CA2356969A1 - 3-substituted pyrrolidines useful as inhibitors of matrix metallo-proteinases - Google Patents

3-substituted pyrrolidines useful as inhibitors of matrix metallo-proteinases Download PDF

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Publication number
CA2356969A1
CA2356969A1 CA002356969A CA2356969A CA2356969A1 CA 2356969 A1 CA2356969 A1 CA 2356969A1 CA 002356969 A CA002356969 A CA 002356969A CA 2356969 A CA2356969 A CA 2356969A CA 2356969 A1 CA2356969 A1 CA 2356969A1
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CA
Canada
Prior art keywords
group
hydrogen
alkyl
formula
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002356969A
Other languages
English (en)
French (fr)
Inventor
Gary A. Flynn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2356969A1 publication Critical patent/CA2356969A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002356969A 1998-12-31 1999-11-30 3-substituted pyrrolidines useful as inhibitors of matrix metallo-proteinases Abandoned CA2356969A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22445698A 1998-12-31 1998-12-31
US09/224,456 1998-12-31
PCT/US1999/028234 WO2000040553A1 (en) 1998-12-31 1999-11-30 3-substituted pyrrolidines useful as inhibitors of matrix metallo-proteinases

Publications (1)

Publication Number Publication Date
CA2356969A1 true CA2356969A1 (en) 2000-07-13

Family

ID=22840773

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002356969A Abandoned CA2356969A1 (en) 1998-12-31 1999-11-30 3-substituted pyrrolidines useful as inhibitors of matrix metallo-proteinases

Country Status (5)

Country Link
EP (1) EP1150951A1 (de)
AR (1) AR023079A1 (de)
AU (1) AU1926500A (de)
CA (1) CA2356969A1 (de)
WO (1) WO2000040553A1 (de)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3889726T2 (de) * 1987-03-17 1994-10-13 Res Corp Technologies Inc Synthetische inhibitoren von säugetier-collagenase.
DE69717647T2 (de) * 1996-09-19 2003-09-25 Aventis Pharmaceuticals Inc., Bridgewater 3-mercaptoacetylamino-1,5-substituierte-2-oxo-azepan derivate und deren verwendung als inhibitoren von matrix-metalloproteinasen
WO1998053817A1 (en) * 1997-05-29 1998-12-03 Merck & Co., Inc. Biarylalkanoic acids as cell adhesion inhibitors

Also Published As

Publication number Publication date
WO2000040553A1 (en) 2000-07-13
EP1150951A1 (de) 2001-11-07
AR023079A1 (es) 2002-09-04
AU1926500A (en) 2000-07-24

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead