CA2365405A1

CA2365405A1 - Human tumor necrosis factor receptor-like 2

Human tumor necrosis factor receptor-like 2 Download PDF

Info

Publication number: CA2365405A1
Authority: CA; Canada
Prior art keywords: seq; amino acid; polypeptides; sequence; antibody
Prior art date: 1999-03-22
Legal status : Abandoned

Application number

CA002365405A

Other languages

English (en)

French (fr)

Inventor

Jian Ni

Craig A. Rosen

Reiner L. Gentz

Current Assignee

Human Genome Sciences Inc

Original Assignee

Individual

Priority date

1999-03-22

Filing date

2000-03-22

Publication date

2000-09-28

2000-03-22 Application filed by Individual filed Critical Individual

2000-09-28 Publication of CA2365405A1 publication Critical patent/CA2365405A1/en

Status Abandoned legal-status Critical Current

Links

101000648507 Homo sapiens Tumor necrosis factor receptor superfamily member 14 Proteins 0.000 title abstract description 3
108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 485
102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 464
229920001184 polypeptide Polymers 0.000 claims abstract description 444
238000000034 method Methods 0.000 claims abstract description 204
108060008682 Tumor Necrosis Factor Proteins 0.000 claims abstract description 32
102000003390 tumor necrosis factor Human genes 0.000 claims abstract description 5
108090000623 proteins and genes Proteins 0.000 claims description 240
102000004169 proteins and genes Human genes 0.000 claims description 194
150000001413 amino acids Chemical class 0.000 claims description 105
239000000427 antigen Substances 0.000 claims description 51
108091007433 antigens Proteins 0.000 claims description 51
102000036639 antigens Human genes 0.000 claims description 51
239000003814 drug Substances 0.000 claims description 34
229940124597 therapeutic agent Drugs 0.000 claims description 28
206010028980 Neoplasm Diseases 0.000 claims description 20
239000000203 mixture Substances 0.000 claims description 18
201000011510 cancer Diseases 0.000 claims description 15
210000003719 b-lymphocyte Anatomy 0.000 claims description 14
238000001727 in vivo Methods 0.000 claims description 12
102000004127 Cytokines Human genes 0.000 claims description 10
108090000695 Cytokines Proteins 0.000 claims description 10
239000002256 antimetabolite Substances 0.000 claims description 8
239000003795 chemical substances by application Substances 0.000 claims description 8
238000011282 treatment Methods 0.000 claims description 8
AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims description 6
206010061598 Immunodeficiency Diseases 0.000 claims description 6
208000029462 Immunodeficiency disease Diseases 0.000 claims description 6
RJURFGZVJUQBHK-UHFFFAOYSA-N actinomycin D Natural products CC1OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C2CCCN2C(=O)C(C(C)C)NC(=O)C1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)NC4C(=O)NC(C(N5CCCC5C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-UHFFFAOYSA-N 0.000 claims description 6
229940127089 cytotoxic agent Drugs 0.000 claims description 6
230000007813 immunodeficiency Effects 0.000 claims description 6
NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 claims description 5
239000002246 antineoplastic agent Substances 0.000 claims description 5
STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 claims description 4
108010092160 Dactinomycin Proteins 0.000 claims description 4
108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 4
102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 4
239000003242 anti bacterial agent Substances 0.000 claims description 4
206010003246 arthritis Diseases 0.000 claims description 4
STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 claims description 4
206010061218 Inflammation Diseases 0.000 claims description 3
FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims description 3
RJURFGZVJUQBHK-IIXSONLDSA-N actinomycin D Chemical compound C[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H](C(C)C)NC(=O)[C@H]1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)N[C@@H]4C(=O)N[C@@H](C(N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-IIXSONLDSA-N 0.000 claims description 3
230000000340 anti-metabolite Effects 0.000 claims description 3
229940100197 antimetabolite Drugs 0.000 claims description 3
229960000640 dactinomycin Drugs 0.000 claims description 3
229960000975 daunorubicin Drugs 0.000 claims description 3
229960004679 doxorubicin Drugs 0.000 claims description 3
239000003937 drug carrier Substances 0.000 claims description 3
230000004054 inflammatory process Effects 0.000 claims description 3
210000000265 leukocyte Anatomy 0.000 claims description 3
229960000485 methotrexate Drugs 0.000 claims description 3
229960004857 mitomycin Drugs 0.000 claims description 3
230000004044 response Effects 0.000 claims description 3
108010006654 Bleomycin Proteins 0.000 claims description 2
229960001561 bleomycin Drugs 0.000 claims description 2
OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 claims description 2
230000002708 enhancing effect Effects 0.000 claims description 2
239000003018 immunosuppressive agent Substances 0.000 claims 6
229940125721 immunosuppressive agent Drugs 0.000 claims 6
239000003430 antimalarial agent Substances 0.000 claims 3
230000003115 biocidal effect Effects 0.000 claims 3
239000002981 blocking agent Substances 0.000 claims 3
208000003950 B-cell lymphoma Diseases 0.000 claims 2
229940121363 anti-inflammatory agent Drugs 0.000 claims 2
239000002260 anti-inflammatory agent Substances 0.000 claims 2
239000000546 pharmaceutical excipient Substances 0.000 claims 2
WHTVZRBIWZFKQO-AWEZNQCLSA-N (S)-chloroquine Chemical compound ClC1=CC=C2C(N[C@@H](C)CCCN(CC)CC)=CC=NC2=C1 WHTVZRBIWZFKQO-AWEZNQCLSA-N 0.000 claims 1
IDINUJSAMVOPCM-UHFFFAOYSA-N 15-Deoxyspergualin Natural products NCCCNCCCCNC(=O)C(O)NC(=O)CCCCCCN=C(N)N IDINUJSAMVOPCM-UHFFFAOYSA-N 0.000 claims 1
CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 1
PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 1
108010036949 Cyclosporine Proteins 0.000 claims 1
102000018233 Fibroblast Growth Factor Human genes 0.000 claims 1
108050007372 Fibroblast Growth Factor Proteins 0.000 claims 1
230000002491 angiogenic effect Effects 0.000 claims 1
229960002170 azathioprine Drugs 0.000 claims 1
LMEKQMALGUDUQG-UHFFFAOYSA-N azathioprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC=NC2=C1NC=N2 LMEKQMALGUDUQG-UHFFFAOYSA-N 0.000 claims 1
229960003677 chloroquine Drugs 0.000 claims 1
WHTVZRBIWZFKQO-UHFFFAOYSA-N chloroquine Natural products ClC1=CC=C2C(NC(C)CCCN(CC)CC)=CC=NC2=C1 WHTVZRBIWZFKQO-UHFFFAOYSA-N 0.000 claims 1
229960001265 ciclosporin Drugs 0.000 claims 1
229960004397 cyclophosphamide Drugs 0.000 claims 1
229930182912 cyclosporin Natural products 0.000 claims 1
229940126864 fibroblast growth factor Drugs 0.000 claims 1
229960004171 hydroxychloroquine Drugs 0.000 claims 1
XXSMGPRMXLTPCZ-UHFFFAOYSA-N hydroxychloroquine Chemical compound ClC1=CC=C2C(NC(C)CCCN(CCO)CC)=CC=NC2=C1 XXSMGPRMXLTPCZ-UHFFFAOYSA-N 0.000 claims 1
229960000901 mepacrine Drugs 0.000 claims 1
229960001810 meprednisone Drugs 0.000 claims 1
PIDANAQULIKBQS-RNUIGHNZSA-N meprednisone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)CC2=O PIDANAQULIKBQS-RNUIGHNZSA-N 0.000 claims 1
BLUYEPLOXLPVCJ-INIZCTEOSA-N n-[(1s)-2-[4-(3-aminopropylamino)butylamino]-1-hydroxyethyl]-7-(diaminomethylideneamino)heptanamide Chemical compound NCCCNCCCCNC[C@H](O)NC(=O)CCCCCCNC(N)=N BLUYEPLOXLPVCJ-INIZCTEOSA-N 0.000 claims 1
229960004618 prednisone Drugs 0.000 claims 1
XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 claims 1
GPKJTRJOBQGKQK-UHFFFAOYSA-N quinacrine Chemical compound C1=C(OC)C=C2C(NC(C)CCCN(CC)CC)=C(C=CC(Cl)=C3)C3=NC2=C1 GPKJTRJOBQGKQK-UHFFFAOYSA-N 0.000 claims 1
108020003175 receptors Proteins 0.000 abstract description 261
102000005962 receptors Human genes 0.000 abstract description 257
150000007523 nucleic acids Chemical class 0.000 abstract description 85
102000039446 nucleic acids Human genes 0.000 abstract description 73
108020004707 nucleic acids Proteins 0.000 abstract description 73
239000013598 vector Substances 0.000 abstract description 45
230000000694 effects Effects 0.000 abstract description 39
230000014509 gene expression Effects 0.000 abstract description 39
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 28
201000010099 disease Diseases 0.000 abstract description 20
239000000556 agonist Substances 0.000 abstract description 15
239000005557 antagonist Substances 0.000 abstract description 13
230000001594 aberrant effect Effects 0.000 abstract description 9
238000012216 screening Methods 0.000 abstract description 9
238000002560 therapeutic procedure Methods 0.000 abstract description 9
230000035755 proliferation Effects 0.000 abstract description 6
238000010188 recombinant method Methods 0.000 abstract description 6
238000002405 diagnostic procedure Methods 0.000 abstract description 5
230000024245 cell differentiation Effects 0.000 abstract description 2
235000018102 proteins Nutrition 0.000 description 191
108091033319 polynucleotide Proteins 0.000 description 180
102000040430 polynucleotide Human genes 0.000 description 180
239000002157 polynucleotide Substances 0.000 description 180
125000000539 amino acid group Chemical group 0.000 description 149
210000004027 cell Anatomy 0.000 description 139
125000003275 alpha amino acid group Chemical group 0.000 description 128
235000001014 amino acid Nutrition 0.000 description 113
229940024606 amino acid Drugs 0.000 description 100
239000002773 nucleotide Substances 0.000 description 78
125000003729 nucleotide group Chemical group 0.000 description 78
241000282414 Homo sapiens Species 0.000 description 70
239000012634 fragment Substances 0.000 description 61
230000027455 binding Effects 0.000 description 56
239000003446 ligand Substances 0.000 description 48
108020004414 DNA Proteins 0.000 description 41
108020001507 fusion proteins Proteins 0.000 description 40
102000037865 fusion proteins Human genes 0.000 description 40
241001465754 Metazoa Species 0.000 description 36
229920001223 polyethylene glycol Polymers 0.000 description 35
108091028043 Nucleic acid sequence Proteins 0.000 description 34
238000012217 deletion Methods 0.000 description 34
230000037430 deletion Effects 0.000 description 34
239000002202 Polyethylene glycol Substances 0.000 description 33
239000002299 complementary DNA Substances 0.000 description 31
108020004635 Complementary DNA Proteins 0.000 description 30
230000000890 antigenic effect Effects 0.000 description 28
230000004071 biological effect Effects 0.000 description 25
108020004999 messenger RNA Proteins 0.000 description 23
238000000746 purification Methods 0.000 description 23
238000006467 substitution reaction Methods 0.000 description 23
150000001875 compounds Chemical class 0.000 description 20
238000003018 immunoassay Methods 0.000 description 20
108091032973 (ribonucleotides)n+m Proteins 0.000 description 18
230000002163 immunogen Effects 0.000 description 18
108091026890 Coding region Proteins 0.000 description 17
108060003951 Immunoglobulin Proteins 0.000 description 17
238000003556 assay Methods 0.000 description 17
102000018358 immunoglobulin Human genes 0.000 description 17
210000001519 tissue Anatomy 0.000 description 17
108700019146 Transgenes Proteins 0.000 description 16
210000004408 hybridoma Anatomy 0.000 description 16
238000004519 manufacturing process Methods 0.000 description 16
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 16
238000004458 analytical method Methods 0.000 description 15
210000004899 c-terminal region Anatomy 0.000 description 15
125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 15
239000013604 expression vector Substances 0.000 description 15
230000009261 transgenic effect Effects 0.000 description 15
108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 description 14
230000004913 activation Effects 0.000 description 14
238000003776 cleavage reaction Methods 0.000 description 14
238000005516 engineering process Methods 0.000 description 14
230000007017 scission Effects 0.000 description 14
102000003298 tumor necrosis factor receptor Human genes 0.000 description 14
108700026244 Open Reading Frames Proteins 0.000 description 13
125000005647 linker group Chemical group 0.000 description 13
239000000047 product Substances 0.000 description 13
241000699670 Mus sp. Species 0.000 description 12
230000036755 cellular response Effects 0.000 description 12
238000006243 chemical reaction Methods 0.000 description 12
230000000295 complement effect Effects 0.000 description 12
230000001965 increasing effect Effects 0.000 description 12
230000001404 mediated effect Effects 0.000 description 12
210000004379 membrane Anatomy 0.000 description 12
239000012528 membrane Substances 0.000 description 12
238000002823 phage display Methods 0.000 description 12
230000000717 retained effect Effects 0.000 description 12
239000000126 substance Substances 0.000 description 12
230000001225 therapeutic effect Effects 0.000 description 12
238000009396 hybridization Methods 0.000 description 11
210000004962 mammalian cell Anatomy 0.000 description 11
239000013612 plasmid Substances 0.000 description 11
241000699666 Mus <mouse, genus> Species 0.000 description 10
108020004511 Recombinant DNA Proteins 0.000 description 10
-1 aliphatic amino acid Chemical class 0.000 description 10
230000004075 alteration Effects 0.000 description 10
230000028993 immune response Effects 0.000 description 10
230000003834 intracellular effect Effects 0.000 description 10
239000003550 marker Substances 0.000 description 10
230000004048 modification Effects 0.000 description 10
238000012986 modification Methods 0.000 description 10
241000124008 Mammalia Species 0.000 description 9
102100040247 Tumor necrosis factor Human genes 0.000 description 9
238000007792 addition Methods 0.000 description 9
239000012472 biological sample Substances 0.000 description 9
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 9
230000000875 corresponding effect Effects 0.000 description 9
238000001514 detection method Methods 0.000 description 9
238000000338 in vitro Methods 0.000 description 9
208000008190 Agammaglobulinemia Diseases 0.000 description 8
125000001433 C-terminal amino-acid group Chemical group 0.000 description 8
238000002965 ELISA Methods 0.000 description 8
206010020983 Hypogammaglobulinaemia Diseases 0.000 description 8
ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 8
ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 8
241000700605 Viruses Species 0.000 description 8
230000000903 blocking effect Effects 0.000 description 8
208000035475 disorder Diseases 0.000 description 8
210000002889 endothelial cell Anatomy 0.000 description 8
230000005714 functional activity Effects 0.000 description 8
238000003780 insertion Methods 0.000 description 8
230000037431 insertion Effects 0.000 description 8
239000000463 material Substances 0.000 description 8
238000002703 mutagenesis Methods 0.000 description 8
231100000350 mutagenesis Toxicity 0.000 description 8
241000894007 species Species 0.000 description 8
238000013519 translation Methods 0.000 description 8
102000004190 Enzymes Human genes 0.000 description 7
108090000790 Enzymes Proteins 0.000 description 7
241000238631 Hexapoda Species 0.000 description 7
241001529936 Murinae Species 0.000 description 7
125000000729 N-terminal amino-acid group Chemical group 0.000 description 7
239000011324 bead Substances 0.000 description 7
230000008827 biological function Effects 0.000 description 7
238000003745 diagnosis Methods 0.000 description 7
229940088598 enzyme Drugs 0.000 description 7
230000002068 genetic effect Effects 0.000 description 7
230000006698 induction Effects 0.000 description 7
238000012545 processing Methods 0.000 description 7
230000003248 secreting effect Effects 0.000 description 7
239000007787 solid Substances 0.000 description 7
239000000243 solution Substances 0.000 description 7
238000001262 western blot Methods 0.000 description 7
YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 6
101150013553 CD40 gene Proteins 0.000 description 6
108010047041 Complementarity Determining Regions Proteins 0.000 description 6
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 6
108091034117 Oligonucleotide Proteins 0.000 description 6
210000001744 T-lymphocyte Anatomy 0.000 description 6
CKLJMWTZIZZHCS-REOHCLBHSA-N aspartic acid group Chemical group N[C@@H](CC(=O)O)C(=O)O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 6
230000015572 biosynthetic process Effects 0.000 description 6
230000004663 cell proliferation Effects 0.000 description 6
238000010367 cloning Methods 0.000 description 6
238000004590 computer program Methods 0.000 description 6
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 6
235000018417 cysteine Nutrition 0.000 description 6
230000002209 hydrophobic effect Effects 0.000 description 6
230000001900 immune effect Effects 0.000 description 6
230000003053 immunization Effects 0.000 description 6
229940072221 immunoglobulins Drugs 0.000 description 6
230000003993 interaction Effects 0.000 description 6
230000003472 neutralizing effect Effects 0.000 description 6
238000003786 synthesis reaction Methods 0.000 description 6
241001529453 unidentified herpesvirus Species 0.000 description 6
241000894006 Bacteria Species 0.000 description 5
206010010099 Combined immunodeficiency Diseases 0.000 description 5
241000196324 Embryophyta Species 0.000 description 5
241000588724 Escherichia coli Species 0.000 description 5
102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 5
108090001005 Interleukin-6 Proteins 0.000 description 5
102000004889 Interleukin-6 Human genes 0.000 description 5
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 5
239000004472 Lysine Substances 0.000 description 5
241000283973 Oryctolagus cuniculus Species 0.000 description 5
240000004808 Saccharomyces cerevisiae Species 0.000 description 5
102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 description 5
239000002671 adjuvant Substances 0.000 description 5
230000001413 cellular effect Effects 0.000 description 5
210000004978 chinese hamster ovary cell Anatomy 0.000 description 5
210000000349 chromosome Anatomy 0.000 description 5
230000001268 conjugating effect Effects 0.000 description 5
238000011161 development Methods 0.000 description 5
230000018109 developmental process Effects 0.000 description 5
239000000539 dimer Substances 0.000 description 5
229940079593 drug Drugs 0.000 description 5
230000006870 function Effects 0.000 description 5
239000000499 gel Substances 0.000 description 5
230000013595 glycosylation Effects 0.000 description 5
238000006206 glycosylation reaction Methods 0.000 description 5
238000002649 immunization Methods 0.000 description 5
235000018977 lysine Nutrition 0.000 description 5
239000011159 matrix material Substances 0.000 description 5
125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 description 5
238000002360 preparation method Methods 0.000 description 5
230000008569 process Effects 0.000 description 5
230000006798 recombination Effects 0.000 description 5
239000000523 sample Substances 0.000 description 5
238000012163 sequencing technique Methods 0.000 description 5
239000007858 starting material Substances 0.000 description 5
230000035897 transcription Effects 0.000 description 5
238000013518 transcription Methods 0.000 description 5
238000005406 washing Methods 0.000 description 5
208000023275 Autoimmune disease Diseases 0.000 description 4
101100230428 Caenorhabditis elegans hil-5 gene Proteins 0.000 description 4
102000000844 Cell Surface Receptors Human genes 0.000 description 4
108010001857 Cell Surface Receptors Proteins 0.000 description 4
102000053602 DNA Human genes 0.000 description 4
BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 4
108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 4
108010093488 His-His-His-His-His-His Proteins 0.000 description 4
102000000589 Interleukin-1 Human genes 0.000 description 4
108010002352 Interleukin-1 Proteins 0.000 description 4
241000699660 Mus musculus Species 0.000 description 4
108091006006 PEGylated Proteins Proteins 0.000 description 4
239000004365 Protease Substances 0.000 description 4
108010076504 Protein Sorting Signals Proteins 0.000 description 4
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 4
230000021736 acetylation Effects 0.000 description 4
238000006640 acetylation reaction Methods 0.000 description 4
239000002253 acid Substances 0.000 description 4
230000003302 anti-idiotype Effects 0.000 description 4
230000002788 anti-peptide Effects 0.000 description 4
238000013459 approach Methods 0.000 description 4
230000001580 bacterial effect Effects 0.000 description 4
210000001124 body fluid Anatomy 0.000 description 4
239000010839 body fluid Substances 0.000 description 4
239000013592 cell lysate Substances 0.000 description 4
230000002759 chromosomal effect Effects 0.000 description 4
238000012875 competitive assay Methods 0.000 description 4
238000012937 correction Methods 0.000 description 4
231100000599 cytotoxic agent Toxicity 0.000 description 4
230000003013 cytotoxicity Effects 0.000 description 4
231100000135 cytotoxicity Toxicity 0.000 description 4
230000003247 decreasing effect Effects 0.000 description 4
238000001212 derivatisation Methods 0.000 description 4
210000001671 embryonic stem cell Anatomy 0.000 description 4
239000004120 green S Substances 0.000 description 4
HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 4
235000014304 histidine Nutrition 0.000 description 4
238000002744 homologous recombination Methods 0.000 description 4
230000006801 homologous recombination Effects 0.000 description 4
239000002502 liposome Substances 0.000 description 4
210000004698 lymphocyte Anatomy 0.000 description 4
230000002503 metabolic effect Effects 0.000 description 4
229930182817 methionine Natural products 0.000 description 4
238000007799 mixed lymphocyte reaction assay Methods 0.000 description 4
210000001616 monocyte Anatomy 0.000 description 4
230000035772 mutation Effects 0.000 description 4
238000011275 oncology therapy Methods 0.000 description 4
230000006320 pegylation Effects 0.000 description 4
230000026731 phosphorylation Effects 0.000 description 4
238000006366 phosphorylation reaction Methods 0.000 description 4
229920002401 polyacrylamide Polymers 0.000 description 4
230000003389 potentiating effect Effects 0.000 description 4
230000006337 proteolytic cleavage Effects 0.000 description 4
238000003127 radioimmunoassay Methods 0.000 description 4
238000005215 recombination Methods 0.000 description 4
230000001105 regulatory effect Effects 0.000 description 4
230000028327 secretion Effects 0.000 description 4
238000002741 site-directed mutagenesis Methods 0.000 description 4
210000000952 spleen Anatomy 0.000 description 4
239000000758 substrate Substances 0.000 description 4
238000001890 transfection Methods 0.000 description 4
238000012546 transfer Methods 0.000 description 4
238000011830 transgenic mouse model Methods 0.000 description 4
239000013638 trimer Substances 0.000 description 4
241000701161 unidentified adenovirus Species 0.000 description 4
FUOOLUPWFVMBKG-UHFFFAOYSA-N 2-Aminoisobutyric acid Chemical compound CC(C)(N)C(O)=O FUOOLUPWFVMBKG-UHFFFAOYSA-N 0.000 description 3
102000002260 Alkaline Phosphatase Human genes 0.000 description 3
108020004774 Alkaline Phosphatase Proteins 0.000 description 3
108020004705 Codon Proteins 0.000 description 3
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
206010018364 Glomerulonephritis Diseases 0.000 description 3
WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 3
102000005720 Glutathione transferase Human genes 0.000 description 3
108010070675 Glutathione transferase Proteins 0.000 description 3
108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 description 3
102100039619 Granulocyte colony-stimulating factor Human genes 0.000 description 3
101710154606 Hemagglutinin Proteins 0.000 description 3
241000282412 Homo Species 0.000 description 3
108010001336 Horseradish Peroxidase Proteins 0.000 description 3
108090000144 Human Proteins Proteins 0.000 description 3
102000003839 Human Proteins Human genes 0.000 description 3
108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 3
102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 3
108700005091 Immunoglobulin Genes Proteins 0.000 description 3
108010002350 Interleukin-2 Proteins 0.000 description 3
