CA2311784A1 - Use of fluorinated solvents for the formulation of hair lotions - Google Patents
Use of fluorinated solvents for the formulation of hair lotions Download PDFInfo
- Publication number
- CA2311784A1 CA2311784A1 CA002311784A CA2311784A CA2311784A1 CA 2311784 A1 CA2311784 A1 CA 2311784A1 CA 002311784 A CA002311784 A CA 002311784A CA 2311784 A CA2311784 A CA 2311784A CA 2311784 A1 CA2311784 A1 CA 2311784A1
- Authority
- CA
- Canada
- Prior art keywords
- hair
- lotions
- formulation
- hair lotions
- fluorinated solvents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/69—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing fluorine
- A61K8/70—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing fluorine containing perfluoro groups, e.g. perfluoroethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
- A61K8/315—Halogenated hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
Abstract
The invention concerns a hair lotion characterised in that it contains a solventn consisting of at least a hydrofluoroether of general formula (I) CnHmF2n+1-m-O-CpHqF2p+1-q in which n = 1 to 20; m = 0 to 2n+1; p = 1 to 20; q = 0 to 2p+1.
Description
Use of fluorinated solvents for the formulation of hair lotions The invention relates to the field of the cosmetic a n d pharmaceutical industry.
More precisely, the invention relates to hair lotions for cosmetic or pharmaceutical use.
Hair lotions are generally employed to stimulate the hair, remove dandruff and other impurities from the scalp, and to remove excess sebum secreted by the scalp. Certain hair lotions can also be used for therapeutic purposes. These lotions generally have specific actions.
Their formulation generally includes:
- a vehicle, most often made up of 30 to 50° ethanol, chosen for its antiseptic properties and its ability to rapidly evaporate;
- emollients, such as, for example, castor oil and its derivatives, which compensate for the dehydrating effect of t h a ethanol;
- coating polymers that make arranging one's hair easier;
- active anti-sebum, anti-dandruff, overgreasing o r pharmaceutic substances.
Lotions intended to prevent hair loss may, in addition contain:
More precisely, the invention relates to hair lotions for cosmetic or pharmaceutical use.
Hair lotions are generally employed to stimulate the hair, remove dandruff and other impurities from the scalp, and to remove excess sebum secreted by the scalp. Certain hair lotions can also be used for therapeutic purposes. These lotions generally have specific actions.
Their formulation generally includes:
- a vehicle, most often made up of 30 to 50° ethanol, chosen for its antiseptic properties and its ability to rapidly evaporate;
- emollients, such as, for example, castor oil and its derivatives, which compensate for the dehydrating effect of t h a ethanol;
- coating polymers that make arranging one's hair easier;
- active anti-sebum, anti-dandruff, overgreasing o r pharmaceutic substances.
Lotions intended to prevent hair loss may, in addition contain:
- vasodilatory compounds, such as, for example, extracts of capsicum, cinchona or nicotinic esters;
- biological extracts such as, for example, placental derivatives, amniotic liquid, mucopolysaccharides;
- panthenol or derived ethers (pantothenyl- ethyl ether) which would be factors for the growth of hair;
- amino-acids - vitamin complexes.
Perfume substances, such as camphor or essential oils, colorants as well as stabilizers (anti-oxidants, pH correctors) can complement the basic composition of such hair lotions.
These lotions are generally presented in the form of a single phase or two phase liquid system. In the case of single phase systems, the various constituents of the lotion are dissolved or dispersed in water or in a water-alcohol mixture.
In the case of lotions with two liquid phases, de-odorized light petroleum is added to the formulation. This particular feature enables one to add various lipophilic constituents sparingly soluble in the water/alcohol phase. The immiscibility of the light petroleum and the water or water/alcohol solutions leads to the formation of the two liquid phases.
As has already been made clear above, ethanol which i s generally used as a vehicle in hair lotions, leads to a certain number of disadvantages.
Hence, when present at high concentrations (30 to 50%), i t has a dehydrating action on the scalp which can lead to skin irritation. This aggressive effect must be neutralized by t h a addition of an emollient to the formulation.
Daily use of hair lotions containing alcohol leads to absorption of the alcohol through the skin, sometimes in large quantities. For obvious health reasons, this absorption of alcohol must be avoided.
Furthermore, certain religions condemn the absorption of alcohol, whether it be by oral consumption or absorption 3 5 through the skin and therefore the use of perfumes a n d cosmetic products containing alcohol is forbidden to people practising these religions.
It should also be noted that the quantities of alcohol a n d petroleum in hair lotions are sufficiently large to lead to acute intoxication when such lotions are accidentally ingested, i n particular by young children.
The light petroleum fractions, also frequently used in t h a hair lotion formulations also have recognized toxicity. On frequent or prolonged contact with the skin, light petroleum fractions destroy the lipo-acid cutaneous coating and can cause dermatosis of variable seriousness with the risk of secondary allergy. The vapor is an irritant for mucous membranes. A t high concentration, they exert a narcotic action on the central nervous system (headaches, dizziness, somnolence). Certain light petroleum products, officially called petroleum spirit A, petroleum spirit B and petroleum spirit C, have vapors rich i n hexane and have been the source of serious polyneuritis, particularly in Japan and in certain European countries such a s France. Accidental ingestion of these petroleum spirits a re capable of causing serious hepato-digestive attacks and sometimes nervous troubles (coma, respiratory incidents) with serious prognoses. In addition, the possible presence of benzene in these solvents can have hematological implications.
The objective of this invention is to propose hair lotions which do not contain ethanol.
Another objective of this invention is to permit the manufacture of such lotions which also do not contain any light petroleum spirit.
These objectives are achieved thanks to the invention which relates to a hair lotion characterized in that it contains a solvent constituted by at least one totally or partially fluorinated hydrocarbon of general formula (I) CnHmF2n+1-m-~-CpHqF2p+1-9 inwhichn=1to20;m=Oto2n+l;p=1to20;q=Oto2p+1.
- biological extracts such as, for example, placental derivatives, amniotic liquid, mucopolysaccharides;
- panthenol or derived ethers (pantothenyl- ethyl ether) which would be factors for the growth of hair;
- amino-acids - vitamin complexes.
Perfume substances, such as camphor or essential oils, colorants as well as stabilizers (anti-oxidants, pH correctors) can complement the basic composition of such hair lotions.
These lotions are generally presented in the form of a single phase or two phase liquid system. In the case of single phase systems, the various constituents of the lotion are dissolved or dispersed in water or in a water-alcohol mixture.
In the case of lotions with two liquid phases, de-odorized light petroleum is added to the formulation. This particular feature enables one to add various lipophilic constituents sparingly soluble in the water/alcohol phase. The immiscibility of the light petroleum and the water or water/alcohol solutions leads to the formation of the two liquid phases.
As has already been made clear above, ethanol which i s generally used as a vehicle in hair lotions, leads to a certain number of disadvantages.
Hence, when present at high concentrations (30 to 50%), i t has a dehydrating action on the scalp which can lead to skin irritation. This aggressive effect must be neutralized by t h a addition of an emollient to the formulation.
Daily use of hair lotions containing alcohol leads to absorption of the alcohol through the skin, sometimes in large quantities. For obvious health reasons, this absorption of alcohol must be avoided.
Furthermore, certain religions condemn the absorption of alcohol, whether it be by oral consumption or absorption 3 5 through the skin and therefore the use of perfumes a n d cosmetic products containing alcohol is forbidden to people practising these religions.
It should also be noted that the quantities of alcohol a n d petroleum in hair lotions are sufficiently large to lead to acute intoxication when such lotions are accidentally ingested, i n particular by young children.
The light petroleum fractions, also frequently used in t h a hair lotion formulations also have recognized toxicity. On frequent or prolonged contact with the skin, light petroleum fractions destroy the lipo-acid cutaneous coating and can cause dermatosis of variable seriousness with the risk of secondary allergy. The vapor is an irritant for mucous membranes. A t high concentration, they exert a narcotic action on the central nervous system (headaches, dizziness, somnolence). Certain light petroleum products, officially called petroleum spirit A, petroleum spirit B and petroleum spirit C, have vapors rich i n hexane and have been the source of serious polyneuritis, particularly in Japan and in certain European countries such a s France. Accidental ingestion of these petroleum spirits a re capable of causing serious hepato-digestive attacks and sometimes nervous troubles (coma, respiratory incidents) with serious prognoses. In addition, the possible presence of benzene in these solvents can have hematological implications.
The objective of this invention is to propose hair lotions which do not contain ethanol.
Another objective of this invention is to permit the manufacture of such lotions which also do not contain any light petroleum spirit.
These objectives are achieved thanks to the invention which relates to a hair lotion characterized in that it contains a solvent constituted by at least one totally or partially fluorinated hydrocarbon of general formula (I) CnHmF2n+1-m-~-CpHqF2p+1-9 inwhichn=1to20;m=Oto2n+l;p=1to20;q=Oto2p+1.
Such fluorinated solvents offer crucial advantages compared to traditional organic solvents such as ethanol, used in the formulation of hair lotions of the state of the technology.
In the first place, they are atoxic. Various toxicological studies notably concerned with perfluorinated alkanes and perfluorinated N-methyl morpholine have been carried out on rodents. These studies have demonstrated oral atoxicity even for doses as high as 10 g/kg, for point administration, or 2 g/kg/day for 4 weeks. The perfluorinated N-methyl morpholine produces, at doses of 0,1 ml, a slight reversible irritation of the ocular conjunctive tissues but without corneal damage. On the other hand, under the same conditions, t h a fluorinated alkanes do not cause any ocular irritation.
Furthermore, no skin irritation is observed for localized applications of 0.5 ml of fluorinated solvent.
Therefore, at the present time, there is no toxicological contra-indication whatsoever for the fluorinated solvents proposed by the invention for use in the context of hair lotions.
The fluorinated solvents proposed by the invention are i n addition without odor or only have a slight odor. Therefore they can be integrated into hair lotion formulations without risk of masking possible perfumes.
Furthermore, it should also be noted that these fluorinated solvents are lipophilic compounds. Hence they are capable, on the one hand, of solubilizing the lipophilic constituents in the formulations and, on the other hand of contributing to the removal of sebum.
In addition, these fluorinated solvents are of interest since they are chemically inert and do not react with any of t h a usual constituents of cosmetic formulations. They are volatile compounds which, after evaporation, leave no trace whatsoever.
Finally, they do not present any risk to the ecosystem.
According to a preferred variant, said solvent is chosen from the group constituted by methyl-perfluorobutyl ether, perfluorinated octane and perfluorinated nonane.
It will be understood that the hair lotions according to the 5 invention will include a fluorinated compound as described above or a mixture of such fluorinated compounds.
The invention will be more easily understood from t h a description that follows of non-limitative embodiments of it.
Example 1 The deodorized light petroleum of a commercial hair lotion is replaced by a mixture of 50% (v/v) of mathyl-perfluorobutyl ether (CH3-O-C4F9 with n = 1, m = 3, p = 4 and q - 0), 25% (v/v) of perfluorinated octane and 25% (v/v) of perfluorinated nonane.
The methyl-perfluorobutyl ether enables the perfume substances to be easily solubilized. The perfluorinated octane and nonane are used because their volatility is less than that of methyl-perfluorobutyl ether. They prevent to rapid a n evaporation of the organic phase when the lotion is being applied and enable the refreshing sensation that is a consequence of evaporation, to last longer.
Example 2 One volume of a mixture of 50% (v/v) ethyl perfluorobutyl ether (C2H5-O-C4F9 with n = 2, m = 5, p = 4 and q = 0) and 50% (v/v) perfluoro-octane is added to eight volumes of an aqueous solution containing water soluble active ingredients necessary for hair care. 0.1% (v/v) of a mixture of essential oils of cypress, the tea tree, chamomile and lavender, intended to perfume the composition and to provide 3 0 complementary hair care, is added to this mixture.
Example 3 One volume of a mixture of 50% (v/v) propyl-perfluorobutyl ether (C3H7-O-C4F9 with n = 3, m = 7, p = 4 and q = 0) and 50% (v/v) perfluoro-octane is added to eight volumes of an aqueous solution containing water soluble active ingredients necessary for hair care. 0.1% (v/v) of a mixture of essential oils of cypress, the tea tree, chamomile and lavender, intended to perfume the composition and to provide complementary hair care, is added to this mixture.
