CA2369969A1 - Procede d'identification d'agents toxiques au moyen d'une expression genetique differentielle - Google Patents

Procede d'identification d'agents toxiques au moyen d'une expression genetique differentielle Download PDF

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Publication number
CA2369969A1
CA2369969A1 CA002369969A CA2369969A CA2369969A1 CA 2369969 A1 CA2369969 A1 CA 2369969A1 CA 002369969 A CA002369969 A CA 002369969A CA 2369969 A CA2369969 A CA 2369969A CA 2369969 A1 CA2369969 A1 CA 2369969A1
Authority
CA
Canada
Prior art keywords
hepatox
nucleic acid
expression
cell population
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002369969A
Other languages
English (en)
Inventor
Bonnie E. Gould-Rothberg
Vincent A. Dipippo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CuraGen Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2369969A1 publication Critical patent/CA2369969A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne des procédés d'identification d'agents toxiques, tels que des agents hépatotoxiques, au moyen d'une expression génétique différentielle. L'invention concerne également des nouvelles séquences d'acide nucléique dont l'expression est régulée de manière différentielle par de la troglitazone.
CA002369969A 1999-04-15 2000-04-14 Procede d'identification d'agents toxiques au moyen d'une expression genetique differentielle Abandoned CA2369969A1 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US12976399P 1999-04-15 1999-04-15
US60/129,763 1999-04-15
US15692499P 1999-09-28 1999-09-28
US60/156,924 1999-09-28
US54858900A 2000-04-13 2000-04-13
US09/548,589 2000-04-13
PCT/US2000/010076 WO2000063435A2 (fr) 1999-04-15 2000-04-14 Procede d'identification d'agents toxiques au moyen d'une expression genetique differentielle

Publications (1)

Publication Number Publication Date
CA2369969A1 true CA2369969A1 (fr) 2000-10-26

Family

ID=27383925

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002369969A Abandoned CA2369969A1 (fr) 1999-04-15 2000-04-14 Procede d'identification d'agents toxiques au moyen d'une expression genetique differentielle

Country Status (4)

Country Link
EP (1) EP1169481A1 (fr)
JP (1) JP2003513613A (fr)
CA (1) CA2369969A1 (fr)
WO (1) WO2000063435A2 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4652600A (en) * 1999-04-23 2000-11-10 Curagen Corporation Method of identifying ligands for the peroxisome proliferator activated receptorgamma using differential gene expression
US6852845B1 (en) 1999-11-22 2005-02-08 Curagen Corporation Method of identifying toxic agents using NSAID-induced differential gene expression in liver
CA2447357A1 (fr) 2001-05-22 2002-11-28 Gene Logic, Inc. Modelisation en toxicologie moleculaire
US7447594B2 (en) 2001-07-10 2008-11-04 Ocimum Biosolutions, Inc. Molecular cardiotoxicology modeling
US7469185B2 (en) 2002-02-04 2008-12-23 Ocimum Biosolutions, Inc. Primary rat hepatocyte toxicity modeling
US7396645B1 (en) 2002-12-17 2008-07-08 Entelos, Inc. Cholestasis signature
US7778782B1 (en) 2002-12-17 2010-08-17 Entelos, Inc. Peroxisome proliferation activated receptor alpha (PPARα) signatures
US7519519B1 (en) 2002-12-20 2009-04-14 Entelos, Inc. Signature projection score
US7422854B1 (en) 2002-12-20 2008-09-09 Entelos, Inc. Cholesterol reduction signature
JP2007501617A (ja) * 2003-08-07 2007-02-01 ジーン ロジック インコーポレイテッド 初代ラット肝細胞毒性モデリング
US7348144B2 (en) * 2003-08-13 2008-03-25 Agilent Technologies, Inc. Methods and system for multi-drug treatment discovery
US7795390B2 (en) 2005-06-24 2010-09-14 Teijin Pharma Limited Biological substance nesfatin and its related substances and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997013877A1 (fr) * 1995-10-12 1997-04-17 Lynx Therapeutics, Inc. Mesure de profils d'expression genique pour evaluer la toxicite
US5928888A (en) * 1996-09-26 1999-07-27 Aurora Biosciences Corporation Methods and compositions for sensitive and rapid, functional identification of genomic polynucleotides and secondary screening capabilities
CA2377768A1 (fr) * 1999-07-02 2001-01-11 Curagen Corporation Identification d'agents toxiques au moyen d'une l'expression genique differentielle
WO2001032928A2 (fr) * 1999-11-05 2001-05-10 Phase-1 Molecular Toxicology Methodes permettant de determiner une hypersensibilite a un agent
AU2001227900A1 (en) * 2000-01-14 2001-07-24 Incyte Genomics, Inc. Drug metabolizing enzymes
US20020110808A1 (en) * 2000-01-21 2002-08-15 Reidhaar-Olson John F. Toxicant-induced differential gene expression

Also Published As

Publication number Publication date
WO2000063435A3 (fr) 2002-09-12
WO2000063435A8 (fr) 2001-05-10
JP2003513613A (ja) 2003-04-15
WO2000063435A2 (fr) 2000-10-26
EP1169481A1 (fr) 2002-01-09

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Legal Events

Date Code Title Description
FZDE Discontinued