CA2282858A1 - Stealth virus nucleic acids and related methods - Google Patents

Abstract

Stealth viruses comprise a molecularly heterogeneous grouping of atypically structured, vacuolating cytopathic viruses, that cause persistent systemic infection, often with neuropsychiatric and potentially with oncogenic and autoimmune manifestations, in the absence of significant anti-viral inflammation. The appearance, progression and host range characteristics of the cytopathic effect (CPE) distinguish stealth viruses from conventional human cytopathic viruses, including herpesviruses, enteroviruses and adenoviruses. Electron microscopy, serology and molecular-based assays can be used to further differentiate stealth viruses from conventional viruses. Stealth viruses can assimilate various cellular-derived and bacteria-derived genes and potentially transfer such genes between individuals or similar or even differing species. This application describes methods for detecting stealth viruses using molecular probes and for determining the composition of individual stealth virus isolates, based on the DNA and/or RNA nucleotide sequences detectable in cultures and in clinical and other materials containing a stealth virus.

Description

DescriQtion Stealth Virus Nucleic Acids and Related Methods Technical Field The present invention primarily relates to diagnosis of infections that are caused by atypically structured cytopathic viruses. It provides viral isolates and sequence data on representative isolates.
Methods are described for obtaining nucleic acid sequences contained within additional isolates of this molecularly heterogeneous grouping of cytopathic viruses and for using the sequence data for the design and implementation of sensitive virus detection methods, and for determining modes of vinrs transmission, choices of therapy, and likely mechanisms of induced cell damage. Sequence data are also useful in the classification. characterization and quantitation of individual viral isolates, and in determining other potential uses of isolated viruses, such as their use as vectors for the transfer of genetic information.
Background Art This section provides an up-to-date overview of conventional viruses, their modes of detection, using culture, immunological and molecular probe based assays, and the utility of deriving nucleic acid sequence information on viral isolates.
A. Viruses 1. Definition: Viruses are very small organism, which can grow and multiply, only inside of a cell. They require the contents of the cell to manufacture the various components of the virus. These components are; i) DNA or RNA nucleic acids, comprising a chain or polymer of nucleotides connected through a phohodiester bond from the 5' to 3' carbon atoms of the sugar moiety of the nucleotide. These are the genes of the virus. Viral particles contain either RNA or DNA but not both, whereas bacteria and cells have both RNA and DNA. The amount of DNA or RNA in a virus varies depending on the type of virus. Small viruses, e.g. papillomavirus have about 9,000 nucleotide molecules strung in a row. Big viruses, e.g. a herpesvirus can have 200,000 nucleotides. ii) A protein (or proteins) which associate with the DNA or RNA and provides some protection as the virus passes between cells. The proteins make up the capsid of the virus and are formed by the aggregation of normally soluble proteins into a shell-like structure iii) Some viruses also have an outer protective layer of proteins in a lipid envelope, and sometimes also between the capsid and the envelope (termed tegument proteins). Finally, some but not all viruses possess various enzymes involved directly or indirectly in the replication of the viral nucleic acids 2. Classification: Viruses are classified in several ways, for example. i) Whether the viral particles contain RNA or DNA. Some RNA viruses convert to DNA after they enter a cell and are called retroviruses. ii) Whether the genome is single (ss) or double stranded (ds). iii) For single stranded RNA viruses, the sequence may directly code for its protein (positive, +ve, stranded), or consist of the opposite or negative, -ve, strand. iv) The genome may be linear or circular and may be in a single segment, or in multiple segments. iv) The genome size and overall shape of the virus and whether an envelope is present are also major criteria used for classification. v) Finally, the kinds of diseases produced can distinguish different viruses. Related viruses are successively grouped into species, genera, families and orders.

3. Viral Diseases: Viruses which cause disease are termed pathogenic. Examples of virus induced diseases include; influenza, the common cold, chickenpox, measles, mumps, rubella, hepatitis, infectious mononucleosis, polio, etc. Some viruses are thought to play a contributing role in causing certain types of cancers, such as papillomavirus in cervical cancer, and Epstein-Barr virus in Burkitt's lymphoma. Viruses are not widely regarded as a cause of lung cancers, breast cancers, gastrointestinal tumors, brain tumors and melanomas. A retrovirus called human~immunodeficiency virus (HIV) damages the immune system and causes the Acquired Immunodeficiency Syndrome (AIDS).

4. Mechanism of Viral-Induced Diseases. Some viruses can directly damaue cells by triggering a cellular destructive process termed apoptosis; andlor by usurping the cells metabolic resources;
and/or by producing toxic components; all of these processes can interfere with the cells' normal functions. Cell damaging viruses will generally induce a morphological alteration in infected cells which is commonly referred to as a cytopathic efFect (CPE). This change can be seen in infected tissues and under suitable cell culture conditions can be seen in cells grown in vitro in tissue cultures.
Viruses can also cause cells to express viral and/or altered cellular components that may become targets for anti-cellular immunity. HIV directly attacks the immune system leaving the infected host vulnerable to secondary infections by other pathogens. Viruses that have been associated with cancers are thought to act mainly by causing mutations in critical cellular genes.

5. Distinction between Prions and Viruses. Certain types of cellular proteins have the property, similar to viral capsid proteins, that when present in a particular configuration; will complex with corresponding soluble protein resulting in the assembly of insoluble structures formed by induced aggregation of the molecules. Abnormally configured cellular protein can initiate a chain reaction leading to the progressive accumulation of protease-resistant material termed amyloid. Such proteins have been termed "prions" for "proteinaceous infectious particles".
Certain humans and animals inherit genetically altered normal protein with an enhanced tendency to "spontaneously"
generate the small quantity of the abnormally configured protein to begin the process. If other individuals simply become exposed to these proteins, e.g. by ingestion with food, disease can occur through the progressive conversion of the new host' s proteins, along with the potential of further transmission. Prion diseases include scrapie in sheep, bovine spongiform encephalopathy or mad cow disease in cows and both Creutzfeldt-lakob disease and kuru in humans. A role for nucleic acids in prion disease transmission has been discounted by the scientific community largely because the protein itself appears capable of causing disease and, to date, no transmissible viral nucleic acids have been identified in association with these diseases..
B. Laboratory Diagnosis of Viral Infection:
lmmunological, tissue culture and molecular biological methods are used to diagnose viral WO 99/34019 ~ PCT/US98/27744 infections and to ascertain the extent of viral damage and the quality and intensity of the body's immune response against the viral proteins.
The antibody response to a viral infection normally starts with the relatively transient production of IgM followed by a long lasting production of IgG. For this reason, a specific IgM
antibody response to viral components (termed antigens) can generally be taken as a sign of early infection. The serological detection of free viral antigen can precede the earliest serological response and this type of assay can be useful for certain infections, e.g. parvovirus B
19, HIV, hepatitis B virus (HIiV) and human herpesvirus-6 {HHV-6). Antigen assays can also be used to distinguish persisting infection, in spite of IgG response, from a cured infection. Again, this type of approach has been employed with HIV and HHV-6. The quality and intensity of the anti-viral cellular immune responses can be assessed using lymphocyte subset analyses, natural killer cell mediated cytotoxicity, and measurements of cytokine production including IL2, IL4, interferon, etc. The composition of the viral proteins that act as targets for antibody and cellular immunity can be deduced from a knowledge of the nucleic acid sequences that comprise the virus genome.
Tissue culture methods can provide conclusive evidence of active infection by cytopathic viruses, as well as provide the viral isolate for susceptibility studies to anti-viral agents. The appearance of the CPE and the susceptibility of various cell types to the CPE
can be used as distinguishing criteria in the identification of different types of viruses.
As noted above, several types of viruses induce cellular damage through the induction of apoptosis. This is seen morphologically as cellular shrinkage and progressive~degeneration. Some viruses tend to cause cellular enlargement, rather than shrinkage. A cause of cellular swelling can be disruption of mitochondria) catabolism of lipids, yielding foamy vacuolated cells. Infected cells can fuse with each other yielding cell syncytia.
In general, once a CPE has begun it will progress throughout the culture. With many viruses, however, only certain cell types will display the CPE. For example, human cytomegalovirus (HCMV) will grow in human but not in animal fibroblasts, and not very well in human epithelial cells. The major limitation of tissue culture techniques has been the apparent failure of routine viral cultures to detect the types of viruses to be described in more detail in this application.
Molecular probes: Virus infection can also be inferred from the results of molecular probe based assays. The complimentarity between the nucleotide sequences of a molecular probe and a target nucleic acid results in binding of the probe to the target. Moreover, either through the addition of nucleic acid synthesizing enzymes (polymerises) or simple reliance on the viruses own replicating enzymes, a complex of probe with a target sequence can elicit a synthetic reaction such that the probe is extended from its 3' end with a sequence that is fully complimentary to the part of the target sequence adjacent to the site of initial binding by the probe. This feature has formed the basis of a recycling DNA synthetic technique termed the polymerise chain reaction (PCR).
PCR refers to enzymatic amplification of a defined DNA sequence. It requires the following reactants: target DNA
containing a known sequence to be amplified; oligonucleotide primers complimentary to the flanking regions, on opposing DNA strands, of the particular segment of double stranded DNA to be replicated; DNA polymerise enzyme; deoxynucleotide triphosphates (dNTP) and buffer. The PCR
is performed in a thermal cycling machine. PCR proceeds by denaturing the double stranded DNA
molecule by heat; and cooling in the presence of the oligonucleotide primers.
Because of their high *rB

concentration and greater mobility in solution, the primers bind more rapidly to the target DNA than the slower reannealing process exhibited by the larger complimentary DNA
strands. The primer DNA
complex provides a substrate for DNA polymerise. In the presence of dNTP, the polymerise will extend the primers in a DNA synthesis reaction. Each newly synthesized strand will be complimentary to the template DNA and will acquire at its 3' end, the sequence complimentary to the other primer used in the PCR. On repeating, the newly formed hybrids will denature, thereby providing two additional template molecules during the next primer annealing step. With each successive cycle of heating, primer annealing and primer extension, there will be an exponential increase in the targeted segment of DNA. Eventually, the reaction will become rate limiting due mainly to competition between primer binding and reannealing of the greatly amplified single DNA
molecules synthesized during the PCR. in a typical reaction, however, amplification in the order of 105 fold can be achieved in from 25-30 cycles. The specifically amplified PCR product will be of uniform size corresponding to the distance separating the 5' ends of the two primer binding sites on the opposing strands of the target segment of DNA. 1t can be identified by electrophoresis in agarose gels and further characterized by a hybridization reaction using a labeled probe reactive with the amplified sequence.
For RNA viruses, an initial reverse transcriptase reaction can be performed to convert the RNA to a DNA sequence. The single stranded DNA is replicated to a double stranded molecule which is then amplified by PCR.
Either PCR derived products or synthetic oligonucleotides can be used directly to determine the presence of a viral sequence in clinical material. Various approaches have been used to detect the binding {hybridization) of the probe to its corresponding viral sequence. The major limitation of molecular approaches, including PCR and direct probe based assays, to virus diagnosis, is the requirement to know at least some of the actual sequence of the virus.
This issue can, however, be addressed by using conditions that favor the binding of probes that only partially match their target. PCR products generated in such low stringency reactions will reflect actual sequences of the bound target. By sequencing the PCR products, information can be obtained that will allow for the design of highly specific primer sets.
C. Utility of Nucleic Acid Sequence Information Obtained on Viruses Sequence information on a virus can provide a wealth of useful information way beyond the design of specific PCR primers for diagnostic purposes. The sequences can predict the actual proteins that are encoded by the virus. Such proteins can be synthesized for use as antigens to assess anti-viral immune responses, and to evoke protective immune responses through immunizations.
Antibodies that are formed through infection or by experimental immunization, can also be used to detect the specific virus. Protein data can help determine how a particular virus is able to mediate CPE in tissues and in tissue cultures. Relatively little efforts are directed towards sequencing of individual viral isolates from patients, because of the general assumption that all viruses within a particular category are essentially identical. As will be disclosed below, novel sequence information, especially on previously unrecognized viruses, can provide important new insights into basic molecular mechanisms of viral pathogenesis. In particular, it can help explain how some disease causing viruses have successfully evaded confrontation with the cellular immune system.

D. Viruses as a Potential Cause of Common Non-Inflammatory Diseases In spite of advances in understanding the molecular nature of viruses, and widespread availability of sophisticated viral diagnostic techniques, little regard has been given by others to the possible role of viruses in non-inflammatory illnesses affecting humans and animals. An appreciation, by the inventor, of the existence of previously unrecognized "stealth virus"
infections has opened many opportunities to pursue important avenues of clinical and basic research.
Although, the information provided in this disclosure is primarily directed towards methods of obtaining and utilizing nucleic acid sequence data from various stealth viral isolates, it is likely that the basic concepts will drastically change the approach that clinicians will take to human diseases. Areas of special concern include viral induced brain damage presenting as psychiatric symptoms in adults, learning and behavioral disorders in children and dementia in the elderly. As will be described, the issue of viruses as a cause of common cancers will need to be reopened. The significance of the work also extends to potential contamination of blood and other biological products, transmission of diseases between humans and between humans and animals, possible contamination of foods and other environmental sources. It disclosing the invention it is appropriate to begin with a general overview of stealth viruses. review the established culture methods for these viruses and then address the main topic of this application, which is obtaining and using nucleic acid sequence information on these viruses.
Disclosure of Invention Stealth Adaptation of Viruses as a Means to Evade the Immune System. A major function of the cellular immune system is to recognize and respond to virus infections. A successful immune response can eradicate foreign viruses by destroying infected cells prior to the release of progeny viruses. Symptoms of an acute cytopathic virus infection commonly occur during the time period required to generate a primary cellular immune response, and can also be a byproduct of cellular immune damage inflicted on viral infected cells. Unusually severe infections can occur if the immune system is impaired, for example, as a result of immaturity, chemotherapy, coincident infection with human immunodeficiency virus (HIV), or specific genetic deficits in immune competence. Certain viruses may also interfere with immunological defenses through such mechanisms as downregulation of the expression of histocompatibility antigens, induction of immunosuppressive cv_ tokines and related virokines, and by remaining inactive, as in latent infections.
Stealth adaptation was originally proposed by the inventor as a distinct process whereby a virus could remain actively cvtopathic in the absence of an accompanying inflammatory cellular immune response. Based on histological findings on brain biopsies, and on repeated isolations of atypically structured cytopathic viruses, it was suggested that these viruses lacked critical genes encoding effective targets for the cellular immune system. This original hypothesis is still foreign to most virologists who intuitively believe, either that all viruses possess ample targets for immune recognition and/or that viruses without such critical elements would be unable to replicate, cause cell damage or pass between individuals.
Stealth viruses were defined as cytopathic viruses able to establish a persistent infection because of deletion and/or mutation of specific genes, which, if present, would code for immunogenic components able to evoke an effective anti-viral cellular immune response. The existence of stealth viruses is best understood within the framework of varying strategies used by viruses to evade immune elimination. Essentially, the basic postulates to explain stealth viruses are: i) That relatively few viral components serve as major immunologic targets (epitopes) for T cell recognition of infected cells; and ii) deletion and/or mutation of the genes coding these immunogenic epitopes can yield pathogenic viral variants (stealth viruses) that strategically avoid confrontation with the body's cellular immune defenses.
The definition of stealth viruses does not follow the usual approach of defining specific molecular and morphological characteristics. Thus, as described in the "Background Art" section, the usual classification of viruses begins with the distinction between DNA
and RNA genome. Other characteristics include single stranded or double stranded nucleic acid, polarity of single stranded RNA viruses, mode of viral replication, size and shape of the virion, and whether the virus is enveloped. The approach taken to initially define stealth viruses was based on the appearance of a fairly characteristic vacuolating, foamy cell appearing CPE in culture along with the exclusion of other known viruses. As the work progressed, several individual stealth viral isolates were defined in terms of more conventional criteria, including their electron micrographic appearance, electrophoretic pattern of isolated viral DNA, partial sequencing and probable origin. Even with the best characterized of these stealth virus isolates, however, the strict chemical and morphological classification schemes fail to account for the microheterogeneity and sub-genomic expression that is observed. Moreover, the precise chemical features of one isolate do not adequately encompass the broader concept of a diverse group of cytopathic viruses in which deletion and/or mutation of normally immunogenic components has occurred. Stealth adaptation is viewed as a mechanism to facilitate persistent infection by structurallv_ losing the capacity to evoke an effective anti-viral cellular inflammatory response.
Given the above considerations, stealth viruses do not originate from a single source. It is likely that stealth adaptation can occur with all of the presently known human herpesviruses and many of the additional cytopathic viruses known to affect humans and animals. Viral sources other than herpesviruses are certainly not excluded. In fact, as viruses downsize and simplify, their initial distinguishing characteristics tend to become less important compared to their common pathogenic capacity of overtaxing the metabolic resources of a cell. The application of DNA/RNA isolation and cloning techniques, as provided for in this disclosure, should continue to provide informative sequence data on various stealth viral isolates to help define their individual origins.
Tissue Culture Based Screening Methods for the Detection of Stealth Viruses.
Stealth viruses can most easily be screened for using basic tissue culture techniques.
The viruses are identified by their capacity to induce a CPE in tissue cultures. It is 'advantageous to use a frozen-thawed extract of peripheral blood mononuclear cells added to normal human fibroblasts. The cells are monitored for CPE, and in particular, the formation of enlarged, rounded, vacuolated cells, that often form syncytia. An important observation is that the intensity of the CPE is enhanced by regularly replacing the medium in the tissue cultures, as a means to limit the accumulation of viral inhibiting components.
The CPE can also be enhanced by the addition of 30% boiled supernatants of HCMV infected cultures, and/or by the inclusion of boiled or otherwise inactivated preparations of various viral vaccines, such as a commercial feline rhinotracheitis-calici-panieukopenia-chlamydia psittaci vaccine manufactured by BioCor inc. Omaha, Nebraska. As discussed below, it appears that extraneous viral and bacterial and cellular DNA can become incorporated into the viral replicative process and enhance stealth virus yields. Such additions, are contraindicated when the goal is to obtain primary sequence data on the clinical isolates. Stealth viruses can also be isolated from tissue biopsies, cerebrospinal fluid, semen, urine, throat swabs and feces.
The routine successful culturing of stealth viruses has provided valuable insights into the wide range of illnesses that can fit the pattern of a persisting viral infection.
White, the initial focus was on patients with neuropsychiatric illnesses, including the chronic fatigue syndrome (CFS), it became apparent that very severe, and even fatal neurological illnesses, were occurring in virus infected patients. The unique susceptibility of the brain to stealth virus infections, could be explained on the basis of spatial segregation of the various functions of the brain. Thus unlike other organs, limited damage to the brain can not be compensated for by heightened activity elsewhere. The induction of malignancy provides another example where damage to even a single cell can have dire consequences.
Evidence for stealth viruses has been obtained in a number of patients with myelomas, melanomas, brain tumors, lymphomas and breast cancers (see below). Stealth viruses have also been cultured from animals, including symptomatic pets of patients with neuropsychiatric and oncogenic illnesses.
The finding of atypical cytopathic viruses in patients with such a diverse array of clinical findings has unfortunately tended to impede rather than accelerate scientific acceptance of the basic culture findings. This is one reason for again emphasizing the potential value of actual sequence data on cultured virus isolates. The combination of tissue culture and molecular methods has provided informative sequence data on several stealth virus isolates. Moreover, recombinant clones resulting from these studies have provided a useful set of reagents to pursue stealth viral studies as well as other research and commercial endeavors.
Obtaining Sequence Information on Stealth Viruses. Methods are in place such that once a stealth virus is cultured, one can readily proceed to defining its composition. As described in the "Modes for Carrying Out the Invention" this can be achieved using a variety of molecular methods, including PCR, primer induced nucleic acid synthesis, isolation of viral DNA
and/or RNA. The nucleic acids can be sequenced and this information used to ascertain the potential biological properties of the viral isolate. Other approaches are also available including amino acid sequencing of protein products in culture supernatants and deriving, by reverse genetics, the probable nucleotide sequence of the coding gene. Cellular toxic products can also be isolated from cultures and their composition can be determined and related back to the genetic composition of the virus. Of these various approaches, the "Best Mode for Carrying Out the Invention" proceeds from culturing a stealth virus and determining its genetic sequence as described in the following section.

Modes for Carrying Out the Invention The culturing of the stealth viruses comprises inoculating a test tube containing human MRC-S fibroblasts with a frozen-thawed aliquot of ficoll-paque isolated and washed mononuclear cells obtained from the equivalent of 4 mls of blood collected in an ACD (acid citrate dextrose) anti-coagulated blood sample. The MRC-5 cells are maintained in 5 mls of X-Vivo I S
serum free medium (BioWhittaker, Walkersville Maryland, USA). The tubes are placed on a rotator at 12 revolutions per minute in a 37°C incubator. The cultures are observed daily for a CPE.
A positive culture is defined as i) the loss of the following normal features of the cell monolayer. Normal characteristics include a monolayer consisting of an inconspicious sheet of elongated flat cells without noticeable intercellular gaps. The normal monolayer extends to the base of the test tube without evidence of cellular detachment. Similarly, the periphery of the normal monolayer should have < 5% of cells showing signs of rounding and/or enlargement. The monolayer should also not display areas of pigmentation or granularity. In addition to the loss of such normal features, a typical positive culture will show most of the following changes. The monolayer transforms to a rather coarse interwoven meshwork of readily apparent cells with intracellular retraction; evidence of detachment of cells, especially from the base and periphery, with scattered islands of reattached cells. Parts of the monolayer and the reattaching cells become foci of enlarged, rounded, or distinctly abnormal appearing cells, either alone or in apparent syncytia. Multiple areas of increased pigmentation and/or patches of residual cellular debris can be seen. An important feature of any questionable culture is the marked deterioration in the overall appearance of the culture and in individual cells I 5-120 minutes following replacement of the old media with fresh media. Signs of cellular destruction, abundant lipid accumulations, extraneous particulate matter, and formation of granular, rod shaped and branching structures can be observed over several days. Typically, the positive cultures do not undergo the cell shrinkage and disappearance seen in control cultures. Moreover, the CPE can be transferred from a positive culture by using a frozen-thawed extract of centrifuged cells, detached by gentle vortexing a positive culture. Secondary and tertiary cultures will typically show a more subdued and focal changes. Frequent, even daily refeeding, especially with media enhanced with boiled supernatants of human cytomegaloviral or other herpesviruses and even positive stealth viruses, is sometimes a critical element in maintaining strongly positive cultures. Typically a 30% addition of boiled supernatant of a human cytomegalovirus culture, is used for this purpose. Additional confirmatory tests can include positive immunofluorescence of infected cells using selected human sera, wide range of permissive cell types, and exclusion of intact conventional viruses using specific antisera and molecular based assays. One aspect of the molecular based confirmatory assays is the generation of atypically sized PCR products using various primer sets based on sequences of known conventional viruses or on known sequences of previously cultured stealth viruses. Sequence information obtained on such atypically sized PCR products, including products generated from reverse transcribed RNA, can allow for the design of additional PCR primers tailored for the specific stealth virus being cultured. The following information provides an outline of the approach taken. and describes the results obtained in the molecular analysis of a "Stealth Adapted African Green Monkey Simian Cytomegalovirus"
Stealth Virus. The virus was originally isolated using culture methods from a patient with chronic fatigue syndrome. An aliquot was deposited at the American tye Culture Collection ATCC and given accession number VR2343. A culture was reestablished from a frozen aliquot of an early passage and grown on human fibroblasts, (BioWhittaker, Inc.. Walkersville. 1~1D.).

PCR Products: The cultures were used to generate PCR products. Several primer sets were initially used. A set of primers, designated SK43 and SK44, based on the tax genes of HTLV I and HTLV
II, respectively, yielded 2 products of approximately 1,500 bases and a smaller product of 0.67 kb bases.
DNA Extraction and Cloning. PCR products were isolated from agarose gels and ligated into a commercially available plasmid ( pBluescript, available from Stratagene, La Jolla, CA). Purified DNA
was also extracted from the cultures, cut with a restriction enzyme, and cloned into pBluescript. Two independent experiments were performed on culture-derived DNA, yielding two sets of cloned DNA.
An interesting observation was made during the work up phase for these studies. Restriction enzyme digestion of a conventionally structured virus is expected to yield equimolar amounts of contiguous fragments representing the entire genome. On agarose gel electrophoresis, the digestion products should be seen as multiple bands of essentially equal intensity. In contrast to these expected findings, electrophoresis of restriction enzyme digested DNA isolated from the stealth virus cultures yielded numerous bands of widely differing intensities. The uncut DNA migrated as a band of approximately 20 kilobases (kb), yet the aggregate size of the bands following digestion clearly exceeded 50 kb. The PCR generated products and the products of enryme digestion were ligated into pBluescript plasmids and cloned.
Clones and Sequencing. The PCR clones were designated IS-5-2, 15-5-4 and SK43/43. The 3B series of clones was obtained using EcoRI digestion of DNA extracted from the material, pelleted by ultracentrifugation, that was present in filtered supernatants of infected MRC-5 cells. The C16 series of clones was obtained using SacI digestion of agarose banded DNA extracted from the material, pelleted by ultracentrifugation, present in filtered supernatant of lysed virus-infected cells. The T3 and T7 promoter sites of the pBluescript vector were used in sequencing reactions to obtain partial sequence data from the ends of each of the inserts. Extended sequences of the inserts in selected clones were obtained using primers based on the T3 and T7 readouts. The sequencing services of the BioServe Biotechnology, Laurel, MD, U.S. Biochemical, Cleveland, OH, City of Hope Cancer Center, Durate CA; Midland Certified Reagent Company, Midland, TX; and Lark Technology, Houston, TX, were used with excellent correlation of the occasional duplicate and even triplicate testing of the same clones. The individual sequences were analyzed against GenBank entries using the gapped BIastN and unfiltered BlastX programs of the National Center for Biotechnology Information (NCBI) of the National (.ibrary of Medicine. A "p" value of < a -2.0 was used as a cutoff for a significant nucleotide or amino acid sequence homology.
Results. The PCR product I 5-5-4 was t .5 kb bases in length and flanked by the SK44 primer.
Sequencing of this product showed a statistical significant relatedness, by both BIastN analysis, to a portion ofthe human cytomegalovirus (HCMV) genome that codes a protein designated UL34. The 15-5-2 product of a similar size and was also flanked by the SK44 primer. Its internal sequence could not, however, be matched to any known sequence. The 0.67 kb product was flanked by the SK43 primer and when first examined had no significant matching with any GenBank entry.
At least partial sequencing has also been obtained on over 300 clones from the virus infected cultures.

For many of the clones, the sequencing merely comprise a relatively short readout from the T3 and T7 promoter sites of the pBluescript plasmid. For selected clones, complete (C) sequencing has been obtained. As with the 15-5-4 PCR product, several of the clones contained sequences that could be statistically aligned by BlastN analysis to at least some portion of the protein coding regions of the HCMV genome. The BIastX program, which is based on the deduced amino acid sequences coded by a nucleotide sequence, identified many additional clones with significant partial sequence homology to various HCMV proteins. The matching was often incomplete with apparent gaps and occasional insertions in the sequences of the stealth virus clones. An overall indication of the HCMV
proteins for which at least some portions could be aligned with a sequence contained in one or more of the stealth virus clones is shown in Table 1.
Table 1. HCMV Proteins Identified by Homology Searching Using Sequences in the DNA
Extracted From Cultures of Stealth Virus-I

* Greater than 5 clones matched to the proteins that are underlined and ten or more clones matched to the proteins highlighted by bold print.
Note: The genome of the fully sequenced, laboratory-adapted, AD169 strain of HCMV comprises 235,000 nucleotides base pairs. The virus has two linear segments, designated unique Ions (UL) and unique short (US). Each segment is flanked by relatively small regions of repetitive sequences. The potential proteins coded by the UL and US regions are designated numerically, and extend from UL1-132 and US I-36. Additional potential open reading frames are present within the repeat regions that flank both the UL and US segments. Fresh clinical isolates of HCMV
contain some additional protein coding sequences, designated UL 133-151, that are not present in the laboratory adapted AD 169 strain. Sequence comparisons of animal and human herpesviruses indicate a greater conservatism of the central core sequences from UL30 to UL 125, compared to the sequences prior to UL30 and beyond UL 135.
As shown in the above Table, the nucleotide and protein matching regions of the stealth virus are widely distributed throughout much of the central core region of the HCMV genome and in the later part of the US region. The matching sequences were not uniformly distributed through the central core region of the HCMV genome. For example of 300 clones, 10 or more clones matched to the UL36, UL52, UL86 and US28 regions of the HCMV genome, while other regions were not represented by any of the clones from which sequence data have so far been obtained.. The homologue of the UL83 gene of HCMV was not represented in any of the sequenced stealth virus clones. The UL83 lower matrix protein (pp65) which is the major target for cytotoxic T cell mediated immunity against HCMV (Wills MR, Canmichel AJ, Mynard K., et al. "The human cytotoxic T-lymphocyte response to cytomegalovirus is dominated by structural protein pp65: frequency, specificity, and T-cell receptor usage of pp65-specific CTL. J. Viroi. 70:
7569-79, 1996). This finding is consistent with the underlying assumption concerning gene deletion as a means for stealth adapted viruses to bypass cellular immune defense mechanisms. Major deletions were also seen in portions of many of the proteins that were identified using the BlasiX program.
Moreover, many of the deduced amino acid sequences were not included in analyses based on putative open reading frames (data not shown). .
To recapitulate the findings, the number of clones that matched to specific regions of the HCMV genome varied from a single clone to multiple clones. The regions of the HCMV genome for which > 5 clones contained statistically significant matching sequences by BlastX analysis are underlined in the Table. Regions of the HCMV genome in the vicinity of the UL36, UL52, UL86 and US28 gene product were each represented by 10 or more of the 300 analyzed clones. Noticeably absent were sequences of the major target for anti-HCMV cellular immunity UL83, whereas 6 clones were identified that matched to portions of the neighboring UL84. All of these clones extended forward towards the UL86 and UL87 gene products. In addition to apparent absence of major proteins, many of the proteins for which partial matching was seen, showed major deletions when compared with the corresponding protein in HCMV. Moreover, individual clones that matched to similar regions of the HCMV genome, often displayed minor sequence differences, indicative of an unstable viral genome. These differences occasionally disrupted the potential of a contiguous nucleotide sequences to provide a functional open reading frame. They also could account for the unequal distribution and surprisingly large number of products seen following restriction enzyme digestion of the DNA derived from the stealth virus cultures. Also of note, the aggregate lengths of the cloned stealth viral DNA sequences that match to non-overlapping regions of the HCMV genome exceeded 100 kb. Since, as mentioned above, the stealth virus DNA migrates in agarose gels with a size of only approximately 20 kb, it can be assumed that the genome consists of multiple fragments, rather than as an entire full length cytomegalovirai genome.
Limited nucleotide and amino acid sequence data are available for rhesus cytomegalovinrs (RhCMV). Several of these sequences con esponded to regions of the HCMV genome which matched to portions of the prototype stealth virus sequence. For these regions, it was possible to compare the relative relatedness of the stealth virus sequence with that of RhCMV and HCMV. This analysis showed a significantly higher homology of the stealth vines sequences to RhCMV
compared to HCMV. A comparison of the p values seen when matching the nucleotide sequences using BIastN
program and deduced amino acid sequences using BIastX program of the stealth virus clones against homologous regions of HCMV and RhCMV sequences are listed in Table 2.

Table 2. Comparison of Relative Homology of Sequences Present in Various Clones Derived From a Stealth Virus Culture to Corresponding Sequences in Human and Rhesus Cytomegaloviruses Analyzed Using BlastN and BIastX Programs Clone Region of BlastN Analysis BIastX Analysis Homology HCMV RhCMV HCMV RhCMV
C16289.T3UL31 NS 9e-21 2e-41 8e-53 C16292.T7UL45 NS Se-04 2e-26 le-33 3B51.T7 UL47 NS 6e-13 Se-25 6e-38 3B642.C UL48 NS NS NS 9e-26 C16169.T7UL54 Se-07 4e-44 2e-42 2e-50 3B529.C UL71 Se-12 8e-23 Se-09 le-14 3B559.T3 UL76 NS 3e-15 4e-11 3e-26 3B13.T7 UL87 NS e-104 2e-83 e-102 C16123.T7UL89 Se-51 e-113 7e-84 2e-89 C16145.T7UL105 NS le-OS le-13 3e-i6 3B546.C UL123 7e-09 le-71 8e-28 3e-61 C162113.T3US21 NS NS 2e-61 8e-27 3B656.T7 US22 NS 7e-09 8e-28 3e-6l The higher homology to RhCMV compared to HCMV identified the stealth virus as not of HCMV origin. The variable statistical levels of the matching clearly distinguishes the stealth virus from RhCMV. Complete identity over a stretch of hundred or more bases will typically yield p values of < e- I 00.
Very limited genetic information is currently available for other primate cytomegafoviruses.
There are, however, several sequences in GenBank for African green monkey simian cytomegalovirus (SCMV). This provided an opportunity to directly compare a stealth virus sequence with several cytomegaloviruses. A much greater homology was seen with SCMV than for any other cytomegalovirus. Sequence data supporting the unequivocal origin of the stealth virus from is provided by comparing the sequence of the immediate-early gene transcriptional unit of SCMV with that of stealth virus clone 3B546 (Table 3). Several small gaps had to be placed in the stealth virus sequence for a proper alignment. The extraordinary high degree of homology between the stealth virus and regions of the SCMV genome, with p values often reaching zero, unequivocally identified the virus as a derivative of SCMV.

Table 3. Comparison of Sequence of Clone 3B546 Derived from a Stealth Virus With the Sequence of the Immediate Early IE 94 Transcriptional Unit of SCMV
Stealth Virus Sequence SCMV Sequence Nucleotide Identity p Value 1 - 421 8410 - 7984 408/428 0.0 408 - 930 7986 - 7464 504/525 0.0 929 - 4193 7435 - 4168 3085/3272 0.0 4 i 85 - 4360 3985 - 3880 259/297 3e-95 4496 - 4853 3707 - 3347 510/536 0.0 5046 - 5333 . 2941 - 2654 263/288 e-I 11 5394 - 6026 2557 - 1925 594/633 0.0 6043 7926 1893 - 11 1782/ 1884 0.0 The overall alignment of the two sequences required that variable sized gaps be present between the above listed matching segments. The size of the gaps for SCMV were larger than those for the stealth virus, consistent with other indications of genetic deletions.
Most of the additional sequences deleted from the stealth virus were in non-coding areas, including introns, known to exist within the SCMV lE gene. Highly significant matching to two other regions of the SCMV genome was also present.
The identification of an SCMV-derived stealth virus was not an isolated finding. Indeed, a young woman with a prior history of bi-polar psychiatric illness was admitted to hospital because of coma and seizures. Although her cerebrospinal fluid was essentially non-inflammatory, it grew out an atypical virus showing extensive molecular cross-reactivity in PCR and direct probe-based assays as did the viral isolate from the CFS patient. Yet by culture, the wide host range of permissive cells, and the formation of vacuolated foamy syncytia, clearly distinguished the stealth viruses from the standard Colburn laboratory strain of SCMV. Such differences should be reflected in the nucleotide sequences of the viruses. Consistent with this conclusion was the fact that while SCMV had clearly contributed multiple genetic sequences to the stealth virus, other regions of the virus could not be aligned to known herpesvirai sequences. The virus DNA appeared to comprise multiple fragments with stretches of herpesviral-derived DNA, adjacent to sequences of uncertain origin. The virus also exhibited considerable sequence micro-heterogeneity. Similar stretches of the viral genome often showed multiple deletions. additions, substitutions and duplications. Sequence heterogeneity was confirmed in stretches of the genome in which genetic recombination had clearly occurred.

