CA2330254A1 - Nutritional assessment by measuring mitochondrial complex activity - Google Patents

Nutritional assessment by measuring mitochondrial complex activity Download PDF

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Publication number
CA2330254A1
CA2330254A1 CA002330254A CA2330254A CA2330254A1 CA 2330254 A1 CA2330254 A1 CA 2330254A1 CA 002330254 A CA002330254 A CA 002330254A CA 2330254 A CA2330254 A CA 2330254A CA 2330254 A1 CA2330254 A1 CA 2330254A1
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CA
Canada
Prior art keywords
complex
mammal
nutritional assessment
activity
mitochondrial complex
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002330254A
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French (fr)
Other versions
CA2330254C (en
Inventor
Khursheed Jeejeebhoy
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Individual
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Individual
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Publication date
Priority claimed from CA002240588A external-priority patent/CA2240588A1/en
Application filed by Individual filed Critical Individual
Priority to CA002330254A priority Critical patent/CA2330254C/en
Publication of CA2330254A1 publication Critical patent/CA2330254A1/en
Application granted granted Critical
Publication of CA2330254C publication Critical patent/CA2330254C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physiology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

According to a first aspect of the invention, a method of detecting malnutrition in a mammal is provided. The method includes the steps of: (a) measuring the activity in the mammal of one or more complexes selected from the group consisting of Complex I, Complex II, and Complex III; and (b) determining if the level of activity is below the level of activity of the complexes in a normal control sample.
According to a second aspect of the invention, the use of Complex I is disclosed for nutritional assessment of a mammal. According to a third aspect of the invention, the use of Complex II is disclosed for nutritional assessment of a mammal. According to a fourth aspect of the invention, the use of Complex III is disclosed for nutritional assessment of a mammal. According to a fifth aspect of the invention, a kit for nutritional assessment of a mammal is provided, comprising one or more reagents for measuring the activity in the mammal of one or more complexes selected from the group consisting of Complex I, Complex II, and Complex III.
CA002330254A 1998-06-12 1999-06-14 Nutritional assessment by measuring mitochondrial complex activity Expired - Fee Related CA2330254C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002330254A CA2330254C (en) 1998-06-12 1999-06-14 Nutritional assessment by measuring mitochondrial complex activity

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CA002240588A CA2240588A1 (en) 1998-06-12 1998-06-12 Nutritional assessment by lymphocyte mitochondrial complex activity
CA2,240,588 1998-06-12
PCT/CA1999/000551 WO1999066064A1 (en) 1998-06-12 1999-06-14 Nutritional assessment by measuring mitochondrial complex activity
CA002330254A CA2330254C (en) 1998-06-12 1999-06-14 Nutritional assessment by measuring mitochondrial complex activity

Publications (2)

Publication Number Publication Date
CA2330254A1 true CA2330254A1 (en) 1999-12-23
CA2330254C CA2330254C (en) 2009-06-23

Family

ID=25680308

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002330254A Expired - Fee Related CA2330254C (en) 1998-06-12 1999-06-14 Nutritional assessment by measuring mitochondrial complex activity

Country Status (1)

Country Link
CA (1) CA2330254C (en)

Also Published As

Publication number Publication date
CA2330254C (en) 2009-06-23

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