CA2343099A1 - Role of human kis (hkis) as an inhibitory kinase of the cyclin-dependentkinase inhibitor p27. compositions, methods and uses thereof to control cell proliferation - Google Patents

Role of human kis (hkis) as an inhibitory kinase of the cyclin-dependentkinase inhibitor p27. compositions, methods and uses thereof to control cell proliferation Download PDF

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Publication number
CA2343099A1
CA2343099A1 CA002343099A CA2343099A CA2343099A1 CA 2343099 A1 CA2343099 A1 CA 2343099A1 CA 002343099 A CA002343099 A CA 002343099A CA 2343099 A CA2343099 A CA 2343099A CA 2343099 A1 CA2343099 A1 CA 2343099A1
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CA
Canada
Prior art keywords
hkis
methods
cyclin
dependentkinase
kis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002343099A
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French (fr)
Other versions
CA2343099C (en
Inventor
Gary J. Nabel
Elizabeth G. Nabel
Manfred Boehm
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Michigan
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Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2343099A1 publication Critical patent/CA2343099A1/en
Application granted granted Critical
Publication of CA2343099C publication Critical patent/CA2343099C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4738—Cell cycle regulated proteins, e.g. cyclin, CDC, INK-CCR
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Disclosed herein are novel composition and methods for altering the proliferation of a cell. Included are wild-type and mutant hKIS
polypeptides along with cyclin kinase inhibitors containing mutations that prevent their inhibition with serine/threonine kinases.
CA002343099A 1998-08-21 1999-08-20 Role of human kis (hkis) as an inhibitory kinase of the cyclin-dependentkinase inhibitor p27. compositions, methods and uses thereof to control cell proliferation Expired - Fee Related CA2343099C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9771098P 1998-08-21 1998-08-21
US60/097,710 1998-08-21
PCT/US1999/018903 WO2000011165A1 (en) 1998-08-21 1999-08-20 ROLE OF HUMAN KIS (hKIS) AS AN INHIBITORY KINASE OF THE CYCLIN-DEPENDENT KINASE INHIBITOR P27. COMPOSITIONS, METHODS AND USES THEREOF TO CONTROL CELL PROLIFERATION

Publications (2)

Publication Number Publication Date
CA2343099A1 true CA2343099A1 (en) 2000-03-02
CA2343099C CA2343099C (en) 2006-11-14

Family

ID=22264764

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002343099A Expired - Fee Related CA2343099C (en) 1998-08-21 1999-08-20 Role of human kis (hkis) as an inhibitory kinase of the cyclin-dependentkinase inhibitor p27. compositions, methods and uses thereof to control cell proliferation

Country Status (4)

Country Link
EP (1) EP1104463A1 (en)
AU (1) AU5572599A (en)
CA (1) CA2343099C (en)
WO (1) WO2000011165A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0010616A (en) 1999-04-15 2002-05-07 Calgene Llc Nucleic acid sequences to proteins involved in isoprenoid synthesis
US20020025931A1 (en) 2000-03-24 2002-02-28 Rachel Meyers 3714, 16742, 23546, and 13887 novel protein kinase molecules and uses therefor
US6872815B1 (en) 2000-10-14 2005-03-29 Calgene Llc Nucleic acid sequences to proteins involved in tocopherol synthesis
WO2002012478A2 (en) 2000-08-07 2002-02-14 Monsanto Technology, Llc Methyl-d-erythritol phosphate pathway genes
JP2004533244A (en) 2001-05-09 2004-11-04 モンサント テクノロジー リミテッド ライアビリティー カンパニー TyrA gene and uses thereof
US7161061B2 (en) 2001-05-09 2007-01-09 Monsanto Technology Llc Metabolite transporters
US7244877B2 (en) 2001-08-17 2007-07-17 Monsanto Technology Llc Methyltransferase from cotton and uses thereof
CN100400661C (en) 2001-10-25 2008-07-09 孟山都技术有限公司 Aromatic methyltransferases and uses thereof
CA2478957C (en) 2002-03-19 2013-07-02 Monsanto Technology, Llc Homogentisate prenyl transferase ("hpt") nucleic acids and polypeptides, and uses thereof
CN1681928A (en) 2002-08-05 2005-10-12 孟山都技术公司 Tocopherol biosynthesis related genes and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6682728B1 (en) * 1993-10-13 2004-01-27 The United States Of America As Represented By The Department Of Health And Human Services Efficient and selective adenoviral-mediated gene transfer into vascular neointima

Also Published As

Publication number Publication date
WO2000011165A1 (en) 2000-03-02
EP1104463A1 (en) 2001-06-06
CA2343099C (en) 2006-11-14
AU5572599A (en) 2000-03-14
WO2000011165A9 (en) 2000-06-22

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