WO 99/34019 ~ ø PCT/US98/2??44 The possibility of cellular sequences contributing to portions of the prototype stealth virus genome was suggested by the significant partial homology (p < 0.05) of a portion of one of the viral DNA-derived clones to a cellular gene. With the ever increasing database of cellular sequences and the recent introduction of a "gapped" BlastN program, redoing the original analysis has provided many additional examples of cellular-derived sequences within the cloned DNA
from the stealth virus culture. For example, the SK43/43 derived PCR product matches closely to a cellular gene in the Xp22 166-169 region of the human genome (GenBank accession AC005145) with a p value of 0Ø
Other examples of clones from the SCMV-derived stealth virus culture containing cellular related sequences are provided in Table 4.
Tale 4 Regions of Homolog~r of Stealth Virus Associated Sequences with Cellular Genes Stealth Region of Cellular genes) Number of p value virus clone with clone numbermatching to maximum homology matching cell sequence (GenBank accessionnucleotides (No. ofbases)(*reiterated sequence) C1629.T3 124-345 AA570230* 98/111 1 e-20 (512) C I 629.T7 25-76 Z97200* 50/52 I e- I 5 (410) C16261.T3 51 l-534 N529i4 26/27 5 e-04 (676) C16261.T7 97-119 AC002480 21/21 4 e-03 (536) C 16242.T3 388-413 AL008718* 29/29 3 e-08 (620) C 16242.T7 None detected (563) C16145.T3 335-361 AA535872 27/27 I e-OS
(U27784) (561 ) C16145 T7 None detected**
(U27938) (528) *rB

WO 99/34019 ~ 5 PCT/US98/27744 * Reiterated sequence were present in multiple copies within the cellular gene. Most of the matching sequences were also repetitive with the BlastN program identifying somewhat similar sequences in multiple cellular genes.
** Partial homology to human CMV is present. Specifically, 81 of the first 95 bases match to human cytomegalovirus (GenBank accession number X17403) at position 153,273 to 153,367 (p=1 e-12) The presence of rearranged, mutated, cellular sequences in stealth viral cultures is corroborated by the sequences present in various PCR products generated using the same set of SK43/SK44 primers in stealth virus cultures from three additional patients.
Multiple distinct products were generated from each of the patients. Sequencing of the products showed variable patterns of incorporation of the different primers. Several of the products were identifiable on the basis of Blast analysis as being of cellular origin Table 5 .
Table S Matching to Cellular Sequences of Cloned PCR Products Amplified From Stealth Viral Cultures of Additional Patients Usins~ the SK43/SK44 Primers Patient SK primers) Number of BLASTN homology to cellular gene Clone No. incorporated* bases GenBank accession, Nucleotide match, p value sequenced Patient LB
LB.43 43/44 507 AA429618 175/189 1 e-66 AA429619 104/115 4 e-32 AA429619 89/90 4 e-22 Patient KE
C1113.T3 43 211 AA429618 162/176 S e-57 C1113.T7 44 280 AA429619 37/38 2 e-10 C 1123.T3 44 207 None identified C1123.T7 43 216 AF027598 63/b9 1 e-16 C 1 ! 32.T3 43 21 ? None identified C 1132.T7 44 272 None identified C1142.T3 43 246 AC002377 48/53 2 e-09 C 1142.T7 44 275 AC003 I OS 31 /31 3 e-08 C 1 ! S 1.T3 43 228 282216 122/ 133 7 e-43 C 11 S I .T7 44 236 282250 127/ 144 5 e-25 C 1 I 63.T3 43 131 None identified C1163.T7 44 2l6 None identified Patient TR
C 1311.T3 43 299 None identified C1311.T7 44 227 None identified C 13 I 43 205 AF027598 63/69 1 e-17 3.T3 C1313.T7 44 171 None identified C 1322.T3 44 165 None identified C I 322.T743 89 AA429618 26/26 5 e-06 C1325.T3 44 182 073168 100/105 3 e-38 C 1325.T7 43 158 None identified C1333.T3 44 169 247066 82/94 3 e-16 C1333.T7 43 161 None identified C 1334.T3 44 185 None identified C1334.T7 43 164 None identified C1335.T3 43 138 M32672 33/36 2 e-04 C1335.T7 44 236 AC003015 31/31 2 e-08 *Slight differences were occasionally noted in the primer sequences. Selection for minor variations in primer sequence has been previously noted in performing PCR assays with these primers.
Additional primer sets that have been used to generate PCR products in various stealth virus cultures. Some of the more successful primers have been based on internal sequences of various clones obtained from the stealth virus culture. An initial indication of a potentially successful primer is based is heightened synthesis of RNA and/or DNA when the primer is added directly to an extract of a stealth virus culture. Synthesis is presumably being induced by a viral or activated cellular polymerise. Additional synthesis can be induced by the addition of DNA and RNA
dependent polymerises. The importance of RNA dependent DNA polymerise was highlighted in a series of PCR
assays performed on a stealth virus culture from a nurse with CFS. No products were seen using the regular PCR format, yet multiple distinct products were seen if an initial reverse transcriptase reaction was performed. This finding indicated that the template to which the primer was binding was RNA.
The actual sequences used in this study were based on several clones that contained commonly WO 99/34019 ~ ~ PCT/US98/27744 occurring regions of homology to HCMV, and subsequently shown to be even more akin to sequences of RhCMV. The sequences are shown in Table 6.
Table 5. Primers Based on Sequences of Cloned Regions of Stealth Virus-1 Used to Amplify Products by Reverse Transcription Followed by PCR From Positive Stealth Virus Culture From the Cerebrospinal Fluid of a Nurse With a Chronic Fatigue Syndrome Like Neurological Illness GenBank Plasmid Size of PCR product Primer sequence accession No. designation with stealth virus-1 027952 C 162114 279 by 5'-AACCATGTCTGCCACATCG-3' 5'-CAATAGGATCTCTCGCGCAC-3' 027916 38647 373 by 5'-CGCTGTCGCTCTCTTCCTT-3' 5'-GAGCACGATACGGTGTTGC-3' 027888 38412 374 by 5'-CCTGTTGTCATCTTGTTCAGG-3' 5'-AATGTTCGACAGTCTGCGC-3' PCR assays were initially performed on DNA extracted From the patient's cultures with DNA
from an SCMV culture serving as a positive control. Each of the primer sets tested gave negative results when tested on DNA extracted from the patient's positive culture. When the same primers were used in reverse transcriptase PCR (RT-PCR) assay on RNA extracted from patient's culture, clearly defined PCR products were generated. The PCR product generated with the primer set based on plasmid C1621 14 was similar in size to the 278 base pair (bp) product expected for stealth virus-1.
This primer set yielded a similarly sized, but faint product with SCMV. The primer sct based on piasmid 8614 wives a similar size product with SCMV and stealth virus-1 of 279 bp. A distinctly larger product than seen with SCMV was generated using the patient's culture (480 by compared to 373 bp). Multiple additional faint bands were also eenerated. The primer set based on plasmid 3B412, generated two products (550 by and a less intense band of 425 bp). Both of these products were considerably larLer than the product seen with SCMV or predicted for stealth virus-1 ( 374 bp).

Renewed interest in pursuing cellular as well as viral sequences in stealth viruses was prompted by the realization that certain stealth viruses could potentially assimilate and transmit genes able to transform cells. A search was, therefore, made for any cellular sequences related to known oncogenes. Preliminary indications for this were found with sequences obtained from certain stealth virus cultures and confirmed by additional sequencing of the SCMV-derived prototype stealth virus.
Specifically the sequence data show that parts of the virus has acquired several copies of a gene with a deduced amino acid sequence closely related to that of the oncogene termed melanoma growth stimulatory activity (MGSA/GRO-alpha) chemokine . Please note that this specific example was not included in the application for which priority is requested. The concept and prediction of this finding was, however, expressed. The 3B516 clone was fully sequenced during 1998.
The ends of Eve partially sequenced clones matched by BlastX analysis to the MGSA/GRO-alpha and to other closely related chemokine proteins. One of the clones, 3B516, was completely sequenced. It comprised 5,820 nucleotides. Except for matches to the other four clones from the stealth virus cultures (3B33, 3B624, 3B654 and 3B675), BlastN did not reveal significant homologies with current GenBank entries. By BlastX analysis, however, the nucleotide sequence from the left side of the clone could be translated into a string of proteins with highly significant homologies to the ULl4l, UL144, and UL145 proteins respectively of the Toledo strain of HCMV. An apparent open reading frame (ORF) was situated slightly beyond the region coding for the UL145 protein. The deduced amino acid sequence of this ORF failed to show a statistically significant match to any protein entries on GenBank. It did, however, show a weak partial matching to a human cadherin tumor suppressor protein. The right side of the clone contained three discrete regions, each of which could be translated into proteins that matched to MGSA/GRO-alpha chemokine.
Two of the matches were statistically highly significant. Another potential open reading frame was situated between the region of clone 3B516 that showed a weak homology to the cadherin tumor suppressor protein and the region showing an identified, but statistically insignificant, homology to the MGSA/GRO-alpha chemokine. BIastX analysis matched this region to a human alpha chemokine that is only distantly related to the MGSA/GRO-alpha chemokine. The BlastX results indicating the best matching proteins for the various regions of clone 3B516, are summarized in Table 7. The Table also shows the percent identity and calculated "p" value for the HCMV matching sequences.

WO 99/34019 ~ 9 PCT/US98/27744 Table 7. Proteins that Most Closely Match to the Deduced Amino Acid Sequences Coded by Clone 38516 Using BlastX Analysis.
Nucleotide Matc hing Se uence Restion Gene Accession Identity # I value 970-1, 884 _ i 1167926 127/305 l e-59 2,231-2.268 HCMV UL144 11167929 54/146 3e-18 3,122-3.361 HCMV UL145 11167930 52180 ie-22 3,584..4,015 cadherin-related tumor 014097 23/85 0.23 su ressor 4,095-4,343 al ha chemokine human 0586 31/83 0.015 4,583-4,807 GRO human P09341 28175 1.5 4,938-5,198 53/87 8e-23 5,469-5.795 45/109 Se-09 The deduced amino acid sequences of the potential ORF that comprised the 4 regions of clone 38516 that matched to a cellular chemokine gene, are shown in Table 8. The sequences differ significantly from each other, and to varying degrees, from the amino acid sequence of the MGSA/GRO-alpha precursor protein. Also shown for comparison is the amino acid sequence of the closely related alpha chemokine, macrophage inflammatory protein-2-alpha (Gro-beta). The alignments for 3 of the sequences were obtained from the BlastX program. The amino acids that match to those of the MGSA/GRO-alpha precursor protein are underlined. The cystines involved in disulphide bond formation are indicated with an asterisk. Sequence 2 contained an apparent insert that separated two closely matching segments. This insert is shown beneath the site separating the matching segments.
The initial codon for this insert was a stop codon indicated by the # symbol.
The 4'" sequence did not match to MGSAIGRO-alpha, but rather, as noted in Table 7, to a more distantly related human alpha-chemokine.
The sequence analysis shown in Tables 7 and Table 8, is consistent with a genetic recombination between a portion of the SCMV-derived stealth virus that encodes several eytomegalovirus related proteins and a region of the cellular genome that encodes a protein with chemokine activity. The data emphasize the value of obtaining sequence data on stealth virus isolates, and the potential that exists for stealth viruses to transmit potential oncogenes.

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It is unlikely that the chemokine genes were present in the original SCMV from which the stealth virus was derived. The HCMV Toledo strain in which the UL144 and UL145 coding genes have been sequenced, continues with sequential genes that code for proteins designated UL146 to UL 148. While the UL 147 proteins of both the Toledo and Towne strains of HCMV
do show weak and statistically insignificant (p value 0.15), homology to an alpha chemokine of guinea pig origin by BlastX analysis, the common sequences show very little overlap with those coded by the 38516 clone. Moreover, this would not account for the multiple copies of the human chemokine related sequences in the stealth virus. Additional differences between the stealth virus and HCMV clinical isolates include the lack of UL142 and UL143 genes. Further clarification of this important issue should be forthcoming from sequencing studies on SCMV isolates.
The previously alluded to genetic instability of stealth virus-1 genome may account for differences seen in the 4 regions of clone 38516 that matched, by BlastX
analysis, to the MGSA/GRO-alpha chemokine. One of the regions clearly has a major insert, while all have apparent deletions. Slightly less statistically significant amino acid matching of two of the regions occurred with macrophage inflammatory protein-2-alpha chemokine, also known as GRO-beta. This was not unexpected since, as shown in Table 8, there is a strong homology between this protein and the MGSA/GRO-alpha chemokine. Other members of the superfamily include macrophage inflammatory protein-2-beta (GRO-gamma), neutrophil activating peptide/IL8, platelet factor-4, beta thromboglobulin and interferon-inducible protein- I 0.
The human MGSA/GRO-alpha chemokine gene has been more extensively studied than the other chemokines because of its possible role in the autocrine stimulation of melanoma cell growth.
The 1,895 nucleotide MGSA/GRO-alpha gene comprises a 5' non-coding region containing NF-kappaB, HMG(1)Y, IUR, and Spl binding sites. It has 4 exons and 3 introns. The first exon codes a signal peptide (nucleotide 130-229) while the second, third and fourth exons comprise the mature protein (nucleotides 330...451; 565...648, 1 l 80- I 195). A long non-coding 3' end extends from nucleotides 1196 to 1895. cDNA sequences of the MGSA/GRO-beta and MGSA/GRO-gamma genes show extensive homology with the mRNA sequence of the alpha gene. A
pseudogene has also been identified with homology covering the 5' non-coding region, the first and second exon and the first intron of the MGSA/GRO-alpha gene.
The absence of intron sequences in the assimilated MGSA/GRO-alpha related regions of clone 38516 indicates that the putative recombination event occurred at the level of RNA, rather than at the level of genomic DNA. The fidelity of replication by reverse transcription is generally less than DNA dependent replication. This may help explain the greater divergence seen when comparing nucleotide sequences than when comparing amino acid sequences. At the same time, the apparent amino acid conservation, especially with regards to the capacity to form disulfide linkages (as indicated in Table 8), suggests that the proteins are providing some positive selective pressure. It has not been established, however, that any of the chemokine related coding sequences are being transcribed and translated into functional proteins.
The patient from whom stealth virus-1 was isolated has not developed any malignancies. As discussed below, evidence for stealth viral infection has, however, been obtained from a number of cancer patients and From several animals with various tumors. Useful information should be forthcoming from sequencing studies on stealth virus isolates from these cancer patients.
Positive Stealth Virus Cultures in Cancer Patients Multiple myeioma: Viral culture techniques were used to screen patients with multiple myeloma for stealth viruses. This inquirv_ was prompted by a woman who had previously tested positive, as had her son, informing me that her father had developed multiple myeloma. It turned out that he had been depressed for several years with many of the same symptoms experienced by his daughter and grandson. He tested strongly positive, as have over 100 additional patients.
On careful clinical review, it is apparent that significant emotional and cognitive difficulties and sleep impairment, are remarkably common in patients with multiple myeloma.
Breast cancer: Several patients have had either their blood or tumor sample tested using the viral culture technique. Again, it has been surprisingly easy to obtain positive, transmissible CPE, from these patients.
Other cancers: The daughter of the multiple myeloma patient developed a uterine cancer. An medical office worker with a prior clinical~history of Lyme disease developed a melanoma on her finger. She, as well as her ill husband, gave strong positive stealth virus cultures. Additional stealth virus culture positive patients have developed lymphomas, brain tumors, thyroid cancers, salivary gland tumors, etc.
In addition to viral and cellular sequences, the data on clones generated from the prototype SCMV-derived stealth virus indicate that the viral replicative process can extend to the incorporation of genes of bacterial origin. Indeed, there is good evidence for bacterial-derived sequences in at least 8% of the DNA clones derived from stealth virus- I infected cells. As outlined above, the inserts in 180 clones of the 3B series and in 120 clones of the C 16 series have been partially or completely sequenced. Of the 300 clones, the majority have at least a portion of their overall sequence that is homologous, by BIastN and/or by BlastX analysis, to the HCMV and/or SCMV
genome. Other regions of the same clones and numerous additional clones, contain sequences that do not correspond to HCMV and/or to the limited known regions of the SCMV genome. Of these non-matching clones, 24 contained sequences that by BlastX analysis, could be partially matched to different protein sequences of bacterial origin. An additional clone had a nucleotide sequence that was similar to a bacterial ribosomal gene complex. The bacterial nucleotide and protein sequences that most closely matched to the sequences contained in the various clones derived from the stealth virus-1 infected culture are summarized in Table 9. For many of the matches, additional bacterial sequences were also identified, usually comprising groups of functionally similar entities.
Several clones contained non-overlapping nucleotide sequences that, when translated by the BIastX program, could potentially encode amino acid sequences that corresponded to portions of quite distinct proteins, not known to be coded by any contiguous set of genes in bacterial genomes, and in some cases, seemingly derived from widely divergent bacteria. For several clones, the matching with a particular bacterial gene occurred in discrete segments separated by variable size gaps. The degree of identity and the corresponding statistical "p" values for each of the matching segments are shown in Table 9.

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The data presented in Table 9, indicate the existence of bacterial-related sequences in cloned DNA extracted from the stealth virus-1 infected culture. The diverse range of bacterial species identified using the BlastN and BIastX programs, argues strongly against the bacterial DNA being a contaminant of the cloning process. The high levels of identity also exclude the possibility of diverged herpesviral sequences being mistaken for bacterial sequences.
A flanking sequence in clone 38313 matched to the human C-C chemokine receptor, which in turn matches to the G-protein coupled receptor coded by the US28 gene of HCMV. With this possible exception, the demonstration of a viral sequence followed by a bacterial sequence in the same clone has yet to be documented. This can clearly be inferred, however, from the information provided in the Footnote to Table 9. Specifically, near identity was observed between a stretch of clone 38313 and a sequence contained in clone C 16246 which aligned to the HCMV gene coding the US28 protein. Moreover, additional regions of clone C16246 show a strong homology with several HCMV
coded genes. Similarly, the limited overlap between clones 38513 and 38525 is informative. Beyond the overlapping region, clone 38525 shows highly significant matching to HCMV.
The overall sequencing data are consistent with variable patterns of recombination between various sequences of viral, cellular and bacterial origins.
It could be argued that the bacterial sequences have, in fact, incorporated viral sequences, rather than the reverse. When dealing with obligate intracellular microorganisms, the distinction between virus and bacteria is somewhat irrelevant. This is especially so when several of the functions ascribed to the bacteria, are in fact, mediated by bacterial plasmids and/or subgenomic insertion elements. The predominance of virus-related sequences, and the lack of bacterial structures seen on detailed electron microscopy of stealth virus-1 cultures, strongly favor the notion of a virus with assimilated bacterial-related sequences. The term viteria is proposed for a eukaryotic virus which has incorporated genes of bacterial and/or bacterial plasmid origin.
Many of the matching bacterial sequences correspond to genes involved in rather unique energy generating and metabolic conversion reactions. Particularly, noteworthy are sequences contained in genes that participate in the transport, , activation and/or synthesis of uncommon metabolites. Given such a wide array of metabolic functions, it is conceivable that viteria could maintain a limited capacity to metabolize, and possibly even to replicate, outside the confines of a cell.
Certain bacteria could derive a competitive advantage by being infected with a viteria that encode functionally useful genes. The improved metabolic performance of a viteria infected bacteria, (or an infected fungus), could facilitate transmission of the underlying virus infection. Conversely, some of the pathogenicity of stealth viruses for human and animal hosts, could be mediated by toxic byproducts of the various metabolic pathways encoded by the assimilated bacterial genes. Toxic products have been detected in blood, urine and cerebrospinal fluids of stealth vinrs infected patients, and also in the supernatants of stealth virus cultures (unpublished).
Supernatants from mixed bacterial cultures, obtained from a stool sample of the patient from whom stealth virus-1 was originally isolated, also induced a vacuolating CPE in cell culture (unpublished). In addition to oile or more toxin, the supernatants contain a filterable cytopathic agent that can be passed in tissue culture.
Molecular studies on this agent have yet to be performed.
*rB

The presence of bacterial-related gene sequences in the stealth virus-1 culture has relevance to diagnostic microbiology. Positive PCR based assays, using primers reactive with various bacterial sequences, have been reported in patients with chronic fatigue syndrome, Gulf war syndrome, chronic Lyme disease, Alzheimer's disease, multiple sclerosis, arteriosclerosis and other diseases. These reports may reflect the presence of limited bacterial-related nucleotide sequences contained within an essentially viral pathogen. Minor differences in the ribosomal sequences of bacterial species have also ied investigators to use PCR to classify the postulated bacterial pathogens that were presumably being detected. The BIastX findings showed an even better matching of amino acid sequences than nucleotide sequences. Viteria encoded proteins might be expected, therefore, to evoke antibodies that could be misinterpreted as evidence for infection with conventional bacterial pathogens.

industrial Applicability The detection of nucleic acids in stealth virus infected cultures, and in clinical materials derived from stealth virus infected patients and animals, has provided new insights into the molecular heterogeneity and potential derivation of stealth viruses from both viral, cellular and bacterial sequences. The utilization of molecular based probing and genetic sequencing expands upon the capacity of culture based techniques to detect stealth viruses and provides a method to distinguish between stealth virus isolates. Sequence determination of a given stealth virus can be useful in relating abnormality in specific gene expression and the clinical disease manifestations. For example, it is expected that the stealth viruses isolated from patients with multiple myeloma may have incorporated and lead to aberrant expression of a B cell growth promoting cytokine such as interleukin 6. This possibility can be determined using the techniques outlined in this application. The determination of stealth virus-isolate specific sequences can be used epidemiologically to trace disease transmission.
This approach can be applied to the stealth virus epidemic currently being studied in patients in the Mohave Valley. PCR based assays on patients' blood and CSF samples using primers reactive with previously isolated prototype stealth virus were clearly useful in documenting infection in the patient who died with a cerebral vasculitis, the comatose patient with a prior history of a bi-polar illness and in the health care worker in whom probing of her stealth virus culture for atypical RNA sequences yielded positive PCR results.
The application of this research extend well beyond the field of medical diagnostics. To address this area first, it has been extremely useful to perform stealth virus cultures in patients presenting with severe neurological illnesses of uncertain etioloiry. In previously published papers and in a clinical paper recently accepted for publications, the positive stealth virus findings have prompted clinicians to introduce anti-viral therapies, such as ganciclovir. An extensive outbreak of stealth virus associated illnesses was recorded within the Mohave Valley region of the United States. The illnesses in many of these patients began with a gastrointestinal disorder, possibly transmitted via stealth virus infected bacteria. Several adults have died with multi-system illnesses, including signs of progressive encephalopathy. An accepted publication describes a 7 year old boy from this region in whom two brain biopsies were performed. The biopsies showed marked vacuolization, not unlike that seen with brain diseases attributed to priors. Interestingly, for over 7 months, his illness was simply attributed to attention deficit, oppositional defiant behavior, etc. Even his parents, both of whom are physicians, failed for a long time to see signs of an organic illness. His MRI was grossly abnormal, yet his clinical neurological signs were initially quite minimal. He eventually became clinically severely ill, being unable to walk and suffering severe headaches. Yet the concept of a virus encephalopathy was still not considered by specialist neurologists, who favored a degenerative process.
Following the successful culture of a stealth virus from brain and cerebrospinal fluid, the child was beLUn on anti-viral therapy 9ganciclovir). his downhill clinical course began to stabilize within the second week of treatment.
Multiple other patients, variously labeled as having chronic fatigue Gulf war syndrome, Lyme disease, amyelotrophic lateral sclerosis, schizophrenia, depression and dementia, have been begun on ganciclovir on the basis of a positive stealth virus culture. Ongoing studies have also focussed on patients with various malignancies, and on patients thought to have a prior associated illness.

WO 99/34019 3~ PCT/US98/27744 The identification of a stealth virus infection will be aided by sequence informarion pertaining to the particular virus isolate. This will help remove subjective uncertainty that can result from always distinguishing a toxic effect from a viral cytopathic effect. It will help define the origins and composition of a particular isolate. It will help identify patterns of disease transmission, for example between family members and within a workplace environment. The possibility of disease transmission via blood and other biological products, and even in foods and from other environmental sources can be effectively explored when one has sequence data to help tag and quantitate the virus.
Sequence data can also assist in understanding the replicative processes employed by various stealth virus isolates. While some viruses, may replicate primarily through a DNA dependent DNA
polymerase, there is evidence for reverse transcription of RNA to DNA. This is relevent to the content model in which fragments of RNA are possibly being assembled on pieces of DNA
forming a type of scaffold. Such speculations will be refined by knowledge of actual sequence data. More importantly, this model needs to be tested in terms of whether shorter pieces of nucleic acids could potentially disrupt the putative scaffold and lead to cessation of viral replication.
The sequence data themselves are also useful since they relate to overall functions of the stealth viruses. This is seen particularly with the cellular and bacterial sequences that can apparently become assimilated into the viral replicative process. The sequence data can also define antigenic targets for potential antibody production, both as adjunct diagnostic agents and as a possible means to evoke in vivo protective antibodies that may prevent viruses entering the brain.
While stealth adapted viruses are mainly being viewed as pathogenic agents, they may also find beneficial scientific and commercial uses as potent vectors for the transfer of genetic information.
Both the viruses themselves and the various genes identified through sequencing efforts on stealth viruses, should find widespread applicability,, especially if species barriers do not exist for at least some of the isolates.
Finally, the discovery of stealth viruses and an understanding of their sequence composition has led to a series of publications, some of which have been summarized earlier. A listing of the major publication, including several that are "in press" is as follows:
Martin W.J. Detection of viral related sequences in CFS patients using the polymerase chain reaction.in "The Clinical and Scientific Basis of Myalgic Encephalomyelitis Chronic Fatigue Syndrome." Byron M. Hyde Editor. Nightingdale Research Foundation Press.
Ottawa Canada pp 278-283, 1992.
Martin W.J. Viral infection in CFS patients. in "The Clinical and Scientific Basis of Myalgic Encephalomyelitis Chronic Fatigue Syndrome." Byron M. Hyde Editor.
Nightingdale Research Foundation Press. Ottawa Canada pp 325-327, 1992.
Martin WJ, Zeng LC, Ahmed K, Roy M. Cytomegalovinrs-related sequences in an atypical cytopathic virus repeatedly isolated from a patient with the chronic fatigue syndrome.
Am. J. Path. 145:
441-452, 1994.

Martin W.J. Stealth viruses as neuropathogens. College of American Pathologist's publication "CAP
Today" 8 67-70, 1994 Martin WJ. Stealth virus isolated from an autistic child. J. Autism Dev. Dis.
25:223-224,1995.
Martin WJ, Ahmed KN, Zeng LC, Olsen J-C, Seward JG, Seehrai JS. African green monkey origin of the atypical cytopathic'stealth virus' isolated from a patient with chronic fatigue syndrome. Clin.
Diag. Virol. 4: 93-I03, 1995.
Martin WJ, Glass RT. Acute encephalopathy induced in cats with a stealth vinrs isolated from a patient with chronic fatigue syndrome. Pathobiology 63: 115-118, 1995.
Martin WJ. Severe stealth virus encephalopathy following chronic fatigue syndrome-like illness:
Clinical and histopathological features. Pathobiology 64: I-8, 1996.
Martin WJ. Stealth viral encephalopathy: Report of a fatal case complicated by cerebral vascufitis.
Pathobiology 64:59-63, 1996.
Martin WJ. Simian cytomegalovirus-related stealth virus isolated from the cerebrospinal fluid of a patient with bipolar psychosis and acute encephalopathy. Pathobioiogy 64:64-b6, 1996.
Gollard RP, Mayr A, Rice DA, Martin WJ. Herpesvirus-related sequences in salivary gland tumors.
J. Exp. Clin. Can. Res. 15: 1-4, 1996.
Martin WJ. Genetic instability and fragmentation of a stealth viral genome.
Pathobiology 64:9-17, 1996.
Martin WJ, Anderson D: Stealth virus epidemic in the Mohave Valley. ! Initial report of viral isolation. Pathobioiogy 1997; 65:51-56.
Martin WJ: Detection of RNA Sequences in Cultures of a Stealth Virus Isolated from the Cerebrospinal Fluid of a Health Care Worker with Chronic Fatigue Syndrome.
Pathobiology Martin WJ: Cellular sequences in stealth viruses. Pathobiology 1998;6b:53-58 Martin WJ: Bacteria related sequences in a simian cytomegalovirus-derived stealth vinrs culture. Exp Mol Path (in press).
Martin WJ: Melanoma Growth Stimulatory Activity (MGSA/GRO-alpha) Chemokine Genes Incorporated into an African Green Monkey Simian Cytomegalovirus (SCMV)-Derived Stealth Vinrs.
Exp Mol Path (in press).
Martin WJ Anderson D. Stealth virus epidemic in the Mohave Valley: Severe vacuolating encephalopathy in a child presenting with a behavioral disorder. Exp Mol Path (in press).
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SEQUENCE LISTING
<110> Martin. W. John <120> Stealth Virus Nucleic Acids and Related Methods <130> CCID-2 <190> US
<141> 1998-12-29 <150> 09/001,189 <151> 1997-12-30 <160> 94 <170> PatentIn Ver. 2.0 <210> 1 <211> 2142 <212> DNA
<213> Stealth virus <400> 1 gaattcaaaa aagaaatcga aaatcaaatt tttggtaacg aagtcaaaaa tgtttctaaa 60 taactttaag ccctatttta tagggttttt agtttaaata taaattatag aatttaaaaa 120 aatttattgg cgaagataac aaaattaatt tttgggttga aaaattttct atgtaacata 180 taaatattaa taacgaaatc atatgtaaaa aacaaaagca aaaaaataaa taattattat 290 tgcaacatct attgcatgat aatatgcatt cttagtccca tcaaatcatt catggggata 300 caagcatcta tttgtaattc atcactaaaa tgcatgtttt cttttctgca taatctaact 360 cttagtctta cttcgctaaa caagcctaaa aagttttgat aattgtttct aacatcttct 420 atttggactt ttaacaattc agcaatttta atcatttttt tacttttctt ctcgttttct 480 tatggttaaa actcctaagc ttgttaatct gttaactaaa gtttgataac taatttattt 590 ttcatagcct tcatgagaat aatctccaac ttttatttct tttcaaaaag atttgattgt 600 tgcatcatta acatttttga ttccgttagt tctattttta gaaacaattt gaatagcatt 660 ggtttttcta tttaaaaaat ctctaatatg gcttttgtat ctttgaatag atataattga 720 taaaccaact tttttagcaa tttgtcaatt actcaaattc attcaaggtg caattaattg 780 atagtttttt gtttgctttt tccaattttg ctggattaga acaaaaacta aatactaaat B40 caataaatac atcctatttt acaattataa atgtcaaatt gttttgtatt gaaggtatga 900 caaactattt tagaatttat atcccacttg ttatttctta ttacttttat attttaataa 960 tataataatt ttaataatat attttgattt ttatcagtag aatgaggtca ttaatatgac 1020 aaaagaaaac aaaactttaa atattctttt tattggggat attttttctg aagcaggaat 1080 tgaaatagtt gaaaaacatt taccttcttt aataaaagaa aataaaatcg atgttgttat 1140 agcgcaaagt gaaaatgttt caggaagaaa aggtttagtt aaaaaagatt atttaagact 1200 taaaaaagca ggtgttaata tttttacaat tggaaaccat gtttgagcta aagatggaat 1260 tttttcaata atcaataatc ctgaattagt tagacctgct aatatagatg aaggatatcc 1320 aggaaatgga tcaatagttt ataaatgtaa taatggaact actttaagag ttacttcatt 1380 aatgggaatt acttttaata aactattagc cccttgaact caagaatatg ccaataactt 1440 ttttgatact atagataaca tcattgaata tggagaaaaa actgattttc actttgttga 1500 ctttcacgct gaaacaacaa gcgaaaaata tgttttaggt ctttatttag atggcaaaat 1560 tgatggtatt tgtggcactc acacacatgt gcaaactaat gatgcacatg tgctacctaa 1620 ggggacttgt tatttaacag atgctggaat gagtgggcca tttgattgtg ctattggagc 1680 aaactttgat gaagtttatc aaaaaatgag atataacaag aatgttaaat tcattccttc 1740 aaaaaacaaa agccaattta atggtgctat attaaaacta aatagtgaca aaagccaaaa 1800 caaaattatt ccaattaaca taagacaaga ataaaaaatg atataactag ttcaagcttt 1860 acataggtaa agctgcaagt tagtcaaaga gcttggctat tagactaata tatgtgttac 1920 taatgaacaa gacaaatgtg cttgaatcaa tggaccaaca ttgagggtgt agactcttgc 1980 attgtatagt aagtgatttt aagtggtatt ctttaccgct atttttttac aatttattat 2040 aaaatttgca aagataaaaa agaaataaaa attatgaaat atccaaagtc ttttgttgat 2100 tttactaata ttgatgttga tttagaagct agtaatgaat tc 2142 <210> 2 <211> 854 <212> DNA
<213> Stealth virus <400> 2 gaattctntn ntnnagaanc tcctcgcnng tgatgcgaat gttgcccgaa cactgccgat 60 cncacacact atgctcgtag atnaacggcn atcgncttcn cggaacnntg ncgcctngcn 120 nnatngncta tcaacanatt gcnanncttn gnnggcttng aggtangacg cggaatttgg 180 agcagtcccc gaacgggttt tggcgcgtac gcagcttccg taactatgca gactatgctg 240 ttgagtgcgc cgtttgccga cggacttgcc caactcaggg cgctaggaaa caaacaccgc 300 tgcgcaatca tgtgtgcaga ggctgtatgg tggcgctgtc atcggcggat catnacggac 360 tacctganca gccaaggcga aagcgtgatg cacatcctgg ggtcatcgna agtcaatgag 420 gccagcatga cgcctggagc tgtcatgaat ggggaaggtt taatttatcc agcccgaaag 480 tgatatacga nnaatagtgt tagtgatttc gtctcgaata ttagctttta ccccgctggc 540 ctgggtgtcc ggtttaccag catcttggcc ccagaaattg tgaatcgaag gaattaccat 600 tgcattccca cggaccacnn attggcntgn ttgcctttcc gangggngtt tgccgttccc 660 cgcnttttaa ttagtngggg cttaaaaact atttngnccc tgttttccna ccaaggtaan 720 tttaccaacc ccttttacct ttnaacaact ttcggggnaa taaggggccc taattgggnc 780 ntgntggggg ntncccnntt nggggggggt tgggcanttt ttttggggaa ttngngggac 840 caagggttgn aanc 859 <210> 3 <211> 809 <212> DNA
<213> Stealth virus <900> 3 gaattccatc caggcttttg cttacagcct ggacttccag actcagctgc aaaagattcg 60 cgacctcaag gcacgctttg ccgatctgat taagcagcag catctcaacg cgtctgaaga 120 agtaccctta cccatgcccc acctaccagg aaacacggtc atngcctccc cgctgtcgtt 180 tgccaagggc ctggccgccc tagagaaata tgttttgggc ggntaccagt ggttaaccga 240 atgtatcaac cgtcaacctc tagtgtgtca acgcatagac gacattccgg ccgttttgcc 300 gtcaaccgat attgaccgca agagagtcgc cctagatcgc ctcaagcggn tgagttttag 360 tacaaagaac gaaatgtgtt acgaagttgt cgacgtattc ggnctccacc aactcatgtc 42C

caaaaatggc gttcccatac actttgnact gagctacgga aacgtgtttt tcaagtacat 480 ggcactacat cacgatgatn agcaattggc aaaaaaattt gcccaagtta aaaatttggt 590 gactggcagg atacaaagtg gtaacggtca atggtcgcnc gtancccaga ccttggaaaa 600 ccttctggtc ccaggatatt cccaatnccg aaccttnaaa ccccttactt ttcaggtcaa 660 aaccacttca ntanggtttn aagggaagaa aacttaacag tcttagtana acccttnaaa 720 aaatttttca nttttnatna tttggncggt aattcaagcc ctgggnaaac ttgggcaaan 780 tttgggaatg gtggcctttt naanggaaa 809 <210> 4 <211> 817 <212> DNA
<213> Stealth virus <400> 4 gaattcggtg ttaaaatctt ttattttgat tataaaattg cgggagttaa aggcggttta 60 tattttcctt tattaactag tttgataatt tgcatattgg ttttatttat tagttgtcct 120 atttctttga gggttgcaat cttaataatt tatcgaaata aaaactataa agcttatcga 180 acatttaaat ttatggcttt aattttaagt gctttgcctt ctgttttata tggacttttt 240 ggtttagtac ctttgacttg aatgaacaaa aatatattta atatggaaaa tggaacaaac 300 ttatttaatg ccacaatggt cttaagttta atgtgcattc caactatggt caactcatta 360 ttattgcaat ttgaaaaagt tgatttatgt ctaaaactct caggtagtgc tattggttta 420 agcgaatcaa aagtaattta taaaataatt aaaaagtcat taaacaaaaa aatattttta 480 atttatatta gctcttttgc cagagttatc ggtgaatcag ctgctttaat gtttatttta 590 aatagcaata attattcaga aaattttaca aatattaaga aaatttttta actcttcatt 600 gcgtnctctt tcagtattta ttaatgctaa tttctttgct ggaaaatggt gggccgaatg 660 caaacctagg aagttaccat gtttaaattt aagctttttg gntcttatta aattngggga 720 ataacctttt aatttaaatg gctggcnaat tcattaattn atttggttaa attttcaaaa 780 aaggtccaaa aaaaaaccct taaannggan tttangc 817 <210> 5 <211> 834 <212> DNA
<213> Stealth virus <400> 5 gaattctaga ttgatatttt ttagaatttg tttacctttt ttgttgtatc aaaagttaac 60 attttctaat ttaaaaattg tatttttttc catatttact cctaatgttt tctttttaat 120 ttgcttaatt ttggaatcac aaattctgat aatgataaga ggatagttat tgttacaaat 180 gacaccatag cacaatagta catagttgga attgagtaag ctgaaggcaa tgataattga 240 gcattcattc tagtcgttaa tgtttggcca aataataata agctaatatg ttttgaatta 300 cttagtccgc tagttaaaat aaatggtgtt gtttctgaaa agattttagc cagcattaaa 360 ataataatat ttaaaagatt aggccaaatt ttaggtaatt ttattttgaa taaaattgca 420 ctttcgctga gtcctaaagc agctgcacta gttactacac tttgatcaac tatttcaagg 480 agcttcttta attcagcgac agctaaaggc aaataacata acgctaattg ctaaagctcc 540 agctaaaagt gagttactgg ttttaccacc taaagccaat tggaaaagtt cctaaaaaga 600 tagctgaacc caaagacacc caaaaagatn aaaccaggcc attggaagtc attaacctgg 660 aaatggaagt ttattcaaaa taccttaaat tttgcttttt tttgcttttt ggttaaaatt 720 caacccaaaa ttaaattggt taccttaaaa aaaggccnaa aaaggggaaa ggtttaccta 780 aaaaattggc ttcctaaaag gaggattttt ttnaaggggg ttnaaaatna aagc 839 <210> 6 <211> 846 <212> DNA
<213> Stealth virus <900> 6 atttnnnnnc ttgaannccc tngnctcaat cagtggacca ttaccgatgc gcaggggctt 60 gatacgacgg tgatgatctt caatctgcgt acgggtgtac gtttcaccga tgatatgttc 120 aagatcgact atcagcgcat cgcgatgaaa cgaaaaggtc agtaatagtc agcttagagc 180 ggttccagtt aaaattgaat cgttggattc gctctatctg cctgtttttg cgcgcatctt 240 atccgaaaac cgtttcacac ttttcgagat gcgctttagt tgctgcctga tgtttgcatt 300 ttttggataa atggttaggt tcgcgaccat cttttgatga ccgcgagtct ttttcccatg 360 accttttctg ttgctacctg gaacatcaat tccgttcgcc tgcgcatgcc gctggtcgag 920 cagttcttga gcgattatca gcctgatgtt ctgtgtctgc aggaaaccaa atgcccggac 980 gatcaattcc cttccaaggg ttttcgtgcg cttggttatg agcatatcgc gatcangtgg 590 tcagaagggc tatcatggcg ttgcaactat ttccaagcgc ccgctgannc gatgtcanan 600 aagtancggc ttttgcgaaa tgggcgactg ccgccatnct naagccgcgg tttgttttca 660 agccggcgac aanaaangct ncgtatccca ttaaatttcc tacngtnccc ttgtctgggc 720 cnnttgaatt gantcccggg gaccccgggt tnatttnaat ccccaaaaat tttggcgcca 780 ttaaancctc tggntttttt ctttggaagg gnaaaattgc ccaanccgaa attgtngggc 840 acgtaa 846 <210> 7 <211> 774 <212> DNA
<213> Stealth virus <400> 7 gagctcctat taaagcattt atagaaaaag tgcgaagcgg ttttgcatag gataatgcga 60 aagaaaatag atagagcggt tccaacgact aagtcttaac ttgaaccgct ctgatattcg 120 ttcgccgcct taataatagg tatatgcggc caaacattgt tcactagcgt cagattacag 180 agccgttgct ctgtaatagc ttattaccat tgatcttaat ccagatcaaa tgtcgcgatg 290 acaggcacgt ggtccgaagg acgctcccag ccgcgcgcct nacgcagaat ttgcagctcc 300 ttcatatgag cttcgagatc agcagagccc cagatgtggt caagtctgcg accacggtca 360 gcggcgtccc aatccttggc gcgataactc caccatgtat aaatcttctg gtctgctgga 920 atgacctgac gcatcaanat cgnttccagc nacncttcac acgcagatct tccagcgttg 480 tggtctcaat ccggtgtgtg gctgacgatt cttgganaaa ngctgtttgt gcggaccagg 540 acattcgtnt ttttncnaag tggggcngcc gaataatttg atgattcgnc cccacccagg 600 gaatccggac cnnaaatttt cccnttcctt gcccttgttc ttgcccacca nattcncctt 660 cggctatttt tncnttcaag cgnaaaaaac cntangcctt taatgncgnc canaaattnt 720 ttgggnnatt ttaaatttac ccnggggttt ccnggtcttt aantnaancc gntc 779 <210> 8 <211> 1694 <212> DNA
<213> Stealth virus <400> 8 gagctcggaa ttcataacgc tttttatgtt cgccacgatg atggtgctgc tgatgacggg 60 tcagcgcgtc ttcggcgtga tcggatttgt gggcacaatc gccgcacttc tgctctgggg 120 caaaggctcg ttcgagatgc cctacaatgc cacattcgcg gtgttgaatt ggtatccgct 180 cataaccgtg ccgttctttg tattcatggg ctatatgctg tcggaatccg gcatcgccag 290 caatctctat cgtatgttcc atgtgtggtt tggaggcatt cgcggcgggc tggccttggg 300 caccatcggc ctgatggtca tcatttcctg catgaacgga ttgagcgtcg ctggcatggc 360 aattggtgca accgtcgctc tgcctgaact tcttaagcgt ggttataaca aggttatggt 920 gacaggcgtc attcaggctg gcagttcact cggcattctg atcccaccaa gcgtagtgct 480 ggtactttac gccatgatcg cccgacagcc ggtcttgcag ctctggctgg caggcatcgg 540 cccaggcttg ctgatggcag cacttttcgc catctacatt tacatacgct gccgcataaa 600 tcccgagctt ggaccgacct tgcccaagga agagctggaa cggattacct ggggcgaacg 660 catctcgtcc ctgcgggtgg ggctacttcc acttgtcatc tttggcacca tgatggggct 720 gtttctcacg ggtgttacaa gcctcgttga aagctcagcc gttggtgctc tgctggcaac 780 tctcgcagcg ttgttcagca agcgtctgac gaaagttgtt tgggagacca cgacacgcaa 840 tacgctgacc atcacctgca tgttcctctg gatcattctg gcggcccttt gcttctcgtc 900 ggtctatgac ggtcttggcg cggtcaaagc aatcgagcgg cttttgcttg gtacttttga 960 tttgtcgcct tggacgattc tgatcctgat gcttttctct ttcatcatat tgggcatgtt 1020 cctcgatgac accgccatgc tggtcattgt ggcacctctg tatatcccgt tggtgaagag 1080 ccttggtttc aatcccatct ggtttggcat tctctatacg atcacttgtc agatcgcgta 1140 catcacgccg ccattcgggt acaatctctt catgatgcga gcgttggcac caaaggatgt 1200 gacgctgatg gatatttatc gatccatcgt gccattcttc ttcctcatgg tgctgaccat 1260 tatcattctg atgatctttc cacagatcrc gatgtggttg cctaactggt acatgggccg 1320 ataacaggat ctcgaaggga gaacgcataa gcatgaacgg tcaaaagagc cgctaatggc 1380 caagccgtta aaatagcagg gaacttcaaa cacttaatgg gagaatgggc atgagtgaga 1440 ataacaagct taacaaacgc gactttctca aaaaggccgg gctaaccact gtcggtgcca 1500 ttggcgccac gacacttgca acgccttatg tgcgggctca gagcccaatc aagtggcgtc 1560 ttcagaccta tgcgggtccg gcactcgcag aacacgtcat caagccgtct atcgatgcct 1620 tcaacaaggc agcaaatggc gaaa 1649 <210> 9 <211> 9915 <212> DNA
<213> Stealth W rus <900> 9 gagctcgaac gttcgggaag atgtcatgag aaagccgcct tgctgtgatg aagaacttgg 60 tcaagtctcg gcgcacggcg ttgctccaac aatcatcaga atgcactccg atgggcacgg 120 aaatgcacga gattgtctac cggccgcctc ttgcgatgac ggtgcgcaaa gacatcgctg 180 tggtgatgtc attgacaccc ggtagagccg cgaccatggt ccagacgtct tggatgcgtt 290 cgggtgagag ggcttccact cggacaacca agtcaagttc gccagccacc acgtcgcact 300 gcacgacttc ggggatttgt tgaagtgctg cgagaacatc ggcgccgcgc atccggtcct 360 gtcgatagac _gagcatggtg gcactcaccg gcggcgctcc gacaggcctt tcctgaatgg 920 tgtagccgag gatgtgcccg tcccgctcta gacgctcgat tcgttgacga acggcatttc 48~) gcgacagtcg tacgatctca ccgagctgcg cgtgacttgt gcgggcgttc tgtcgaagct 540 cgacgaggat cctctggtcg atggagtcaa gcggacgcat gcctaaaccc tccctggtgt 600 accgtcgggc ccgcaccgag ggccgtgcgg gcggcaactt gcacgtgctc tgccagcgct 660 WO 99/34019 PCT/US98n7744 tgcagcgcgc gggactccag agcagcaaac cgtaggtagt aacgttcggt cgctgtcgct 720 gtggacacgc gatggaggcg gcccatctga atttctcttc tcgcttcgta ccgcggaagt 780 aggccccacg cggcgccctc cagcagtagg gctttcgctg cagaggtcga tgccactgtg 890 gatagcgcac ggcccggcga gaaggatgcc gcttcagcga aggcgtgatg gcgagtctct 900 cgtccgcgaa cgatcacggt cggcgcagag gcgaaatctg catggtggac gcctcgcgca 960 atccactggt cgatgaaacc cggggtcgcc accgcgtcga acatccccac gccgagatcg 1020 acggtatgga atccggacat ctcctcagag gaagtggtga tccgaaaagt gatgtcatca 1080 ttcgcaggcg actgaccctt cagcggctca tcgatgatcg tcagatccat cggcgtgacc 1140 gcagcggcgc gcgcgaccgc ggaaagccac accgaaccca gatcgacctc cacagcgacg 1200 gtcgcgcggg ca-cgacaagc gccgtctgac agtagaccca gggtgcggag cgtctccctc 1260 tcgagcatct cggtctgacg agcaaaccga acgatggacg cccccgtgct cgtcagacgc 1320 actggctttg agcgcaccaa tacgacctga ccaagaagag tctccaaagc cttgagccgc 1380 tggctcacag cggagggagt aatgcggagt tcatgcgctg caccgtcgag agatcctgcg 1440 tcagcaacag cagcaagagt gcgggcgaga tcacccggaa gagtggtcat gagttaccac 1500 ctttcccggg tcgcgatgcg agcctgtcga gagcagcaac gcccgctgag gtcacagcga 1560 ccgccgatgc aaggagcact ggtagccagg catccacagc gatgagagtg cccgcggccg 1620 cagtccccag cgacccggcc gtgatcttca aggctccgac ccagacgaag acctgactgc 1680 gcgcagccac cggcgcatac tcgcttcgtg ccgcgagcgt tgcggcgaag aagtacgagt 1790 tcaggattcc ggtgagtgcg tacgccgcga tgacccagct gacgttgccg gagacgaaca 1800 caccaagcag gctcagyccg acgcctgccg cgagtaccgg cattgccttg tccgcatccc 1860 cacggagcgg ccggaccatc acgcccacgg aacccgtgaa gctcccgagg ccgtacgcgg 1920 tggtcaagaa gcctgccgct gcgggtgcaa ccccgaatcg ggtggcccag cgacggygac 1980 tgaccggcaa cacggygacc gacagggcaa ccgcaaccgt gccgtacaga gtgcgccgga 2040 gagggcccga actgagcatc acgcgccagg gtccgccatg gacgcggcac gtyggaaggg 2100 gtaacgtcct ycgacgaggg cggcagcacc ttcaccagaa atgcggtgaa ggcagcgaag 2160 ccggccagca caagaaccgc cccagtgggg tcccacgctg cagcgatgac cgccaccaca 2220 gtagggccga cagtacctcc gataccgtag gtggccacat cccatccttg agcgcggcgc 2280 tgcgtctctc gctcgggtcc ggcgatggcg ggcaggcgag aactgattcc accggtgagg 2340 agggggccga gtgcgccgga tgcgatcagg agaagggccg gaatgcctat ccagacgacg 2400 tcgtagagca cgacggcggc agccaacgtg gcggcatgaa gaacgcaggc caatgcaaga 2460 acgttccgcc catcgcgcgc agtgtccagt atccgcgcga tgaacggccc gatcaggtgg 2520 ggaaaggtga tgcacgcccc caagagaccg gcagcccacg ggggtccacc gacggtggtg 2580 acgaggagca cgacacccac caccgcgcca ccgtccgacg tgcgcgcgag agtcgccgcg 2690 acgacgtatc gtgcgagtcc tccccggcgc ccgtcggacg gctgattcac ggtgtgctca 2700 acactttcga tgccatggca gcagcgacga cggcttcacg ttcggtttca ctgagcccga 2760 caatcggaag cgggagggca ttgctctgcg tcagaccgat gtgctcggcg agcgcggcga 2820 cgactcggag gcttccgtac tgacggttcg ccgcccagag gggctggagc tgccgagaga 2880 tcagctcagc ttcctcatgg tctcctcgtt gcgatgctcg tgtgatcgcc aaggcaggct 2940 caggcaaggt accggcaatc accgagtacc acgcctcgca cccggcattc aggccagtgg 3000 ctgcgagcgc gtcaccggac actccaatgg ttacggcctc aggcactcgt gcacggatct 3060 ccgtgacgcg ccgagtcgcc tcggcaggac tctccggcac gcccggaatc ttgatggacg 3120 caacatgcgg aagtgtcgct actcgggcat ataggtcgtc tgtgaactcg aaatgcgttg 3180 ttcctggatt gtcgtacacg atgagaggca cgtcgaggtt tgcagtgacg gtgctgaaga 3240 gtccgaagac gtcctcctcc gtcagttgtt gatagctcat ggcaggcagg agcaggccag 3300 ccactccagc cgtctgagca tcctctgcga aggccaacac atctcgtgtg cgcagtgccc 3360 cgatgccggc gaagaccggc accgtgcccg ccagctcaag agcgatctgt atggcgctcg 3420 cgcgctcgcg ccggtccagg tacgcatacg atccggtaga gccgagcgca gtgatcgaat 3980 cgactcctga tgcagcgagg tggacgatga tccgagcgaa cgaaatctcg tccaggcctt 3590 catcccgaag cggtgtgagc gggaacgcgc wgagcccgct gaacaatgcg gtcactgtcc 3600 ggtccttcgc gcgccagtga tctccgtccg gtccagggcc garcgkatgt cagcgatgat 3660 gtcgtcggcg gactccagtc ccaccgacag gcgaaggtgc ccgtaggtaa ggaatccggc 3720 cggatagctt tcgcttcctc cgcgcgcgtc cggtccgacg tggacaatga gcgtttcatc 3780 atggccgagg gacaccgccg aggtgatcac accaaggttg tcgacgaagc gattctgcgt 3840 gtcgctgtcg ccgtcaacgg cgaaggcgag catcccaccg aatcctcgtc caccgaactg 3900 tcgcttggcg agttcatgct gtgcgtggga cgcaagaccc ggatactcca cgtaagcaat 3960 gcggggatca gattcgaggt actctgcgac gcgctgcgcg gaggcgaggt gctgcgcgag 9020 tcggagcgga agggtgaccg acccgcgcat gatcatccac gcgttgaacg gggagatcac 9080 ccctccaacg tcgacgacag cgacgtggcg gatgtgctcc accagatcgg agctgccgat 4140 gacagcacca cccatggcat caccgtggcc gttgatgtac ttcgtcagag agtggatgac 4200 caggtctgca ccatccgcca ggggacggta gaacggcggc ggcgtgaacg tgccgtcgac 4260 cgtgaggagc gctcctgctt ggtgtgcgat gtcggcgata ccgcgaatat ctgcgacctt 4320 cgtcgtcggg ttcgcgatgg tctcgacatg gacgagcttc gtgttggggc ggattgccgc 4380 acgcacagcg tcgaggtctc caacatccac gaaggtggcc tcaatgttgt accgctcggg 9940 gaggagttcg gagaacagct tccagacagc ttcgtatgtg acgttcgaaa cgacgacgtg 4500 atccccagtc ttgaggaggg tgaagaagac accgtggagg gcagcgactc cggttgcgaa 4560 agtggcggcg gcctcgccac cgtccatgac ggcgagcttc ctttccagcg cctgctggtt 9620 cgcaccgccg ttgcgcgtgt aggtgagccg gtcagtggca gaccagtcca tggacgcagg 4680 gtcatccgga aggcgatacg agttggccat gatgagcggc gtgcggacag ctccggtacc 4?90 ttcatcgatg gtgttgccgc cgtggaccgc ccaggtaagg aagtccacag tgtcggcgtt 4800 gtgcttgtcg ggtcgagcgg tcatgttggt cttcctccta gttcgttcct gcagcgagaa 4860 ttcgctgcgc gaccgtgatc tggtcgccga gtcggctcag ttcatcgacg agctc 9915 <210> 10 <211> 246 <212> DNA
<213> Stealth virus <400> 10 gagctcgggg atgttgatga gtccggccac cgccgtgaag accatggcgg ccagcgtcgc 60 ctccggcagc aggctgagca caggagcgag gaagagcgcg accaggacgg ccagcgcgac 120 cgtcgtcagc gtcgccagct gggagcgggc gccggctccc tggttgaccg cgctctgcga 180 gaatccgcct gctgcgggca tggccgcgaa gaatgcgccg acggtgttcg ccgccccggt 290 cgcgaa 296 <210> 11 <211> 9192 <212> DNA
<213> Stealth virus <400> il gagctccatg acctttgagc aaatgctatg cgatcaggtc gagtagattg acaaaaaagc 60 agaggaattt ttcgcaaaac tgtcatttgg aagctgattt gggctagccc cccgcttgcc 120 ggatttgcac tgcgagacta tggtgcaacg ccttgcagct attctggcgc ggttaaaagc 180 cagtgtggta ttgtcaggtt ctgtctttat ttctcaggag ttcactgatg ctgaaaggct 24~7 cgattactgc acttgtcacg ccattcgata gtgaaggagc gttcgacgag aaagcttttc 300 gtgacttcgt gaactggcag attgaagaag gcactaaagg tcttgtaccc gttggcacaa 360 cgggcgaaac gccgaccttg tcccatgatg agcataagcg cgtcattgag gcctgcattg 920 aagtagcagc aggtcgcgtg ccggtgattg cgggtgcagg ttccaataat actgtcgaag 480 caatcgaact tgctcagcat gccgaaaaag cgggcgcaga tgcagttctt gtcgtcactc 540 cctattataa caagccgaac cagcgcggcc tctatgagca tttttcacgg gtcgcacgtt 600 cgatctcgat accgctcatt atctataaca ttccgggccg ctccgtcatt gatatgacac 660 cggaaaccat gggcacgctt gtgcgtgatc acaagaacat catcggtgtg aaagatgcga 720 caggcaagat tgagcgtgtt tccgaacagc gcggcacgtg tggcaaagac ttcatccagc 780 tgtccggcga agatgcgacc gctctcggct tcaatgcaca tggcggcgtc ggctgtattt 840 cagtgacgtc caatattgcg ccacgtcttt gcgcagagtt tcaggatgcc tgccaggctg 900 gtgactatgc caaggcactg gaactacagg atcgcctgat gccattgcac aaggcgctct 960 tcatcgagcc caatccttcg ggtccgaaat atgctctgtc gcgccttggt cgcgttgaaa 1020 atgttcttcg ctcgccaatg gttgtaatcg aagcagcaac cgctgagaag atcgatcagg 1080 ccatgaagca cgccggtctc acgaattaga gtatttccag ccaaagtgcg aagcggtttt 1140 gcgttggatg ttggataatg tgtttaaacg agctttcaga gcgtgtttct atgcgatcca 1200 tcagcagaaa atacgctcta aggctgctaa ttttgcccgg ttgagtgatt tttacgctct 1260 tgctcatgcg agagcgtttt catttccggc aatgagcatt atatggtgcc attatgaata 1320 agccgaaaaa ctctcccgcc cgcaaaatgg tcgctgaaaa ccgtaaagcg cgctacaatt 1380 tcgagatttc tgatacgctc gaagctggtc tggttctgac cggcaccgag gttaagtcct 1490 tgcgcgccaa tcaggccaac attgctgaaa gctatgcaag ctttgaaaac ggtgagttct 1500 ggctgatcaa ttcctatatt ccggagtata cgcagggcaa tcgctttaat cacagccgcg 1560 ccgtttacgt aagctgttga ttagccgtcg cgaaatggca cggattttca attcggtttc 1620 acgcgaaggc atgaccgtcg ttccgttgaa gttatacttc aacgatcgtg gtagagctaa 1680 gctggaaatc ggcgtggcgc gcggtaagaa gaatcacgac aaacgtgaga ctgagaagca 1740 gcgcgactgg aatcgcgaga aatcacgtct tctgcgcgat cgtggctgaa gcgaaaatac 1800 tgttcaaaga aaaagagcgc tgaaaggcgc tctttttata aatgatgcaa aagggttcat 1860 gaagttcgaa attatgaagc tgcacgaacc tgacgattgc gcatatcagt agtcttcgtc 1920 aagatcttcg tcctgacgac gctgctgttg ctgtgggcgt tccgaaggat cgcgtccaat 1980 ttcagctttc agcgaaacca gatcgataaa atgatcggcc tgacggcgca attcatcgga 2040 tatcatcgca ggctgtgtcg tcagagtgga aacgacggat accttacgac ccttgcgctg 2100 caatgcttcg gcaagcgaac ggaaatcgcc atcgccagag aagattacga aatgatcgac 2160 ggtgtcggtg agctgcatgg catcgacggt aagttcgata tccatgttgc cttttacctt 2220 gcggcggcct gtcgagtcgg taaattcctt ggctgccttc gtgacaacct tatagccgtt 2280 gtaatcgagc caatcgatga gtggacggat cgatgaatat tcctgatcct caaccagagc 2340 cgtataataa taggcgcgca gcaaatagcc gcgtttctgg aatgccttca aaagtttacg 2400 gtaatcaata tcgaaaccga gtgtttttga agctgcgtat aaattggcgc cgtcaataaa 2460 tagcgcaatt ttttcacgag aatcgaacat cgtgcaatat atccactctg cggccggtag 2520 gragtgggcc tgcgaccgcg tattcagatt tgtttcttaa acggcggggg tattcatttt 2580 taccaatgac gtttattgcg ttctacggag atattataga aaahcaagca accgatggtt 2640 gttatttgat caatcttaat tacttttacg cgatatttcg atatagcaat cgataatcga 2700 tcaaaatcta ttgttccaat ttgatccaga tcgtgtattt gtcagacaga ttaatgaaca 2760 gttgtatctt agcctagatt tctgagcctt gtcgttggtg ttttgcgctt ttgcttgtaa 280 tttcggctca caagcgttat gtgcaagaaa aattccgtta aagtttaaga aatgaaaggg 2880 accgcctatg gcccgcgtca ccgttgagga ctgcgtagat aaggtcgaga accgttttga 2940 actggttctg ctggccggtc accgtgcccg ccagatttct cagggcgccc agatcacgat 3000 cgaccgcgac aacgacaaga acccagttgt cgcgctgcgt gaaatcgctg acgagacact 3060 ttcaccggat gatctgaagg aagacctgat ccattcgctg cagaagcacg ttgaagttga 3120 cgaaccggaa gctgctgctc ctgcccagat caccgatgct tccgatgcgt tggctgaagg 3180 gattgccgaa gctggtgaag acgatgtcgt ttccttcgac cgtatgtcgg aagaagaact 3240 gcttgctggt attgaaggcc tcgttgctcc agaaaagaac gacgacttct aatcgtcgct 3300 ctgctgatca agtatttcag gcaaacgtcg aaatgagttt tgcctcattg~aatacttgaa 3360 tacaaacagg ccttggtttt ttgcgtgcgc ttcggcttcc aggctgtggc gcacgttttt 3420 atgtgcatgg caggctggga attgagatta gcttttggct tgccactgag acgtttgtga 3980 ctgaaattaa gcctgttggc agaaaacagg tccggaaact cgcaaattgt tatatttttt 3540 agtgatttcc gttcaaaatg accgctgcgt acgtgactgg tagggagttt ctgtaaatga 3600 tgcgccaata tgagcttgta gagcgtgttc agcgatacaa gcctgacgtc aatgaggcgc 3660 ttctcaacaa ggcgtatgtt tacgctatgc agaagcatgg cagccagaag cgtgcgtccg 3720 gtgatccata tttttcccac ccgctcgaag ttgcagcaat tctcacagat atgcatttgg 3780 atgaggcaac gattgcgatt gctctcctgc atgacacgat tgaagacacc acagctaccc 3890 gtcaggaaat cgatcagctg tttggcccgg agattggtaa gctcgttgaa ggtctgacca 3900 aactcaagaa gctcgatctg gtttccaaga aggcagtgca ggcggaaaac ttgcgcaagc 3960 tgctgttggc tatttccgaa gacgtgcgcg tgcttctggt gaagcttgca gatcgactgc 4020 acaatatgcg tactcttggc gtgatgcgcg aagacaagcg tctgcgcatt gctgaagaaa 4080 ccatggatat ctatgcgcca ctcgctggcc gcatgggtat gcaggacacg cgtgaagagc 4140 tc 9142 <210> 12 <211> 198 <212> DNA
<213> Stealth virus <400> 12 gagctcgtgg atgcgctgtt cgcgaaggcc gacgcggtcg tgcactatgc ggcggagtct 60 cacaacgaca actccctgca cgaccctcgg ccgttcctcg acacgaatat catcggcacc 120 tacacgctgc tcgaggcggc acgtcgacac gaacgacgtt tccaccacat ctcgaccgac 180 gaggtctacg gcgacctc 198 <210> 13 <211> 4626 <212> DNA
<213> Stealth virus <400> 13 gagctcttca cgaaaatcat caacatcgtc gcgctcgatg gcatcgagga cctcatagac 60 ttcctcgagt gtataaggcg cgattgatct ggaggtctgt tctacgtccc agggacagcc 120 cgtttcgggg tcacgaaggg caaccatgat ttcgagaaga cggttgatat tgcgggaggg 180 ttccatcttc gctccattaa aattgatgtc gcattcttga ggcagtctgc aagaatcgga 290 gggtttgggt tgcagttcgc tacggttttt gcatagtcag ccaacaaacg ctctcgggat 300 cgcacattgg ggctgtatgt tcaacaagca ggtatttaaa gcatgacgat tcttgtaact 360 ggtggcgccg gatatatcgg ttctcataca tgtgtacagc tgatcgaggc cggccatgat 420 gtggtggtgg tcgataattt cgataacagt aatccggaag ctctccatcg cgtggaaaaa 480 atcactggtc gcgcacctat tcgcgaaccg ggcgatattc gcgaccgtac tttgctggaa 540 cagatcatca cgcgtcataa atgcacggct gtcatccatt ttgccggttt gaaagcagtg 600 ggtgagtcga gtgaaaagcc gttgcattat tatgattgta atgtgcttgg cacgctgcgt 660 ttgttgcagg ctatggaagc cacaggcgtc aagacacttg tcttcagctc gtctgcgacg 720 gtttatggcg atccagaaaa attgccgatt accgaagatc agccgctttc cgcgaccaat 780 ccatatgggc gcacgaagct tattatcgaa gatatgctgc gcgatcttta taacagcgat 890 aacagctgga agatcgcgat cctgcgttat ttcaatccgg tcggcgcgca tgaaagcggc 900 ctgatcggcg aagatcccaa gggtattcca aacaatctga tgccgatcat cgcacaagtg 960 gcaaccggcc gccgcgaaaa gctcaacatc tggggtaatg attataatac gccggatggc 1020 acgggggttc gtgactatat ccatgtcgtt gatcttgccg ccggacatct caaggcgctc 1080 aagaaacttg atgaaccaaa gtgcttttct gtcaatctgg ggacagggca gggctacagc 1140 gttcttgatg tagtaaaagc cttcgaacac gtttcaaatc gtgaaattaa atatgagctt 1200 tcgccacgcc gtctgggcga tgtggccgag tgttatgccg accctgcttt tgcacgtgat 1260 ttccttggct ggactgccga gaaaaatctt caggaaatgt gcaaggacat ctggaactgg 1320 cagtcgaaaa atccaaatgg atatgagatg gattgagggt tgaaaggccc ttatgcagct 1380 cattttcccg gaaaagtgat ccgattggcg gctaactccg tcctttagtg ttgtgccgat 1440 ttctgatcgg cttattacaa actagtggat tgaatttgac ggttgaatcc cgactgacat 1500 acatgctgtt tcaaacgtca aattcgaaaa atccactaga ttcataaact tgctagtggt 1560 catcttgatt ccgacatttg tccgacgcca gtatccgagg gatgcaaata tcggaatcag 1620 accgctaggg atcacaacta gctcggaacg ttctcggagg catgtgtgtg tgttcttggg 1680 tagcgttcaa gtatgaagtg ctgaaggact gacgagaaat gcgttttctg cccgataagt 1740 tcacctgcat gttgattgcg accattctgc ttgcatcatt tcttcctgtg cagggtgatt 1800 ttgctgaatg gttcggaatt gcaacaaaga tcgcagtcgg tcttttgttc ttcctgcacg 1860 gcgcgcgttt gtcgcgtgag gcagttgtgg ctggcgtcac tcactggcga ctgcatctgg 1920 cggtcgtctg ctcaacattc gtcctgtttc caattttggg actgaccgca ggctggacta 1980 ttccggggct tgcgcaatcg ccgttttatc tcggtatcct ttatctctgc gttcttcctt 2040 caaccgtaca atcttcaatc gcctttacct ctatggctgg cggcaatgtt tctgcggcca 2100 tcgtttctgc atcggcatcg aatattttcg gcatgttcct gacgccgttg cttgtcggac 2160 tgctgtttgc ggttaaaggc ggcggcggga tttcagtcga tgcgctggaa gcgattttgc 2220 tgcaattgct tgcaccattt gttctggggc aaatcttgca gccatggatt ggtaatttca 2280 tgcgtcgtca cagcaaatcg cttggctttg tcgaccgtgg ttcgatcctg atggttgtct 2340 atctcgcatt cagcgaggct atcgttgaag gcctgtggca caccgtttcc tggaacgatc 2400 tttgcgtcat gatcggtgta aatatcctgc ttctggtgat cgtcatgctg gccacatggt 2960 atggaagcaa gtggttcggc tttaatcacg ctgaccgcat caccattatg ttttgcggtt 2520 cgaagaaaag cctcgccagc ggcgcgccga tggccagtgc gatctttgcg ggcgcgaatg 2580 tcggtagtgt cgtgctgccg ctcatgctgt ttcaccaaat tcagctgatg gcttgcgcag 2690 tgattgcgcg caaacttgcc gatcataagc ctgcttccag tacggcaact gcggcggctg 2700 aatagaactg gttcttgctg tcatcttcat atgagggtag gagggcaggc gagtagttcg 2760 cctcgccctt tccatctatg gaacaggcgc cgtaacccgt ataatagctc tctactggcc 2820 ttttcagttc gctgacggct caacaaaagg caacgcagat gtccaagcag aacggcaaat 2880 cccataacat ggattctctt gaccaagagg cgcttgctga ggcttacaac catgcgcttg 2990 ccttggaaaa ggctggcgat ctggatgctg ctgctgaggc ctataaagca gttctcgaaa 3000 ttgatcccga agaccacggt ggcgctgccg tacgtctcgc aagcatgggt cgaggaactg 3060 tgccgccgaa agcaccggac gcttatgttg caacgctgtt tgatcagcat gccgagatgt 3120 tcgatacaat tctcgttgat cagcttggtt acgacgtgcc actgcaattg cgtgaaatgc 3180 ttctggaact ggatgaagag tttcaggccg agcgcatgct ggatcttggc tgcggtacag 3290 ggctttctgc cgatgcgctg gacgacatgg ccgatcacaa gaccggcgtc gacatatctg 3300 aaaacatgat cgaagtggct tatgaaaaag gcgattacga tgcgcttttt gtcggcgaag 3360 cagttcgttt tcttgagacc acagaggaag acgcttggga cctgatcgtc gcaacagacg 3920 tgttgcctta tatgggcgag cttgccgctt tttctcgggc gttgcggagc atctgcggac 3980 tggaggctat ttcgggttct ccagtgaaac gcagtcagat gagcgtttcg ctggccgtga 3540 tttcatggtt ggcgattttc aacgttttgc acatgcgcag tcctatgtac gttcgctgct 3600 ctcagaacac ggtatggact gtattcgttg cacggatatc actgttcgaa gtgagcaagg 3660 atcgccagtt ccaggacatc tctacatagc tcagcgccgc taacgtttat tgggtcttgt 3720 gtgcgaactt agatcatctt gttccataat ctatcttatg tgattacgac atgtaggggc 3780 tatttagtaa tgcgacagtt gggccagtta gagatgcgac gtgtcgcctc ttgaggtgct 3890 ggtcaatgtc aacgttggag gcaaggatga cgatcttcag tctggttgag accatgagcg 3900 gttggagtcg tcatgccctg tttgatcacc atgtcgcaga aagaattgca tcgcctcgaa 3960 gtcgtccaga agatccgtga tctacgcctg agcgttgtcc aggcggctga gctgcttggc 4020 ctcagtcgaa gtcaggttca caggctgctg caagcctatg accgggatgg tccagctggc 9080 ctcgtttcca agaagcgatc gcgtccgagc aaccggcgtc acagcgagga tttccgtaat 9190 acggcgctgg acctgatccg cgaacgctat ctggatttcg gtccgacgct ggcgcgcgag 4200 aagctgatcg aactgcaccg gatctctgtt gccaaggaga cgctgcggca atggatgacc 4260 gaggccggca tctggatctc gcgccgggag cgcaagaaac gggttttcca gccacgcggc 9320 cggcgcgact gctttggcga actggtgcag atcgacggct cgcatcactg gtggttcgag 4380 aaccgcggcc ccaaatgcgc cctgctcgtc tacatcgatg acgccaccgg caagctcttg 9440 catcttcgct ttgccggatc ggaaaatacg ttcgactatc tgcatgcgac gaaggcttat 4500 ctgcagcaat ggggcaagcc gctggctttc tacagcgaca agcacggcgt tttccgctcg 9560 ctccatgcgt cgaagaaaga ccggacgagc ggtctgacgc agttcggccg ggcgctttac 4620 gagctc 4626 <210> 14 <211> 9199 <212> DNA
<213> Stealth W rus <400> 14 gbbbcgaatt ctggtatgag acggacggca cgccgttcaa tcccggaaat tattacaatg 60 tcggcggcaa ttccaaattc tatggcgcag tgctggtgcg ctatcggcgc gaagattttg 120 aggagcttgc gcatcttgaa ggcgtgtctc cggcatggcc ttttggctat gatgaacttg 180 agccctggta ttgcaaggcg gaagcgcttt ttcaggtgcg cggcgagctt ggcgatgacc 240 caaccgagcc gtatcattca aagccttatt cttatcctgc aatcaatgat gaacatccga 300 ttgccgatgt acgtgagcgg ttgaaaaagg cagggctgca tccggcttcc ttgccactgg 360 gtgttgatat cgagcgctgg ctggcaaagg ccaaaacgcc gtgggatgcg catcccaaca 420 gcaatgacgg caagatggat gcggaaacct gtccgttagc actcgcactc aaacatccaa 480 atgtccggct tgaaacatcc gcgcgggtaa cgaagctgga agccgggccc gacggaaaga 540 ccatcacggc agttcattat gtgaagaacg gcgaggcgct ggtcctgcgt cccaaactgg 600 tcattctatc tgccggtgcc gtgcaatcgg cggcacttct gctgcgttca ggactggcga 660 acggttcgga tcaggtcggt cgcaatttca tgaaccacaa tgccagtgcg gtgatcgggt 720 ttgatccgcg ctatcgcaat gacagcgttt accaaaaaac gtttggcttc aatgattatt ?80 atctctcgga tggggctggc gggccgcccc ttggcaatgt gcaattgctg gggagggttt 840 caggcgcgat cctgaaatcg aatatgcagc gagtgccgga atggcttttg aaccgcattg 900 ccggacacac cattgatttt tacgcgatga gtgaggacct gccatcgcca gaaagccgcg 960 tgagcgtgga tggtgatcgc atcattctgc attgggtgcg ttccaactgg aaagcacatc 1020 tgatgctggt tgataagctc aaatccgcgc tcaggcaggc gggctttcca attgtgctgt 1080 cgcgggcctt tgaccggcgt acaccatcgc atcagtgcgg cacggtgcgt attggcaatg 1190 attgcgcgac ggcgccactt gatccctggt gccgtgctta tgaccaccct aatttctatg 1200 tggtcgatgc gtcgtttctg ccgacctcgg ctgcggttaa tccggcgcta accattgcgg 1260 cgcaggctct gcgcgtatcc gaccacattc aaagcgaggt gctggcatga accgtcaaag 130 acctgtggca ctggtaaccg gcggctgtcg cggcatcggg cttgggatag cgcgtgcgct 1380 tgccgccaag ggttttgatc tcgccattac cgatcgcgaa agcgacgacg ctgtcattcg 1440 tgaactacgg gaacttggcg gaaaagtggc tttctttgaa agcgatcttg ccgcggttga 1500 tacacatgag gcggctgtat cagctgtcgt gagcgaactc ggtggcattg attgtctggt 1560 caacaatgca ggcatgggct caattgagcg aggcgatttc cttgggctga agcccgaaaa 1620 cttcgacacg atcatggatg tgaatctgcg cggtacggtg tttttcaccc aggccgtggt 1680 gaaggccatg gtggcggtga acgaggtgcg ttttccacgc agcattataa caatcagctc 1740 cgtttcgtcg gtgatgacct cgcccgagcg gcttgattac tgcatcagca aagcagggct 1800 gacggcattc acgcaaggac tggcattgcg tttggctgaa gcgaggatcg gcgtgttcga 1860 ggtccgtccc ggcatcatcc gcaccgatat gacggcgaaa gttgctgagc gttatgacgg 1920 actgattgaa gccggtctgg tgccgatgaa gcgctgggga gaggcgggcg atgtcggcgc 1980 gattgtggcc ggacttgccg gtggcgattt catttttgcg acgggctcgg cgatcaatgc 2040 cgatggcggc ctgtcgattg caaaattata agggtaaggc gatggattac gattatatca 2100 tcgtgggtgg tgggcctgcc ggctgcgttc tcgccaatcg tctgagcgaa gatgcttcgg 2160 taaaagtgct gttgctggaa gctggtggta gcgactggaa tccgctgttt cacatgccag 2220 ccgggtttgc caagatgacc aagggtgtgg cgagctgggg ctgggaaacc gttccgcaga 2280 aaca.cctcaa aaatcgggtg ttgcgctata cgcaggcaaa agtcatcggc ggcggctcca 2340 gcatcaatgc gcagatttat acgcgcggga atgcagccga ttatgatctt tgggccggcg 2900 aagacggctg taccggctgg gactaccgcc atgtgctgcc ctattttaaa cgcgccgaag 2460 acaatcagcg tttcaacgat gatttccatt cctatggcgg gccgcttggt gtttcgatgc 2520 catctgcgcc actgccgatc tgcgacgcct atatccgagc gggccaggaa ctcggcattc 2580 cgtttaatgc ggatttcaac ggtcgcgaac aggcaggcgt cggcttttat cagctcaccc 2640 aacgcaaccg ccgccgctcg tctgcatcgc ttgcttatct gtccacgatc aagggtcgca 2700 agaacctgac gatccgcatg aatgcaccgg tgcgcagtat cgaaatggag aagacgcgcg 2760 tcaacggcgt aacgctgatg agcggggaga ctttgcgcgc aagccgcgag gtgattgtat 2820 cgtccggcgc gattggttcg ccgaaacttc tgcttcaatc cggcatcggc tccgcggatc 2880 atctgaaaaa ggtcggtgtc gcggtcaagc atgatctgcc gggtgtgggc gagaacatgc 2940 aggaccatct cgacctgttt gttattgccg aatgcacagg cgatcacacc tatgatggcg 3000 tggcaaagtt gcatcggacg ctgggcgcgg gcctgcaata tatctttctg cgctctggtc 3060 cggtggcgtc cagcctcttt gaaaccggcg gcttctggta tgctgatccg gatgcccgct 3120 caccggatac ccagtttcat ctggggcttg gttcgggcat cgaggcaggt gttgagaagc 3180 tcaaaaatgc cggtgtaacg ctcaactccg cctatctgca tccgcgttcg cgtggaaccg 3240 tgcggctggc atccagcgat ccggcagctg cacctctgat cgatcctaat tactggagcg 3300 atccgcatga tcgcaagatg tcgcttgaag gtctgaagat cgcgcgcgaa atcatgagcc 3360 aggatgcatt gaaaccttac gtgatggccg agcgtctgcc ggggccaaag gtcgtcagtg 3420 acgatgatct gttcgattat gcttgcgcca atgccaagac cgatcaccat ccggtcggca 3980 cctgcaggat ggggacggat gcgatggctg ttgtcgatct tgatttgaaa gtgcgcggtc 3540 ttgaaggtct gcgggtttgc gacagctcga tcatgccgcg cgttccgtcg tgcaacacca 3600 atgcgccgac catcatggtc ggcgaaaagg gggcggatat tattcgcggc ttcgatccgc 3660 tgccgccggt cgtgttttca tgggagaaaa acgagcagaa gcggcgtgca aggatttagt 3720 cagccttggt ttcatcaaat ggttcgaaac gcagatagcc agcaatgccg gaacctttgt 3780 agttgggatt gtcggatggg tggttcacgc cgtcattgac gggaataacc ttgaagtcga 3840 agggagaaac gccttcgagg caggccgcat tcacgccgaa ctggtgcggg ctggagcggc 3900 gctggtggaa ggtgtaaatc ccgcatttcg agcagaagaa gtgcttcgcg gcacccgtat 3960 taaacgtgta gagcgtcagc gcatcttcgc cttcaagaat ttccagtcca tccagatcgg 4020 cggagacggc aactgcaccg cgcatccggc aataagagca ggtgcaacgg cgcgccgtgt 4080 taaggccatc ggaaagtttg acgcgaaagc gcactgttcc gcagtggcag gcaccgttgg 4140 ctactttgat atcggggttc atgctggtct cctctttcag gaaactgata tttccatttt 4200 cacagcttta ccattgcctg aagttgatta aattgccttt cgagatcctt tgggagggaa 4260 ttttatgagt gggtttgcga ttgtcaccgg tggaagcacc ggcattggac ggcatcttgt 4320 ttccgcattt gcggaagccg gatatgcggt tgctttcagc ttcagaggcg atgacgaggc 4380 WO 99/34019 PCTIUS98/27?44 tgcaaataca cttatggaag aagtcgaagc tgcgggcgga caggcgttgg ggatcgaatg 4440 cgatgtcggt tctggagttg aggtcgaaga gttcttcgat gaagtctgca gctggtatgg 9500 tgatgcaccg gacgtactcg tcaacaatgc cggtatccag acttgggcgc cgttgctgga 4560 gctttccgag gaaggctggg acgatgtgat ccgcaccaat atgaaaggct gctttctgaa 4620 cacgaaagcc gctgccaaga ggatggttga cgtcggtaaa ggcggagcaa ttatcaatat 4680 cggttcgggc tgtaacaagc tcgcattccc gaagctcgtt tcctacacgg cgtccaaggg 4790 cgggattgag cagtttacca aagtgtctgc cgtggaactt gggccgcatg gtattcgcgt 4800 caattgcgtg gctcccggtg cgatttacaa tgagcgtacc gcccaggaac agcctgacta 4860 tgcagcaaca tggggccgga tcacgccact gcgacgggtt ggaaccgtgg aagacctttc 4920 cggtccggtg ctgtttctgg cgtctgatgc tgcgcttttt gtttcgggcc agactatctg 4980 ggtcgatggc ggcctgtttt cacaagccaa ctggccttat ggggcgtgag gaaaattaga 5040 tcggttccca cttttcggaa tgcgctttat cgtccgcgca tttgtgcgcc cgcgtctttc 5100 gagaagcgaa ggttccagaa ggtggccgtc agcgatatgc cggtcacaat aaagaaagcc 5160 atagagaaat ccgatgtcag cggtacgtcg cgctcatgcc aggccatgga cgtgtgaagc 5220 gcgagggcgc cgatacaaac gccgaaagaa agcatgagtt gctggaaggt tgaatagaag 5280 ctgttggccg agctcatctg cttttcatca accttgtcat aggcaaccgt attataggct 5340 gtgaactgaa acgacatcga aaagccggac atgaacagca cggcaaagat cagccaatgc 5900 ggccattcag ggctgaacaa accgcagatt gcgtaactgc atgacgagaa tatgccgttt 5460 acaaccagtg acgagcggaa gccgaaccgg cgaatgattt taggcgcaaa ggctttcatg 5520 gccatggaac caagtgcggt cgccaaaacc atattgcctg cggatacagc cgaaatgccg 5580 aaggctacct gcagcatcaa aggcaacagg aatgggtgcg cgccttgtgt gatgcgggtg 5640 atagaaccag cgaccatcga ggtgccgaag ctttcaatcc gcatcagtga aaaatcgagt 5700 agcggagccg ggtggcggcg cgagtgaatg acggtcgcaa tcgcaaacac aatgccaacc 5760 acaaagaact tggccgccaa agcgctggtg gtactggcac tttcaagtcc gaaaagcagc 5820 gcaccaagcg ctatgcccga caggatcaaa ccgataaagt caaaaggttc tttggtgtcg 5880 cttttatatt ctccgatata gaatgacaca aagatcatgc ccagaatgcc aatcggcaca 5990 ttgatgtaga agatccagcg ccagtcgagc caggtcacga acaggccccc aatgggcggt 6000 ccgaggattg ggcccataag cgcaggcacc agcatccacg acattgctga gatgaggtcc 6060 ttgcgctcga cagaacggat tagcaccaaa cgtccgactg gcagcatcat ggcgccgcca 6120 ccgccttgca acaggcgggc aaagaccaga aagggaaggt tcggcgcctg tgcgcagagg 6180 atagagccag cgatgaaaat acttatcgcg aagcggaaca cggttcgggt tccgaagcga 6240 tcagcgatct ttccgcttgc cggaatgaaa atggcgaggc tcagaagata tgatgtgagc 6300 gcgacactca tcgagggtgc ggcgacatcg aaatctttgg ccatggtcgg caaagcagtt 6360 gccaggatcg tagcatcgag ctgttccatc agcatagcac tcgcgacgat gagggcgatg 6420 atccggaaat tgcttttcgc ttccagtgac gcgttttgtt cactggtcga cgtttcagtt 6980 tcctggatga tagtcatggc tgcttcagct ttgcaaacgc gccgacctgt ctttcaaaac 6590 ggccagccta aagggtcgat catctgtgac gatctttttg gaatcaatct tcggtctggg 6600 gaatgtgtca ggaacggtta caaactcact cagaggatac gcgcccagtt gttggccaaa 6660 acgtcggaga gatgagaaag ctcgccacaa gaccgcgagc gggtatagca caaatggctg 670 gaaatcacag gacttcaaga taatttgagc gagatgggat cggccgttgc tgaggggtga 6780 atggtgatcc cgactggatt cgaaccagtg gcctcaagat taggaatctt gcgctctatc 6840 ctactgagct acgggaccag tcatcaaaaa cgcccggata taccggagca ttttccgaca 6900 catactgttt ttcatggctt tcgccaaccc cgcaaaaagc ggggcaggcg catttctttg 6960 catatcgaaa agcgtcaggc agcgagagcg gtttcaacca ctgacacgaa atagctaacg 7020 ccatatggaa tggcttcgtc gttgaaatca taggcagggt gatgcaggcc cggtgtgtcg 7080 ccattgccaa ggaagatata tgcgccggga cgcgcttcca gcatgtagga gaagtcttcc 7140 gcagccatca ttggagccac atcagttttc accttgcctt cgcctgccac attctttgca 7200 acgcgggcag caaagtcggt ctggtcgtca tgattatacg tgactggata gttgttcttg 7260 tagcgcacgg tgatttccgc gccgctaacg gttgcgatgc ccgccgccgc ctcgcggatg 7320 cgacgttcgg cataggcgcg cgtttccttg ctcagtgtac gcacggtgcc tgagagtttc 7380 gccgtttccg ggatgacgtt ataggcttcg cccgcatgaa acttggtgat ggaaatgacg 7490 agtgaatcca gtggatcgat attgcgtgcg acaatgccct gaatggcaac atgcagctgc 7500 gaaccggcta ggattggatc aatcgtgcgg tgaggctgtg cggcatgacc gccgcgtccc 7560 ttgataagca ggtcgaactc gtcggttgcg gccatgatcg ggcccttgca catggcgaac 7620 tggccgaccg caaggctcgg caaattgtga acgccataga cttccgcaat gccaaagcgg 7680 tccatcacgc catcctgaac catggcgaga gcgcctgcgc cgccttcttc cgctggttgg 7740 aaaagcaaca cggctgaacc gcgaaaatta cgggtttcag ctaagtattg tgcagcacca 7800 agcagcatgg atgtgtggcc atcatgaccg caggagtgcg ctttgccagg attcttggag 7860 gcccattcga caccgctggt ctcggtgatc ggcagggcat ccatatcggc gcgtaggccg 7920 atggccggac catcgccatg gcgtcccttg atgaccgcaa cgacgcctga gcgcccaacc 7980 ccggtttcaa caagatcgca accgaatgat ttcaactttt cttcgacaaa gcgtgccgtt 8040 tcatgaacat cataaagaag ttcgggattc tgatgcagat gacgacgcca tgtggcgatc 8100 tccgcttgag tttcgacggc acgattgagc actggcattt cggaaatatc ctgcagattc 8160 tctttattca gaagaaacga gaatatgacg tttcggtgaa agcgggcaat ccctatttgc 8220 cttttccttg ccacatggca tagataagag cagtacaaat tctccttttt gactggtgta 8280 ttcgcaagcc gttacggctt ttcaaggtcg atacaacagg aagcggaacc gataacccgc 8340 aggaattgcg gctcttgttg attggaacta cgaaatgatt tcgaagtcgt tgaaaatctg 8400 gtttgcaact gcggcgattt ctagcctggc cttagctggt gctttatctc ctgctttggc 8460 aaatccatcg attgcggtgg atgttgcaag tggcaaggtc tactccgcgc aggatccttt 8520 ccagcgctgg tatccggctt cgctgaccaa gatgatgacg gcttatgtca ccttccgcgc 8580 gattgaagca gggcagctga cgctggaatc tcctgtgcgc atgacggtca acgcctcgaa 8690 aagagccacc gagcaagatg ggttatcgtc ccggmtcggt gatgacgctc gatactgcgc 8700 tcaagatcat gctggtgaaa tctgccaatg acgtggccgt trcggtcgcg gaagctgttg 8760 gcggtacgga atctgctttt gtgcagcgca tgaatgcgga agcacagcgc atcggcatga 8820 gtggttcgca ttttgccaat ccaaacggtc tgcatgatcc gaacaattat tcgacagcgc 8880 acgaccttgc cgtgcttggc gtgcagttgc gccgcgaatt ct*wgnnscs cvvyrkbr** 8940 *kbnnnrmam hadataragr ahntwhnmar tndatnstat hbcdcmgtms nwrmansymb 9000 arahbcwhnm artnwhnmar tnhddtbcbw hnmartnnrm awhnmartnm crstwrdrdh 9060 ccdbbcttdg danbbddaa* rtntrywsta bwrddcmnts mmarynrmat ndcmntsmma 9120 rynrmatnda thhdcmbtat hbcdcddmws tathbcdcda tnstathbcd cmcrstwrdd 9180 cmntmswrdd cwrddcmnt 9199 <210> 15 <211> 9181 <212> DNA
<213> Stealth virus <400> 15 gbbhnbbcga attcattcat cttcatgggg cagcagaaaa atgaacatca ggaccagctt 60 ccacattgac accatggctg tcaccatgct ctttttcaac gggctgttca accttaacat 120 ctttcgagac gtagtggccg atgactcaca acaaaaaagt tgtgattata tgaaacaaca 180 acactttttt cgcacgatgg gtatagcctc tgtgtttctc agacccgtct ttagtcctat 290 catttacata tgtgtcagtc gtaaaatcat acagggtatc tgcaaattgt ttataaaagt 300 accaaaccat accataagct cggaacgtgt aaagcttatg tctccaaata gaatgaacga 360 cgatgcccca gagcttccgc ccagggaata tgaatccgcg ttctaaatta ttgcgcgttg 420 atagcgcaac gacacaacca gccgatatat gtttgagacc ggtcacaaac cccgacattg 480 caaatcgaca ttgttcgatt tgcgaacaga ctttttacaa acatgaacaa ctcctcctgt 590 aaccttctgc aagtgtttaa gatcgacgac gcatctcgcg atgtcagcgt cggtttctat 600 agcatcgcca tatgcgtcgg actcatagca aacatactga tattactggk cctaatcaaa 660 aggcgaaaac ttacctttgc cagcgacgtc tactttctga atgctaccat aggcgacatc 720 gttactactg scacgctacc cgatatggat gtattatgag ctcaactaca gccaattcaa 780 tcgagaagca tgtatcagtt tctccatcag cttctacacc cccctgttcg ttcaagcctg 840 gctcatgatc tccatcgcca tggaacgata ctccaatctg atatggatgg cacccattaa 900 aagaaaagta gccgtacaga attcaatcgt cgaggaccag tctgaactgt gatcgacccg 960 cgcgccaagc ttgccgctaa aggcggttgt gtaagcttcg ttggccgacg gcgcttttgc 1020 atcatattga ttgcgtcctc ggctcagaag accatcggca taaatcttgc cccagtcaaa 1080 atccttcgac agcgcgaagt tgaacgatcc ctgcaggaaa ccatcgcgat caggctcata 1140 accaaaagct tcgggagtcg tgaaattata gccctgcgtg ccggtcactg ccgcaccaaa 1200 ggcataatcg ataccatctt tgctgcgccc ttgcagagag ccggatacat aaccgcccca 1260 tgggtgcgtt acacctgttg tcacgcttcc gcagaaagag cgctcgccac acgctccgcc 1320 ctgcttggtg ataatgttga tgacgccgcc catcgcatcg gcaccgtatt gcgaggaatg 1380 cgcgcctttg gcgatctcga tacgatcaat tgagctcaac ggaatattgg aaagcgcagt 1440 cgccccggtg gtcgccgaag ctgttcgcac gccattcacc agaacgactg tctgtttcga 1500 tgacatgccc cgaatataga gattggaaga cgatccctgt ccgccatttg cggtgatcga 1560 aatgcccgga taatattgca gcagcgattg gagatccggt gaagcagagc gctcaatctc 1620 ggccttatca atcaccgtga cggaagacgt tgaacgctgc aacgatgtcg cgcggcgcag 1680 cggcgttaca acaatcatgt caagcacgac gccatcctgt gcatttaagt ttgtctgtgc 1740 gatagcatcc aacggcaccg ccaccagaat ggtcgatgcg agatatgcag ataattggag 1800 aatatgcatt aatttctact tcctgcgcgc aagctttgct tcaccgcagg tgtcagaaat 1860 cagggcgcaa gctccctgtc tttgtcccac ggcaacattt cacaatgtca ccgctacgga 1920 cggccgcgac tgaacacccc tcgtgtcagc catgggtgac tggatacggc aggtctcctg 1980 acttccgggt cttcatcggt cctccgcctt cccgaacacg aatgctcagt ggctataatc 2040 gtaagatacg atcataggag gatgactctc cggttacagt tgcgggggca gtctcggcat 2100 cagcaattta atgcttcacc gtgttccctt ttcatccacc ctctcgggca gaaccgtttc 2160 ctgaagcgag cgatagcaag gggaaggaag attatcaact gcaacaatgt gccccatctg 2220 aatcacattc agaacgaagt gattcagatt gttgaattgc aaaggttttc ctatctcaag 2280 aaatcgcgga agcgacgcag cgcaaagaag aaaagtacac tgccwattac aatcattgcc 2340 agcaattgcg gccacacaac actgagccct gcaccacgaa acagcaccga ttgtgccagc 2900 atcacaaaat gcgtattggg tgctgccaac ataatgttct ggatgatttc tggcatgctc 2460 tygcgcggtg ttgtgccacc cgatagcact tgcagcggca gcagaaccaa catcaacaaa 2520 aggccgaact gcggcatgga accggcaatc gttgcgagaa aaataccaag actggtggtc 2580 gcaaaaagct gcaatgcagy ccctgycaga aacagcgtca gtgaaccgtt gatcggcacc 2640 gccaagatac cctgaaccac cacgatcagc gaaaaggccg tagcgaccaa caccaccatc 2700 cccatcgacc ataccttgga gaccatgatc tcaagcggcg ttaccggcat caccaacaga 2760 tgctcgatgg tgccatgctc gcgctcacgg ataagggctg cacccgtcag aataattgag 2820 agcatcgtta ccgacgagat cacgttggtg atcgcgccaa accagccctt gttcaagtcc 2880 tgattgaacc tcgcacgcaa attgaggcca acgggcgttt gcgtgtcttc gcgatagcga 2940 ttgagaaact ctgtcacttc gcttgacaca atcgactgca catatccacc gcccgtaaag 3000 gcctggctca tgcgcgttgc atcgacgttc agctggattg ttggcgaacg tccagcgagc 3060 agatcacgct ggaagttcgg cggaatatcg agtgcgaatg tgtcaagacc agcatccatg 3120 cgcttatcca tctcgtgaga cgagataagt tttggcggca cgaaatatgg cggataaaac 3180 gcggtcgtga -tccgacccga aaccggcgac tgatcctcat cgacaatggc gataaccgca 3240 ttgttgaggt tttcaggcat agccttcacc gccgtataga ttgcgagcgt gaaggcatag 3300 acgatgagaa gcagaagcat cggatcacgc gctaatccgc gcagttcctt cacaccaagc 336C