102000000588 Interleukin-2 Human genes 0.000 description 3
XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 3
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 3
HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 3
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 3
208000030289 Lymphoproliferative disease Diseases 0.000 description 3
238000000636 Northern blotting Methods 0.000 description 3
101710093908 Outer capsid protein VP4 Proteins 0.000 description 3
101710135467 Outer capsid protein sigma-1 Proteins 0.000 description 3
108090000526 Papain Proteins 0.000 description 3
101710176177 Protein A56 Proteins 0.000 description 3
241000700159 Rattus Species 0.000 description 3
206010052779 Transplant rejections Diseases 0.000 description 3
238000007818 agglutination assay Methods 0.000 description 3
238000012867 alanine scanning Methods 0.000 description 3
QWCKQJZIFLGMSD-UHFFFAOYSA-N alpha-aminobutyric acid Chemical compound CCC(N)C(O)=O QWCKQJZIFLGMSD-UHFFFAOYSA-N 0.000 description 3
125000003277 amino group Chemical group 0.000 description 3
235000003704 aspartic acid Nutrition 0.000 description 3
230000001363 autoimmune Effects 0.000 description 3
OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 3
235000020958 biotin Nutrition 0.000 description 3
229960002685 biotin Drugs 0.000 description 3
239000011616 biotin Substances 0.000 description 3
210000002459 blastocyst Anatomy 0.000 description 3
150000001720 carbohydrates Chemical class 0.000 description 3
238000007385 chemical modification Methods 0.000 description 3
238000002512 chemotherapy Methods 0.000 description 3
238000004587 chromatography analysis Methods 0.000 description 3
230000021615 conjugation Effects 0.000 description 3
238000007796 conventional method Methods 0.000 description 3
230000008878 coupling Effects 0.000 description 3
238000010168 coupling process Methods 0.000 description 3
238000005859 coupling reaction Methods 0.000 description 3
239000012636 effector Substances 0.000 description 3
238000004520 electroporation Methods 0.000 description 3
239000003623 enhancer Substances 0.000 description 3
230000002255 enzymatic effect Effects 0.000 description 3
210000002950 fibroblast Anatomy 0.000 description 3
239000012530 fluid Substances 0.000 description 3
230000004927 fusion Effects 0.000 description 3
229960002989 glutamic acid Drugs 0.000 description 3
235000013922 glutamic acid Nutrition 0.000 description 3
239000004220 glutamic acid Substances 0.000 description 3
125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 description 3
239000003102 growth factor Substances 0.000 description 3
239000000710 homodimer Substances 0.000 description 3
RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 3
238000001114 immunoprecipitation Methods 0.000 description 3
230000001939 inductive effect Effects 0.000 description 3
206010022000 influenza Diseases 0.000 description 3
230000002401 inhibitory effect Effects 0.000 description 3
230000005764 inhibitory process Effects 0.000 description 3
230000000977 initiatory effect Effects 0.000 description 3
230000010354 integration Effects 0.000 description 3
230000004807 localization Effects 0.000 description 3
125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 3
229910021645 metal ion Inorganic materials 0.000 description 3
230000003278 mimic effect Effects 0.000 description 3
239000000178 monomer Substances 0.000 description 3
230000006654 negative regulation of apoptotic process Effects 0.000 description 3
210000002569 neuron Anatomy 0.000 description 3
229940055729 papain Drugs 0.000 description 3
235000019834 papain Nutrition 0.000 description 3
239000008194 pharmaceutical composition Substances 0.000 description 3
229920000642 polymer Polymers 0.000 description 3
238000003259 recombinant expression Methods 0.000 description 3
230000026267 regulation of growth Effects 0.000 description 3
238000012552 review Methods 0.000 description 3
210000004988 splenocyte Anatomy 0.000 description 3
230000004083 survival effect Effects 0.000 description 3
230000003612 virological effect Effects 0.000 description 3
239000011534 wash buffer Substances 0.000 description 3
MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 2
VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 2
CXCHEKCRJQRVNG-UHFFFAOYSA-N 2,2,2-trifluoroethanesulfonyl chloride Chemical compound FC(F)(F)CS(Cl)(=O)=O CXCHEKCRJQRVNG-UHFFFAOYSA-N 0.000 description 2
229920000936 Agarose Polymers 0.000 description 2
108010039627 Aprotinin Proteins 0.000 description 2
239000004475 Arginine Substances 0.000 description 2
DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 2
201000010717 Bruton-type agammaglobulinemia Diseases 0.000 description 2
241000283707 Capra Species 0.000 description 2
108010067225 Cell Adhesion Molecules Proteins 0.000 description 2
102000016289 Cell Adhesion Molecules Human genes 0.000 description 2
206010063094 Cerebral malaria Diseases 0.000 description 2
108091033380 Coding strand Proteins 0.000 description 2
102100038385 Coiled-coil domain-containing protein R3HCC1L Human genes 0.000 description 2
201000003874 Common Variable Immunodeficiency Diseases 0.000 description 2
101710112752 Cytotoxin Proteins 0.000 description 2
230000005778 DNA damage Effects 0.000 description 2
231100000277 DNA damage Toxicity 0.000 description 2
229920002307 Dextran Polymers 0.000 description 2
241000255581 Drosophila <fruit fly, genus> Species 0.000 description 2
206010059866 Drug resistance Diseases 0.000 description 2
108010024212 E-Selectin Proteins 0.000 description 2
102100023471 E-selectin Human genes 0.000 description 2
241000724791 Filamentous phage Species 0.000 description 2
ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 2
108010051696 Growth Hormone Proteins 0.000 description 2
208000030836 Hashimoto thyroiditis Diseases 0.000 description 2
208000035186 Hemolytic Autoimmune Anemia Diseases 0.000 description 2
101000801228 Homo sapiens Tumor necrosis factor receptor superfamily member 1A Proteins 0.000 description 2
208000007924 IgA Deficiency Diseases 0.000 description 2
208000010159 IgA glomerulonephritis Diseases 0.000 description 2
206010021263 IgA nephropathy Diseases 0.000 description 2
108010009817 Immunoglobulin Constant Regions Proteins 0.000 description 2
102000009786 Immunoglobulin Constant Regions Human genes 0.000 description 2
108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 description 2
102100037877 Intercellular adhesion molecule 1 Human genes 0.000 description 2
108010050904 Interferons Proteins 0.000 description 2
102000014150 Interferons Human genes 0.000 description 2
108091092195 Intron Proteins 0.000 description 2
DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 2
COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 2
OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 2
GQYIWUVLTXOXAJ-UHFFFAOYSA-N Lomustine Chemical compound ClCCN(N=O)C(=O)NC1CCCCC1 GQYIWUVLTXOXAJ-UHFFFAOYSA-N 0.000 description 2
102000008072 Lymphokines Human genes 0.000 description 2
108010074338 Lymphokines Proteins 0.000 description 2
108700018351 Major Histocompatibility Complex Proteins 0.000 description 2
206010028851 Necrosis Diseases 0.000 description 2
239000004677 Nylon Substances 0.000 description 2
102000057297 Pepsin A Human genes 0.000 description 2
108090000284 Pepsin A Proteins 0.000 description 2
206010035226 Plasma cell myeloma Diseases 0.000 description 2
101710182846 Polyhedrin Proteins 0.000 description 2
108010029485 Protein Isoforms Proteins 0.000 description 2
102000001708 Protein Isoforms Human genes 0.000 description 2
108010007127 Pulmonary Surfactant-Associated Protein D Proteins 0.000 description 2
102100027845 Pulmonary surfactant-associated protein D Human genes 0.000 description 2
108700017801 Purine Nucleoside Phosphorylase Deficiency Proteins 0.000 description 2
206010037549 Purpura Diseases 0.000 description 2
241001672981 Purpura Species 0.000 description 2
108010008281 Recombinant Fusion Proteins Proteins 0.000 description 2
102000007056 Recombinant Fusion Proteins Human genes 0.000 description 2
239000004231 Riboflavin-5-Sodium Phosphate Substances 0.000 description 2
101150001535 SRC gene Proteins 0.000 description 2
DYAHQFWOVKZOOW-UHFFFAOYSA-N Sarin Chemical compound CC(C)OP(C)(F)=O DYAHQFWOVKZOOW-UHFFFAOYSA-N 0.000 description 2
206010039915 Selective IgA immunodeficiency Diseases 0.000 description 2
229920002684 Sepharose Polymers 0.000 description 2
206010040070 Septic Shock Diseases 0.000 description 2
238000012300 Sequence Analysis Methods 0.000 description 2
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 2
102100038803 Somatotropin Human genes 0.000 description 2
108091081024 Start codon Proteins 0.000 description 2
108010092262 T-Cell Antigen Receptors Proteins 0.000 description 2
102000016266 T-Cell Antigen Receptors Human genes 0.000 description 2
AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 2
239000004473 Threonine Substances 0.000 description 2
IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 2
241000723873 Tobacco mosaic virus Species 0.000 description 2
102100031988 Tumor necrosis factor ligand superfamily member 6 Human genes 0.000 description 2
108050002568 Tumor necrosis factor ligand superfamily member 6 Proteins 0.000 description 2
102100033732 Tumor necrosis factor receptor superfamily member 1A Human genes 0.000 description 2
206010054094 Tumour necrosis Diseases 0.000 description 2
VGQOVCHZGQWAOI-UHFFFAOYSA-N UNPD55612 Natural products N1C(O)C2CC(C=CC(N)=O)=CN2C(=O)C2=CC=C(C)C(O)=C12 VGQOVCHZGQWAOI-UHFFFAOYSA-N 0.000 description 2
241000700618 Vaccinia virus Species 0.000 description 2
108010000134 Vascular Cell Adhesion Molecule-1 Proteins 0.000 description 2
102100023543 Vascular cell adhesion protein 1 Human genes 0.000 description 2
JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 description 2
208000006110 Wiskott-Aldrich syndrome Diseases 0.000 description 2
208000016349 X-linked agammaglobulinemia Diseases 0.000 description 2
206010068348 X-linked lymphoproliferative syndrome Diseases 0.000 description 2
239000004234 Yellow 2G Substances 0.000 description 2
230000035508 accumulation Effects 0.000 description 2
238000009825 accumulation Methods 0.000 description 2
150000007513 acids Chemical class 0.000 description 2
230000001800 adrenalinergic effect Effects 0.000 description 2
238000001042 affinity chromatography Methods 0.000 description 2
230000002776 aggregation Effects 0.000 description 2
238000004220 aggregation Methods 0.000 description 2
239000004191 allura red AC Substances 0.000 description 2
230000009435 amidation Effects 0.000 description 2
238000007112 amidation reaction Methods 0.000 description 2
230000003321 amplification Effects 0.000 description 2
VGQOVCHZGQWAOI-HYUHUPJXSA-N anthramycin Chemical compound N1[C@@H](O)[C@@H]2CC(\C=C\C(N)=O)=CN2C(=O)C2=CC=C(C)C(O)=C12 VGQOVCHZGQWAOI-HYUHUPJXSA-N 0.000 description 2
230000000840 anti-viral effect Effects 0.000 description 2
230000009830 antibody antigen interaction Effects 0.000 description 2
230000005875 antibody response Effects 0.000 description 2
238000003782 apoptosis assay Methods 0.000 description 2
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 2
235000009582 asparagine Nutrition 0.000 description 2
229960001230 asparagine Drugs 0.000 description 2
208000006673 asthma Diseases 0.000 description 2
201000000448 autoimmune hemolytic anemia Diseases 0.000 description 2
201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 description 2
208000036556 autosomal recessive T cell-negative B cell-negative NK cell-negative due to adenosine deaminase deficiency severe combined immunodeficiency Diseases 0.000 description 2
230000008901 benefit Effects 0.000 description 2
102000005936 beta-Galactosidase Human genes 0.000 description 2
108010005774 beta-Galactosidase Proteins 0.000 description 2
UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 description 2
230000031018 biological processes and functions Effects 0.000 description 2
238000001574 biopsy Methods 0.000 description 2
210000004369 blood Anatomy 0.000 description 2
239000008280 blood Substances 0.000 description 2
238000009395 breeding Methods 0.000 description 2
230000001488 breeding effect Effects 0.000 description 2
