CA2343076A1 - Classification geometrique et hierarchique fondee sur l'expression genetique - Google Patents

Classification geometrique et hierarchique fondee sur l'expression genetique Download PDF

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Publication number
CA2343076A1
CA2343076A1 CA002343076A CA2343076A CA2343076A1 CA 2343076 A1 CA2343076 A1 CA 2343076A1 CA 002343076 A CA002343076 A CA 002343076A CA 2343076 A CA2343076 A CA 2343076A CA 2343076 A1 CA2343076 A1 CA 2343076A1
Authority
CA
Canada
Prior art keywords
cells
subsequence
class
subsequences
pair
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002343076A
Other languages
English (en)
Inventor
Joel S. Bader
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CuraGen Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2343076A1 publication Critical patent/CA2343076A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
    • C12Q1/6855—Ligating adaptors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection

Abstract

L'invention concerne une technique permettant de créer une représentation du degré de parenté entre au moins deux classes de cellules. L'invention a trait également à une technique permettant de créer une représentation de la corrélation entre une première et seconde classes de cellules. La corrélation représente un changement dans la nature et la quantité d'acides nucléiques présents dans les classes. Ces techniques consistent à sélectionner les cellules de chaque classe parmi des cellules d'un type de cellule donnée, des cellules d'un tissu donné, et des cellules d'un organe donné. Ces techniques permettent d'établir des similitudes ou des différences entre les classes en définissant plusieurs paires de sous-séquences de nucléotides, chaque paire comprenant une première et seconde sous-séquences. Elles consistent également à déterminer dans l'acide nucléique de chaque classe de cellules, la présence d'un fragment comportant la première sous-séquence à une extrémité et la seconde sous-séquence à une autre extrémité, fragment qui possède une longueur séparant la première et la seconde sous-séquences, et à déterminer dans quelle mesure le fragment est présent. Ces techniques permettent de déterminer le degré de parenté reflétant les similitudes ou les différences parmi les classes. Par ailleurs, l'invention concerne un dispositif d'affichage affichant une représentation du degré de parenté entre les classes de cellules, ainsi qu'une représentation de la corrélation entre la première et seconde classes de cellules. De plus, l'invention porte sur une représentation du degré de parenté entre les classes de cellules, et une représentation de la corrélation entre la première et seconde classes de cellules.
CA002343076A 1998-09-17 1999-09-17 Classification geometrique et hierarchique fondee sur l'expression genetique Abandoned CA2343076A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US10100998P 1998-09-17 1998-09-17
US39840499A 1999-09-16 1999-09-16
US09/398,404 1999-09-16
US60/101,009 1999-09-16
PCT/US1999/021525 WO2000015851A1 (fr) 1998-09-17 1999-09-17 Classification geometrique et hierarchique fondee sur l'expression genetique

Publications (1)

Publication Number Publication Date
CA2343076A1 true CA2343076A1 (fr) 2000-03-23

Family

ID=26797803

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002343076A Abandoned CA2343076A1 (fr) 1998-09-17 1999-09-17 Classification geometrique et hierarchique fondee sur l'expression genetique

Country Status (5)

Country Link
EP (1) EP1114187A1 (fr)
JP (1) JP2002525079A (fr)
AU (1) AU6047299A (fr)
CA (1) CA2343076A1 (fr)
WO (1) WO2000015851A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020090612A1 (en) * 1999-01-08 2002-07-11 Jonathan M. Rothberg Method of identifying nucleic acids
US7016788B2 (en) 2000-07-07 2006-03-21 Curagen Corporation Methods for classifying nucleic acids and polypeptides
US7332272B1 (en) 2000-12-06 2008-02-19 Erik Gunther Method for screening and identifying pharmaceutical agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2036946C (fr) * 1990-04-06 2001-10-16 Kenneth V. Deugau Molecules de liaison pour indexation
WO1997013877A1 (fr) * 1995-10-12 1997-04-17 Lynx Therapeutics, Inc. Mesure de profils d'expression genique pour evaluer la toxicite
US5972693A (en) * 1995-10-24 1999-10-26 Curagen Corporation Apparatus for identifying, classifying, or quantifying DNA sequences in a sample without sequencing
US6156502A (en) * 1995-12-21 2000-12-05 Beattie; Kenneth Loren Arbitrary sequence oligonucleotide fingerprinting
WO1997029211A1 (fr) * 1996-02-09 1997-08-14 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services VISUALISATION PAR RESTRICTION (RD-PCR) DES ARNm EXPRIMES DE MANIERE DIFFERENTIELLE

Also Published As

Publication number Publication date
AU6047299A (en) 2000-04-03
EP1114187A1 (fr) 2001-07-11
WO2000015851A1 (fr) 2000-03-23
JP2002525079A (ja) 2002-08-13

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Legal Events

Date Code Title Description
FZDE Discontinued