CA2363503C - Procedes de diagnostic et de therapie des maladies des yeux associees aux drusen - Google Patents

Procedes de diagnostic et de therapie des maladies des yeux associees aux drusen Download PDF

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Publication number
CA2363503C
CA2363503C CA002363503A CA2363503A CA2363503C CA 2363503 C CA2363503 C CA 2363503C CA 002363503 A CA002363503 A CA 002363503A CA 2363503 A CA2363503 A CA 2363503A CA 2363503 C CA2363503 C CA 2363503C
Authority
CA
Canada
Prior art keywords
drusen
rpe
cells
cell
gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002363503A
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English (en)
Other versions
CA2363503A1 (fr
Inventor
Gregory S. Hageman
Robert F. Mullins
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Iowa Research Foundation UIRF
Original Assignee
University of Iowa Research Foundation UIRF
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Iowa Research Foundation UIRF filed Critical University of Iowa Research Foundation UIRF
Publication of CA2363503A1 publication Critical patent/CA2363503A1/fr
Application granted granted Critical
Publication of CA2363503C publication Critical patent/CA2363503C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/16—Ophthalmology
    • G01N2800/164—Retinal disorders, e.g. retinopathy

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne des procédés de diagnostic, de prévention et de thérapie des maladies des yeux associées aux drusen.
CA002363503A 1999-03-05 2000-03-06 Procedes de diagnostic et de therapie des maladies des yeux associees aux drusen Expired - Fee Related CA2363503C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12305299P 1999-03-05 1999-03-05
US60/123,052 1999-03-05
US51023000A 2000-02-22 2000-02-22
US09/510,230 2000-02-22
PCT/US2000/005858 WO2000052479A2 (fr) 1999-03-05 2000-03-06 Procedes de diagnostic et de therapie des maladies des yeux associees aux drusen

Publications (2)

Publication Number Publication Date
CA2363503A1 CA2363503A1 (fr) 2000-09-08
CA2363503C true CA2363503C (fr) 2009-03-10

Family

ID=26821176

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002363503A Expired - Fee Related CA2363503C (fr) 1999-03-05 2000-03-06 Procedes de diagnostic et de therapie des maladies des yeux associees aux drusen

Country Status (4)

Country Link
EP (1) EP1161686A2 (fr)
AU (1) AU3395800A (fr)
CA (1) CA2363503C (fr)
WO (1) WO2000052479A2 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US7011952B2 (en) 2000-02-22 2006-03-14 University Of Iowa Research Foundation Diagnostics and therapeutics for macular degeneration-related disorders
EP1287364B1 (fr) 2000-04-29 2008-10-22 University Of Iowa Research Foundation Diagnostic et therapeutique pour des troubles lies a une degenerescence maculaire
US7470659B2 (en) 2001-12-07 2008-12-30 The Regents Of The University Of California Methods to increase reverse cholesterol transport in the retinal pigment epithelium (RPE) and Bruch's membrane (BM)
US20030158112A1 (en) 2002-02-15 2003-08-21 Johns Hopkins University School Of Medicine Selective induction of apoptosis to treat ocular disease
US6986995B2 (en) * 2002-02-28 2006-01-17 Prometheus Laboratories, Inc. Methods of diagnosing liver fibrosis
AU2006214320C1 (en) 2005-02-14 2012-07-05 University Of Iowa Research Foundation Methods and reagents for treatment and diagnosis of age-related macular degeneration
US8088773B2 (en) * 2005-05-12 2012-01-03 The Texas A&M University System Therapeutic compositions and methods
CA2621953A1 (fr) * 2005-09-09 2007-03-22 University Of Iowa Research Foundation Marqueurs biologiques associes a la degenerescence maculaire liee a l'age
US8114592B2 (en) 2008-03-18 2012-02-14 Cambridge Enterprise Limited Genetic markers associated with age-related macular degeneration, methods of detection and uses thereof
CN104768533A (zh) 2012-06-11 2015-07-08 马库克利尔公司 治疗性制剂和治疗方法
GB201306627D0 (en) * 2013-04-11 2013-05-29 Thompson Richard Marker
JP6484215B2 (ja) 2013-03-14 2019-03-13 バクスアルタ インコーポレイテッド 関節リウマチの治療のためのｈ因子
PL2968457T3 (pl) 2013-03-14 2018-12-31 Baxalta Incorporated Czynnik h do transplantacji
AU2013202965B2 (en) 2013-03-15 2016-07-21 Takeda Pharmaceutical Company Limited Improved method for producing factor h from a plasma precipitation fraction
US9423394B2 (en) * 2013-12-13 2016-08-23 TheraOptix, Inc. Retinal pigment epithelial primary cell culture system producing subcellular deposits
US11253614B2 (en) 2016-08-23 2022-02-22 University Of Maryland, Baltimore Methods for detecting and/or predicting age-related macular degeneration and/or Alzheimer's disease
US20220128573A1 (en) * 2019-02-13 2022-04-28 Narayana Nethralaya Foundation Biomarkers for diagnosis of ocular diseases and the method thereof

Also Published As

Publication number Publication date
CA2363503A1 (fr) 2000-09-08
WO2000052479A3 (fr) 2001-02-01
AU3395800A (en) 2000-09-21
WO2000052479A2 (fr) 2000-09-08
EP1161686A2 (fr) 2001-12-12

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Effective date: 20180306