CA2381996A1 - Neutron brachytherapy device and method - Google Patents
Neutron brachytherapy device and method Download PDFInfo
- Publication number
- CA2381996A1 CA2381996A1 CA002381996A CA2381996A CA2381996A1 CA 2381996 A1 CA2381996 A1 CA 2381996A1 CA 002381996 A CA002381996 A CA 002381996A CA 2381996 A CA2381996 A CA 2381996A CA 2381996 A1 CA2381996 A1 CA 2381996A1
- Authority
- CA
- Canada
- Prior art keywords
- neutron
- capsule
- source
- wire
- guide wire
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000002725 brachytherapy Methods 0.000 title claims abstract description 33
- 238000000034 method Methods 0.000 title claims description 19
- 239000002775 capsule Substances 0.000 claims abstract description 118
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 90
- 239000000463 material Substances 0.000 claims abstract description 65
- 239000007789 gas Substances 0.000 claims abstract description 35
- 239000001307 helium Substances 0.000 claims abstract description 20
- 229910052734 helium Inorganic materials 0.000 claims abstract description 20
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 claims abstract description 19
- 229910052686 Californium Inorganic materials 0.000 claims abstract description 14
- HGLDOAKPQXAFKI-UHFFFAOYSA-N californium atom Chemical compound [Cf] HGLDOAKPQXAFKI-UHFFFAOYSA-N 0.000 claims abstract description 14
- 210000004881 tumor cell Anatomy 0.000 claims description 44
- 229910052751 metal Inorganic materials 0.000 claims description 8
- 239000002184 metal Substances 0.000 claims description 8
- 239000008188 pellet Substances 0.000 claims description 5
- 239000012857 radioactive material Substances 0.000 claims description 3
- 210000001124 body fluid Anatomy 0.000 claims 1
- RVTZCBVAJQQJTK-UHFFFAOYSA-N oxygen(2-);zirconium(4+) Chemical compound [O-2].[O-2].[Zr+4] RVTZCBVAJQQJTK-UHFFFAOYSA-N 0.000 claims 1
- 239000002861 polymer material Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 abstract description 27
- 210000004027 cell Anatomy 0.000 description 59
- 230000005855 radiation Effects 0.000 description 47
- 238000011282 treatment Methods 0.000 description 44
- 238000010586 diagram Methods 0.000 description 27
- 239000002245 particle Substances 0.000 description 18
- 208000003174 Brain Neoplasms Diseases 0.000 description 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 238000001356 surgical procedure Methods 0.000 description 7
- 238000002512 chemotherapy Methods 0.000 description 6
- 201000010099 disease Diseases 0.000 description 6
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 5
- 210000004556 brain Anatomy 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 4
- 206010021143 Hypoxia Diseases 0.000 description 4
- 229910052796 boron Inorganic materials 0.000 description 4
- 238000009826 distribution Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000001257 hydrogen Substances 0.000 description 4
- 229910052739 hydrogen Inorganic materials 0.000 description 4
- 230000001146 hypoxic effect Effects 0.000 description 4
- 238000001959 radiotherapy Methods 0.000 description 4
- 230000008439 repair process Effects 0.000 description 4
- 238000003466 welding Methods 0.000 description 4
- ZOXJGFHDIHLPTG-BJUDXGSMSA-N Boron-10 Chemical compound [10B] ZOXJGFHDIHLPTG-BJUDXGSMSA-N 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 231100000481 chemical toxicant Toxicity 0.000 description 3
- 238000005538 encapsulation Methods 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 230000002285 radioactive effect Effects 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 239000003440 toxic substance Substances 0.000 description 3
- 201000010915 Glioblastoma multiforme Diseases 0.000 description 2
- 150000001639 boron compounds Chemical class 0.000 description 2
- 230000022534 cell killing Effects 0.000 description 2
- 230000002498 deadly effect Effects 0.000 description 2
- 230000034994 death Effects 0.000 description 2
