CA2300806A1 - Dexamethasone gel - Google Patents

Dexamethasone gel Download PDF

Info

Publication number
CA2300806A1
CA2300806A1 CA002300806A CA2300806A CA2300806A1 CA 2300806 A1 CA2300806 A1 CA 2300806A1 CA 002300806 A CA002300806 A CA 002300806A CA 2300806 A CA2300806 A CA 2300806A CA 2300806 A1 CA2300806 A1 CA 2300806A1
Authority
CA
Canada
Prior art keywords
gel
dexamethasone
preparation
dexamethasone gel
viscosity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002300806A
Other languages
French (fr)
Other versions
CA2300806C (en
Inventor
Gunther Bellmann
Gudrun Claus-Herz
Christoph Kessler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dr Gerhard Mann Chem Pharm Fabrik GmbH
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2300806A1 publication Critical patent/CA2300806A1/en
Application granted granted Critical
Publication of CA2300806C publication Critical patent/CA2300806C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention relates to an ophthalmological preparation containing dexamethasone dihydrogenphosphate disodium as the active ingredient and, optionally, also containing the usual additives and water, which is characterized by a content of at least one gel-forming pharmacologically acceptable substance in a quantity sufficient for adjusting the viscosity of the preparation as a gel.
CA002300806A 1997-10-06 1998-10-05 Dexamethasone gel Expired - Lifetime CA2300806C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19744113.0 1997-10-06
DE19744113A DE19744113A1 (en) 1997-10-06 1997-10-06 Ophthalmological dexamethasone preparation
PCT/EP1998/006339 WO1999017780A1 (en) 1997-10-06 1998-10-05 Dexamethasone gel

Publications (2)

Publication Number Publication Date
CA2300806A1 true CA2300806A1 (en) 1999-04-15
CA2300806C CA2300806C (en) 2004-02-03

Family

ID=7844743

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002300806A Expired - Lifetime CA2300806C (en) 1997-10-06 1998-10-05 Dexamethasone gel

Country Status (18)

Country Link
EP (1) EP1021192B1 (en)
JP (1) JP4156793B2 (en)
KR (1) KR100392481B1 (en)
CN (1) CN1142782C (en)
AR (1) AR017170A1 (en)
AT (1) ATE230601T1 (en)
BR (1) BR9812849A (en)
CA (1) CA2300806C (en)
DE (2) DE19744113A1 (en)
DK (1) DK1021192T3 (en)
ES (1) ES2191352T3 (en)
HK (1) HK1030748A1 (en)
HU (1) HU224986B1 (en)
IL (1) IL135001A0 (en)
MX (1) MXPA00003363A (en)
PL (1) PL189727B1 (en)
WO (1) WO1999017780A1 (en)
ZA (1) ZA989066B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200808375A (en) 2006-05-12 2008-02-16 Otsuka Pharma Co Ltd Hydrogel suspension and manufacturing process thereof
CN101190177B (en) * 2006-11-24 2010-09-01 上海医药工业研究院 Dectancyl partial film forming gel composition and uses thereof
US20150190407A1 (en) * 2014-01-07 2015-07-09 Insite Vision Incorporated Methods for treatment of postoperative inflammation with reduced intraocular pressure

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2212392C3 (en) * 1972-03-15 1981-03-19 Avicon Inc., Fort Worth, Tex. Use of microcrystalline collagen for the manufacture of an aqueous pharmaceutical composition for topical application to the eye
JPS6056684B2 (en) * 1977-11-07 1985-12-11 東興薬品工業株式会社 eye drops
US4271143A (en) * 1978-01-25 1981-06-02 Alcon Laboratories, Inc. Sustained release ophthalmic drug dosage
ATE6466T1 (en) * 1979-10-26 1984-03-15 Smith And Nephew Associated Companies P.L.C. AUTOCLAVABLE EMULSIONS.
JPS63174924A (en) * 1987-01-14 1988-07-19 Toko Yakuhin Kogyo Kk Ointment base and ointment
US5252318A (en) * 1990-06-15 1993-10-12 Allergan, Inc. Reversible gelation compositions and methods of use
EP0551626A1 (en) * 1991-12-19 1993-07-21 LEK, tovarna farmacevtskih in kemicnih izdelkov, d.d. Thermoreversible gel as a liquid pharmaceutical carrier for a galenic formulation
WO1993017664A1 (en) * 1992-03-02 1993-09-16 Alcon Laboratories, Inc. Combinations of cellulosic polymers and carboxy vinyl polymers and their use in pharmaceutical compositions
DE4209722C3 (en) * 1992-03-25 1997-06-19 Medproject Pharma Entwicklungs Dripable gel for ophthalmology
WO1995005803A1 (en) * 1993-08-20 1995-03-02 Alcon Laboratories, Inc. Topical ophthalmic pharmaceutical vehicles
DE4404990C1 (en) * 1994-02-17 1995-05-04 Mann Gerhard Chem Pharm Fab Process for producing a sterile prednisolone gel
US5683993A (en) * 1995-06-22 1997-11-04 Ciba Vision Corporation Compositions and methods for stabilizing polymers
DE19614823A1 (en) * 1996-04-15 1997-10-16 Mann Gerhard Chem Pharm Fab Ophthalmic composition with prolonged retention time on the eye

Also Published As

Publication number Publication date
DK1021192T3 (en) 2003-05-05
ATE230601T1 (en) 2003-01-15
DE59806884D1 (en) 2003-02-13
DE19744113A1 (en) 1999-04-15
JP4156793B2 (en) 2008-09-24
KR100392481B1 (en) 2003-07-23
HUP0003796A2 (en) 2001-04-28
IL135001A0 (en) 2001-05-20
HUP0003796A3 (en) 2001-05-28
HK1030748A1 (en) 2001-05-18
JP2001518510A (en) 2001-10-16
WO1999017780A1 (en) 1999-04-15
PL189727B1 (en) 2005-09-30
PL341026A1 (en) 2001-03-26
EP1021192B1 (en) 2003-01-08
WO1999017780A8 (en) 2000-01-27
EP1021192A1 (en) 2000-07-26
ES2191352T3 (en) 2003-09-01
KR20010030939A (en) 2001-04-16
MXPA00003363A (en) 2007-12-07
CN1266369A (en) 2000-09-13
ZA989066B (en) 1999-06-15
BR9812849A (en) 2000-08-08
HU224986B1 (en) 2006-05-29
CN1142782C (en) 2004-03-24
CA2300806C (en) 2004-02-03
AR017170A1 (en) 2001-08-22

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Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20181005