tggaaaatat tggaaatccg catctcagcc cgcctgtttc ttgaggagaa caatgccgag 3920 aacagtaagc accggaatcg caatcagcag cggcaggaac gaccccgcca gatcggaaaa 3480 atcgagagcc tttgagaaag tcccgcgcga gatcgtcacg aaataagttg tcggataaat 3540 cttcccgata aaagcacccg ccccttgcag cgactgatac ggggtcgata atgcccgaat 3600 attgcacagc aggaatgagc gtcagcaatg ctgtgccgaa aatcgctgca atctggctat 3660 tgataaaggt cgatatcact aagcccatgc cagtcgtgat gatgacatag agcagcgctg 3720 ctgtggcata ggtcaggaag ctttccggta aatggcacgc ggaagatgaa gaccgcaaag 3780 gctgtcagca tcaaaaaatt gaggaaggcc agcgcgatat agggcaactg cttgccaagc 3840 agaaactcga atttcgtgac tggcgtcaca tagaaattga tgatcgaacc gagttccttc 3900 tcgcgcacca cgctcaacac cgcgagcatg gccgggatca tcaaaaggag aagcggaata 3960 actgctggaa ccatagccac aaggctctgc acgtccggat tatagcgata gcgaatttcg 4020 agattgaaat tgccaacggt agcagcgttt ccataaagct cgcgcgcctt ttgcgtcatc 4080 cagttggcgt gcatgccctg tacataacca cgtacggttt ctgcacgcgt cggcatcgca 9190 ccatcaatcc aggcccccac ctcaaccgga cgaccacgcg cgacattgct gccaaagttc 4200 ggcgggattt caatcgccag gctgatctcg ccttcacgca tccttcggtc aagttcgtca 4260 tagtcggtaa tgggagactt ttccgtgaaa tagcgcgaac cggcaagctg ctgggtataa 4320 tcccggctga tcgtggtgtc atcgcgatca agtaccgcaa atgtcaggtc ttcgacgtca 4380 agattaatac catagccgat gacgaacata agaatgacag taccaagaat ggctaatgtc 4440 gcacggatcg gatcgcgctt gagctccagc gcttcgcgcc tagaaaatgc gagcatccrc 4500 cgaggattag gcaaccagct tgatgaaggc tttggattct tcaccggctt cttttcgggt 4560 attggatcag atttttcctg attactcttc tgcggcgcag tctcgcctat cgcttcttcg 4620 agataggcaa taaaggcatc ttcaagcgtt gccgaactgc gactttctgt gatcgccttt 9680 ggcgtgtcac tgatcagcac cttacccgca tgcatcagcg aaatgcggtc gcaaagctcg 4740 gcttcattca tgaaatgggt cgagacaaag atcgtcacat tatccttgcg cgaaagatcg 4800 gcaagtatct gccaaaatgc atcacgcgca acgggatcaa cgcccgatgt cggctcatcg 4860 agaatgagaa tatcaggcga atgaattrag tgctaccagg ccaragmcag ggcgctgscg 4920 aatgccaasc ggcatagact ctggaagctc atccataacc ccagccaaat caaaatgttg 4980 cgcgagttcc ttgattctgc gctgggtgtc ttccgcattc attccaaaga gctttgcgtg 5090 cagctccagg ttctgatgta ctgtcaattc tgaataaagc gaaaaggctt gcgacatata 5100 accgacacga cggcgtatat cgatatcctt gggatcgacc tcgcgtccaa acaaccgcgc 5160 tgtgccttca ctcgctggca aaagtccggt cagcactttc atggtcgtag atttgccaca 5220 gccattagag ccgagaaagc cgaaaatctc accgcgcgga atgcggaagc tcacattatc 5280 gacagcggta aaattgccaa accgcacagt gacatgctca gcttcgatag cgatgccgct 5340 atctgcctca gcattgcgcg acgggcatca caaacctctt tgtgcccttc ccgtaactcc 5400 tccggcaaac aaagcaataa aggctgcatc gagattgggc gtctttgttt gttcaagcag 5460 ttcctgtggc gttccggtcg caagaattgc gccatcattc atcgccacaa gccaatcgaa 5520 gcgctcggcc tcttccatat aagccgttgc cacaatgacg ctcatgcccg gacgatcttt 5580 gcgaatatcg tcgatcagct cccagaactg acgtcgtgac aaaggatcga caccagttgt 5640 cggttcatca aggatcagca aatcgggatc gtggatcagc gaacagcaaa agactggttt 5700 tctgcttcat accgcctgaa agctttcccg ccggtcgatc cgcaaagggt gacatccccg 5760 ttcgagccaa aagatcggct atacggcgtt cgcgttcatg cttgtcatgg ccaaataagc 5820 gaccaaaaaa ctcgatattc tcgaacaccg aaagtgtcgg ataaaggttc ttgcccagcc 5880 cctgaggcat gtaagcgata cgcggaaaaa ccgactcacg atggcgcttg ttggagatat 5940 cgccacccag cacatcaatc tttccctgtt gcatggcgcg tgcaccagcg accagtgaaa 6000 gaaggctcga ttttgccgac accatcgggg ccgatcaggc cgaccatrca gcctgctgga 6060 acatcgagtg agatgctatg aagtgcagca gcagacccgt agggacagcc ctacaccttc 6120 agcgcagacg acaaagctac cgtcttccac accagccttt atcgaggccg cactcatttt 6180 acggtttccg cgaggttctt cggccattca gcattcgcat caagcttgac gtaagccatt 6240 cctggcaggc cagtttttac ctgctggatg tatttttgca gcaaatcctg tgggattttt 6300 gccttcacgc ggaacatgag cttctggcgc tcttcttccg tttcaaccga cttcggcgtg 6360 aactgcgcaa catcagcaac aaagctgatc gtcgccggga tcacatattg aggtgccgca 6420 tcgagcacta tgcgcgcatc tgccccaata gctacacgac cagcctgcgc agtcggcagg 6480 aagaacgtca tatagacatc gctgacatcg accagattaa gcacgcgacc accggctgac 6540 agcacctcgc ccggttgcgc aacgcgatat tgtacgcggc ccggctttgg cgaacgcaag 6600 gtggcatcgt tgatatccgt gtcgattgtc gcgatggctg cctttgcagc ctcaaccgcg 6660 gcttcagcat cgaccacctg cgccttggca gcactgatcg cggctgcggt tgccgcaagt 6720 tgggctttgg cggcaccaac agcagcttct gcaccttgag cggttgcgcg gtcatcatcg 6780 agcacctgct gggaaacagt gcgcgattcc gaaagctgct gtgaacgaac aagtcgtcgt 6840 tgggcagcat ccaattgcgc ttcgcgttgc gcgacggttg cttccgcagc agtttgttcg 6900 gcttcacgct gggcgacgag acttttagct gtatcaatgc ttatttcagc acggcgcagt 6960 tgtgcttctg cctgtttgcg ctgactttca agctgagccg tatccatccg ggcaagaatg 7020 gcattcgctt caacgaattg accttcatcg ggctaggatt tcgcggatgc gtcctgggct 7080 tttggtcgaa acgtcgatct caacagcttc aatacgtcca ttcccgcctg caataccatc 7140 cggcaaaccg ggatcgctca atgtcttcca ggcatagtag cctccgacgg ccaaagccac 7200 gaccacaccg gttacgatcc actgcttgcg attaaatccc atgccgaaat atcctctgcg 7260 tcatcatctt gcggacccgc acagctaaat tatgcggcaa atgattttat taaatcagac 7320 tgagttcagt attttcactg aggcgagatc gccttgatta aaatcaacta tactcaaatg 7380 catcgcagtt tcatgcgata aataacaata aatataagaa agttcgcggg tgccgattta 7440 gtgagatgga gggcaatgct gacagcaccc gctgactgtc gacagtacaa cattgcaaaa 7500 gatcgcgctg gtgcgctcga cagatcccta aacaacttga gatttaattc ggaaagttta ?560 gccgggacgt cgctttaggt tgggcctcga cgtcccgggc tgtcagttct ggtggaacct 7620 gacaacgagc gatcattagc acccggtcat gaccgctttc tttgatctaa atcaattaga 7680 taataattat atgcaatcac acccactatt ttggtgagcg gcacttaccc cagctcttct 7740 ttagatagga cgatacgctt ttaagcttgg gatcagacaa aaagccctgc cgaaacagaa 7800 tactgccttt gacctctggg atcgcgtcat tgatatcgag ttggcgtttg atttcgtcca 7860 cgccattgcc ggcaccccat tccggctcag acttcgcaga agtacccgcg cgataaagcg 7920 ccatgccgat ataaagatcg gtctttgtgc ccttgacggt atccgcccac catttcacga 7980 tagggccata gggcacatct ttacgccctg acgaccaata gacctgcggc gcaatatagt 8040 cgatcaggcc gtctctcacc cagacgcgtg tatcggcaaa atcaccatca tagttggttt 8100 tgcccgcccg cgtcggcgaa ccgcgaggat catcgatctg attgcgccag acgccgccgg 8160 ggctgatacc aaagcggaca tgtggcttga tcgctttgat cttgtgcgaa atttcctgca 8220 ccagcgtata ggtattgtag cgccgccagt catgtttgct ggagaaccgc gtcccaaaac 8280 gtttgaatgt tttgtcgtct ttgagcggcg agccttgcgt ttcgtaatag aaatagtcat 8340 cgaactgtat gccatcgaca tcatatttct gaacgacttc ggccgtgata ttcgtcaccc 8400 actggcgcac atccggaata cccggatcaa gcacataacg atccgcagat atagccaccc 8460 agcctggatt ggttttatag acgctgggcg gagaatcgcc ggcagagttt ttcagttctt 8520 tccgcgttgc tggtcgcaca tccatcgaaa cgcgataagg attgagccat gcatgcagct 8580 cgatcccgcg cttatgcgct tccgcaattg caaagcgaag tggatcgaag cccggatctt 8690 ttccgagcgt acccgtgaga taagacgacc acggcagata ctccgattta tagaaagcat 8700 cggcagcagg agagacctga aaaatcatgg cattgatgcc atgctccgac gcctcatcaa 8760 acatccgcac cagctctttt ttctgacgct ttacccgttc ggaatcatct tcaatgagag 8820 tggaagcccg cgacggccaa tcgagattaa garcagttgc aacccagctt gcatgaaacg 8880 tatcgcaatc aagtggcatg gattacagaa ttcwhawha* ywvtsrnm*y wvtsrnmkhg 8990 *khg***dcb a***dcbanr mamhadatar agrahnth*w hnmartndat nstathbcdc 9000 ggmgtmsnwr mansymbara hbcwhnmart nwhnmartnh ddtbcbwhnm artnnrmawh 9060 nmartnmcrs twrddhccdb bcttdgdanb bdcdaa*rtn tryatabwrd dcmnthsmma 9120 rynrmatndc mntsmmaryn rmatnhcmbh hhhmcrstwr ddcmntmswr ddcwrddcmn 9180 t 9181 <210> 16 <211> 7312 <212> DNA
<213> Stealth virus <400> 16 g*bbmavbcg aattcgaaat tgacagactc gtcgctgtcg ctctcttcct tggcgtcgtt 60 aaagtaatta gagtttctat ccccggggtt ggcacccccc ttggatgtta agtaattggt 120 gatcttgtgc tgatcgtact tttccttggc gttgtggtcg tgttcgttga tttttcgtgc 180 ggacatccgc tcgtgcttgc gacccacggg ctcggggagc atctcgctgt ccattccaga 290 cacgtcatcg tgcaaagcgc ctgaatttgg gaccgctgct gccctctgct gcttgaaatt 300 tttatcgaag ctcaaatcgc cgcgctggaa cggctcctcc gtgaggaagt tgtccacgca 360 gaagagaccg ttgtggctgg acacgtgcaa caccgtatcg tgctccgtga cgatgcggac 420 cgtgcacggc agcttggtga ccgcgcaatt catcagggtc tgatacagat tcttgagttg 480 tacgtgcacg cgcatatttt taaccccatg aaaactgact cgagtgttag ccgtgaactc 540 cagctcgctg ccactgctga ggatgaattt tatagccgga ggggcagaat gtaccagaat 600 ctgaattgtg cccgtggggc agggagcctt tttgacactg cgtttaacgc gcgtgtgagg 660 cgagatccac ttaatgagct cgctcacgac gccatgatcc aaatcaacgt gcacggccga 720 actgtcactc tcacgtacca aatcttggct gtgcacgcag ggcgagctga actccatgtt 780 gaaatctggg gcgcacatgt gaattttagc ggacaggtca gagatatctt gcacgtaaaa 890 cttggttaag tccttgctag aggtcaggta cataaagtta cccagcatgg gcgtggaatt 900 gttaatggtt ttcggctgaa acgacttgtc ggtaatgtac agacaggagc tgttgaacgt 960 gattttagag acaaactggt tgcgtaccgt ctgcaggacc agagcggggg tgggcagaaa 1020 ggtcacagtg gtgttttcct ttaaagtacg aattaccgac cgcaactgct gaatggccga 1080 cttatacggc ttcagccgca gcgccagcgt gggaggctcg ggtaaacggg cttttctctc 1140 catgtctgcc acgctcctga gacccgcagc cagctcctag atgtgtcctc gtccggaacc 1200 aacagtcaaa taagcctaaa cgggttaaat aattgacttt tatagaggac ggacggtgcc 1260 gcaaaataac cacgctgaaa gtggaacgat tgcagcacac agcagggttt gatagcgttt 1320 aatacagctc tggtaatatc taggttagca cacaagtccc atctagggag cacagtactt 1380 atatactcca accttacagc gcaagtggta ccatttcaac atcctcttca tcagatcatc 1440 gggggtcata gagggctcgt aatagaaagg caacgtgaga cactggtcca catacatact 1500 catgttcaca ctggccattt ctacgtcgga atgcagttcc gcggcccgct gaaagacaca 1560 atcagagacc tgcgaggggc gagcgctctt ggatttgagc tcgtcctggt gctcgatcca 1620 agcgtaattc acgacgggga ctttcaagtg tctctgcatc acagtgggga aataacagtc 1680 ctcggtgggt ggactgatgg gcaaaacggt gttctcctcg acgattttgt cttttgcggc 1740 ccacaccgaa ggggttacac tccacagatg ggcaacgtcc tcgtcgggac cgatagccag 1800 aaactgcaca ttgcgcgacc cgtattgttg catctcagtc cggagggtct cccactgcgt 1860 cgttgggagc gacagccggg gctttcgata catttcaaaa ataaacttgc cctccttgta 1920 gatggtgcga tcaaaccact cgcagggtgg cagaccggac ttacacaggt ccacgctggt 1980 gcgcagcgcg gcatagtaca tgttttcaaa aaccctctca attaagtccc aggaggcgaa 2040 ataggtaaac cccagacgca ttaacaccgt atgcagaccc actacaccga ggtttaaacc 2100 ccgcatttta gacaaggccg actctacagg ccagtctcca gccgtaatca tggcatcgag 2160 acgcccgttt gcccacacca ccgcctcctt caccagttcg cgaagcacct gtaggtcaaa 220 ataacgcttt gtgtttccca aaatcacatc ggacctggga agcgcgtcct tgtcactacg 2280 ggtgaacaaa cagcgtgcca gattgattga cagtcgctgt atggggatat cggcatccac 2340 i8 aaagtgacag gacgccatat ctggactcaa acatggcggc aggggaatct ggcccattaa 2400 cacagaatat ttcaccacgt tatgcacaaa cactatagca cacttcccct tcagggcaca 2460 gaacagcatg tttcgtaaga agtcactgga tttcacggtg actttggccg aagactgctc 2520 atagcgcgcg tactctctgt caaatgtcgt ttcgtttccg tgctcagaca gtttcctaga 2580 gatacaacgc ccgaataggg agtagttatc atcgtgggcg cggtaacgct tcatgagtat 2640 tcccggaacg ttaaaagcaa agtacactcc acatatggag gtctctttca ggataaagtt 2700 gagaactcga atggctgcca cgtcccacag gtccacaaaa attcgcacga taggcttgtg 2760 tacctctctt tcgcggatca tgtcacagaa accgcctata cagcgaataa cgctaacggc 2820 ctccacgttc aatcgggtga cattaatgga caccgacacc ccacgagtga gattttcgta 2880 cagycatttg tgcaaggtga cccagtccac atcacgagaa aacatatcgg aagacatgag 2940 gtagtcatgc ttaggcatct ccacgaagcc aatgttggac atggcaaaag gcgttatgga 3000 cagctgtccg tctcgacatc gcctgaggac attttccaac acctcaccct cgtgcctaca 3060 atcaaggtgg aaacgataca cccgggaaca agggctgttc acgatggctg acgtgatacc 3120 catcgcgttt cggagaaaag cgccccctag tgattcatct tgcccataca tctggcgaca 3180 gatggtgtcc gacaacaaga tggcggaata aaaaccccaa cagccggcca gatcaagata 3240 gcgattggtg tcctccaaaa gtttaggcag ttcttccgaa tgccgcaaaa caaagtcgcg 3300 tagatgttca tcgcacatcg aagaagtgta cgacatagcg cttcgatttt ctctcaccca 3360 gttgattttg agataaaagc gacccataag aagatccgaa cggggaactt gtttaatcaa 3420 accgggcccg aatcttatca acatctgaaa gaggcgatac gcgcctctga tgcccgtctg 3980 gcgtgaaacc acatcgatct cccgccacgt gttggcgcga tcctccacct gtttgacggg 3590 gtccggtaca tcgcaaaagc gaaatttgcc ccatcgaccg tgacaatgac acttctttcc 3600 catcagcagt tgcacagtgt tcatccccgg catatgggcc gctaacgaac aagaagctcc 3660 cagcctgagc gttcccccct cgtctccagt agaccagcga gccgccgcaa caccgatcgt 3720 cggctgcggt tgactttttt cttcttcaga cgaaactgtg gtgtccatag cctccccatt 3780 ctcactcgaa gcctcggatt cctccataat tgttccgagc cctacgctac cgttcttgtc 3840 ggacgcgtga gccatagcgc ccgataatga ttaaacgaac tctgcgaact ctcccagttc 3900 cacgttgaaa tgatccaaac gcaccgtcga caatttaacc tcttggtgcg tcacgacaga 3960 ggtgtgaatg tcgtcgtaca aacaccaacc cagtttctga ataaccccgg tacataagga 4020 gatgtgtcgc ggcctcgtga tccgcttgtt cacaaaagta cagcgctccc gggtgaattt 9080 ttgtcgcact acgtccgtca aggtgtggcg attaccgata ctcgacgtgg ccacataaat 4190 tgccacctta gtttccaagc cctcgtggtc gtaaacaata attaaataca catattgcaa 9200 tctctcctga gtttcttcca aacacatgta catgtccttc ggtatcgata acgaaaaaat 4260 ctctgttttt aacgtgttgt atatgtagcc ccgtaaaacg caggttagta acgacgtgat 4320 gcccagcgac accgacttca cgcaaccaat ggtccgaaga cgatgatgta agagcttact 9380 gcccatgtcc aaccaggtca aggcggcctt ggccggccct gaagtataga tgccctccag 4440 ctggcacctg gcgcccaccg acacgttaga ggccttgatg gccagcacgt acaggctgat 9500 gtacaggtac cgcggcgact cggcgccagt ttccatacga aacatgagag atccggggtg 4560 cacctcaaat tccaccagac cttctggaac aaaaaaccgc gatgtgatgg cctggtgatc 9620 cgcctcgtac aggtaatgga ccgctagtgt atttacttcc ctcttcaact tggtcgccag 9680 cacgagttcg ttatcttcat cgttcggatc cctcggtcgc ttggcgacat cgcgcacgtc 4790 catgatgagg aaacgcacgg tagactttca gtggcttttg agcgagctaa aacgacaatc 4800 aacggagact caggccgtgt taaatatcct aagccaaata gagatcggcg cactcaatgt 4860 tgagaccgtc aacgccacta aaatacaaca gttcctgcag cttttaccgc ggaaaggcta 4920 tcacttcacc ttcatccagc aaaatatcgt ctactacctg mttagtcaca ccacattaca 9980 aaccgccagc gatcccctca tggcggctaa aaacttctac gaagagataa aaaaacacgc 5090 cgagagacac accgtcacca gtccctgcga gtatctcaac aaccaaacca ctctcacgca 5100 cttggaaaca ttcctaacca aagtgcaaga actgcaggct tcgttcagca ccaaccaatt 5160 cctagccgcc actctaccgg atcaaaagag caaaaaaaca tcacgggata tcagcgacaa 520 tggcacgcag tacctcatac gaagcgtgtt cacgcagatc gaagaagccg tagaaaacgt 5280 gcgaccgttc agtaactgtc gtttcatcgc agaamtgctg gacatgctgt atcacagcac 5390 gctgcaatgg tccagtggat taatgcagta tcacgcgttc gcggaagatg gtgacggcga 5400 cctagacaag atcctcaaga tgtattattt ttacaaatac tatcaagccg ttaacaacga 5960 cctcaacagt gagtttcaaa cgttcattac tagcgacaaa cggaatctca gcgctttcat 5520 tctctccgac gcggatggag accagcagat tggggcagaa cacattaaag agttgagttt 5580 taaggtgttt aacgccaatc taaatgaccg cgacacgact ggactcgcgt ttcccataat 5640 tatgaccacg ttatctgtct taaatcacat gtcggtggaa aatatgtttt accatccggg 5700 actagtgttc agacttgctc agtgacgaat ctgaactcag ctccagcgaa catacccgcc 5760 tcgacttagt agcacaaatg tgcacccata tgagcggcga atttttccgc aacaccacca 5820 aacccttaaa actgcgagac ctcatgtcgc gtatccaaaa attcacctct ataggactga 5880 accgagaaac ctcccgggcg tatgcccaga tggcacttct ccaacccagt cgaacggcac 5990 ccaagaaggg aacagaaatg tggtttgaga ttcgacagca actgctcgtc atgatttaca 6000 acacatatgt gtttttcatg tgcctttggg tgtacagccc aacgttcctg ttcatccata 6060 gacggaagat gattctggaa caacaaaaat ccacgctgat cggatccaga cacgaactgc 6120 agttcatctg ggataatgta acacataata tcaaccacga ttttaatgtg atgtttaccg 6180 aagatgagtt taacgtgtgc accaaaggag ccacacagct ggaaaaagaa tacctttacc 6240 gcgacttgct gaacaaatgg ggtgacatcc tgtttgtgat gaaaaccaag ttaaaacctg 6300 acgcggaatc acccactctg gacaatgtaa ccaccgccga tgttattaaa cgttgcgcta 6360 tgatcaatct gtctgaaacc gatgtgccct acgaatcgtt actacccctg actcaccatc 6920 ccagttttct cgacacgttt gtcaacttag ttattgttcc ggagttttca caaatcctca 6980 acatccccta cacccaattt ttcaccgtag ggtctcctcg tctcctaaaa ctcattcacg 6590 cgtgccgtct gctagtgccc gatcagataa ccttatataa caaactggtg tccctctaca 6600 acctaaccac ctttgtgtct gagattgacg taggtgtgtt ccgcacagtg tacaccctga 6660 ctttggaaat cgccgcgata ctggagagcc tctgcggcga acctgtatct ccagaattag 6720 atctgctagt agagctaatg gctcaatcgc tctcacacaa tctagaaact acagtcaacc 6780 cactaatcga agaagtaatt caaaacaaca gtgcaagtat tgccaaatat ctagaccaca 6840 ctcatctgtg ttattgtttc gcacaaacca caggacagat gtccccagat atggcaaacg 6900 tggaaatcac cctagagtcc aaggtgatcg ctaatatacc catgactcag tttctgcaac 6960 tcactaaaac tctcattgat aaagatcaaa aactaatcga taatttctct agaattc*vn 7020 g**ywvtsrn mkhg****nr mamhadatar agrahnt*** **whnmartn datnstathb 7080 cdcmbgtmsn wrmansymba rahbcwhnma rtnwhnmart nhddtbcbwh nmartnnrma 7140 whnmartnmc rstwrdmmdh ccdbbcttdg danbbcdaa* bcdghkrtnt rywvvmtabw 7200 rddcmntsmm arynrmatnd cmntsmmary nrmatndath hadcmbtath bcdcddmwst 7260 athbcdcdat nstathbcdc wnhhmcrstw rddcmntmsw rddcwrddcm nt 7312 <210> 17 <211> 2103 <212> DNA
<213> Stealth virus <400> 17 *gbbsmbcga attcaacatg gataggattt tctgtgtaaa gacctgttga aatttttcca 60 ttttttaaga aaagtaattt cttcatcata tcttcagctt tgtattcatg agctacagcg 120 cctaaaatac cattaccata tcagaagtct tggaatctta aaaatgcacg accttgtttt 180 actaatttta gtaatgtatc attttcaggt ttagctaagt cttttttaac atctgctaaa 290 gattttgttg aagcaactat aacaccttca gtgttgtgtc taataccaaa aagtttttca 300 gctggtaatt gagtaatttt ttcaataccg actactgaac caaatgatct aagttgtttc 3E0 ttttcttctt cagttgcttt aactttttta gcaatacgat ctaataatcc tggtgaaaat 420 tgatctaaat cagcaactgc attagatgca actaaagttg taattctatc atgtggtgca 480 taaaaaatat ctggcacaat tttttcatct gttgcccctg taggcatttc taaagcacct 540 caaacatctt tagctattgt tttaatttca tagccatttt ggcctgattt tgttttctta 600 aacaattcaa ttgctttgtc atagaatttt tgttgaacgc catcaactgc aattaaaatt 660 gtttctgctt tcagtagtac cacaactaat tgtagctaat gctgtcactg gagctgctaa 720 ggttgcaaag ccaattgcta tttttttaaa agttttctta aaattactca taatttctcc 780 ttgttagcta actattcaaa aacgattaga tttttttcat aagcaactat tgaaaagata 840 attgctagtg gactaaaaaa agttaagaca aatattgttg caataattcc gcttcatttg 900 taaaattcgg ttttatccaa aatatagtaa acatgaatgc aaacgaatat tgcaaatata 960 taagaaagta atgcagctga aaataaaatt ctataagtat aactttttat ttcgctaact 1020 atgttttcta aatatttgcc ttcaaaagtt catttatttt tgcctagtaa atacaaaatt 1080 aatatttcta aaatcaaaat aatgatttga gtaaaaacta ataacatgta ttcaagaatt 1190 ttaggtaatg atcttctttc atttggtcat ttgcctaaaa aaagtcatct cattctagtt 1200 ttaaatgaaa cttttgtact ttttttgttt tctaatctcc tgtttttttg cataattaac 1260 taaataaatt atattttaaa attaaaatat atgccttgtc agtgtgcaat tcttgattaa 1320 atataggaac attacccttg accactcaag ataataaaaa attcaaaaaa caacaaattt 1380 tagtgtaaaa aatttctttt tgctgttttt tgtgcatttt atatattctt attcttaatc 1440 taacttaatc taattgtgga aattttctca tatatgagat tttaattttt aataagttaa 1500 ttcaactaac attaaaccag tattcccact aaaagttatt ttttcattgt ttatcgaaga 1560 attattagaa aaaataacat taattttagt tggagcattc ttaaagacta gatttcattc 1620 ttgaccataa gttgtatgat aataaattga attgactaaa actaaaaact ttttatcttt 1680 ttgctttgct ttaactaatt tatatccaag tcctttataa tcataaccgg gtttaaagag 1740 atcatctaaa ttagcataag tattttcttt ttcagcaaac atttttggat tttctttacg 1800 ataattaatt atttttttgg ctaaattaaa attagatttt ttattcttat gagcttgttc 1860 aatcgaattc vngnrmamha dataragrah ntwhnmartn datnstathb cdcmbgtmsn 1920 wrmansymba rah*bcwhnm artnwhnmar tnhddtbcbw hnmartnnrm awhnmartnm 1980 crstwrd*dh ccdbbcttdg danbbdaart ntrytabwrd dcmntsmmar ynrmatndcm 2040 ntsmmarynr matncmbdat natnatnnda tnatnmcrst wrddcmntms wrddcwrddc 2100 ~t 2103 <210> 18 <211> 3169 <212> DNA
<213> Stealth virus <900> 18 gbbsbcgaat tcaagggaac gaaagcacgc cctgctcgtt ctaagaaaat tcgcggctca 60 tggaggcttt gatgagaaac gtcgacagga aagatcgtct gatcctggcg ctcgcagcgc 120 tgctgcgtgc tgaacgcgaa acccgtggcg ctttggaagc agcactgcaa aacgaaagcg 180 tcaacctcga gacattacgc gcgatcctgt cggatccggt cccagtgatc acagaggacg 290 acatcgcatt tgccgagcat tttgcccgct caagacatct ccctccgttt cacctttcaa 300 acgagccgct cagcacagcg aagccaacgt cctgacgggt aagggtagcc gccaatcgct 360 ctccagcggg cggaaaccct gttgttgttt ggtcaaaaaa cgctaatctt ccgatatctc 420 gtgtttgagt ttgtttcaga atttcccatg cggagtgaat tgtgagcgat aacaaaattg 480 tgcagggtgg agccgcgcct ttggtctcca acacgcatgc ggcaagtccc accgcgcccg 540 ctgtttcccc ggactgccgc agcttgcttc ggacaatcga ctggccacaa aatccactcg 600 gcccgattga tagctggtcg cctgctctgc gttgcgcact ggatctcgcg cttccggccg 660 WO 99/34019 PC'T/US98l27744 acgctcagat tgtcattttc tggggacccc agttcatcgc gctttataat gacgcctatc 720 gtccgaccat cggtcacaaa catcctgcgg ccttcggtcg accggcccag gaaaactgga 780 cagaattgtg ggatgatctg aaaccattgc tcaaaactgt gctcgaaacc ggtcaaacca 840 tttccgcgca gaaccgccct tttcacatcg agcgcttcgg ctatccagag accgtttatt 900 ttgatatctc ctattcgccc atcggcgcct ccgaaaacgg agcctcgggc gttctctgca 960 tcgtcaatga aaccacatcg cgcgtggtcg cgcagcgcaa gctcactgaa aaccagcagc 1020 ggctggaatt gcttttctct caaactgacg cgggaatagc actgagcgag cgcaccggca 1080 ccctgatcaa ggtcaatccc cggctctgcg cgctctccgg tcatagcgag gaaacgctgc 1140 gcgctggcgg gctcgatgcc gtgctcgatc ccgcagatca agaagcttat caggtttcac 1200 ttagagcgct gttcaccacc ggggaaagct ttctgcaccg attcagcctg gtcggcgcca 1260 atggtcgccc aacccccgtt agctgcgctg caagcccggt gcgcgacgac accggtgcta 1320 tcacgcatgc ggtctggacc attatcgaca tcaccgaaca agtgcgtgca caggaactgg 1380 aaagtcagtt ggcggcaatc gtctcgtctt cccatgacgc aattctgagc accgatctcg 1440 aaatgcgcat tttgagctgg aaccacggcg cggaacgtct ttatggctac agcgctgccg 1500 aggccatcgg gcgcaaagtc accatgttgc tgccatccga cagaacgacc gaagaggtcg 1560 agatcatcga taagatctcg cgcggtctcg ctgtcgcacc gcatgaaaca gtgcggctgc 1620 acaagaatgg tacgcgactg gatgttcagt tgacggtatc gccggtccgg gatggcaatg 1680 gacgcatcat cggtgcgtcc aaaagcgccc atgatatcag cgaccgaaaa aagtccgaac 1740 aactgcagcg cgctattctg ggtgagatga aacatcgtat caagaatgtc ctggccaccg 1800 ttcaggcttt ggcacgccag acatttcgca atcccgctca taaaagcgcc tatcaaacct 1860 ttgaagcccg attgggcgcc atggcccgca cgcacgatct tctcaccgcc gatgtctggc 190 aggcgaccga actcagtaaa ctggtcgaag aggcgctgtt gccattcggt ctttccaatt 1980 ttgctatcaa aggcccggag atcgacgttt cttcacgtgc tgctatggcc ttttcgcttg 2040 gcctgcatga attggcgacc aatgcgtcga aatatggtgc gctttcagtg cagggcggct 2100 cagttcacgt cacctggtcg cacgatcaag cgttgcagca cctgaatttt gtctggcagg 2160 aaaaaggtgg tccccgtgtc ttggtgccca agagcaaggg tttcggtagc aaactcatcg 2220 agggcgtgct ggcgggagaa atcggtggta gcgttaaact gagttatcgt tccgacggtt 2280 tgcactgtca ggtcagcacc aagatcgcca atctcaccca acaaccgtaa actccaccgg 2340 cgacaacacc tcaggccccg cgctcacgca ttgatcggcc cattgccgcc cttgcgcatc 2900 gcctgacaaa gcgggatgcg tgctgatgtg ggtcgcagga ccatagggca cctcagcttc 2960 aaaccggcgc cgcgatattt cttcagaaaa agaattgagg gcatgaaaca aagccgccgc 2520 tcggcggttc ggtccatatg cgcatgcaac aagcatggcg caactacggg caattcaaca 2580 gaggagccgg aaaatggcca aagcaaagca acgcaatctt gatgatctgt tttatgacac 2640 gttgaaagat atctactatg ccgaacgcaa gattctgaaa gcgcttccaa aaatggcgcg 2700 ggcagcaagc gatgagaagc tgaaagcagc atttgaaacc caccgggaac agaccgaaac 2760 acatgtcgag cgcctgcagc aatgttttga attgctcgga aaacgcgcgc agggcaaaac 2820 ctgtgacgcc atcgaaggga tcatttctga aggcgaagag atcatggagg aattcctgca 2880 gcccggggga tccactagtt ctagagcggc cgccaccgcg gtggagctcv ng'nrmamha 2940 dataragrah ntwhnmartn datnstathb cdcmbgtmsn wrmansymba rahbcwhnma 3000 rtnwhnmart nhddtbcbwh nmartnnrma whnmartnmc rstwrdvvdh ccdbbcttdg 3060 danbbdaa~r tntrywnsta stabbcdcdd mwwrddcmnt datncatsmm arynrmatnc 3120 ddcmntsmma rynrmatncm bmcrstwrdd cmntmswrdd cwrddcmnt 3169 <210> 19 <211> 3878 <212> DNA
<213> Stealth virus <400> 19 gbbbbbbbby bcgaattcaa tttcactgag tctgcgttgg agacagcggg gaagtcgtta 60 cgccattcgt gcaggtcgga acttacccga caaggaattt cgctacctta ggaccgttat 120 agttacggcc gccgtttact ggggcttcaa ttcaatgctt gcacatctcc tcttaacctt 180 ccagcaccgg gcaggcgtca gaccctatac gtcgtcttgc gacttcgcag agccctgtgt 240 ttttggtaaa cagtcgctac cccctggtct gtgccacctc cacctagttg cctaaatgga 300 ggtcacgctt cttccgaagt tacgcgtgca ttttgccgag ttccttcaac gcagttctct 360 caagcgcctt ggtattctct accagtccac cagtgtcggt ttagggtacg gtctatatgc 420 aggagctatt tcctggaacc gcttcgctgc cagatcaatc caataagacc tgacaacaca 480 cgcaatccgt cactacctgc aggcccacga atattaacgt ggttcccatc gactacgcct 540 ttcggcctcg ccttaggggc cggctaaccc tgctcagatt aactttaagc aggaaccctt 600 ggactttcgg cgagggagtc tctcactccc tttatcgtta ctcatgtcag cattctcact 660 tccgatacct ccaggatgtc tcacgactgt cccttcacag gcttacggaa cgctccgcta 720 ccacgcacat acgtgcatcc acagcttcgg tgtatggctt tagccccggt acattttcgg 780 cgcaaagacc cttatttaga ccagtgagct gttacgcttt ctttaaatga tggctgcttc 840 taagccaaca tcctggttgt tttgggatcc tcacatcctt tcccacttag ccataactta 900 gggaccttag atggtggtca gggttgttgc cctcttcacg acggacgtta gcacccgccg 960 tgtgtctgcc cagtagtact ccccggtatt cggagtttga ttaggatcag taagacggtg 1020 agtccccata gcccattcag tgctctaccc ccgggggtat tcgctggacg ctctacctaa 1080 atagatttcg cggagaacca gctatctcca agtttgattg gsctttcacc cctanccaca 1140 agtcatcccg atctattgca acagatatgg gttcggtcct ccagtacgtg ttaccgtacc 1200 ttcaacctgc tcatggctag atcacttggt ttcgggtcta atccgacgaa ctgaacgcct 1260 gtcagactcg ctttcgctac gcctacacct accggcttaa gcttgctcgt cagactaagt 1320 cgctgaccca ttatacaaaa ggtacgctgt cacccagaac tgatcttggg ctccaactgt 1380 ttgtaggcat tcggtttcag gtactatttc actcccctcg tcggggtgct tttcaccttt 1440 ccctcacggt actggttcgc tatcggtcat gcacgagtac ttaggcttgg atcgtggtcg 1500 acccatgttc agacaggatt tcacgtgtcc cgccctactc aaggacttat gatcgttcta 1560 cgtgtacggg gctatcaccc actttagcca acctttccag attgttccac tttactcaca 1620 taagccactg gcctggtccg cgttcgctcg ccactactag cggagtctcg tttgatgtcc 1680 tttcctctgg gtacttagat gtttcagttc cccaggttcg cttctaaccc ctatgtattc 1740 agaattagat accttattac gataactaga aagttgaact gttcttgctt gcgcgccaac 1800 aattcaaatt ttctagctat ctaaggtggg ttgccccatt cggaaatcgt cggatcaaag 1860 ggtattcgca cctccccgac gcttatcgca gcgtatcacg tccttcatcg cctgtgcatg 1920 ccaaggcatc caccaaatgc ccttaagaca cttgatcact ctcattgcca atatccatca 1980 aaacatccgt cttgattata tcagcagaaa gaccagcttc tcgagataca atcggtggag 2040 cggttaggcg tccaatcata atgcaaggct tgagcaagct cttgcgacat tagccaaagg 2100 ctaatccgat tacatcttct cttcacgatt tcatacagaa caggcaaatt gctcaaagca 2160 atctgcaaac ttgtttcttt cttttgttga atgactacaa tccgtcctac tcgacaccaa 2220 aattgtgatg gtggagctta tcgggatcga accgatgacc ccctgcttgc aaagcaggtg 2280 ctctcccagc tgagctaaag ccccttatca catttatcaa agcaaagctt tgcaaggcca 2390 agcggccgtc gcagcccatg ctgcgctcac gcgaagtgcc agcagcgata gctgcgatac 2400 ggcacgtgag cgataatttg gtgggcctgg gaggacttga acctccgacc ccacgcttat 2460 caagcgtgtg ctctaaccaa ctgagctaca agcccctata ctatcgcatc cccatcaaga 250 gggcgccaat acaggacgct agtccgtcgc cactcgtgtg gcgcgctcgc gcagggccag 2580 cagcgttagc tgcgatacgg cccgtgagcg ggtcatgtca atcaacaatg aagaaagaga 2690 aacgaaggcg gcacgcctgc aaagcgatcg tcagagcgac tactctgcga tctatgttct 2700 aataagcatg agaaagttca tccacaataa attgcagcat cttactattc tacagcttcc 2760 ttagaaagga ggtgatccag ccgcaggttc ccctacggct accttgttac gacttcaccc 280 cagtcgctga ccctaccgtg gtcacctgcc tccttacggt tagcacagtg ccttcgggca 2980 gaaccaactc ccatggtgtg acgggcggtg tgtacaaggc ccgggaacgt attcaccgcg 2940 gcatgctgat ccgcgattac tagcgattcc aacttcatgc actcgagttg cagagtgcaa 3000 tccgaactga gatggctttt ggagattagc tcacactcgg gtgcttgctg cccactgtca 3060 ccaccattgt agcacgtgtg tagcccagcc cgtaagggcc atgaggactt gacgtcatcc 3120 ccaccttcct ccagcttatc actggcagtc cctttagagt gcccaactaa atgatggcaa 3180 ctaaaggcga gggttgcgct cgttgcggga cttaacccaa catctcacga cacgagctga 3290 cgacagccat gcagcacctg tatccggtcc agccgaactg aaagacacat ctctgtgtcc 3300 gcgaccggta tgtcaagggc tggtaaggtt ctgcgcgttg cttcgaatta aaccacatgc 3360 tccaccgctt gtgcgggccc ccgtcaattc ctttgagttt taatcttgcg accgtactcc 3420 ccaggcggaa tgtttaatgc gttagctgcg ccaccgaaga gtaaactccc cgacggctaa 3480 cattcatcgt ttacggcgtg gactaccagg gtatctaatc ctgtttgctc cccacgcttt 3540 cgcacctcag cgtcagtaat ggtccagtga gccgccttcg ccactggtgt tcctccgaat 3600 atctacgaat ttcacctcta cactcggaat tcvng*ynrm amhadatara grahntwhnm 3660 artndatnst athbcdcmbg tmsnwrmans ymbarahcbc whnmartnwh nmartnhddt 3?20 bcbwhnmart nnrmawhnma rtnmcrstwr dbbdhccdbc bcttdgdanb cdaa*rtntr 3780 ywnstamyta bbcdcddmwm wrddcmntda tncatsmmar ynrmatncdy dcmntsmmar 3890 ynrmatncmb mcrstwrddc mntmswrddc wrddcmnt 3878 <210> 20 <211> 2287 <212> DNA
<213> Stealth W rus <400> 20 gbbsbcgaat tccgcatcca gaactacgat ataacgacta tccgcaccag ttttcgggtg 60 gtcagcgtca gcgtatcgtt attgctatcg cattggcggg gtcgcctgaa atcatcatcg 120 ccgatgagcc aacttctgct cttgacgcca ccgtacaaaa acagattctt gcactgttgc 180 ggaagctagt tgatgaaacc gaggtgtcaa ttattctggt tacccatgat atgggcgtta 240 tcgcagaaat tgccgacaaa gttctggtga tgcgccacgg cagggtcgtc gaacagaacc 300 agacgagcgc catccttgat gcaccgcaag atgactatac gcgcaaattg ttggcggcag 360 tcccaagact tcatgtttcc agtggcgagc ttcggggtaa tggggcgacg acaagcgagg 420 ggaatgaggc acaggataaa gggattaggc gctctgccga tattcttgtt gccacagata 480 tctcgaaaag ctttcgttca gggggcgcgc catggccttt agcaagtgcg gtaccgcagc 590 aagcacttaa gaatgtttcg atccgcctaa agcgcggcac aatcacaggc attgtcggtg 600 aaagtggaag cggcaaaacc actatcggcc ggatcatcgc ggggctggaa acggcaagcg 660 atggcgaggt ttcgatcagc gggaaaaaat acgacgtcac gaagaagggg cgaaccagtg 720 gcatcctcgg gcgagtgcag atgatctttc aggatccgtc cgtctcactg aacccgcgca 780 tgaccatcgg tgatgctttg aacgaagccg ttcggtcgat taacaatgtt actggacaac 840 ggacaatact cggtattggc ccgatgatgg acaggctcaa tctcgccaga agctttctca 900 cccggtaccc acatcagctc tcaggtggac agaaacaacg tgtctgcatt gcaagagcac 960 tccttgctga tccgcaaatc atcgtcgccg atgagcccac ctcagcactc gacgtctccg 1020 ttcaggcgga gattatcgaa ctactgaagg aacggattat tgaagatgat atttcgatga 1090 tcttcatctc ccacgacctc gccgtcgttc aggatatttg cagccacatc tatattttcc 1140 gaaacgggcg tatcgaagat agcggcccat cgatatcaat cttttcgcaa tcgagaaatg 1200 cttacacgcg aagcctagtc gaggcgcggt cgaagcgatt tatccagtaa gaacagtcca 1260 ccaaatccat aagggcggcc gaccggcctg ggcggaatga caccgcgcca gattgtcgga 1320 ggtcagtcgc tattccaaaa atgaggacaa tcatgaacgg tagcttcacc atcacggtaa 1330 ccggacagtc tctgatcaag caggatacac gtggcatttt caatcccgga tttcaggatg 1440 tctctacact aatcaaaaac acggacctgg cttttacgaa ctttgaaggc accattttgg 1500 gccgttatgg cggctggcca ctgaagggat cattttttga ctgcagcaag ccggtggttc 1560 tggatgcatt acaggatatt ggctttcgtg cgctgtcgtt gtccaacaat cacgcatttg 1620 acctggggcc gtcgggcatc ctgtccacga tcgaggaggt cgatcagcgg ggctttttgc 1680 acgccggcat tgggcgcaac caccgcgaag cggcctgccc cagccttggt caaattggtc 1740 agcgtaaagt cgctatcgtc gctatggatg gcggccctgg ccctgatttc atgtatgccg 1800 atgattcagg gattgggcgt ccggaacgcc ccggtatcaa tcggctgggt atctcccaga 1860 tcatcgatgt cgacaacgat acattccagg agcttcgttc gatacgcgac aaggttggtt 1920 atacagagct tgccctgacc aatgacagtc agcccaacga tccatatccc gtcgacgaga 1980 caaaagaggt ttgcatcgga cgggcagtat tccgtcgatc aaaagaattc vngnrmamha 2040 dataragrah ntwhnmartn datnstathb cdcmbgtmsn wrmansymba rahbcwhnma 2100 rtnwhnmart nhddtbcbwh nmartnnrma whnmartnmc rstwrddhcc dbbcttdgda 2160 nbcdaa*rtn trywyvtabw rddcmntsmm arynrmatnd cmntsmmary nrmatndath 2220 hdcmbtathb cdcddmwsta thbcdcdatn stathbcdcm crstwrddcm ntmswrddcw 2280 rddcmnt 2287 <210> 21 <211> 2568 <212> DNA
<213> Stealth virus <400> 21 gbbnbcgaat tcaaagttaa agargggtgt ttcagcatca agccctgaag cttcaattga 60 agttttagaa agtcaaaaaa ttgctcttga atcacaattc agagctaaaa atgaacgtgt 120 aaatacaatt gctgccgaaa tcaattcaac tttagctctt aaaaatgatt atgaagctac 180 acgtcgtaaa ttaacagatg ctttctcagc taaaattggt gaaagagaaa gatcaaaaac 240 tttacttgaa caaagtagag aaagacttgc ttctcaatac aaaatgacat ttgaagcagc 300 tgaaaaagtt catcacttag aaatgaatcg tgatcaagct gaagaaattg ttcgtcaatt 360 aagagaagaa attgaaggct taggtaacgt taacttagaa gctcttgaac aattagttga 420 agaagaaaaa cgttacaatg aatatgccga aggtgaaaga gaattaagtg ctgcaaaaga 480 aacacttgaa agcgctattg cagacatgga taaaatcatt atcactcgtc taactaacat 540 tattaatgat gttaatgatg aatttaacaa tgtctttaga acaatgttcg gtggtggtac 600 tgcaaaatta tttttcagca accctaaaga tattttagaa tcaggtgttg aaatcgaagc 660 tcaacctcct ggaaaaaata ttaaaaacct taaattattc tcaggcggtg aaaaatcact 720 tatcgctatc tcattattat ttggtattct taaagctcgt ccattacctc tttgtatcct 780 tgacgaagtt gaagctgcac ttgacgaagc taatgttgtt cgttatgcag aataccttca 840 acaacttaaa gaaaaaactc aattcttggt tattacacac cgtcatggaa caatgtcaag 900 agttgacaca ttatttggtg caacaatgca aaaccgtggt gttacaagct tcttcagcat 960 tcaattagca gatgctaaaa aacttgttgc agacgaacaa aaagaagaat tagaaccttc 1020 aaacaaaaac aaataataat caaataatta ttgtgcttaa tcataggcac aatttttata 1080 tatttgccca atcaatctat aaaaaagctt tattagtaaa atccatcaat tttaaatgaa 1140 aaattgttga gaaaaatctc acaaatttaa ttattgaaaa taattataaa atattaaaat 1200 ttatattaat aaatatagcg aataatcatt tataattaga gtactaaaat tgaaaggcca 1260 agaatgagaa aatatcaacc tattcaaaat tcagcaagta tcgaaattgt tcaaaataac 130 cacgactaca aattcaatag tgtaagtagt cgtgtttatc gtgatccaaa aaatcaaata 1380 tcacctcgcg tttatcgcgt catccgtgct gaacaaatgc ttaagatttt aatcctttct 1440 atttcatttg taattatggc tgcttcaatt attctcttca cattagtcta tgctaaagtt 1500 ~5 ggtatcttca acaaagaaca aagattaatt ggctaccttg tactttttgg atcaagtgcc 1560 tttatctcaa tggcaattgg ttttaaaaat ctgattgaaa atattcaatg atctcacaca 1620 gttcaaagat atcgtgatgc agtaagtaat ggtgattaca cttcaagtag tacttttcat 1680 attgcttatc gtaagatagt acttaaagat gttaatttaa cttgaatgct tgtttttgtc 1740 ttaacatatc taggcattat tacagcaata gtttatggac tttatatgtc aaatcgttga 1800 tattatgaaa ctgatacatt aaaaatcaat tttgaatgag ctaaatgact tgatagaggt 1860 tttggcaaca caattctatt ctgtattatt agtgttatta ttatggcttc ttcaatagcg 1920 gcgtatattt taataagatt atttgataaa aaacgtttag ctgacattag tgattttctc 1980 ggtgaacgtt ctgttgaaat tcatgaacaa gttgagcaaa gcaaaaaaga tcgtaacaaa 2040 atgtgactta gaatttatct agtagtagtt gctttaacaa ttcttttacc tcttgcttta 2100 gctctagttg ctctttgaag atttattgtt aaacgtcgta aaaaggttgt agcttaaaaa 2160 aattataagg ttttaaaaag ccttattttt tattaaataa ttctattatt tacttgtttt 2220 atatacattt tagtcaaaat tatttttatt tttttgtttt tattttcaaa tttttgctta 2280 tacaattttt atatggaggc attaaatgga aaacacaaaa agaacaaaat taactaaaac 2340 atcatgaatt cwhanrmamh adataragra hntwhnmart ndatnstath bcdcmmmbgt 2900 msnwrmansy mbarahbcwh nmartnwhnm artnhddtbc bwhnmartnn rmawhnmart 2460 nmcrstwrdd hccdbbcttd gdanbcadaa ~rtntrytab wrddcmntsm marynrmatn 250 dcmntsmmar ynrmatncmb mcrstwrddc mntmswrddc wrddcmnt 2568 <210> 22 <211> 8387 <212> DNA
<213> Stealth virus <400> 22 rgbbcnbcga attctttctc gtgatctcgt ataaccccgg atatcaaagc gcggtcaagg 60 acctgaaaga gtccacgaag cagcggttcg ccgccttgca cttcagctat gcctccgcgg 120 accgggagcg agaaatcgtc gcggaagaag cgaaaataag cagtgagctt gcccgccaac 180 ttgttgcaat cgcaacggcg tcgcgcaacc ttgctggcaa gggcctggat gaaggcgcgt 290 cgacccgaac gttgatccgg gctgggcggt tgatcgcgca aggcataccg ccggcagatg 300 cgtgtgagct cgcgatcatc tcaccggtca cggacgacgt tgcagttcgg gacgcgctgc 360 gctccacggt aatggcatgt ctctaacctc cccgggacag gccttgcctg aagacgcaat 920 ggaatcacgg ctcatgggcc gcatggagct ttttacgtcc tacaggacta ctcggactga 480 actaggacgc gtgcatacct cgaaggaact tggcgagtgg atcgaaagca atttgcggct 540 attcgacgcc aacgccggac aaccgctttt ccagatgctc tggcgactgc aactccgcct 600 ggcgagatgt gctggcgctg ccgcattgat caaaatcgct gattcgacct atcacatgtg 660 tctttcctcc ggtgctttgg caaccacgag gtttctcgag gccgtgttga tcaggaccag 720 cttcgaagag acgggcgagg actggatctc cgcgttggcc ggaatagcta gactggcacc 780 gtgcgctcct gaaatggcag gggcgatagt gattaacctc tcgacgctgt tagagcacct 840 tgccgttgga aatatagcgg cttgggctga ggatgccttg cggctctacc ctcgcgaccg 900 gcagaagcga cttgcgtatt atcggcttga cgatccgacg gcgatagagc ggctcgctgc 960 ccatgaaggc atcgtaaggt ttgaggtgca tactggtcgg ctgacccatc tggtcaaagc 100 gctgttcaat cgggaactta aggtgcaagt cgtcccgcct catacagcaa cgtctatcca 1080 gcgaacccgg ctcgccggcg acgttattct tgtccctggt gtcccgccga acattgttcg 1140 tggcaaaggc tcggagtatt tcgaggcggc tgttttgcac ggactgtgcc accagacctt 1200 cacgccggcc cgttttcccg tcggaaagat gaagccgcta cagcttgcac tcgtctcgct 1260 gctggaagat gcccgtgtcg agcgtctcgc ggtgcgggag tggcctggca ttcaaagctt 130 ttggcttccc tttcatatgg atctcggtgt tcgagcccgc agcgccgagg ggctacttgc 1380 gcgactggcg cgtgctctag cggatccatc ccatgatgat gacgacgcct gggttcaaaa 1940 agggcggatg tttttcgaag ctgcgttcgc cgctaccccg aatgaccttc tcttctgtga 1500 gccggttggc gagggtcctc gggcatgatc tcggccagat gcggatccct ttcgacgcaa 1560 agtcttactt agtcactccg ccttacagag acgacggctt aggtctcttc caaattgacg 1620 atcccagcca atcagatgag gaaacgctcg aaatactcct cgacgcagca agaatcctgc 1680 cggatgaaga cccttccaaa cctgctgcgc cggaaggttc ggatcaatcg gcttcgataa 1740 agtttgtaga ggccgatcct gacaagggtg cgcttctggg cctctatccg gaatgggact 1800 acagactcgg gtcggaaacg aagtcggctg ttagtgtatt tgcagatcag ataacaacag 1860 tcggcagtcc gagctggctt gacgacgaac ttgcgataca tcgccgcgaa agcggcgcac 1920 tgcgcgcctt gctacgccgg tctagaacag gccgcaccgt gcgccttaag aaccgattgg 1980 atggcgacga tatcgacctc gatgctgttg tcgaaaacct ggtttcctgt cacgcgggcc 2040 acacacctga tccgcgcctg tattcggtga aacgtcgtct cgaacgcgat gtatcgatgg 2100 cgttgctggt cgatacatcg cagtccacgg cctcacggaa agacccgacg actcccagtg 2160 tcctggaaac cgcggtggtt gcgacggctc ttctaggcga ggcgctctcc gaacttaacg 2220 acccgttcgc aatcttttcg ttctgctcta atggcaaaga tgacgttcga cttggcgcgg 2280 tcaaggattt caatgagccg tttgccgggt ctgttccgcg tcttgccggt ttgcaggcta 2340 ggttctcgac gcgcttggga gccggtgttc gtcatgtcgc cacgaagttg cacgtacaga 2400 gaacaatgag aaaggtcctt atcgtcataa ccgacggcga gcccgctgac cgtgatgtcg 2460 atgatccgga atttttgacg gaggatgcac ggcacgccat tgcaggcgcc cggtcagctg 2520 gcatggatct cttttgcgta gtgattggcg atcaggcgct ccctgtcgcg tcacgaatgt 2580 tcggcaaacg aaatacgctc tcggtgtatc gcatcgagga ccttatccca cgtctatctg 2640 aattgtactt taggttgacg gtaaattagg agtcaccaaa accatgcaaa gccggttcgg 2700 ctcaagcgat catcgcgatg tcgatcggga actggcccgt acccgctcac agcttcccga 2760 agttgcggtg aatgccgatc ggatcaggga cgtggcccgg atcacgcaca ggacgcggga 2820 gacggtgatc cagcgcgatt atgcacttga gcgggcgcaa cagcagaaac tcgacatgga 2880 gcgcggtcgg tcgcgggagc cagatcgggg cttggagcgg taagtggcga gctgccgggt 2940 attctgtcag tgtcggctcg ccgccagctc tcacgggaca aatgagacgc gccgcatccg 3000 cacagcgttc ggcgctcgcg atctttccga cgatgaagca tgccggcttt gcgatgcgct 3060 tgaaaaaagc gtggtgcaaa gccctgacag cgtgggaaca cgttgagctg cacaaaagag 3120 ttgagcagtt tcagccggtt gtaattcagt tcggttggga gcatcaccgg ataatggtct 3180 ttgagcgcta tcgtcttact cgcaatcgcg ccgatatcac cgycctagat acactttcac 3240 caaatgcccg atctcaccat gcgcctgaac catcgcagcg gagcttggcg gagtgttgtc 3300 gtgacaagcg ttgttgacgg tgtttttgaa ggcagcgaac tttcccgcat gggagggatc 3360 gcgagataat agatgctcca ttctcggaga cagccattcc atggttttgc cgtcatagtc 3420 ggacagtgag gcgaccatat ctcctgaggt gtgccgatcg ctaaccaaga tttccttgca 3980 gaagcgttcg ccggcatccc gcaactggat tccgcattct ttcctcaaat caggatggcc 3540 gccacgcgct agcgattttg cacggttgag ctttgctaga agtgcgtcac tggtgttctc 3600 gatgatggtc cccttcccgg ctgtctctat gaacagctgt gctgtcgaga caccgaggtg 3660 acgataccga atttccaact cttcccaggt tccatggtcc tgtgtcagta caatcacctg 3720 gatcggcaag ttgagcagtg ccgaaagcac ccccgcattg aaatgaccgc gatagtcctc 3780 atcacttgaa agcacagggt catccagaat gatgaaaccg accccttcat gttccgcgcg 3840 agcaagaaac agcgccagtc ccaggcagtg aagttgtgac tggctgaaaa ttgcaatgac 3900 gtcgcgcagt tttgcggcct ctctgtctgt cgtggcagtc aagccggcct tgaaatcgat 3960 tgtcctcttc gcgcctttcc gaggctgaac agcagagaag aaagtcggct catccggccg 4020 gagaagctcc caccaggcct ggatagcttc gctatattca gagaactttt cttcgagcac 4080 cttttctttt gctgcatcga cctgctttag ggccgtctcc agctcctttg ataccgtcgt 4140 gaccgccctt cgttcaacga gtgcgctacg aagtcctctc ggatctgcag cgagttctag 9200 aagatcctgc catcccgtag tgtccgactt cgcatccaaa atagaggtga gcgcttggcg 4260 taaggtctga gctgcggcgt cgtaagcctc cagggcgtct gagaaggatt ttcgtagcct 4320 agccacctct tggaagtcca ccttcagctt ttccttttca atttcggcag cacttatgtc 4380 gtcaacatgc ttttccaaca gcaccttgag cgctgaagcc cgctgcctaa gtttcgacga 9440 gatgaggaga accggacgga cggccacaag ccacggccca acaactgcat cggctccgtc 4500 cccaagtagt tcgtgcaaac gagcaactgt gaaaccggca tcccgtcgct tcctgccagg 9560 ggttttgaaa aattcaggca aagccgcctt ggcagcatca gccaggctat cagcgctcgt 4620 cataagccgg cctaaggccg cctttgcatt ggcctctgca gttttgaaat cttttgttgc 4680 agcaacgtgc tgccgtaaaa gttcaacccg tgcaggcgtc agggcatctt cgacgccaca 4740 caacgggcag tccacctgct cggttgtttc ggctatatca ggcaatttga gcgcctcgac 4800 aaaaagcgcg gcaagctgcc gcgtttcttc gtctaccttc gccttttcgc cggtataaag 9860 ctcgatttgg gaccagttct cgtcgtccgg acaactccat ccggccagtg cggatcgctc 4920 gaagttccgg attggaaaag ttttactacg gagctcagtg agtagctcgt tcagggccga 9980 ataccgctcc tcagaagtgg ccggtatggt ctggttcgca tcttcgagca gtaatcgcac 5040 acattcatca agctgctccc taatctgagc tgcttcggga agtttgcttt cgaccttcga 5100 taaaactggc tgcatgagcc ggtgggcggc acaggaatcg aactgcgcaa gggctggatc 5160 gtcaggctgc cgaaagtctg cctctaggcc cgcaatcatg ttccggagtt catccagatc 5220 agtcacttca aaaagtgctt tgaagtaagt ggcgcgatcc tggggcttta ctgaaaaaat 5280 gtagctgagg gtgtgttgtg ccagtaccgg tgcttgaaga ggcggctgag ataggacgat 5340 accaagggcg acaagatcag actcttgtgc cggcgcacca tcaatctcta gtcgcgaagc 5900 gcagttctga cgtttggcgt agtctgctgt cagaactcgc ttaacaacgt gttctgtgcc 5460 gtcgggagct acgatcctcg ccgccacata gacctcgtga ttcactggca aatgagcgtt 5520 gcgaagagcg tctgcaaact cgtcttgact gctcgccatc atctcacgcc gtgagatgca 5580 gccggtcaaa agaaattcaa aagcctcccc taggctgctc ttccccttgc tgtttggtcc 5640 ccacacaacg gcgagatcac tggggagact caacgtctgc tctgtaccgc catatgcacg 5700 aaagcctttg aggctgagtg acctaattct tgctaccaag gtcctgcctc acttgttcga 5760 gcctttcggt crcaatgcgt ttcaacgcgt cgcgatcacc cctggaatca aggtgtgctt 5820 gaaccaggag cgaagacaaa gtctccggct traggtgctt ttgtaggcgt tcgctattac 5880 tctctggctc cagagcagcc tcgctatttt gcatgtgtta ccccccatag catggtgcct 5940 gcttcgttcg attttgcaag tttattgcgc cttcgcacca ttcaaaatgg accgattgtt 6000 ggacatcaac accgagagga taaaagtgct ccaaggatat atcgttcgcg tccaacaaat 6060 acgtctacta ttctattgcc yaataatcgg tattgaatca gaatctggac atgctcatcg 6120 gttacgcgcg cgtctcaacc acagatcaga acctcgacct ccagcgggat gcgcttcaac 6180 gcgccggctg ccagaagatt ttcgaagaga agaaatccgg cagggccggc accaagcggc 6290 aggagttcga tgccgctctt gcctacctgc gcgctgaaga cgttctggta gtgtggaagc 6300 tagaccgact gggtcgatcg ctcgtcgaga tgatgcgcac gattgatggc ctgcagaaga 6360 acggcgtcat gtttcaaagc ctgaccgagc acttcgatag cgagactgcc catggccgtt 690 tcgctctcca gatgcacggc gccatggcgg aatacttcct cgatctcaat cgagaacgca 6480 ccatggaagg cctgaaagcc gccttggcgc gcgggaagaa aggtgggcga ccgcgcaagc 6540 tatcggagrc cgaccttgaa gcaggcaagg cgatgctggt cgccggcact attcctgttg 6600 cgcagatcgc caagcggctg ggcctcagcc gggccggatt ctacaactac tttccgcaag 6660 cccgtgcaac agccttggtc aaggaggatc gttgatgccg atccgtaaaa ctctctcata 6720 tctctgtaaa gccggatgca acgatgctga aaactgacac ccgccaagcg aattggcgtc 6780 gtgccaatcg atcggcctgg aagccgagca ggacttgata tctgatcttg cgtccagtct 6890 ggccgcgacc ggaaccagct ctcgaaaaca aacctgaatt tggaaagaac cgatcgacgt 6900 ttcccaccat tatgccacgt attgcgatag catcagcggt aaccgaagcc catcacgtag 6960 tcgcgcatta acgcctcttc tgtcgtggac tccttgagca gcgcctgcag tatatccctg 7020 gcgttgagca cgcccaacgg acgggactcc tcgtcaacaa atgggatgtt tttcaggctt 7080 ctttcattca tgcggtgcca tagatcctcc agcagatctc ctgactgaca aagcatgaca 7190 ~8 WO 99/34019 PCf/US98/27744 tcttgcgtca tcgcaatgga cgacgatgcc aggcaacctg ccccctggca ctggctgatc 7200 tgagcgacga catcggtctt ggtgataacg cctcgcagga tgccagtggc gctacaaacg 7260 agcaaaatat cggttcctga cccaagaagc cgcgcagcct cgattagatg cgcatcatca 7320 gcgatagtga caagccgttc acgcgcttcc ggtaacaaac tctcaacaaa catcacctgt 7380 cccatccaaa atgcaacccc acggacccac agccatagcc tatcacaagt gtgagtaagg 7440 tgtaatgctg tgaacagaca atatttagcc acgataaagc ggacgcaccc acgaacgcag 7500 cagccatcgt ggtcgtggaa tggatgtatt cctcgatcac aattctgggc caagatgctg 7560 gtaaccggac acccaggcca gcgggtaaag ctaatattcg aggcgaaatc actacactat 7620 tctcgtatat cactttcggc tggataaatt aaaccttccc cattcatgac agctccaggc 7680 gtcatgctgg cctcattgac ttgcgatgac cccaggatgt gcatcacgct ttcgccttgg 7790 ctgatcaggt agtccgtgat gatccgccga tgacagcgcc accatacagc ctctgcacac 7800 atgattgcgc agcggtgttt gtttcctagc gccctgagtt gggcaagtcc gtcggcaaac 7860 ggcgcactca acgcatagtc tgcatagtta cggaagctgc gtacgcgcca aaacccgttc 7920 ggcgactgct ccaaattccg cgtcttacct cgaagcccgc caagtgtcgc aatatgttga 7980 tagccaattt gccaaggcgc caacgttgcg gggaggcaat cgccgttgaa ctgcggatta 8040 gtgcgcgaac gcggcattat tctcacatca acgacgaaat caacgcggga ctctcggagc 8100 agatcgacga attcwha*yw vtsrnmkhg* ***dcbanrm amhadatara grahnt*whn 8160 martndatns tathbcdcmv vbgtmsnwrm ansymbarah bcwhnmartn whnmartnhd 8220 dtbcbwhnma rtnnrmawhn martnmcrst wrddhccdbb cttdgdanbc bdaa*abcdh 8280 kmnrtntrya stabwrddcm ntsmmarynr matndcmnts mmarynrmat nwgcmbkttr 8340 sadmnstrat rdskbwwcwm crstwrddcm ntmswrddcw rddcmnt 8387 <210> 23 <211> 6088 <212> DNA
<213> Stealth virus <900> 23 cbgbbrvgnv vvvkvbcgaa ttcaaagact tgaccgtctt ggatgacggc aagcgaggaa 60 acttgagaga ctggctaagg aaaaaatatg agcactggcg ctacggaccc tccggagggt 120 ctaacagagt tgagtattat tcgccacccg acgaacgcgc cggcgagacc agagaggaga 180 tggttactat ccagccgccg cctcccaaac aaactgtggt gactatagag ggcggacaga 240 ctgtgaccaa aatctacaaa gggcaacctg actcaactga gcagtgcgag cggccgagcg 300 tagctgaacc gctgatgatc gttcaacatg aacttgaatg cgccatcaca atggacggtg 360 atgaggcctc ctgagctatt gtgtgcgggc aggcggacgt gggacggacc accgtgacgc 920 agcttcagag actaataagt tttcaccgtt ccccgcctgc gctgcctgca gctaaaaggc 480 ctgtgagctg gacgctcaga actatggacc tggccgtgct agtggccacc gtgttggcga 590 ttatcattct gttgatgatc gttatttcta tctgctgcgc taaaccttgg cggagcccga 600 actcgcgcta cttcaaccct ccgtttctgg tgtacagcaw gagatccgcg agaggggcgg 660 acgaggactt ggagccctgc ttcgaggaca ctgtgctgat tcttgaggct atgagcccgc 720 agcccgtccc gcagtaaacc ctcaccatgc gcgccgtgcg gttcagaaaa ggtccgagag 78:) aagacggagc ggtcgatgaa accgcgctgc tggtgaccga gtgggagtct ccggaccacc 840 cctcggacgc ggattcggcc ctggaacaga ctattgagga cgagcgagcc agactcgtgt 900 cctccgtgcc ggtgccggct c~gcgagccg cgatgttttt gcgacgcgcc acggtggcct 960 tgaccgtcct gttggtggct ctaacgccgc gggtgaaggc ggacatcgat tacctgatgt 100 gggacgagtg ctacgacagc ggctctccgg caccgctcat tatgccgctg ggatcccaca 1080 tcacggtgcc ctgcaccttt ttgcctcact cgtggccgat gatttccatc cgcgctcggt 1140 tctgtcaatc cgagtatgcg ggtcacgaac tggtggtgaa cgtcaccaac ggaacgctag 1200 acactgatgg actgacccct cttttgcaca atgctagctg gaaatttgta gacatgactc 1260 ttggacattc tgtaatgctg tttttcaata taactgataa caccactggc atgtttgatt 1320 gtttgttgcg caacgagact cacggttaca tgaccacgcg gtttacggtc attacacaga 1380 tagagacttt gcacagacca ggggagcgtg agtgtgtgcc taagttggga tttaaatccg 1440 atggtgataa gatttggacc actgaacaca atgagtggca gcgccataac tgtgggactt 1500 tctacggctt tgacaggctg tactactatt tggtcgctac taacgagtcc aacaccaaac 1560 cgccttgccc cccgaacgaa cccgatcgtt gttggcccgt cgtgcagcgg tatactttgg 1620 acggggactg ctaccgcatc caggctcctc gacgccgcaa gttgcgtcct tactctaatc 1680 atgagggcgg acacggacta cggtttacgg atgtgccctg gttgaccctg ggaatgactg 1740 tgatgttcat aggaggtgtg tgcatggggc tggtggtggt ggttcgcctg gcgtgcggcg 1800 agtgttgccg caactacgag cgctttaaaa agaagagacg cggctaccga cccctgtctg 1860 gacagtttat gcgtgcgccc gactacgacg agctgtaccc cagcgaggag gcgttcagca 1920 agtcatacga ggagctgttc aatactcaag ctaatgatac ctatccagaa ccccccttgt 1980 atagtgaagt tcagttcccc ttgtatagtg aaataaagag acgcttgtaa gctttcacaa 2040 ttggcgcgtt tatgattgtg ttctgtgcgt gtgtggcgtg ttggaagcgt ckggtgccgg 2100 agggtaagat ggcggattgg ggcacgtgta tttacctgac ggtgttcggt tcgtaaaccg 2160 ctggcccgtc aacaacaccg cgcaataggg tcagtcaggg gacggcggcg cgggtccgag 2220 aaccatgagc caacccagag gaatatgctg ctactgccgg tcgtctggac cgttgtcgtg 2280 gcaagtgggt ccgccgcatc cccgtgtaag ccgaatgagt acgcggtggg ttcggagtgc 2340 tgcccgaagt gcggtaacgc aggctacagg gtaagaacga actgtagcga atccaccggg 2900 acggtctgcg agccctgtcc gccgggatca tacaataaca acaccgacag gattaactgc 2460 accgcgtgtg acatatgcaa cgcctcgtcc gtagcggtga aaaattgcac cgccacccag 250 aacgcaagat gccggccgat caacagtact gttacgcact tagatgccag accgagtcac 2580 cacggcggca accactcgtg ggaatcggac tacgactcga ctcgggactg gtggttcata 2690 ctggtgtttg tggtgtttct gttttccgtg atcctactga tcctgggctg cagactgatt 2700 ctgttacaca ccacgtacgg caagatgctg acggcttaca tgtatgaaag gattacgtga 2760 gatgttgtga actgttgtga gatgtgatga atgttagata atggcataac ccagatgtcc 2820 gtgtccccgt ttgatcaact ccaccatacg tgttttatta gcctaacctg ttcacgcaac 2880 cacattgcac ataataaaac aatctcagtc acgatgcgag tctgatatgt ttattggtat 2940 ttgtacctac ctgcgcgatt tcccctgagc actttagtat cggacacgtg acgagcggcg 3000 acgaatccgg gcgtacggtg acggaatatt tccgtctgat gggctttata agtccgattg 3060 taaatcgcat cggtccccct cgaaaacatc atggtctttt atcagtaccg caacgccgtg 310 cagttactgt ccgcgcgacc tcgcgacggg ccgggacgct gggagcgctt gacacaccac 3180 gcggcctacg ccgccgacca cggggcctgc accgtactga tggctacctc acagagactc 3290 tccctcgtcc tccggaggca tagcgccata tctgctgtca ccctacgcct tatccctgct 3300 aaaatcctga agaaacttga agaatcggaa tggattccgg gcgcctggat cgcttcagag 3360 acgttcccta cttcggacgt tatcatctga taacaatgca catgcatact atgggacacg 3920 aatactggac actgtccgag ctgctaattt gtctatgaag aagaccaatt gcgcttaatc 3480 aatttccgtt actgtgaacg ccattatgcg gcctgttgca ctactgatcc gtcttctgtg 3540 ttgctgctac ttactttcgg tactaccctt gactggccgc ccgttatcct aaacgccgtt 3600 atgcggcgtt tggtactgat ttgttttttg tgttgctgct acttatgcac ggtacgaccc 3660 gccactacac gacaagaaca ctgtccttgc gggaatacga agccattaaa ctttatacct 370 ccgaaagcgg attgtctatg gattcatcgt tctgatggac cttgcggtaa cgaagttaca 3780 gcccactttc cacccacagt aacaaagaca aatggaaaac cgcggaaacc actgtgcttg 3840 aactacacat atgttgacaa tgtcgttaaa aacgtaactg acgatggaac ttattgcata 3900 cataaaaacg ttactaaatg gctactaacg acatgtacca actgcacacc aacaactttg 3960 taccaaagag ttagcgatat tcgggaaaaa gaatggtggt tgtggcagcg aatcccaaac 400 ttgtggaggt agggtaaaat gtaaagcaat acaaatatga ttttttaagg cagcttcatt 4080 aagtaaagat taatcggtaa ttgaaccgtt atgtgtatcc gtgcagtatg tatttttcta 4140 tgtatcatcc tgttaggtac gtacagtgtt ggaactaaag agcatcggtg taattgtatc 4200 gggagttata ataaacgacc tctaccaaga ggaatacaat gtgtttggat taactatccc 4260 agtgcagcat gtgacaaaat tgaagctata gcatatttca attatacggt tagaaaaaca 9320 cctgtctgct tacattacca aacctatcaa cgtaggcttc ccccatcccc tggagcctgg 4380 tgttggctta acaaaaccca cgtagtaaaa gtacacgact gggactgtaa atggtgccac 4940 cgttttgaac cttacatggg cgtgtctcat tgatagtaca cccagataat tgaaaatgct 9500 aatatacatt gatgctccga acactcaaca gctcacggtt attcttgtga aaatcaaaca 4560 acatatcaag gtaaaacaac cgccatgaat gtaatgtgga gtcctcggtt tctggctgta 4620 gctctactga ttgttagttt gattgcatac agcgaatcct cgcaaggaat acgttgtgag 4680 tgtaaaaaag gtacacaaaa gattcctgaa aataaaatcg ttgtaaagaa aatgaagaga 4740 ccatcaggac ctaatcaccc ccgtacagaa gttaaagatt ccacaaaaca accaggtaga 4800 gatccaatgg gacgaccagt ctccatatag caccctaaga aaaattgaag atgtttatct 4860 acacacaatc ctcaaacgag ccagaactca cgtttattgt cgtacgaaga aaacaacaaa 4920 ctaacaaaaa gaaaccgcca tgaaagctct atacaatccc cggtttctcg gtgtgaccct 4980 actattgatg agtctgattg cttactgcca atccacaacc gaactgcgtt gccagtgcac 5040 acaaaccgtg caagggattc atccaaagaa catccaaagc gtgagcatca aagacaaagg 5100 acctaactgc cccaaccagg aagttatagc tacactgaag aacggacaaa aagtctgctt 5160 gaatcccaca gcacctatgg tgcaaaaaat tttaaagaag acgataacag ataattaaac 5220 ttgctttacg ttttgataga tcggcaataa accagttggg aacgtttaca ccgctttaca 5280 atagatgtga aaataccaat cgtgcaacag accgctctta ccggatgaat ctgcaacgtt 5390 tcctgagcta ccatgaaaac aagccaagag ccaaacatgt caatcatcga atcgctttgg 5400 aagttgctca gagcaacggt tagtttattc atagaaactt acatcgttac aaaagcaaac 5960 cgtaatgcaa tattctctat cacacttgtt ggtggcgacc ctgttgggta cgctactagc 5520 atccactatg gtgtttgctg ataaagaaga acgttgtctt tgccccaaaa ccatacaagg 5580 gattcatccg aaaaacattc aatctgttga actgcatgaa ccaagagaca tgtgtcctaa 5690 cgttgaagtc atgtaagttt gttggtattg cgttatcatc ggtaaattgg cgcatgagat 5700 aacttacaat tccttatact tttcctattt acacagcgcc aaactgaaaa acggaaatga 5760 agtttgcctt aacacagagg gtcccatggt taagaagatt attgaaaaaa tgagagatcg 5820 tgaaattgaa agaattcwha *ywvtsrnmn rmamhadata ragrahntrw hnmartndat 5880 nstathbcdc mbgtmsnwrm ansymbarah bcwhnmartn whnmartnhd dtbcbwhnma 5940 rtnnrmawhn martnmcrst wrdmmdhccd bbcttdgdan bcdaaadrtn trytab*wrd 6000 dcmntrsmma rynrmatndc mntsmmaryn rmatnbcmbc cbccbbbbbb bbbbbbbatc 6060 mcrstwrddc mntmswrddc wrddcmnt 6088 <210> 24 <211> 5059 <212> DNA
<213> Stealth W rus <400> 29 tvsgbbtnnn nnnnbbbbbn bvwvvvvvn vvvwnnvvv vnvnvbbnnn nvrnnvbbbs 60 tathadatat nanarcangr nmnkysmanc ytmgavrsam arnctnthca rmmnsystms 120 trcgnandrs ndtvrsnctn sasccssmmn rsnscanrad catrgnvrss bydstr,~ngn 180 ctdcsrrtth rasrgnyvrs ssymtmsana ctvrsnctnm ayccrdrngt htmrdrrdtg 29n nratarmary carmmnrsns andcanasba byrdctcarm mndamagnct dnvranctdc 300 snsaysvrnc tnscanccrt hmmnsystms mardramasa rstmmatrty chmthraycn 36.) cdntnctnwt hhmanmmndc ncyvrshvrs ccgntcdcts nmmncmtncc rtanvrssma 42~) yasntrrwth mmngcadnss thrghschmc hansmsasdw nrgatnthrs snhstcmatb 480 tyantgnsnd ctnmmnsrss vcytknsand ratdvrknsa ndbyrmanng nactvascan 540 ccrnatntnc tnsstathad atatnwasrs dasadstnct rcsswhrbya vrscdrmana 600 ctvycytath cnthabsnca naccmanyng nammatryca rmmnrsnsba sdnasrshst 660 gcandngsan dnzatdsatn satycaystr ctrdcytath cvrsstwass ggstdthatt 720 hsvrssackd crtcagnsnc dngctvtarg tsrthcarmm nsystmsncs tdsnarttys 780 tathadatdv rshasrvddd atacnsstnt wththshyth ssthrstsrs ntdnthsarc 840 nrmthdrvat nthsvrsrma narcangrnm nkysmancyt mgavrsscmv thdatadntt 900 yaarntgntc dtnswthnth vrsncdngth rgnthatncd thmarmmngn ctargtrhma 960 nantcytmga vrscarmmnt ythvrshasa sacrdaddtn asncsnratd tthscnvntn 1020 ahmanandan macytmgavr ssmatrasan dmthdsrsts atastartas ncnghasbnb 1080 tandnvrcns rmthvrsrma nythcnsths ncngmrycmr saratvyshr tradtrmtht 1140 andtrmtrst sthbscrtas mdrsctdcns cmtsncngha sbnbtandsv rathcnscnt 1200 andsncstha tcdbstatst cayagndbyb astnanayss tatastsmrt nthrtncdng 1260 rgnsthhman cytmgavrsh cmvgnmthba strgramwhc hsbasdnthd dcdamnacds 1320 ncscddbyan ctdsncdntd manyaddtna cnswthsgnc antartasnc hmgytvarsh 1380 cmvrtnsths rgramdsntr rthddcdrtn tbcddbyasn gnradngram andcantrat 1440 varstysnsr tsanddtnst hatcdrcdtr anscrtnanc tnamrnamca nvrandcatn 1500 thhcmvrtns rwhchatast smrtnscdba gndwthasnc cntandnnrm rthstathvr 1560 scnssshwnn tabthhcmvr tnswhchmat chdtvrmrth stathvrscn sarndcatdb 1620 yndrnngthm atchngrgns thhcmvgnmr whchnctdan damnacdsnc dataaravaa 1680 brrhsscytm gavrsrhcmv wrachcmard tthcrrsndn gstathvrss ncthsanays 1740 sshwdasgnc antyhghrba stnandbast hmgythstat hvrssncstr hcmvcmardt 1800 hcmvrsmthm atchngsncs anaddtnacm arsncdbmad wththgnban kntrsrscmv 1860 nthscassan vngratrhmg ywassnwths cmvthanrrh cmvstratvs tathvrssnc 1920 snwhchcmar snscdbmadw thcrrsndng sncsnhcmvr hcmvandrsc mvarshwnnt 1980 abthmatchn gthstathvr ssncstthhc mvandwhnav aabtthrhcm vandscmvgn 2040 mscmmnyshw dasmarstat hvrscnthan thcrrsndng rgnccrrngw thnthhcmvg 2100 nmanamsrvd dbystathvr scnbbastan ayssthscns hwsamnacds ncscrrsndn 2160 gtthandrtn shcmvthscn cmrssnynct dscmardtnc tdsthcrrsn dngcdngrgn 2220 hcmvsmthst athvrscnsc ntandsmasg mntswhataa rdtbnsrtds ncsthatcar 2280 ydstngshdt hstathvrsr mthcrrsndn ghcmvrhcmv rscmvgnman amsrvddwth 2340 cnnthscasa ndnsvrathr amsthnsrtd sncswdbctd tdsrtthrad trmasngnra 2400 dngrammtvr mnrdrncsan dccasnamar sncdrncswr rsntbtwndr ntcnsthatc 2460 arymatchdt smarrgnsth hcmvgnmams arshwndscs snthgnmthy sncdadstra 2520 nhcmvcmrss nctdsbasar sandtntayc dsratastrt nsrshcncas atshcmvcnt 2580 ansmaddtna rtncdngsnc sntrsntnth abratryada tdadstranm tdsncsarav 2690 aabnthcytm gavrssthrs csvrathrsa gnracnsrva tnsncsthsv rssawngrcm 2700 aranstbmad wthhcmvsnc cmarsnsbtw nthstathvr sandthshcm vrhcmvands 2760 cmvsrtrrar gmntsrthdr vatnthstat hvrsrmscmv thnctdandr tnmatchngr 2820 gnsthstath vrsardstrb tdthrghtmc hthhcmvgnm thmatchngs ncswrntnrm 2880 aydstrbtdt hrghthhcmv gnmramcnsw rndthatmat chdtthrgna scanbsnrmt 2940 absmrtncdn grgnshcmvw rntrrsntdb yanythcnsr mwhchsncda tahavsarbn 3000 btandnartc arthrwasnh mgydntdwth thwrmatrrt nwhchsthma rtargtrcyt 3060 tctcmdatdm mntyaganst hcmvthsndn gscnsstntw ththndryng assmtncncr 3120 nnggndtnas amansrstat hadatdvrss tbyasscarm mndnsmchan smsathghnt 3180 sccaydtrmn dnthsstdyt haggrgatng thsthcndst athvradnas ncsthatmat 3240 chtnnvrang rgnsthhcmv gnmrbabycd skbsncthst athvrsdnam gratsnagar 3300 sgswthasny armatykbas tsassmdtha tthgnmcnss tsmtragmnt srathrthan 3300 asanntrngt hcytmgavra gnmtabhcmv rtnsdntdby hmgysarchn gsngsncsnt 3420 hdnatractd rmctrsstat hvrsssssss sssssthdsg natnrrstrt nsncddbyth 3980 nngrgnhcmv srrstthnsh rtrgnmstth sncswrbtan drmthadstr anhcmvanda 3540 rntrsntnth adstranbta rrsntnthtd stranhcmvh cmvrtnstat hvrscnswth 3600 hrngy*btbt* btbt*btbtb tbtbtbtct* *btbtbt*ct **btbtctct btctCt*c*b 3660 tbtcbtbtbt btbtbtbtbt *btbtbtbtb tctctct*ct ct*btbt*bt bt*btbtct* 3720 btbtctctct c**ctctct* btbtbt*ct* *btbtbtbtb tbtct*ctct btctctb*ct 3780 ctctctbbtb b*ctbbtc** btbtctctct c**ctct**b tbt*bt*btb tbtbtbtbtb 3840 *btbtctbtC tb*btb*bt* bt*ctctctc tctct*ctct ctct**btbt btbtbtbb*c 3900 tctctbtb*b tbtbtbtctc **ct*ct'ct ctct*ctct* *ctbtctctc t*bt*btbtc 3960 t*bt*ctctc tct*ctctct ctctct*ct* *btbtbtsss ssssssssss sssss*ctct 4020 ctsss*ctct s*ctbtbtbt s*ctctbtbt btbtbts*bt btctcts*bt bts*btbtbt 4080 btbtbts*bt s*btbtbtbt btbtbtbtbt ctcts*btbt btbtscttab cmarsnthst 4140 athvrssnch mgswthcytm gavrsshman andrmatrgn shmgytcytm gavrssdrnt 4200 scsstathvr scnbastnba strgngnmhc mvrhcmvscm vhcmvrhcmv scmvbtnsbt 4260 snsbtmnsns ccabcdcabc abghnvghnd bbabghnvgh nbbcdvbgba gnbcdbbstv 4320 bbcktbbghn tbabchbvwk rbrwyyhb** ********** *w******** b***'*'*** 4380 ********** *******db* ******cdbc dkmstcdkms tbbbdbkrwy gmnstbghnb 4940 ntghmvwybd chmsbbydbd bdbdbdbdbn rmamhhadng dadataragr ahntsbdytt 9500 ndntdttdct r**cn*dngv *sgv***cbm rwhnmartna stathsncsd cwhnmartna 9560 stathsncsd cwhnmartna stathsncsd cwhnmartna stathsncsd cwhnmartna 460 stathsncsd cwhnmartnd atnstathbt dcwhnmartn datnstathb tdcwhnmart 4680 ndatnstath btdcwhnmar tndatnstat hbtdcwhnma rtndatnsta thbcdcbgtm 4740 snwrmansym barahdstat hadatatnan arcangrnmn kysmancytm gavrswhnma 4800 rtnwhnmart nhhtstatha datatnanar cangrnmnky smancytmga vrsmtawhnm 4860 artnnrmawh nmartnmcrs twrdnndthc cdstathada tatnanarca ngrnmnkysm 490 ancytmgavr sttdgdancd dda*abdghm nrrtntrygw nstarwtabb cdcddmwwvw 4980 rddcmntdat cdctsmmary nrmatndccd cmntsmmary nrmatnkcmb dmcrstwrdd 5040 cmntmswrdd cwrddcmnt 5059 <210> 25 <211> 2275 <212> DNA
<213> Stealth virus <400> 25 gbbnbcgaat tctatattat ttagtaaagc atctttgaat tgttgagttc ataaccataa 60 attttcttta aagcaggata aattatgttg gcatagccta aaccttgaaa gttagcatag 12~
ttaaagcctg attgaagaaa ataacttctt aaagcaacaa taatgtaagt tcaaattgaa 180 agctttttag tttgagcttg attaacttgc acaaaatctt tgttattaga ttccatcttg 240 ttgacctccc ttgttatttt cattattact gcttgtgtta cttatgtttc gagctactcc 300 agctgcttct ttaatacctg ctagtttttt tattgatatt atgatcaaga caaaggccat 360 ggcagtaaga gcaagagcta atactgagaa tgcttgacct gtaatttttg aaataacttc 420 aaataccaga gctaaaaagt aacctaataa agcaaaacca atatattctt ttttgagcat 980 aacttttaat attaaagcaa aacctaaagc aggaagcata ccaccagcaa ctcttaatcc 540 agttcttaat caatctggaa tactgcttga gaatctagct atcccattag ctgaaacacc 600 aactaataaa ccaaatccaa atgtaacaat Cattaagact aaaatagtta catgagatag 66.7 ~3 *rB