239000004161 brilliant blue FCF Substances 0.000 description 2
239000004109 brown FK Substances 0.000 description 2
239000000872 buffer Substances 0.000 description 2
239000001506 calcium phosphate Substances 0.000 description 2
229910000389 calcium phosphate Inorganic materials 0.000 description 2
235000011010 calcium phosphates Nutrition 0.000 description 2
239000004106 carminic acid Substances 0.000 description 2
239000000969 carrier Substances 0.000 description 2
238000012219 cassette mutagenesis Methods 0.000 description 2
238000004113 cell culture Methods 0.000 description 2
DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 2
239000011248 coating agent Substances 0.000 description 2
238000000576 coating method Methods 0.000 description 2
230000002860 competitive effect Effects 0.000 description 2
239000004121 copper complexes of chlorophylls and chlorophyllins Substances 0.000 description 2
230000009260 cross reactivity Effects 0.000 description 2
238000012258 culturing Methods 0.000 description 2
XVOYSCVBGLVSOL-UHFFFAOYSA-N cysteic acid Chemical compound OC(=O)C(N)CS(O)(=O)=O XVOYSCVBGLVSOL-UHFFFAOYSA-N 0.000 description 2
OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 description 2
239000002254 cytotoxic agent Substances 0.000 description 2
239000002619 cytotoxin Substances 0.000 description 2
230000007423 decrease Effects 0.000 description 2
230000005860 defense response to virus Effects 0.000 description 2
230000002939 deleterious effect Effects 0.000 description 2
238000004925 denaturation Methods 0.000 description 2
230000036425 denaturation Effects 0.000 description 2
CFCUWKMKBJTWLW-UHFFFAOYSA-N deoliosyl-3C-alpha-L-digitoxosyl-MTM Natural products CC=1C(O)=C2C(O)=C3C(=O)C(OC4OC(C)C(O)C(OC5OC(C)C(O)C(OC6OC(C)C(O)C(C)(O)C6)C5)C4)C(C(OC)C(=O)C(O)C(C)O)CC3=CC2=CC=1OC(OC(C)C1O)CC1OC1CC(O)C(O)C(C)O1 CFCUWKMKBJTWLW-UHFFFAOYSA-N 0.000 description 2
230000001419 dependent effect Effects 0.000 description 2
229960002086 dextran Drugs 0.000 description 2
206010012601 diabetes mellitus Diseases 0.000 description 2
230000004069 differentiation Effects 0.000 description 2
208000037765 diseases and disorders Diseases 0.000 description 2
238000010494 dissociation reaction Methods 0.000 description 2
230000005593 dissociations Effects 0.000 description 2
230000006334 disulfide bridging Effects 0.000 description 2
238000012377 drug delivery Methods 0.000 description 2
238000007876 drug discovery Methods 0.000 description 2
238000010828 elution Methods 0.000 description 2
210000002257 embryonic structure Anatomy 0.000 description 2
239000000839 emulsion Substances 0.000 description 2
210000003038 endothelium Anatomy 0.000 description 2
210000003989 endothelium vascular Anatomy 0.000 description 2
210000003527 eukaryotic cell Anatomy 0.000 description 2
230000001747 exhibiting effect Effects 0.000 description 2
GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 2
230000022244 formylation Effects 0.000 description 2
238000006170 formylation reaction Methods 0.000 description 2
BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 2
238000012817 gel-diffusion technique Methods 0.000 description 2
238000010363 gene targeting Methods 0.000 description 2
238000002873 global sequence alignment Methods 0.000 description 2
ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 2
RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
125000003827 glycol group Chemical group 0.000 description 2
210000000224 granular leucocyte Anatomy 0.000 description 2
239000000122 growth hormone Substances 0.000 description 2
UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 2
239000000833 heterodimer Substances 0.000 description 2
238000012188 high-throughput screening assay Methods 0.000 description 2
210000005260 human cell Anatomy 0.000 description 2
210000000987 immune system Anatomy 0.000 description 2
230000000951 immunodiffusion Effects 0.000 description 2
230000005847 immunogenicity Effects 0.000 description 2
201000007156 immunoglobulin alpha deficiency Diseases 0.000 description 2
230000003308 immunostimulating effect Effects 0.000 description 2
230000001976 improved effect Effects 0.000 description 2
238000007901 in situ hybridization Methods 0.000 description 2
238000011534 incubation Methods 0.000 description 2
230000002757 inflammatory effect Effects 0.000 description 2
238000002347 injection Methods 0.000 description 2
239000007924 injection Substances 0.000 description 2
229940079322 interferon Drugs 0.000 description 2
229940047124 interferons Drugs 0.000 description 2
230000005865 ionizing radiation Effects 0.000 description 2
238000005304 joining Methods 0.000 description 2
239000004310 lactic acid Substances 0.000 description 2
230000003859 lipid peroxidation Effects 0.000 description 2
210000004072 lung Anatomy 0.000 description 2
206010025135 lupus erythematosus Diseases 0.000 description 2
210000005210 lymphoid organ Anatomy 0.000 description 2
239000012139 lysis buffer Substances 0.000 description 2
201000001441 melanoma Diseases 0.000 description 2
GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 description 2
CFCUWKMKBJTWLW-BKHRDMLASA-N mithramycin Chemical compound O([C@@H]1C[C@@H](O[C@H](C)[C@H]1O)OC=1C=C2C=C3C[C@H]([C@@H](C(=O)C3=C(O)C2=C(O)C=1C)O[C@@H]1O[C@H](C)[C@@H](O)[C@H](O[C@@H]2O[C@H](C)[C@H](O)[C@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@@](C)(O)C3)C2)C1)[C@H](OC)C(=O)[C@@H](O)[C@@H](C)O)[C@H]1C[C@@H](O)[C@H](O)[C@@H](C)O1 CFCUWKMKBJTWLW-BKHRDMLASA-N 0.000 description 2
DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 2
230000004660 morphological change Effects 0.000 description 2
201000000050 myeloid neoplasm Diseases 0.000 description 2
230000017074 necrotic cell death Effects 0.000 description 2
230000036963 noncompetitive effect Effects 0.000 description 2
238000003199 nucleic acid amplification method Methods 0.000 description 2
229920001778 nylon Polymers 0.000 description 2
239000002245 particle Substances 0.000 description 2
229940111202 pepsin Drugs 0.000 description 2
210000005259 peripheral blood Anatomy 0.000 description 2
239000011886 peripheral blood Substances 0.000 description 2
230000002093 peripheral effect Effects 0.000 description 2
COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 2
YBYRMVIVWMBXKQ-UHFFFAOYSA-N phenylmethanesulfonyl fluoride Chemical compound FS(=O)(=O)CC1=CC=CC=C1 YBYRMVIVWMBXKQ-UHFFFAOYSA-N 0.000 description 2
210000002381 plasma Anatomy 0.000 description 2
229960003171 plicamycin Drugs 0.000 description 2
230000008488 polyadenylation Effects 0.000 description 2
239000004304 potassium nitrite Substances 0.000 description 2
239000002244 precipitate Substances 0.000 description 2
238000001556 precipitation Methods 0.000 description 2
230000005522 programmed cell death Effects 0.000 description 2
AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 2
208000001917 purine nucleoside phosphorylase deficiency Diseases 0.000 description 2
RXWNCPJZOCPEPQ-NVWDDTSBSA-N puromycin Chemical compound C1=CC(OC)=CC=C1C[C@H](N)C(=O)N[C@H]1[C@@H](O)[C@H](N2C3=NC=NC(=C3N=C2)N(C)C)O[C@@H]1CO RXWNCPJZOCPEPQ-NVWDDTSBSA-N 0.000 description 2
230000002285 radioactive effect Effects 0.000 description 2
239000012857 radioactive material Substances 0.000 description 2
230000009257 reactivity Effects 0.000 description 2
230000009467 reduction Effects 0.000 description 2
238000006722 reduction reaction Methods 0.000 description 2
238000012340 reverse transcriptase PCR Methods 0.000 description 2
206010039073 rheumatoid arthritis Diseases 0.000 description 2
239000002151 riboflavin Substances 0.000 description 2
FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 description 2
238000010187 selection method Methods 0.000 description 2
208000029138 selective IgA deficiency disease Diseases 0.000 description 2
230000036303 septic shock Effects 0.000 description 2
238000002864 sequence alignment Methods 0.000 description 2
210000002966 serum Anatomy 0.000 description 2
208000002491 severe combined immunodeficiency Diseases 0.000 description 2
230000019491 signal transduction Effects 0.000 description 2
230000011664 signaling Effects 0.000 description 2
238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 2
239000004317 sodium nitrate Substances 0.000 description 2
239000001488 sodium phosphate Substances 0.000 description 2
229910000162 sodium phosphate Inorganic materials 0.000 description 2
238000001179 sorption measurement Methods 0.000 description 2
238000010561 standard procedure Methods 0.000 description 2
210000000130 stem cell Anatomy 0.000 description 2
230000000638 stimulation Effects 0.000 description 2
UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 description 2
229940126585 therapeutic drug Drugs 0.000 description 2
125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 description 2
RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 description 2
210000001541 thymus gland Anatomy 0.000 description 2
WYWHKKSPHMUBEB-UHFFFAOYSA-N tioguanine Chemical compound N1C(N)=NC(=S)C2=C1N=CN2 WYWHKKSPHMUBEB-UHFFFAOYSA-N 0.000 description 2
239000003053 toxin Substances 0.000 description 2
231100000765 toxin Toxicity 0.000 description 2
108700012359 toxins Proteins 0.000 description 2
238000010361 transduction Methods 0.000 description 2
230000026683 transduction Effects 0.000 description 2
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 2
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 2
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 2
241000701447 unidentified baculovirus Species 0.000 description 2
210000002700 urine Anatomy 0.000 description 2
MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 2
229960003048 vinblastine Drugs 0.000 description 2
JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 2
229960004528 vincristine Drugs 0.000 description 2
OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 2
OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 2
DIGQNXIGRZPYDK-WKSCXVIASA-N (2R)-6-amino-2-[[2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-[[(2R,3S)-2-[[2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S,3S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[2-[[2-[[2-[(2-amino-1-hydroxyethylidene)amino]-3-carboxy-1-hydroxypropylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1,5-dihydroxy-5-iminopentylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxyethylidene]amino]hexanoic acid Chemical compound C[C@@H]([C@@H](C(=N[C@@H](CS)C(=N[C@@H](C)C(=N[C@@H](CO)C(=NCC(=N[C@@H](CCC(=N)O)C(=NC(CS)C(=N[C@H]([C@H](C)O)C(=N[C@H](CS)C(=N[C@H](CO)C(=NCC(=N[C@H](CS)C(=NCC(=N[C@H](CCCCN)C(=O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)N=C([C@H](CS)N=C([C@H](CO)N=C([C@H](CO)N=C([C@H](C)N=C(CN=C([C@H](CO)N=C([C@H](CS)N=C(CN=C(C(CS)N=C(C(CC(=O)O)N=C(CN)O)O)O)O)O)O)O)O)O)O)O)O DIGQNXIGRZPYDK-WKSCXVIASA-N 0.000 description 1
BVAUMRCGVHUWOZ-ZETCQYMHSA-N (2s)-2-(cyclohexylazaniumyl)propanoate Chemical compound OC(=O)[C@H](C)NC1CCCCC1 BVAUMRCGVHUWOZ-ZETCQYMHSA-N 0.000 description 1
MRTPISKDZDHEQI-YFKPBYRVSA-N (2s)-2-(tert-butylamino)propanoic acid Chemical compound OC(=O)[C@H](C)NC(C)(C)C MRTPISKDZDHEQI-YFKPBYRVSA-N 0.000 description 1
NPDBDJFLKKQMCM-SCSAIBSYSA-N (2s)-2-amino-3,3-dimethylbutanoic acid Chemical compound CC(C)(C)[C@H](N)C(O)=O NPDBDJFLKKQMCM-SCSAIBSYSA-N 0.000 description 1
KUHSEZKIEJYEHN-BXRBKJIMSA-N (2s)-2-amino-3-hydroxypropanoic acid;(2s)-2-aminopropanoic acid Chemical compound C[C@H](N)C(O)=O.OC[C@H](N)C(O)=O KUHSEZKIEJYEHN-BXRBKJIMSA-N 0.000 description 1
PSLCKQYQNVNTQI-BHFSHLQUSA-N (2s)-2-aminobutanedioic acid;(2s)-2-aminopentanedioic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O.OC(=O)[C@@H](N)CCC(O)=O PSLCKQYQNVNTQI-BHFSHLQUSA-N 0.000 description 1
ASWBNKHCZGQVJV-UHFFFAOYSA-N (3-hexadecanoyloxy-2-hydroxypropyl) 2-(trimethylazaniumyl)ethyl phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(O)COP([O-])(=O)OCC[N+](C)(C)C ASWBNKHCZGQVJV-UHFFFAOYSA-N 0.000 description 1
FDKXTQMXEQVLRF-ZHACJKMWSA-N (E)-dacarbazine Chemical compound CN(C)\N=N\c1[nH]cnc1C(N)=O FDKXTQMXEQVLRF-ZHACJKMWSA-N 0.000 description 1
IAKHMKGGTNLKSZ-INIZCTEOSA-N (S)-colchicine Chemical compound C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 description 1
OGNSCSPNOLGXSM-UHFFFAOYSA-N 2,4-diaminobutyric acid Chemical compound NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 description 1
UFBJCMHMOXMLKC-UHFFFAOYSA-N 2,4-dinitrophenol Chemical compound OC1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O UFBJCMHMOXMLKC-UHFFFAOYSA-N 0.000 description 1
QRYXYRQPMWQIDM-UHFFFAOYSA-N 3-benzoyl-3-(2,5-dioxopyrrol-1-yl)-1-hydroxypyrrolidine-2,5-dione Chemical compound O=C1N(O)C(=O)CC1(C(=O)C=1C=CC=CC=1)N1C(=O)C=CC1=O QRYXYRQPMWQIDM-UHFFFAOYSA-N 0.000 description 1
SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 description 1
CJIJXIFQYOPWTF-UHFFFAOYSA-N 7-hydroxycoumarin Natural products O1C(=O)C=CC2=CC(O)=CC=C21 CJIJXIFQYOPWTF-UHFFFAOYSA-N 0.000 description 1
108010066676 Abrin Proteins 0.000 description 1
102000012440 Acetylcholinesterase Human genes 0.000 description 1
108010022752 Acetylcholinesterase Proteins 0.000 description 1
206010069754 Acquired gene mutation Diseases 0.000 description 1
208000026872 Addison Disease Diseases 0.000 description 1
229930024421 Adenine Natural products 0.000 description 1
GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 1
102100029457 Adenine phosphoribosyltransferase Human genes 0.000 description 1
108010024223 Adenine phosphoribosyltransferase Proteins 0.000 description 1
108010000239 Aequorin Proteins 0.000 description 1
102100027211 Albumin Human genes 0.000 description 1
108010088751 Albumins Proteins 0.000 description 1
102400000068 Angiostatin Human genes 0.000 description 1
108010079709 Angiostatins Proteins 0.000 description 1
208000003343 Antiphospholipid Syndrome Diseases 0.000 description 1
241001550224 Apha Species 0.000 description 1
206010002961 Aplasia Diseases 0.000 description 1
101001084702 Arabidopsis thaliana Histone H2B.10 Proteins 0.000 description 1
101000878595 Arabidopsis thaliana Squalene synthase 1 Proteins 0.000 description 1
206010003445 Ascites Diseases 0.000 description 1
206010003594 Ataxia telangiectasia Diseases 0.000 description 1
102100022717 Atypical chemokine receptor 1 Human genes 0.000 description 1
241000972773 Aulopiformes Species 0.000 description 1
208000032116 Autoimmune Experimental Encephalomyelitis Diseases 0.000 description 1
206010055128 Autoimmune neutropenia Diseases 0.000 description 1
241000271566 Aves Species 0.000 description 1
108090001008 Avidin Proteins 0.000 description 1
102100024222 B-lymphocyte antigen CD19 Human genes 0.000 description 1
108091007065 BIRCs Proteins 0.000 description 1
208000023328 Basedow disease Diseases 0.000 description 1
DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 1
102100023995 Beta-nerve growth factor Human genes 0.000 description 1
208000008439 Biliary Liver Cirrhosis Diseases 0.000 description 1
208000033222 Biliary cirrhosis primary Diseases 0.000 description 1
241000283690 Bos taurus Species 0.000 description 1
206010006187 Breast cancer Diseases 0.000 description 1
208000026310 Breast neoplasm Diseases 0.000 description 1
208000023706 Bruton agammaglobulinaemia Diseases 0.000 description 1
COVZYZSDYWQREU-UHFFFAOYSA-N Busulfan Chemical compound CS(=O)(=O)OCCCCOS(C)(=O)=O COVZYZSDYWQREU-UHFFFAOYSA-N 0.000 description 1
102100027207 CD27 antigen Human genes 0.000 description 1
240000001432 Calendula officinalis Species 0.000 description 1
235000005881 Calendula officinalis Nutrition 0.000 description 1
241000282836 Camelus dromedarius Species 0.000 description 1
229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
201000009030 Carcinoma Diseases 0.000 description 1
DLGOEMSEDOSKAD-UHFFFAOYSA-N Carmustine Chemical compound ClCCNC(=O)N(N=O)CCCl DLGOEMSEDOSKAD-UHFFFAOYSA-N 0.000 description 1
102000014914 Carrier Proteins Human genes 0.000 description 1
108010078791 Carrier Proteins Proteins 0.000 description 1
241000701489 Cauliflower mosaic virus Species 0.000 description 1
241000700198 Cavia Species 0.000 description 1
241000700199 Cavia porcellus Species 0.000 description 1
102100025064 Cellular tumor antigen p53 Human genes 0.000 description 1
241000282693 Cercopithecidae Species 0.000 description 1
206010008909 Chronic Hepatitis Diseases 0.000 description 1
108090000317 Chymotrypsin Proteins 0.000 description 1
206010009900 Colitis ulcerative Diseases 0.000 description 1
206010009944 Colon cancer Diseases 0.000 description 1
108010071942 Colony-Stimulating Factors Proteins 0.000 description 1
206010010356 Congenital anomaly Diseases 0.000 description 1
241000699800 Cricetinae Species 0.000 description 1
201000003883 Cystic fibrosis Diseases 0.000 description 1
UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 description 1
IGXWBGJHJZYPQS-SSDOTTSWSA-N D-Luciferin Chemical compound OC(=O)[C@H]1CSC(C=2SC3=CC=C(O)C=C3N=2)=N1 IGXWBGJHJZYPQS-SSDOTTSWSA-N 0.000 description 1
101150074155 DHFR gene Proteins 0.000 description 1
230000004544 DNA amplification Effects 0.000 description 1
238000001712 DNA sequencing Methods 0.000 description 1
102000052510 DNA-Binding Proteins Human genes 0.000 description 1
108700020911 DNA-Binding Proteins Proteins 0.000 description 1
XPDXVDYUQZHFPV-UHFFFAOYSA-N Dansyl Chloride Chemical compound C1=CC=C2C(N(C)C)=CC=CC2=C1S(Cl)(=O)=O XPDXVDYUQZHFPV-UHFFFAOYSA-N 0.000 description 1
WEAHRLBPCANXCN-UHFFFAOYSA-N Daunomycin Natural products CCC1(O)CC(OC2CC(N)C(O)C(C)O2)c3cc4C(=O)c5c(OC)cccc5C(=O)c4c(O)c3C1 WEAHRLBPCANXCN-UHFFFAOYSA-N 0.000 description 1
206010011878 Deafness Diseases 0.000 description 1
CYCGRDQQIOGCKX-UHFFFAOYSA-N Dehydro-luciferin Natural products OC(=O)C1=CSC(C=2SC3=CC(O)=CC=C3N=2)=N1 CYCGRDQQIOGCKX-UHFFFAOYSA-N 0.000 description 1
201000004624 Dermatitis Diseases 0.000 description 1
206010012438 Dermatitis atopic Diseases 0.000 description 1
108010053187 Diphtheria Toxin Proteins 0.000 description 1
102000016607 Diphtheria Toxin Human genes 0.000 description 1
206010013883 Dwarfism Diseases 0.000 description 1
201000009084 Dysgammaglobulinemia Diseases 0.000 description 1
206010058314 Dysplasia Diseases 0.000 description 1
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
238000012286 ELISA Assay Methods 0.000 description 1
MBYXEBXZARTUSS-QLWBXOBMSA-N Emetamine Natural products O(C)c1c(OC)cc2c(c(C[C@@H]3[C@H](CC)CN4[C@H](c5c(cc(OC)c(OC)c5)CC4)C3)ncc2)c1 MBYXEBXZARTUSS-QLWBXOBMSA-N 0.000 description 1
102400001047 Endostatin Human genes 0.000 description 1
108010079505 Endostatins Proteins 0.000 description 1
YQYJSBFKSSDGFO-UHFFFAOYSA-N Epihygromycin Natural products OC1C(O)C(C(=O)C)OC1OC(C(=C1)O)=CC=C1C=C(C)C(=O)NC1C(O)C(O)C2OCOC2C1O YQYJSBFKSSDGFO-UHFFFAOYSA-N 0.000 description 1
241000283073 Equus caballus Species 0.000 description 1
241000701959 Escherichia virus Lambda Species 0.000 description 1
108010074860 Factor Xa Proteins 0.000 description 1
BJGNCJDXODQBOB-UHFFFAOYSA-N Fivefly Luciferin Natural products OC(=O)C1CSC(C=2SC3=CC(O)=CC=C3N=2)=N1 BJGNCJDXODQBOB-UHFFFAOYSA-N 0.000 description 1
GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 1
241000287828 Gallus gallus Species 0.000 description 1
108700028146 Genetic Enhancer Elements Proteins 0.000 description 1
108010051815 Glutamyl endopeptidase Proteins 0.000 description 1
SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
108010024636 Glutathione Proteins 0.000 description 1
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 1
239000004471 Glycine Substances 0.000 description 1
208000024869 Goodpasture syndrome Diseases 0.000 description 1
108010026389 Gramicidin Proteins 0.000 description 1
208000015023 Graves' disease Diseases 0.000 description 1
208000035895 Guillain-Barré syndrome Diseases 0.000 description 1
206010019755 Hepatitis chronic active Diseases 0.000 description 1
102000010029 Homer Scaffolding Proteins Human genes 0.000 description 1
108010077223 Homer Scaffolding Proteins Proteins 0.000 description 1
101000678879 Homo sapiens Atypical chemokine receptor 1 Proteins 0.000 description 1
101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 description 1
101000914511 Homo sapiens CD27 antigen Proteins 0.000 description 1
101000721661 Homo sapiens Cellular tumor antigen p53 Proteins 0.000 description 1
101000743767 Homo sapiens Coiled-coil domain-containing protein R3HCC1L Proteins 0.000 description 1
101100369992 Homo sapiens TNFSF10 gene Proteins 0.000 description 1
101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 description 1
101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 description 1
101001074035 Homo sapiens Zinc finger protein GLI2 Proteins 0.000 description 1
241000700588 Human alphaherpesvirus 1 Species 0.000 description 1
241000701024 Human betaherpesvirus 5 Species 0.000 description 1
PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 description 1
206010020751 Hypersensitivity Diseases 0.000 description 1
108010091358 Hypoxanthine Phosphoribosyltransferase Proteins 0.000 description 1
102100029098 Hypoxanthine-guanine phosphoribosyltransferase Human genes 0.000 description 1
208000034174 Immunodeficiency by defective expression of MHC class II Diseases 0.000 description 1
108010067060 Immunoglobulin Variable Region Proteins 0.000 description 1
102000017727 Immunoglobulin Variable Region Human genes 0.000 description 1
102000055031 Inhibitor of Apoptosis Proteins Human genes 0.000 description 1
108020005350 Initiator Codon Proteins 0.000 description 1
206010022489 Insulin Resistance Diseases 0.000 description 1
102000010789 Interleukin-2 Receptors Human genes 0.000 description 1
108010038453 Interleukin-2 Receptors Proteins 0.000 description 1
108010002386 Interleukin-3 Proteins 0.000 description 1
108010002586 Interleukin-7 Proteins 0.000 description 1
102000015696 Interleukins Human genes 0.000 description 1
108010063738 Interleukins Proteins 0.000 description 1
108700013992 Kappa-Chain Deficiency Proteins 0.000 description 1
SNDPXSYFESPGGJ-BYPYZUCNSA-N L-2-aminopentanoic acid Chemical compound CCC[C@H](N)C(O)=O SNDPXSYFESPGGJ-BYPYZUCNSA-N 0.000 description 1
AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 description 1
QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
ZGUNAGUHMKGQNY-ZETCQYMHSA-N L-alpha-phenylglycine zwitterion Chemical compound OC(=O)[C@@H](N)C1=CC=CC=C1 ZGUNAGUHMKGQNY-ZETCQYMHSA-N 0.000 description 1
ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 description 1
XIGSAGMEBXLVJJ-YFKPBYRVSA-N L-homocitrulline Chemical compound NC(=O)NCCCC[C@H]([NH3+])C([O-])=O XIGSAGMEBXLVJJ-YFKPBYRVSA-N 0.000 description 1
AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 1
SNDPXSYFESPGGJ-UHFFFAOYSA-N L-norVal-OH Natural products CCCC(N)C(O)=O SNDPXSYFESPGGJ-UHFFFAOYSA-N 0.000 description 1
LRQKBLKVPFOOQJ-YFKPBYRVSA-N L-norleucine Chemical compound CCCC[C@H]([NH3+])C([O-])=O LRQKBLKVPFOOQJ-YFKPBYRVSA-N 0.000 description 1
QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
108090001090 Lectins Proteins 0.000 description 1
102000004856 Lectins Human genes 0.000 description 1
NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 1
108060001084 Luciferase Proteins 0.000 description 1
239000005089 Luciferase Substances 0.000 description 1
DDWFXDSYGUXRAY-UHFFFAOYSA-N Luciferin Natural products CCc1c(C)c(CC2NC(=O)C(=C2C=C)C)[nH]c1Cc3[nH]c4C(=C5/NC(CC(=O)O)C(C)C5CC(=O)O)CC(=O)c4c3C DDWFXDSYGUXRAY-UHFFFAOYSA-N 0.000 description 1
206010058467 Lung neoplasm malignant Diseases 0.000 description 1
102000004083 Lymphotoxin-alpha Human genes 0.000 description 1
108090000542 Lymphotoxin-alpha Proteins 0.000 description 1
102100037611 Lysophospholipase Human genes 0.000 description 1
102000043129 MHC class I family Human genes 0.000 description 1
108091054437 MHC class I family Proteins 0.000 description 1
201000009635 MHC class II deficiency Diseases 0.000 description 1
102000043131 MHC class II family Human genes 0.000 description 1
108091054438 MHC class II family Proteins 0.000 description 1
108010037274 Member 9 Tumor Necrosis Factor Receptor Superfamily Proteins 0.000 description 1
102000011769 Member 9 Tumor Necrosis Factor Receptor Superfamily Human genes 0.000 description 1
208000004451 Membranoproliferative Glomerulonephritis Diseases 0.000 description 1
102000003792 Metallothionein Human genes 0.000 description 1
108090000157 Metallothionein Proteins 0.000 description 1
206010049567 Miller Fisher syndrome Diseases 0.000 description 1
VFKZTMPDYBFSTM-KVTDHHQDSA-N Mitobronitol Chemical compound BrC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CBr VFKZTMPDYBFSTM-KVTDHHQDSA-N 0.000 description 1
229930192392 Mitomycin Natural products 0.000 description 1
208000003250 Mixed connective tissue disease Diseases 0.000 description 1
208000009525 Myocarditis Diseases 0.000 description 1
201000002481 Myositis Diseases 0.000 description 1
238000005481 NMR spectroscopy Methods 0.000 description 1
108091061960 Naked DNA Proteins 0.000 description 1
241001602876 Nata Species 0.000 description 1
RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 description 1
229930193140 Neomycin Natural products 0.000 description 1
208000009567 Neonatal Alloimmune Thrombocytopenia Diseases 0.000 description 1
108010025020 Nerve Growth Factor Proteins 0.000 description 1
206010029240 Neuritis Diseases 0.000 description 1
201000008962 Nezelof syndrome Diseases 0.000 description 1
239000000020 Nitrocellulose Substances 0.000 description 1
108020005187 Oligonucleotide Probes Proteins 0.000 description 1
AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 description 1
UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 description 1
101710160107 Outer membrane protein A Proteins 0.000 description 1
238000012408 PCR amplification Methods 0.000 description 1
101150075130 PNOC gene Proteins 0.000 description 1
239000002033 PVDF binder Substances 0.000 description 1
241000282579 Pan Species 0.000 description 1
206010061902 Pancreatic neoplasm Diseases 0.000 description 1
241000282520 Papio Species 0.000 description 1
241000237988 Patellidae Species 0.000 description 1
241001494479 Pecora Species 0.000 description 1
206010034277 Pemphigoid Diseases 0.000 description 1
201000011152 Pemphigus Diseases 0.000 description 1
241000721454 Pemphigus Species 0.000 description 1
229930182555 Penicillin Natural products 0.000 description 1
JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
108091005804 Peptidases Proteins 0.000 description 1
102000035195 Peptidases Human genes 0.000 description 1
208000031845 Pernicious anaemia Diseases 0.000 description 1
108010058864 Phospholipases A2 Proteins 0.000 description 1
102000045595 Phosphoprotein Phosphatases Human genes 0.000 description 1
108700019535 Phosphoprotein Phosphatases Proteins 0.000 description 1
108010004729 Phycoerythrin Proteins 0.000 description 1
108010001014 Plasminogen Activators Proteins 0.000 description 1
102000001938 Plasminogen Activators Human genes 0.000 description 1
108010038512 Platelet-Derived Growth Factor Proteins 0.000 description 1
102000010780 Platelet-Derived Growth Factor Human genes 0.000 description 1
206010035664 Pneumonia Diseases 0.000 description 1
241000276498 Pollachius virens Species 0.000 description 1
206010065159 Polychondritis Diseases 0.000 description 1
208000025237 Polyendocrinopathy Diseases 0.000 description 1
239000004743 Polypropylene Substances 0.000 description 1
229920001213 Polysorbate 20 Polymers 0.000 description 1
239000004793 Polystyrene Substances 0.000 description 1
239000004372 Polyvinyl alcohol Substances 0.000 description 1
208000012654 Primary biliary cholangitis Diseases 0.000 description 1
102000003923 Protein Kinase C Human genes 0.000 description 1
108090000315 Protein Kinase C Proteins 0.000 description 1
101000762949 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) Exotoxin A Proteins 0.000 description 1
239000012083 RIPA buffer Substances 0.000 description 1
108091034057 RNA (poly(A)) Proteins 0.000 description 1
239000012980 RPMI-1640 medium Substances 0.000 description 1
208000033464 Reiter syndrome Diseases 0.000 description 1
201000000582 Retinoblastoma Diseases 0.000 description 1
108010039491 Ricin Proteins 0.000 description 1
101150054830 S100A6 gene Proteins 0.000 description 1
AUVVAXYIELKVAI-UHFFFAOYSA-N SJ000285215 Natural products N1CCC2=CC(OC)=C(OC)C=C2C1CC1CC2C3=CC(OC)=C(OC)C=C3CCN2CC1CC AUVVAXYIELKVAI-UHFFFAOYSA-N 0.000 description 1
241000235070 Saccharomyces Species 0.000 description 1
241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 description 1
108010077895 Sarcosine Proteins 0.000 description 1
108091058545 Secretory proteins Proteins 0.000 description 1
102000040739 Secretory proteins Human genes 0.000 description 1
206010057863 Selective IgG subclass deficiency Diseases 0.000 description 1
206010039916 Selective IgM immunodeficiency Diseases 0.000 description 1
108091081021 Sense strand Proteins 0.000 description 1
208000009642 Severe combined immunodeficiency due to adenosine deaminase deficiency Diseases 0.000 description 1
241000700584 Simplexvirus Species 0.000 description 1
108020004682 Single-Stranded DNA Proteins 0.000 description 1
208000021386 Sjogren Syndrome Diseases 0.000 description 1
102220497176 Small vasohibin-binding protein_T47D_mutation Human genes 0.000 description 1
238000002105 Southern blotting Methods 0.000 description 1
102000011971 Sphingomyelin Phosphodiesterase Human genes 0.000 description 1
108010061312 Sphingomyelin Phosphodiesterase Proteins 0.000 description 1
241000256248 Spodoptera Species 0.000 description 1
241000256251 Spodoptera frugiperda Species 0.000 description 1
206010072148 Stiff-Person syndrome Diseases 0.000 description 1
108010090804 Streptavidin Proteins 0.000 description 1
241000187747 Streptomyces Species 0.000 description 1
ZSJLQEPLLKMAKR-UHFFFAOYSA-N Streptozotocin Natural products O=NN(C)C(=O)NC1C(O)OC(CO)C(O)C1O ZSJLQEPLLKMAKR-UHFFFAOYSA-N 0.000 description 1
241000282887 Suidae Species 0.000 description 1
102000019197 Superoxide Dismutase Human genes 0.000 description 1
108010012715 Superoxide dismutase Proteins 0.000 description 1
230000006052 T cell proliferation Effects 0.000 description 1
108700012920 TNF Proteins 0.000 description 1
108700012411 TNFSF10 Proteins 0.000 description 1
108020005038 Terminator Codon Proteins 0.000 description 1
239000004098 Tetracycline Substances 0.000 description 1
241000011102 Thera Species 0.000 description 1
108010022394 Threonine synthase Proteins 0.000 description 1
108090000190 Thrombin Proteins 0.000 description 1
208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 description 1
208000002715 Thymic aplasia Diseases 0.000 description 1
102000006601 Thymidine Kinase Human genes 0.000 description 1
108020004440 Thymidine kinase Proteins 0.000 description 1
101710120037 Toxin CcdB Proteins 0.000 description 1
108090000631 Trypsin Proteins 0.000 description 1
102000004142 Trypsin Human genes 0.000 description 1
QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
102100024598 Tumor necrosis factor ligand superfamily member 10 Human genes 0.000 description 1
101710187830 Tumor necrosis factor receptor superfamily member 1B Proteins 0.000 description 1
102100033733 Tumor necrosis factor receptor superfamily member 1B Human genes 0.000 description 1
101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 description 1
102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 description 1
102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 description 1
YJQCOFNZVFGCAF-UHFFFAOYSA-N Tunicamycin II Natural products O1C(CC(O)C2C(C(O)C(O2)N2C(NC(=O)C=C2)=O)O)C(O)C(O)C(NC(=O)C=CCCCCCCCCC(C)C)C1OC1OC(CO)C(O)C(O)C1NC(C)=O YJQCOFNZVFGCAF-UHFFFAOYSA-N 0.000 description 1
206010067584 Type 1 diabetes mellitus Diseases 0.000 description 1
GBOGMAARMMDZGR-UHFFFAOYSA-N UNPD149280 Natural products N1C(=O)C23OC(=O)C=CC(O)CCCC(C)CC=CC3C(O)C(=C)C(C)C2C1CC1=CC=CC=C1 GBOGMAARMMDZGR-UHFFFAOYSA-N 0.000 description 1
201000006704 Ulcerative Colitis Diseases 0.000 description 1
229910052770 Uranium Inorganic materials 0.000 description 1
208000024780 Urticaria Diseases 0.000 description 1
206010046851 Uveitis Diseases 0.000 description 1
206010046865 Vaccinia virus infection Diseases 0.000 description 1
KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
206010047115 Vasculitis Diseases 0.000 description 1
241000251539 Vertebrata <Metazoa> Species 0.000 description 1
206010047642 Vitiligo Diseases 0.000 description 1
102100035558 Zinc finger protein GLI2 Human genes 0.000 description 1
230000002159 abnormal effect Effects 0.000 description 1
229940022698 acetylcholinesterase Drugs 0.000 description 1
230000002378 acidificating effect Effects 0.000 description 1
229930183665 actinomycin Natural products 0.000 description 1
239000013543 active substance Substances 0.000 description 1
239000000654 additive Substances 0.000 description 1
230000000996 additive effect Effects 0.000 description 1
229960000643 adenine Drugs 0.000 description 1
201000009628 adenosine deaminase deficiency Diseases 0.000 description 1
210000001789 adipocyte Anatomy 0.000 description 1
239000007801 affinity label Substances 0.000 description 1
235000004279 alanine Nutrition 0.000 description 1
229940100198 alkylating agent Drugs 0.000 description 1
239000002168 alkylating agent Substances 0.000 description 1
SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 1
208000026935 allergic disease Diseases 0.000 description 1
230000007815 allergy Effects 0.000 description 1
WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
229960002684 aminocaproic acid Drugs 0.000 description 1
229940126575 aminoglycoside Drugs 0.000 description 1
BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
229910052921 ammonium sulfate Inorganic materials 0.000 description 1
238000012870 ammonium sulfate precipitation Methods 0.000 description 1
235000011130 ammonium sulphate Nutrition 0.000 description 1
229960000723 ampicillin Drugs 0.000 description 1
AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 1
239000004037 angiogenesis inhibitor Substances 0.000 description 1
210000004102 animal cell Anatomy 0.000 description 1
238000010171 animal model Methods 0.000 description 1
238000005571 anion exchange chromatography Methods 0.000 description 1
150000001450 anions Chemical class 0.000 description 1
238000000137 annealing Methods 0.000 description 1
MWPLVEDNUUSJAV-UHFFFAOYSA-N anthracene Chemical compound C1=CC=CC2=CC3=CC=CC=C3C=C21 MWPLVEDNUUSJAV-UHFFFAOYSA-N 0.000 description 1
229940045799 anthracyclines and related substance Drugs 0.000 description 1
230000003367 anti-collagen effect Effects 0.000 description 1
230000000692 anti-sense effect Effects 0.000 description 1
230000000259 anti-tumor effect Effects 0.000 description 1
229940088710 antibiotic agent Drugs 0.000 description 1
238000011230 antibody-based therapy Methods 0.000 description 1
239000003080 antimitotic agent Substances 0.000 description 1
229960004405 aprotinin Drugs 0.000 description 1
108010062796 arginyllysine Proteins 0.000 description 1
125000003118 aryl group Chemical group 0.000 description 1
FZCSTZYAHCUGEM-UHFFFAOYSA-N aspergillomarasmine B Natural products OC(=O)CNC(C(O)=O)CNC(C(O)=O)CC(O)=O FZCSTZYAHCUGEM-UHFFFAOYSA-N 0.000 description 1
201000008937 atopic dermatitis Diseases 0.000 description 1
230000005784 autoimmunity Effects 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 1
238000004166 bioassay Methods 0.000 description 1
230000008512 biological response Effects 0.000 description 1
238000001815 biotherapy Methods 0.000 description 1
210000000601 blood cell Anatomy 0.000 description 1
210000002798 bone marrow cell Anatomy 0.000 description 1
208000000594 bullous pemphigoid Diseases 0.000 description 1
229960002092 busulfan Drugs 0.000 description 1
235000014633 carbohydrates Nutrition 0.000 description 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
239000008112 carboxymethyl-cellulose Substances 0.000 description 1
229960005243 carmustine Drugs 0.000 description 1
238000005277 cation exchange chromatography Methods 0.000 description 1
210000000170 cell membrane Anatomy 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
238000005119 centrifugation Methods 0.000 description 1
230000008859 change Effects 0.000 description 1
NDAYQJDHGXTBJL-MWWSRJDJSA-N chembl557217 Chemical compound C1=CC=C2C(C[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC=3C4=CC=CC=C4NC=3)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC=3C4=CC=CC=C4NC=3)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC=3C4=CC=CC=C4NC=3)NC(=O)[C@@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](NC=O)C(C)C)CC(C)C)C(=O)NCCO)=CNC2=C1 NDAYQJDHGXTBJL-MWWSRJDJSA-N 0.000 description 1
238000001311 chemical methods and process Methods 0.000 description 1
239000003153 chemical reaction reagent Substances 0.000 description 1
235000013330 chicken meat Nutrition 0.000 description 1
JCKYGMPEJWAADB-UHFFFAOYSA-N chlorambucil Chemical compound OC(=O)CCCC1=CC=C(N(CCCl)CCCl)C=C1 JCKYGMPEJWAADB-UHFFFAOYSA-N 0.000 description 1
229960004630 chlorambucil Drugs 0.000 description 1
208000025302 chronic primary adrenal insufficiency Diseases 0.000 description 1
229960002376 chymotrypsin Drugs 0.000 description 1
229960004316 cisplatin Drugs 0.000 description 1
229960002173 citrulline Drugs 0.000 description 1
235000013477 citrulline Nutrition 0.000 description 1
238000000975 co-precipitation Methods 0.000 description 1
208000029742 colonic neoplasm Diseases 0.000 description 1
238000004440 column chromatography Methods 0.000 description 1
230000009137 competitive binding Effects 0.000 description 1
208000029192 congenital agammaglobulinemia Diseases 0.000 description 1
238000010276 construction Methods 0.000 description 1
239000000599 controlled substance Substances 0.000 description 1
229920001577 copolymer Polymers 0.000 description 1
238000004132 cross linking Methods 0.000 description 1
238000002425 crystallisation Methods 0.000 description 1
230000008025 crystallization Effects 0.000 description 1
239000012228 culture supernatant Substances 0.000 description 1
ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 description 1
229960000684 cytarabine Drugs 0.000 description 1
GBOGMAARMMDZGR-TYHYBEHESA-N cytochalasin B Chemical compound C([C@H]1[C@@H]2[C@@H](C([C@@H](O)[C@@H]3/C=C/C[C@H](C)CCC[C@@H](O)/C=C/C(=O)O[C@@]23C(=O)N1)=C)C)C1=CC=CC=C1 GBOGMAARMMDZGR-TYHYBEHESA-N 0.000 description 1
GBOGMAARMMDZGR-JREHFAHYSA-N cytochalasin B Natural products C[C@H]1CCC[C@@H](O)C=CC(=O)O[C@@]23[C@H](C=CC1)[C@H](O)C(=C)[C@@H](C)[C@@H]2[C@H](Cc4ccccc4)NC3=O GBOGMAARMMDZGR-JREHFAHYSA-N 0.000 description 1
231100000409 cytocidal Toxicity 0.000 description 1
230000000445 cytocidal effect Effects 0.000 description 1
229940104302 cytosine Drugs 0.000 description 1
230000001086 cytosolic effect Effects 0.000 description 1
239000000824 cytostatic agent Substances 0.000 description 1
230000001085 cytostatic effect Effects 0.000 description 1
230000001472 cytotoxic effect Effects 0.000 description 1
239000003145 cytotoxic factor Substances 0.000 description 1
230000007812 deficiency Effects 0.000 description 1
230000002950 deficient Effects 0.000 description 1
230000003412 degenerative effect Effects 0.000 description 1
208000022401 dense deposit disease Diseases 0.000 description 1
KXGVEGMKQFWNSR-LLQZFEROSA-N deoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 KXGVEGMKQFWNSR-LLQZFEROSA-N 0.000 description 1
229960003964 deoxycholic acid Drugs 0.000 description 1
201000001981 dermatomyositis Diseases 0.000 description 1
230000001627 detrimental effect Effects 0.000 description 1
229960000633 dextran sulfate Drugs 0.000 description 1
239000000032 diagnostic agent Substances 0.000 description 1
229940039227 diagnostic agent Drugs 0.000 description 1
102000004419 dihydrofolate reductase Human genes 0.000 description 1
238000010790 dilution Methods 0.000 description 1
239000012895 dilution Substances 0.000 description 1
XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 description 1
229960002986 dinoprostone Drugs 0.000 description 1
229940042399 direct acting antivirals protease inhibitors Drugs 0.000 description 1
230000006806 disease prevention Effects 0.000 description 1
PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 description 1
230000002222 downregulating effect Effects 0.000 description 1
230000008482 dysregulation Effects 0.000 description 1
238000001962 electrophoresis Methods 0.000 description 1
AUVVAXYIELKVAI-CKBKHPSWSA-N emetine Chemical compound N1CCC2=CC(OC)=C(OC)C=C2[C@H]1C[C@H]1C[C@H]2C3=CC(OC)=C(OC)C=C3CCN2C[C@@H]1CC AUVVAXYIELKVAI-CKBKHPSWSA-N 0.000 description 1
229960002694 emetine Drugs 0.000 description 1
AUVVAXYIELKVAI-UWBTVBNJSA-N emetine Natural products N1CCC2=CC(OC)=C(OC)C=C2[C@H]1C[C@H]1C[C@H]2C3=CC(OC)=C(OC)C=C3CCN2C[C@H]1CC AUVVAXYIELKVAI-UWBTVBNJSA-N 0.000 description 1
210000003372 endocrine gland Anatomy 0.000 description 1
206010014801 endophthalmitis Diseases 0.000 description 1
238000012869 ethanol precipitation Methods 0.000 description 1
ZMMJGEGLRURXTF-UHFFFAOYSA-N ethidium bromide Chemical compound [Br-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CC)=C1C1=CC=CC=C1 ZMMJGEGLRURXTF-UHFFFAOYSA-N 0.000 description 1
229960005542 ethidium bromide Drugs 0.000 description 1
229960005420 etoposide Drugs 0.000 description 1
VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 description 1
238000011156 evaluation Methods 0.000 description 1
230000007717 exclusion Effects 0.000 description 1
230000029142 excretion Effects 0.000 description 1
239000000284 extract Substances 0.000 description 1
238000000605 extraction Methods 0.000 description 1
108010052621 fas Receptor Proteins 0.000 description 1
102000018823 fas Receptor Human genes 0.000 description 1
235000013861 fat-free Nutrition 0.000 description 1
239000012091 fetal bovine serum Substances 0.000 description 1
230000001605 fetal effect Effects 0.000 description 1
210000002458 fetal heart Anatomy 0.000 description 1
235000019688 fish Nutrition 0.000 description 1
MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 1
229960002949 fluorouracil Drugs 0.000 description 1
201000003444 follicular lymphoma Diseases 0.000 description 1
230000037433 frameshift Effects 0.000 description 1
230000002538 fungal effect Effects 0.000 description 1
ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 1
229910052733 gallium Inorganic materials 0.000 description 1
229960003692 gamma aminobutyric acid Drugs 0.000 description 1
238000005227 gel permeation chromatography Methods 0.000 description 1
238000002523 gelfiltration Methods 0.000 description 1
238000001415 gene therapy Methods 0.000 description 1
238000007429 general method Methods 0.000 description 1
238000010353 genetic engineering Methods 0.000 description 1
238000010362 genome editing Methods 0.000 description 1
210000004602 germ cell Anatomy 0.000 description 1
239000011521 glass Substances 0.000 description 1
208000005017 glioblastoma Diseases 0.000 description 1
239000003862 glucocorticoid Substances 0.000 description 1
125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 description 1
229960003180 glutathione Drugs 0.000 description 1
150000002334 glycols Chemical class 0.000 description 1
PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
210000003714 granulocyte Anatomy 0.000 description 1
230000009036 growth inhibition Effects 0.000 description 1
230000035931 haemagglutination Effects 0.000 description 1
210000004524 haematopoietic cell Anatomy 0.000 description 1
230000003394 haemopoietic effect Effects 0.000 description 1
210000002216 heart Anatomy 0.000 description 1
208000024348 heart neoplasm Diseases 0.000 description 1
239000000185 hemagglutinin Substances 0.000 description 1
108060003552 hemocyanin Proteins 0.000 description 1
208000007475 hemolytic anemia Diseases 0.000 description 1
238000004128 high performance liquid chromatography Methods 0.000 description 1
125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 description 1
239000012456 homogeneous solution Substances 0.000 description 1
229940088597 hormone Drugs 0.000 description 1
239000005556 hormone Substances 0.000 description 1
238000001794 hormone therapy Methods 0.000 description 1
230000005745 host immune response Effects 0.000 description 1
102000057041 human TNF Human genes 0.000 description 1
210000003917 human chromosome Anatomy 0.000 description 1
238000004191 hydrophobic interaction chromatography Methods 0.000 description 1
238000012872 hydroxylapatite chromatography Methods 0.000 description 1
229960002591 hydroxyproline Drugs 0.000 description 1
206010066130 hyper-IgM syndrome Diseases 0.000 description 1
208000003532 hypothyroidism Diseases 0.000 description 1
230000002989 hypothyroidism Effects 0.000 description 1
229940127121 immunoconjugate Drugs 0.000 description 1
238000000760 immunoelectrophoresis Methods 0.000 description 1
238000010166 immunofluorescence Methods 0.000 description 1
230000016784 immunoglobulin production Effects 0.000 description 1
239000000367 immunologic factor Substances 0.000 description 1
239000012133 immunoprecipitate Substances 0.000 description 1
238000009169 immunotherapy Methods 0.000 description 1
239000002596 immunotoxin Substances 0.000 description 1
238000011065 in-situ storage Methods 0.000 description 1
230000000415 inactivating effect Effects 0.000 description 1
230000002779 inactivation Effects 0.000 description 1
238000009399 inbreeding Methods 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
208000000509 infertility Diseases 0.000 description 1
230000036512 infertility Effects 0.000 description 1
231100000535 infertility Toxicity 0.000 description 1
239000003112 inhibitor Substances 0.000 description 1
ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
229940100601 interleukin-6 Drugs 0.000 description 1
229940047122 interleukins Drugs 0.000 description 1
238000007912 intraperitoneal administration Methods 0.000 description 1
238000005342 ion exchange Methods 0.000 description 1
238000002955 isolation Methods 0.000 description 1
229960000310 isoleucine Drugs 0.000 description 1
AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
230000000155 isotopic effect Effects 0.000 description 1
108010045069 keyhole-limpet hemocyanin Proteins 0.000 description 1
210000003734 kidney Anatomy 0.000 description 1
238000002372 labelling Methods 0.000 description 1
239000002523 lectin Substances 0.000 description 1
201000002364 leukopenia Diseases 0.000 description 1
231100001022 leukopenia Toxicity 0.000 description 1
229960004194 lidocaine Drugs 0.000 description 1
150000002632 lipids Chemical class 0.000 description 1
210000004185 liver Anatomy 0.000 description 1
229960002247 lomustine Drugs 0.000 description 1
230000007774 longterm Effects 0.000 description 1
HWYHZTIRURJOHG-UHFFFAOYSA-N luminol Chemical compound O=C1NNC(=O)C2=C1C(N)=CC=C2 HWYHZTIRURJOHG-UHFFFAOYSA-N 0.000 description 1
201000005202 lung cancer Diseases 0.000 description 1
210000001165 lymph node Anatomy 0.000 description 1
230000001926 lymphatic effect Effects 0.000 description 1
201000001268 lymphoproliferative syndrome Diseases 0.000 description 1
230000002934 lysing effect Effects 0.000 description 1
210000002540 macrophage Anatomy 0.000 description 1
208000015486 malignant pancreatic neoplasm Diseases 0.000 description 1
210000005075 mammary gland Anatomy 0.000 description 1
238000013507 mapping Methods 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
HAWPXGHAZFHHAD-UHFFFAOYSA-N mechlorethamine Chemical compound ClCCN(C)CCCl HAWPXGHAZFHHAD-UHFFFAOYSA-N 0.000 description 1
229960004961 mechlorethamine Drugs 0.000 description 1
SGDBTWWWUNNDEQ-LBPRGKRZSA-N melphalan Chemical compound OC(=O)[C@@H](N)CC1=CC=C(N(CCCl)CCCl)C=C1 SGDBTWWWUNNDEQ-LBPRGKRZSA-N 0.000 description 1
229960001924 melphalan Drugs 0.000 description 1
229960001428 mercaptopurine Drugs 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
150000002739 metals Chemical class 0.000 description 1
230000031864 metaphase Effects 0.000 description 1
HPNSFSBZBAHARI-UHFFFAOYSA-N micophenolic acid Natural products OC1=C(CC=C(C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-UHFFFAOYSA-N 0.000 description 1
244000005700 microbiome Species 0.000 description 1
238000000520 microinjection Methods 0.000 description 1
235000013336 milk Nutrition 0.000 description 1
239000008267 milk Substances 0.000 description 1
210000004080 milk Anatomy 0.000 description 1
239000011707 mineral Substances 0.000 description 1
229960005485 mitobronitol Drugs 0.000 description 1
KKZJGLLVHKMTCM-UHFFFAOYSA-N mitoxantrone Chemical compound O=C1C2=C(O)C=CC(O)=C2C(=O)C2=C1C(NCCNCCO)=CC=C2NCCNCCO KKZJGLLVHKMTCM-UHFFFAOYSA-N 0.000 description 1
229960001156 mitoxantrone Drugs 0.000 description 1
102000035118 modified proteins Human genes 0.000 description 1
108091005573 modified proteins Proteins 0.000 description 1
238000010369 molecular cloning Methods 0.000 description 1
239000002808 molecular sieve Substances 0.000 description 1
238000012544 monitoring process Methods 0.000 description 1
201000006417 multiple sclerosis Diseases 0.000 description 1
210000003205 muscle Anatomy 0.000 description 1
210000000663 muscle cell Anatomy 0.000 description 1
206010028417 myasthenia gravis Diseases 0.000 description 1
229960000951 mycophenolic acid Drugs 0.000 description 1
HPNSFSBZBAHARI-RUDMXATFSA-N mycophenolic acid Chemical compound OC1=C(C\C=C(/C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-RUDMXATFSA-N 0.000 description 1
208000010125 myocardial infarction Diseases 0.000 description 1
108010058605 myotrophin Proteins 0.000 description 1
102000006392 myotrophin Human genes 0.000 description 1
ZTLGJPIZUOVDMT-UHFFFAOYSA-N n,n-dichlorotriazin-4-amine Chemical compound ClN(Cl)C1=CC=NN=N1 ZTLGJPIZUOVDMT-UHFFFAOYSA-N 0.000 description 1
230000021766 negative regulation of B cell proliferation Effects 0.000 description 1
229960004927 neomycin Drugs 0.000 description 1
208000030372 neonatal thrombocytopenia Diseases 0.000 description 1
229940053128 nerve growth factor Drugs 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
208000004235 neutropenia Diseases 0.000 description 1
229920001220 nitrocellulos Polymers 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
230000009871 nonspecific binding Effects 0.000 description 1
125000003835 nucleoside group Chemical group 0.000 description 1
210000004940 nucleus Anatomy 0.000 description 1
239000003921 oil Substances 0.000 description 1
235000019198 oils Nutrition 0.000 description 1
239000002751 oligonucleotide probe Substances 0.000 description 1
210000000287 oocyte Anatomy 0.000 description 1
238000005457 optimization Methods 0.000 description 1
229960003104 ornithine Drugs 0.000 description 1
238000009400 out breeding Methods 0.000 description 1
230000003647 oxidation Effects 0.000 description 1
238000007254 oxidation reaction Methods 0.000 description 1
238000004806 packaging method and process Methods 0.000 description 1
210000002741 palatine tonsil Anatomy 0.000 description 1
201000002528 pancreatic cancer Diseases 0.000 description 1
208000008443 pancreatic carcinoma Diseases 0.000 description 1
230000005298 paramagnetic effect Effects 0.000 description 1
230000036961 partial effect Effects 0.000 description 1
230000001717 pathogenic effect Effects 0.000 description 1
230000007170 pathology Effects 0.000 description 1
201000001976 pemphigus vulgaris Diseases 0.000 description 1
229940049954 penicillin Drugs 0.000 description 1
239000000137 peptide hydrolase inhibitor Substances 0.000 description 1
238000010647 peptide synthesis reaction Methods 0.000 description 1
230000002688 persistence Effects 0.000 description 1
239000012071 phase Substances 0.000 description 1
108010073128 phosphatidylcholine-specific phospholipase C Proteins 0.000 description 1
229940080469 phosphocellulose Drugs 0.000 description 1
239000003934 phosphoprotein phosphatase inhibitor Substances 0.000 description 1
230000008288 physiological mechanism Effects 0.000 description 1
230000006461 physiological response Effects 0.000 description 1
210000002826 placenta Anatomy 0.000 description 1
239000013600 plasmid vector Substances 0.000 description 1
229940127126 plasminogen activator Drugs 0.000 description 1
230000004983 pleiotropic effect Effects 0.000 description 1
229920001983 poloxamer Polymers 0.000 description 1
229920000447 polyanionic polymer Polymers 0.000 description 1
208000005987 polymyositis Diseases 0.000 description 1
229920005862 polyol Polymers 0.000 description 1
150000003077 polyols Chemical class 0.000 description 1
239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
229920001155 polypropylene Polymers 0.000 description 1
229920002223 polystyrene Polymers 0.000 description 1
229920002451 polyvinyl alcohol Polymers 0.000 description 1
229920000915 polyvinyl chloride Polymers 0.000 description 1
239000004800 polyvinyl chloride Substances 0.000 description 1
229920002981 polyvinylidene fluoride Polymers 0.000 description 1
235000020004 porter Nutrition 0.000 description 1
238000002600 positron emission tomography Methods 0.000 description 1
230000004481 post-translational protein modification Effects 0.000 description 1
230000001323 posttranslational effect Effects 0.000 description 1
239000002243 precursor Substances 0.000 description 1
230000002265 prevention Effects 0.000 description 1
229960004919 procaine Drugs 0.000 description 1
MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
238000004393 prognosis Methods 0.000 description 1
230000002062 proliferating effect Effects 0.000 description 1
238000011321 prophylaxis Methods 0.000 description 1
229960003712 propranolol Drugs 0.000 description 1
XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 description 1
210000002307 prostate Anatomy 0.000 description 1
238000013197 protein A assay Methods 0.000 description 1
230000004952 protein activity Effects 0.000 description 1
235000004252 protein component Nutrition 0.000 description 1
230000004853 protein function Effects 0.000 description 1
230000009145 protein modification Effects 0.000 description 1
239000012264 purified product Substances 0.000 description 1
229950010131 puromycin Drugs 0.000 description 1
238000001959 radiotherapy Methods 0.000 description 1
238000002708 random mutagenesis Methods 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
208000002574 reactive arthritis Diseases 0.000 description 1
239000000018 receptor agonist Substances 0.000 description 1
229940044601 receptor agonist Drugs 0.000 description 1
239000002464 receptor antagonist Substances 0.000 description 1
229940044551 receptor antagonist Drugs 0.000 description 1
208000028641 recurrent infections associated with rare immunoglobulin isotypes deficiency Diseases 0.000 description 1
238000005932 reductive alkylation reaction Methods 0.000 description 1
230000002829 reductive effect Effects 0.000 description 1
230000018866 regulation of programmed cell death Effects 0.000 description 1
208000009169 relapsing polychondritis Diseases 0.000 description 1
230000010076 replication Effects 0.000 description 1
201000007153 reticular dysgenesis Diseases 0.000 description 1
229930002330 retinoic acid Natural products 0.000 description 1
230000001177 retroviral effect Effects 0.000 description 1
230000002441 reversible effect Effects 0.000 description 1
208000004124 rheumatic heart disease Diseases 0.000 description 1
PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
210000003935 rough endoplasmic reticulum Anatomy 0.000 description 1
235000019515 salmon Nutrition 0.000 description 1
239000012723 sample buffer Substances 0.000 description 1
229940043230 sarcosine Drugs 0.000 description 1
238000007423 screening assay Methods 0.000 description 1
239000006152 selective media Substances 0.000 description 1
125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 1
238000004513 sizing Methods 0.000 description 1
210000003491 skin Anatomy 0.000 description 1
URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
239000012279 sodium borohydride Substances 0.000 description 1
229910000033 sodium borohydride Inorganic materials 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
CMZUMMUJMWNLFH-UHFFFAOYSA-N sodium metavanadate Chemical compound [Na+].[O-][V](=O)=O CMZUMMUJMWNLFH-UHFFFAOYSA-N 0.000 description 1
239000008279 sol Substances 0.000 description 1
238000010532 solid phase synthesis reaction Methods 0.000 description 1
230000037439 somatic mutation Effects 0.000 description 1
108700026239 src Genes Proteins 0.000 description 1
230000010473 stable expression Effects 0.000 description 1
230000004936 stimulating effect Effects 0.000 description 1
238000003860 storage Methods 0.000 description 1
229960005322 streptomycin Drugs 0.000 description 1
229960001052 streptozocin Drugs 0.000 description 1
ZSJLQEPLLKMAKR-GKHCUFPYSA-N streptozocin Chemical compound O=NN(C)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O ZSJLQEPLLKMAKR-GKHCUFPYSA-N 0.000 description 1
238000012916 structural analysis Methods 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
238000013268 sustained release Methods 0.000 description 1
239000012730 sustained-release form Substances 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
208000011580 syndromic disease Diseases 0.000 description 1
210000001179 synovial fluid Anatomy 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
229940037128 systemic glucocorticoids Drugs 0.000 description 1
201000000596 systemic lupus erythematosus Diseases 0.000 description 1
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
NRUKOCRGYNPUPR-QBPJDGROSA-N teniposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@@H](OC[C@H]4O3)C=3SC=CC=3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 NRUKOCRGYNPUPR-QBPJDGROSA-N 0.000 description 1
229960001278 teniposide Drugs 0.000 description 1
238000012956 testing procedure Methods 0.000 description 1
229960000814 tetanus toxoid Drugs 0.000 description 1
229960002372 tetracaine Drugs 0.000 description 1
GKCBAIGFKIBETG-UHFFFAOYSA-N tetracaine Chemical compound CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 GKCBAIGFKIBETG-UHFFFAOYSA-N 0.000 description 1
229960002180 tetracycline Drugs 0.000 description 1
229930101283 tetracycline Natural products 0.000 description 1
235000019364 tetracycline Nutrition 0.000 description 1
150000003522 tetracyclines Chemical class 0.000 description 1
238000011285 therapeutic regimen Methods 0.000 description 1
125000003396 thiol group Chemical group [H]S* 0.000 description 1
229960004072 thrombin Drugs 0.000 description 1
230000001732 thrombotic effect Effects 0.000 description 1
230000002992 thymic effect Effects 0.000 description 1
229940104230 thymidine Drugs 0.000 description 1
229940113082 thymine Drugs 0.000 description 1
208000008732 thymoma Diseases 0.000 description 1
229960003087 tioguanine Drugs 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
230000005026 transcription initiation Effects 0.000 description 1
230000005030 transcription termination Effects 0.000 description 1
230000002103 transcriptional effect Effects 0.000 description 1
230000009466 transformation Effects 0.000 description 1
208000016367 transient hypogammaglobulinemia of infancy Diseases 0.000 description 1
229940108519 trasylol Drugs 0.000 description 1
238000011269 treatment regimen Methods 0.000 description 1
229960001727 tretinoin Drugs 0.000 description 1
HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
229940038773 trisodium citrate Drugs 0.000 description 1
GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
239000012588 trypsin Substances 0.000 description 1
229960001322 trypsin Drugs 0.000 description 1
ZHSGGJXRNHWHRS-VIDYELAYSA-N tunicamycin Chemical compound O([C@H]1[C@@H]([C@H]([C@@H](O)[C@@H](CC(O)[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C(NC(=O)C=C2)=O)O)O1)O)NC(=O)/C=C/CC(C)C)[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1NC(C)=O ZHSGGJXRNHWHRS-VIDYELAYSA-N 0.000 description 1
MEYZYGMYMLNUHJ-UHFFFAOYSA-N tunicamycin Natural products CC(C)CCCCCCCCCC=CC(=O)NC1C(O)C(O)C(CC(O)C2OC(C(O)C2O)N3C=CC(=O)NC3=O)OC1OC4OC(CO)C(O)C(O)C4NC(=O)C MEYZYGMYMLNUHJ-UHFFFAOYSA-N 0.000 description 1
208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
ORHBXUUXSCNDEV-UHFFFAOYSA-N umbelliferone Chemical compound C1=CC(=O)OC2=CC(O)=CC=C21 ORHBXUUXSCNDEV-UHFFFAOYSA-N 0.000 description 1
HFTAFOQKODTIJY-UHFFFAOYSA-N umbelliferone Natural products Cc1cc2C=CC(=O)Oc2cc1OCC=CC(C)(C)O HFTAFOQKODTIJY-UHFFFAOYSA-N 0.000 description 1
241000701366 unidentified nuclear polyhedrosis viruses Species 0.000 description 1
241001515965 unidentified phage Species 0.000 description 1
241001430294 unidentified retrovirus Species 0.000 description 1
208000007089 vaccinia Diseases 0.000 description 1
239000004474 valine Substances 0.000 description 1
230000002792 vascular Effects 0.000 description 1
239000003981 vehicle Substances 0.000 description 1
239000013603 viral vector Substances 0.000 description 1
238000011179 visual inspection Methods 0.000 description 1
229920003169 water-soluble polymer Polymers 0.000 description 1
210000005253 yeast cell Anatomy 0.000 description 1
238000001086 yeast two-hybrid system Methods 0.000 description 1
229910000166 zirconium phosphate Inorganic materials 0.000 description 1