CA2350913A1 - Substances wk-5344a and wk-5344b and process for producing the same - Google Patents
Substances wk-5344a and wk-5344b and process for producing the same Download PDFInfo
- Publication number
- CA2350913A1 CA2350913A1 CA002350913A CA2350913A CA2350913A1 CA 2350913 A1 CA2350913 A1 CA 2350913A1 CA 002350913 A CA002350913 A CA 002350913A CA 2350913 A CA2350913 A CA 2350913A CA 2350913 A1 CA2350913 A1 CA 2350913A1
- Authority
- CA
- Canada
- Prior art keywords
- substance
- medium
- inhibitory action
- transfer protein
- substances
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000126 substance Substances 0.000 title abstract 12
- 238000000034 method Methods 0.000 title abstract 2
- 102000012336 Cholesterol Ester Transfer Proteins Human genes 0.000 abstract 2
- 108010061846 Cholesterol Ester Transfer Proteins Proteins 0.000 abstract 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 241000187747 Streptomyces Species 0.000 abstract 1
- 238000009825 accumulation Methods 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/008—Preparation of nitrogen-containing organic compounds containing a N-O bond, e.g. nitro (-NO2), nitroso (-NO)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/02—Iron compounds
- C07F15/025—Iron compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P9/00—Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to novel substance having inhibitory action on cholesteryl ester transfer protein. WK-5344A
substance and WK-5344B substance, and process for production thereof.
A microorganism belonging to genus Streptomyces having ability to produce WK-5344A substance and WK-5344B substance is cultured in a medium, and the WK-5344A substance and the WK-5344B substance are accumulated in the medium, then the WK-5344A substance and the WK-5344B substance are isolated from the said medium. Since the present substance shows significant inhibitory action on cholesteryl ester transfer protein, the substance is effective for prevention and treatment of diseases caused by accumulation of cholesterol in human.
substance and WK-5344B substance, and process for production thereof.
A microorganism belonging to genus Streptomyces having ability to produce WK-5344A substance and WK-5344B substance is cultured in a medium, and the WK-5344A substance and the WK-5344B substance are accumulated in the medium, then the WK-5344A substance and the WK-5344B substance are isolated from the said medium. Since the present substance shows significant inhibitory action on cholesteryl ester transfer protein, the substance is effective for prevention and treatment of diseases caused by accumulation of cholesterol in human.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/JP1999/001101 WO2000053792A1 (en) | 1999-03-08 | 1999-03-08 | Substances wk-5344a and wk-5344b and process for producing the same |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2350913A1 true CA2350913A1 (en) | 2000-09-14 |
CA2350913C CA2350913C (en) | 2007-01-30 |
Family
ID=14235131
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002350913A Expired - Fee Related CA2350913C (en) | 1999-03-08 | 1999-03-08 | Substances wk-5344a and wk-5344b and process for producing the same |
Country Status (14)
Country | Link |
---|---|
US (1) | US6512008B1 (en) |
EP (1) | EP1160330B1 (en) |
JP (1) | JP4351395B2 (en) |
KR (1) | KR100436036B1 (en) |
CN (1) | CN1139660C (en) |
AU (1) | AU751849B2 (en) |
BR (1) | BR9916018A (en) |
CA (1) | CA2350913C (en) |
DE (1) | DE69932746D1 (en) |
HU (1) | HUP0105166A3 (en) |
NO (1) | NO20012606L (en) |
NZ (1) | NZ511728A (en) |
RU (1) | RU2201964C2 (en) |
WO (1) | WO2000053792A1 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7115279B2 (en) | 2000-08-03 | 2006-10-03 | Curatolo William J | Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors |
EP1269994A3 (en) | 2001-06-22 | 2003-02-12 | Pfizer Products Inc. | Pharmaceutical compositions comprising drug and concentration-enhancing polymers |
AR038375A1 (en) | 2002-02-01 | 2005-01-12 | Pfizer Prod Inc | PHARMACEUTICAL COMPOSITIONS OF INHIBITORS OF THE PROTEIN OF TRANSFER OF ESTERES DE COLESTERILO |
WO2005030185A2 (en) | 2003-09-26 | 2005-04-07 | Japan Tobacco Inc. | Method of inhibiting remnant lipoprotein production |
WO2006098394A1 (en) * | 2005-03-14 | 2006-09-21 | Japan Tobacco Inc. | Method for inhibiting lipid absorption and lipid absorption inhibitor |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5272174A (en) * | 1985-09-13 | 1993-12-21 | Sankyo Company, Limited | Hydroxy-ML-236B derivatives, their preparation and use |
-
1999
- 1999-03-08 RU RU2001114212/13A patent/RU2201964C2/en not_active IP Right Cessation
- 1999-03-08 US US09/857,268 patent/US6512008B1/en not_active Expired - Fee Related
- 1999-03-08 DE DE69932746T patent/DE69932746D1/en not_active Expired - Lifetime
- 1999-03-08 CA CA002350913A patent/CA2350913C/en not_active Expired - Fee Related
- 1999-03-08 AU AU32754/99A patent/AU751849B2/en not_active Withdrawn - After Issue
- 1999-03-08 CN CNB998155659A patent/CN1139660C/en not_active Expired - Fee Related
- 1999-03-08 KR KR10-2001-7006383A patent/KR100436036B1/en not_active IP Right Cessation
- 1999-03-08 BR BR9916018-8A patent/BR9916018A/en not_active IP Right Cessation
- 1999-03-08 WO PCT/JP1999/001101 patent/WO2000053792A1/en active IP Right Grant
- 1999-03-08 HU HU0105166A patent/HUP0105166A3/en unknown
- 1999-03-08 JP JP2000603413A patent/JP4351395B2/en not_active Expired - Fee Related
- 1999-03-08 NZ NZ511728A patent/NZ511728A/en unknown
- 1999-03-08 EP EP99973760A patent/EP1160330B1/en not_active Expired - Lifetime
-
2001
- 2001-05-28 NO NO20012606A patent/NO20012606L/en unknown
Also Published As
Publication number | Publication date |
---|---|
CN1139660C (en) | 2004-02-25 |
AU3275499A (en) | 2000-09-28 |
EP1160330B1 (en) | 2006-08-09 |
NZ511728A (en) | 2003-06-30 |
EP1160330A4 (en) | 2003-07-09 |
DE69932746D1 (en) | 2006-09-21 |
BR9916018A (en) | 2001-11-13 |
KR20010107979A (en) | 2001-12-07 |
JP4351395B2 (en) | 2009-10-28 |
US6512008B1 (en) | 2003-01-28 |
HUP0105166A2 (en) | 2002-04-29 |
EP1160330A1 (en) | 2001-12-05 |
NO20012606D0 (en) | 2001-05-28 |
CN1333836A (en) | 2002-01-30 |
AU751849B2 (en) | 2002-08-29 |
HUP0105166A3 (en) | 2003-10-28 |
KR100436036B1 (en) | 2004-06-12 |
NO20012606L (en) | 2001-11-08 |
CA2350913C (en) | 2007-01-30 |
WO2000053792A1 (en) | 2000-09-14 |
RU2201964C2 (en) | 2003-04-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |