CA2323080A1 - Methodes et compositions de developpement selectif de lymphocytes t gamma/delta - Google Patents
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- CA2323080A1 CA2323080A1 CA002323080A CA2323080A CA2323080A1 CA 2323080 A1 CA2323080 A1 CA 2323080A1 CA 002323080 A CA002323080 A CA 002323080A CA 2323080 A CA2323080 A CA 2323080A CA 2323080 A1 CA2323080 A1 CA 2323080A1
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- 238000007920 subcutaneous administration Methods 0.000 description 1
- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 239000003104 tissue culture media Substances 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000002463 transducing effect Effects 0.000 description 1
- 230000026683 transduction Effects 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000005751 tumor progression Effects 0.000 description 1
- 244000052613 viral pathogen Species 0.000 description 1
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Classifications
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- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/208—IL-12
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
- A61K39/4621—Cellular immunotherapy characterized by the effect or the function of the cells immunosuppressive or immunotolerising
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/46434—Antigens related to induction of tolerance to non-self
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2806—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
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- A—HUMAN NECESSITIES
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/54—Interleukins [IL]
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- Health & Medical Sciences (AREA)
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
La présente invention concerne une méthode permettant d'accroître le pourcentage de lymphocytes T gamma-delta dans une population de cellules hématolymphoïdes, lesdits lymphocytes T gamma-delta pouvant survivre sur une durée prolongée, consistant: a) à mettre une population de cellules hématolymphoïdes au contact de l'interleukine 12 et d'un ligand de CD2 induisant la faculté de réponse à l'interleukine 12; et b) à mettre les cellules de l'étape a) au contact d'un anticorps dirigé contre CD3 et l'interleukine-2. La présente invention concerne également une méthode de traitement du cancer ou d'une infection, une méthode favorisant la cicatrisation et facilitant la greffe de moelle osseuse chez un sujet, consistant à administrer au sujet une dose efficace des cellules de l'invention.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7772998P | 1998-03-12 | 1998-03-12 | |
| US60/077,729 | 1998-03-12 | ||
| PCT/US1999/005355 WO1999046365A1 (fr) | 1998-03-12 | 1999-03-12 | Methodes et compositions de developpement selectif de lymphocytes t gamma/delta |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2323080A1 true CA2323080A1 (fr) | 1999-09-16 |
Family
ID=22139725
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002323080A Abandoned CA2323080A1 (fr) | 1998-03-12 | 1999-03-12 | Methodes et compositions de developpement selectif de lymphocytes t gamma/delta |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1062320A4 (fr) |
| AU (1) | AU746531B2 (fr) |
| CA (1) | CA2323080A1 (fr) |
| WO (1) | WO1999046365A1 (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69940352D1 (de) | 1998-11-04 | 2009-03-12 | Therapure Biopharma Inc | Verfahren zur herstellung von gamma delta t zellen |
| WO2000044893A1 (fr) * | 1999-01-28 | 2000-08-03 | Palmetto Health Alliance D/B/A Palmetto Richland Memorial Hospital | Lymphocytes gamma delta actives in vitro |
| US7078034B2 (en) | 1999-01-28 | 2006-07-18 | Palmetto Health Alliance | In vitro activated γ δ lymphocytes |
| DK1231840T3 (da) * | 1999-11-24 | 2009-11-23 | Red Cliff Holding | Anti-angiogent cellulært middel til cancerterapi |
| AU2005239674B2 (en) * | 1999-11-24 | 2009-02-26 | Ernest G Hope | Anti-angiogenic cellular agent for cancer therapy |
| ATE449162T1 (de) * | 2000-04-03 | 2009-12-15 | Therapure Biopharma Inc | Herstellung von tcr gamma delta t-zellen |
| EP3018200A1 (fr) | 2014-11-07 | 2016-05-11 | Fondazione Matilde Tettamanti e Menotti de Machi Onlus | Procédé amélioré pour la production de cellules génétiquement modifiées |
| CN112930187A (zh) | 2018-09-27 | 2021-06-08 | 弗斯弗加姆股份有限公司 | 用于同种异体γ/δ-T细胞的扩增和使用的方法和组合物 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2530966B2 (ja) * | 1992-02-05 | 1996-09-04 | 川澄化学工業株式会社 | 機能的ｔ細胞亜群の高純度大量培養方法 |
| US5639653A (en) * | 1993-07-19 | 1997-06-17 | Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva Universtiy | Method for proliferating Vγ2Vδ2 T cells |
| EP0937258A2 (fr) * | 1996-10-29 | 1999-08-25 | Fred Hutchinson Cancer Research Center, Inc. | Gene de classe i du complexe majeur d'histocompatibilite humain a stress cellulaire regule |
-
1999
- 1999-03-12 WO PCT/US1999/005355 patent/WO1999046365A1/fr not_active Application Discontinuation
- 1999-03-12 EP EP99911325A patent/EP1062320A4/fr not_active Withdrawn
- 1999-03-12 AU AU29992/99A patent/AU746531B2/en not_active Ceased
- 1999-03-12 CA CA002323080A patent/CA2323080A1/fr not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999046365A1 (fr) | 1999-09-16 |
| AU2999299A (en) | 1999-09-27 |
| AU746531B2 (en) | 2002-05-02 |
| EP1062320A4 (fr) | 2003-01-02 |
| EP1062320A1 (fr) | 2000-12-27 |
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