- 231100000517 death Toxicity 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 230000005670 electromagnetic radiation Effects 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 208000005017 glioblastoma Diseases 0.000 description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 230000002147 killing effect Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000009203 neutron therapy Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 206010018338 Glioma Diseases 0.000 description 1
- HBBGRARXTFLTSG-UHFFFAOYSA-N Lithium ion Chemical compound [Li+] HBBGRARXTFLTSG-UHFFFAOYSA-N 0.000 description 1
- 101100208721 Mus musculus Usp5 gene Proteins 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 229910000566 Platinum-iridium alloy Inorganic materials 0.000 description 1
- 206010057362 Underdose Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- MHTWJRZSIXRPPW-UHFFFAOYSA-H [Cf+3].[Cf+3].[O-]C(=O)C([O-])=O.[O-]C(=O)C([O-])=O.[O-]C(=O)C([O-])=O Chemical compound [Cf+3].[Cf+3].[O-]C(=O)C([O-])=O.[O-]C(=O)C([O-])=O.[O-]C(=O)C([O-])=O MHTWJRZSIXRPPW-UHFFFAOYSA-H 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 210000004958 brain cell Anatomy 0.000 description 1
- 210000005013 brain tissue Anatomy 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000005553 drilling Methods 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- -1 helium ion Chemical class 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 229910001416 lithium ion Inorganic materials 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- HLXZNVUGXRDIFK-UHFFFAOYSA-N nickel titanium Chemical compound [Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni] HLXZNVUGXRDIFK-UHFFFAOYSA-N 0.000 description 1
- 229910001000 nickel titanium Inorganic materials 0.000 description 1
- 210000004789 organ system Anatomy 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- HWLDNSXPUQTBOD-UHFFFAOYSA-N platinum-iridium alloy Chemical class [Ir].[Pt] HWLDNSXPUQTBOD-UHFFFAOYSA-N 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 238000009121 systemic therapy Methods 0.000 description 1
- 238000011277 treatment modality Methods 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1027—Interstitial radiation therapy
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G4/00—Radioactive sources
- G21G4/02—Neutron sources
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G4/00—Radioactive sources
- G21G4/04—Radioactive sources other than neutron sources
- G21G4/06—Radioactive sources other than neutron sources characterised by constructional features
- G21G4/08—Radioactive sources other than neutron sources characterised by constructional features specially adapted for medical application
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N2005/1019—Sources therefor
- A61N2005/1025—Wires
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1085—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
- A61N2005/109—Neutrons
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- High Energy & Nuclear Physics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Chemical & Material Sciences (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Radiation-Therapy Devices (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/395,324 US6352500B1 (en) | 1999-09-13 | 1999-09-13 | Neutron brachytherapy device and method |
| US09/395,324 | 1999-09-13 | ||
| PCT/US2000/025132 WO2001019450A2 (en) | 1999-09-13 | 2000-09-13 | Neutron brachytherapy device and method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2381996A1 true CA2381996A1 (en) | 2001-03-22 |
Family
ID=23562556
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002381996A Abandoned CA2381996A1 (en) | 1999-09-13 | 2000-09-13 | Neutron brachytherapy device and method |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US6352500B1 (enExample) |
| EP (1) | EP1218061B1 (enExample) |
| JP (1) | JP4574925B2 (enExample) |
| AT (1) | ATE555826T1 (enExample) |
| AU (1) | AU778456B2 (enExample) |
| CA (1) | CA2381996A1 (enExample) |
| IL (2) | IL148634A0 (enExample) |
| NZ (1) | NZ518274A (enExample) |
| WO (1) | WO2001019450A2 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6551232B1 (en) * | 1999-08-19 | 2003-04-22 | New England Medical Center | Dosimetry for californium-252(252Cf) neutron-emitting brachytherapy sources and encapsulation, storage, and clinical delivery thereof |
| US6352500B1 (en) * | 1999-09-13 | 2002-03-05 | Isotron, Inc. | Neutron brachytherapy device and method |
| US6786858B2 (en) * | 2001-11-02 | 2004-09-07 | Ideamatrix, Inc. | Delivery system and method for interstitial radiotherapy using hollow seeds |
| US7342988B2 (en) * | 2002-02-06 | 2008-03-11 | The Regents Of The University Of California | Neutron tubes |
| EP1551509B1 (en) | 2002-09-10 | 2008-10-29 | Cianna Medical, Inc. | Brachytherapy apparatus |
| US7093476B2 (en) * | 2004-09-15 | 2006-08-22 | Ut-Battelle, Llc | Method for fabricating thin californium-containing radioactive source wires |
| US7077800B2 (en) * | 2004-09-15 | 2006-07-18 | Ut Battelle, Llc | Cable attachment for a radioactive brachytherapy source capsule |
| US20080004482A1 (en) * | 2006-06-30 | 2008-01-03 | Eddie Michael Zanrosso | Radiation source device |
| NL1032714C2 (nl) * | 2006-10-20 | 2008-04-22 | Isodose Control Intellectual P | Transportkabel en broncapsule met veilige verbindingsconstructie voor het inwendig bestralen van patienten. |
| US8663210B2 (en) * | 2009-05-13 | 2014-03-04 | Novian Health, Inc. | Methods and apparatus for performing interstitial laser therapy and interstitial brachytherapy |
| JP2013515061A (ja) † | 2009-12-22 | 2013-05-02 | ダウ テクノロジー インベストメンツ リミティド ライアビリティー カンパニー | 混合リガンドヒドロホルミル化プロセスにおけるノルマル：イソアルデヒド比の制御 |
| US20110264220A1 (en) * | 2010-04-23 | 2011-10-27 | Warsaw Orthopedic, Inc. | Device and method for delivering radiation |
| US20120004493A1 (en) * | 2010-07-02 | 2012-01-05 | Hedger Troy S | System for delivering treatment agents |
| US10350431B2 (en) | 2011-04-28 | 2019-07-16 | Gt Medical Technologies, Inc. | Customizable radioactive carriers and loading system |
| EP2714196B1 (en) * | 2011-06-01 | 2016-09-21 | Nucletron Operations B.V. | Brachytherapy source assembly |
| US20130123912A1 (en) * | 2011-11-15 | 2013-05-16 | Boston Scientific Scimed, Inc. | Medical device with nosecone and nosecone tube extension |
| US9821174B1 (en) | 2015-02-06 | 2017-11-21 | Gammatile Llc | Radioactive implant planning system and placement guide system |
| US10888710B1 (en) | 2016-11-29 | 2021-01-12 | Gt Medical Technologies, Inc. | Transparent loading apparatus |
| US10580543B2 (en) * | 2018-05-01 | 2020-03-03 | Qsa Global, Inc. | Neutron sealed source |
| TWI757716B (zh) | 2019-04-15 | 2022-03-11 | 禾榮科技股份有限公司 | 微創型中子束產生裝置及微創型中子捕獲治療系統 |
| US12053644B2 (en) | 2021-12-30 | 2024-08-06 | Gt Medical Technologies, Inc. | Radiation shielding apparatus for implantable radioactive seeds |
Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2348714A1 (fr) | 1976-04-20 | 1977-11-18 | Cgr Mev | Appareil de curietherapie |
| US4112306A (en) | 1976-12-06 | 1978-09-05 | Varian Associates, Inc. | Neutron irradiation therapy machine |
| JPS5373892A (en) | 1976-12-11 | 1978-06-30 | Kenkichi Tsukamoto | Improved needle and attached ampule |
| US4197170A (en) | 1977-10-11 | 1980-04-08 | Monsanto Research Corporation | Radiation sources and process |
| US4510924A (en) | 1980-07-10 | 1985-04-16 | Yale-New Haven Hospital, Inc. | Brachytherapy devices and methods employing americium-241 |
| DE3442762A1 (de) | 1984-11-23 | 1986-06-26 | Anwer Dipl.-Ing. 8520 Erlangen Puthawala | Ferngesteuerte afterloading vorrichtung zur brachycurie-therapie von tumoren |
| US5322499A (en) | 1985-09-20 | 1994-06-21 | Liprie Sam F | Continuous sheated low dose radioactive core adapted for cutting into short sealed segments |
| US5141487A (en) | 1985-09-20 | 1992-08-25 | Liprie Sam F | Attachment of radioactive source and guidewire in a branchy therapy source wire |
| DE3534760C1 (de) | 1985-09-28 | 1987-05-07 | Bbc Reaktor Gmbh | Einrichtung zum Erzeugen thermischer Neutronen |
| DE3534686C1 (de) | 1985-09-28 | 1987-05-07 | Bbc Reaktor Gmbh | Einrichtung zum Durchstrahlen eines Objektes mit einer transportablen,thermische Neutronen erzeugenden Quelle |
| US4763642A (en) | 1986-04-07 | 1988-08-16 | Horowitz Bruce S | Intracavitational brachytherapy |
| US4819618A (en) | 1986-08-18 | 1989-04-11 | Liprie Sam F | Iridium/platinum implant, method of encapsulation, and method of implantation |
| USH669H (en) | 1986-12-08 | 1989-09-05 | The United States Of America As Represented By The United States Department Of Energy | Samarium-145 and its use as a radiation source |
| FR2609898B1 (fr) | 1987-01-28 | 1989-03-31 | Commissariat Energie Atomique | Dispositif d'entrainement et de positionnement d'un porte-sources dans un applicateur utilise en curietherapie |
| US4994013A (en) | 1988-07-28 | 1991-02-19 | Best Industries, Inc. | Pellet for a radioactive seed |
| US4891165A (en) | 1988-07-28 | 1990-01-02 | Best Industries, Inc. | Device and method for encapsulating radioactive materials |
| US5084002A (en) | 1988-08-04 | 1992-01-28 | Omnitron International, Inc. | Ultra-thin high dose iridium source for remote afterloader |
| US5183455A (en) | 1988-10-07 | 1993-02-02 | Omnitron International, Inc. | Apparatus for in situ radiotherapy |
| US5480382A (en) * | 1989-01-09 | 1996-01-02 | Pilot Cardiovascular Systems, Inc. | Steerable medical device |
| US4957476A (en) | 1989-01-09 | 1990-09-18 | University Of Pittsburgh | Afterloading radioactive spiral implanter |
| US4963128A (en) | 1989-03-21 | 1990-10-16 | University Of Virginia Alumni Patents Foundation | Chest tube and catheter grid for intrathoracic afterload radiotherapy |
| US5199939B1 (en) | 1990-02-23 | 1998-08-18 | Michael D Dake | Radioactive catheter |
| US5267960A (en) | 1990-03-19 | 1993-12-07 | Omnitron International Inc. | Tissue engaging catheter for a radioactive source wire |
| US5342283A (en) | 1990-08-13 | 1994-08-30 | Good Roger R | Endocurietherapy |
| US5092834A (en) | 1990-10-12 | 1992-03-03 | Omnitron International, Inc. | Apparatus and method for the remote handling of highly radioactive sources in the treatment of cancer |
| US5282781A (en) | 1990-10-25 | 1994-02-01 | Omnitron International Inc. | Source wire for localized radiation treatment of tumors |
| WO1992010932A1 (en) | 1990-12-17 | 1992-07-09 | Microwave Medical Systems, Inc. | Therapeutic probe for radiating microwave and nuclear radiation |
| US5531662A (en) | 1990-12-17 | 1996-07-02 | Microwave Medical Systems, Inc. | Dual mode microwave/ionizing probe |
| US5395300A (en) | 1991-06-07 | 1995-03-07 | Omnitron International, Inc. | High dosage radioactive source |
| WO1993008210A1 (en) | 1991-10-18 | 1993-04-29 | Beth Israel Hospital Association | Vascular permeability factor targeted compounds |
| US5317616A (en) | 1992-03-19 | 1994-05-31 | Wisconsin Alumni Research Foundation | Method and apparatus for radiation therapy |
| US5643171A (en) | 1993-05-04 | 1997-07-01 | Neocardia, Llc | Method and apparatus for uniform radiation treatment of vascular lumens |
| US5498227A (en) | 1993-09-15 | 1996-03-12 | Mawad; Michel E. | Retrievable, shielded radiotherapy implant |
| US5599796A (en) | 1993-12-02 | 1997-02-04 | Emory University | Treatment of urogenital cancer with boron neutron capture therapy |
| US5618266A (en) | 1994-03-31 | 1997-04-08 | Liprie; Samuel F. | Catheter for maneuvering radioactive source wire to site of treatment |
| US5857956A (en) | 1994-06-08 | 1999-01-12 | United States Surgical Corporation | Flexible source wire for localized internal irradiation of tissue |
| US5503614A (en) | 1994-06-08 | 1996-04-02 | Liprie; Samuel F. | Flexible source wire for radiation treatment of diseases |
| US5562594A (en) | 1994-06-10 | 1996-10-08 | Duke University | Shielded mini-applicator system for radioactive source treatment of cancer of the uterine cervix |
| EP0774929A4 (en) | 1994-07-22 | 2000-09-27 | Univ Washington | Methods for stereotactic implantation |
| US5626829A (en) | 1994-11-16 | 1997-05-06 | Pgk, Enterprises, Inc. | Method and apparatus for interstitial radiation of the prostate gland |
| US5616114A (en) | 1994-12-08 | 1997-04-01 | Neocardia, Llc. | Intravascular radiotherapy employing a liquid-suspended source |
| US5653683A (en) | 1995-02-28 | 1997-08-05 | D'andrea; Mark A. | Intracavitary catheter for use in therapeutic radiation procedures |
| US5851172A (en) | 1995-05-08 | 1998-12-22 | Omnitron International, Inc. | Afterloader with active force feedback |
| DE19526680A1 (de) | 1995-07-21 | 1997-01-23 | Huels Chemische Werke Ag | Flexible, anpaßbare Kunststoff-Körper mit Einzelkathetern oder äquidistant eingebetteten Kathetern oder Hülsen zur Einführung von Kathetern für die Strahlentherapie |
| US6019736A (en) * | 1995-11-06 | 2000-02-01 | Francisco J. Avellanet | Guidewire for catheter |
| US5833593A (en) | 1995-11-09 | 1998-11-10 | United States Surgical Corporation | Flexible source wire for localized internal irradiation of tissue |
| US5840008A (en) | 1995-11-13 | 1998-11-24 | Localmed, Inc. | Radiation emitting sleeve catheter and methods |
| US5713828A (en) | 1995-11-27 | 1998-02-03 | International Brachytherapy S.A | Hollow-tube brachytherapy device |
| US5800333A (en) | 1996-02-20 | 1998-09-01 | United States Surgical Corporation | Afterloader provided with remote control unit |
| NL1003528C2 (nl) * | 1996-07-05 | 1998-01-07 | Optische Ind Oede Oude Delftoe | Samenstel van een capsule voor brachytherapie en een leidraad. |
| US5860909A (en) | 1996-10-18 | 1999-01-19 | Mick Radio Nuclear Instruments, Inc. | Seed applicator for use in radiation therapy |
| US5782741A (en) * | 1996-11-12 | 1998-07-21 | Guidant Coropration | Two-stage treatment wire |
| US5882291A (en) | 1996-12-10 | 1999-03-16 | Neocardia, Llc | Device and method for controlling dose rate during intravascular radiotherapy |
| US5722985A (en) | 1996-12-27 | 1998-03-03 | Pettus; William G. | Instrument for tumor therapy |
| US6352500B1 (en) * | 1999-09-13 | 2002-03-05 | Isotron, Inc. | Neutron brachytherapy device and method |
-
1999
- 1999-09-13 US US09/395,324 patent/US6352500B1/en not_active Expired - Lifetime
-
2000
- 2000-09-13 CA CA002381996A patent/CA2381996A1/en not_active Abandoned
- 2000-09-13 EP EP00970454A patent/EP1218061B1/en not_active Expired - Lifetime
- 2000-09-13 NZ NZ518274A patent/NZ518274A/en unknown
- 2000-09-13 AT AT00970454T patent/ATE555826T1/de active
- 2000-09-13 WO PCT/US2000/025132 patent/WO2001019450A2/en not_active Ceased
- 2000-09-13 IL IL14863400A patent/IL148634A0/xx active IP Right Grant
- 2000-09-13 AU AU79833/00A patent/AU778456B2/en not_active Ceased
- 2000-09-13 JP JP2001523077A patent/JP4574925B2/ja not_active Expired - Fee Related
-
2001
- 2001-11-08 US US10/035,493 patent/US6770021B2/en not_active Expired - Fee Related
-
2002
- 2002-03-12 IL IL148634A patent/IL148634A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001019450A3 (en) | 2001-12-27 |
| IL148634A0 (en) | 2002-09-12 |
| JP2003509137A (ja) | 2003-03-11 |
| ATE555826T1 (de) | 2012-05-15 |
| EP1218061B1 (en) | 2012-05-02 |
| NZ518274A (en) | 2005-03-24 |
| EP1218061A2 (en) | 2002-07-03 |
| JP4574925B2 (ja) | 2010-11-04 |
| AU778456B2 (en) | 2004-12-09 |
| EP1218061A4 (en) | 2008-05-28 |
| WO2001019450A2 (en) | 2001-03-22 |
| AU7983300A (en) | 2001-04-17 |
| US20020058851A1 (en) | 2002-05-16 |
| IL148634A (en) | 2008-06-05 |
| US6770021B2 (en) | 2004-08-03 |
| US6352500B1 (en) | 2002-03-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US6352500B1 (en) | Neutron brachytherapy device and method | |
| US5575749A (en) | Ultra-thin high dose radioactive source wire | |
| EP1126900B1 (en) | Transmutable radiotherapy device and methods of making same | |
| AU731357B2 (en) | Combination radioactive and temperature self-regulating thermal seed implant for treating tumors | |
| US12246191B2 (en) | Diffusing alpha-emitter radiation therapy with enhanced beta treatment | |
| US6419621B1 (en) | Coiled brachytherapy device | |
| US6471630B1 (en) | Transmutable radiotherapy device | |
| US20080004483A1 (en) | Biodegradable seed placement device and method | |
| MXPA03000528A (es) | Simientes de braquiterapia de 103pd libre de vehiculo. | |
| US6400796B1 (en) | X-ray emitting sources and uses thereof | |
| AU2008200015A1 (en) | Carrier-free 103ZPd brachytherapy seeds |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |