CA2299396A1 - Procede permettant de preparer des steroides 16.alpha.,17.alpha.-dialkyles - Google Patents

Procede permettant de preparer des steroides 16.alpha.,17.alpha.-dialkyles Download PDF

Info

Publication number
CA2299396A1
CA2299396A1 CA002299396A CA2299396A CA2299396A1 CA 2299396 A1 CA2299396 A1 CA 2299396A1 CA 002299396 A CA002299396 A CA 002299396A CA 2299396 A CA2299396 A CA 2299396A CA 2299396 A1 CA2299396 A1 CA 2299396A1
Authority
CA
Canada
Prior art keywords
group
alkyl
alpha
silyl ether
cleaving agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002299396A
Other languages
English (en)
Inventor
Raymond E. Conrow
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Vision LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2299396A1 publication Critical patent/CA2299396A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

Pour préparer des stéroïdes 16.alpha.,17.alpha.-dialkylés, on fait réagir un 16.alpha.-alkyl-17-(20)-ényl-20-silyléther avec un agent alkylant et un agent de clivage de l'énolsilyléther dans un solvant approprié.
CA002299396A 1997-12-02 1998-11-05 Procede permettant de preparer des steroides 16.alpha.,17.alpha.-dialkyles Abandoned CA2299396A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6714897P 1997-12-02 1997-12-02
US60/067,148 1997-12-02
PCT/US1998/023641 WO1999028336A1 (fr) 1997-12-02 1998-11-05 PROCEDE PERMETTANT DE PREPARER DES STEROIDES 16α,17α-DIALKYLES

Publications (1)

Publication Number Publication Date
CA2299396A1 true CA2299396A1 (fr) 1999-06-10

Family

ID=22074020

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002299396A Abandoned CA2299396A1 (fr) 1997-12-02 1998-11-05 Procede permettant de preparer des steroides 16.alpha.,17.alpha.-dialkyles

Country Status (7)

Country Link
EP (1) EP1036088A1 (fr)
JP (1) JP2001525333A (fr)
AR (1) AR017423A1 (fr)
AU (1) AU737219B2 (fr)
BR (1) BR9814717A (fr)
CA (1) CA2299396A1 (fr)
WO (1) WO1999028336A1 (fr)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2078890T3 (es) * 1986-10-09 1996-01-01 Upjohn Co Amino esteroides en c20 a c26.

Also Published As

Publication number Publication date
AU737219B2 (en) 2001-08-09
BR9814717A (pt) 2000-10-03
AU1311599A (en) 1999-06-16
JP2001525333A (ja) 2001-12-11
EP1036088A1 (fr) 2000-09-20
AR017423A1 (es) 2001-09-05
WO1999028336A1 (fr) 1999-06-10

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Legal Events

Date Code Title Description
FZDE Discontinued