CA2322764A1 - Antagonistes therapeutiques du recepteur de chemokine - Google Patents

Antagonistes therapeutiques du recepteur de chemokine Download PDF

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Publication number
CA2322764A1
CA2322764A1 CA002322764A CA2322764A CA2322764A1 CA 2322764 A1 CA2322764 A1 CA 2322764A1 CA 002322764 A CA002322764 A CA 002322764A CA 2322764 A CA2322764 A CA 2322764A CA 2322764 A1 CA2322764 A1 CA 2322764A1
Authority
CA
Canada
Prior art keywords
cxcr4 antagonist
sdf
cells
cxcr4
mammal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002322764A
Other languages
English (en)
Inventor
Ian Clark-Lewis
Jiang-Hong Gong
Vincent Duronio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of British Columbia
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA002226391A external-priority patent/CA2226391A1/fr
Priority claimed from CA002245224A external-priority patent/CA2245224A1/fr
Application filed by Individual filed Critical Individual
Priority to CA002322764A priority Critical patent/CA2322764A1/fr
Priority claimed from PCT/CA1999/000221 external-priority patent/WO1999047158A2/fr
Publication of CA2322764A1 publication Critical patent/CA2322764A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7158—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for chemokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/522—Alpha-chemokines, e.g. NAP-2, ENA-78, GRO-alpha/MGSA/NAP-3, GRO-beta/MIP-2alpha, GRO-gamma/MIP-2beta, IP-10, GCP-2, MIG, PBSF, PF-4, KC

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne diverses utilisations thérapeutiques des antagonistes de CXCR4. Dans des réalisations diverses, des antagonistes de CXCR4 sont utilisés pour la fabrication de médicaments ou sont utilisés dans les traitements tels que la réduction de la production d'interféron gamma par les cellules T, le traitement d'une maladie auto-immune, le traitement de la sclérose multiple, le traitement du cancer, et l'inhibition de l'angiogénèse. La présente invention concerne aussi les procédés des traitements associés dans lesquels une dose d'un antagoniste de CXCR4 est administrée à l'aide d'une formulation d'usage pharmacologique. Cette invention concerne donc aussi des compositions thérapeutiques qui comprennent un antagoniste de CXCR4 et un excipient ou un support d'usage pharmacologique. Les antagonistes de CXCR4 de l'invention sont des composés de type peptide qui comprennent un fragment peptide sensiblement purifié, un fragment modifié, un analogue ou un sel de SDF-1 acceptable sur le plan pharmacologique.
CA002322764A 1998-03-13 1999-03-12 Antagonistes therapeutiques du recepteur de chemokine Abandoned CA2322764A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002322764A CA2322764A1 (fr) 1998-03-13 1999-03-12 Antagonistes therapeutiques du recepteur de chemokine

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
CA002226391A CA2226391A1 (fr) 1998-03-13 1998-03-13 Peptides n-terminaux du sdf-1 ayant des activites fonctionnelles facilitees par cxcr4
CA002245224A CA2245224A1 (fr) 1998-08-14 1998-08-14 Antagonistes du recepteur de la chimiokine et chimiotherapie
CA2,226,391 1998-08-14
CA2,245,224 1998-08-14
PCT/CA1999/000221 WO1999047158A2 (fr) 1998-03-13 1999-03-12 Antagonistes therapeutiques du recepteur de chemokine
CA002322764A CA2322764A1 (fr) 1998-03-13 1999-03-12 Antagonistes therapeutiques du recepteur de chemokine

Publications (1)

Publication Number Publication Date
CA2322764A1 true CA2322764A1 (fr) 1999-09-23

Family

ID=27170596

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002322764A Abandoned CA2322764A1 (fr) 1998-03-13 1999-03-12 Antagonistes therapeutiques du recepteur de chemokine

Country Status (1)

Country Link
CA (1) CA2322764A1 (fr)

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued