CA2363658A1 - Improved process for the preparation of ramipril - Google Patents

Improved process for the preparation of ramipril Download PDF

Info

Publication number
CA2363658A1
CA2363658A1 CA 2363658 CA2363658A CA2363658A1 CA 2363658 A1 CA2363658 A1 CA 2363658A1 CA 2363658 CA2363658 CA 2363658 CA 2363658 A CA2363658 A CA 2363658A CA 2363658 A1 CA2363658 A1 CA 2363658A1
Authority
CA
Canada
Prior art keywords
ramipril
preparation
improved process
formula
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2363658
Other languages
French (fr)
Other versions
CA2363658C (en
Inventor
Zhi-Xian Wang
Cameron Mcphail
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Apotex Pharmachem Inc
Original Assignee
Brantford Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brantford Chemicals Inc filed Critical Brantford Chemicals Inc
Priority to CA 2363658 priority Critical patent/CA2363658C/en
Priority to US09/990,278 priority patent/US6407262B1/en
Priority to PCT/CA2002/001761 priority patent/WO2003045916A1/en
Priority to AU2002342467A priority patent/AU2002342467A1/en
Publication of CA2363658A1 publication Critical patent/CA2363658A1/en
Application granted granted Critical
Publication of CA2363658C publication Critical patent/CA2363658C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A process for separating diastereomeric mixtures of compounds of formula 1 and formula 2
CA 2363658 2001-11-21 2001-11-21 Improved process for the preparation of ramipril Expired - Fee Related CA2363658C (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA 2363658 CA2363658C (en) 2001-11-21 2001-11-21 Improved process for the preparation of ramipril
US09/990,278 US6407262B1 (en) 2001-11-21 2001-11-23 Process for the preparation of Ramipril
PCT/CA2002/001761 WO2003045916A1 (en) 2001-11-21 2002-11-18 Process for the preparation of ramipril
AU2002342467A AU2002342467A1 (en) 2001-11-21 2002-11-18 Process for the preparation of ramipril

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA 2363658 CA2363658C (en) 2001-11-21 2001-11-21 Improved process for the preparation of ramipril

Publications (2)

Publication Number Publication Date
CA2363658A1 true CA2363658A1 (en) 2003-05-21
CA2363658C CA2363658C (en) 2005-12-13

Family

ID=4170634

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2363658 Expired - Fee Related CA2363658C (en) 2001-11-21 2001-11-21 Improved process for the preparation of ramipril

Country Status (3)

Country Link
AU (1) AU2002342467A1 (en)
CA (1) CA2363658C (en)
WO (1) WO2003045916A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103108865A (en) * 2010-06-03 2013-05-15 弗特克斯药品有限公司 Processes and intermediates

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL367931A1 (en) * 2004-05-12 2005-11-14 Instytut Farmaceutyczny Method for manufacture of 2-[n-[(s)-1- etoxycarbonyl-3-phenyl propyl]-(s)-alanyl] -(1s,3s,5s)-2-azabicyclo [3.3.0] octane-3-carboxylic acid
CZ296860B6 (en) * 2004-06-08 2006-07-12 Zentiva, A. S. Process for preparing ramipril

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA817261B (en) * 1980-10-23 1982-09-29 Schering Corp Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them
CA1341296C (en) * 1981-12-29 2001-09-25 Hansjorg Urbach 2-azabicycloalkane-3-carboxylic acid derivatives, processes for their preparation, agents containing these compounds and their use
DE3315464A1 (en) * 1983-04-28 1984-10-31 Hoechst Ag, 6230 Frankfurt METHOD FOR PRODUCING N-ALKYLATED DIPEPTIDES AND THEIR ESTERS
DE3333454A1 (en) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt METHOD FOR PRODUCING N-ALKYLATED DIPEPTIDES AND THEIR ESTERS

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103108865A (en) * 2010-06-03 2013-05-15 弗特克斯药品有限公司 Processes and intermediates

Also Published As

Publication number Publication date
WO2003045916A1 (en) 2003-06-05
CA2363658C (en) 2005-12-13
AU2002342467A1 (en) 2003-06-10

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20131121