr Thr Lys Lys Arg Glu Glu Glu Val Asp Ile Asp Leu Asp Asp Pro Glu Ile Asn His Phe Pro Phe Pro Phe His Glu Leu Met Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala Leu Phe Phe Trp Gln His Gly Glu Glu Ala Met Ala Lys Ala Leu Val Ala Cys Lys Leu Cys Lys Ala Met Ala His Glu Ala Ser Glu Asn Asp Met Val Asp Asp Ile Ser Gln Glu Leu Asn His Asn Ser Arg Asp Phe Gly Gln Leu Ala Val Glu Leu Leu Asp Gln Ser Tyr Lys Gln Asp Glu Gln Leu Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ala Thr Cys Leu Gln Leu Ala Val Ala Ala Lys His Arg Asp Phe Ile Ala His Thr Cys Ser Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg Leu Arg Met Arg Lys Asn Ser Gly Leu Lys Val Ile Leu Gly Ile Leu Leu Pro Pro Ser Ile Leu Ser Leu Glu Phe Lys Asn Lys Asp Asp Met Pro Tyr Met Ser Gln Ala Gln Glu Ile His Leu Gln Glu Lys Glu Ala Glu Glu Pro Glu Lys Pro Thr Lys Glu Lys Glu Glu Glu Asp Met Glu Leu Thr Ala Met Leu Gly Arg Asn Asn Gly Glu Ser Ser Arg Lys Lys Asp Glu Glu Glu Val Gln Ser Lys His Arg Leu Ile Pro Leu Gly Arg Lys Ile Tyr Glu Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Leu Ala Tyr Ile Gly Tyr Leu Met Leu Phe Asn Tyr Ile Val Leu Val Lys Met Glu Arg Trp Pro Ser Thr Gln Glu Trp Ile Val Ile Ser Tyr Ile Phe Thr Leu Gly Ile Glu Lys Met Arg Glu Val Thr Ala Phe Ile Lys Glu Asn Val Arg Glu Arg Gln Trp Leu Ser Ser Ile Cys Gly Trp Arg Gly Gln Glu Asp Ala Trp Asp Ala Asn <210> 41 <211> 2742 <212> DNA
<213> homo sapiens <400>

atgtatgtgcgagtatcttttgatacaaaacctgatctcctcttacacctgatgaccaag60 gaatggcagttggagcttcccaagcttctcatctctgtccatgggggcctgcagaacttt120 gaactccagccaaaactcaagcaagtctttgggaaagggctcatcaaagcagcaatgaca180 actggagcgtggatattcactggaggggttaacacaggtgttattcgtcatgttggcgat240 gccttgaaggatcatgcctctaagtctcgaggaaagatatgcaccataggtattgccccc300 tggggaattgtggaaaaccaggaggacctcattggaagagatgttgtccggccataccag360 accatgtccaatcccatgagcaagctcactgttctcaacagcatgcattcccacttcatt420 ctggctgacaacgggaccactggaaaatatggagcagaggtgaaacttcgaagacaactg480 gaaaagcatatttcactccagaagataaacacaagaatcggtcaaggtgttcctgtggtg540 gcactcatagtggaaggaggacccaatgtgatctcgattgttttggagtaccttcgagac600 acccctcccgtgccagtggttgtctgtgatgggagtggacgggcatcggacatcctggcc660 tttgggcataaatactcagaagaaggcggactgataaatgaatctttgagggaccagctg720 ttggtgactatacagaagactttcacatacactcgaacccaagctcagcatctgttcatc780 atcctcatggagtgcatgaagaagaaggaattgattacggtatttcggatgggatcagaa840 ggacaccaggacattgatttggctatcctgacagctttactcaaaggagccaatgcctcg900 gccccagaccaactgagcttagctttagcctggaacagagtcgacatcgctcgcagccag960 atctttatttacgggcaacagtggccggtgggatctctggagcaagccatgttggatgcc1020 ttagttctggacagagtggattttgtgaaattactcatagagaatggagtaagcatgcac1080 cgttttctcaccatctccagactagaggaattgtacaatacgagacatgggccctcaaat1140 acattgtaccacttggtcagggatgtcaaaaaggggaacctgcccccagactacagaatc1200 agcctgattgacatcggcctggtgatcgagtacctgatgggcggggcttatcgctgcaac1260 tacacgcgcaagcgcttccggaccctctaccacaacctcttcggccccaagagggatgat1320 attcccttgaggcgaggaagaaagacaaccaagaaacgtgaagaagaggtggacattgac1380 ttggatgatcctgagatcaaccacttccccttccctttccatgagctcatggtgtgggct1440 gttctcatgaagcggcagaagatggccctgttcttctggcagcacggtgaggaggccatg1500 gccaaggccctggtggcctgcaagctctgcaaagccatggctcatgaggcctctgagaac1560 gacatggttgacgacatttcccaggagctgaatcacaattccagagactttggccagctg1620 gctgtggagctcctggaccagtcctacaagcaggacgaacagctggccatgaaactgctg1680 acgtatgagctgaagaactggagcaacgccacgtgcctgcagcttgccgtggctgccaaa1740 caccgcgacttcatcgcgcacacgtgcagccagatgctgctcaccgacatgtggatgggc1800 cggctccgcatgcgcaagaactcaggcctcaaggtaattctgggaattctacttcctcct1860 tcaattctcagcttggagttcaagaacaaagacgacatgccctatatgtctcaggcccag1920 gaaatccacctccaagagaaggaggcagaagaaccagagaagcccacaaaggaaaaagag1980 gaagaggacatggagctcacagcaatgttgggacgaaacaacggggagtcctccaggaag2040 aaggatgaagaggaagttcagagcaagcaccggttaatccccctcggcagaaaaatctat2100 gaattctacaatgcacccatcgtgaagttctggttctacacactggcgtatatcggatac2160 ctgatgctcttcaactatatcgtgttagtgaagatggaacgctggccgtccacccaggaa2220 tggatcgtaatctcctatattttcaccctgggaatagaaaagatgagagagattctgatg2280 tcagagccagggaagttgctacagaaagtgaaggtatggctgcaggagtactggaatgtc2340 acggacctcatcgccatccttctgttttctgtcggaatgatccttcgtctccaagaccag_2400 cccttcaggagtgacgggagggtcatctactgcgtgaacatcatttactggtatatccgt2460 ctcctagacatcttcggcgtgaacaagtatttgggcccgtatgtaatgatgattggaaaa2520 atgatgatagacatgatgtactttgtcatcattatgctggtggttctgatgagctttggg2580 gtcgccaggcaagccatcctttttcccaatgaggagccatcatggaaactggccaagaac2640 atcttctacatgccctattggatgatttatggggaagtgtttgcggaccagatagaccgt2700 aagcaagtttatgattctcatacaccaaagtcaggtatttas 2742 <210> 42 <211> 913 <212> PRT
<213> homo sapiens <400> 42 Met Tyr Val Arg Val Ser Phe Asp Thr Lys Pro Asp Leu Leu Leu His Leu Met Thr Lys Glu Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser Val His Gly Gly Leu Gln Asn Phe Glu Leu Gln Pro Lys Leu Lys Gln Val Phe Gly Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp Ile Phe Thr Gly Gly Val Asn Thr Gly Val Ile Arg His Val Gly Asp Ala Leu Lys Asp His Ala Ser Lys Ser Arg Gly Lys Ile Cys Thr Ile Gly Ile Ala Pro Trp Gly Ile Val Glu Asn Gln Glu Asp Leu Ile Gly Arg Asp Val Val Arg Pro Tyr Gln Thr Met Ser Asn Pro Met Ser Lys Leu Thr Val Leu Asn Ser Met His Ser His Phe Ile Leu Ala Asp Asn Gly Thr Thr Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Gln Leu Glu Lys His Ile Ser Leu Gln Lys Ile Asn Thr Arg Ile Gly Gln Gly Val Pro Val Val Ala Leu Ile Val Glu Gly Gly Pro Asn Val Ile Ser Ile Val Leu Glu Tyr Leu Arg Asp Thr Pro Pro Val Pro Val Val Val Cys Asp Gly Ser Gly Arg Ala Ser Asp Ile Leu Ala Phe Gly His Lys Tyr Ser Glu Glu Gly Gly Leu Ile Asn Glu Ser Leu Arg Asp Gln Leu Leu Val Thr Ile Gln Lys Thr Phe Thr Tyr Thr Arg Thr Gln Ala Gln His Leu Phe Ile Ile Leu Met Glu Cys Met Lys Lys Lys Glu Leu Ile Thr Val Phe Arg Met Gly Ser Glu Gly His Gln Asp Ile Asp Leu Ala Ile Leu Thr Ala Leu Leu Lys Gly Ala Asn Ala Ser Ala Pro Asp Gln Leu Ser Leu Ala Leu Ala Trp Asn Arg Val Asp Ile Ala Arg Ser Gln Ile Phe Ile Tyr Gly Gln Gln Trp Pro Val Gly Ser Leu Glu Gln Ala Met Leu Asp Ala Leu Val Leu Asp Arg Val Asp Phe Val Lys Leu Leu Ile Glu Asn Gly Val Ser Met His Arg Phe Leu Thr Ile Ser Arg Leu Glu Glu Leu Tyr Asn Thr Arg His Gly Pro Ser Asn Thr Leu Tyr His Leu Val Arg Asp Val Lys Lys Gly Asn Leu Pro Pro Asp Tyr Arg Ile Ser Leu Ile Asp Ile Gly Leu Val Ile Glu Tyr Leu Met Gly Gly Ala Tyr Arg Cys Asn Tyr Thr Arg Lys Arg Phe Arg Thr Leu Tyr His Asn Leu Phe Gly Pro Lys Arg Asp Asp Ile Pro Leu Arg Arg Gly Arg Lys Thr Thr Lys Lys Arg Glu Glu Glu Val Asp Ile Asp Leu Asp Asp Pro Glu Ile Asn His Phe Pro Phe Pro Phe His Glu Leu Met Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala Leu Phe Phe Trp Gln His Gly Glu Glu Ala Met Ala Lys Ala Leu Val Ala Cys Lys Leu Cys Lys Ala Met Ala His Glu Ala Ser Glu Asn Asp Met Val Asp Asp Ile Ser Gln Glu Leu Asn His Asn Ser Arg Asp Phe Gly Gln Leu Ala Val Glu Leu Leu Asp Gln Ser Tyr Lys Gln Asp Glu Gln Leu Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ala Thr Cys Leu Gln Leu Ala Val Ala Ala Lys His Arg Asp Phe Ile Ala His Thr Cys Ser Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg Leu Arg Met Arg Lys Asn Ser Gly Leu Lys Val Ile Leu Gly Ile Leu Leu Pro Pro Ser Ile Leu Ser Leu Glu Phe Lys Asn Lys Asp Asp Met Pro Tyr Met Ser Gln Ala Gln Glu Ile His Leu Gln Glu Lys Glu Ala Glu Glu Pro Glu Lys Pro Thr Lys Glu Lys Glu Glu Glu Asp Met Glu Leu Thr Ala Met Leu Gly Arg Asn Asn Gly Glu Ser Ser Arg Lys Lys Asp Glu Glu Glu Val Gln Ser Lys His Arg Leu Ile Pro Leu Gly Arg Lys Ile Tyr Glu Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Leu Ala Tyr Ile Gly Tyr Leu Met Leu Phe Asn Tyr Ile Val Leu Val Lys Met Glu Arg Trp Pro Ser Thr Gln Glu Trp Ile Val Ile Ser Tyr Ile Phe Thr Leu Gly Ile Glu Lys Met Arg Glu Ile Leu Met Ser Glu Pro Gly Lys Leu Leu Gln Lys Val Lys Val Trp Leu Gln Glu Tyr Trp Asn Val Thr Asp Leu Ile Ala Ile Leu Leu Phe Ser Val Gly Met Ile Leu Arg Leu Gln Asp Gln Pro Phe Arg Ser Asp Gly Arg Val Ile Tyr Cys Val Asn Ile Ile Tyr Trp Tyr Ile Arg Leu Leu Asp Ile Phe Gly Val Asn Lys Tyr Leu Gly Pro Tyr Val Met Met Ile Gly Lys Met Met Ile Asp Met Met Tyr Phe Val Ile Ile Met Leu Val Val Leu Met Ser Phe Gly Val Ala Arg Gln Ala Ile Leu Phe Pro Asn Glu Glu Pro Ser Trp Lys Leu Ala Lys Asn Ile Phe Tyr Met Pro Tyr Trp Met Ile Tyr Gly Glu Val Phe Ala Asp Gln Ile Asp Arg Lys Gln Val Tyr Asp Ser His Thr Pro Lys Ser Gly Ile <210> 43 <211> 3300 <212> DNA
<213> homo sapiens <400>

atgtatgtgcgagtatcttttgatacaaaacctgatctcctcttacacctgatgaccaag60 gaatggcagttggagcttcccaagcttctcatctctgtccatgggggcctgcagaacttt120 gaactccagccaaaactcaagcaagtctttgggaaagggctcatcaaagcagcaatgaca180 actggagcgtggatattcactggaggggttaacacaggtgttattcgtcatgttggcgat240 gccttgaaggatcatgcctctaagtctcgaggaaagatatgcaccataggtattgccccc300 tggggaattgtggaaaaccaggaggacctcattggaagagatgttgtccggccataccag360 accatgtccaatcccatgagcaagctcactgttctcaacagcatgcattcccacttcatt420 ctggctgacaacgggaccactggaaaatatggagcagaggtgaaacttcgaagacaactg480 gaaaagcatatttcactccagaagataaacacaagaatcggtcaaggtgttcctgtggtg540 gcactcatagtggaaggaggacccaatgtgatctcgattgttttggagtaccttcgagac600 acccctcccgtgccagtggttgtctgtgatgggagtggacgggcatcggacatcctggcc660 tttgggcataaatactcagaagaaggcggactgataaatgaatctttgagggaccagctg720 ttggtgactatacagaagactttcacatacactcgaacccaagctcagcatctgttcatc780 atcctcatggagtgcatgaagaagaaggaattgattacggtatttcggatgggatcagaa840 ggacaccaggacattgatttggctatcctgacagctttactcaaaggagccaatgcctcg900 gccccagaccaactgagcttagctttagcctggaacagagtcgacatcgctcgcagccag960 atctttatttacgggcaacagtggccggtgggatctctggagcaagccatgttggatgcc1020 ttagttctggacagagtggattttgtgaaattactcatagagaatggagtaagcatgcac1080 cgttttctcaccatctccagactagaggaattgtacaatacgagacatgggccctcaaat1140 acattgtaccacttggtcagggatgtcaaaaaggggaacctgcccccagactacagaatc1200 agcctgattgacatcggcctggtgatcgagtacctgatgggcggggcttatcgctgcaac1260 tacacgcgcaagcgcttccggaccctctaccacaacctcttcggccccaagagggatgat1320 attcccttgaggcgaggaagaaagacaaccaagaaacgtgaagaagaggtggacattgac1380 ttggatgatcctgagatcaaccacttccccttccctttccatgagctcatggtgtgggct1440 gttctcatgaagcggcagaagatggccctgttcttctggcagcacggtgaggaggccatg1500 gccaaggccctggtggcctgcaagctctgcaaagccatggctcatgaggcctctgagaac1560 gacatggttgacgacatttcccaggagctgaatcacaattccagagactttggccagctg1620 gctgtggagctcctggaccagtcctacaagcaggacgaacagctggccatgaaactgctg1680 acgtatgagctgaagaactggagcaacgccacgtgcctgcagcttgccgtggctgccaaa1740 caccgcgacttcatcgcgcacacgtgcagccagatgctgctcaccgacatgtggatgggc1800 cggctccgcatgcgcaagaactcaggcctcaaggtaattctgggaattctacttcctcct1860 tcaattctcagcttggagttcaagaacaaagacgacatgccctatatgtctcaggcccag1920 gaaatccacctccaagagaaggaggcagaagaaccagagaagcccacaaaggaaaaagag1980 gaagaggacatggagctcacagcaatgttgggacgaaacaacggggagtcctccaggaag2040 aaggatgaagaggaagttcagagcaagcaccggttaatccccctcggcagaaaaatctat2100 gaattctacaatgcacccatcgtgaagttctggttctacacactggcgtatatcggatac2160 ctgatgctcttcaactatatcgtgttagtgaagatggaacgctggccgtccacccaggaa2220 tggatcgtaatctcctatattttcaccctgggaatagaaaagatgagagagattctgatg2280 tcagagccagggaagttgctacagaaagtgaaggtatggctgcaggagtactggaatgtc2340 acggacctcatcgccatccttctgttttctgtcggaatgatccttcgtctccaagaccag2400 cccttcaggagtgacgggagggtcatctactgcgtgaacatcatttactggtatatccgt2460 ctcctagacatcttcggcgtgaacaagtatttgggcccgtatgtaatgatgattggaaaa2520 atgatgatagacatgatgtactttgtcatcattatgctggtggttctgatgagctttggg2580 gtcgccaggcaagccatcctttttcccaatgaggagccatcatggaaactggccaagaac2640 atcttctacatgccctattggatgatttatggggaagtgtttgcggaccagatagaccct2700 ccctgtggacagaatgagacccgagaggatggtaaaataatccagctgcctccctgcaag2760 acaggagcttggatcgtgccggccatcatggcctgctacctcttagtggcaaacatcttg2820 ctggtcaacctcctcattgctgtctttaacaatacattttttgaagtaaaatcgatatcc2880 aaccaagtctggaagtttcagaggtatcagctcatcatgactttccatgaaaggccagtt2940 ctgcccccaccactgatcatcttcagccacatgaccatgatattccagcacctgtgctgc3000 cgatggaggaaacacgagagcgacccggatgaaagggactacggcctgaaactcttcata3060 accgatgatgagctcaagaaagtacatgactttgaagagcaatgcatagaagaatacttc3120 agagaaaaggatgatcggttcaactcatctaatgatgagaggatacgggtgacttcagaa3180 aggtgtgttctgtggacacctgcctcctgcagatgtgttgtgccaaggcatgctttatcc3240 atcgaatttattcacacggtcacaaaacagagatcttttgtgtttgtttttattgtctga3300 <210> 44 <211> 1099 <212> PRT
<213> homo sapiens <400> 44 Met Tyr Val Arg Val Ser Phe Asp Thr Lys Pro Asp Leu Leu Leu His Leu Met Thr Lys Glu Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser Val His Gly Gly Leu Gln Asn Phe Glu Leu Gln Pro Lys Leu Lys Gln Val Phe Gly Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp Ile Phe Thr Gly Gly Val Asn Thr Gly Val Ile Arg His Val Gly Asp Ala Leu Lys Asp His Ala Ser Lys Ser Arg Gly Lys Ile Cys Thr Ile Gly Ile Ala Pro Trp Gly Ile Val Glu Asn Gln Glu Asp Leu Ile Gly Arg Asp Val Val Arg Pro Tyr Gln Thr Met Ser Asn Pro Met Ser Lys Leu Thr Val Leu Asn Ser Met His Ser His Phe Ile Leu Ala Asp Asn Gly Thr Thr Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Gln Leu Glu Lys His Ile Ser Leu Gln Lys Ile Asn Thr Arg Ile Gly Gln Gly Val Pro Val Val Ala Leu Ile Val Glu Gly Gly Pro Asn Val Ile Ser Ile Val Leu Glu Tyr Leu Arg Asp Thr Pro Pro Val Pro Val Val Val Cys Asp Gly Ser Gly Arg Ala Ser Asp Ile Leu Ala Phe Gly His Lys Tyr Ser Glu Glu Gly Gly Leu Ile Asn Glu Ser Leu Arg Asp Gln Leu Leu Val Thr Ile Gln Lys Thr Phe Thr Tyr Thr Arg Thr Gln Ala Gln His Leu Phe Ile Ile Leu Met Glu Cys Met Lys Lys Lys Glu Leu Ile Thr Val Phe Arg Met Gly Ser Glu Gly His Gln Asp Ile Asp Leu Ala Ile Leu Thr Ala Leu Leu Lys Gly Ala Asn Ala Ser Ala Pro Asp Gln Leu Ser Leu Ala Leu Ala Trp Asn Arg Val Asp Ile Ala Arg Ser Gln Ile Phe Ile Tyr Gly Gln Gln Trp Pro Val Gly Ser Leu Glu Gln Ala Met Leu Asp Ala Leu Val Leu Asp Arg Val Asp Phe Val Lys Leu Leu Ile Glu Asn Gly Val Ser Met His Arg Phe Leu Thr Ile Ser Arg Leu Glu Glu Leu Tyr Asn Thr Arg His Gly Pro Ser Asn Thr Leu Tyr His Leu Val Arg Asp Val Lys Lys Gly Asn Leu Pro Pro Asp Tyr Arg Ile Ser Leu Ile Asp Ile Gly Leu Val Ile Glu Tyr Leu Met Gly Gly Ala Tyr Arg Cys Asn Tyr Thr Arg Lys Arg Phe Arg Thr Leu Tyr His Asn Leu Phe Gly Pro Lys Arg Asp Asp Ile Pro Leu Arg Arg Gly Arg Lys Thr Thr Lys Lys Arg Glu Glu Glu Val Asp Ile Asp Leu Asp Asp Pro Glu Ile Asn His Phe Pro Phe Pro Phe His Glu Leu Met Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala Leu Phe Phe Trp Gln His Gly Glu Glu Ala Met Ala Lys Ala Leu Val Ala Cys Lys Leu Cys Lys Ala Met Ala His Glu Ala Ser Glu Asn Asp Met Val Asp Asp Ile Ser Gln Glu Leu Asn His Asn Ser Arg Asp Phe Gly Gln Leu Ala Val Glu Leu Leu Asp Gln Ser Tyr Lys Gln Asp Glu Gln Leu Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ala Thr Cys Leu Gln Leu Ala Val Ala Ala Lys His Arg Asp Phe Ile Ala His Thr Cys Ser Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg Leu Arg Met Arg Lys Asn Ser Gly Leu Lys Val Ile Leu Gly Ile Leu Leu Pro Pro Ser Ile Leu Ser Leu Glu Phe Lys Asn Lys Asp Asp Met Pro Tyr Met Ser Gln Ala Gln Glu Ile His Leu Gln Glu Lys Glu Ala Glu Glu Pro Glu Lys Pro Thr Lys Glu Lys Glu Glu Glu Asp Met Glu Leu Thr Ala Met Leu Gly Arg Asn Asn Gly Glu Ser Ser Arg Lys Lys Asp Glu Glu Glu Val Gln Ser Lys His Arg Leu Ile Pro Leu Gly Arg Lys Ile Tyr Glu Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Leu Ala Tyr Ile Gly Tyr Leu Met Leu Phe Asn Tyr Ile Val Leu Val Lys Met Glu Arg Trp Pro Ser Thr Gln Glu Trp Ile Val Ile Ser Tyr Ile Phe Thr Leu Gly Ile Glu Lys Met Arg Glu Ile Leu Met Ser Glu Pro Gly Lys Leu Leu Gln Lys Val Lys Val Trp Leu Gln Glu Tyr Trp Asn Val Thr Asp Leu Ile Ala Ile Leu Leu Phe Ser Val Gly Met Ile Leu Arg Leu Gln Asp Gln Pro Phe Arg Ser Asp Gly Arg Val Ile Tyr Cys Val Asn Ile Ile Tyr Trp Tyr Ile Arg Leu Leu Asp Ile Phe Gly Val Asn Lys Tyr Leu Gly Pro Tyr Val Met Met Ile Gly Lys Met Met Ile Asp Met Met Tyr Phe Val Ile Ile Met Leu Val Val Leu Met Ser Phe Gly Val Ala Arg Gln Ala Ile Leu Phe Pro Asn Glu Glu Pro Ser Trp Lys Leu Ala Lys Asn Ile Phe Tyr Met Pro Tyr Trp Met Ile Tyr Gly Glu Val Phe Ala Asp Gln Ile Asp Pro Pro Cys Gly Gln Asn Glu Thr Arg Glu Asp Gly Lys Ile Ile Gln Leu Pro Pro Cys Lys Thr Gly Ala Trp Ile Val Pro Ala Ile Met Ala Cys Tyr Leu Leu Val Ala Asn Ile Leu Leu Val Asn Leu Leu Ile Ala Val Phe Asn Asn Thr Phe Phe Glu Val Lys Ser Ile Ser Asn Gln Val Trp Lys Phe Gln Arg Tyr Gln Leu Ile Met Thr Phe His Glu Arg Pro Val Leu Pro Pro Pro Leu Ile Ile Phe Ser His Met Thr Met Ile Phe Gln His Leu Cys Cys Arg Trp Arg Lys His Glu Ser Asp Pro Asp Glu Arg Asp Tyr Gly Leu Lys Leu Phe Ile Thr Asp Asp Glu Leu Lys Lys Val His Asp Phe Glu Glu Gln Cys Ile Glu Glu Tyr Phe Arg Glu Lys Asp Asp Arg Phe Asn Ser Ser Asn Asp Glu Arg Ile Arg Val Thr Ser Glu Arg Cys Val Leu Trp Thr Pro Ala Ser Cys Arg Cys Val Val Pro Arg His Ala Leu Ser Ile Glu Phe Ile His Thr Val Thr Lys Gln Arg Ser Phe Val Phe Val Phe Ile Val <210> 45 <211> 3489 <212> DNA
<213> homo Sapiens <400>

atgtatgtgcgagtatcttttgatacaaaacctgatctcctcttacacctgatgaccaag 60 gaatggcagttggagcttcccaagcttctcatctctgtccatgggggcctgcagaacttt 120 gaactccagccaaaactcaagcaagtctttgggaaagggctcatcaaagcagcaatgaca 180 actggagcgtggatattcactggaggggttaacacaggtgttattcgtcatgttggcgat 240 gccttgaaggatcatgcctctaagtctcgaggaaagatatgcaccataggtattgccccc 300 tggggaattgtggaaaaccaggaggacctcattggaagagatgttgtccggccataccag 360 accatgtccaatcccatgagcaagctcactgttctcaacagcatgcattcccacttcatt 420 ctggctgacaacgggaccactggaaaatatggagcagaggtgaaacttcgaagacaactg 480 gaaaagcatatttcactccagaagataaacacaagaatcggtcaaggtgttcctgtggtg 540 gcactcatagtggaaggaggacccaatgtgatctcgattgttttggagtaccttcgagac 600 acccctcccgtgccagtggttgtctgtgatgggagtggacgggcatcggacatcctggcc 660 tttgggcataaatactcagaagaaggcggactgataaatgaatctttgagggaccagctg 720 ttggtgactatacagaagactttcacatacactcgaacccaagctcagcatctgttcatc 780 atcctcatggagtgcatgaagaagaaggaattgattacggtatttcggatgggatcagaa 840 ggacaccaggacattgatttggctatcctgacagctttactcaaaggagccaatgcctcg 900 gccccagaccaactgagcttagctttagcctggaacagagtcgacatcgctcgcagccag 960 atctttatttacgggcaacagtggccggtgggatctctggagcaagccatgttggatgcc 1020 ttagttctggacagagtggattttgtgaaattactcatagagaatggagtaagcatgcac 1080 cgttttctcaccatctccagactagaggaattgtacaatacgagacatgggccctcaaat 1140 acattgtaccacttggtcagggatgtcaaaaaggggaacctgcccccagactacagaatc 1200 agcctgattgacatcggcctggtgatcgagtacctgatgggcggggcttatcgctgcaac 1260 tacacgcgcaagcgcttccggaccctctaccacaacctcttcggccccaagagggatgat 1320 attcccttgaggcgaggaagaaagacaaccaagaaacgtgaagaagaggtggacattgac 1380 ttggatgatcctgagatcaaccacttccccttccctttccatgagctcatggtgtgggct 1440 gttctcatgaagcggcagaagatggccctgttcttctggcagcacggtgaggaggccatg 1500 gccaaggccctggtggcctgcaagctctgcaaagccatggctcatgaggcctctgagaac 1560 gacatggttgacgacatttcccaggagctgaatcacaattccagagactttggccagctg 1620 gctgtggagctcctggaccagtcctacaagcaggacgaacagctggccatgaaactgctg 1680 acgtatgagctgaagaactggagcaacgccacgtgcctgcagcttgccgtggctgccaaa 1740 caccgcgacttcatcgcgcacacgtgcagccagatgctgctcaccgacatgtggatgggc 1800 cggctccgcatgcgcaagaactcaggcctcaaggtaattctgggaattctacttcctcct 1860 tcaattctcagcttggagttcaagaacaaagacgacatgccctatatgtctcaggcccag 1920 gaaatccacctccaagagaaggaggcagaagaaccagagaagcccacaaaggaaaaagag 1980 gaagaggacatggagctcacagcaatgttgggacgaaacaacggggagtcctccaggaag 2040 aaggatgaagaggaagttcagagcaagcaccggttaatccccctcggcagaaaaatctat 2100 gaattctacaatgcacccatcgtgaagttctggttctacacactggcgtatatcggatac 2160 ctgatgctcttcaactatatcgtgttagtgaagatggaacgctggccgtccacccaggaa 2220 tggatcgtaatctcctatattttcaccctgggaatagaaaagatgagagagattctgatg 2280 tcagagccagggaagttgctacagaaagtgaaggtatggctgcaggagtactggaatgtc 2340 acggacctcatcgccatccttctgttttctgtcggaatgatccttcgtctccaagaccag 2400 cccttcaggagtgacgggagggtcatctactgcgtgaacatcatttactggtatatccgt 2460 ctcctagacatcttcggcgtgaacaagtatttgggcccgtatgtaatgatgattggaaaa 2520 atgatgatagacatgatgtactttgtcatcattatgctggtggttctgatgagctttggg 2580 gtcgccaggcaagccatcctttttcccaatgaggagccatcatggaaactggccaagaac 2640 atcttctacatgccctattggatgatttatggggaagtgtttgcggaccagatagaccct 2700 ccctgtggacagaatgagacccgagaggatggtaaaataatccagctgcctccctgcaag 2760 acaggagcttggatcgtgccggccatcatggcctgctacctcttagtggcaaacatcttg 2820 ctggtcaacctcctcattgctgtctttaacaatacattttttgaagtaaaatcgatatcc 2880 aaccaagtctggaagtttcagaggtatcagctcatcatgactttccatgaaaggccagtt 2940 ctgcccccaccactgatcatcttcagccacatgaccatgatattccagcacctgtgctgc 3000 cgatggaggaaacacgagagcgacccggatgaaagggactacggcctgaaactcttcata 3060 accgatgatgagctcaagaaagtacatgactttgaagagcaatgcatagaagaatacttc 3120 agagaaaaggatgatcggttcaactcatctaatgatgagaggatacgggtgacttcagaa 3180 agggtggagaacatgtctatgcggctggaggaagtcaacgagagagagcactccatgaag 3240 gcttcactccagaccgtggacatccggctggcgcagctggaagaccttatcgggcgcatg 3300 gccacggccctggagcgcct.gacaggtctggagcgggccgagtccaacaaaatccgctcg 3360 aggacctcgtcagactgcacggacgccgcctacattgtccgtcagagcagcttcaacagc 3420 caggaaggga acaccttcaa gctccaagag agtatagacc ctgcagagca tcctctttat 3480 tcagtataa 3489 <210> 46 <211> 1162 <212> PRT
<213> homo sapiens <400> 46 Met Tyr Val Arg Val Ser Phe Asp Thr Lys Pro Asp Leu Leu Leu His Leu Met Thr Lys Glu Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser Val His Gly Gly Leu Gln Asn Phe Glu Leu Gln Pro Lys Leu Lys Gln Val Phe Gly Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp Ile Phe Thr Gly Gly Val Asn Thr Gly Val Ile Arg His Val Gly Asp Ala Leu Lys Asp His Ala Ser Lys Ser Arg Gly Lys Ile Cys Thr Ile Gly Ile Ala Pro Trp Gly Ile Val Glu Asn Gln Glu Asp Leu Ile Gly Arg Asp Val Val Arg Pro Tyr Gln Thr Met Ser Asn Pro Met Ser Lys Leu Thr Val Leu Asn Ser Met His Ser His Phe Ile Leu Ala Asp Asn Gly Thr Thr Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Gln Leu Glu Lys His Ile Ser Leu Gln Lys Ile Asn Thr Arg Ile Gly Gln Gly Val Pro Val Val Ala Leu Ile Val Glu Gly Gly Pro Asn Val Ile Ser Ile Val Leu Glu Tyr Leu Arg Asp Thr Pro Pro Val Pro Val Val Val Cys Asp Gly Ser Gly Arg Ala Ser Asp Ile Leu Ala Phe Gly His Lys Tyr Ser Glu Glu Gly Gly Leu Ile Asn Glu Ser Leu Arg Asp Gln Leu Leu Val Thr Ile Gln Lys Thr Phe Thr Tyr Thr Arg Thr Gln Ala Gln His Leu Phe Ile Ile Leu Met Glu Cys Met Lys Lys Lys Glu Leu Ile Thr Val Phe Arg Met Gly Ser Glu Gly His Gln Asp Ile Asp Leu Ala Ile Leu Thr Ala Leu Leu Lys Gly Ala Asn Ala Ser Ala Pro Asp Gln Leu Ser Leu Ala Leu Ala Trp Asn Arg Val Asp Ile Ala Arg Ser Gln Ile Phe Ile Tyr Gly Gln Gln Trp Pro Val Gly Ser Leu Glu Gln Ala Met Leu Asp Ala Leu Val Leu Asp Arg Val Asp Phe Val Lys Leu Leu Ile Glu Asn Gly Val Ser Met His Arg Phe Leu Thr Ile Ser Arg Leu Glu Glu Leu Tyr Asn Thr Arg His Gly Pro Ser Asn Thr Leu Tyr His Leu Val Arg Asp Val Lys Lys Gly Asn Leu Pro Pro Asp Tyr Arg Ile Ser Leu Ile Asp Ile Gly Leu Val Ile Glu Tyr Leu Met Gly Gly Ala Tyr Arg Cys Asn Tyr Thr Arg Lys Arg Phe Arg Thr Leu Tyr His Asn Leu Phe Gly Pro Lys Arg Asp Asp Ile Pro Leu Arg Arg Gly Arg Lys Thr Thr Lys Lys Arg Glu Glu Glu Val Asp Ile Asp Leu Asp Asp Pro Glu Ile Asn His Phe Pro Phe Pro Phe His Glu Leu Met Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala Leu Phe Phe Trp Gln His Gly Glu Glu Ala Met Ala Lys Ala Leu Val Ala Cys Lys Leu Cys Lys Ala Met Ala His Glu Ala Ser Glu Asn Asp Met Val Asp Asp Ile Ser Gln Glu Leu Asn His Asn Ser Arg Asp Phe Gly Gln Leu Ala Val Glu Leu Leu Asp Gln Ser Tyr Lys Gln Asp Glu Gln Leu Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ala Thr Cys Leu Gln Leu Ala Val Ala Ala Lys His Arg Asp Phe Ile Ala His Thr Cys Ser Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg Leu Arg Met Arg Lys Asn Ser Gly Leu Lys Val Ile Leu Gly Ile Leu Leu Pro Pro Ser Ile Leu Ser Leu Glu Phe Lys Asn Lys Asp Asp Met Pro Tyr Met Ser Gln Ala Gln Glu Ile His Leu Gln Glu Lys Glu Ala Glu Glu Pro Glu Lys Pro Thr Lys Glu Lys Glu Glu Glu Asp Met Glu Leu Thr Ala Met Leu Gly Arg Asn Asn Gly Glu Ser Ser Arg Lys Lys Asp Glu Glu Glu Val Gln Ser Lys His Arg Leu Ile Pro Leu Gly Arg Lys Ile Tyr Glu Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Leu Ala Tyr Ile Gly Tyr Leu Met Leu Phe Asn Tyr Ile Val Leu Val Lys Met Glu Arg Trp Pro Ser Thr Gln Glu Trp Ile Val Ile Ser Tyr Ile Phe Thr Leu Gly Ile Glu Lys Met Arg Glu Ile Leu Met Ser Glu Pro Gly Lys Leu Leu Gln Lys Val Lys Val Trp Leu Gln Glu Tyr Trp Asn Val Thr Asp Leu Ile Ala Ile Leu Leu Phe Ser Val Gly Met Ile Leu Arg Leu Gln Asp Gln Pro Phe Arg Ser Asp Gly Arg Val Ile Tyr Cys Val Asn Ile Ile Tyr Trp Tyr Ile Arg Leu Leu Asp Ile Phe Gly Val Asn Lys Tyr Leu Gly Pro Tyr Val Met Met Ile Gly Lys Met Met Ile Asp Met Met Tyr Phe Val Ile Ile Met Leu Val Val Leu Met Ser Phe Gly Val Ala Arg Gln Ala Ile Leu Phe Pro Asn Glu Glu Pro Ser Trp Lys Leu Ala Lys Asn Ile Phe Tyr Met Pro Tyr Trp Met Ile Tyr Gly Glu Val Phe Ala Asp Gln Ile Asp Pro Pro Cys Gly Gln Asn Glu Thr Arg Glu Asp Gly Lys Ile Ile Gln Leu Pro Pro Cys Lys Thr Gly Ala Trp Ile Val Pro Ala Ile Met Ala Cys Tyr Leu Leu Val Ala Asn Ile Leu Leu Val Asn Leu Leu Ile Ala Val Phe Asn Asn Thr Phe Phe Glu Val Lys Ser Ile Ser Asn Gln Val Trp Lys Phe Gln Arg Tyr Gln Leu Ile Met Thr Phe His Glu Arg Pro Val Leu Pro Pro Pro Leu Ile Ile Phe Ser His Met Thr Met Ile Phe Gln His Leu Cys Cys Arg Trp Arg Lys His Glu Ser Asp Pro Asp Glu Arg Asp Tyr Gly Leu Lys Leu Phe Ile Thr Asp Asp Glu Leu Lys Lys Val His Asp Phe Glu Glu Gln Cys Ile Glu Glu Tyr Phe Arg Glu Lys Asp Asp Arg Phe Asn Ser Ser Asn Asp Glu Arg Ile Arg Val Thr Ser Glu Arg Val Glu Asn Met Ser Met Arg Leu Glu Glu Val Asn Glu Arg Glu His Ser Met Lys Ala Ser Leu Gln Thr Val Asp Ile Arg Leu Ala Gln Leu Glu Asp Leu Ile Gly Arg Met Ala Thr Ala Leu Glu Arg Leu Thr Gly Leu Glu Arg Ala Glu Ser Asn Lys Ile Arg Ser Arg Thr Ser Ser Asp Cys Thr Asp Ala Ala Tyr Ile Val Arg Gln Ser Ser Phe Asn Ser Gln Glu Gly Asn Thr Phe Lys Leu Gln Glu Ser Ile Asp Pro Ala Glu His Pro Leu Tyr Ser Val <210> 47 <211> 4635 <212> DNA
<213> homo sapiens <400>

atgtatgtgcgagtatcttttgatacaaaacctgatctcctcttacacctgatgaccaag 60 gaatggcagttggagcttcccaagcttctcatctctgtccatgggggcctgcagaacttt 120 gaactccagccaaaactcaagcaagtctttgggaaagggctcatcaaagcagcaatgaca 180 actggagcgtggatattcactggaggggttaacacaggtgttattcgtcatgttggcgat 240 gccttgaaggatcatgcctctaagtctcgaggaaagatatgcaccataggtattgccccc 300 tggggaattgtggaaaaccaggaggacctcattggaagagatgttgtccggccataccag 360 accatgtccaatcccatgagcaagctcactgttctcaacagcatgcattcccacttcatt 420 ctggctgacaacgggaccactggaaaatatggagcagaggtgaaacttcgaagacaactg 480 gaaaagcatatttcactccagaagataaacacaagaatcggtcaaggtgttcctgtggtg 540 gcactcatagtggaaggaggacccaatgtgatctcgattgttttggagtaccttcgagac 600 acccctcccgtgccagtggttgtctgtgatgggagtggacgggcatcggacatcctggcc 660 tttgggcataaatactcagaagaaggcggactgataaatgaatctttgagggaccagctg 720 ttggtgactatacagaagactttcacatacactcgaacccaagctcagcatctgttcatc 780 atcctcatggagtgcatgaagaagaaggaattgattacggtatttcggatgggatcagaa 840 ggacaccaggacattgatttggctatcctgacagctttactcaaaggagccaatgcctcg 900 gccccagaccaactgagcttagctttagcctggaacagagtcgacatcgctcgcagccag 960 atctttatttacgggcaacagtggccggtgggatctctggagcaagccatgttggatgcc 1020 ttagttctggacagagtggattttgtgaaattactcatagagaatggagtaagcatgcac 1080 cgttttctcaccatctccagactagaggaattgtacaatacgagacatgggccctcaaat 1140 acattgtaccacttggtcagggatgtcaaaaaggggaacctgcccccagactacagaatc 1200 agcctgattgacatcggcctggtgatcgagtacctgatgggcggggcttatcgctgcaac 1260 tacacgcgcaagcgcttccggaccctctaccacaacctcttcggccccaagagggatgat 1320 attcccttgaggcgaggaagaaagacaaccaagaaacgtgaagaagaggtggacattgac 1380 ttggatgatcctgagatcaaccacttccccttccctttccatgagctcatggtgtgggct 1440 gttctcatgaagcggcagaagatggccctgttcttctggcagcacggtgaggaggccatg 1500 gccaaggccctggtggcctgcaagctctgcaaagccatggctcatgaggcctctgagaac 1560 gacatggttgacgacatttcccaggagctgaatcacaattccagagactttggccagctg 1620 gctgtggagctcctggaccagtcctacaagcaggacgaacagctggccatgaaactgctg 1680 acgtatgagctgaagaactggagcaacgccacgtgcctgcagcttgccgtggctgccaaa 1740 caccgcgacttcatcgcgcacacgtgcagccagatgctgctcaccgacatgtggatgggc 1800 cggctccgcatgcgcaagaactcaggcctcaaggtaattctgggaattctacttcctcct 1860 tcaattctcagcttggagttcaagaacaaagacgacatgccctatatgtctcaggcccag 1920 gaaatccacctccaagagaaggaggcagaagaaccagagaagcccacaaaggaaaaagag 1980 gaagaggacatggagctcacagcaatgttgggacgaaacaacggggagtcctccaggaag 2040 aaggatgaagaggaagttcagagcaagcaccggttaatccccctcggcagaaaaatctat 2100 gaattctacaatgcacccatcgtgaagttctggttctacacactggcgtatatcggatac 2160 ctgatgctcttcaactatatcgtgttagtgaagatggaacgctggccgtccacccaggaa 2220 tggatcgtaatctcctatattttcaccctgggaatagaaaagatgagagagattctgatg 2280 tcagagccagggaagttgctacagaaagtgaaggtatggctgcaggagtactggaatgtc 2340 acggacctcatcgccatccttctgttttctgtcggaatgatccttcgtctccaagaccag 2400 cccttcaggagtgacgggagggtcatctactgcgtgaacatcatttactggtatatccgt 2460 ctcctagacatcttcggcgtgaacaagtatttgggcccgtatgtaatgatgattggaaaa 2520 atgatgatagacatgatgtactttgtcatcattatgctggtggttctgatgagctttggg 2580 gtcgccaggcaagccatcctttttcccaatgaggagccatcatggaaactggccaagaac 2640 atcttctacatgccctattggatgatttatggggaagtgtttgcggaccagatagaccct 2700 ccctgtggacagaatgagacccgagaggatggtaaaataatccagctgcctccctgcaag 2760 acaggagcttggatcgtgccggccatcatggcctgctacctcttagtggcaaacatcttg 2820 ctggtcaacctcctcattgctgtctttaacaatacattttttgaagtaaaatcgatatcc 2880 aaccaagtctggaagtttcagaggtatcagctcatcatgactttccatgaaaggccagtt 2940 ctgcccccaccactgatcatcttcagccacatgaccatgatattccagcacctgtgctgc 3000 cgatggaggaaacacgagagcgacccggatgaaagggactacggcctgaaactcttcata 3060 accgatgatgagctcaagaaagtacatgactttgaagagcaatgcatagaagaatacttc 3120 agagaaaaggatgatcggttcaactcatctaatgatgagaggatacgggtgacttcagaa 3180 agggtggagaacatgtctatgcggctggaggaagtcaacgagagagagcactccatgaag 3240 gcttcactccagaccgtggacatccggctggcgcagctggaagaccttatcgggcgcatg 3300 gccacggccctggagcgcctgacaggtctggagcgggccgagtccaacaaaatccgctcg 3360 aggacctcgtcagactgcacggacgccgcctacattgtccgtcagagcagcttcaacagc 3420 caggaagggaacaccttcaagctccaagagagtatagaccctgcaggtgaggagaccatg 3480 tccccaacttctccaaccttaatgccccgtatgcgaagccattctttctattcggtcaat 3540 atgaaagacaaaggtggtatagaaaagttggaaagtatttttaaagaaaggtccctgagc 3600 ctacaccgggctactagttcccactctgtagcaaaagaacccaaagctcctgcagcccct 3660 gccaacaccttggccattgttcctgattccagaagaccatcatcgtgtatagacatctat 3720 gtctctgctatggatgagctccactgtgatatagaccctctggacaattccgtgaacatc 3780 cttgggctaggcgagccaagcttttcaactccagtaccttccacagccccttcaagtagt 3840 gcctatgcaacacttgcacccacagacagacctccaagccggagcattgattttgaggac 3900 atcacctccatggacactagatctttttcttcagactacacccacctcccagaatgccaa 3960 aacccctgggactcagagcctccgatgtaccacaccattgagcgttccaaaagtagccgc 4020 tacctagccaccacaccctttcttctagaagaggctcccattgtgaaatctcatagcttt 4080 atgttttccccctcaaggagctattatgccaactttggggtgcctgtaaaaacagcagaa 4140 tacacaagtattacagactgtattgacacaaggtgtgtcaatgcccctcaagcaattgcg 4200 gacagagctgccttccctggaggtcttggagacaaagtggaggacttaacttgctgccat 4260 ccagagcgagaagcagaactgagtcaccccagctctgacagtgaggagaatgaggccaaa 4320 ggccgcagagccaccattgcaatatcctcccaggagggtgataactcagagagaaccctg 4380 tccaacaacatcactgttcccaagatagagcgcgccaacagctactcggcagaggagcca 4440 agtgcgccatatgcacacaccaggaagagcttctccatcagtgacaaactcgacaggcag 4500 cggaacacagcaagcctgcgaaatcccttccagagaagcaagtcctccaagccggagggc 4560 cgaggggacagcctgtccatgaggaaactgtccagaacatcggctttccaaagctttgaa 4620 agcaagcacacctaa 4635 <210> 48 <211> 1544 <212> PRT
<213> homo Sapiens <400> 48 Met Tyr Val Arg Val Ser Phe Asp Thr Lys Pro Asp Leu Leu Leu His Leu Met Thr Lys Glu Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser Val His Gly Gly Leu Gln Asn Phe Glu Leu Gln Pro Lys Leu Lys Gln Val Phe Gly Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp Ile Phe Thr Gly Gly Val Asn Thr Gly Val Ile Arg His Val Gly Asp Ala Leu Lys Asp His Ala Ser Lys Ser Arg Gly Lys Ile Cys Thr Ile Gly Ile Ala Pro Trp Gly Ile Val Glu Asn Gln Glu Asp Leu Ile Gly Arg Asp Val Val Arg Pro Tyr Gln Thr Met Ser Asn Pro Met Ser Lys Leu Thr Val Leu Asn Ser Met His Ser His Phe Ile Leu Ala Asp Asn Gly Thr Thr Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Gln Leu Glu Lys His Ile Ser Leu Gln Lys Ile Asn Thr Arg Ile Gly Gln Gly Val Pro Val Val Ala Leu Ile Val Glu Gly Gly Pro Asn Val Ile Ser Ile Val Leu Glu Tyr Leu Arg Asp Thr Pro Pro Val Pro Val Val Val Cys Asp Gly Ser Gly Arg Ala Ser Asp Ile Leu Ala Phe Gly His Lys Tyr Ser Glu Glu Gly Gly Leu Ile Asn Glu Ser Leu Arg Asp Gln Leu Leu Val Thr Ile Gln Lys Thr Phe Thr Tyr Thr Arg Thr Gln Ala Gln His Leu Phe Ile Ile Leu Met Glu Cys Met Lys Lys Lys Glu Leu Ile Thr Val Phe Arg Met Gly Ser Glu Gly His Gln Asp Ile Asp Leu Ala Ile Leu Thr Ala Leu Leu Lys Gly Ala Asn Ala Ser Ala Pro Asp Gln Leu Ser Leu Ala Leu Ala Trp Asn Arg Val Asp Ile Ala Arg Ser Gln Ile Phe Ile Tyr Gly Gln Gln Trp Pro Val Gly Ser Leu Glu Gln Ala Met Leu Asp Ala Leu Val Leu Asp Arg Val Asp Phe Val Lys Leu Leu Ile Glu Asn Gly Val Ser Met His Arg Phe Leu Thr Ile Ser Arg Leu Glu Glu Leu Tyr Asn Thr Arg His Gly Pro Ser Asn Thr Leu Tyr His Leu Val Arg Asp Val Lys Lys Gly Asn Leu Pro Pro Asp Tyr Arg Ile Ser Leu Ile Asp Ile Gly Leu Val Ile Glu Tyr Leu Met Gly Gly Ala Tyr Arg Cys Asn Tyr Thr Arg Lys Arg Phe Arg Thr Leu Tyr His Asn Leu Phe Gly Pro Lys Arg Asp Asp Ile Pro Leu Arg Arg Gly Arg Lys Thr Thr Lys Lys Arg Glu Glu Glu Val Asp Ile Asp Leu Asp Asp Pro Glu Ile Asn His Phe Pro Phe Pro Phe His Glu Leu Met Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala Leu Phe Phe Trp Gln His Gly Glu Glu Ala Met Ala Lys Ala Leu Val Ala Cys Lys Leu Cys Lys Ala Met Ala His Glu Ala Ser Glu Asn Asp Met Val Asp Asp Ile Ser Gln Glu Leu Asn His Asn Ser Arg Asp Phe Gly Gln Leu Ala Val Glu Leu Leu Asp Gln Ser Tyr Lys Gln Asp Glu Gln Leu Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ala Thr Cys Leu Gln Leu Ala Val Ala Ala Lys His Arg Asp Phe Ile Ala His Thr Cys Ser Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg Leu Arg Met Arg Lys Asn Ser Gly Leu Lys Val Ile Leu Gly Ile Leu Leu Pro Pro Ser Ile Leu Ser Leu Glu Phe Lys Asn Lys Asp Asp Met Pro Tyr Met Ser Gln Ala Gln Glu Ile His Leu Gln Glu Lys Glu Ala Glu Glu Pro Glu Lys Pro Thr Lys Glu Lys Glu Glu Glu Asp Met Glu Leu Thr Ala Met Leu Gly Arg Asn Asn Gly Glu Ser Ser Arg Lys Lys Asp Glu Glu Glu Val Gln Ser Lys His Arg Leu Ile Pro Leu Gly Arg Lys Ile Tyr Glu Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Leu Ala Tyr Ile Gly Tyr Leu Met Leu Phe Asn Tyr Ile Val Leu Val Lys Met Glu Arg Trp Pro Ser Thr Gln Glu Trp Ile Val Ile Ser Tyr Ile Phe Thr Leu Gly Ile Glu Lys Met Arg Glu Ile Leu Met Ser Glu Pro Gly Lys Leu Leu Gln Lys Val Lys Val Trp Leu Gln Glu Tyr Trp Asn Val Thr Asp Leu Ile Ala Ile Leu Leu Phe Ser Val Gly Met Ile Leu Arg Leu Gln Asp Gln Pro Phe Arg Ser Asp Gly Arg Val Ile Tyr Cys Val Asn Ile Ile Tyr Trp Tyr Ile Arg Leu Leu Asp Ile Phe Gly Val Asn Lys Tyr Leu Gly Pro Tyr Val Met Met Ile Gly Lys Met Met Ile Asp Met Met Tyr Phe Val Ile Ile Met Leu Val Val Leu Met Ser Phe Gly Val Ala Arg Gln Ala Ile Leu Phe Pro Asn Glu Glu Pro Ser Trp Lys Leu Ala Lys Asn Ile Phe Tyr Met Pro Tyr Trp Met Ile Tyr Gly Glu Val Phe Ala Asp Gln Ile Asp Pro Pro Cys Gly Gln Asn Glu Thr Arg Glu Asp Gly Lys Ile Ile Gln Leu Pro Pro Cys Lys Thr Gly Ala Trp Ile Val Pro Ala Ile Met Ala Cys Tyr Leu Leu Val Ala Asn Ile Leu Leu Val Asn Leu Leu Ile Ala Val Phe Asn Asn Thr Phe Phe Glu Val Lys Ser Ile Ser Asn Gln Val Trp Lys Phe Gln Arg Tyr Gln Leu Ile Met Thr Phe His Glu Arg Pro Val Leu Pro Pro Pro Leu Ile Ile Phe Ser His Met Thr Met Ile Phe Gln His Leu Cys Cys Arg Trp Arg Lys His Glu Ser Asp Pro Asp Glu Arg Asp Tyr Gly Leu Lys Leu Phe Ile Thr Asp Asp Glu Leu Lys Lys Val His Asp Phe Glu Glu Gln Cys Ile Glu Glu Tyr Phe Arg Glu Lys Asp Asp Arg Phe Asn Ser Ser Asn Asp Glu Arg Ile Arg Val Thr Ser Glu Arg Val Glu Asn Met Ser Met Arg Leu Glu Glu Val Asn Glu Arg Glu His Ser Met Lys Ala Ser Leu Gln Thr Val Asp Ile Arg Leu Ala Gln Leu Glu Asp Leu Ile Gly Arg Met Ala Thr Ala Leu Glu Arg Leu Thr Gly Leu Glu Arg Ala Glu Ser Asn Lys Ile Arg Ser Arg Thr Ser Ser Asp Cys Thr Asp Ala Ala Tyr Ile Val Arg Gln Ser Ser Phe Asn Ser Gln Glu Gly Asn Thr Phe Lys Leu Gln Glu Ser Ile Asp Pro Ala Gly Glu Glu Thr Met Ser Pro Thr Ser Pro Thr Leu Met Pro Arg Met Arg Ser His Ser Phe Tyr Ser Val Asn Met Lys Asp Lys Gly Gly Ile Glu Lys Leu Glu Ser Ile Phe Lys Glu Arg Ser Leu Ser Leu His Arg Ala Thr Ser Ser His Ser Val Ala Lys Glu Pro Lys Ala Pro Ala Ala Pro Ala Asn Thr Leu Ala Ile Val Pro Asp Ser Arg Arg Pro Ser Ser Cys Ile Asp Ile Tyr Val Ser Ala Met Asp Glu Leu His Cys Asp Ile Asp Pro Leu Asp Asn Ser Val Asn Ile Leu Gly Leu Gly Glu Pro Ser Phe Ser Thr Pro Val Pro Ser Thr Ala Pro Ser Ser Ser Ala Tyr Ala Thr Leu Ala Pro Thr Asp Arg Pro Pro Ser Arg Ser Ile Asp Phe Glu Asp Ile Thr Ser Met Asp Thr Arg Ser Phe Ser Ser Asp Tyr Thr His Leu Pro Glu Cys Gln Asn Pro Trp Asp Ser Glu Pro Pro Met Tyr His Thr Ile Glu Arg Ser Lys Ser Ser Arg Tyr Leu Ala Thr Thr Pro Phe Leu Leu Glu Glu Ala Pro Ile Val Lys Ser His Ser Phe Met Phe Ser Pro Ser Arg Ser Tyr Tyr Ala Asn Phe Gly Val Pro Val Lys Thr Ala Glu Tyr Thr Ser Ile Thr Asp Cys Ile Asp Thr Arg Cys Val Asn Ala Pro Gln Ala Ile Ala Asp Arg Ala Ala Phe Pro Gly Gly Leu Gly Asp Lys Val Glu Asp Leu Thr Cys Cys His Pro Glu Arg Glu Ala Glu Leu Ser His Pro Ser Ser Asp Ser Glu Glu Asn Glu Ala Lys Gly Arg Arg Ala Thr Ile Ala Ile Ser Ser Gln Glu Gly Asp Asn Ser Glu Arg Thr Leu Ser Asn Asn Ile Thr Val Pro Lys Ile Glu Arg Ala Asn Ser Tyr Ser Ala Glu Glu Pro Ser Ala Pro Tyr Ala His Thr Arg Lys Ser Phe Ser Ile Ser Asp Lys Leu Asp Arg Gln Arg Asn Thr Ala Ser Leu Arg Asn Pro Phe Gln Arg Ser Lys Ser Ser Lys Pro Glu Gly Arg Gly Asp Ser Leu Ser Met Arg Lys Leu Ser Arg Thr Ser Ala Phe Gln Ser Phe Glu Ser Lys His Thr <210> 49 <211> 1101 <212> DNA
<213> homo sapiens <400>

atgggcggggcttatcgctgcaactacacgcgcaagcgcttccggaccctctaccacaac60 ctcttcggccccaagaggcccaaagccttgaaactgctgggaatggaggatgatattccc120 ttgaggcgaggaagaaagacaaccaagaaacgtgaagaagaggtggacattgacttggat180 gatcctgagatcaaccacttccccttccctttccatgagctcatggtgtgggctgttctc240 atgaagcggcagaagatggccctgttcttctggcagcacggtgaggaggccatggccaag300 gccctggtggcctgcaagctctgcaaagccatggctcatgaggcctctgagaacgacatg360 gttgacgacatttcccaggagctgaatcacaattccagagactttggccagctggctgtg420 gagctcctggaccagtcctacaagcaggacgaacagctggccatgaaactgctgacgtat480 gagctgaagaactggagcaacgccacgtgcctgcagcttgccgtggctgccaaacaccgc540 gacttcatcgcgcacacgtgcagccagatgctgctcaccgacatgtggatgggccggctc600 cgcatgcgcaagaactcaggcctcaaggtaattctgggaattctacttcctccttcaatt660 ctcagcttggagttcaagaacaaagacgacatgccctatatgtctcaggcccaggaaatc720 cacctccaagagaaggaggcagaagaaccagagaagcccacaaaggaaaaagaggaagag780 gacatggagctcacagcaatgttgggacgaaacaacggggagtcctccaggaagaaggat840 gaagaggaagttcagagcaagcaccggttaatccccctcggcagaaaaatctatgaattc900 tacaatgcacccatcgtgaagttctggttctacacactggcgtatatcggatacctgatg960 ctcttcaactatatcgtgttagtgaagatggaacgctggccgtccacccaggaatggatc1020 gtaatctcctatattttcacccttgttccagctggttgtctgcacttcggtcttcccatt1080 catggtgccttttcttcttga 1101 <210> 50 <211> 366 <212> PRT
<213> homo sapiens <400> 50 Met Gly Gly Ala Tyr Arg Cys Asn Tyr Thr Arg Lys Arg Phe Arg Thr Leu Tyr His Asn Leu Phe Gly Pro Lys Arg Pro Lys Ala Leu Lys Leu Leu Gly Met Glu Asp Asp Ile Pro Leu Arg Arg Gly Arg Lys Thr Thr Lys Lys Arg Glu Glu Glu Val Asp Ile Asp Leu Asp Asp Pro Glu Ile Asn His Phe Pro Phe Pro Phe His Glu Leu Met Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala Leu Phe Phe Trp Gln His Gly Glu Glu Ala Met Ala Lys Ala Leu Val Ala Cys Lys Leu Cys Lys Ala Met Ala His Glu Ala Ser Glu Asn Asp Met Val Asp Asp Ile Ser Gln Glu Leu Asn His Asn Ser Arg Asp Phe Gly Gln Leu Ala Val Glu Leu Leu Asp Gln Ser Tyr Lys Gln Asp Glu Gln Leu Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ala Thr Cys Leu Gln Leu Ala Val Ala Ala Lys His Arg Asp Phe Ile Ala His Thr Cys Ser Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg Leu Arg Met Arg Lys Asn Ser Gly Leu Lys Val Ile Leu Gly Ile Leu Leu Pro Pro Ser Ile Leu Ser Leu Glu Phe Lys Asn Lys Asp Asp Met Pro Tyr Met Ser Gln Ala Gln Glu Ile His Leu Gln Glu Lys Glu Ala Glu Glu Pro Glu Lys Pro Thr Lys Glu Lys Glu Glu Asp Met Glu Thr Ala Leu Gly Asn Asn Glu Leu Met Arg Gly Glu Ser Arg Lys Lys Glu Glu Val Gln Lys His Ser Asp Glu Ser Arg Leu Pro Leu Gly Arg Ile Tyr Phe Tyr Ala Pro Ile Lys Glu Asn Ile Val Phe Trp Phe Tyr Leu Ala Ile Gly Leu Met Lys Thr Tyr Tyr Leu Phe Tyr Ile Val Leu Lys Met Arg Trp Ser Thr Asn Val Glu Pro Gln Glu Ile Val Ile Ser Ile Phe Leu Val Ala Gly Trp Tyr Thr Pro Cys Leu Phe Gly Leu Pro His Gly Phe Ser His Ile Ala Ser <210>

<211>

<212>
DNA

<213> Sapiens homo <400>

atgggcggggcttatcgctg caactacacgcgcaagcgcttccggaccctctaccacaac60 ctcttcggccccaagaggcc caaagccttgaaactgctgggaatggaggatgatattccc120 ttgaggcgaggaagaaagac aaccaagaaacgtgaagaagaggtggacattgacttggat180 gatcctgagatcaaccactt ccccttccctttccatgagctcatggtgtgggctgttctc240 atgaagcggcagaagatggc cctgttcttctggcagcacggtgaggaggccatggccaag300 gccctggtggcctgcaagct ctgcaaagccatggctcatgaggcctctgagaacgacatg360 gttgacgacatttcccagga gctgaatcacaattccagagactttggccagctggctgtg420 gagctcctggaccagtccta caagcaggacgaacagctggccatgaaactgctgacgtat480 gagctgaagaactggagcaa cgccacgtgcctgcagcttgccgtggctgccaaacaccgc540 gacttcatcgcgcacacgtg cagccagatgctgctcaccgacatgtggatgggccggctc600 cgcatgcgcaagaactcagg cctcaaggtaattctgggaattctacttcctccttcaatt660 ctcagcttggagttcaagaa caaagacgacatgccctatatgtctcaggcccaggaaatc720 cacctccaagagaaggaggc agaagaaccagagaagcccacaaaggaaaaagaggaagag780 gacatggagctcacagcaat gttgggacgaaacaacggggagtcctccaggaagaaggat840 gaagaggaagttcagagcaa gcaccggttaatccccctcggcagaaaaatctatgaattc900 tacaatgcacccatcgtgaa gttctggttctacacactggcgtatatcggatacctgatg960 ctcttcaactatatcgtgtt agtgaagatggaacgctggccgtccacccaggaatggatc1020 gtaatctcctatattttcac cctgggaatagaaaagatgagagaggtaacggcttttata1080 aaagaaaacgtaagagaaag acagtggttaagttctatctgtggatggaggggacaggaa1140 gatgcctgggatgcaaatta a 1161 <210>

<211>

<212>
PRT

<213> Sapiens homo <400>

Met Gly Tyr Thr Lys Arg Arg Thr Gly Ala Arg Phe Tyr Arg Cys Asn Leu Tyr Lys Arg Lys Ala Lys Leu His Asn Pro Leu Leu Phe Gly Pro Leu Gly Leu Arg Gly Arg Thr Thr Met Glu Arg Lys Asp Asp Ile Pro Lys Lys Ile Asp Asp Asp Glu Ile Arg Glu Leu Pro Glu Glu Val Asp Asn His Glu Leu Val Trp Val Leu Phe Pro Met Ala Phe Pro Phe His Met Lys Phe Phe Gln His Glu Glu Arg Gln Trp Gly Lys Met Ala Leu Ala Met Cys Lys Cys Lys Met Ala Ala Lys Leu Ala Ala Leu Val Ala His Glu Ala Ser Glu Asn Asp Met Val Asp Asp Ile Ser Gln Glu Leu Asn His Asn Ser Arg Asp Phe Gly Gln Leu Ala Val Glu Leu Leu Asp Gln Ser Tyr Lys Gln Asp Glu Gln Leu Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ala Thr Cys Leu Gln Leu Ala Val Ala Ala Lys His Arg Asp Phe Ile Ala His Thr Cys Ser Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg Leu Arg Met Arg Lys Asn Ser Gly Leu Lys Val Ile Leu Gly Ile Leu Leu Pro Pro Ser Ile Leu Ser Leu Glu Phe Lys Asn Lys Asp Asp Met Pro Tyr Met Ser Gln Ala Gln Glu Ile His Leu Gln Glu Lys Glu Ala Glu Glu Pro Glu Lys Pro Thr Lys Glu Lys Glu Glu Glu Asp Met Glu Leu Thr Ala Met Leu Gly Arg Asn Asn Gly Glu Ser Ser Arg Lys Lys Asp Glu Glu Glu Val Gln Ser Lys His Arg Leu Ile Pro Leu Gly Arg Lys Ile Tyr Glu Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Leu Ala Tyr Ile Gly Tyr Leu Met Leu Phe Asn Tyr Ile Val Leu Val Lys Met Glu Arg Trp Pro Ser Thr Gln Glu Trp Ile Val Ile Ser Tyr Ile Phe Thr Leu Gly Ile Glu Lys Met Arg Glu Val Thr Ala Phe Ile Lys Glu Asn Val Arg Glu Arg Gln Trp Leu Ser Ser Ile Cys Gly Trp Arg Gly Gln Glu Asp Ala Trp Asp Ala Asn <210> 53 <211> 1536 <212> DNA
<213> homo sapiens <400> 53 atgggcggggcttatcgctgcaactacacgcgcaagcgcttccggaccctctaccacaac60 ctcttcggccccaagaggcccaaagccttgaaactgctgggaatggaggatgatattccc120 ttgaggcgaggaagaaagacaaccaagaaacgtgaagaagaggtggacattgacttggat180 gatcctgagatcaaccacttccccttccctttccatgagctcatggtgtgggctgttctc240 atgaagcggcagaagatggccctgttcttctggcagcacggtgaggaggccatggccaag300 gccctggtggcctgcaagctctgcaaagccatggctcatgaggcctctgagaacgacatg360 gttgacgacatttcccaggagctgaatcacaattccagagactttggccagctggctgtg420 gagctcctggaccagtcctacaagcaggacgaacagctggccatgaaactgctgacgtat480 gagctgaagaactggagcaacgccacgtgcctgcagcttgccgtggctgccaaacaccgc540 gacttcatcgcgcacacgtgcagccagatgctgctcaccgacatgtggatgggccggctc600 cgcatgcgcaagaactcaggcctcaaggtaattctgggaattctacttcctccttcaatt660 ctcagcttggagttcaagaacaaagacgacatgccctatatgtctcaggcccaggaaatc720 cacctccaagagaaggaggcagaagaaccagagaagcccacaaaggaaaaagaggaagag780 gacatggagctcacagcaatgttgggacgaaacaacggggagtcctccaggaagaaggat840 gaagaggaagttcagagcaagcaccggttaatccccctcggcagaaaaatctatgaattc900 tacaatgcacccatcgtgaagttctggttctacacactggcgtatatcggatacctgatg960 ctcttcaactatatcgtgttagtgaagatggaacgctggccgtccacccaggaatggatc1020 gtaatctcctatattttcaccctgggaatagaaaagatgagagagattctgatgtcagag1080 ccagggaagttgctacagaaagtgaaggtatggctgcaggagtactggaatgtcacggac1140 ctcatcgccatccttctgttttctgtcggaatgatccttcgtctccaagaccagcccttc1200 aggagtgacgggagggtcatctactgcgtgaacatcatttactggtatatccgtctccta1260 gacatcttcggcgtgaacaagtatttgggcccgtatgtaatgatgattggaaaaatgatg1320 atagacatgatgtactttgtcatcattatgctggtggttctgatgagctttggggtcgcc1380 aggcaagccatcctttttcccaatgaggagccatcatggaaactggccaagaacatcttc1440 tacatgccctattggatgatttatggggaagtgtttgcggaccagatagaccgtaagcaa1500 gtttatgattctcatacaccaaagtcaggtatttaa 1536 <210> 54 <211> 511 <212> PRT
<213> homo Sapiens <400> 54 Met Gly Gly Ala Tyr Arg Cys Asn Tyr Thr Arg Lys Arg Phe Arg Thr Leu Tyr His Asn Leu Phe Gly Pro Lys Arg Pro Lys Ala Leu Lys Leu Leu Gly Met Glu Asp Asp Ile Pro Leu Arg Arg Gly Arg Lys Thr Thr Lys Lys Arg Glu Glu Glu Val Asp Ile Asp Leu Asp Asp Pro Glu Ile Asn His Phe Pro Phe Pro Phe His Glu Leu Met Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala Leu Phe Phe Trp Gln His Gly Glu Glu Ala Met Ala Lys Ala Leu Val Ala Cys Lys Leu Cys Lys Ala Met Ala His Glu Ala Ser Glu Asn Asp Met Val Asp Asp Ile Ser Gln Glu Leu Asn His Asn Ser Arg Asp Phe Gly Gln Leu Ala Val Glu Leu Leu Asp Gln Ser Tyr Lys Gln Asp Glu Gln Leu Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ala Thr Cys Leu Gln Leu Ala Val Ala Ala Lys His Arg Asp Phe Ile Ala His Thr Cys Ser Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg Leu Arg Met Arg Lys Asn Ser Gly Leu Lys Val Ile Leu Gly Ile Leu Leu Pro Pro Ser Ile Leu Ser Leu Glu Phe Lys Asn Lys Asp Asp Met Pro Tyr Met Ser Gln Ala Gln Glu Ile His Leu Gln Glu Lys Glu Ala Glu Glu Pro Glu Lys Pro Thr Lys Glu Lys Glu Glu Glu Asp Met Glu Leu Thr Ala Met Leu Gly Arg Asn Asn Gly Glu Ser Ser Arg Lys Lys Asp Glu Glu Glu Val Gln Ser Lys His Arg Leu Ile Pro Leu Gly Arg Lys Ile Tyr Glu Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Leu Ala Tyr Ile Gly Tyr Leu Met Leu Phe Asn Tyr Ile Val Leu Val Lys Met Glu Arg Trp Pro Ser Thr Gln Glu Trp Ile Val Ile Ser Tyr Ile Phe Thr Leu Gly Ile Glu Lys Met Arg Glu Ile Leu Met Ser Glu Pro Gly Lys Leu Leu Gln Lys Val Lys Val Trp Leu Gln Glu Tyr Trp Asn Val Thr Asp Leu Ile Ala Ile Leu Leu Phe Ser Val Gly Met Ile Leu Arg Leu Gln Asp Gln Pro Phe Arg Ser Asp Gly Arg Val Ile Tyr Cys Val Asn Ile Ile Tyr Trp Tyr Ile Arg Leu Leu Asp Ile Phe Gly Val Asn Lys Tyr Leu Gly Pro Tyr Val Met Met Ile Gly Lys Met Met Ile Asp Met Met Tyr Phe Val Ile Ile Met Leu Val Val Leu Met Ser Phe Gly Val Ala Arg Gln Ala Ile Leu Phe Pro Asn Glu Glu Pro Ser Trp Lys Leu Ala Lys Asn Ile Phe Tyr Met Pro Tyr Trp Met Ile Tyr Gly Glu Val Phe Ala Asp Gln Ile Asp Arg Lys Gln Val Tyr Asp Ser His Thr Pro Lys Ser Gly Ile <210> 55 <211> 2094 <212> DNA
<213> homo Sapiens <400>

atgggcggggcttatcgctgcaactacacgcgcaagcgcttccggaccctctaccacaac60 ctcttcggccccaagaggcccaaagccttgaaactgctgggaatggaggatgatattccc120 ttgaggcgaggaagaaagacaaccaagaaacgtgaagaagaggtggacattgacttggat180 gatcctgagatcaaccacttccccttccctttccatgagctcatggtgtgggctgttctc240 atgaagcggcagaagatggccctgttcttctggcagcacggtgaggaggccatggccaag300 gccctggtggcctgcaagctctgcaaagccatggctcatgaggcctctgagaacgacatg360 gttgacgacatttcccaggagctgaatcacaattccagagactttggccagctggctgtg420 gagctcctggaccagtcctacaagcaggacgaacagctggccatgaaactgctgacgtat480 gagctgaagaactggagcaacgccacgtgcctgcagcttgccgtggctgccaaacaccgc540 gacttcatcgcgcacacgtgcagccagatgctgctcaccgacatgtggatgggccggctc600 cgcatgcgcaagaactcaggcctcaaggtaattctgggaattctacttcctccttcaatt660 ctcagcttggagttcaagaacaaagacgacatgccctatatgtctcaggcccaggaaatc720 cacctccaagagaaggaggcagaagaaccagagaagcccacaaaggaaaaagaggaagag780 gacatggagctcacagcaatgttgggacgaaacaacggggagtcctccaggaagaaggat840 gaagaggaagttcagagcaagcaccggttaatccccctcggcagaaaaatctatgaattc900 tacaatgcacccatcgtgaagttctggttctacacactggcgtatatcggatacctgatg960 ctcttcaactatatcgtgttagtgaagatggaacgctggccgtccacccaggaatggatc1020 gtaatctcctatattttcaccctgggaatagaaaagatgagagagattctgatgtcagag1080 ccagggaagttgctacagaaagtgaaggtatggctgcaggagtactggaatgtcacggac1140 ctcatcgccatccttctgttttctgtcggaatgatccttcgtctccaagaccagcccttc1200 aggagtgacgggagggtcatctactgcgtgaacatcatttactggtatatccgtctccta1260 gacatcttcggcgtgaacaagtatttgggcccgtatgtaatgatgattggaaaaatgatg1320 atagacatgatgtactttgtcatcattatgctggtggttctgatgagctttggggtcgcc1380 aggcaagccatcctttttcccaatgaggagccatcatggaaactggccaagaacatcttc1440 tacatgccctattggatgatttatggggaagtgtttgcggaccagatagaccctccctgt1500 ggacagaatgagacccgagaggatggtaaaataatccagctgcctccctgcaagacagga1560 gcttggatcgtgccggccatcatggcctgctacctcttagtggcaaacatcttgctggtc1620 aacctcctcattgctgtctttaacaatacattttttgaagtaaaatcgatatccaaccaa1680 gtctggaagtttcagaggtatcagctcatcatgactttccatgaaaggccagttctgccc1740 ccaccactgatcatcttcagccacatgaccatgatattccagcacctgtgctgccgatgg1800 aggaaacacgagagcgacccggatgaaagggactacggcctgaaactcttcataaccgat1860 gatgagctcaagaaagtacatgactttgaagagcaatgcatagaagaatacttcagagaa1920 aaggatgatcggttcaactcatctaatgatgagaggatacgggtgacttcagaaaggtgt1980 gttctgtggacacctgcctcctgcagatgtgttgtgccaaggcatgctttatccatcgaa2040 tttattcacacggtcacaaaacagagatcttttgtgtttgtttttattgtctga 2094 <210> 56 <211> 697 <212> PRT
<213> homo sapiens <400> 56 Met Gly Gly Ala Tyr Arg Cys Asn Tyr Thr Arg Lys Arg Phe Arg Thr Leu Tyr His Asn Leu Phe Gly Pro Lys Arg Pro Lys Ala Leu Lys Leu Leu Gly Met Glu Asp Asp Ile Pro Leu Arg Arg Gly Arg Lys Thr Thr Lys Lys Arg Glu Glu Glu Val Asp Ile Asp Leu Asp Asp Pro Glu Ile Asn His Phe Pro Phe Pro Phe His Glu Leu Met Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala Leu Phe Phe Trp Gln His Gly Glu Glu Ala Met Ala Lys Ala Leu Val Ala Cys Lys Leu Cys Lys Ala Met Ala His Glu Ala Ser Glu Asn Asp Met Val Asp Asp Ile Ser Gln Glu Leu Asn His Asn Ser Arg Asp Phe Gly Gln Leu Ala Val Glu Leu Leu Asp Gln Ser Tyr Lys Gln Asp Glu Gln Leu Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ala Thr Cys Leu Gln Leu Ala Val Ala Ala Lys His Arg Asp Phe Ile Ala His Thr Cys Ser Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg Leu Arg Met Arg Lys Asn Ser Gly Leu Lys Val Ile Leu Gly Ile Leu Leu Pro Pro Ser Ile Leu Ser Leu Glu Phe Lys Asn Lys Asp Asp Met Pro Tyr Met Ser Gln Ala Gln Glu Ile His Leu Gln Glu Lys Glu Ala Glu Glu Pro Glu Lys Pro Thr Lys Glu Lys Glu Glu Glu Asp Met Glu Leu Thr Ala Met Leu Gly Arg Asn Asn Gly Glu Ser Ser Arg Lys Lys Asp Glu Glu Glu Val Gln Ser Lys His Arg Leu Ile Pro Leu Gly Arg Lys Ile Tyr Glu Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Leu Ala Tyr Ile Gly Tyr Leu Met Leu Phe Asn Tyr Ile Val Leu Val Lys Met Glu Arg Trp Pro Ser Thr Gln Glu Trp Ile Val Ile Ser Tyr Ile Phe Thr Leu Gly Ile Glu Lys Met Arg Glu Ile Leu Met Ser Glu Pro Gly Lys Leu Leu Gln Lys Val Lys Val Trp Leu Gln Glu Tyr Trp Asn Val Thr Asp Leu Ile Ala Ile Leu Leu Phe Ser Val Gly Met Ile Leu Arg Leu Gln Asp Gln Pro Phe Arg Ser Asp Gly Arg Val Ile Tyr Cys Val Asn Ile Ile Tyr Trp Tyr Ile Arg Leu Leu Asp Ile Phe Gly Val Asn Lys Tyr Leu Gly Pro Tyr Val Met Met Ile Gly Lys Met Met Ile Asp Met Met Tyr Phe Val Ile Ile Met Leu Val Val Leu Met Ser Phe Gly Val Ala Arg Gln Ala Ile Leu Phe Pro Asn Glu Glu Pro Ser Trp Lys Leu Ala Lys Asn Ile Phe Tyr Met Pro Tyr Trp Met Ile Tyr Gly Glu Val Phe Ala Asp Gln Ile Asp Pro Pro Cys Gly Gln Asn Glu Thr Arg Glu Asp Gly Lys Ile Ile Gln Leu Pro Pro Cys Lys Thr Gly Ala Trp Ile Val Pro Ala Ile Met Ala Cys Tyr Leu Leu Val Ala Asn Ile Leu Leu Val Asn Leu Leu Ile Ala Val Phe Asn Asn Thr Phe Phe Glu Val Lys Ser Ile Ser Asn Gln Val Trp Lys Phe Gln Arg Tyr Gln Leu Ile Met Thr Phe His Glu Arg Pro Val Leu Pro Pro Pro Leu Ile Ile Phe Ser His Met Thr Met Ile Phe Gln His Leu Cys Cys Arg Trp Arg Lys His Glu Ser Asp Pro Asp Glu Arg Asp Tyr Gly Leu Lys Leu Phe Ile Thr Asp Asp Glu Leu Lys Lys Val His Asp Phe Glu Glu Gln Cys Ile Glu Glu Tyr Phe Arg Glu Lys Asp Asp Arg Phe Asn Ser Ser Asn Asp Glu Arg Ile Arg Val Thr Ser Glu Arg Cys Val Leu Trp Thr Pro Ala Ser Cys Arg Cys Val Val Pro Arg His Ala Leu Ser Ile Glu Phe Ile His Thr Val Thr Lys Gln Arg Ser Phe Val Phe Val Phe Ile Val <210> 57 <211> 2283 <212> DNA
<213> homo Sapiens <400>

atgggcggggcttatcgctgcaactacacgcgcaagcgcttccggaccctctaccacaac 60 ctcttcggccccaagaggcccaaagccttgaaactgctgggaatggaggatgatattccc 120 ttgaggcgaggaagaaagacaaccaagaaacgtgaagaagaggtggacattgacttggat 180 gatcctgagatcaaccacttccccttccctttccatgagctcatggtgtgggctgttctc 240 atgaagcggcagaagatggccctgttcttctggcagcacggtgaggaggccatggccaag 300 gccctggtggcctgcaagctctgcaaagccatggctcatgaggcctctgagaacgacatg 360 gttgacgacatttcccaggagctgaatcacaattccagagactttggccagctggctgtg 420 gagctcctggaccagtcctacaagcaggacgaacagctggccatgaaactgctgacgtat 480 gagctgaagaactggagcaacgccacgtgcctgcagcttgccgtggctgccaaacaccgc 540 gacttcatcgcgcacacgtgcagccagatgctgctcaccgacatgtggatgggccggctc 600 cgcatgcgcaagaactcaggcctcaaggtaattctgggaattctacttcctccttcaatt 660 ctcagcttggagttcaagaacaaagacgacatgccctatatgtctcaggcccaggaaatc 720 cacctccaagagaaggaggcagaagaaccagagaagcccacaaaggaaaaagaggaagag 780 gacatggagctcacagcaatgttgggacgaaacaacggggagtcctccaggaagaaggat 840 gaagaggaagttcagagcaagcaccggttaatccccctcggcagaaaaatctatgaattc 900 tacaatgcacccatcgtgaagttctggttctacacactggcgtatatcggatacctgatg 960 ctcttcaactatatcgtgttagtgaagatggaacgctggccgtccacccaggaatggatc 1020 gtaatctcctatattttcaccctgggaatagaaaagatgagagagattctgatgtcagag 1080 ccagggaagttgctacagaaagtgaaggtatggctgcaggagtactggaatgtcacggac 1140 ctcatcgccatccttctgttttctgtcggaatgatccttcgtctccaagaccagcccttc 1200 aggagtgacgggagggtcatctactgcgtgaacatcatttactggtatatccgtctccta 1260 gacatcttcggcgtgaacaagtatttgggcccgtatgtaatgatgattggaaaaatgatg 1320 atagacatgatgtactttgtcatcattatgctggtggttctgatgagctttggggtcgcc 1380 aggcaagccatcctttttcccaatgaggagccatcatggaaactggccaagaacatcttc 1440 tacatgccctattggatgatttatggggaagtgtttgcggaccagatagaccctccctgt 1500 ggacagaatgagacccgagaggatggtaaaataatccagctgcctccctgcaagacagga 1560 gcttggatcgtgccggccatcatggcctgctacctcttagtggcaaacatcttgctggtc 1620 aacctcctcattgctgtctttaacaatacattttttgaagtaaaatcgatatccaaccaa 1680 gtctggaagtttcagaggtatcagctcatcatgactttccatgaaaggccagttctgccc 1740 ccaccactgatcatcttcagccacatgaccatgatattccagcacctgtgctgccgatgg 1800 aggaaacacgagagcgacccggatgaaagggactacggcctgaaactcttcataaccgat 1860 gatgagctcaagaaagtacatgactttgaagagcaatgcatagaagaatacttcagagaa1920 aaggatgatcggttcaactcatctaatgatgagaggatacgggtgacttcagaaagggtg1980 gagaacatgtctatgcggctggaggaagtcaacgagagagagcactccatgaaggcttca2040 ctccagaccgtggacatccggctggcgcagctggaagaccttatcgggcgcatggccacg2100 gccctggagcgcctgacaggtctggagcgggccgagtccaacaaaatccgctcgaggacc2160 tcgtcagactgcacggacgccgcctacattgtccgtcagagcagcttcaacagccaggaa2220 gggaacaccttcaagctccaagagagtatagaccctgcagagcatcctctttattcagta2280 taa <210> 58 <211> 760 <212> PRT
<213> homo sapiens <400> 58 Met Gly Gly Ala Tyr Arg Cys Asn Tyr Thr Arg Lys Arg Phe Arg Thr Leu Tyr His Asn Leu Phe Gly Pro Lys Arg Pro Lys Ala Leu Lys Leu Leu Gly Met Glu Asp Asp Ile Pro Leu Arg Arg Gly Arg Lys Thr Thr Lys Lys Arg Glu Glu Glu Val Asp Ile Asp Leu Asp Asp Pro Glu Ile Asn His Phe Pro Phe Pro Phe His Glu Leu Met Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala Leu Phe Phe Trp Gln His Gly Glu Glu Ala Met Ala Lys Ala Leu Val Ala Cys Lys Leu Cys Lys Ala Met Ala His Glu Ala Ser Glu Asn Asp Met Val Asp Asp Ile Ser Gln Glu Leu Asn His Asn Ser Arg Asp Phe Gly Gln Leu Ala Val Glu Leu Leu Asp Gln Ser Tyr Lys Gln Asp Glu Gln Leu Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ala Thr Cys Leu Gln Leu Ala Val Ala Ala Lys His Arg Asp Phe Ile Ala His Thr Cys Ser Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg Leu Arg Met Arg Lys Asn Ser Gly Leu Lys Val Ile Leu Gly Ile Leu Leu Pro Pro Ser Ile Leu Ser Leu Glu Phe Lys Asn Lys Asp Asp Met Pro Tyr Met Ser Gln Ala Gln Glu Ile His Leu Gln Glu Lys Glu Ala Glu Glu Pro Glu Lys Pro Thr Lys Glu Lys Glu Glu Glu Asp Met Glu Leu Thr Ala Met Leu Gly Arg Asn Asn Gly Glu Ser Ser Arg Lys Lys Asp Glu Glu Glu Val Gln Ser Lys His Arg Leu Ile Pro Leu Gly Arg Lys Ile Tyr Glu Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Leu Ala Tyr Ile Gly Tyr Leu Met Leu Phe Asn Tyr Ile Val Leu Val Lys Met Glu Arg Trp Pro Ser Thr Gln Glu Trp Ile Val Ile Ser Tyr Ile Phe Thr Leu Gly Ile Glu Lys Met Arg Glu Ile Leu Met Ser Glu Pro Gly Lys Leu Leu Gln Lys Val Lys Val Trp Leu Gln Glu Tyr Trp Asn Val Thr Asp Leu Ile Ala Ile Leu Leu Phe Ser Val Gly Met Ile Leu Arg Leu Gln Asp Gln Pro Phe Arg Ser Asp Gly Arg Val Ile Tyr Cys Val Asn Ile Ile Tyr Trp Tyr Ile Arg Leu Leu Asp Ile Phe Gly Val Asn Lys Tyr Leu Gly Pro Tyr Val Met Met Ile Gly Lys Met Met Ile Asp Met Met Tyr Phe Val Ile Ile Met Leu Val Val Leu Met Ser Phe Gly Val Ala Arg Gln Ala Ile Leu Phe Pro Asn Glu Glu Pro Ser Trp Lys Leu Ala Lys Asn Ile Phe 465 ~ 470 475 480 Tyr Met Pro Tyr Trp Met Ile Tyr Gly Glu Val Phe Ala Asp Gln Ile Asp Pro Pro Cys Gly Gln Asn Glu Thr Arg Glu Asp Gly Lys Ile Ile Gln Leu Pro Pro Cys Lys Thr Gly Ala Trp Ile Val Pro Ala Ile Met Ala Cys Tyr Leu Leu Val Ala Asn Ile Leu Leu Val Asn Leu Leu Ile Ala Val Phe Asn Asn Thr Phe Phe Glu Val Lys Ser Ile Ser Asn Gln Val Trp Lys Phe Gln Arg Tyr Gln Leu Ile Met Thr Phe His Glu Arg Pro Val Leu Pro Pro Pro Leu Ile Ile Phe Ser His Met Thr Met Ile Phe Gln His Leu Cys Cys Arg Trp Arg Lys His Glu Ser Asp Pro Asp Glu Arg Asp Tyr Gly Leu Lys Leu Phe Ile Thr Asp Asp Glu Leu Lys Lys Val His Asp Phe Glu Glu Gln Cys Ile Glu Glu Tyr Phe Arg Glu Lys Asp Asp Arg Phe Asn Ser Ser Asn Asp Glu Arg Ile Arg Val Thr Ser Glu Arg Val Glu Asn Met Ser Met Arg Leu Glu Glu Val Asn Glu Arg Glu His Ser Met Lys Ala Ser Leu Gln Thr Val Asp Ile Arg Leu Ala Gln Leu Glu Asp Leu Ile Gly Arg Met Ala Thr Ala Leu Glu Arg Leu Thr Gly Leu Glu Arg Ala Glu Ser Asn Lys Ile Arg Ser Arg Thr Ser Ser Asp Cys Thr Asp Ala Ala Tyr Ile Val Arg Gln Ser Ser Phe Asn Ser Gln Glu Gly Asn Thr Phe Lys Leu Gln Glu Ser Ile Asp Pro Ala Glu His Pro Leu Tyr Ser Val <210> 59 <211> 3429 <212> DNA
<213> homo Sapiens <400>

atgggcggggcttatcgctgcaactacacgcgcaagcgcttccggaccctctaccacaac 60 ctcttcggccccaagaggcccaaagccttgaaactgctgggaatggaggatgatattccc 120 ttgaggcgaggaagaaagacaaccaagaaacgtgaagaagaggtggacattgacttggat 180 gatcctgagatcaaccacttccccttccctttccatgagctcatggtgtgggctgttctc 240 atgaagcggcagaagatggccctgttcttctggcagcacggtgaggaggccatggccaag 300 gccctggtggcctgcaagctctgcaaagccatggctcatgaggcctctgagaacgacatg 360 gttgacgacatttcccaggagctgaatcacaattccagagactttggccagctggctgtg 420 gagctcctggaccagtcctacaagcaggacgaacagctggccatgaaactgctgacgtat 480 gagctgaagaactggagcaacgccacgtgcctgcagcttgccgtggctgccaaacaccgc 540 gacttcatcgcgcacacgtgcagccagatgctgctcaccgacatgtggatgggccggctc 600 cgcatgcgcaagaactcaggcctcaaggtaattctgggaattctacttcctccttcaatt 660 ctcagcttggagttcaagaacaaagacgacatgccctatatgtctcaggcccaggaaatc 720 cacctccaagagaaggaggcagaagaaccagagaagcccacaaaggaaaaagaggaagag 780 gacatggagctcacagcaatgttgggacgaaacaacggggagtcctccaggaagaaggat 840 gaagaggaagttcagagcaagcaccggttaatccccctcggcagaaaaatctatgaattc 900 tacaatgcacccatcgtgaagttctggttctacacactggcgtatatcggatacctgatg 960 ctcttcaactatatcgtgttagtgaagatggaacgctggccgtccacccaggaatggatc 1020 gtaatctcctatattttcaccctgggaatagaaaagatgagagagattctgatgtcagag 1080 ccagggaagttgctacagaaagtgaaggtatggctgcaggagtactggaatgtcacggac 1140 ctcatcgccatccttctgttttctgtcggaatgatccttcgtctccaagaccagcccttc 1200 aggagtgacgggagggtcatctactgcgtgaacatcatttactggtatatccgtctccta 1260 gacatcttcggcgtgaacaagtatttgggcccgtatgtaatgatgattggaaaaatgatg 1320 atagacatgatgtactttgtcatcattatgctggtggttctgatgagctttggggtcgcc 1380 aggcaagccatcctttttcccaatgaggagccatcatggaaactggccaagaacatcttc 1440 tacatgccctattggatgatttatggggaagtgtttgcggaccagatagaccctccctgt 1500 ggacagaatgagacccgagaggatggtaaaataatccagctgcctccctgcaagacagga 1560 gcttggatcgtgccggccatcatggcctgctacctcttagtggcaaacatcttgctggtc 1620 aacctcctcattgctgtctttaacaatacattttttgaagtaaaatcgatatccaaccaa 1680 gtctggaagtttcagaggtatcagctcatcatgactttccatgaaaggccagttctgccc 1740 ccaccactgatcatcttcagccacatgaccatgatattccagcacctgtgctgccgatgg 1800 aggaaacacgagagcgacccggatgaaagggactacggcctgaaactcttcataaccgat 1860 gatgagctcaagaaagtacatgactttgaagagcaatgcatagaagaatacttcagagaa 1920 aaggatgatcggttcaactcatctaatgatgagaggatacgggtgacttcagaaagggtg 1980 gagaacatgtctatgcggctggaggaagtcaacgagagagagcactccatgaaggcttca 2040 ctccagaccgtggacatccggctggcgcagctggaagaccttatcgggcgcatggccacg 2100 gccctggagcgcctgacaggtctggagcgggccgagtccaacaaaatccgctcgaggacc 2160 tcgtcagactgcacggacgccgcctacattgtccgtcagagcagcttcaacagccaggaa 2220 gggaacaccttcaagctccaagagagtatagaccctgcaggtgaggagaccatgtcccca 2280 acttctccaaccttaatgccccgtatgcgaagccattctttctattcggtcaatatgaaa 2340 gacaaaggtggtatagaaaagttggaaagtatttttaaagaaaggtccctgagcctacac 2400 cgggctactagttcccactctgtagcaaaagaacccaaagctcctgcagcccctgccaac 2460 accttggccattgttcctgattccagaagaccatcatcgtgtatagacatctatgtctct 2520 gctatggatgagctccactgtgatatagaccctctggacaattccgtgaacatccttggg 2580 ctaggcgagccaagcttttcaactccagtaccttccacagccccttcaagtagtgcctat 2640 gcaacacttgcacccacagacagacctccaagccggagcattgattttgaggacatcacc 2700 tccatggacactagatctttttcttcagactacacccacctcccagaatgccaaaacccc 2760 tgggactcagagcctccgatgtaccacaccattgagcgttccaaaagtagccgctaccta 2820 gccaccacaccctttcttctagaagaggctcccattgtgaaatctcatagctttatgttt 2880 tccccctcaaggagctattatgccaactttggggtgcctgtaaaaacagcagaatacaca 2940 agtattacagactgtattgacacaaggtgtgtcaatgcccctcaagcaattgcggacaga 3000 gctgccttccctggaggtcttggagacaaagtggaggacttaacttgctgccatccagag 3060 cgagaagcagaactgagtcaccccagctctgacagtgaggagaatgaggccaaaggccgc 3120 agagccaccattgcaatatcctcccaggagggtgataactcagagagaaccctgtccaac 3180 aacatcactgttcccaagatagagcgcgccaacagctactcggcagaggagccaagtgcg 3240 ccatatgcacacaccaggaagagcttctccatcagtgacaaactcgacaggcagcggaac 3300 acagcaagcctgcgaaatcccttccagagaagcaagtcctccaagccggagggccgaggg 3360 gacagcctgtccatgaggaaactgtccagaacatcggctttccaaagctttgaaagcaag 3420 cacacctaa 3429 <210> 60 <211> 1142 <212> PRT
<213> homo sapiens <400> 60 Met Gly Gly Ala Tyr Arg Cys Asn Tyr Thr Arg Lys Arg Phe Arg Thr Leu Tyr His Asn Leu Phe Gly Pro Lys Arg Pro Lys Ala Leu Lys Leu Leu Gly Met Glu Asp Asp Ile Pro Leu Arg Arg Gly Arg Lys Thr Thr Lys Lys Arg Glu Glu Glu Val Asp Ile Asp Leu Asp Asp Pro Glu Ile Asn His Phe Pro Phe Pro Phe His Glu Leu Met Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala Leu Phe Phe Trp Gln His Gly Glu Glu Ala Met Ala Lys Ala Leu Val Ala Cys Lys Leu Cys Lys Ala Met Ala His Glu Ala Ser Glu Asn Asp Met Val Asp Asp Ile Ser Gln Glu Leu Asn His Asn Ser Arg Asp Phe Gly Gln Leu Ala Val Glu Leu Leu Asp Gln Ser Tyr Lys Gln Asp Glu Gln Leu Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ala Thr Cys Leu Gln Leu Ala Val Ala Ala Lys His Arg Asp Phe Ile Ala His Thr Cys Ser Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg Leu Arg Met Arg Lys Asn Ser Gly Leu Lys Val Ile Leu Gly Ile Leu Leu Pro Pro Ser Ile Leu Ser Leu Glu Phe Lys Asn Lys Asp Asp Met Pro Tyr Met Ser Gln Ala Gln Glu Ile His Leu Gln Glu Lys Glu Ala Glu Glu Pro Glu Lys Pro Thr Lys Glu Lys Glu Glu Glu Asp Met Glu Leu Thr Ala Met Leu Gly Arg Asn Asn 26'0 265 270 Gly Glu Ser Ser Arg Lys Lys Asp Glu Glu Glu Val Gln Ser Lys His Arg Leu Ile Pro Leu Gly Arg Lys Ile Tyr Glu Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Leu Ala Tyr Ile Gly Tyr Leu Met Leu Phe Asn Tyr Ile Val Leu Val Lys Met Glu Arg Trp Pro Ser Thr Gln Glu Trp Ile Val Ile Ser Tyr Ile Phe Thr Leu Gly Ile Glu Lys Met Arg Glu Ile Leu Met Ser Glu Pro Gly Lys Leu Leu Gln Lys Val Lys Val Trp Leu Gln Glu Tyr Trp Asn Val Thr Asp Leu Ile Ala Ile Leu Leu Phe Ser Val Gly Met Ile Leu Arg Leu Gln Asp Gln Pro Phe Arg Ser Asp Gly Arg Val Ile Tyr Cys Val Asn Ile Ile Tyr Trp Tyr Ile Arg Leu Leu Asp Ile Phe Gly Val Asn Lys Tyr Leu Gly Pro Tyr Val Met Met Ile Gly Lys Met Met Ile Asp Met Met Tyr Phe Val Ile Ile Met Leu Val Val Leu Met Ser Phe Gly Val Ala Arg Gln Ala Ile Leu Phe Pro Asn Glu Glu Pro Ser Trp Lys Leu Ala Lys Asn Ile Phe Tyr Met Pro Tyr Trp Met Ile Tyr Gly Glu Val Phe Ala Asp Gln Ile Asp Pro Pro Cys Gly Gln Asn Glu Thr Arg Glu Asp Gly Lys Ile Ile Gln Leu Pro Pro Cys Lys Thr Gly Ala Trp Ile Val Pro Ala Ile Met Ala Cys Tyr Leu Leu Val Ala Asn Ile Leu Leu Val Asn Leu Leu Ile Ala Val Phe Asn Asn Thr Phe Phe Glu Val Lys Ser Ile Ser Asn Gln Val Trp Lys Phe Gln Arg Tyr Gln Leu Ile Met Thr Phe His Glu Arg Pro Val Leu Pro Pro Pro Leu Ile Ile Phe Ser His Met Thr Met Ile Phe Gln His Leu Cys Cys Arg Trp Arg Lys His Glu Ser Asp Pro Asp Glu Arg Asp Tyr Gly Leu Lys Leu Phe Ile Thr Asp Asp Glu Leu Lys Lys Val His Asp Phe Glu Glu Gln Cys Ile Glu Glu Tyr Phe Arg Glu Lys Asp Asp Arg Phe Asn Ser Ser Asn Asp Glu Arg Ile Arg Val Thr Ser Glu Arg Val Glu Asn Met Ser Met Arg Leu Glu Glu Val Asn Glu Arg Glu His Ser Met Lys Ala Ser Leu Gln Thr Val Asp Ile Arg Leu Ala Gln Leu Glu Asp Leu Ile Gly Arg Met Ala Thr Ala Leu Glu Arg Leu Thr Gly Leu Glu Arg Ala Glu Ser Asn Lys Ile Arg Ser Arg Thr Ser Ser Asp Cys Thr Asp Ala Ala Tyr Ile Val Arg Gln Ser Ser Phe Asn Ser Gln Glu Gly Asn Thr Phe Lys Leu Gln Glu Ser Ile Asp Pro Ala Gly Glu Glu Thr Met Ser Pro Thr Ser Pro Thr Leu Met Pro Arg Met Arg Ser His Ser Phe Tyr Ser Val Asn Met Lys Asp Lys Gly Gly Ile Glu Lys Leu Glu Ser Ile Phe Lys Glu Arg Ser Leu Ser Leu His Arg Ala Thr Ser Ser His Ser Val Ala Lys Glu Pro Lys Ala Pro Ala Ala Pro Ala Asn Thr Leu Ala Ile Val Pro Asp Ser Arg Arg Pro Ser Ser Cys Ile Asp Ile Tyr Val Ser Ala Met Asp Glu Leu His Cys Asp Ile Asp Pro Leu Asp Asn Ser Val Asn Ile Leu Gly Leu Gly Glu Pro Ser Phe Ser Thr Pro Val Pro Ser Thr Ala Pro Ser Ser Ser Ala Tyr Ala Thr Leu Ala Pro Thr Asp Arg Pro Pro Ser Arg Ser Ile Asp Phe Glu Asp Ile Thr Ser Met Asp Thr Arg Ser Phe Ser Ser Asp Tyr Thr His Leu Pro Glu Cys Gln Asn Pro Trp Asp Ser Glu Pro Pro Met Tyr His Thr Ile Glu Arg Ser Lys Ser Ser Arg Tyr Leu Ala Thr Thr Pro Phe Leu Leu Glu Glu Ala Pro Ile Val Lys Ser His Ser Phe Met Phe Ser Pro Ser Arg Ser Tyr Tyr Ala Asn Phe Gly Val Pro Val Lys Thr Ala Glu Tyr Thr Ser Ile Thr Asp Cys Ile Asp Thr Arg Cys Val Asn Ala Pro Gln Ala Ile Ala Asp Arg Ala Ala Phe Pro Gly Gly Leu Gly Asp Lys Val Glu Asp Leu Thr Cys Cys His Pro Glu Arg Glu Ala Glu Leu Ser His Pro Ser Ser Asp Ser Glu Glu Asn Glu Ala Lys Gly Arg Arg Ala Thr Ile Ala Ile Ser Ser Gln Glu Gly Asp Asn Ser Glu Arg Thr Leu Ser Asn Asn Ile Thr Val Pro Lys Ile Glu Arg Ala Asn Ser Tyr Ser Ala Glu Glu Pro Ser Ala Pro Tyr Ala His Thr Arg Lys Ser Phe Ser Ile Ser Asp Lys Leu Asp Arg Gln Arg Asn Thr Ala Ser Leu Arg Asn Pro Phe Gln Arg Ser Lys Ser Ser Lys Pro Glu Gly Arg Gly Asp Ser Leu Ser Met Arg Lys Leu Ser Arg Thr Ser Ala Phe Gln Ser Phe Glu Ser Lys His Thr <210> 61 <211> 1071 <212> DNA

<213> homo sapiens <400> 61 atgggcgggg cttatcgctg caactacacgcgcaagcgcttccggaccctctaccacaac60 ctcttcggcc ccaagaggga tgatattcccttgaggcgaggaagaaagacaaccaagaaa120 cgtgaagaag aggtggacat tgacttggatgatcctgagatcaaccacttccccttccct180 ttccatgagc tcatggtgtg ggctgttctcatgaagcggcagaagatggccctgttcttc240 tggcagcacg gtgaggaggc catggccaaggccctggtggcctgcaagctctgcaaagcc300 atggctcatg aggcctctga gaacgacatggttgacgacatttcccaggagctgaatcac360 aattccagag actttggcca gctggctgtggagctcctggaccagtcctacaagcaggac420 gaacagctgg ccatgaaact gctgacgtatgagctgaagaactggagcaacgccacgtgc480 ctgcagcttg ccgtggctgc caaacaccgcgacttcatcgcgcacacgtgcagccagatg540 ctgctcaccg acatgtggat gggccggctccgcatgcgcaagaactcaggcctcaaggta600 attctgggaa ttctacttcc tccttcaattctcagcttggagttcaagaacaaagacgac660 atgccctata tgtctcaggc ccaggaaatccacctccaagagaaggaggcagaagaacca720 gagaagccca caaaggaaaa agaggaagaggacatggagctcacagcaatgttgggacga780 aacaacgggg agtcctccag gaagaaggatgaagaggaagttcagagcaagcaccggtta840 atccccctcg gcagaaaaat ctatgaattctacaatgcacccatcgtgaagttctggttc900 tacacactgg cgtatatcgg atacctgatgctcttcaactatatcgtgttagtgaagatg960 gaacgctggc cgtccaccca ggaatggatcgtaatctcctatattttcacccttgttcca1020 gctggttgtc tgcacttcgg tcttcccattcatggtgccttttcttcttga 1071 <210> 62 <211> 356 <212> PRT

