CA2367590A1 - Induction in vitro de cellules t specifiques a un antigene a l'aide d'immunogenes derives de cellules dendritiques-cellules tumorales ou de cellules dendritiques-cellules virales - Google Patents
Induction in vitro de cellules t specifiques a un antigene a l'aide d'immunogenes derives de cellules dendritiques-cellules tumorales ou de cellules dendritiques-cellules virales Download PDFInfo
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- CA2367590A1 CA2367590A1 CA002367590A CA2367590A CA2367590A1 CA 2367590 A1 CA2367590 A1 CA 2367590A1 CA 002367590 A CA002367590 A CA 002367590A CA 2367590 A CA2367590 A CA 2367590A CA 2367590 A1 CA2367590 A1 CA 2367590A1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/46449—Melanoma antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464499—Undefined tumor antigens, e.g. tumor lysate or antigens targeted by cells isolated from tumor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- C—CHEMISTRY; METALLURGY
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/55—Lung
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/57—Skin; melanoma
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/30—Coculture with; Conditioned medium produced by tumour cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/99—Coculture with; Conditioned medium produced by genetically modified cells
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Hematology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Cette invention concerne des cellules T spécifiques à un antigène, lesquelles sont obtenues en cultivant des cellules T dans des formulations qui comprennent des combinaisons de cellules dendritiques et de cellules soit tumorales, soit infectées par un virus. Ces formulations comprennent de manière générale un hybridome d'au moins une cellule dendritique fusionnée à au moins une cellule qui est soit tumorale, soit infectée par un virus, ou des co-cultures de cellules dendritiques et de cellules soit tumorales, soit infectées par un virus. Les cellules T ainsi obtenues peuvent être utilisées dans des procédés d'immunothérapie par le transfert adoptif chez le patient de cellules T spécifiques à un antigène et autologues, ceci à l'aide de techniques bien établies. Ces cellules peuvent être utilisées comme agents permettant d'identifier des antigènes de tumeurs, et d'établir des modèles animaux.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28267999A | 1999-03-31 | 1999-03-31 | |
| US09/282,679 | 1999-03-31 | ||
| PCT/US2000/008472 WO2000057705A1 (fr) | 1999-03-31 | 2000-03-30 | Induction in vitro de cellules t specifiques a un antigene a l'aide d'immunogenes derives de cellules dendritiques-cellules tumorales ou de cellules dendritiques-cellules virales |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2367590A1 true CA2367590A1 (fr) | 2000-10-05 |
Family
ID=23082644
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002367590A Abandoned CA2367590A1 (fr) | 1999-03-31 | 2000-03-30 | Induction in vitro de cellules t specifiques a un antigene a l'aide d'immunogenes derives de cellules dendritiques-cellules tumorales ou de cellules dendritiques-cellules virales |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1168924A4 (fr) |
| JP (1) | JP2002539805A (fr) |
| CN (1) | CN1353575A (fr) |
| AU (1) | AU4183100A (fr) |
| CA (1) | CA2367590A1 (fr) |
| WO (1) | WO2000057705A1 (fr) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050169898A1 (en) | 1997-04-15 | 2005-08-04 | Jianlin Gong | Cell fusions and methods of making and using the same |
| WO2001059073A2 (fr) * | 2000-02-11 | 2001-08-16 | Dana-Farber Cancer Institute, Inc. | Lymphocytes t cytotoxiques actives par des hybrides de cellules dendritiques |
| DE69839215T2 (de) | 1997-04-15 | 2009-03-19 | Dana-Farber Cancer Institute, Inc., Boston | Dendritische zellhybride |
| WO2001029193A2 (fr) * | 1999-10-22 | 2001-04-26 | Peter Leskovar | Constructions cellulaires adaptees a l'immunotherapie, leur production et leur utilisation |
| DE10164819A1 (de) * | 2001-11-20 | 2005-05-19 | Deml, Ludwig, Dr. | Verfahren zur Identifizierung von Zielepitopen der T-Zell-vermittelten Immunantwort und zum Nachweis Epitop-spezifischer T-Zellen |
| SI2511301T1 (en) | 2006-08-04 | 2018-05-31 | MedImmune Limited, | Human antibodies to ERBB 2 |
| DE102010037622B4 (de) * | 2010-09-17 | 2012-07-12 | Lophius Biosciences Gmbh | Verfahren zum Nachweis, Differenzieren und Quantifizieren von T-Zellpopulationen mittels der Reverse Transkription quantitativen Real-Time PCR (RT-qPCR) Technologie |
| EP2606897A1 (fr) | 2011-12-22 | 2013-06-26 | Laboratorios Del. Dr. Esteve, S.A. | Procédés et compositions pour le traitement des maladies causées par les virus enveloppés |
| CN102827826B (zh) * | 2012-09-11 | 2017-07-04 | 赵永祥 | 一种诱导树突状细胞与肿瘤细胞融合的方法 |
| WO2016145578A1 (fr) | 2015-03-13 | 2016-09-22 | Syz Cell Therapy Co. | Procédés de traitement du cancer au moyen de lymphocytes t activés |
| CN104830793A (zh) * | 2015-05-05 | 2015-08-12 | 杨光华 | 基于lmp-1抗原的dc细胞、靶向性免疫细胞群及其制备方法和用途 |
| WO2016183037A1 (fr) | 2015-05-08 | 2016-11-17 | Wilson Wolf Manufacturing | Procédés de culture améliorés et dispositifs de test |
| EP3316897A4 (fr) | 2015-07-02 | 2019-03-13 | Primevax Immuno-Oncology, Inc. | Compositions et procédés pour polythérapie utilisant le virus de la dengue et des cellules dendritiques |
| CA2999881A1 (fr) | 2015-09-26 | 2017-03-30 | PrimeVax Immuno-Oncology, Inc. | Compositions et procedes pour produire des cellules dendritiques |
| CN105532575A (zh) * | 2016-01-14 | 2016-05-04 | 中国科学院昆明动物研究所 | 一种单纯疱疹病毒感染树鼩动物模型的构建、评估方法及其应用 |
| WO2018093907A1 (fr) | 2016-11-16 | 2018-05-24 | PrimeVax Immuno-Oncology, Inc. | Immunothérapies d'association pour le traitement du cancer |
| WO2019183924A1 (fr) | 2018-03-30 | 2019-10-03 | Syz Cell Therapy Co. | Procédés améliorés de thérapie cellulaire spécifique à l'antigène |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| DE69634750T2 (de) * | 1995-03-31 | 2006-02-23 | Université Libre de Bruxelles | DENDRITENZELLEN/TUMORZELLEN Hybirde ZUR INDUKTION EINER ANTI-TUMOR ANTWORT |
| DE69839215T2 (de) * | 1997-04-15 | 2009-03-19 | Dana-Farber Cancer Institute, Inc., Boston | Dendritische zellhybride |
| JP2002500872A (ja) * | 1998-01-26 | 2002-01-15 | ジェンザイム・コーポレーション | 免疫エフェクター細胞ハイブリッド |
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- 2000-03-30 WO PCT/US2000/008472 patent/WO2000057705A1/fr not_active Application Discontinuation
- 2000-03-30 CN CN00808298A patent/CN1353575A/zh active Pending
- 2000-03-30 EP EP00921528A patent/EP1168924A4/fr not_active Withdrawn
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| AU4183100A (en) | 2000-10-16 |
| WO2000057705A1 (fr) | 2000-10-05 |
| CN1353575A (zh) | 2002-06-12 |
| JP2002539805A (ja) | 2002-11-26 |
| EP1168924A4 (fr) | 2002-09-04 |
| EP1168924A1 (fr) | 2002-01-09 |
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