CA2342912A1 - Administration locale d'un medicament pour le coeur - Google Patents

Administration locale d'un medicament pour le coeur Download PDF

Info

Publication number
CA2342912A1
CA2342912A1 CA002342912A CA2342912A CA2342912A1 CA 2342912 A1 CA2342912 A1 CA 2342912A1 CA 002342912 A CA002342912 A CA 002342912A CA 2342912 A CA2342912 A CA 2342912A CA 2342912 A1 CA2342912 A1 CA 2342912A1
Authority
CA
Canada
Prior art keywords
microparticles
agent
heart
drug
microparticle composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002342912A
Other languages
English (en)
Inventor
Ronald K. Yamamoto
Stephen D. Pacetti
Thomas B. Ottoboni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Point Biomedical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Point Biomedical Corp filed Critical Point Biomedical Corp
Publication of CA2342912A1 publication Critical patent/CA2342912A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne des compositions de microparticules, contenant des agents pharmacologiques efficaces lorsqu'on les libère localement au niveau du coeur. Ces agents sont introduits dans la circulation sanguine et leur emplacement est surveillé par des ultrasons ou d'autres moyens. Les microparticules sont brisées par l'énergie ultrasonique selon une condition ultrasonique définie, lorsque cette énergie est dirigée localement sur une partie du coeur.
CA002342912A 1998-09-02 1999-09-02 Administration locale d'un medicament pour le coeur Abandoned CA2342912A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9897598P 1998-09-02 1998-09-02
US60/098,975 1998-09-02
PCT/US1999/020388 WO2000012062A1 (fr) 1998-09-02 1999-09-02 Administration locale d'un medicament pour le coeur

Publications (1)

Publication Number Publication Date
CA2342912A1 true CA2342912A1 (fr) 2000-03-09

Family

ID=22271802

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002342912A Abandoned CA2342912A1 (fr) 1998-09-02 1999-09-02 Administration locale d'un medicament pour le coeur

Country Status (5)

Country Link
EP (1) EP1109531A1 (fr)
AU (1) AU6027899A (fr)
CA (1) CA2342912A1 (fr)
NO (1) NO20011103D0 (fr)
WO (1) WO2000012062A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6896659B2 (en) 1998-02-06 2005-05-24 Point Biomedical Corporation Method for ultrasound triggered drug delivery using hollow microbubbles with controlled fragility
US6969382B2 (en) 1999-07-26 2005-11-29 Zuli Holdings, Ltd. Method and apparatus for treating bodily tissues with medicinal substance
US6334859B1 (en) 1999-07-26 2002-01-01 Zuli Holdings Ltd. Subcutaneous apparatus and subcutaneous method for treating bodily tissues with electricity or medicaments
WO2001012071A1 (fr) 1999-08-13 2001-02-22 Point Biomedical Corporation Microparticules utiles en tant qu'agents de contraste sous l'effet d'ultrasons pour le systeme lymphatique
EP1202670A4 (fr) 1999-08-13 2004-11-10 Point Biomedical Corp Microspheres creuses a fragilite controlee a usage medical
US6527718B1 (en) 1999-08-20 2003-03-04 Brian G Connor Ultrasound system for continuous imaging and delivery of an encapsulated agent
US6740039B1 (en) 1999-08-20 2004-05-25 Koninklijke Philips Electronics N.V. Methods and apparatus for displaying information relating to delivery and activation of a therapeutic agent using ultrasound energy
EP2120722B1 (fr) 2007-03-09 2014-05-07 Koninklijke Philips N.V. Commande de la libération d'un matériau porté par des particules sensibles aux ultrasons

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4962091A (en) * 1986-05-23 1990-10-09 Syntex (U.S.A.) Inc. Controlled release of macromolecular polypeptides
US5650156A (en) * 1993-02-22 1997-07-22 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of nutriceuticals and compositions useful therefor
US5858990A (en) * 1997-03-04 1999-01-12 St. Elizabeth's Medical Center Fas ligand compositions for treatment of proliferative disorders

Also Published As

Publication number Publication date
NO20011103D0 (no) 2001-03-02
WO2000012062A1 (fr) 2000-03-09
EP1109531A1 (fr) 2001-06-27
AU6027899A (en) 2000-03-21

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Legal Events

Date Code Title Description
FZDE Discontinued