WO 99/34019 PCT~S9~~~~
gaatttaaac attttaaatt tgccttttgt aatttgtttt ttagccattt cacttnatcg 720 gtgacattaa tgtgaataat aatgtagtta ataattgcat taatattcct actggaattg 780 aatatccaat ataaatacct gcatccccaa ttgaaatagg ttgtgtgctt ccatgttttt 840 caacaattgc aacaactgtg gcaaaaatac ctggtgcaat tggmntccgg cggtctaaca 900 ccaccttgtg aaataccaaa gcctaatcaa acagtttgac cagcagctcc aacaataaca 960 gcggtttgaa tatcccctaa aattattcca acacctaaag cataaactat tggtgttgct 1020 gtataggtcc ccatcantag tacctgttat tgctaccgcg gctcaaactc cgataaagat 1080 agcttgaata attgaaattt ccattttgtc ctacctaact aattaattta ttttggtcaa 1140 ctaaaccttt agttacacca ggaaggcttg cagtattaaa cttaattcct aaatcaatca 1200 tttctttaat ttttgctttt tcatctttac ttagattaac tgaaggtgta attcttanca 1260 cgnatcttct cttgtatgaa cattaccaat atttatttct tcaattggta attttcctaa 1320 agctaattta taaacatcat cgnatacttt taacaacaat gtaaattaat tgtcaatcag 1380 cagctttagg tcaaatttct attaatttat caactgaata aaagctacat ctaacccctt 1940 ctggtacagt aactttcatt aattgttgtt gagtttccga aactgctgct tcatcgttag 1500 caacaataac tgagtttgat ccatttactt gcattcaaat agatgcttgt ccatgcatca 1560 atctttcatc aactctacat tgaacaattt ttgccataaa atctcccttt tatcaataag 160 gatttcaatc ctttttatat agtctcatta gtgcttcaaa gtaataataa tcacctcaaa 1680 tatttccttc atcaacacct ttttttgaat gtcatgaata aactccatgc aataaaattg 1740 gtgttccagg ttcaattttt ttattgtgat atttattaat taaatttctt aaaattaaat 1800 gagctgattt ttcgtataaa tctgttttat agtctttttg agtaatttta agcatttcta 1860 aaataccaca aactgctata gcactagctg atgagtcgcg tgattgatct gccttttcat 1920 taaaaattaa atctcagtaa caaacataat catcttgagg caaattattt aaaaattgat 1980 ttaacacttt ttgataaatt tgataagcgt ttttatctat ttttgaatta ttttttgcat 2040 attttaatgt aagtgwhanr mamhadatar agrahntwhn martndatns tathbcdcrz 2100 gtmsnwrman symbarahdd cbcwhnmart nwhnmartnh ddtbcbwhnm artnnrmawh 2160 nmartnmcrs twrdcdhccd bbcttdgdan abdaa*rtnt ry*atabwrd dcmntsmmar 2220 ynrmatndcm .ntsmmarynr matncmbmcr stwrddcmnt mswrddcwrd dcmnt 2275 <210> 26 <211> 1590 <212> DNA
<213> Stealth m rus <400> 26 gbbmnbcgaa ttcggccgtg tatatttcaa gcaacacggc catcgccaaa gtcgtgttca 60 ctacctgtcg ttttgcctat ctcttggtga acagccatcc cataggccag ctcttggttc 120 ccccaatccc agaaaccggt tttacacaca ctcccgaaca ccacatttta caacaactgc 180 tgtcgccaga ataaaccacg ccaaacacac ataagtatgt aattgtcttt tttattgagg 290 ggtggtggaa gcggggtttt ttaaatggca gcgtgcgtcg tagatgacct ctttcgctta 300 ggcttcgcgg gagccgctgg aggagctcgg acctgttctt cgatagcagg caactcatta 360 tcaggaacat gagggatcat tgacaacacc tcatcctcca aaacgtcccc attggccgcc 420 acctcatcca cagcagtggc accagccgcg tccaaaattg aggtgctttg atcgcaatcc 980 atgtccacca aacccataac tttctgaact tcacacaggg ccacttggtc cgtagaaaac 540 ttattcagca acacctccag agtgtcgtcc tcagacatgg caaactcgcc caccaccagt 600 ttcaagatca taacgtccag agcctgcata atccgctgcg acttctgatt ctccacctcg 6E7 gcggcggggc gcgtgtgcgg ctggcaatta tccgacaaga agtcctgcag cagacgacat 72) ttcatctggc actgccgata cagagggatc agcttgagca gatgcttcgt cacttcctga 7E:~
tccttcgcaa aagtcttaag atcctcgggc gtgatcccta acgtgctgaa gttttcctcg 89~

aagaagcagt gcatctcctg catgttcata tcctcgctag gctgcaacag cacatagtcc 900 gcactctgcg agactcgacg ctgacaggtg aaaactccac ataggcgccg tgccaggtcc 960 atcctccacc ggcaatgacg ctagttctgt tcgcgacaga gtatgattct gctcatatag 1020 tcgccaacgt actgtccaag tctgcatccg agcactgtgt gtttccctta ctggtgaaac 1080 accacgcctc caacctcatc tacttctgtt tgcagaccca aaaatgcacg gattcgcagc 1140 gcgtctctcc ggtattcgtc gtcaacaacg acgttttgaa tctcgcccac tacttgcaca 1200 cccgacagcc cattccgctg tcggccctgg tggacagcct caacgaagac gaaacgcggc 1260 ccatctacaa ccacttattc cgcaccgtta tctctcccga gcacggcggg gaggtgcgcg 1320 aattcwhanr mamhadatar agrahntwhn martndatns tathbcdchh gtmsnwrman 1380 symbarahdb cwhnmartnw hnmartnhdd tbcbwhnmar tnnrmawhnm artnmcrstw 1940 rddhccdbbc ttdgdanabd aartntry"t abwrddcmnt smmarynrma tndcmntsmm 1500 arynrmatnc mbmcrstwrd dcmntmswrd dcwrddcmnt 1540 <210> 27 <211> 1075 <212> DNA
<213> Stealth virus <900> 27 gbbmnkbcga attcctggaa gtcgattgga ttgtcagcat gcgcgccacc attgatgatg 60 ttcatcattg gaactggcag aacatgggcg ttgacgccgc caacatagcg gtagagtgga 120 aggccggttg cctgtgcggc agccttggcg acagcaagcg aaacgccgag aattgcatta 180 gcgccgagat tgcccttgtt tggcgtacca tcgagatcaa tcagtgtctg atcgatcagc 240 agctggcttt cagcatcgat accggcgatt gcgtcgaaga ttttgccatt gaccgcttca 300 acagcctttt caacgccctt accgagataa cggctgccgc cgtcgcgcag ttcgacagct 360 tcgtgcgcgc cagtcgatgc gcccgatggc acagcagcgc ggccaaaaga gccgtcttca 920 agcactacgt caacttcgac ggtcgggttt ccgcggctat cgagaatctc gcggccaacg 480 atgtcgatga ttgcagtcat aggagcaggt ccttcccagt agattgcctc gctctttgtc 540 gagacacatt gaagaaatcc gatttcacat cttcattata gaaataagag gcagaggaaa 600 atcccccgcc tgtggaattc ctgcaagccc ggggggatcc acttagttcn taganacggg 660 ccggcaaccg cgggtnggaa acttccagct ttttggttcc cttttanntg aaggggttaa 720 attggcgccg cnttgggcgg taaatcantg ggnccattag cttgggtttn cctggggtgg 780 naaaattggg tanttccggt ttcaccaaat ttccncwhan rmamhadata ragrahntbw 890 hnmartndat nstathbcdc gtmsnwrman symbarahmb cwhnmartnw hnmartnhdd 900 tbcbwhnmar tnnrmawhnm artnmcrstw rdsmdhccdb mbcttdgdan abdaartntr 960 ywkdtabwrd dcmntsmmar ynrmatndcm ntsmmarynr matndatdcm btathbcdcd 1020 mwnstathbc dcdatnstat hbcdcccmcr stwrddcmnt mswrddcwrd dcmnt 1075 <210> 28 <211> 896 <212> DNA
<213> Stealth m rus <900> 28 gtbbtmnbcg aattcctgga agtcgattgg attgtcagca tgcgcgccac cattgatgat 60 gttcatcatt ggaactggca gaacatgggc gttgacgccg ccaacatagc ggtagagtgg 120 aaggccggtt gcctgtgcgg cagccttggc gacagcaagc gaaacgccga gaattgcatt 180 agcgccgaga ttgcccttgt ttggcgtacc atcgagatca atcagtgtct gatcgatcag 29~

