CA2376926A1 - Vaccins - Google Patents
Vaccins Download PDFInfo
- Publication number
- CA2376926A1 CA2376926A1 CA002376926A CA2376926A CA2376926A1 CA 2376926 A1 CA2376926 A1 CA 2376926A1 CA 002376926 A CA002376926 A CA 002376926A CA 2376926 A CA2376926 A CA 2376926A CA 2376926 A1 CA2376926 A1 CA 2376926A1
- Authority
- CA
- Canada
- Prior art keywords
- vaccine
- cpg
- rts
- oligonucleotide
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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Classifications
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
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- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La présente invention concerne une formulation de vaccin destinée à prévenir ou à soulager les infections à Plasmodium chez les humains. Le vaccin de l'invention comprend un antigène de la malaria, en particulier une protéine qui comprend une partie de la protéine CS de P. falciparum fusionnée en phase via une séquence de liaison linéaire à l'extrémité N-terminale de HbsAg, et un oligonucléotide CpG immunostimulant. L'invention se rapporte également à des procédés de fabrication de la formulation de vaccin de l'invention. On peut également traiter les patients en leur administrant l'oligonucléotide CpG avant de leur administrer l'antigène de la malaria.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9915204.3 | 1999-06-29 | ||
| GBGB9915204.3A GB9915204D0 (en) | 1999-06-29 | 1999-06-29 | Vaccine |
| PCT/EP2000/005841 WO2001000231A2 (fr) | 1999-06-29 | 2000-06-23 | Vaccins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2376926A1 true CA2376926A1 (fr) | 2001-01-04 |
Family
ID=10856286
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002376926A Abandoned CA2376926A1 (fr) | 1999-06-29 | 2000-06-23 | Vaccins |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1198243A2 (fr) |
| AU (1) | AU5977700A (fr) |
| CA (1) | CA2376926A1 (fr) |
| GB (1) | GB9915204D0 (fr) |
| HK (1) | HK1047034A1 (fr) |
| WO (1) | WO2001000231A2 (fr) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| ES2628744T3 (es) | 1998-05-22 | 2017-08-03 | Ottawa Hospital Research Institute | Métodos y productos para inducir inmunidad en mucosas |
| GB9908885D0 (en) * | 1999-04-19 | 1999-06-16 | Smithkline Beecham Biolog | Vccine |
| US7129222B2 (en) | 2000-03-10 | 2006-10-31 | Dynavax Technologies Corporation | Immunomodulatory formulations and methods for use thereof |
| US20030129251A1 (en) | 2000-03-10 | 2003-07-10 | Gary Van Nest | Biodegradable immunomodulatory formulations and methods for use thereof |
| US7306806B2 (en) | 2001-01-26 | 2007-12-11 | United States Of America As Represented By The Secretary Of The Army | Recombinant P. falciparum merozoite protein-142 vaccine |
| AU2002343321A1 (en) * | 2001-01-26 | 2003-01-21 | Walter Reed Army Institute Of Research | Isolation and purification of plasmodium falciparum merozoite protein-142 |
| EP1414490A1 (fr) * | 2001-08-10 | 2004-05-06 | Dynavax Technologies Corporation | Preparations d'oligonucleotides immunomodulateurs et leurs procedes d'utilisation |
| CA2388049A1 (fr) | 2002-05-30 | 2003-11-30 | Immunotech S.A. | Oligonucleotides immunostimulateurs et utilisations connexes |
| JP2006505252A (ja) * | 2002-08-14 | 2006-02-16 | アヴィディス エスアー | 抗原およびアジュバントの多量体複合体 |
| JP4199988B2 (ja) * | 2002-11-14 | 2008-12-24 | 大日本印刷株式会社 | 化粧シート |
| AU2007293672B2 (en) | 2006-09-07 | 2013-06-27 | Glaxosmithkline Biologicals S.A. | Vaccine |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993010152A1 (fr) * | 1991-11-16 | 1993-05-27 | Smithkline Beecham Biologicals S.A. | Proteine hybride entre la proteine cs de plasmodium et l'antigene de surface du virus de l'hepatite b |
| ATE509102T1 (de) * | 1994-07-15 | 2011-05-15 | Univ Iowa Res Found | Immunomodulatorische oligonukleotide |
| GB9616351D0 (en) * | 1996-08-02 | 1996-09-11 | Smithkline Beecham Biolog | Vaccine composition |
| EP1039935A4 (fr) * | 1997-02-28 | 2005-04-27 | Univ Iowa Res Found | UTILISATION D'ACIDES NUCLEIQUES CONTENANT DES DINUCLEOTIDES CpG NON METHYLES DANS LE TRAITEMENT DES TROUBLES ASSOCIES AUX LIPOPOLYSACCHARIDES |
| EP1005368B1 (fr) * | 1997-03-10 | 2009-09-02 | Ottawa Hospital Research Institute | Utilisation d'acides nucléiques contenat un dinucléotide CpG non-methylé combiné avec de l'aluminium en tant qu'adjuvants |
| ES2201551T3 (es) * | 1997-09-05 | 2004-03-16 | Glaxosmithkline Biologicals S.A. | Emulsiones de aceite en agua que contienen saponinas. |
| AU750587B2 (en) * | 1998-10-16 | 2002-07-25 | Smithkline Beecham Biologicals (Sa) | Adjuvant systems and vaccines |
| HU229255B1 (en) * | 1999-04-19 | 2013-10-28 | Smithkline Beecham Biolog | Vaccines |
-
1999
- 1999-06-29 GB GBGB9915204.3A patent/GB9915204D0/en not_active Ceased
-
2000
- 2000-06-23 WO PCT/EP2000/005841 patent/WO2001000231A2/fr active Application Filing
- 2000-06-23 CA CA002376926A patent/CA2376926A1/fr not_active Abandoned
- 2000-06-23 EP EP00945810A patent/EP1198243A2/fr not_active Ceased
- 2000-06-23 AU AU59777/00A patent/AU5977700A/en not_active Abandoned
-
2002
- 2002-09-26 HK HK02107137.7A patent/HK1047034A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HK1047034A1 (zh) | 2003-02-07 |
| GB9915204D0 (en) | 1999-09-01 |
| WO2001000231A2 (fr) | 2001-01-04 |
| AU5977700A (en) | 2001-01-31 |
| WO2001000231A3 (fr) | 2001-07-05 |
| EP1198243A2 (fr) | 2002-04-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |