CA2288274A1 - Benzothiopyranopyridines regioisomeres a activite antitumorale - Google Patents

Benzothiopyranopyridines regioisomeres a activite antitumorale Download PDF

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Publication number
CA2288274A1
CA2288274A1 CA002288274A CA2288274A CA2288274A1 CA 2288274 A1 CA2288274 A1 CA 2288274A1 CA 002288274 A CA002288274 A CA 002288274A CA 2288274 A CA2288274 A CA 2288274A CA 2288274 A1 CA2288274 A1 CA 2288274A1
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CA
Canada
Prior art keywords
alkyl
group
nr2r3
ppm
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002288274A
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English (en)
Inventor
A. Paul Krapcho
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
University of Vermont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Vermont filed Critical University of Vermont
Publication of CA2288274A1 publication Critical patent/CA2288274A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des benzothiopyrano [2,3-b]-, [3,2-b]- et [3,2-c]-pyridines substituées en positions 6 et 9. Les composés de l'inventions sont représentés par la formule générale (I). En l'occurrence, X, Y ou Z est azote (-N=), les autres étant carbone (-CH=). R' appartient au groupe des (C¿1?-C¿4?)alkyle, nitro ou -NH-R¿1?, R¿1? appartenant au groupe des -CO-CH¿2?-NR¿2?R¿3?, (C¿1?-C¿10?)alkyle, (C¿2?-C¿10?)alkyle où un ou deux substituants appartiennent au groupe des -OR¿4? et -NR¿2?R¿3?, (C¿1?-C¿10?)alkyle interrompu par un ou deux atomes d'oxygène ou par un groupe -NR¿5?-, et où ledit (C¿2?-C¿10?)alkyle est éventuellement substitué par un ou deux groupes hydroxy ou -NR¿2?R¿3?. R appartient au groupe des hydrogène, (C¿1?-C¿10?)alkyle et (C¿2?-C¿10?)alkyle où un ou deux substituant appartiennent au groupe des -OR¿4?, -NR¿2?R¿3? et (C¿2?-C¿10?)alkyle interrompu par un ou deux atomes d'oxygène ou par un groupe -NR¿5?-, et où ledit (C¿2?-C¿10?)alkyle est éventuellement substitué par un ou deux groupes hydroxy ou -NR¿2?R¿3?. Ces composés font preuve d'une activité antitumorale contre la leucémie humaine et les tumeurs solides sensible au traitement par la mitoxantrone et des antibiotiques antitumoraux tels que la doxorubicine.
CA002288274A 1997-04-28 1998-04-28 Benzothiopyranopyridines regioisomeres a activite antitumorale Abandoned CA2288274A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4497097P 1997-04-28 1997-04-28
US60/044,970 1997-04-28
PCT/US1998/008398 WO1998049172A1 (fr) 1997-04-28 1998-04-28 Benzothiopyranopyridines regioisomeres a activite antitumorale

Publications (1)

Publication Number Publication Date
CA2288274A1 true CA2288274A1 (fr) 1998-11-05

Family

ID=21935312

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002288274A Abandoned CA2288274A1 (fr) 1997-04-28 1998-04-28 Benzothiopyranopyridines regioisomeres a activite antitumorale

Country Status (4)

Country Link
EP (1) EP0981528A1 (fr)
AU (1) AU7162898A (fr)
CA (1) CA2288274A1 (fr)
WO (1) WO1998049172A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6747039B2 (en) 2002-03-12 2004-06-08 Albany Molecular Research, Inc. Aza-benzothiopyranoindazoles with antitumor activity
US20030212061A1 (en) * 2002-03-12 2003-11-13 Haydar Simon N. Aza-thioxanthenones with antitumor activity
WO2007032818A2 (fr) * 2005-09-12 2007-03-22 Zoltan Laboratories Llc Composés et compositions permettant de contrôler une croissance cellulaire anormale
GB201214169D0 (en) * 2012-08-08 2012-09-19 Biostatus Ltd New compounds and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55122785A (en) * 1979-03-15 1980-09-20 Yoshitomi Pharmaceut Ind Ltd Preparation of benzopyranopyridine derivative
AU713107B2 (en) * 1995-07-06 1999-11-25 University Of Vermont, The New pyrido-thiopyranoindazoles with antitumor activity

Also Published As

Publication number Publication date
WO1998049172A1 (fr) 1998-11-05
EP0981528A1 (fr) 2000-03-01
AU7162898A (en) 1998-11-24

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Legal Events

Date Code Title Description
FZDE Discontinued