cagctggctt tcagcatcga taccggcgat tgcgtcgaag attttgccat tgaccgcttc 300 aacagccttt tcaacgccct taccgagata acggctgccg ccgtcgcgca gttcgacagc 360 ttcgtgcgcg ccagtcgatg cgcccgatgg cacagcagcg cggccaaaag agccgtcttc 420 aagcactacg tcaacttcga cggtcgggtt tccgcggcta tcgagaatct cgcggccaac 480 gatgtcgatg attgcagtca taggagcagg tccttcccag tagattgcct cgctctttgt 540 cgagacacat tgaagaaatc cgatttcaca tcttcattat agaaataaga ggcagaggaa 600 aatcccccgc ctgtgaattc twhattnrma mhadatarag rahntttttv whnmartnda 660 tnstathbcd csssstgtms nwrmansymb arahbcwhnm artnwhnmar tnhddtbcbw 720 hnmartnnrm awhnmartnm crstwrdmmd hccdbbcttd gdanabdaar tntrytabwr 780 ddcmntsmma rynrmatndc mntsmmaryn rmatncmbmc rstwrddcmn tmswrddcwr 840 ddcmnt 846 <210> 29 <211> 5331 <212> DNA
<213> Stealth W rus <400> 29 gbbsnbcgaa ttcgggttca tctgggcggg acgaacatta tagaagccct ctggtgcctg 60 acgatcaccc tctacgaatt tcggcccaag cttgccagac catttgcaga tttcataaga 120 agcaatctgg tcgtatttgc cgttgttctt ctgcttccag acttcgagga cgccttcttc 180 cttgaaaata cgaaccatca ccggcgaagt gcgcgtcatg cccttcgttt tcatcttggc 240 gacgattttt tcggaaagag gtttttcagc gcgtaagctg agatcggaaa cggacgagcc 300 ttgacagccc gcaagcagag cggatgccaa gagtgttcca agaagtgcgg ttctgatctt 360 catatcgcat cgagcctgtc agagcatttc cagcaaaagt gcgaagcgat tttgcatcgg 920 ataatgcgta aaaacaaata ggtagagcaa cgagtactca gctttaatca gagcctgccc 480 gaagccgcgt cttctgacgc atttgagcaa acctgacttt tcggtgcccg gatattaaca 590 actaaacctt tcagtatcgt tgataaaccg ttgctcaatt acctaaaaaa caccgtgtcc 600 gcaatatggc ggaaatgacg gcatgatgca aatccggcgc acatagtggt ctaattctga 660 catttgcttg ccagtgatac ggacgctgag caaatgtcgg aattatcaag atcactcaaa 720 tgcttaagtt tctagtggag tgaatttgac gtttgaaaca gcatttatgt cagtcgggat 780 tcaaacgtca aattcactcc actagagcgc cgtgcgcctt cttgggcgca caaaggtcgc 840 tctaacgctt tatatttaca gcttaatttt accttaaact gatgcaagtc taaggaatta 900 tgctgtagtg gcgcgccgga gccaaaaacc agttttatag taaattaaag gttacgaccg 960 atatcgagga acttctggcg gcgttcctgc ttcagcgtct cgccatcaac atccttcatc 100 gaacgcagtg aggcggtaat aatgtcgcct gcagcttcaa tcgtggattc cttgccgcga 1080 tgtgcgccgc cgagcggttc cgggatgatg ccatcgatga ctttgagatc gaacagatcc 1140 tgcgcagtga tgcgcatgtt ggaggcggcg tccttcgcac gagtggaatc gtgccacagg 1200 atcgaagctg caccttctgg cgaaatcacc gaatagatcg aatgttcgag catgtagacg 1260 cggtttgcga cagcaatcgc gatcgcgccg cctgaaccac cttcaccgat gatgatggag 1320 atgacaggca cgcgcagctt gaggcattct gcggtggagc gcgcaatggc ttctgcctgg 1380 ccgcgttctt ctgcacttac gcctggataa gcgcctgctg tatcaacgaa agtaatcaac 1990 ggcagctgga aacggtcagc catttccatg atgcggacgg ctttgcggta gccttcagga 1500 cgggccgagc cgaaattgtg cttgaggcgc gtcttggtgt ccgagccttt ttcctgaccg 1560 agaatggcaa caggctgacc attgaagcgg gcaaagccgc cctgaatggc ttcgtcgtta 1620 gcaaactggc ggtcgccggc aagcggcgtg aactcagtga acagccggtt gatatattca 1680 aggcaatgcg gacgatccgg atggcgggcg atctgtgcct tctgccatgg cgtcagcttq 1740 cgatagatat ctttgagcgc atcggccgat cgtttctcga gacggctgat ctcgtcactc 1800 atctcgacgc tgccctgttc ctgtgcgagc tttttcagct ctaggatctg gccttcgagg 1860 tctgcgacgg gtttttcaaa atcgagatag ttatacatcg ggcctgacta ttgtgcgttt 1920 ccagagatgt tggccataga acaagcccaa tagaggctgt tttacgacgc cttacatatt 1980 tacttcgcgc gcatcttgca aatttttctg aaattctctt acccgccgcg cgcttaatcg 2040 gcaagcggat gatgttcact taccagctta tgcagtcttt cttccagaac atgtgtgtag 2100 atctgggtcg ttgaaatgtc cgcatgacca agtaattgct gcactgtcct gaggtctgcg 2160 ccattctgta aaaggtggct ggcaaaggcg tgacgcagca catgcggcga gatggatgcg 2220 ctcgaaagcc cggcgcgggc agcaagactt ttgagttcac gaccgaaaac ctgtcgcgcc 2280 agatggccgc tttcagagaa agccggaaac agccacgggt tatcgtcgta gcccggcagg 2340 gaatcgcgca atgaaagaaa gacctgcaaa gcttcgcgcg ctttttgcga caggggcacc 2400 atgcgatcct tggacccttt gccgcgcaca atcagaaagc gatggtcggt gcgggcgaca 2460 ctgacgggca ggccaacaag ctccgaaaca cgtaatcctg tggcgtaaag cgtttcaagc 2520 agcgcgtgaa ggcgaagcgc tttgatacgg tctgctggct caagcgcctc ttttgcctca 2580 aggtcggcgc gatcaaggag gcgaccgaca ttttcaacgc tcatgatttt cggcagcggc 2640 ttctgttttt tgggtgcatc gataacgccg gtcggatcgt cctgcctgta gccttctgaa 2700 tagagaaagc gaaagaattg tctgattgtt gaaaggcggc gcgcctgcga tgtcgcagca 2760 aagccttcat tggccatgcc atcaagcaca tggcgtatat cgtcggtttt cgcctcagtc 280 atattgatgc cgcgtgcggt catgacgtcg gctgcagatt ccagatcgcg gcgataggat 2880 tcaagcgtgt tgtgcgcggc cccgcgttcg gcgctcatca tttcgagaaa attctcaatc 2990 gccaaagatg cccgcatgtc tactcctgct tgtccgccgc gtcgggccca tcggtctggc 3000 cgtctgtgac ggtttctgac ggcatcgttg ccggtgccga cgccggaggt ggggcaacga 3060 ctgtttgctt cagttttgac gccgggattt cgacggtgat ctcatgcgtg acgggcttca 3120 cgaaattggc gagcgagaac attgcgccgt agacaatggc agcgatcaca gcaagcagga 3180 caagaatgcg cgtcagcgtg ggcatggtgc gtttatgctg tgctattgag acgaaagcaa 3240 ggacagccaa agcgcgtgca taaaaagccc tatttggtgc cgttcaggcg atgaaagcga 3300 ttgacgccgc gcggtttttc atgtggaacc ggaggaaatg gatgaggttt atgagcagta 3360 caacaaaaca gacaaatctt aacgagaagg cggacactgt ccgtcagctt cttggtgcga 3420 aagtggttgt tcttgttggg ctgatgggcg caggcaagtc gacagtcggt cgcaaggtcg 3980 caacaatgct cggcctgcct ttccgcgatg ccgataacga gattgaatct gccgcccgca 3540 tgacggtacc ggaactgttt gaagcttatg gcgaagctga gtttcgtgat ctggagcgca 3600 gggttatcct gcggcttctt gaggatggtc cgatggtgct cgcaaccggt ggcggcgctt 3660 acatgaatgc tgaaactcgt gaggcaattg ccgcaaatgg tgtttctgtc tggttgaatg 3720 cggaactgga tgtgctgatg gaccgcgtgt ctcgccgcca aaaccgtccg cttctcagga 3780 atgatgatcc gcgcggtgtg atgcggcggc tgatgaatga gcgctatccg gtttacgcgc 3890 tcgccgatct gcatgtgatg acgcgtgatg acaagaaaga agtgatcgcc ggagaactga 3900 ttgacgttct ggccgagtat ctggccgagc atctggataa gaagtaagtt tagactgctt 3960 tggagtggat tatgactgct gccgatactg ttacggttcc cgtctcgctg ggcgaccgat 4020 cctatgagat cctgatcggc aaaggtctta ttgcccgtgc aggcgaagaa gttgcaaagc 4080 gacttccagg cattcgtgtg gcaattgtca ccgacgagaa tgttgcaaag gcacatcttg 4140 aagcactgac cgacagtttt gcgcgcgctg gcattcaatc cacgcccgtt atcgtgacac 9200 ccggtgaaaa atcgaaatct ttctcgacac tcgaaaccgt aacaaatgcc gtacttgctg 4260 caaggcttga gcgtggcgac gcagtcgtgg cttttggcgg tggggtcgtt ggcgatcttt 9320 ccggctttgt cgcaggcatt gtgcgtcgag gcatgaattt cgtgcaggtg ccaacctcgc 4380 ttctagcaca agtggattcg tcggttggcg gcaagacagg catcaacacg caatatggca 9440 agaaccttgt tggtgttttc tatcagccgc agctggttct ggccgatacc gaagtgctcg 4500 atacgctgag cccgcgcgaa tttcgtgcag gctatgcgga agtggcaaaa tacggcctca 4560 ttgaccggcc ggatttcttc gcctggcttg agaaaaactg gcaggacatt tttgcgggcg 460 gtacggcacg cacagaggcg attgccgaat cctgccgctc aaaggccgca gtcgtggcac 4680 gtgatgaacg cgaaaccggc gaccgcgcac tgcttaatct cggtcacaca ttcggacatg 4740 cgcttgagac ggcgacaggc tacgattcaa gccgtctggt gcatggtgaa ggcgttgcca 9800 tcggcatggc tttggcgcat cgtttctcgg tcaagatgaa cctttgtggt attgaagatg 4860 cggaacgtgt ggaagcgcat ctgaaggccg tcggtcttcc gatttcgctc aatgatgtgc 4920 cgggcggttt gccggatgct gaaaagctga tggattacat tgcgcaggat aagaaagtag 4980 cgcgcggcgc gctcaccttc attctgacgc gcggtattgg ccaatccttc atagccaagg 5040 atgtgccacc tgcggctgtg cttgaattcw ha*ywvtsrn rmamhadata ragrahntcw 5100 hnmartndat nstathbcdc hgtmsnwrma nsymbaraha bcwhnmartn whnmartnhd 5160 dtbcbwhnma rtnnrmawhn martnmcrst wrddgkdhcc dbabcttdgd anabdaa*rt 5220 ntrywvtabw ttwwrddcmn twdatnstab smmarynrma tndcmntsmm arynrmatnc 5280 mbcatnatns tathstathb cdcmcrstwr ddcmntmswr ddcwrddcmn t 5331 <210> 30 <211> 552 <212> DNA
<213> Stealth virus <400> 30 gbbmnbcgaa ttcgttgaaa atcttgaaaa acatgaaaac agaattttaa atcaccctgg 60 nnttgnnnct ttngnntttt tttgggtttn aanagatttt ttannatnnn aaagggtttt 120 tttagggtnt tnaattttaa ggggggnnat ttnnagaagt tgntgatttg aaattaanat 180 tgtacaaaag tcaaaacatt gcattattag gatcaaatgg agctggtaaa accacaacag 240 ttgaaatgct tgttggtatt cttaaaccaa gtgcaggaaa tattaaatac ttttttggcg 300 actcaatgga taaaggaaaa attgatgcaa caaaaattgw wnrmamhada taragrahnt 360 whnmartnda tnstathbcd cgtmsnwrma nsymbarahb bcwhnmartn whnmartnhd,420 dtbcbwhnma rtnnrmawhn martnmcrst wrdbdhccdb bcttdgdanb cddaartntr 480 ytabwrddcm ntsmmarynr matndcmnts mmarynrmat ncmbmcrstw rddcmntmsw 540 rddcwrddcm nt 552 <210> 31 <211> 386 <212> DNA
<213> Stealth virus <400> 31 gbbmnbcgaa ttcaacacca acggctctcg cacgcttgca accgtcgttg ctgagccgct,60 ggaacgcggt tttggtctga cgcttggtaa cgcactgcgt cgcgtgcttc tgtcgtcgct 120 gcgcggcgct gccgtgaccg ccattcagat tgatggcgtt ctgcatgaat tcwwnrmamh 180 adataragra hntwhnmart ndatnstath bcdcgtmsnw rmansymbar ahbcwhnmar 290 tnwhnmartn hddtbcbwhn martnnrmaw hnmartnmcr stwrdrrdhc cdbbcttdgd 300 anbcddaart ntryctabwr ddcmntsmma rynrmatndc mntsmmaryn rmatncmbmc 360 rstwrddcmn tmswrddcwr ddcmnt 386 <210> 32 <211> 1643 <212> DNA
<213> Stealth virus <4ao> 32 gbbc****** nnnmbctcga ggtcgacggt atcgataatc ttgatactaa attgatttca 60 ttcattttaa ttgcttctaa ttctaagttt atttttgaaa tataagctat cttttttatg 120 tctgtttcat agtcattatt attaacttta tttcatcttt taatagcatg gtctgaaacc 180 ataatatcaa aagtttctat tgctttatct cttatttctc taaagaattt tgcataaaca 240 tcatgcttat atcatctttt aatttcattt aattcttctt ttgctaaatt ttttgaaccg 300 cctggattat attccattgc atattcttct aatttattaa ttggtaaagg atcaaaagct 360 ggaatatagt ctttaggaac taaattaatt ttagcaattt catttggttt gaatgtttcc 420 atgataactt ggtagtcaca attatctaag gttaaagttt cttctttaac aattacatca 480 aagtaaataa atgctccata tttcttttct aattcaattt tttgttgaac aatttcatta 590 aatttttcat ttaaaactgt tttgccactt agagcaatta gcataggttt tgaaattggt 600 tttgagtgtt taatttgttc attcgttgtt aatttaattc aatcaaattg aggataattt 660 ttatccaaag ttgtaatact tgattttact aaagctttca tattaactcc ttttataatt 720 aactcaattt cttattaaat atagcataaa acaatggttt tggtaaaaaa ttaatttgtt 780 taattcaaat attttttaac atttttatat gactttctat gaaattcaca gatgccatat 890 tga~ctcattg ctgcttcatg ttcttttgta caatagccct tatttttctt gaaattatac 900 ataggaaatt ttttgtcaat tccaaccata attaagtccc tagttacttt agctaaaatt 960 gaagctgctg ccacattaat acttaattgg tcacctttta ctaaattaat ttgaggtata 1020 ttgatgtcat taattttttc aaaatctgta attactaatt caggttttgt attaagttta 1080 ttaatacacc tttgcatgcc aattcttgaa gcttgctttg gatttagttg atctacttct 1190 tgagcattaa taatagttgt tactgtttca atagcatttt caagaataat ttctaacgct 1200 tcctcacgtt gtttttgact caattgttta gaatccttta ttaaaggatg gttaaaattt 1260 tgaggcataa taacacaacc aactactaaa ggccctgcac aacaacctct tcctgcttca 130 tctaagccta caattaattt agtgtcagga taattttctt tttcataatt caacataatc 1380 aaaattatac aaaaaaagca aaacttgaat tcwhanrmam hadataragr ahntwhnmar 1940 tndatnstat hbcdcgtmsn wrmansymba rahhbcwhnm artnwhnmar tnhddtbcbw 1500 hnmartnnrm awhnmartnm crstwrdnnh dhccdbbctt dgdanbccdd aartntryda 1560 tnstathdkn m*tabwrddc mntsmmaryn rmatndcmnt smmarynrma tncmbmcrst 1620 wrddcmntms wrddcwrddc mnt 1643 <210> 33 <211> 1033 <212> DNA
<213> Stealth virus <400> 33 grbbrmnkbt gaattcaaga acgattacaa cagattagac agcggatgaa acaggtgaca 60 gaggatgtca cccaattgag tgagtactca aaaacccatc ccttggcagt tgaggtggtt 120 aaatccttac gaaagactac ccgaacacta aaaaacctcg aagagcgatt actaacaatc 180 ttggatcagg cccaaaagtc taatcgaatc attataaact cgctgaagcg catagaaaaa 240 acgtgcatgg ctctgagcac gaaaaatctg caggatcacg gcatgcggta ctgcattgcc 300 gaagcccgag gcctactccg cacacatcaa gggatttctg ccatccctcc ttcggctatc 360 gaccacctgc cgagtaacgc ggagtccaag ctacgcaact tcctcaaaac gtttcgcgaa 420 scgccgtgga acatagcgaa ctccagatga gcgccgttac ggataggcag caacagatta 480 ctgttcccga agtgttgaca aaccgctacg caccctcgaa tcagacaaac gacatattaa 540 actggtatat tatgtcaaaa gaccaggcgc agatgaacat cttgagttcg attcacccag 600 aagcccggta tgcgtgatct ccccgccatc ctaaaacatg aaaatctatc aagcacgtta 66~) cgatcaaacc cacagccgat ttggcccacg ggcgggaagt caatgtgtct gcaactgttt 72~~

