CA2339553C - Procede de separation d'isomeres et de differentes conformations d'ions en phase gazeuse - Google Patents
Procede de separation d'isomeres et de differentes conformations d'ions en phase gazeuse Download PDFInfo
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- CA2339553C CA2339553C CA002339553A CA2339553A CA2339553C CA 2339553 C CA2339553 C CA 2339553C CA 002339553 A CA002339553 A CA 002339553A CA 2339553 A CA2339553 A CA 2339553A CA 2339553 C CA2339553 C CA 2339553C
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- 150000002500 ions Chemical class 0.000 title claims abstract description 310
- 238000000034 method Methods 0.000 title claims abstract description 63
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 title claims description 5
- 238000000926 separation method Methods 0.000 title description 30
- 239000007792 gaseous phase Substances 0.000 title description 4
- 101500025132 Bos taurus Ubiquitin Proteins 0.000 claims abstract description 48
- 101500027500 Bos taurus Ubiquitin Proteins 0.000 claims abstract description 48
- 101500027539 Bos taurus Ubiquitin Proteins 0.000 claims abstract description 48
- 101500028979 Bos taurus Ubiquitin Proteins 0.000 claims abstract description 48
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims abstract description 40
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims abstract description 33
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims abstract description 21
- 229960000310 isoleucine Drugs 0.000 claims abstract description 21
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims abstract description 20
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- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 3
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
- G01N27/622—Ion mobility spectrometry
- G01N27/623—Ion mobility spectrometry combined with mass spectrometry
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- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Electrochemistry (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Abstract
La présente invention concerne un procédé de séparation d'ions ayant le même rapport de masse/charge mais des caractéristiques de mobilité d'ions différentes, basé sur les principes de focalisation d'ions de la spectrométrie de mobilité ionique à forme d'onde asymétrique à haute résolution. Les isomères comprenant des anions moléculaires en phase gazeuse des acides aminés leucines et isoleucines sont séparables par le procédé de la présente invention. Le procédé de la présente invention permet également l'identification de différents conformères d'ions dans le même état de charge, notamment des conformères présents dans certains états de charge de la protéine ubiquitine bovine.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002339553A CA2339553C (fr) | 1998-08-05 | 1999-08-05 | Procede de separation d'isomeres et de differentes conformations d'ions en phase gazeuse |
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9548198P | 1998-08-05 | 1998-08-05 | |
US60/095,481 | 1998-08-05 | ||
CA002260572A CA2260572A1 (fr) | 1998-08-05 | 1999-01-29 | Appareil et methode pour piegeage ionique tridimensionnel sous pression atmospherique |
CA2,260,572 | 1999-01-29 | ||
US09/321,820 US6504149B2 (en) | 1998-08-05 | 1999-05-28 | Apparatus and method for desolvating and focussing ions for introduction into a mass spectrometer |
US09/321,820 | 1999-05-28 | ||
CA002339553A CA2339553C (fr) | 1998-08-05 | 1999-08-05 | Procede de separation d'isomeres et de differentes conformations d'ions en phase gazeuse |
PCT/CA1999/000714 WO2000008454A1 (fr) | 1998-08-05 | 1999-08-05 | Procede de separation d'isomeres et de differentes conformations d'ions en phase gazeuse |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2339553A1 CA2339553A1 (fr) | 2000-02-17 |
CA2339553C true CA2339553C (fr) | 2008-11-18 |
Family
ID=27427511
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002339553A Expired - Fee Related CA2339553C (fr) | 1998-08-05 | 1999-08-05 | Procede de separation d'isomeres et de differentes conformations d'ions en phase gazeuse |
Country Status (1)
Country | Link |
---|---|
CA (1) | CA2339553C (fr) |
-
1999
- 1999-08-05 CA CA002339553A patent/CA2339553C/fr not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2339553A1 (fr) | 2000-02-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed | ||
MKLA | Lapsed |
Effective date: 20120806 |
|
MKLA | Lapsed |
Effective date: 20120806 |