In the first place, they are atoxic. Various toxicological studies notably concerned with perfluorinated alkanes and perfluorinated N-methyl morpholine have been carried out on rodents. These studies have demonstrated oral atoxicity even for doses as high as 10 g/kg, for point administration, or 2 g/kg/day for 4 weeks. The perfluorinated N-methyl morpholine produces, at doses of 0,1 ml, a slight reversible irritation of the ocular conjunctive tissues but without corneal damage. On the other hand, under the same conditions, t h a fluorinated alkanes do not cause any ocular irritation.
Furthermore, no skin irritation is observed for localized applications of 0.5 ml of fluorinated solvent.
Therefore, at the present time, there is no toxicological contra-indication whatsoever for the fluorinated solvents proposed by the invention for use in the context of hair lotions.
The fluorinated solvents proposed by the invention are i n addition without odor or only have a slight odor. Therefore they can be integrated into hair lotion formulations without risk of masking possible perfumes.
Furthermore, it should also be noted that these fluorinated solvents are lipophilic compounds. Hence they are capable, on the one hand, of solubilizing the lipophilic constituents in the formulations and, on the other hand of contributing to the removal of sebum.
In addition, these fluorinated solvents are of interest since they are chemically inert and do not react with any of t h a usual constituents of cosmetic formulations. They are volatile compounds which, after evaporation, leave no trace whatsoever.
Finally, they do not present any risk to the ecosystem.
According to a preferred variant, said solvent is chosen from the group constituted by methyl-perfluorobutyl ether, perfluorinated octane and perfluorinated nonane.
It will be understood that the hair lotions according to the 5 invention will include a fluorinated compound as described above or a mixture of such fluorinated compounds.
The invention will be more easily understood from t h a description that follows of non-limitative embodiments of it.
Example 1 The deodorized light petroleum of a commercial hair lotion is replaced by a mixture of 50% (v/v) of mathyl-perfluorobutyl ether (CH3-O-C4F9 with n = 1, m = 3, p = 4 and q - 0), 25% (v/v) of perfluorinated octane and 25% (v/v) of perfluorinated nonane.
The methyl-perfluorobutyl ether enables the perfume substances to be easily solubilized. The perfluorinated octane and nonane are used because their volatility is less than that of methyl-perfluorobutyl ether. They prevent to rapid a n evaporation of the organic phase when the lotion is being applied and enable the refreshing sensation that is a consequence of evaporation, to last longer.
Example 2 One volume of a mixture of 50% (v/v) ethyl perfluorobutyl ether (C2H5-O-C4F9 with n = 2, m = 5, p = 4 and q = 0) and 50% (v/v) perfluoro-octane is added to eight volumes of an aqueous solution containing water soluble active ingredients necessary for hair care. 0.1% (v/v) of a mixture of essential oils of cypress, the tea tree, chamomile and lavender, intended to perfume the composition and to provide 3 0 complementary hair care, is added to this mixture.
Example 3 One volume of a mixture of 50% (v/v) propyl-perfluorobutyl ether (C3H7-O-C4F9 with n = 3, m = 7, p = 4 and q = 0) and 50% (v/v) perfluoro-octane is added to eight volumes of an aqueous solution containing water soluble active ingredients necessary for hair care. 0.1% (v/v) of a mixture of essential oils of cypress, the tea tree, chamomile and lavender, intended to perfume the composition and to provide complementary hair care, is added to this mixture.
Claims (4)
1. Hair lotion characterized in that it contains a solvent consisting of at least one hydrofluoro ether of general formula (I):
C n H m F2n+1-m-O-C p H q F2p+1-q in which n = 1 to 20, m = 0 to 2n + 1; p = 1 to 20; q = 0 to 2p+1.
C n H m F2n+1-m-O-C p H q F2p+1-q in which n = 1 to 20, m = 0 to 2n + 1; p = 1 to 20; q = 0 to 2p+1.
