CA2301064A1 - Dispositifs prothetiques implantables enrobes de molecules bioactives - Google Patents

Dispositifs prothetiques implantables enrobes de molecules bioactives Download PDF

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Publication number
CA2301064A1
CA2301064A1 CA002301064A CA2301064A CA2301064A1 CA 2301064 A1 CA2301064 A1 CA 2301064A1 CA 002301064 A CA002301064 A CA 002301064A CA 2301064 A CA2301064 A CA 2301064A CA 2301064 A1 CA2301064 A1 CA 2301064A1
Authority
CA
Canada
Prior art keywords
gold
peptide
layer
molecule
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002301064A
Other languages
English (en)
Inventor
Robert F. Valentini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brown University Research Foundation Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2301064A1 publication Critical patent/CA2301064A1/fr
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A61L33/12—Polypeptides, proteins or derivatives thereof, e.g. degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/30—Inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/30—Inorganic materials
    • A61L27/306—Other specific inorganic materials not covered by A61L27/303 - A61L27/32
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L89/00—Compositions of proteins; Compositions of derivatives thereof

Abstract

L'invention concerne des dispositifs prothétiques implantables enrobés. Le dispositif est une prothèse, dont la surface est recouverte d'une couche d'or, à laquelle sont liées des molécules bioactives au moyen d'une liaison or-sulfhydryle. Ces dispositifs sont faciles et commodes à préparer. L'invention concerne également des dispositifs implantables recouverts d'or. Le dispositif implantable recouvert d'or est un dispositif prothétique en matériau poreux non-tissulaire, dont la surface présente des saillies et des creux. La couche d'or qui recouvre la surface du matériau poreux non-tissulaire forme une couche uniforme sur tout le matériau, de sorte que la couche d'or forme également des saillies et des creux.
CA002301064A 1997-07-01 1998-07-01 Dispositifs prothetiques implantables enrobes de molecules bioactives Abandoned CA2301064A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5143997P 1997-07-01 1997-07-01
US60/051,439 1997-07-01
PCT/US1998/013792 WO1999001089A1 (fr) 1997-07-01 1998-07-01 Dispositifs prothetiques implantables enrobes de molecules bioactives

Publications (1)

Publication Number Publication Date
CA2301064A1 true CA2301064A1 (fr) 1999-01-14

Family

ID=21971332

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002301064A Abandoned CA2301064A1 (fr) 1997-07-01 1998-07-01 Dispositifs prothetiques implantables enrobes de molecules bioactives

Country Status (3)

Country Link
EP (1) EP1006945A1 (fr)
CA (1) CA2301064A1 (fr)
WO (1) WO1999001089A1 (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001056627A1 (fr) * 2000-01-12 2001-08-09 Am-Pharma B.V. Dispositif medical revetu de peptides antimicrobiens
CH695985A5 (de) * 2002-01-21 2006-11-15 Straumann Holding Ag Oberflächenmodifizierte Implantate.
GB0208642D0 (en) * 2002-04-16 2002-05-22 Accentus Plc Metal implants
EP2447055B1 (fr) 2002-06-24 2017-12-06 Tufts University Biomatériaux en soie et leurs procédés d'utilisation
WO2004062697A2 (fr) 2003-01-07 2004-07-29 Tufts University Matières de fibroïne de soie et utilisation de celles-ci
EP1613796B1 (fr) 2003-04-10 2017-03-22 Tufts University Solution aqueuse concentree de fibroine et utilisation
WO2005000483A1 (fr) 2003-06-06 2005-01-06 Tufts University Procede de formation d'enrobages inorganiques
GB0405680D0 (en) 2004-03-13 2004-04-21 Accentus Plc Metal implants
JP2010522583A (ja) 2007-02-27 2010-07-08 トラスティーズ オブ タフツ カレッジ 組織工学的に作製された絹製臓器
PL2211876T3 (pl) 2007-05-29 2015-05-29 Tufts College Sposób żelowania fibroiny jedwabiu z użyciem sonikacji
EP2018864A1 (fr) 2007-07-23 2009-01-28 Biomet Deutschland GmbH Composition pharmaceutique, substrat comprenant une composition pharmaceutique et utilisation d'une composition pharmaceutique
EP2198076B1 (fr) 2007-10-03 2016-03-16 Accentus Medical Limited Procédé de fabrication d'un métal à propriétés biocides
CN101970023A (zh) 2008-02-07 2011-02-09 塔夫茨大学信托人 三维的丝羟基磷灰石组合物
US9040073B2 (en) 2008-05-15 2015-05-26 Trustees Of Tufts College Silk polymer-based adenosine release: therapeutic potential for epilepsy
US8501172B2 (en) 2008-09-26 2013-08-06 Trustees Of Tufts College pH-induced silk gels and uses thereof
KR20110094277A (ko) 2008-10-09 2011-08-23 트러스티즈 오브 터프츠 칼리지 글리세롤을 함유하는 변성 실크 필름
WO2011008842A2 (fr) 2009-07-14 2011-01-20 Trustees Of Tufts College Systèmes de matériau de soie électrofilée pour cicatrisation
EP2483460B1 (fr) 2009-09-28 2015-09-02 Trustees Of Tufts College Procédé de préparation de fibres de soie électrogélifiées étirées
EP2483199B1 (fr) 2009-09-29 2017-04-26 Trustees Of Tufts College Nanosphères et microsphères de soie et leurs procédés de fabrication
WO2011109691A2 (fr) 2010-03-05 2011-09-09 Trustees Of Tufts College Compositions ionomères à base de soie
JP6081358B2 (ja) 2010-09-01 2017-02-15 トラスティーズ・オブ・タフツ・カレッジＴｒｕｓｔｅｅｓ Ｏｆ Ｔｕｆｔｓ Ｃｏｌｌｅｇｅ 絹フィブロインおよびポリエチレングリコールをベースとする生体材料
US10933173B2 (en) 2010-10-19 2021-03-02 Trustees Of Tufts College Silk fibroin-based microneedles and methods of making the same
WO2012145652A1 (fr) 2011-04-20 2012-10-26 Trustees Of Tufts College Revêtements de soie dynamiques pour dispositifs implantables
WO2013119551A1 (fr) 2012-02-06 2013-08-15 Children's Medical Center Corporation Biomatériau multicouche destiné à la régénération de tissus et la cicatrisation de plaies

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5464438A (en) * 1988-10-05 1995-11-07 Menaker; Gerald J. Gold coating means for limiting thromboses in implantable grafts
US5225064A (en) * 1992-01-15 1993-07-06 Enzyme Technology Research Group, Inc. Peroxidase colloidal gold oxidase biosensors for mediatorless glucose determination
EP0741585A1 (fr) * 1994-01-21 1996-11-13 Brown University Research Foundation Implants biocompatibles
US5607442A (en) * 1995-11-13 1997-03-04 Isostent, Inc. Stent with improved radiopacity and appearance characteristics

Also Published As

Publication number Publication date
WO1999001089A1 (fr) 1999-01-14
EP1006945A1 (fr) 2000-06-14

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