CA2337949C - Methods of populating data structures for use in evolutionary simulations - Google Patents

Methods of populating data structures for use in evolutionary simulations Download PDF

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Publication number
CA2337949C
CA2337949C CA2337949A CA2337949A CA2337949C CA 2337949 C CA2337949 C CA 2337949C CA 2337949 A CA2337949 A CA 2337949A CA 2337949 A CA2337949 A CA 2337949A CA 2337949 C CA2337949 C CA 2337949C
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CA
Canada
Prior art keywords
strings
product
initial character
substrings
character strings
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2337949A
Other languages
English (en)
French (fr)
Other versions
CA2337949A1 (en
Inventor
Sergey A. Selifonov
Willem P. C. Stemmer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Codexis Mayflower Holdings LLC
Original Assignee
Maxygen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/408,392 external-priority patent/US6376246B1/en
Priority claimed from US09/408,393 external-priority patent/US6436675B1/en
Priority claimed from US09/484,850 external-priority patent/US6368861B1/en
Priority to CA2721213A priority Critical patent/CA2721213A1/en
Priority claimed from PCT/US2000/001202 external-priority patent/WO2000042560A2/en
Priority claimed from PCT/US2000/001138 external-priority patent/WO2000042559A1/en
Application filed by Maxygen Inc filed Critical Maxygen Inc
Priority claimed from US09/494,282 external-priority patent/US6917882B2/en
Publication of CA2337949A1 publication Critical patent/CA2337949A1/en
Priority claimed from US10/196,473 external-priority patent/US20030054390A1/en
Publication of CA2337949C publication Critical patent/CA2337949C/en
Application granted granted Critical
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • C12N15/1031—Mutagenizing nucleic acids mutagenesis by gene assembly, e.g. assembly by oligonucleotide extension PCR
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B01J2219/00689—Automatic using computers

Landscapes

  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Information Retrieval, Db Structures And Fs Structures Therefor (AREA)
CA2337949A 1999-01-18 2000-01-18 Methods of populating data structures for use in evolutionary simulations Expired - Fee Related CA2337949C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2721213A CA2721213A1 (en) 1999-01-18 2000-01-18 A system for generating labels from sequences of biological molecules

Applications Claiming Priority (24)

Application Number Priority Date Filing Date Title
USPCT/US00/01202 1999-01-18
US09/484,850 1999-01-18
US11644799P 1999-01-19 1999-01-19
US60/116,447 1999-01-19
US11885499P 1999-02-05 1999-02-05
US11881399P 1999-02-05 1999-02-05
US60/118,813 1999-02-05
US60/118,854 1999-02-05
US14104999P 1999-06-24 1999-06-24
US60/141,049 1999-06-24
US09/408,392 US6376246B1 (en) 1999-02-05 1999-09-28 Oligonucleotide mediated nucleic acid recombination
US09/408,392 1999-09-28
US09/408,393 1999-09-28
US09/408,393 US6436675B1 (en) 1999-09-28 1999-09-28 Use of codon-varied oligonucleotide synthesis for synthetic shuffling
US41637599A 1999-10-12 1999-10-12
US41683799A 1999-10-12 1999-10-12
US09/416,375 1999-10-12
US09/416,837 1999-10-12
PCT/US2000/001202 WO2000042560A2 (en) 1999-01-19 2000-01-18 Methods for making character strings, polynucleotides and polypeptides
PCT/US2000/001138 WO2000042559A1 (en) 1999-01-18 2000-01-18 Methods of populating data structures for use in evolutionary simulations
US09/484,850 US6368861B1 (en) 1999-01-19 2000-01-18 Oligonucleotide mediated nucleic acid recombination
US09/494,282 US6917882B2 (en) 1999-01-19 2000-01-18 Methods for making character strings, polynucleotides and polypeptides having desired characteristics
US72160100A 2000-11-21 2000-11-21
US10/196,473 US20030054390A1 (en) 1999-01-19 2002-07-15 Oligonucleotide mediated nucleic acid recombination

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2721213A Division CA2721213A1 (en) 1999-01-18 2000-01-18 A system for generating labels from sequences of biological molecules

Publications (2)

Publication Number Publication Date
CA2337949A1 CA2337949A1 (en) 2000-07-20
CA2337949C true CA2337949C (en) 2011-03-15

Family

ID=43759788

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2337949A Expired - Fee Related CA2337949C (en) 1999-01-18 2000-01-18 Methods of populating data structures for use in evolutionary simulations

Country Status (2)

Country Link
JP (1) JP4899024B2 (ja)
CA (1) CA2337949C (ja)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3289501A4 (en) 2015-05-01 2018-07-11 Schrodinger, LLC Physics-based computational methods for predicting compound solubility
US11208649B2 (en) 2015-12-07 2021-12-28 Zymergen Inc. HTP genomic engineering platform
US9988624B2 (en) 2015-12-07 2018-06-05 Zymergen Inc. Microbial strain improvement by a HTP genomic engineering platform
US11151497B2 (en) * 2016-04-27 2021-10-19 Zymergen Inc. Microbial strain design system and methods for improved large-scale production of engineered nucleotide sequences
CN110957015B (zh) * 2019-12-02 2023-04-28 南开大学 电子医疗记录数据的缺失值填充方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6117679A (en) * 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination

Also Published As

Publication number Publication date
CA2337949A1 (en) 2000-07-20
JP2003536117A (ja) 2003-12-02
JP4899024B2 (ja) 2012-03-21

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