<213> homo sapiens <400> 62 Met Gly Gly Ala Tyr Arg Tyr Thr Lys Arg Arg Thr Cys Asn Arg Phe Leu Tyr His Asn Leu Phe Lys Arg Asp Ile Leu Arg Gly Pro Asp Pro Arg Gly Arg Lys Thr Thr Arg Glu Glu Val Ile Asp Lys Lys Glu Asp Leu Asp Asp Pro Glu Ile Phe Pro Pro Phe Glu Leu Asn His Phe His Met Val Trp Ala Val Leu Arg Gln Met Ala Phe Phe Met Lys Lys Leu Trp Gln His Gly Glu Glu Ala Lys Leu Val Cys Lys Ala Met Ala Ala Leu Cys Lys Ala Met Ala Ala Ser Asn Asp Val Asp His Glu Glu Met Asp Ile Ser Gln Glu Leu Asn Ser Asp Phe Asn His Arg Gly Gln Leu Ala Val Glu Leu Leu Asp Tyr Lys Asp Glu Leu Ala Gln Ser Gln Gln Met Lys Leu Leu Thr Tyr Lys Asn Ser Asn Thr Cys Glu Leu Trp Ala Leu Gln Leu Ala Val Ala Ala Lys His Arg Asp Phe Ile Ala His Thr Cys Ser Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg Leu Arg Met Arg Lys Asn Ser Gly Leu Lys Val Ile Leu Gly Ile Leu Leu Pro Pro Ser Ile Leu Ser Leu Glu Phe Lys Asn Lys Asp Asp Met Pro Tyr Met Ser Gln Ala Gln Glu Ile His Leu Gln Glu Lys Glu Ala Glu Glu Pro Glu Lys Pro Thr Lys Glu Lys Glu Glu Glu Asp Met Glu Leu Thr Ala Met Leu Gly Arg Asn Asn Gly Glu Ser Ser Arg Lys Lys Asp Glu Glu Glu Val Gln Ser Lys His Arg Leu Ile Pro Leu Gly Arg Lys Ile Tyr Glu Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Leu Ala Tyr Ile Gly Tyr Leu Met Leu Phe Asn Tyr Ile Val Leu Val Lys Met Glu Arg Trp Pro Ser Thr Gln Glu Trp Ile Val Ile Ser Tyr Ile Phe Thr Leu Val Pro Ala Gly Cys Leu His Phe Gly Leu Pro Ile His Gly Ala Phe Ser Ser <210>

<211>

<212>
DNA

<213> sapiens homo <400>

atgggcggggcttatcgctgcaactacacgcgcaagcgcttccggaccctctaccacaac 60 ctcttcggccccaagagggatgatattcccttgaggcgaggaagaaagacaaccaagaaa 120 cgtgaagaagaggtggacattgacttggatgatcctgagatcaaccacttccccttccct 180 ttccatgagctcatggtgtgggctgttctcatgaagcggcagaagatggccctgttcttc 240 tggcagcacggtgaggaggccatggccaaggccctggtggcctgcaagctctgcaaagcc 300 atggctcatgaggcctctgagaacgacatggttgacgacatttcccaggagctgaatcac 360 aattccagagactttggccagctggctgtggagctcctggaccagtcctacaagcaggac 420 gaacagctggccatgaaactgctgacgtatgagctgaagaactggagcaacgccacgtgc 480 ctgcagcttgccgtggctgccaaacaccgcgacttcatcgcgcacacgtgcagccagatg 540 ctgctcaccgacatgtggatgggccggctccgcatgcgcaagaactcaggcctcaaggta 600 attctgggaattctacttcctccttcaattctcagcttggagttcaagaacaaagacgac 660 atgccctatatgtctcaggcccaggaaatccacctccaagagaaggaggcagaagaacca 720 gagaagcccacaaaggaaaaagaggaagaggacatggagctcacagcaatgttgggacga 780 aacaacggggagtcctccaggaagaaggatgaagaggaagttcagagcaagcaccggtta 840 atccccctcggcagaaaaatctatgaattctacaatgcacccatcgtgaagttctggttc 900 tacacactggcgtatatcggatacctgatgctcttcaactatatcgtgttagtgaagatg 960 gaacgctggccgtccacccaggaatggatcgtaatctcctatattttcaccctgggaata 1020 gaaaagatgagagaggtaacggcttttataaaagaaaacgtaagagaaagacagtggtta 1080 agttctatctgtggatggaggggacaggaagatgcctgggatgcaaattaa 1131 <210>

<211>

<212>
PRT

<213> sapiens homo <400>

Met Gly Lys Arg Gly Phe Arg Ala Thr Tyr Arg Cys Asn Tyr Thr Arg Leu Tyr Asp Ile His Pro Leu Asn Arg Leu Phe Gly Pro Lys Arg Asp Arg Gly Arg Lys Thr Thr Lys Lys Arg Glu Glu Glu Val Asp Ile Asp Leu Asp Asp Pro Glu Ile Asn His Phe Pro Phe Pro Phe His Glu Leu Met Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala Leu Phe Phe Trp Gln His Gly Glu Glu Ala Met Ala Lys Ala Leu Val Ala Cys Lys Leu Cys Lys Ala Met Ala His Glu Ala Ser Glu Asn Asp Met Val Asp Asp Ile Ser Gln Glu Leu Asn His Asn Ser Arg Asp Phe Gly Gln Leu Ala Val Glu Leu Leu Asp Gln Ser Tyr Lys Gln Asp Glu Gln Leu Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ala Thr Cys Leu Gln Leu Ala Val Ala Ala Lys His Arg Asp Phe Ile Ala His Thr Cys Ser Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg Leu Arg Met Arg Lys Asn Ser Gly Leu Lys Val Ile Leu Gly Ile Leu Leu Pro Pro Ser Ile Leu Ser Leu Glu Phe Lys Asn Lys Asp Asp Met Pro Tyr Met Ser Gln Ala Gln Glu Ile His Leu Gln Glu Lys Glu Ala Glu Glu Pro Glu Lys Pro Thr Lys Glu Lys Glu Glu Glu Asp Met Glu Leu Thr Ala Met Leu Gly Arg Asn Asn Gly Glu Ser Ser Arg Lys Lys Asp Glu Glu Glu Val Gln Ser Lys His Arg Leu Ile Pro Leu Gly Arg Lys Ile Tyr Glu Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Leu Ala Tyr Ile Gly Tyr Leu Met Leu Phe Asn Tyr Ile Val Leu Val Lys Met Glu Arg Trp Pro Ser Thr Gln Glu Trp Ile Val Ile Ser Tyr Ile Phe Thr Leu Gly Ile Glu Lys Met Arg Glu Val Thr Ala Phe Ile Lys Glu Asn Val Arg Glu Arg Gln Trp Leu Ser Ser Ile Cys Gly Trp Arg Gly Gln Glu Asp Ala Trp Asp Ala Asn <210> 65 <211> 1506 <212> DNA
<213> homo sapiens <400> 65 atgggcggggcttatcgctgcaactacacgcgcaagcgcttccggaccctctaccacaac 60 ctcttcggccccaagagggatgatattcccttgaggcgaggaagaaagacaaccaagaaa 120 cgtgaagaagaggtggacattgacttggatgatcctgagatcaaccacttccccttccct 180 ttccatgagctcatggtgtgggctgttctcatgaagcggcagaagatggccctgttcttc 240 tggcagcacggtgaggaggccatggccaaggccctggtggcctgcaagctctgcaaagcc 300 atggctcatgaggcctctgagaacgacatggttgacgacatttcccaggagctgaatcac 360 aattccagagactttggccagctggctgtggagctcctggaccagtcctacaagcaggac 420 gaacagctggccatgaaactgctgacgtatgagctgaagaactggagcaacgccacgtgc 480 ctgcagcttgccgtggctgccaaacaccgcgacttcatcgcgcacacgtgcagccagatg 540 ctgctcaccgacatgtggatgggccggctccgcatgcgcaagaactcaggcctcaaggta 600 attctgggaattctacttcctccttcaattctcagcttggagttcaagaacaaagacgac 660 atgccctatatgtctcaggcccaggaaatccacctccaagagaaggaggcagaagaacca720 gagaagcccacaaaggaaaaagaggaagaggacatggagctcacagcaatgttgggacga780 aacaacggggagtcctccaggaagaaggatgaagaggaagttcagagcaagcaccggtta840 atccccctcggcagaaaaatctatgaattctacaatgcacccatcgtgaagttctggttc900 tacacactggcgtatatcggatacctgatgctcttcaactatatcgtgttagtgaagatg960 gaacgctggccgtccacccaggaatggatcgtaatctcctatattttcaccctgggaata1020 gaaaagatgagagagattctgatgtcagagccagggaagttgctacagaaagtgaaggta1080 tggctgcaggagtactggaatgtcacggacctcatcgccatccttctgttttctgtcgga1140 atgatccttcgtctccaagaccagcccttcaggagtgacgggagggtcatctactgcgtg1200 aacatcatttactggtatatccgtctcctagacatcttcggcgtgaacaagtatttgggc1260 ccgtatgtaatgatgattggaaaaatgatgatagacatgatgtactttgtcatcattatg1320 ctggtggttctgatgagctttggggtcgccaggcaagccatcctttttcccaatgaggag1380 ccatcatggaaactggccaagaacatcttctacatgccctattggatgatttatggggaa1440 gtgtttgcggaccagatagaccgtaagcaagtttatgattctcatacaccaaagtcaggt1500 atttaa 1506 <210> 66 <211> 501 <212> PRT
<213> homo sapiens <400> 66 Met Gly Gly Ala Tyr Arg Cys Asn Tyr Thr Arg Lys Arg Phe Arg_Thr Leu Tyr His Asn Leu Phe Gly Pro Lys Arg Asp Asp Ile Pro Leu Arg Arg Gly Arg Lys Thr Thr Lys Lys Arg Glu Glu Glu Val Asp Ile Asp Leu Asp Asp Pro Glu Ile Asn His Phe Pro Phe Pro Phe His Glu Leu Met Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala Leu Phe Phe Trp Gln His Gly Glu Glu Ala Met Ala Lys Ala Leu Val Ala Cys Lys Leu Cys Lys Ala Met Ala His Glu Ala Ser Glu Asn Asp Met Val Asp Asp Ile Ser Gln Glu Leu Asn His Asn Ser Arg Asp Phe Gly Gln Leu Ala Val Glu Leu Leu Asp Gln Ser Tyr Lys Gln Asp Glu Gln Leu Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ala Thr Cys Leu Gln Leu Ala Val Ala Ala Lys His Arg Asp Phe Ile Ala His Thr Cys Ser Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg Leu Arg Met Arg Lys Asn Ser Gly Leu Lys Val Ile Leu Gly Ile Leu Leu Pro Pro Ser Ile Leu Ser Leu Glu Phe Lys Asn Lys Asp Asp Met Pro Tyr Met Ser Gln Ala Gln Glu Ile His Leu Gln Glu Lys Glu Ala Glu Glu Pro Glu Lys Pro Thr Lys Glu Lys Glu Glu Glu Asp Met Glu Leu Thr Ala Met Leu Gly Arg Asn Asn Gly Glu Ser Ser Arg Lys Lys Asp Glu Glu Glu Val Gln Ser Lys His Arg Leu Ile Pro Leu Gly Arg Lys Ile Tyr Glu Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Leu Ala Tyr Ile Gly Tyr Leu Met Leu Phe Asn Tyr Ile Val Leu Val Lys Met Glu Arg Trp Pro Ser Thr Gln Glu Trp Ile Val Ile Ser Tyr Ile Phe Thr Leu Gly Ile Glu Lys Met Arg Glu Ile Leu Met Ser Glu Pro Gly Lys Leu Leu Gln Lys Val Lys Val Trp Leu Gln Glu Tyr Trp Asn Val Thr Asp Leu Ile Ala Ile Leu Leu Phe Ser Val Gly Met Ile Leu Arg Leu Gln Asp Gln Pro Phe Arg Ser Asp Gly Arg Val Ile Tyr Cys Val Asn Ile Ile Tyr Trp Tyr Ile Arg Leu Leu Asp Ile Phe Gly Val Asn Lys Tyr Leu Gly Pro Tyr Val Met Met Ile Gly Lys Met Met Ile Asp Met Met Tyr Phe Val Ile Ile Met Leu Val Val Leu Met Ser Phe Gly Val Ala Arg Gln Ala Ile Leu Phe Pro Asn Glu Glu Pro Ser Trp Lys Leu Ala Lys Asn Ile Phe Tyr Met Pro Tyr Trp Met Ile Tyr Gly Glu Val Phe Ala Asp Gln Ile Asp Arg Lys Gln Val Tyr Asp Ser His Thr Pro Lys Ser Gly Ile <210> 67 <211> 2064 <212> DNA
<213> homo Sapiens <400>