2. Lotion according to Claim 1, characterized in that said solvent contains methyl-perfluorobutyl ether.
3. Lotion according to Claim 1, characterized in that said solvent contains ethyl-perfluorobutyl ether.
4. Lotion according to Claim 1, characterized in that said solvent contains propyl-perfluorobutyl ether.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR97/15118 | 1997-11-26 | ||
FR9715118A FR2771287B1 (en) | 1997-11-26 | 1997-11-26 | USE OF FLUORINATED SOLVENTS FOR THE FORMULATION OF HAIR CARE LOTIONS |
PCT/FR1998/002545 WO1999026594A1 (en) | 1997-11-26 | 1998-11-26 | Use of fluorinated solvents for the formulation of hair lotions |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2311784A1 true CA2311784A1 (en) | 1999-06-03 |
Family
ID=9514025
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002311784A Abandoned CA2311784A1 (en) | 1997-11-26 | 1998-11-26 | Use of fluorinated solvents for the formulation of hair lotions |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1032357A1 (en) |
JP (1) | JP2001523698A (en) |
AU (1) | AU748913B2 (en) |
CA (1) | CA2311784A1 (en) |
FR (1) | FR2771287B1 (en) |
WO (1) | WO1999026594A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20120230935A1 (en) * | 2011-03-08 | 2012-09-13 | Somang Cosmetics Co., Ltd. | Solvent composition for one-step permanent wave and hair straightener |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2795641A1 (en) * | 1999-07-01 | 2001-01-05 | Oreal | USE OF VOLATILE FLUORINATED OIL FOR BLASTING IMPERFECTIONS AND MATTIFYING THE SKIN, AND COSMETIC TREATMENT METHOD USING SAID VOLATILE FLUORINATED OIL |
FR2811891A1 (en) * | 2000-07-21 | 2002-01-25 | Oreal | Refreshing aerosol composition for cosmetic or dermatological use includes propulsion agent of non- hydrofluorocarbon or hydrofluorocarbon type, and fluorine compound such as perfluoropentane |
DE10302190A1 (en) * | 2003-01-20 | 2004-07-29 | Hans Schwarzkopf & Henkel Gmbh & Co. Kg | Sprayable three-phase composition useful for hair styling and for producing shine on the hair comprises an aqueous phase, an oil phase and a phase comprising a trifunctional ester |
EP2477486A4 (en) | 2009-09-16 | 2012-09-26 | Living Proof Inc | Cationic alcohols and uses thereof |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9109693D0 (en) * | 1991-05-03 | 1991-06-26 | Unilever Plc | Hair treatment composition |
FR2688006A1 (en) * | 1992-02-27 | 1993-09-03 | Oreal | DISPERSION OF FLUORINATED HYDROCARBON IN AQUEOUS SOLUTION OF A FILMOGENIC POLYMER AND USE THEREOF FOR THE FORMATION OF COMPOSITE FILMS, ESPECIALLY IN COSMETICS. |
GB9204509D0 (en) * | 1992-03-02 | 1992-04-15 | Unilever Plc | Hair care composition |
US5667772A (en) * | 1992-10-29 | 1997-09-16 | Lancaster Group Ag | Preparation containing a fluorocarbon emulsion and usable as cosmetics or dermatics |
JP3211740B2 (en) | 1997-08-28 | 2001-09-25 | ダイキン工業株式会社 | Cosmetics |
-
1997
- 1997-11-26 FR FR9715118A patent/FR2771287B1/en not_active Expired - Fee Related
-
1998
- 1998-11-26 JP JP2000521797A patent/JP2001523698A/en active Pending
- 1998-11-26 CA CA002311784A patent/CA2311784A1/en not_active Abandoned
- 1998-11-26 WO PCT/FR1998/002545 patent/WO1999026594A1/en not_active Application Discontinuation
- 1998-11-26 EP EP98956964A patent/EP1032357A1/en not_active Withdrawn
- 1998-11-26 AU AU13411/99A patent/AU748913B2/en not_active Ceased
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20120230935A1 (en) * | 2011-03-08 | 2012-09-13 | Somang Cosmetics Co., Ltd. | Solvent composition for one-step permanent wave and hair straightener |
Also Published As
Publication number | Publication date |
---|---|
FR2771287B1 (en) | 2000-11-03 |
FR2771287A1 (en) | 1999-05-28 |
WO1999026594A1 (en) | 1999-06-03 |
AU1341199A (en) | 1999-06-15 |
EP1032357A1 (en) | 2000-09-06 |
AU748913B2 (en) | 2002-06-13 |
JP2001523698A (en) | 2001-11-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |