CA2360584A1 - Proteine-12 a mammalienne helice alpha - Google Patents

Proteine-12 a mammalienne helice alpha Download PDF

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Publication number
CA2360584A1
CA2360584A1 CA002360584A CA2360584A CA2360584A1 CA 2360584 A1 CA2360584 A1 CA 2360584A1 CA 002360584 A CA002360584 A CA 002360584A CA 2360584 A CA2360584 A CA 2360584A CA 2360584 A1 CA2360584 A1 CA 2360584A1
Authority
CA
Canada
Prior art keywords
leu
ser
ala
polypeptide
zalphal2
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002360584A
Other languages
English (en)
Inventor
Darrell C. Conklin
Emily Cooper
Stephen R. Jaspers
Joyce M. Lehner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zymogenetics Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2360584A1 publication Critical patent/CA2360584A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Abstract

La présente invention concerne des molécules polynucléotidiques et polypeptidiques de la protéine-12 mammalienne à hélice alpha (Zalpha-12). Les polypeptides et les polynucléotides codant ces polypeptides sont hormonaux et peuvent être utilisés pour réguler le fonctionnement du système immunitaire. L'invention concerne en outre des anticorps anti-polypeptides Zalpha-12. Des antagonistes sont utilisés pour traiter des inflammations et des maladies apparentées à des inflammations.
CA002360584A 1999-01-15 2000-01-14 Proteine-12 a mammalienne helice alpha Abandoned CA2360584A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23242799A 1999-01-15 1999-01-15
US09/232,427 1999-01-15
PCT/US2000/001015 WO2000042070A1 (fr) 1999-01-15 2000-01-14 Proteine-12 a mammalienne helice alpha

Publications (1)

Publication Number Publication Date
CA2360584A1 true CA2360584A1 (fr) 2000-07-20

Family

ID=22873060

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002360584A Abandoned CA2360584A1 (fr) 1999-01-15 2000-01-14 Proteine-12 a mammalienne helice alpha

Country Status (5)

Country Link
EP (1) EP1144450A1 (fr)
JP (1) JP2002534964A (fr)
AU (1) AU2728200A (fr)
CA (1) CA2360584A1 (fr)
WO (1) WO2000042070A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004009626A1 (fr) * 2002-07-22 2004-01-29 Yamanouchi Pharmaceutical Co., Ltd. Nouveau gene associe a l'arthrite rhumatoide

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6171824B1 (en) * 1991-08-30 2001-01-09 Fred Hutchinson Cancer Research Center Hybrid cytokines
AU4289193A (en) * 1992-04-17 1993-11-18 University Hospital, The Mutant cytokines having increased receptor affinity
WO1999029720A2 (fr) * 1997-12-10 1999-06-17 Zymogenetics, Inc. Proteine 1 mammalienne a helice alpha

Also Published As

Publication number Publication date
EP1144450A1 (fr) 2001-10-17
JP2002534964A (ja) 2002-10-22
WO2000042070A1 (fr) 2000-07-20
AU2728200A (en) 2000-08-01

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Legal Events

Date Code Title Description
FZDE Discontinued