atgggcggggcttatcgctgcaactacacgcgcaagcgcttccggaccctctaccacaac 60 ctcttcggccccaagagggatgatattcccttgaggcgaggaagaaagacaaccaagaaa 120 cgtgaagaagaggtggacattgacttggatgatcctgagatcaaccacttccccttccct 180 ttccatgagctcatggtgtgggctgttctcatgaagcggcagaagatggccctgttcttc 240 tggcagcacggtgaggaggccatggccaaggccctggtggcctgcaagctctgcaaagcc 300 atggctcatgaggcctctgagaacgacatggttgacgacatttcccaggagctgaatcac 360 aattccagagactttggccagctggctgtggagctcctggaccagtcctacaagcaggac 420 gaacagctggccatgaaactgctgacgtatgagctgaagaactggagcaacgccacgtgc 480 ctgcagcttgccgtggctgccaaacaccgcgacttcatcgcgcacacgtgcagccagatg 540 ctgctcaccgacatgtggatgggccggctccgcatgcgcaagaactcaggcctcaaggta 600 attctgggaattctacttcctccttcaattctcagcttggagttcaagaacaaagacgac 660 atgccctatatgtctcaggcccaggaaatccacctccaagagaaggaggcagaagaacca 720 gagaagcccacaaaggaaaaagaggaagaggacatggagctcacagcaatgttgggacga 780 aacaacggggagtcctccaggaagaaggatgaagaggaagttcagagcaagcaccggtta 840 atccccctcggcagaaaaatctatgaattctacaatgcacccatcgtgaagttctggttc 900 tacacactggcgtatatcggatacctgatgctcttcaactatatcgtgttagtgaagatg 960 gaacgctggccgtccacccaggaatggatcgtaatctcctatattttcaccctgggaata 1020 gaaaagatgagagagattctgatgtcagagccagggaagttgctacagaaagtgaaggta 1080 tggctgcaggagtactggaatgtcacggacctcatcgccatccttctgttttctgtcgga 1140 atgatccttcgtctccaagaccagcccttcaggagtgacgggagggtcatctactgcgtg 1200 aacatcatttactggtatatccgtctcctagacatcttcggcgtgaacaagtatttgggc 1260 ccgtatgtaatgatgattggaaaaatgatgatagacatgatgtactttgtcatcattatg 1320 ctggtggttctgatgagctttggggtcgccaggcaagccatcctttttcccaatgaggag 1380 ccatcatggaaactggccaagaacatcttctacatgccctattggatgatttatggggaa 1440 gtgtttgcggaccagatagaccctccctgtggacagaatgagacccgagaggatggtaaa 1500 ataatccagctgcctccctgcaagacaggagcttggatcgtgccggccatcatggcctgc 1560 tacctcttagtggcaaacatcttgctggtcaacctcctcattgctgtctttaacaataca 1620 ttttttgaagtaaaatcgatatccaaccaagtctggaagtttcagaggtatcagctcatc 1680 atgactttccatgaaaggccagttctgcccccaccactgatcatcttcagccacatgacc 1740 atgatattccagcacctgtgctgccgatggaggaaacacgagagcgacccggatgaaagg 1800 gactacggcctgaaactcttcataaccgatgatgagctcaagaaagtacatgactttgaa 1860 gagcaatgcatagaagaatacttcagagaaaaggatgatcggttcaactcatctaatgat 1920 gagaggatacgggtgacttcagaaaggtgtgttctgtggacacctgcctcctgcagatgt 1980 gttgtgccaa ggcatgcttt atccatcgaa tttattcaca cggtcacaaa acagagatct 2040 tttgtgtttg tttttattgt ctga 2064 <210> 68 <211> 687 <212> PRT
<213> homo sapiens <400> 68 Met Gly Gly Ala Tyr Arg Cys Asn Tyr Thr Arg Lys Arg Phe Arg Thr Leu Tyr His Asn Leu Phe Gly Pro Lys Arg Asp Asp Ile Pro Leu Arg Arg Gly Arg Lys Thr Thr Lys Lys Arg Glu Glu Glu Val Asp Ile Asp Leu Asp Asp Pro Glu Ile Asn His Phe Pro Phe Pro Phe His Glu Leu Met Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala Leu Phe Phe Trp Gln His Gly Glu Glu Ala Met Ala Lys Ala Leu Val Ala Cys Lys Leu Cys Lys Ala Met Ala His Glu Ala Ser Glu Asn Asp Met Val Asp Asp Ile Ser Gln Glu Leu Asn His Asn Ser Arg Asp Phe Gly Gln Leu Ala Val Glu Leu Leu Asp Gln Ser Tyr Lys Gln Asp Glu Gln Leu Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ala Thr Cys Leu Gln Leu Ala Val Ala Ala Lys His Arg Asp Phe Ile Ala His Thr Cys Ser Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg Leu Arg Met Arg Lys Asn Ser Gly Leu Lys Val Ile Leu Gly Ile Leu Leu Pro Pro Ser Ile Leu Ser Leu Glu Phe Lys Asn Lys Asp Asp Met Pro Tyr Met Ser Gln Ala Gln Glu Ile His Leu Gln Glu Lys Glu Ala Glu Glu Pro Glu Lys Pro Thr Lys Glu Lys Glu Glu Glu Asp Met Glu Leu Thr Ala Met Leu Gly Arg Asn Asn Gly Glu Ser Ser Arg Lys Lys Asp Glu Glu Glu Val Gln Ser Lys His Arg Leu Ile Pro Leu Gly Arg Lys Ile Tyr Glu Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Leu Ala Tyr Ile Gly Tyr Leu Met Leu Phe Asn Tyr Ile Val Leu Val Lys Met Glu Arg Trp Pro Ser Thr Gln Glu Trp Ile Val Ile Ser Tyr Ile Phe Thr Leu Gly Ile Glu Lys Met Arg Glu Ile Leu Met Ser Glu Pro Gly Lys Leu Leu Gln Lys Val Lys Val Trp Leu Gln Glu Tyr Trp Asn Val Thr Asp Leu Ile Ala Ile Leu Leu Phe Ser Val Gly Met Ile Leu Arg Leu Gln Asp Gln Pro Phe Arg Ser Asp Gly Arg Val Ile Tyr Cys Val Asn Ile Ile Tyr Trp Tyr Ile Arg Leu Leu Asp Ile Phe Gly Val Asn Lys Tyr Leu Gly Pro Tyr Val Met Met Ile Gly Lys Met Met Ile Asp Met Met Tyr Phe Val Ile Ile Met Leu Val Val Leu Met Ser Phe Gly Val Ala Arg Gln Ala Ile Leu Phe Pro Asn Glu Glu Pro Ser Trp Lys Leu Ala Lys Asn Ile Phe Tyr Met Pro Tyr Trp Met Ile Tyr Gly Glu Val Phe Ala Asp Gln Ile Asp Pro Pro Cys Gly Gln Asn Glu Thr Arg Glu Asp Gly Lys Ile Ile Gln Leu Pro Pro Cys Lys Thr Gly Ala Trp Ile Val Pro Ala Ile Met Ala Cys Tyr Leu Leu Val Ala Asn Ile Leu Leu Val Asn Leu Leu Ile Ala Val Phe Asn Asn Thr Phe Phe Glu Val Lys Ser Ile Ser Asn Gln Val Trp Lys Phe Gln Arg Tyr Gln Leu Ile Met Thr Phe His Glu Arg Pro Val Leu Pro Pro Pro Leu Ile Ile Phe Ser His Met Thr Met Ile Phe Gln His Leu Cys Cys Arg Trp Arg Lys His Glu Ser Asp Pro Asp Glu Arg Asp Tyr Gly Leu Lys Leu Phe Ile Thr Asp Asp Glu Leu Lys Lys Val His Asp Phe Glu Glu Gln Cys Ile Glu Glu Tyr Phe Arg Glu Lys Asp Asp Arg Phe Asn Ser Ser Asn Asp Glu Arg Ile Arg Val Thr Ser Glu Arg Cys Val Leu Trp Thr Pro Ala Ser Cys Arg Cys Val Val Pro Arg His Ala Leu Ser Ile Glu Phe Ile His Thr Val Thr Lys Gln Arg Ser Phe Val Phe Val Phe Ile Val <210> 69 <211> 2253 <212> DNA
<213> homo sapiens <400> 69 atgggcggggcttatcgctgcaactacacgcgcaagcgcttccggaccctctaccacaac 60 ctcttcggccccaagagggatgatattcccttgaggcgaggaagaaagacaaccaagaaa 120 cgtgaagaagaggtggacattgacttggatgatcctgagatcaaccacttccccttccct 180 ttccatgagctcatggtgtgggctgttctcatgaagcggcagaagatggccctgttcttc 240 tggcagcacggtgaggaggccatggccaaggccctggtggcctgcaagctctgcaaagcc 300 atggctcatgaggcctctgagaacgacatggttgacgacatttcccaggagctgaatcac 360 aattccagagactttggccagctggctgtggagctcctggaccagtcctacaagcaggac 420 gaacagctggccatgaaactgctgacgtatgagctgaagaactggagcaacgccacgtgc 480 ctgcagcttgccgtggctgccaaacaccgcgacttcatcgcgcacacgtgcagccagatg 540 ctgctcaccgacatgtggatgggccggctccgcatgcgcaagaactcaggcctcaaggta 600 attctgggaattctacttcctccttcaattctcagcttggagttcaagaacaaagacgac 660 atgccctatatgtctcaggcccaggaaatccacctccaagagaaggaggcagaagaacca 720 gagaagcccacaaaggaaaaagaggaagaggacatggagctcacagcaatgttgggacga 780 aacaacggggagtcctccaggaagaaggatgaagaggaagttcagagcaagcaccggtta 840 atccccctcggcagaaaaatctatgaattctacaatgcacccatcgtgaagttctggttc 900 tacacactggcgtatatcggatacctgatgctcttcaactatatcgtgttagtgaagatg 960 gaacgctggccgtccacccaggaatggatcgtaatctcctatattttcaccctgggaata 1020 gaaaagatgagagagattctgatgtcagagccagggaagttgctacagaaagtgaaggta 1080 tggctgcaggagtactggaatgtcacggacctcatcgccatccttctgttttctgtcgga 1140 atgatccttcgtctccaagaccagcccttcaggagtgacgggagggtcatctactgcgtg 1200 aacatcatttactggtatatccgtctcctagacatcttcggcgtgaacaagtatttgggc 1260 ccgtatgtaatgatgattggaaaaatgatgatagacatgatgtactttgtcatcattatg 1320 ctggtggttctgatgagctttggggtcgccaggcaagccatcctttttcccaatgaggag 1380 ccatcatggaaactggccaagaacatcttctacatgccctattggatgatttatggggaa 1440 gtgtttgcggaccagatagaccctccctgtggacagaatgagacccgagaggatggtaaa 1500 ataatccagctgcctccctgcaagacaggagcttggatcgtgccggccatcatggcctgc 1560 tacctcttagtggcaaacatcttgctggtcaacctcctcattgctgtctttaacaataca 1620 ttttttgaagtaaaatcgatatccaaccaagtctggaagtttcagaggtatcagctcatc 1680 atgactttccatgaaaggccagttctgcccccaccactgatcatcttcagccacatgacc 1740 atgatattccagcacctgtgctgccgatggaggaaacacgagagcgacccggatgaaagg 1800 gactacggcctgaaactcttcataaccgatgatgagctcaagaaagtacatgactttgaa 1860 gagcaatgcatagaagaatacttcagagaaaaggatgatcggttcaactcatctaatgat 1920 gagaggatacgggtgacttcagaaagggtggagaacatgtctatgcggctggaggaagtc 1980 aacgagagagagcactccatgaaggcttcactccagaccgtggacatccggctggcgcag 2040 ctggaagaccttatcgggcgcatggccacggccctggagcgcctgacaggtctggagcgg 2100 gccgagtccaacaaaatccgctcgaggacctcgtcagactgcacggacgccgcctacatt 2160 gtccgtcagagcagcttcaacagccaggaagggaacaccttcaagctccaagagagtata 2220 gaccctgcagagcatcctctttattcagtataa 2253 <210> 70 <211> 750 <212> PRT
<213> homo Sapiens <400> 70 Met Gly Gly Ala Tyr Arg Cys Asn Tyr Thr Arg Lys Arg Phe Arg Thr Leu Tyr His Asn Leu Phe Gly Pro Lys Arg Asp Asp Ile Pro Leu Arg Arg Gly Arg Lys Thr Thr Lys Lys Arg Glu Glu Glu Val Asp Ile Asp Leu Asp Asp Pro Glu Ile Asn His Phe Pro Phe Pro Phe His Glu Leu Met Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala Leu Phe Phe Trp Gln His Gly Glu Glu Ala Met Ala Lys Ala Leu Val Ala Cys Lys Leu Cys Lys Ala Met Ala His Glu Ala Ser Glu Asn Asp Met Val Asp Asp Ile Ser Gln Glu Leu Asn His Asn Ser Arg Asp Phe Gly Gln Leu Ala Val Glu Leu Leu Asp Gln Ser Tyr Lys Gln Asp Glu Gln Leu Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ala Thr Cys Leu Gln Leu Ala Val Ala Ala Lys His Arg Asp Phe Ile Ala His Thr Cys Ser Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg Leu Arg Met Arg Lys Asn Ser Gly Leu Lys Val Ile Leu Gly Ile Leu Leu Pro Pro Ser Ile Leu Ser Leu Glu Phe Lys Asn Lys Asp Asp Met Pro Tyr Met Ser Gln Ala Gln Glu Ile His Leu Gln Glu Lys Glu Ala Glu Glu Pro Glu Lys Pro Thr Lys Glu Lys Glu Glu Glu Asp Met Glu Leu Thr Ala Met Leu Gly Arg Asn Asn Gly Glu Ser Ser Arg Lys Lys Asp Glu Glu Glu Val Gln Ser Lys His Arg Leu Ile Pro Leu Gly Arg Lys Ile Tyr Glu Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Leu Ala Tyr Ile Gly Tyr Leu Met Leu Phe Asn Tyr Ile Val Leu Val Lys Met Glu Arg Trp Pro Ser Thr Gln Glu Trp Ile Val Ile Ser Tyr Ile Phe Thr Leu Gly Ile Glu Lys Met Arg Glu Ile Leu Met Ser Glu Pro Gly Lys Leu Leu Gln Lys Val Lys Val Trp Leu Gln Glu Tyr Trp Asn Val Thr Asp Leu Ile Ala Ile Leu Leu Phe Ser Val Gly Met Ile Leu Arg Leu Gln Asp Gln Pro Phe Arg Ser Asp Gly Arg Val Ile Tyr Cys Val Asn Ile Ile Tyr Trp Tyr Ile Arg Leu Leu Asp Ile Phe Gly Val Asn Lys Tyr Leu Gly Pro Tyr Val Met Met Ile Gly Lys Met Met Ile Asp Met Met Tyr Phe Val Ile Ile Met Leu Val Val Leu Met Ser Phe Gly Val Ala Arg Gln Ala Ile Leu Phe Pro Asn Glu Glu Pro Ser Trp Lys Leu Ala Lys Asn Ile Phe Tyr Met Pro Tyr Trp Met Ile Tyr Gly Glu Val Phe Ala Asp Gln Ile Asp Pro Pro Cys Gly Gln Asn Glu Thr Arg Glu Asp Gly Lys Ile Ile Gln Leu Pro Pro Cys Lys Thr Gly Ala Trp Ile Val Pro Ala Ile Met Ala Cys Tyr Leu Leu Val Ala Asn Ile Leu Leu Val Asn Leu Leu Ile Ala Val Phe Asn Asn Thr Phe Phe Glu Val Lys Ser Ile Ser Asn Gln Val Trp Lys Phe Gln Arg Tyr Gln Leu Ile Met Thr Phe His Glu Arg Pro Val Leu Pro Pro Pro Leu Ile Ile Phe Ser His Met Thr Met Ile Phe Gln His Leu Cys Cys Arg Trp Arg Lys His Glu Ser Asp Pro Asp Glu Arg Asp Tyr Gly Leu Lys Leu Phe Ile Thr Asp Asp Glu Leu Lys Lys Val His Asp Phe Glu Glu Gln Cys Ile Glu Glu Tyr Phe Arg Glu Lys Asp Asp Arg Phe Asn Ser Ser Asn Asp Glu Arg Ile Arg Val Thr Ser Glu Arg Val Glu Asn Met Ser Met Arg Leu Glu Glu Val Asn Glu Arg Glu His Ser Met Lys Ala Ser Leu Gln Thr Val Asp Ile Arg Leu Ala Gln Leu Glu Asp Leu Ile Gly Arg Met Ala Thr Ala Leu Glu Arg Leu Thr Gly Leu Glu Arg Ala Glu Ser Asn Lys Ile Arg Ser Arg Thr Ser Ser Asp Cys Thr Asp Ala Ala Tyr Ile Val Arg Gln Ser Ser Phe Asn Ser Gln Glu Gly Asn Thr Phe Lys Leu Gln Glu Ser Ile Asp Pro Ala Glu His Pro Leu Tyr Ser Val <210> 71 <211> 3399 <212> DNA
<213> homo Sapiens <400> 71 atgggcgggg cttatcgctg caactacacg cgcaagcgct tccggaccct ctaccacaac 60 ctcttcggcc ccaagaggga tgatattccc ttgaggcgag gaagaaagac aaccaagaaa 120 cgtgaagaag aggtggacat tgacttggat gatcctgaga tcaaccactt ccccttccct 180 ttccatgagc tcatggtgtg ggctgttctc atgaagcggc agaagatggc cctgttcttc 240 tggcagcacggtgaggaggccatggccaaggccctggtggcctgcaagctctgcaaagcc 300 atggctcatgaggcctctgagaacgacatggttgacgacatttcccaggagctgaatcac 360 aattccagagactttggccagctggctgtggagctcctggaccagtcctacaagcaggac 420 gaacagctggccatgaaactgctgacgtatgagctgaagaactggagcaacgccacgtgc 480 ctgcagcttgccgtggctgccaaacaccgcgacttcatcgcgcacacgtgcagccagatg 540 ctgctcaccgacatgtggatgggccggctccgcatgcgcaagaactcaggcctcaaggta 600 attctgggaattctacttcctccttcaattctcagcttggagttcaagaacaaagacgac 660 atgccctatatgtctcaggcccaggaaatccacctccaagagaaggaggcagaagaacca 720 gagaagcccacaaaggaaaaagaggaagaggacatggagctcacagcaatgttgggacga 780 aacaacggggagtcctccaggaagaaggatgaagaggaagttcagagcaagcaccggtta 840 atccccctcggcagaaaaatctatgaattctacaatgcacccatcgtgaagttctggttc 900 tacacactggcgtatatcggatacctgatgctcttcaactatatcgtgttagtgaagatg 960 gaacgctggccgtccacccaggaatggatcgtaatctcctatattttcaccctgggaata 1020 gaaaagatgagagagattctgatgtcagagccagggaagttgctacagaaagtgaaggta 1080 tggctgcaggagtactggaatgtcacggacctcatcgccatccttctgttttctgtcgga 1140 atgatccttcgtctccaagaccagcccttcaggagtgacgggagggtcatctactgcgtg 1200 aacatcatttactggtatatccgtctcctagacatcttcggcgtgaacaagtatttgggc 1260 ccgtatgtaatgatgattggaaaaatgatgatagacatgatgtactttgtcatcattatg 1320 ctggtggttctgatgagctttggggtcgccaggcaagccatcctttttcccaatgaggag 1380 ccatcatggaaactggccaagaacatcttctacatgccctattggatgatttatggggaa 1440 gtgtttgcggaccagatagaccctccctgtggacagaatgagacccgagaggatggtaaa 1500 ataatccagctgcctccctgcaagacaggagcttggatcgtgccggccatcatggcctgc 1560 tacctcttagtggcaaacatcttgctggtcaacctcctcattgctgtctttaacaataca 1620 ttttttgaagtaaaatcgatatccaaccaagtctggaagtttcagaggtatcagctcatc 1680 atgactttccatgaaaggccagttctgcccccaccactgatcatcttcagccacatgacc 1740 atgatattccagcacctgtgctgccgatggaggaaacacgagagcgacccggatgaaagg 1800 gactacggcctgaaactcttcataaccgatgatgagctcaagaaagtacatgactttgaa 1860 gagcaatgcatagaagaatacttcagagaaaaggatgatcggttcaactcatctaatgat 1920 gagaggatacgggtgacttcagaaagggtggagaacatgtctatgcggctggaggaagtc 1980 aacgagagagagcactccatgaaggcttcactccagaccgtggacatccggctggcgcag 2040 ctggaagaccttatcgggcgcatggccacggccctggagcgcctgacaggtctggagcgg 2100 gccgagtccaacaaaatccgctcgaggacctcgtcagactgcacggacgccgcctacatt 2160 gtccgtcagagcagcttcaacagccaggaagggaacaccttcaagctccaagagagtata 2220 gaccctgcaggtgaggagaccatgtccccaacttctccaaccttaatgccccgtatgcga 2280 agccattctttctattcggtcaatatgaaagacaaaggtggtatagaaaagttggaaagt 2340 atttttaaagaaaggtccctgagcctacaccgggctactagttcccactctgtagcaaaa 2400 gaacccaaagctcctgcagcccctgccaacaccttggccattgttcctgattccagaaga 2460 ccatcatcgtgtatagacatctatgtctctgctatggatgagctccactgtgatatagac 2520 cctctggacaattccgtgaacatccttgggctaggcgagccaagcttttcaactccagta 2580 ccttccacagccccttcaagtagtgcctatgcaacacttgcacccacagacagacctcca 2640 agccggagcattgattttgaggacatcacctccatggacactagatctttttcttcagac 2700 tacacccacctcccagaatgccaaaacccctgggactcagagcctccgatgtaccacacc 2760 attgagcgttccaaaagtagccgctacctagccaccacaccctttcttctagaagaggct 2820 cccattgtgaaatctcatagctttatgttttccccctcaaggagctattatgccaacttt 2880 ggggtgcctgtaaaaacagcagaatacacaagtattacagactgtattgacacaaggtgt 2940 gtcaatgcccctcaagcaattgcggacagagctgccttccctggaggtcttggagacaaa 3000 gtggaggacttaacttgctgccatccagagcgagaagcagaactgagtcaccccagctct 3060 gacagtgaggagaatgaggccaaaggccgcagagccaccattgcaatatcctcccaggag 3120 ggtgataactcagagagaaccctgtccaacaacatcactgttcccaagatagagcgcgcc 3180 aacagctactcggcagaggagccaagtgcgccatatgcacacaccaggaagagcttctcc 3240 atcagtgacaaactcgacaggcagcggaacacagcaagcctgcgaaatcccttccagaga 3300 agcaagtcctccaagccggagggccgaggggacagcctgtccatgaggaaactgtccaga 3360 acatcggctttccaaagctttgaaagcaagcacacctaa 3399 <210> 72 <211> 1132 <212> PRT
<213> homo Sapiens <400> 72 Met Gly Gly Ala Tyr Arg Cys Asn Tyr Thr Arg Lys Arg Phe Arg Thr Leu Tyr His Asn Leu Phe Gly Pro Lys Arg Asp Asp Ile Pro Leu Arg Arg Gly Arg Lys Thr Thr Lys Lys Arg Glu Glu Glu Val Asp Ile Asp Leu Asp Asp Pro Glu Ile Asn His Phe Pro Phe Pro Phe His Glu Leu Met Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala Leu Phe Phe Trp Gln His Gly Glu Glu Ala Met Ala Lys Ala Leu Val Ala Cys Lys Leu Cys Lys Ala Met Ala His Glu Ala Ser Glu Asn Asp Met Val Asp Asp Ile Ser Gln Glu Leu Asn His Asn Ser Arg Asp Phe Gly Gln Leu Ala Val Glu Leu Leu Asp Gln Ser Tyr Lys Gln Asp Glu Gln Leu Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ala Thr Cys Leu Gln Leu Ala Val Ala Ala Lys His Arg Asp Phe Ile Ala His Thr Cys Ser Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg Leu Arg Met Arg Lys Asn Ser Gly Leu Lys Val Ile Leu Gly Ile Leu Leu Pro Pro Ser Ile Leu Ser Leu Glu Phe Lys Asn Lys Asp Asp Met Pro Tyr Met Ser Gln Ala Gln Glu Ile His Leu Gln Glu Lys Glu Ala Glu Glu Pro Glu Lys Pro Thr Lys Glu Lys Glu Glu Glu Asp Met Glu Leu Thr Ala Met Leu Gly Arg Asn Asn Gly Glu Ser Ser Arg Lys Lys Asp Glu Glu Glu Val Gln Ser Lys His Arg Leu Ile Pro Leu Gly Arg Lys Ile Tyr Glu Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Leu Ala Tyr Ile Gly Tyr Leu Met Leu Phe Asn Tyr Ile Val Leu Val Lys Met Glu Arg Trp Pro Ser Thr Gln Glu Trp Ile Val Ile Ser Tyr Ile Phe Thr Leu Gly Ile Glu Lys Met Arg Glu Ile Leu Met Ser Glu Pro Gly Lys Leu Leu Gln Lys Val Lys Val Trp Leu Gln Glu Tyr Trp Asn Val Thr Asp Leu Ile Ala Ile Leu Leu Phe Ser Val Gly Met Ile Leu Arg Leu Gln Asp Gln Pro Phe Arg Ser Asp Gly Arg Val Ile Tyr Cys Val Asn Ile Ile Tyr Trp Tyr Ile Arg Leu Leu Asp Ile Phe Gly Val Asn Lys Tyr Leu Gly Pro Tyr Val Met Met Ile Gly Lys Met Met Ile Asp Met Met Tyr Phe Val Ile Ile Met Leu Val Val Leu Met Ser Phe Gly Val Ala Arg Gln Ala Ile Leu Phe Pro Asn Glu Glu Pro Ser Trp Lys Leu Ala Lys Asn Ile Phe Tyr Met Pro Tyr Trp Met Ile Tyr Gly Glu Val Phe Ala Asp Gln Ile Asp Pro Pro Cys Gly Gln Asn Glu Thr Arg Glu Asp Gly Lys Ile Ile Gln Leu Pro Pro Cys Lys Thr Gly Ala Trp Ile Val Pro Ala Ile Met Ala Cys Tyr Leu Leu Val Ala Asn Ile Leu Leu Val Asn Leu Leu Ile Ala Val Phe Asn Asn Thr Phe Phe Glu Val Lys Ser Ile Ser Asn Gln Val Trp Lys Phe Gln Arg Tyr Gln Leu Ile Met Thr Phe His Glu Arg Pro Val Leu Pro Pro Pro Leu Ile Ile Phe Ser His Met Thr Met Ile Phe Gln His Leu Cys Cys Arg Trp Arg Lys His Glu Ser Asp Pro Asp Glu Arg Asp Tyr Gly Leu Lys Leu Phe Ile Thr Asp Asp Glu Leu Lys Lys Val His Asp Phe Glu Glu Gln Cys Ile Glu Glu Tyr Phe Arg Glu Lys Asp Asp Arg Phe Asn Ser Ser Asn Asp Glu Arg Ile Arg Val Thr Ser Glu Arg Val Glu Asn Met Ser Met Arg Leu Glu Glu Val Asn Glu Arg Glu His Ser Met Lys Ala Ser Leu Gln Thr Val Asp Ile Arg Leu Ala Gln Leu Glu Asp Leu Ile Gly Arg Met Ala Thr Ala Leu Glu Arg Leu Thr Gly Leu Glu Arg Ala Glu Ser Asn Lys Ile Arg Ser Arg Thr Ser Ser Asp Cys Thr Asp Ala Ala Tyr Ile Val Arg Gln Ser Ser Phe Asn Ser Gln Glu Gly Asn Thr Phe Lys Leu Gln Glu Ser Ile Asp Pro Ala Gly Glu Glu Thr Met Ser Pro Thr Ser Pro Thr Leu Met Pro Arg Met Arg Ser His Ser Phe Tyr Ser Val Asn Met Lys Asp Lys Gly Gly Ile Glu Lys Leu Glu Ser Ile Phe Lys Glu Arg Ser Leu Ser Leu His Arg Ala Thr Ser Ser His Ser Val Ala Lys Glu Pro Lys Ala Pro Ala Ala Pro Ala Asn Thr Leu Ala Ile Val Pro Asp Ser Arg Arg Pro Ser Ser Cys Ile Asp Ile Tyr Val Ser Ala Met Asp Glu Leu His Cys Asp Ile Asp Pro Leu Asp Asn Ser Val Asn Ile Leu Gly Leu Gly Glu Pro Ser Phe Ser Thr Pro Val Pro Ser Thr Ala Pro Ser Ser Ser Ala Tyr Ala Thr Leu Ala Pro Thr Asp Arg Pro Pro Ser Arg Ser Ile Asp Phe Glu Asp Ile Thr Ser Met Asp Thr Arg Ser Phe Ser Ser Asp Tyr Thr His Leu Pro Glu Cys Gln Asn Pro Trp Asp Ser Glu Pro Pro Met Tyr His Thr Ile Glu Arg Ser Lys Ser Ser Arg Tyr Leu Ala Thr Thr Pro Phe Leu Leu Glu Glu Ala Pro Ile Val Lys Ser His Ser Phe Met Phe Ser Pro Ser Arg Ser Tyr Tyr Ala Asn Phe Gly Val Pro Val Lys Thr Ala Glu Tyr Thr Ser Ile Thr Asp Cys Ile Asp Thr Arg Cys Val Asn Ala Pro Gln Ala Ile Ala Asp Arg Ala Ala Phe Pro Gly Gly Leu Gly Asp Lys Val Glu Asp Leu Thr Cys Cys His Pro Glu Arg Glu Ala Glu Leu Ser His Pro Ser Ser Asp Ser Glu Glu Asn Glu Ala Lys Gly Arg Arg Ala Thr Ile Ala Ile Ser Ser Gln Glu Gly Asp Ser ArgThr LeuSerAsn AsnIleThr ValProLys Asn Glu Ile Glu Ala SerTyr SerAlaGlu GluProSer AlaProTyr Arg Asn Ala His Arg SerPhe SerIleSer AspLysLeu AspArgGln Thr Lys Arg Asn Ala LeuArg AsnProPhe GlnArgSer LysSerSer Thr Ser Lys Pro Gly GlyAsp SerLeuSer MetArgLys LeuSerArg Glu Arg Thr Ser Phe SerPhe GluSerLys HisThr Ala Gln <210>

<211>

<212>
DNA

<213> sapiens homo <400>

atgctggggctcctgggcct agcactgtat tgtgtctcct tacagctggc 60 gaacagccag gtatatcggatacctgatgc tatcgtgtta gtgaagatgg aacgctggcc tcttcaacta gtccacccaggaatggatcg tattttcacc cttgttccag ctggttgtct taatctccta gcacttcggtcttcccattc ttcttcttga ccaatgttgt ggatttccca atggtgcctt tttgtaaacttttcctctgc 270 ggctcagtga <210>

<211>

<212>
PRT

<213> sapiens homo <400>

Met Leu Leu GlyLeu AsnSerGln SerThrVal LeuCysLeu Gly Leu Leu Thr Gly TyrArg IleProAsp AlaLeuGln LeuTyrArg Ala Val Val Ser Asp ThrLeu AlaValHis ProGlyMet AspArgAsn Glu Gly Leu Leu Phe ProCys SerSerTrp LeuSerAla LeuArgSer Tyr His Ser His Trp LeuPhe PheLeuThr AsnValVal AspPhePro Ser Cys Phe Val Phe SerAla AlaGln Asn Ser <210> 75 <211> 384 <212> DNA
<213> homo sapiens <400> 75 atgctggggc tcctgggcct gaacagccag agcactgtat tgtgtctcct tacagctggc 60 gtatatcgga tacctgatgc tcttcaacta tatcgtgtta gtgaagatgg aacgctggcc 120 gtccacccag gaatggatcg taatctccta tattttcacc ctgggaatag aaaagatgag 180 agaggtaacg gcttttataa aagaaaacgt aagagaaaga cagtggttaa gttctatctg 240 tggatggagg ggacaggaag atgcctggga tgcaaattaa gccggaaact gttttctcta 300 actctaccac agctgcttct ttgctcctct gacaaacctg gggaggcttc acagtgtggt 360 gcttataggg gtgtaactcc ctga 384 <210> 76 <211> 127 <212> PRT
<213> homo sapiens <400>

Met Leu Leu GlyLeuAsn SerGln SerThrValLeu CysLeu Gly Leu Leu Thr Gly TyrArgIle ProAsp AlaLeuGlnLeu TyrArg Ala Val Val Ser Asp ThrLeuAla ValHis ProGlyMetAsp ArgAsn Glu Gly Leu Leu Phe ProGlyAsn ArgLys AspGluArgGly AsnGly Tyr His Phe Tyr Arg ArgLysArg LysThr ValValLysPhe TyrLeu Lys Lys Trp Met Gly GlyArgCys LeuGly CysLysLeuSer ArgLys Glu Thr Leu Phe Leu LeuProGln LeuLeu LeuCysSerSer AspLys Ser Thr Pro Gly Ala GlnCysGly AlaTyr ArgGlyValThr Pro Glu Ser <210>

<211>

<212>
DNA

<213> Sapiens homo <400>

atgctggggctcctgggcct agcactgtat tgtgtctcct tacagctggc gaacagccag gtatatcggatacctgatgc tatcgtgtta gtgaagatgg aacgctggcc tcttcaacta gtccacccaggaatggatcg tattttcacc ctgggaatag aaaagatgag taatctccta agagattctgatgtcagagc gctacagaaa gtgaaggtat ggctgcagga cagggaagtt gtactggaatgtcacggacc ccttctgttt tctgtcggaa tgatccttcg tcatcgccat tctccaagaccagcccttca 327 ggagtga <210>

<211>

<212>
PRT

<213> Sapiens homo <400>

Met Leu Leu GlyLeuAsn SerGln SerThrValLeu CysLeu Gly Leu Leu Thr Gly TyrArgIle ProAsp AlaLeuGlnLeu TyrArg Ala Val Val Ser Asp ThrLeuAla ValHis ProGlyMetAsp ArgAsn Glu Gly Leu Leu Phe ProGlyAsn ArgLys AspGluArgAsp SerAsp Tyr His Val Arg Arg ValAlaThr GluSer GluGlyMetAla AlaGly Ala Glu Val Leu Cys GlyProHis ArgHis ProSerValPhe CysArg Glu His Asn Asp Ser ProArgPro AlaLeu GlnGlu Pro Ser <210>

<211>

<212>
DNA

<213> Sapiens homo <400>

atgtgtccacatcataccca cccccatag 39 gcaccaaaga <210>

<211>

<212>
PRT

<213> homo sapiens <400> 80 Met Cys Pro His His Thr Gln His Gln Arg Pro Pro <210>

<211>

<212>
DNA

<213> sapiens homo <400>

atgttggcctcacccccagt atctccgtgcttcagaatgagaaaaatgaaagtcgcctct60 cccgaaatgacatccagtct gaaaagtggtccatcagcaaacacactcaactcagcccta120 cggatgcttttgggaccatt gagttccaaggaggtggccattccaacaaagccatgtatg180 tgcgagtatcttttgataca aaacctgatctcctcttacacctga 225 <210>

<211>

<212>
PRT

<213> sapiens homo <400>

Met Leu Ser Pro Pro Val Pro Cys Arg Met Lys Met Ala Ser Phe Arg Lys Val Ser Pro Glu Met Ser Ser Lys Ser Pro Ser Ala Thr Leu Gly Ala Asn Leu Asn Ser Ala Arg Met Leu Gly Leu Ser Thr Leu Leu Pro Ser Lys Val Ala Ile Pro Lys Pro Met Cys Tyr Leu Glu Thr Cys Glu Leu Ile Asn Leu Ile Ser Tyr Thr Gln Ser <210>

<211>

<212>
DNA

<213> sapiens homo <400>

atgtacaggtcaaaaggaag attgcatattataatccttcaagtattactgtcttttcta60 attcttttgttagtttag , 78 <210>

<211>

<212>
PRT

<213> sapiens homo <400>

Met Tyr Ser Lys Gly Arg His Ile Ile Leu Val Leu Arg Leu Ile Gln Leu Ser Leu Ile Leu Leu Val Phe Leu <210>

<211>

<212>
DNA

<213> sapiens homo <400>

aacaggagctgctccgggga ctgcttttgccagtacccagaatcagtgctcaggctcaga60 aatcctggatagaaagagca ttttataaaagagaatgtgtccacatcatacccagcacca120 aagacccccataggtgttgc tgtgggcgtctgataggccagcatgttggcctcaccccca180 gtatctccgtgcttcagaatgagaaaaatgaaagtcgcctctcccgaaatgacatccagt 240 ctgaaaagtggtccatcagcaaacacactcaactcagccctacggatgcttttgggacca 300 ttgagttccaaggaggtggccattccaacaaagccatgtatgtgcgagtatcttttgata 360 caaaacctgatctcctcttacacctgatgaccaaggaatggcagttggagcttcccaagc 420 ttctcatctctgtccatgggggcctgcagaactttgaactccagccaaaactcaagcaag 480 tctttgggaaagggctcatcaaagcagcaatgacaactggagcgtggatattcactggag 540 gggttaacacaggtgttattcgtcatgttggcgatgccttgaaggatcatgcctctaagt 600 ctcgaggaaagatatgcaccataggtattgccccctggggaattgtggaaaaccaggagg 660 acctcattggaagagatgttgtccggccataccagaccatgtccaatcccatgagcaagc 720 tcactgttctcaacagcatgcattcccacttcattctggctgacaacgggaccactggaa 780 aatatggagcagaggtgaaacttcgaagacaactggaaaagcatatttcactccagaaga 840 taaacacaagatgcctgccgtttttctctcttgactcccgcttgttttattcattttggg 900 gtagttgccagttagactcagttggaatcggtcaaggtgttcctgtggtggcactcatag 960 tggaaggaggacccaatgtgatctcgattgttttggagtaccttcgagacacccctcccg 1020 tgccagtggttgtctgtgatgggagtggacgggcatcggacatcctggcctttgggcata 1080 aatactcagaagaaggcggactgataaatgaatctttgagggaccagctgttggtgacta 1140 tacagaagactttcacatacactcgaacccaagctcagcatctgttcatcatcctcatgg 1200 agtgcatgaagaagaaggaattgattacggtatttcggatgggatcagaaggacaccagg 1260 acattgatttggctatcctgacagctttactcaaaggagccaatgcctcggccccagacc 1320 aactgagcttagctttagcctggaacagagtcgacatcgctcgcagccagatctttattt 1380 acgggcaacagtggccggtgggatctctggagcaagccatgttggatgccttagttctgg 1440 acagagtggattttgtgaaattactcatagagaatggagtaagcatgcaccgttttctca 1500 ccatctccagactagaggaattgtacaatacgagacatgggccctcaaatacattgtacc 1560 acttggtcagggatgtcaaaattcattattttttttttactctagttacagaatacgtga 1620 actagaatccctagtaaaccacgttgtcttttggatttgtctgtttgtttcattctaccc 1680 tgataggggaacctgcccccagactacagaatcagcctgattgacatcggcctggtgatc 1740 gagtacctgatgggcggggcttatcgctgcaactacacgcgcaagcgcttccggaccctc 1800 taccacaacctcttcggccccaagaggcccaaagccttgaaactgctgggaatggaggat 1860 gatattcccttgaggcgaggaagaaagacaaccaagaaacgtgaagaagaggtggacatt 1920 gacttggatgatcctgagatcaaccacttccccttccctttccatgagctcatggtgtgg 1980 gctgttctcatgaagcggcagaagatggccctgttcttctggcagcacggtgaggaggcc 2040 atggccaaggccctggtggcctgcaagctctgcaaagccatggctcatgaggcctctgag 2100 aacgacatggttgacgacatttcccaggagctgaatcacaattccagagactttggccag 2160 ctggctgtggagctcctggaccagtcctacaagcaggacgaacagctggccatgaaactg 2220 ctgacgtatgagctgaagaactggagcaacgccacgtgcctgcagcttgccgtggctgcc 2280 aaacaccgcgacttcatcgcgcacacgtgcagccagatgctgctcaccgacatgtggatg 2340 ggccggctccgcatgcgcaagaactcaggcctcaaggtaattctgggaattctacttcct 2400 ccttcaattctcagcttggagttcaagaacaaagacgacatgccctatatgtctcaggcc 2460 caggaaatccacctccaagagaaggaggcagaagaaccagagaagcccacaaaggaaaaa 2520 gaggaagaggacatggagctcacagcaatgttgggacgaaacaacggggagtcctccagg 2580 aagaaggatgaagaggaagttcagagcaagcaccggttaatccccctcggcagaaaaatc 2640 tatgaattctacaatgcacccatcgtgaagttctggttctacacattttttttttttgat 2700 gcatcatgacacatagatttaaacgaagcaccagagccccagagatacatgtacaggtca 2760 aaaggaagattgcatattataatccttcaagtattactgtcttttctaattcttttgtta 2820 gtttagcaccttcaagttccttttgtcataaagtctgtgtcctgcttgctgaccctgctc 2880 tgtgctgctgtgcagtggccttggctgatgctggggctcctgggcctgaacagccagagc 2940 actgtattgtgtctccttacagctggcgtatatcggatacctgatgctcttcaactatat 3000 cgtgttagtgaagatggaacgctggccgtccacccaggaatggatcgtaatctcctatat 3060 tttcacccttgttccagctggttgtctgcacttcggtcttcccattcatggtgccttttc 3120 ttcttgaccaatgttgtggatttcccatttgtaaacttttcctctgcggctcagtgaggc 3180 ggcgccccaacccctgtgtcctgccccactgaagagttgcttgacgaccaaagggtgagg 3240 accccacaggccatgcccttcctgcctcttcacagtcagcacgcaggacctccagggctc 3300 agacgcaagatcgggaatagaaaagatgagagaggtaacggcttttataaaagaaaacgt 3360 aagagaaagacagtggttaagttctatctgtggatggaggggacaggaagatgcctggga 3420 tgcaaattaagccggaaactgttttctctaactctaccacagctgcttctttgctcctct 3480 gacaaacctggggaggcttcacagtgtggtgcttataggggtgtaactccctgagtgctt 3540 aggatttggtctattctctgctaacgtagcctttgtcccaagaaggcctctagttgtttt 3600 tgatgcctcatccctataaacatgactttctagattttgccacttttaactcccatttct 3660 cccccttattctgggtgtcttcggacacagtctgccaatacctgtgactctctggatgta 3720 tttcggctgctttaggaggaactctgctttcactcactggattggatttaatctctgggt 3780 tattttcttaacattctgctcgtacctgctgggcaccaaccactctgccagcaggaggga 3840 ccaccaaggtgaactgaacacagatccttcaggttgtgagtgcagggtccctctttctcc 3900 cccacttctaattctgatgtcagagccagggaagttgctacagaaagtgaaggtatggct 3960 gcaggagtactggaatgtcacggacctcatcgccatccttctgttttctgtcggaatgat 4020 ccttcgtctccaagaccagcccttcaggagtgacgggagggtcatctactgcgtgaacat 4080 catttactggtatatccgtctcctagacatcttcggcgtgaacaagtatttgggcccgta 4140 tgtaatgatgattggaaaaatgatgatagacatgatgtactttgtcatcattatgctggt 4200 ggttctgatgagctttggggtcgccaggcaagccatcctttttcccaatgaggagccatc 4260 atggaaactggccaagaacatcttctacatgccctattggatgatttatggggaagtgtt 4320 tgcggaccagatagaccgtaagcaagtttatgattctcatacaccaaagtcaggtattta 4380 aattcaattcggttatgtcttttccaagtcatttggttggtctcaataaatggctcaaga 4440 tagaaaaaaaaaaaaactccctgtggacagaatgagacccgagaggatggtaaaataatc 4500 cagctgcctccctgcaagacaggagcttggatcgtgccggccatcatggcctgctacctc 4560 ttagtggcaaacatcttgctggtcaacctcctcattgctgtctttaacaatacatttttt 4620 gaagtaaaatcgatatccaaccaagtctggaagtttcagaggtatcagctcatcatgact 4680 ttccatgaaaggccagttctgcccccaccactgatcatcttcagccacatgaccatgata 4740 ttccagcacctgtgctgccgatggaggaaacacgagagcgacccggatgaaagggactac 4800 ggcctgaaactcttcataaccgatgatgagctcaagaaagtacatgactttgaagagcaa 4860 tgcatagaagaatacttcagagaaaaggatgatcggttcaactcatctaatgatgagagg 4920 atacgggtgacttcagaaaggtgtgttctgtggacacctgcctcctgcagatgtgttgtg 4980 ccaaggcatgctttatccatcgaatttattcacacggtcacaaaacagagatcttttgtg 5040 tttgtttttattgtctgagaaatcatggagcttatgagagaacagaacattgccaaagta 5100 tctatagatcaaaatcccagacttacagatcctagacttctctagcaggcagtagcagct 5160 gtcctcccagacagaagagaattttgagtgcaggacaggcctgaggttgctggctcagat 5220 caagaaattgggaagttctgttccaggcaaaaaccaaatgagactcaacctgactctagg 5280 ctctccattagttatgtttggaactattgcacgtcttttcagaggagttgaacagcccta 5340 gtgcctgccttatatgggtgcccaacaccttctgaataaatgacagttacagaattgtaa 5400 ttagctcgtggagaacatgtctatgcggctggaggaagtcaacgagagagagcactccat 5460 gaaggcttcactccagaccgtggacatccggctggcgcagctggaagaccttatcgggcg 5520 catggccacggccctggagcgcctgacaggtctggagcgggccgagtccaacaaaatccg 5580 ctcgaggacctcgtcagactgcacggacgccgcctacattgtccgtcagagcagcttcaa 5640 cagccaggaagggaacaccttcaagctccaagagagtatagaccctgcagagcatcctct 5700 ttattcagtataagccggcagcaagcagttctacctaacgtcccacatccttctcatgcc 5760 aacacgtgaggagaccatgtccccaacttctccaaccttaatgccccgtatgcgaagcca 5820 ttctttctattcggtcaatatgaaagacaaaggtggtatagaaaagttggaaagtatttt 5880 taaagaaaggtccctgagcctacaccgggctactagttcccactctgtagcaaaagaacc 5940 caaagctcctgcagcccctgccaacaccttggccattgttcctgattccagaagaccatc 6000 atcgtgtatagacatctatgtctctgctatggatgagctccactgtgatatagaccctct 6060 ggacaattccgtgaacatccttgggctaggcgagccaagcttttcaactccagtaccttc 6120 cacagccccttcaagtagtgcctatgcaacacttgcacccacagacagacctccaagccg 6180 gagcattgattttgaggacatcacctccatggacactagatctttttcttcagactacac 6240 ccacctcccagaatgccaaaacccctgggactcagagcctccgatgtaccacaccattga 6300 gcgttccaaaagtagccgctacctagccaccacaccctttcttctagaagaggctcccat 6360 tgtgaaatctcatagctttatgttttccccctcaaggagctattatgccaactttggggt 6420 gcctgtaaaaacagcagaatacacaagtattacagactgtattgacacaaggtgtgtcaa 6480 tgcccctcaagcaattgcggacagagctgccttccctggaggtcttggagacaaagtgga 6540 ggacttaacttgctgccatccagagcgagaagcagaactgagtcaccccagctctgacag 6600 tgaggagaatgaggccaaaggccgcagagccaccattgcaatatcctcccaggagggtga 6660 taactcagagagaaccctgtccaacaacatcactgttcccaagatagagcgcgccaacag 6720 ctactcggcagaggagccaagtgcgccatatgcacacaccaggaagagcttctccatcag 6780 tgacaaactcgacaggcagcggaacacagcaagcctgcgaaatcccttccagagaagcaa 6840 gtcctccaagccggagggccgaggggacagcctgtccatgaggaaactgtccagaacatc 6900 ggctttccaaagctttgaaagcaagcacacctaaaccttcttaatatccgccacagaagg 6960 ctcaagaatccagccctaaaattctctccaactccagtttttcccctttccttgaatcat 7020 acctgctttattcttagctgagcaaaacaagcaatgctttgggaggtgttaactcaaagg 7080 tgacttctgggccacagatcaagaaagcatttgatctgacccagtgccagacacagggga 7140 tttaaggcatgttcacacttgctgggcagggagggggaagagagggagaaggaagggtta 7200 gagatgaatgtgtatccgcagtcacagcagaaagccatgagagcaggggaaacaaggggc 7260 ttcgagcacgctccatgccaggaggcatctgttgatttctgaccattatcaagagttgta 7320 ggatgcagggctaaattgcaaaataaaataaaatagccagcgtacacaatgagatattct 7380 aaacttccattctgttttcttttcacattggctccatcactggtgactgatgaagagcat 7440 cctcttatcagtataagccggcagcaagcagttctacctaacgtccacatccttctcatg 7500 ccaacacttctgtat 7515

Claims (4)

WHAT IS CLAIMED IS:

1. An isolated nucleic acid molecule comprising at least 24 contiguous bases of nucleotide sequence first disclosed in the NHP gene described in SEQ ID NO: 23.

2. An isolated nucleic acid molecule comprising a nucleotide sequence that:
(a) encodes the amino acid sequence shown in SEQ ID
NO: 24; and (b) hybridizes under stringent conditions to the nucleotide sequence of SEQ ID NO: 23 or the complement thereof.

3. An isolated nucleic acid molecule comprising a nucleotide sequence that:
(a) encodes the amino acid sequence shown in SEQ ID
NO: 2; and (b) hybridizes under stringent conditions to the nucleotide sequence of SEQ ID NO: 1 or the complement thereof.

4. An isolated nucleic acid molecule comprising a nucleotide sequence that:
(a) encodes the amino acid sequence shown in SEQ ID
NO: 48; and (b) hybridizes under stringent conditions to the nucleotide sequence of SEQ ID NO: 47 or the complement thereof.