CA2355187A1 - Methode et appareil permettant de produire une cavitation homogene en vue d'un transport transdermique - Google Patents

Methode et appareil permettant de produire une cavitation homogene en vue d'un transport transdermique Download PDF

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Publication number
CA2355187A1
CA2355187A1 CA002355187A CA2355187A CA2355187A1 CA 2355187 A1 CA2355187 A1 CA 2355187A1 CA 002355187 A CA002355187 A CA 002355187A CA 2355187 A CA2355187 A CA 2355187A CA 2355187 A1 CA2355187 A1 CA 2355187A1
Authority
CA
Canada
Prior art keywords
ultrasound
skin
cavitation
area
horn
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002355187A
Other languages
English (en)
Inventor
Samir S. Mitragotri
Joseph Kost
Scott C. Kellogg
Nick Warner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sontra Medical Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2355187A1 publication Critical patent/CA2355187A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B2017/22005—Effects, e.g. on tissue
    • A61B2017/22007—Cavitation or pseudocavitation, i.e. creation of gas bubbles generating a secondary shock wave when collapsing
    • A61B2017/22008—Cavitation or pseudocavitation, i.e. creation of gas bubbles generating a secondary shock wave when collapsing used or promoted
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B2017/22027—Features of transducers

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Surgical Instruments (AREA)
  • External Artificial Organs (AREA)

Abstract

La présente invention concerne un dispositif et une méthode permettant de produire une cavitation homogène. Une source d'ultrasons comprend un élément (20) émetteur d'ultrasons présentant un axe (5) et une section transversale le long de cet axe. Cet élément comporte une première extrémité axiale (1) et une seconde extrémité axiale (2) émettant des ondes ultrasoniques. La surface de la section est maximum au niveau de la première extrémité axiale et minimum au niveau de la seconde extrémité axiale. L'invention concerne également une méthode permettant de produire une cavitation homogène dans une zone de la peau. Cette méthode consiste à créer un volume de liquide présentant une concentration à dispersion uniforme de noyaux de cavitation contre la surface de la peau, puis à appliquer des ultrasons au volume de fluide pour déclencher une cavitation des noyaux de cavitation.
CA002355187A 1998-12-18 1999-12-17 Methode et appareil permettant de produire une cavitation homogene en vue d'un transport transdermique Abandoned CA2355187A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11293698P 1998-12-18 1998-12-18
US60/112,936 1998-12-18
PCT/US1999/030067 WO2000035351A1 (fr) 1998-12-18 1999-12-17 Methode et appareil permettant de produire une cavitation homogene en vue d'un transport transdermique

Publications (1)

Publication Number Publication Date
CA2355187A1 true CA2355187A1 (fr) 2000-06-22

Family

ID=22346647

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002355187A Abandoned CA2355187A1 (fr) 1998-12-18 1999-12-17 Methode et appareil permettant de produire une cavitation homogene en vue d'un transport transdermique

Country Status (5)

Country Link
EP (1) EP1139880A4 (fr)
JP (1) JP2002542841A (fr)
AU (1) AU768190B2 (fr)
CA (1) CA2355187A1 (fr)
WO (1) WO2000035351A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE221665T1 (de) 1998-06-24 2002-08-15 Transderm Technologies Llc Nichtinvasiven transdermal detektion von analyten
US7229621B2 (en) * 1998-10-20 2007-06-12 Torrey Pines Institute For Molecular Studies Method to enhance the immunogenicity of an antigen
US20040171980A1 (en) 1998-12-18 2004-09-02 Sontra Medical, Inc. Method and apparatus for enhancement of transdermal transport
EP1225831A2 (fr) 2000-03-17 2002-07-31 Sontra Medical, Inc. Systeme, procede et dispositif pour le prelevement non-invasif et l'analyse de fluides organiques
US8734325B2 (en) 2006-06-07 2014-05-27 Trinity Wound Institute, Llc Oxygen therapy with ultrasound
BRPI0810969A2 (pt) 2007-04-27 2015-01-27 Echo Therapeutics Inc Dispositivo de permeação da pele para a detecção de analito ou liberação transdermal de fármaco
WO2016190703A1 (fr) * 2015-05-28 2016-12-01 주식회사 퍼시픽시스템 Germes de cavitation pour l'administration de médicaments, et procédé d'administration de médicaments qui les utilise

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0532094Y2 (fr) * 1988-05-17 1993-08-18
US5038756A (en) * 1989-10-30 1991-08-13 Storz Instrument Company Needle interface boot for ultrasonic surgical instrument
US5112300A (en) * 1990-04-03 1992-05-12 Alcon Surgical, Inc. Method and apparatus for controlling ultrasonic fragmentation of body tissue
US5362309A (en) * 1992-09-14 1994-11-08 Coraje, Inc. Apparatus and method for enhanced intravascular phonophoresis including dissolution of intravascular blockage and concomitant inhibition of restenosis
US5421816A (en) * 1992-10-14 1995-06-06 Endodermic Medical Technologies Company Ultrasonic transdermal drug delivery system
WO1997022325A1 (fr) * 1995-12-20 1997-06-26 Sonex International Corporation Procede et appareil soniques pour applications cosmetiques
US6234990B1 (en) * 1996-06-28 2001-05-22 Sontra Medical, Inc. Ultrasound enhancement of transdermal transport

Also Published As

Publication number Publication date
EP1139880A4 (fr) 2005-08-17
AU768190B2 (en) 2003-12-04
WO2000035351A9 (fr) 2001-05-10
EP1139880A1 (fr) 2001-10-10
AU2192100A (en) 2000-07-03
JP2002542841A (ja) 2002-12-17
WO2000035351A1 (fr) 2000-06-22

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued