CA2379661A1 - Systeme d'administration paracellulaire de medicament - Google Patents
Systeme d'administration paracellulaire de medicament Download PDFInfo
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- CA2379661A1 CA2379661A1 CA 2379661 CA2379661A CA2379661A1 CA 2379661 A1 CA2379661 A1 CA 2379661A1 CA 2379661 CA2379661 CA 2379661 CA 2379661 A CA2379661 A CA 2379661A CA 2379661 A1 CA2379661 A1 CA 2379661A1
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- claudin
- peptide
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- A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Engineering & Computer Science (AREA)
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- Wood Science & Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
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- Pathology (AREA)
- Diabetes (AREA)
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- Epidemiology (AREA)
- Plant Pathology (AREA)
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- Endocrinology (AREA)
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- Microbiology (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CA 2379661 CA2379661A1 (fr) | 2002-03-28 | 2002-03-28 | Systeme d'administration paracellulaire de medicament |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA 2379661 CA2379661A1 (fr) | 2002-03-28 | 2002-03-28 | Systeme d'administration paracellulaire de medicament |
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CA2379661A1 true CA2379661A1 (fr) | 2003-09-28 |
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Application Number | Title | Priority Date | Filing Date |
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CA 2379661 Abandoned CA2379661A1 (fr) | 2002-03-28 | 2002-03-28 | Systeme d'administration paracellulaire de medicament |
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Cited By (12)
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EP2322555A1 (fr) * | 2009-11-11 | 2011-05-18 | Ganymed Pharmaceuticals AG | Anticorps spécifiques pour claudin 6 (CLDN6) |
WO2011057788A1 (fr) * | 2009-11-11 | 2011-05-19 | Ganymed Pharmaceuticals Ag | Anticorps spécifiques pour la claudine 6 (cldn6) |
EP2241578A4 (fr) * | 2008-01-11 | 2012-09-12 | Univ Tokyo | Anticorps anti-cldn6 |
US8936785B2 (en) | 2006-07-10 | 2015-01-20 | ESBATech, an Alcon Biomedical Research Unit, LLC | scFv antibodies which pass epithelial and/or endothelial layers |
US9212228B2 (en) | 2005-11-24 | 2015-12-15 | Ganymed Pharmaceuticals Ag | Monoclonal antibodies against claudin-18 for treatment of cancer |
US9321842B2 (en) | 2011-05-13 | 2016-04-26 | Ganymed Pharmaceuticals Ag | Antibodies for treatment of cancer |
US9512232B2 (en) | 2012-05-09 | 2016-12-06 | Ganymed Pharmaceuticals Ag | Antibodies against Claudin 18.2 useful in cancer diagnosis |
US9718886B2 (en) | 2010-07-06 | 2017-08-01 | Ganymed Pharmaceuticals Ag | Cancer therapy using CLDN6 target-directed antibodies in vivo |
US9775785B2 (en) | 2004-05-18 | 2017-10-03 | Ganymed Pharmaceuticals Ag | Antibody to genetic products differentially expressed in tumors and the use thereof |
US9809815B2 (en) | 2009-02-20 | 2017-11-07 | Ganymed Pharmaceuticals Ag | Methods and compositions for diagnosis and treatment of cancer |
US10414824B2 (en) | 2002-11-22 | 2019-09-17 | Ganymed Pharmaceuticals Ag | Genetic products differentially expressed in tumors and the use thereof |
US10604568B2 (en) | 2013-07-31 | 2020-03-31 | BioN Tech AG | Diagnosis and therapy of cancer involving cancer stem cells |
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2002
- 2002-03-28 CA CA 2379661 patent/CA2379661A1/fr not_active Abandoned
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US10414824B2 (en) | 2002-11-22 | 2019-09-17 | Ganymed Pharmaceuticals Ag | Genetic products differentially expressed in tumors and the use thereof |
US9775785B2 (en) | 2004-05-18 | 2017-10-03 | Ganymed Pharmaceuticals Ag | Antibody to genetic products differentially expressed in tumors and the use thereof |
US11739139B2 (en) | 2005-11-24 | 2023-08-29 | Astellas Pharma Inc. | Monoclonal antibodies against Claudin-18 for treatment of cancer |
US10738108B2 (en) | 2005-11-24 | 2020-08-11 | Astellas Pharma Inc. | Monoclonal antibodies against claudin-18 for treatment of cancer |
US9212228B2 (en) | 2005-11-24 | 2015-12-15 | Ganymed Pharmaceuticals Ag | Monoclonal antibodies against claudin-18 for treatment of cancer |
US10174104B2 (en) | 2005-11-24 | 2019-01-08 | Ganymed Pharmaceuticals Gmbh | Monoclonal antibodies against claudin-18 for treatment of cancer |
US10017564B2 (en) | 2005-11-24 | 2018-07-10 | Ganymed Pharmaceuticals Gmbh | Monoclonal antibodies against claudin-18 for treatment of cancer |
US9751934B2 (en) | 2005-11-24 | 2017-09-05 | Ganymed Pharmaceuticals Ag | Monoclonal antibodies against claudin-18 for treatment of cancer |
US9499609B2 (en) | 2005-11-24 | 2016-11-22 | Ganymed Pharmaceuticals Ag | Monoclonal antibodies against claudin-18 for treatment of cancer |
EP3093026A1 (fr) | 2006-07-10 | 2016-11-16 | ESBATech, an Alcon Biomedical Research Unit LLC | Anticorps scfv traversant des couches endothéliales et/ou epithéliales |
US8936785B2 (en) | 2006-07-10 | 2015-01-20 | ESBATech, an Alcon Biomedical Research Unit, LLC | scFv antibodies which pass epithelial and/or endothelial layers |
EP3064512A3 (fr) * | 2008-01-11 | 2016-10-19 | The University of Tokyo | Anticorps contre cldn6 |
EP2241578A4 (fr) * | 2008-01-11 | 2012-09-12 | Univ Tokyo | Anticorps anti-cldn6 |
EP4282428A3 (fr) * | 2008-01-11 | 2024-03-20 | The University of Tokyo | Anticorps contre cldn6 |
US9274119B2 (en) | 2008-01-11 | 2016-03-01 | The University Of Tokyo | Anti-CLDN6 antibody |
EP2241578B1 (fr) | 2008-01-11 | 2016-04-20 | The University of Tokyo | Anticorps anti-cldn6 |
US9809815B2 (en) | 2009-02-20 | 2017-11-07 | Ganymed Pharmaceuticals Ag | Methods and compositions for diagnosis and treatment of cancer |
US11473085B2 (en) | 2009-02-20 | 2022-10-18 | Ganymed Pharmaceuticals Gmbh | Methods and compositions for diagnosis and treatment of cancer |
US9932401B2 (en) | 2009-11-11 | 2018-04-03 | Ganymed Pharmaceuticals Ag | Antibodies specific for claudin 6 (CLDN6) |
US9487584B2 (en) | 2009-11-11 | 2016-11-08 | Ganymed Pharmaceuticals Ag | Antibodies specific for claudin 6 (CLDN6) |
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WO2011057788A1 (fr) * | 2009-11-11 | 2011-05-19 | Ganymed Pharmaceuticals Ag | Anticorps spécifiques pour la claudine 6 (cldn6) |
US11858988B2 (en) | 2009-11-11 | 2024-01-02 | Ganymed Pharmaceuticals Gmbh | Antibodies specific for claudin 6 (CLDN6) |
CN105348389A (zh) * | 2009-11-11 | 2016-02-24 | 加尼梅德药物公司 | 密蛋白6(cldn6)特异性的抗体 |
US10745477B2 (en) | 2009-11-11 | 2020-08-18 | Ganymed Pharmaceuticals Gmbh | Antibodies specific for claudin 6 (CLDN6) |
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CN105348389B (zh) * | 2009-11-11 | 2019-12-20 | 加尼梅德药物公司 | 密蛋白6(cldn6)特异性的抗体 |
EP2322555A1 (fr) * | 2009-11-11 | 2011-05-18 | Ganymed Pharmaceuticals AG | Anticorps spécifiques pour claudin 6 (CLDN6) |
US9902778B2 (en) | 2010-07-06 | 2018-02-27 | Ganymed Pharmaceuticals Ag | Cancer therapy using CLDN6 target-directed antibodies in vivo |
US10844133B2 (en) | 2010-07-06 | 2020-11-24 | Ganymed Pharmaceuticals Gmbh | Cancer therapy using CLDN6 target-directed antibodies in vivo |
US9718886B2 (en) | 2010-07-06 | 2017-08-01 | Ganymed Pharmaceuticals Ag | Cancer therapy using CLDN6 target-directed antibodies in vivo |
US10233253B2 (en) | 2011-05-13 | 2019-03-19 | Ganymed Pharmaceuticals Ag | Antibodies for treatment of cancer expressing claudin 6 |
US10919974B2 (en) | 2011-05-13 | 2021-02-16 | Ganymed Pharmaceuticals Gmbh | Antibodies for treatment of cancer expressing claudin 6 |
US9321842B2 (en) | 2011-05-13 | 2016-04-26 | Ganymed Pharmaceuticals Ag | Antibodies for treatment of cancer |
US11859008B2 (en) | 2011-05-13 | 2024-01-02 | Ganymed Pharmaceuticals Gmbh | Antibodies for treatment of cancer expressing claudin 6 |
US10053512B2 (en) | 2012-05-09 | 2018-08-21 | Ganymed Pharmaceuticals Ag | Antibodies against claudin 18.2 useful in cancer diagnosis |
US9512232B2 (en) | 2012-05-09 | 2016-12-06 | Ganymed Pharmaceuticals Ag | Antibodies against Claudin 18.2 useful in cancer diagnosis |
US11976130B2 (en) | 2012-05-09 | 2024-05-07 | Astellas Pharma Inc. | Antibodies against claudin 18.2 useful in cancer diagnosis |
US10604568B2 (en) | 2013-07-31 | 2020-03-31 | BioN Tech AG | Diagnosis and therapy of cancer involving cancer stem cells |
US11795218B2 (en) | 2013-07-31 | 2023-10-24 | Biontech Ag | Diagnosis and therapy of cancer involving cancer stem cells |
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