CA2370276C - Needleless syringe - Google Patents
Needleless syringe Download PDFInfo
- Publication number
- CA2370276C CA2370276C CA2370276A CA2370276A CA2370276C CA 2370276 C CA2370276 C CA 2370276C CA 2370276 A CA2370276 A CA 2370276A CA 2370276 A CA2370276 A CA 2370276A CA 2370276 C CA2370276 C CA 2370276C
- Authority
- CA
- Canada
- Prior art keywords
- particles
- gas
- duct
- gas discharge
- lumen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000002245 particle Substances 0.000 claims abstract description 122
- 238000011144 upstream manufacturing Methods 0.000 claims abstract description 20
- 241000251539 Vertebrata <Metazoa> Species 0.000 claims abstract description 7
- 239000012528 membrane Substances 0.000 claims description 23
- 239000002775 capsule Substances 0.000 claims description 9
- 238000010276 construction Methods 0.000 claims description 6
- 230000000694 effects Effects 0.000 claims description 4
- 230000037452 priming Effects 0.000 claims description 3
- 125000006850 spacer group Chemical group 0.000 claims description 3
- 239000007789 gas Substances 0.000 description 93
- 210000004379 membrane Anatomy 0.000 description 20
- 210000001519 tissue Anatomy 0.000 description 16
- 239000003814 drug Substances 0.000 description 14
- 229940079593 drug Drugs 0.000 description 10
- 230000008901 benefit Effects 0.000 description 9
- 230000036407 pain Effects 0.000 description 8
- 210000003491 skin Anatomy 0.000 description 8
- 230000009172 bursting Effects 0.000 description 6
- 230000037317 transdermal delivery Effects 0.000 description 6
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 5
- 238000009826 distribution Methods 0.000 description 5
- 229960004194 lidocaine Drugs 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 229920000642 polymer Polymers 0.000 description 5
- 230000001133 acceleration Effects 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 230000035939 shock Effects 0.000 description 4
- 206010028980 Neoplasm Diseases 0.000 description 3
- 239000000853 adhesive Substances 0.000 description 3
- 230000001070 adhesive effect Effects 0.000 description 3
- 229960000074 biopharmaceutical Drugs 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 238000005336 cracking Methods 0.000 description 3
- 238000013461 design Methods 0.000 description 3
- 238000007599 discharging Methods 0.000 description 3
- 229910052734 helium Inorganic materials 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 238000007789 sealing Methods 0.000 description 3
- 206010002091 Anaesthesia Diseases 0.000 description 2
- 238000001949 anaesthesia Methods 0.000 description 2
- 230000037005 anaesthesia Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 230000030279 gene silencing Effects 0.000 description 2
- 238000001415 gene therapy Methods 0.000 description 2
- 239000001307 helium Substances 0.000 description 2
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 210000002751 lymph Anatomy 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 239000003566 sealing material Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- GMVPRGQOIOIIMI-UHFFFAOYSA-N (8R,11R,12R,13E,15S)-11,15-Dihydroxy-9-oxo-13-prostenoic acid Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CCCCCCC(O)=O GMVPRGQOIOIIMI-UHFFFAOYSA-N 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 206010070840 Gastrointestinal tract irritation Diseases 0.000 description 1
- 206010069803 Injury associated with device Diseases 0.000 description 1
- 208000012266 Needlestick injury Diseases 0.000 description 1
- 206010043528 Throat tightness Diseases 0.000 description 1
- 230000009102 absorption Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000005534 acoustic noise Effects 0.000 description 1
- 229960000711 alprostadil Drugs 0.000 description 1
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 230000001856 erectile effect Effects 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 238000001476 gene delivery Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000013618 particulate matter Substances 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 210000003899 penis Anatomy 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- GMVPRGQOIOIIMI-DWKJAMRDSA-N prostaglandin E1 Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O GMVPRGQOIOIIMI-DWKJAMRDSA-N 0.000 description 1
- 238000002271 resection Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 230000003584 silencer Effects 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 239000012798 spherical particle Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 235000019640 taste Nutrition 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 229940043263 traditional drug Drugs 0.000 description 1
- 238000013271 transdermal drug delivery Methods 0.000 description 1
- 238000009966 trimming Methods 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
- A61M5/3015—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules for injecting a dose of particles in form of powdered drug, e.g. mounted on a rupturable membrane and accelerated by a gaseous shock wave or supersonic gas flow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M5/2053—Media being expelled from injector by pressurised fluid or vacuum
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Saccharide Compounds (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29332099A | 1999-04-16 | 1999-04-16 | |
| US09/293,320 | 1999-04-16 | ||
| PCT/GB2000/001421 WO2000062846A1 (en) | 1999-04-16 | 2000-04-14 | Needleless syringe |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2370276A1 CA2370276A1 (en) | 2000-10-26 |
| CA2370276C true CA2370276C (en) | 2010-01-26 |
Family
ID=23128607
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2370276A Expired - Fee Related CA2370276C (en) | 1999-04-16 | 2000-04-14 | Needleless syringe |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1171181B1 (enExample) |
| JP (1) | JP2003529392A (enExample) |
| KR (1) | KR100702653B1 (enExample) |
| AT (1) | ATE251922T1 (enExample) |
| AU (1) | AU765843B2 (enExample) |
| BR (1) | BR0009790B1 (enExample) |
| CA (1) | CA2370276C (enExample) |
| DE (1) | DE60005938T2 (enExample) |
| ES (1) | ES2208322T3 (enExample) |
| IL (2) | IL145668A0 (enExample) |
| MX (1) | MXPA01010470A (enExample) |
| NZ (1) | NZ514684A (enExample) |
| WO (1) | WO2000062846A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8221347B2 (en) | 2004-12-01 | 2012-07-17 | Acushot, Inc. | Needle-free injector |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2802102B1 (fr) * | 1999-12-08 | 2002-07-12 | Poudres & Explosifs Ste Nale | Seringue sans aiguille munie d'un tube d'ejection a section constante |
| CA2324045A1 (fr) * | 2000-10-20 | 2002-04-20 | Universite De Sherbrooke | Seringue sans aiguille pour l'injection sous-cutanee de poudres medicamenteuses |
| GB0118266D0 (en) | 2001-07-26 | 2001-09-19 | Powderject Res Ltd | Silencing device and method for needleless syringe |
| US8061006B2 (en) | 2001-07-26 | 2011-11-22 | Powderject Research Limited | Particle cassette, method and kit therefor |
| USD519633S1 (en) | 2003-11-12 | 2006-04-25 | Powderject Research Limited | Syringe |
| CA2629300C (en) * | 2005-11-17 | 2014-07-08 | Zogenix, Inc. | Delivery of viscous formulations by needle-free injection |
| DE102008063518A1 (de) | 2008-12-18 | 2010-07-01 | Lts Lohmann Therapie-Systeme Ag | Pumpfähiger Einmalinjektor mit einem biegeelastischen Gehäuse |
| DE102008063517A1 (de) | 2008-12-18 | 2010-07-01 | Lts Lohmann Therapie-Systeme Ag | Einmalinjektor mit einem biegeelastischen Gehäuse II |
| DE102008063519A1 (de) | 2008-12-18 | 2010-07-01 | Lts Lohmann Therapie-Systeme Ag | Einmalinjektor mit einem biegeelastischen Metallgehäuse |
| KR101097763B1 (ko) | 2009-09-22 | 2011-12-23 | 백우인 | 일회용 주사기 |
| US8486002B2 (en) * | 2011-04-19 | 2013-07-16 | Palo Alto Research Center Incorporated | Drug delivery devices and methods with collimated gas stream and release-activatable tape |
| US8388569B2 (en) * | 2011-04-19 | 2013-03-05 | Xerox Corporation | Delivery devices and methods with collimated gas stream and particle source |
| US8430839B2 (en) * | 2011-04-19 | 2013-04-30 | Palo Alto Research Center Incorporated | Drug delivery devices and methods with collimated gas stream and drug reservoir |
| WO2020086002A1 (en) * | 2018-10-26 | 2020-04-30 | Singapore Health Services Pte Ltd | Device and method for ophthalmic extraction and injection |
| CN115120854B (zh) * | 2022-07-04 | 2023-10-13 | 奥格生物技术（六安）有限公司 | 前列腺自然直接给药装置 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2645223A (en) * | 1951-02-17 | 1953-07-14 | Becton Dickinson Co | Injection device |
| JPH0284962A (ja) * | 1988-06-14 | 1990-03-26 | Vci Corp | 負圧圧着無針注射器 |
| TW404844B (en) * | 1993-04-08 | 2000-09-11 | Oxford Biosciences Ltd | Needleless syringe |
| JP3853360B2 (ja) * | 1994-10-24 | 2006-12-06 | パウダージェクト リサーチ リミテッド | 粒子供給装置 |
| GB9426379D0 (en) * | 1994-12-23 | 1995-03-01 | Oxford Biosciences Ltd | Particle delivery |
| US5829428A (en) * | 1996-05-29 | 1998-11-03 | Alliance Pharmaceutical Corp. | Methods and apparatus for reducing the loss of respiratory promoters |
| EP0888791A1 (en) * | 1997-07-04 | 1999-01-07 | PowderJect Research Limited | Syringe and drug capsule therefor |
-
2000
- 2000-04-14 JP JP2000611982A patent/JP2003529392A/ja active Pending
- 2000-04-14 WO PCT/GB2000/001421 patent/WO2000062846A1/en not_active Ceased
- 2000-04-14 IL IL14566800A patent/IL145668A0/xx active IP Right Grant
- 2000-04-14 CA CA2370276A patent/CA2370276C/en not_active Expired - Fee Related
- 2000-04-14 KR KR1020017013203A patent/KR100702653B1/ko not_active Expired - Fee Related
- 2000-04-14 MX MXPA01010470A patent/MXPA01010470A/es active IP Right Grant
- 2000-04-14 AU AU45790/00A patent/AU765843B2/en not_active Ceased
- 2000-04-14 EP EP00927382A patent/EP1171181B1/en not_active Expired - Lifetime
- 2000-04-14 DE DE60005938T patent/DE60005938T2/de not_active Expired - Lifetime
- 2000-04-14 BR BRPI0009790-0A patent/BR0009790B1/pt not_active IP Right Cessation
- 2000-04-14 AT AT00927382T patent/ATE251922T1/de not_active IP Right Cessation
- 2000-04-14 NZ NZ514684A patent/NZ514684A/xx not_active IP Right Cessation
- 2000-04-14 ES ES00927382T patent/ES2208322T3/es not_active Expired - Lifetime
-
2001
- 2001-09-25 IL IL145668A patent/IL145668A/en not_active IP Right Cessation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8221347B2 (en) | 2004-12-01 | 2012-07-17 | Acushot, Inc. | Needle-free injector |
Also Published As
| Publication number | Publication date |
|---|---|
| KR100702653B1 (ko) | 2007-04-02 |
| IL145668A (en) | 2007-06-03 |
| WO2000062846A1 (en) | 2000-10-26 |
| BR0009790B1 (pt) | 2008-11-18 |
| BR0009790A (pt) | 2002-01-08 |
| EP1171181A1 (en) | 2002-01-16 |
| DE60005938T2 (de) | 2004-07-29 |
| MXPA01010470A (es) | 2004-04-05 |
| CA2370276A1 (en) | 2000-10-26 |
| ES2208322T3 (es) | 2004-06-16 |
| DE60005938D1 (de) | 2003-11-20 |
| KR20020008835A (ko) | 2002-01-31 |
| NZ514684A (en) | 2003-04-29 |
| EP1171181B1 (en) | 2003-10-15 |
| JP2003529392A (ja) | 2003-10-07 |
| IL145668A0 (en) | 2002-06-30 |
| AU4579000A (en) | 2000-11-02 |
| ATE251922T1 (de) | 2003-11-15 |
| AU765843B2 (en) | 2003-10-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20140415 |