CA2346728C - Caracterisation de la luminescence dans un milieu de dispersion - Google Patents

Caracterisation de la luminescence dans un milieu de dispersion Download PDF

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Publication number
CA2346728C
CA2346728C CA2346728A CA2346728A CA2346728C CA 2346728 C CA2346728 C CA 2346728C CA 2346728 A CA2346728 A CA 2346728A CA 2346728 A CA2346728 A CA 2346728A CA 2346728 C CA2346728 C CA 2346728C
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CA
Canada
Prior art keywords
light
wavelength
medium
luminophore
excitation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2346728A
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English (en)
Other versions
CA2346728A1 (fr
Inventor
Eva M. Sevick-Muraca
Ralf H. Mayer
Jeffery S. Reynolds
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Texas A&M University System
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Texas A&M University System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Texas A&M University System filed Critical Texas A&M University System
Publication of CA2346728A1 publication Critical patent/CA2346728A1/fr
Application granted granted Critical
Publication of CA2346728C publication Critical patent/CA2346728C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4795—Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium

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  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

L'invention concerne un système (20), comprenant des instruments (30) de source lumineuse qui permettent d'éclairer sélectivement un milieu de dispersion de la lumière doté d'un luminophore, et des instruments de détection (50) qui permettent de détecter une sortie lumineuse dispersée plusieurs fois à partir du milieu, en réponse à un éclairement par les instruments (30) de source lumineuse. Un processeur (70) est couplé, de manière fonctionnelle, aux instruments de détection (50) afin de déterminer une première caractérisation optique du milieu, à partir d'une sortie lumineuse dispersée plusieurs fois d'une première longueur d'onde de lumière d'éclairement, et une deuxième caractérisation optique du milieu, à partir d'une deuxième sortie de lumière dispersée plusieurs fois d'une deuxième longueur d'onde de lumière d'éclairement différente de la première. Le processeur (70) fonctionne de manière à calculer la durée de vie du luminophore, à partir des première et deuxième caractérisations, et d'une émission du luminophore dispersée plusieurs fois à partir du milieu en réponse à une excitation.
CA2346728A 1998-10-09 1999-10-08 Caracterisation de la luminescence dans un milieu de dispersion Expired - Fee Related CA2346728C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10360998P 1998-10-09 1998-10-09
US60/103,609 1998-10-09
PCT/US1999/023709 WO2000022414A1 (fr) 1998-10-09 1999-10-08 Caracterisation de la luminescence dans un milieu de dispersion

Publications (2)

Publication Number Publication Date
CA2346728A1 CA2346728A1 (fr) 2000-04-20
CA2346728C true CA2346728C (fr) 2013-04-23

Family

ID=22296070

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2346728A Expired - Fee Related CA2346728C (fr) 1998-10-09 1999-10-08 Caracterisation de la luminescence dans un milieu de dispersion

Country Status (5)

Country Link
EP (1) EP1127262A4 (fr)
AU (1) AU1109900A (fr)
CA (1) CA2346728C (fr)
NO (1) NO20011791L (fr)
WO (1) WO2000022414A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7328059B2 (en) 1996-08-23 2008-02-05 The Texas A & M University System Imaging of light scattering tissues with fluorescent contrast agents
US7865230B1 (en) 1997-02-07 2011-01-04 Texas A&M University System Method and system for detecting sentinel lymph nodes
US7054002B1 (en) 1999-10-08 2006-05-30 The Texas A&M University System Characterization of luminescence in a scattering medium
EP1390714A2 (fr) * 2001-04-03 2004-02-25 THE TEXAS A & M UNIVERSITY SYSTEMS Caracterisation de particules en suspension a partir de mesures des migrations photoniques par domaine de frequence
US6930777B1 (en) 2001-04-03 2005-08-16 The Texas A&M University System Method for characterizing particles in suspension from frequency domain photon migration measurements
US7599732B2 (en) 2003-06-20 2009-10-06 The Texas A&M University System Method and system for near-infrared fluorescence contrast-enhanced imaging with area illumination and area detection

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5190729A (en) * 1986-09-08 1993-03-02 C. R. Bard, Inc. Luminescent oxygen sensor based on a lanthanide complex
EP0694164A1 (fr) * 1991-05-03 1996-01-31 Joseph R. Lakowicz Procede de mesure optique d'analytes chimiques
US5736410A (en) * 1992-09-14 1998-04-07 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
US5818583A (en) * 1996-11-08 1998-10-06 Purdue Research Foundation Particle analysis system and method

Also Published As

Publication number Publication date
EP1127262A4 (fr) 2002-09-25
NO20011791D0 (no) 2001-04-09
NO20011791L (no) 2001-06-08
WO2000022414A1 (fr) 2000-04-20
AU1109900A (en) 2000-05-01
EP1127262A1 (fr) 2001-08-29
CA2346728A1 (fr) 2000-04-20

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Effective date: 20171010