CA2362541A1 - Techniques de criblage a base de structure permettant de decouvrir un medicament - Google Patents

Techniques de criblage a base de structure permettant de decouvrir un medicament Download PDF

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Publication number
CA2362541A1
CA2362541A1 CA002362541A CA2362541A CA2362541A1 CA 2362541 A1 CA2362541 A1 CA 2362541A1 CA 002362541 A CA002362541 A CA 002362541A CA 2362541 A CA2362541 A CA 2362541A CA 2362541 A1 CA2362541 A1 CA 2362541A1
Authority
CA
Canada
Prior art keywords
analog
receptor
cell surface
naturally occurring
surface receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002362541A
Other languages
English (en)
Inventor
Peizhi Luo
Bassil Dahiyat
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Xencor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xencor Inc filed Critical Xencor Inc
Publication of CA2362541A1 publication Critical patent/CA2362541A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/746—Erythropoetin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L'invention concerne de nouveaux analogues de récepteur de surface cellulaire d'origine non naturelle, des analogues de ligand, et des acides nucléiques codant pour ceux-ci. L'invention concerne également des techniques de criblage d'analogues de ligand et d'agents bioactifs capables de moduler l'activité de signalisation d'un analogue de récepteur de surface cellulaire d'origine non naturelle ou de se lier audits analogues de récepteur de surface cellulaire d'origine non naturelle.
CA002362541A 1999-02-11 2000-02-11 Techniques de criblage a base de structure permettant de decouvrir un medicament Abandoned CA2362541A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12000999P 1999-02-11 1999-02-11
US60/120,009 1999-02-11
US13167499P 1999-04-29 1999-04-29
US60/131,674 1999-04-29
PCT/US2000/003665 WO2000047612A2 (fr) 1999-02-11 2000-02-11 Techniques de criblage a base de structure permettant de decouvrir un medicament

Publications (1)

Publication Number Publication Date
CA2362541A1 true CA2362541A1 (fr) 2000-08-17

Family

ID=26817948

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002362541A Abandoned CA2362541A1 (fr) 1999-02-11 2000-02-11 Techniques de criblage a base de structure permettant de decouvrir un medicament

Country Status (5)

Country Link
EP (1) EP1153295A2 (fr)
JP (1) JP2002540384A (fr)
AU (1) AU2880800A (fr)
CA (1) CA2362541A1 (fr)
WO (1) WO2000047612A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005024035A1 (fr) * 2003-09-05 2005-03-17 National Research Council Of Canada Proteine hybride bispiralee avec domaines de recepteurs cellulaires
US7786261B2 (en) 2004-09-02 2010-08-31 National Research Council Of Canada Coiled-coil fusion proteins comprising cell receptor domains

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8457903B1 (en) 1999-01-19 2013-06-04 Codexis Mayflower Holdings, Llc Method and/or apparatus for determining codons
US7702464B1 (en) 2001-08-21 2010-04-20 Maxygen, Inc. Method and apparatus for codon determining
US7873477B1 (en) 2001-08-21 2011-01-18 Codexis Mayflower Holdings, Llc Method and system using systematically varied data libraries
CA2501459A1 (fr) * 2002-10-11 2004-04-22 Zymogenetics, Inc. Production de proteines hybrides homo-trimeriques

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5292654A (en) * 1990-12-13 1994-03-08 Whitehead Institute For Biomedical Research Mutant EPO receptor and uses therefor
JPH0638787A (ja) * 1992-03-04 1994-02-15 Snow Brand Milk Prod Co Ltd 可溶性エリスロポエチン受容体蛋白質、およびそのアミノ酸配列をコードする遺伝子
JPH08508889A (ja) * 1993-06-07 1996-09-24 アムジエン・インコーポレーテツド ハイブリッドレセプター分子
US5834318A (en) * 1995-05-10 1998-11-10 Bayer Corporation Screening of combinatorial peptide libraries for selection of peptide ligand useful in affinity purification of target proteins
EP0974111B1 (fr) * 1997-04-11 2003-01-08 California Institute Of Technology Dispositif et methode permettant une mise au point informatisee de proteines

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005024035A1 (fr) * 2003-09-05 2005-03-17 National Research Council Of Canada Proteine hybride bispiralee avec domaines de recepteurs cellulaires
US7786261B2 (en) 2004-09-02 2010-08-31 National Research Council Of Canada Coiled-coil fusion proteins comprising cell receptor domains

Also Published As

Publication number Publication date
WO2000047612A3 (fr) 2000-12-14
WO2000047612A2 (fr) 2000-08-17
JP2002540384A (ja) 2002-11-26
EP1153295A2 (fr) 2001-11-14
AU2880800A (en) 2000-08-29

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Legal Events

Date Code Title Description
FZDE Discontinued