*rB

tatgtacata cacgcccttc acctgaaagt gcngcacacg acgctcggta ctgacaccta 780 gatgagatat tgacgaagag cgcattrwha rrnrmamhad ataragrahn trrrrtwhnm 890 artndatnst athbtdcmbr gtmsnwzman symbarahmr btwhnmartn whnmartnhd 900 dtbtbwhnma rtnnrmawhn martnmcrst wrdmdhccdb rbtttdgdan bcdaartntr 950 ytabwrddcm ntsmmarynr matndcmnts mmarynrmat ncmb*mcrst wrddcmntms 1020 wrddcwrddc mnt 1033 <210> 34 <211> 1076 <212> DNA
<213> Stealth virus <900> 34 gwbbw*r*** **btgaattc gctgcgtcag cacgcacttc aaaaaaaatc cagcgacgat 60 agccttggca gtatgagggg aagagccccc ccagaagacg attgancgct aaaaacgagg 120 gaaaggcccg tagtatacgg cgatnaatgt ctatgngctt tttttgtccg tntngcttgc 180 gaaaattgng taagncgccc anagaggtga taaccccgct tctcaacgac atgacgcgta 240 tttcattgca gggaaatngn gactcgacgc gacctgntcg tgaattgcgt catattaaat 300 aggccaganc acatnttgga acccgtcccg gtttcatctg tccatctgat gccgaggcct 360 gctatggcac gaggcctaat actgggctgt gcgctgacat ggctcatatt gaaaacaacg 420 gcatcttcaa tacaatatcc agatatagta ttggagctta cccgtcgacc ccttaaattt 480 ttacaagaca attccacaaa atgcgacaac aacggtaccg cacgaaacat cagtacagtc 540 aaagaaaacg ccataagctt caatttttac aacanaaaag acgactacac ccgtcttcca 600 gttacctcga tgccttttca ccggtacctt agcaggaaag cttttttaaa accaagtggg 660 atctgtccaa agnaaacttg gaagactacc ttcaaaacaa cttaaacgtc ttacgctaca ?20 agttcttctt caaggataaa ctttccaatt accaaatact tacnggacca aaaancctna 780 actggaacca aaaaaaaacc ttaaaaagga tcaggcccnt tccattcatt acccccwycw 840 wnrmamhada taragrahnt whwwwwhnma rtndatnsta thbtdcvvvv wgtmsnwrma 900 nsymbarahb twhnmartnw hnmartnhhh btbwhnmart nnrmawhnma rtnmcrstwr 960 drdhccdbtt tdgdanabda artntrygta bhwrddcmnt hwwsmmaryn rmatnttwdc 1020 mntsmmaryn rmatnhhdat nstabcmbmc rstwrddcmn tmswrddcwr ddcmnt 1076 <210> 35 <211> 1102 <212> DNA
<213> Stealth virus <400> 35 gbbmnbtgaa ttcgtacaat ctcacccaag agttgtcgtt agtggaggac gctcggtttt 60 gccagacgcg gcccgtgaac gccgagcgcg ttcgcggtgt cttcggcgcg ctctatcgcg 120 ccgcgtcccc gcacatgcgg gaggagagtg accgcatcaa gctgattttg ggacgcttgt 180 tgctgggacc cgtggccgtg ccctgctact gtgacgaatg ggaggcgaat gactacatgg 290 tggaggcggc gcagttttgc accggccccc tgctgtatgt gcaccgacgc tgccactgtc 300 ccggtatggg gcgcgcgctc gctttcaccg tgatggaagg gcatgtcgcg acgcatgttt 360 ttagagggct gctgtcactc actgagtgga accagcacct gcccgacatg ttttgcccgt 420 gcggcacggt gagcaggcgg gatcggtaca gcatggcctg tctgccgcgc gatcttacgt 980 tttatatcag cgattatcct tactttatgg tggagatcgg gcgtgtgctc accgtgagtg 540 aggtggatga ctacgtgagt cttatgacca gctacttggg cgacgccgtg accccttgcc 600 tgcaagtgca ttacaaactg ttgtttgggg tcaatgtcag gcctttaagc cccgctggcc 660 cttgagtttc aacgtgccga attttttatt ttgggaactt tcagaaaaat gtggcttagg 720 gggtggaagt accacaaacc naggtgaccn gcnggatttt tttttgggac ncgtttttac 780 ccggaacttg gnncaaggga atccgggggc nacccnttca ttgaatggnn ttttggngcc 890 ctgccccwha nrmamhadat aragrahntw hnmartndat nstathbtdc mgtmsnwrma 900 nsymbarahb twhnmartnw hnmartnhdd tbtbwhnmar tnnrmawhnm artnmcrstw 960 rdtdhccdbb tttdgdanbb ccdaartntr ywstabwrdd cmntsmmary nrmatndcmn 1020 tsmmarynrm atndatdcmb tathbtdcdm wnstathbtd cdatnstath btdcmcrstw 1080 rddcmntmsw rddcwrddcm nt 1102 <210> 36 <211> 8691 <212> DNA
<213> stealth virus <400> 36 ccdbasschc ksmgaattcc tcaggctctt tcttaatctg ggatgctggg atcatggtgg 60 acgtgggagg cacgggtggt ttaataatga tcttggtagg gcagtctgtc ttccgggatt 120 tcttacgtgg gatgaacagg gtttcaggat tgcaaacagg tggtggcatg ggctgactct 180 ctgactgagt aacagcgcca tggggggtgc tgggagcagt ggtggtggtg aggatggatg 240 gggtggtgat ggtgatacct gctgagctat ggtcaatacc agcttgattg acagcctgag 300 ccagaatgtc actgtcacta gcaccaccta agttaaagaa gacacggggg cacttagtgt 360 tttgaacatg gtcacattta ttgagatcca cagcacaagt acaggacaac atcttcccaa 420 ccaaccaagt cccacacaat aatgagtcat acaccaagta catagtgttc atgattatat 980 attgtatatc atagagtata acatagagta tatatatggt ataatatcat acattagtac 590 agttagacaa tggcataggg ggttacaata tattagtaca tcatcaatag atgcaattct 600 aactgtctgg ctatatgggg ttacaatggc agagttatag ggaccagccc atataactgt 660 ctatctgaat gacttactct ggcttatcag tcttgctcct ggtcatcata gggtgagagc 720 tcttggaacc ttccccatca tccccctctt tcttaatctt tccagccctt aggacagtgc 780 caaccacctc ctcttctatc tctgtctcat catcagaatc ctctgctttc tcaccctcag 890 tctcagcctg agtctctccc tgctctgtct caggtatcac catctcactc tctccctgag 900 tctcagcctc aacctgtccc tcttctgcct gagtctcctg ttcctctgct gtctcagtct 960 cttcctctgc ctcactctct tcctcctctg tgtcagagaa aagtaccaca kaatgcagag 1020 ggatgtctgg acttggcaca ttctctggga gcacaccacc agtcacaggt gcatagctag 1080 cctctctctc attttcaatg atgatttccc tgagctcagc catgctccat gactttatct 1140 tatcagtctt ttcaatgcac atcttaaggt acatgtcttt gaccaggtac tgtatcttgg 1200 gtattataag tttcacaatg tcctctgtgg gtaggtgaga ctttgagaac attgtctggg 1260 cagtctcatc acagatgtaa gtagagagac tgttcataat gatagacatc tgctggatgg 1320 gtatatacat gcccaacatt atctcatcat tcttagagtt accttcctta tagaaggcat 1380 tcatggtgtt aaccagcagt gtctcaaatt tggaattttc aatctgaagg tctgtctgct 1440 caccatccag tatcttaatg atgttcagac catagttaat catggtctct ggatcatcat 1500 ggtgaggcag acttctcagg aagatgagtc cctgtgatat gccctgactc atcttaggag 1560 tggtgacaca gttacaagtc atcactgagt atttaaagtg tgtgtatgtt attctgtcct 1620 ggaggtcttt ctgttttatc ttaaccttgt cacttaaggc tgtctcaaac atcttggtca 1680 tcttaactgt ctcatcagct agcttcttaa cacactctag atattgaccc tgcagcacag 1790 gaggcagctg gtaattacag cacatatcct caagggtctg taagataccc ttcccaccca 1800 ggaaaggttc catcactttg cccaggagag caatgctatt gttaacccca tcctgtaact 1860 gcttaaactt cccctccatg cccattctta tgtcattgag ttgctgcagg tgttggtttt 190 tgatgtctgt gtggtttctg gcaattctga gcttggtctg atacactgtg aagagataaa 1980 ataatataag tatatgtggt ttggtgtatg tggtgcagta taaaaaagac acaacacaca 2040 gtatacttac caatagtttg cacttttctt aagggatccc ctggatcttc atttatgatc 2100 tcctccaggg tcttaaagga ctcatcatca ggcacttctg caaagcccaa cagggggtct 2160 cctaggctca ggatacccct tgtctcttct tccaacagct tctcaaggaa ctgcacagct 2220 ctttcagtgc caggatcctc atgtctatgg gttaacataa agacatgtga gactggggcc 2280 ccatacacac agagttggca cacagtgtta acaaagtctt tattgatatg tatgtgaagt 2390 gttgcattga caacctacct gggcatctta ggtggagatg gtccaggttc aggtccagca 2400 gaggttccct cgccagggtc cccttcagtg tgttgtgggg gctggtcatc agcctttctc 2460 ttggtctgtc tggggtccat ctttacaggt tgcttgctct aaccactgga acatgaaaga 2520 cagactcagt atctgctgcc tctgcctaag cctggtggcc cacctcaatc aggctacccg 2580 ggggactttg agtgaagaca ataacaacat caatgggatt gggcccctta cctcctctgc 2640 tatggggctg aatactcagc cacccgggtc tgtgatggcc ctggctgtac acactgcatc 2700 atcatctcct tcctcgacgg tattacccac ggtgctggca ttaagtggca tggtgctggt 2760 ggtgttattg atgattggac taaacattag ctcaaccttc tggagccaag aggtggatga 2820 ggacgcactg gacacggyca ccacccccgt agaggtctat acsgtggact tatgtgttaa 2880 aacagtctaa aaataaatcc tgwggatgaa ataacgtgtc tgtacatgct taagaactac 2940 ttggcacaat gccaagactc catatactgg cggacagcca gttggcatag ggccagatac 3000 tggagggttg ccaagtgcac cgtcaccaat tggcatgggg ccatgatagc gtcaccagcg 3060 ggcatagggc cagaaagcac cgtcaccatg tggcataggg ccaagctata gataagcagc 3120 gtcaccaata ggggcgtggc tataggaaac accgtcaccg atagggggct gcacccataa 3180 gcaatagctc caccccctta tcaatagcac cgcccattag cattagcgcc tcccataatg 3240 gggctggctc atgtacgtcc agccccctat atatagcatg catatacatt agtaccgccc 3300 accgccatat atagattcta taggccaatg gggggcgtgg caatatggcc gccgtccgcc 3360 atattggctt cctatagatt ctatagcatc cccattgact tacattagtt ggcaagctca 3920 atccgcattc caatgcaccg tccccggcta tggaggctgg atcggtcccg gtctcttcca 3480 atggagctcc tccggcgtcc ccaggcagaa tggcggttcc ctaaacgagc attgcttata 3540 tagacctccc atcaggcacg cctaccgccc attgacgtca atggcacgcc catttgcgtc 3600 attgctcccc ccattgacgt caatggggat gtacttggca gccatcgcgg gccatttacc 3660 gccattgacg tcaatgggag tactgccaat gtaccctggc gtacttccaa tagtaatgta 3720 cttgccaagt tactattaat agatattgat gtactgccaa gtgggccatt taccgtcatt 3780 gacgtcaata ggggggcgtg agaacggata tgaatgggca atgagccatt ccattgacgt 3890 caatggtggg tggtcctatt gacgtcaatg ggcattgagc caggcgggcc atttaccgta 3900 attgacgtca atgggggagg cgccatatac gtcaatagac ccgcccatat gacgtatata 3960 gtaaagacca tatatagata ctattgacgt caatggggga gtggctatgg gcggtattag 9020 gaaggtccat atatggtata tgggaccgcc ctattgggag gggctagtta cgtcaatagg 9080 aaaacccata tatggaatac tatatggcat agggccaata catagtattg aacctggcca 4140 atagccatat tggcataggg ccatattgga tattggctat acattgatca tggcatatag 4200 ccaatayacc ataytgaatt ggcacaggtc cagttcctcc atattgaatt ggctagggtc 4260 cagatccacc atattgaatt ggcacaaatc catatgcgcc atattgaatt ggcacgagtc 4320 catatgcgcc atattgaatt ggcacagatc catgtgcgcc atgttgaatt ggccagtgtc 4380 caaatgcgcc attttgtttt ggcagaaatc cagatccacc attttgattt ggacccattc 9440 caagtccgcc atattgaatg ggctcgatgc caagtcgcca tttgcaattg gcaccatgcc 4500 ggataatttt ggcacagtgc cagatccgcc atctttgctg gcaccgtgcc aagtcgccat 4560 tttgaatttg gcacgttgcc aagttttttt ggctcggtgc caaatccgga ttttcttggc 4620 gccgtgccaa aatcgggatt ttgcgttttt tggaatcccc gaccccgggg ggactgtttc 9680 cacgtggttt ggggtctcta cgaggctccg ttcgccgggt atccgggggg gtattttctg 97x0 aaaaataagt tggcattttg ccaagttttg gactcgaaaa taggccgttt ttcaccatct 9800 gagcgacccg ttttgacggt caaaacggcg tgaaaaatca ccgtttttta cccgtttgaa 4860 ctggctattt ttttgcattt tacagccctt tttaccaccc attttttacc cgtttggaac 4920 ctatttttta ccctctctcg gacccatttc ggactcattt ttgggcccat ttcttgttca 4980 atttttgacc cacctggggg gtatttttgc gctattacgg accccatttt tggtccattt 5040 ttcacatgaa attgggtcca ttttttgctc gtccgagacc ccatttttgg ctcatctgaa 5100 gcccattttt gacccgttcg aaaccctatt ttggttccat gaaataccaa atttttagcc 5160 cacttagacc cattttttag tccacatcag accctaattt tgacccattg aacactcatt 5220 tttggaccat tccgaacctt gaatttggtc caagttctac ccttttttgg ccccattcca 5280 acgttaaatt tcatcccatt ttccgccgtt tttggccact gtccaacccc ttataggacc 5340 cactttcagg cctcttgacg acacatttct aaccccattt tcctccacat caaggcccat 5900 tttctaccca ttttctaccc aatttcaagc ctctttggaa cccaatgaaa ccccgtttta 5460 ctcccataaa acacactcgc atacaggcta attctccaag tttattccgg tctaattagt 5520 gcaacaaaca agcagctcgc gtgtatggtt cgcggtatga aatgtgtaaa cgatttcttc 5580 tggttcggtt aagtttgaga tgctaggcac gtaggttaca ttcatatcag tcgagttggc 5640 agtggttgaa aaacctgaga tgttggttgt cggtggagaa ggagttcgta cagcggtatg 5700 gccaggggta ggcgttggag gtagtggagt taaagacttt agggttgaag gttttggagt 5760 tgtaaacagc gtcttgttgg cagtggcagc ggtattattt tgagttgcgt tcctcgcggt 5820 aatgcccgcc agaagtccat gggtcacagt ctcatttcgt ccgtactcca gagtcgtgtt 5880 cagaaaccag ttaaagtcca taaacggctt ctgtgctttt gccggctcaa cccagacata 5940 gtcaatttta tcagacgcgc ccaggatata ttttgtatta tcatagcgac tagcgcagcg 6000 taccgttcca ttggggcgga caaacagtct gcaaaaatag taacacacag aattgttacc 6060 actctgttaa acgttcataa tctgttctgt catattaata aacaaattac ttacgggttg 6120 taattgcagt ccgttaaggt tctgtgaatt ttttctctag ttaaattctt ggccaagggc 6180 atgatgacgc gttctgcatt tgatgcattt ggtggaaagc atatgtcccc aatgtcacag 6240 ctaagtctat ggagtaatta caaagtgtta taatctgttt catcctccaa atggtaaact 6300 tcttttttca gaaaaacaca agagctgata cgtacgagac tgtatggttg ctgcagatct 6360 tgaagttgtt gcagttgcta ggcgagtagt taacactgac catgtggcag cacgcaggtg 6420 ctatggtggt tgggcggtac tttgcgtagg ctgacgacag tactgaaata gcgcagacaa 6480 tgaagagcag attcatacta acttcaactg ggtattactt tcgaggaggc ttcgcggtaa 6540 tcttgggagc ttcttctccg gcgaaaaggt ttgggcggac gcagatggtg ttgggctttc 6600 tagttataga agttaattcg attctcactt ggaacgccaa ataaccagag gcccgcaccg 6660 cccaggtggt cactcgcatc tgacaggtct gtgcgtcggg accgtcttta acgcggtacc 6720 gaagagtctt gatgttcttt ggtatcatgt gagcaccaaa tatttctctg tcattatctg 6780 tgacattaat tattttggtg ggcgacgctg ccgcttccgt aaagcgttga aagacagcat 6840 ggtttcgacc actgcgaata attcaacaac gatcattaaa aagttattct cacaatgtat 6900 gcattgtgat atcacgctat ctcaacctga gatcttacct gaggtagtgc gccagtttcg 6960 tcacccatgg agagggccgt tcaatcagat gttgacccga cttcgtatgt aaaacgtaca 7020 gcgtactgtt tccgcatttc gggtttggtt tctcaatatc gtaagatcga aacagcccga 7080 agtcttgtgg aggagatggt tgcgcgggac agagtttatc caagtgcaga tctagaggag 7140 tcattaagcc aaagagcaga cacagaacgc agacgcacag ttgcatatag ggagtcattt 7200 cttttcgttc ggtaaactga tagatatgaa aaggtatcgt ttcgagtagc tgtgacctga 7260 attggcgttg aaggtaatga ggcttcgctg cacaccgctg gcgacaggtg ggagcttcaa 730 ggttgttttc aatgctccgt ttgtgtattg gatagtttcg aaaacttcct tcaggtcccc 7380 ctgcaggctt tttgcaatcc ctggcgctct attctgaaat gcgttcacca agagtgatac 7490 ctccgtgacg ttgattctga aatatataca gagtggtgat gaacacgcct attacaagcg 7500 caacgctgtc acatgtatta tgtaaaccca acgtacctct gtaacacgtc cacgccatcr 7560 cggccgtggc tcacatcata gtggtacagc agagtcgtgt taatgatccg tttcaaaaac 7620 tcgtttcgac gtgtctcacc gatgacattg gaacagagat cccagtaact atcctgcctg 7680 tgatgcggag tgaaattcgc atacaattcc gaacacaacc cgtgaaccgc ggtcgcgcaa 7740 cacaacacag agacacagat aaacacacac catgtaccca tgttgtgttc taaaaaagct 7800 ttattgacag aacgttattt atagctagtt gtcatattct ggctctttca acgtcacttc 7860 ttgggtgttt actttaatga ccttaggtat ctcccacgaa tccataggtt cgctcatggc ?920 ttggtaagcg agttcattat agatggacat gtagtaatgg atgttttctt catcatcggc 7980 tttggactcg atcatcatag gagagtgacg cccgtagttt gggttgacga gagagatgag 8040 gttccccttt ctatcgaagt acatgacgtt attatctgcg tcatcgtcgc tggtggagtc 8100 ggtttctgat tgtcgcaact gctgatactc gtggtttctg gtattggtct ttctttcgca 8160 agagcgccgc ttgtcttccc tgagcaatgt cacagcttct tctttatcac ccgagtaatg 8220 cgtcactaca ttgcgagagg agaacgtact atatagcgcg gccaccagga ccagaagtaa 8280 acagagaagc gctacggccg aggcgcagta gatgacgatg cccaacagtt cgcccagcac 8340 aatcgatgat gaggcagttg ttgctattgt agtcgagacg gttgcggtga cgttgccggt 8900 agtaacattt gtagatgtgg gtttcgttgt cgtcactgtg gtgttgttgc tgccggcggt 8460 agtcatttca g.cggtctgat acctcagggt ggtttataag cacccaggca cgtggttgcg 8520 ggaaggcagt tccacgtggg tattactgag tttgcggggg acgttttaga agtgcaccga 8580 gaacgaaaat gagcaccacg gtgatcacga aggggttgtt ccaaagctgc ttcaagaatt 8640 c 8641 <210> 37 <211> 1213 <212> DNA
<213> Stealth virus <400> 37 gtbbtgagct caggccatgt taacttgtta ctctcaccta aaacgtgtta gcatttacga 60 tcccctgaac attggtgtta actgttttga ttaaacactt gactctttgt acccgcgtgt 120 catgtgtggt gtatctgaga tgagggcccc gcaacatatt tagaggkgtg ggctcttcac 180 gaacgatcga gaactatgcg acttcgttcg gaagaaacgg agacggttcg ttccatcttt 240 ctattacgrg tttacattct catgtggatc gagggcatgc tcttkttgag cacgtgcgca 300 ctctgctggc tggtgttgcc agagcgcttt gtgcaccttt taccgagtat tcgtaggacg 360 ttattttgtt taatgctttc tattatctgg ttgggaatac ttcactgggc cgagcctcag 420 tttcccaggg agctgtacgt cttgttgact tacacgttca tcatggccgt ggcgatcacc 480 gcgtcggggt ttcaattcgg aaaccgctcg accgtctacg ccatgttggc tattatyttk 590 ctgtttathg ttctgaccct atccacgcat cgctttgccg gagacgtaga gttctacaga 600 ccgttgatag cggcctcgtc ckttctcatt ytagtcctcg caatcctttt ytactkcttt 660 cccgaagaga tcggagaaat tgcagtaatg attggmggtt taawagtctt ggtcacatcg 720 gtcatctgtg agactcaaga catkttacac cagwtagwtt acgtwagcta tgtcccgggt 780 gcgatktwtt tttacatcga catyatttth attnrmamha dataragrah ntttttvwhn 890 martndatns tathctdcss sstgtmsnwr mansymbara hrsagagctc aggccatgtt 900 aacttgttac tctcacctaa aacgtgttag catttacgat ccccwhnmar tnwhnmartn 960 hhtgagctca ggccatgtta acttgttact ctcacctaaa acgtgttagc atttacgatc 1020 cccgwhnmar tncnrmawhn martncmcrs twrdtcdhcc dtagagctca ggccatgtta 1080 acttgttact ctcacctaaa acgtgttagc atttacgatc cccttdgdan daadaartnt 1140 rytabwrddc mntsmmaryn rmatndcmnt smmarynrma tncmbmcrst wrddcmntms 1200 wrddcwrddc mnt 1213 <210> 38 <211> 1198 <212> DNA
<213> Stealth virus <400> 38 gbbg*kkgaa ttcgatcgga taccccgtct acgtgtatta atattacata aaataggctt 60 ttttttaaaa aaaagaaaag aacatttttc actaatggtg tcatatcatt ataataaacc 120 ttgttttcat caggaaggta taaaaacaaa ttcatatgca ctaaataata tagattcaaa 180 acaaataagg caaaaatcaa tggcaacaga ataagcatat atataaacat ggtgaaaaat 290 tacatataaa caccaagaat gtggaagatt tagctgtgat tagcaaattt tgcctaatgg 300 atatatatgt ataaacttgt cccaatatct acagagtact cattcctatc aaacacaaat 360 aaaacagttc ttaaaaattc agtacatatt gtgtcaattt taaaaataag cttcaaagtt 420 ttgatactat aatttagaaa ctatctcgag ggaaataata taaatagttt aaataaaagt 480 gaggtgaaac taatgtatat ttagatgaag cagttatagt tttaaattta catattataa 540 aagaagaata ttaatgaact aaacatacat cctaagaagt tagaaataga atagcaaaat 600 aaactcaaag aaagcataaa aaaagaaact ggtggaacgg gaaacacacg tagacggggt 660 atccgatcaa gcttmwmwnr machmhnhad ataragrahn ttntrrncwh nmartnmdmy 720 sskdcwhnma rtnmdaskdc whnmartnda tnstathskd chasrttwns hasrthasrt 780 cttrhasrtc ttrgtmsnwr mansymbara hyyagaattc gatcggatac cccgtctacg 890 tgtattaata ttacataaaa taggcttttt tttaaaaaaa agaaaagaac whnmartnmd 900 whnmartnhh tmgaattcga tcggataccc cgtctacgtg tattaatatt acataaaata 960 ggcttttttt taaaaaaaag aaaagaacaa atwhnmartn mdctanrmaw hnmartnmcr 1020 stwrdadhcc damgaattcg atcggatacc ccgtctacgt gtattaatat tacataaaat 1080 aggctttttt ttaaaaaaaa gaaaagaact tdgdancddb crtntrytab wrddcmntsm 1190 marynrmatn dcmntsmmar ynrmatncmb mcrstwrddc mntmswrddc wrddcmnt 1198 <210> 39 <211> 5643 <212> DNA
<213> Stealth virus <400> 39 bgbbnnnnnn rrrccgagct caccaaacgt tgcggagaca agtcggcgct cgggactcac 60 atccaccgac tcattgcgct cttggatcac gacaaccatc gcgaactgtg caatgtgctg 120 gtcggcctgc tacaccaaac accccacatg tgggcccgtt ccatccgtct tatcggccga 180 ttaagaaact atctacaaca gaagtttctc aatatcttgg tggatagcgg actccagatc 240 gatagtcttt ttgagggttg ttaccacagc gaagcgtacc gcttgctgtt ccagatcgaa 300 aaaacgaact ccacgcctag ctctctagcc tgtgcaagca ccgttttacc tgtcggtgaa 360 aacgaaactg aaggcacacc tgtcccgccg tgtatttaat gaaataataa aatggttctc 420 atgaataaga cggtcttagt ttcgtttttg aaaggacaag tatgagtgtc cccccacaca 480 tccccgcctt ggccgtggac tcgagcctga actttcgtgc ggacctgttt tctgacgaga 540 accgacactt tctagtcgat ttagtaaccc aaagctgcag cggctatgtg ggactgtgta 600 acgccggact tcccatggcc acctatgtac tggaaacgct aattgacttt caggttaaaa 660 ccacatacat gaaaattaag cccattgccg taaaagtgct aaagatctgt attctggcta 720 actacctaaa aaacagtaaa gaattatgga ttgatttgaa agctaaccta gacgagatta 780 attctggtgc aaataagcaa agactgtaca gaggctttta caaactatgt cgtgataaaa 890 actcgatgga cacttaccga aacgtcaccc agcagctaga cgccggagac gtgacaatgg 900 gcgtattcaa acaatccctg actcagatgc gcgagttaat ggaagtctcc gatctacacc 960 cctctgaaaa tctccaacca atgtacgaat ctctcactaa ctacaacctt ctctacattc 100 ccccaccctt tacagaccct agagccatcc aaatgtacag caaaaactta agcgatctta 1080 cgaaacgtgc taatagatct tttaatctac taactgaaac aaacaggtcc aaggaaccta 1140 accacgtagt taacgatgtg ctttttttac tatcggccag acacttacag ttccgacagc 1200 aactggaatt agaaatactg gcaaactgga tacttagtaa atgtaactac ctatgcgaag 1260 acctgtattt tgcctacaca caggtcccgg aatgtcggag tacgtttatt aattacgtta 1320 gcggtttaca agccatacgt aaagtaaaag agcccgtttt ccgtcccata ctccacaacc 1380 tgtgcaccct tctaagaaca ttccacgacg ccaacgttta catgtgccct caatatttac 1440 acacggccat ctttttgttg atgcaaagaa tatccaaggt cgcagaaggt gactcgtcag 1500 attcggaccc tgaaaatcaa gaagccacac aaaatagaga cactctcttg agacgctttc 1560 acgaagggga acatatcgac ctagaagccg atcctactac cgccccttca cagaactttt 1620 atttcgcaaa gaacccttac ggtaacggag atttgttttg cctcccggag aaacctagcc 1680 agtttcttag acgcaaagtg tggttaccca agagaacctt ctgtacatgt cattcaaaat 1740 ggaaaacgga acctttgaca aagacgcctt tagcattcca cgtctgtata gcttagttat 1800 ggaaggcgct tccagacaag cctccacaac ggccaagcaa ttctcgcaag ccttagaaaa 1860 agcgccgttg ggacatgcag aaccccgccc cacagatcac agcgacctat tcgccgacgt 1920 ggagatcagg ccacaacaag actcttccga atccacttcg tctgcgccct ctacgtcatc 1980 cgccccttct gctcatcctt caccgaggcg acagagacta gaatcagtac ctcgtcaaag 2040 acgctacctc agcctgcaac aattctcacc ctactccttg gcccgtcaca accgtcgccg 2100 aaggagacgc catcctcccc ctcccccgag aggcccagcc cacacctctc gtcaaggacc 2160 agatgtttcc tcgccatcta cttctggcga ggaccccaga gacagtctag cggacgattt 2220 tcaaagccgg ttgtgaggga ggatgggact ttcagagttt atgaaataaa tgctttttat 2280 tttgtaacat cgtgtatgtt ttttttaata acgcattaac atttacacaa cagatgaagt 2340 aaactttatt tcagtacaaa atgcatgcat tcacacataa gaaacccgac tgcggttacc 2900 gcgctgagaa ccgcggccgg cgcggaacag ccggagacgc cggtttgcca cgcagcgttc 2460 acacacactg tcatcaaaga ggtagcctcg aaccgtctcc tcgcgatcgg aatcgtcatc 2520 ctcagcggtt ccgacaaagg acatttcaaa agctctcatg tcggcaatgc caccgagaag 2580 cttgcacctc acttcctccg catcataggg caacgattgc aagatcagcg aatcggagag 2640 ggcttccagt tcctggggcc acagtctgcc actggcagga ctgtctagca tgacgctggt 2700 aacgcaaaat tgcaggtggg ccttaatact agcatgaatt cgttccacca cttcggccgt 2760 ggtctttggt gcttgttctg attcatcatc gtcatcattg aacatgttca taggatccac 2820 gggttcccta ccgtgcagac aatatggaat tttttccagt ctgacggtgg ccgcacgttt 2880 acgatcgtac cgatggtttt gatgaccttt ctgccccatg acacatgtaa acatactaaa 2940 ggtatcggcc agacggtaaa tgccattaat agacgggtcg aagccgtaga tcacgccaaa 3000 cttgtctgcc aacacgtaga gtctcaccaa aaattctcct gattctaaga tgcagccaag 3060 cgccccgagc aactgattca tgcataccaa acggggaaca catcgtacca ttatttcaaa 3120 acttttgaag gcttcaggtc gcatgacgct gaaacaggtc tcctggaact tgataatatt 3180 gctatcactg ctccaaaggg caaaatgggt gtctatctgc tcaccggcag ggtcattgat 3240 tttataaatg gtatgattat ttttgttcag tattccactc aactgatctt cctcccagtc 3300 aaatttcaac aactgtttga taatctcatt atcataggta attaatggac actgataggc 3360 ctcttccttc tgaagatatt cgcaacgacg cagtccaagt ttcataaagg ccttcatatc 3420 gggtgccaag cagtagacac atttttccat ctcctcgtag caatacacgg caccgctgcg 3980 accgatcatc ataatgattt ggtaagaacc aagtttttta agttccacaa ctccaaaggg 3540 ttccatggct tcctcgcagc acacgtacct tcctaaagaa aaaacagcaa caaagtcatc 3600 tatttatcat tataactccc cctccccctt tcctacccaa ctaaattgga aagttacata 3660 ccttgaaggc acacatcgta atacttggga ctaaaatgac ccaatagagt acgaggacga 370 agctggatca tagcattttc aggccaagca acgtgcaatc tggtcccaga ttctttgtcc 3790 aaaaagtcaa acaaactggc aggagttgca gcatgcaaag caatgcagcc gtaagccatc 3840 aaagtatccc gaaggtcatc catgccgctc accaagcgat aactcatgtg ctgagttgag 3900 gtaggtgctt gacgagctgt gctcaagctc actgaagtgt gaccaagcca cgctgcatgc 3960 tatttataca tagccctgag ggctcagtcg cgaagattcg ttgattcatt gatgtaggaa 4020 aattgagatt taatggacgc acgtatctct tgccgcttca tgcacatctc gtggatatcg 4080 ttctgcatgt gttttcggct ccgttgcaca agtccgccga aaagaccgag cagcataaca 4140 gcggccaaga cgacggcgct caagctgaat ataccccaag cacaccaaga aagtcgagga 4200 gaagtattgg catatgtcca catctgagtc acttgagtcc acgtaggcca ttccagtatt 4260 ccatacgtga tattgtctgt tatgttttca tgagtcactt ttactggcga tcttgtgaat 4320 tttttcagac gattaagcaa tcgcaaacac acgtcactca aaaaaaagcg atccgtgtcc 4380 gcgtgaattg ttaaccaatt gaagatactg gcagccaacg cttcggaaac attaccgttg 9440 aactcggtaa tgttttcgcg tctccacgca agtgccgaat tccgtcgatc gcggcttgtc 9500 acactcaaca catttcgtcc ccacgcttcg ctctccaaca caatttcacc ctgagtttcg 4560 ttgtgattgg aagcattccg actacattgc agactgccca taaacggcgt gactcttgac 9620 agattgctta acacgtatag gcggtgcata actcgcccat tcagatagta ctgcagaccc 4680 acacgtaaaa ccatgttatg ccaggcccga gtagacctac gaaacgtcat attgagtttc 4740 agcttagttg tggctaaata acaggggcct tcatagatac ttgttccgtt gtaagtgcag 4800 ttcagcatgc acgacgctgt gctgctcatg ttgccgcggt actgacagtt gagaacccat 4860 ccgtcaaccg tcagacagag cagcggcatg cagatgcaga cctaaacatc caataaacag 9920 aacactgagt tatccataaa cattcaggtt cacacatctc cactcacact ccaaactgta 4980 aacccattac ctgacacagg cggtaggcgc tcatcacccc caagaagatg agacacacaa 5040 ctgcgtggtt atacaacaaa gccgtttatt acaaaagcac actagtgatt gacagaaggc 5100 gtgtctacag tgacaccaag caatgcgggt tgcacaattc agcaaaaaaa aaatctacag 5160 agatgccgcg ccttccatag ttaaatcgat aatcgtatcg ctgtcgctat cggaatcagg 5220 ctggactccg agcttcttag ggtggggggt agggagcgaa cactgtcgtg tcagtgcttt 5280 cttctccggt cttccttcag tttccggatt gggagtgggg gcgacgggaa taacgttggc 5340 caacaggcta tcgcgatcca caaagggtac cggaattttt ccgtcgcgaa cgcgtctctc 5400 cgcgtctagt agagctcyc* ywvtsrrnrm amhadatara grahntrwhn martndatns 5460 tathccdcgt msnwrmansy mbarahddcc whnmartnwh nmartnhhhc ccwhnmartn 5520 nrmawhnmar tnmcrstwrd hhdhccdccc ttdgdandaa daa*artntr yctabwrddc 5580 mntsmmaryn rmatndcmnt smmarynrma tncmbmcrst wrddcmntms wrddcwrddc 5690 ~yt 5643 <210> 40 <211> 2657 <212> DNA
<213> Stealth virus <400> 40 gbbbbwrbbc cgagctcgac cgggacggcg cgctccacga ggtgcccgcg ggcatgacgg 60 acccggcccg ctgagcgccg gtccggggcg ccccgctcga cgggccgccc cggaccccgg 120 acgatggagc cgggaccacc ggccgggagg gggacccgtg ggctggtaca ccgagcacgt 180 cgtcggcacg grccgcgccc cggcgctgtt cgcgctcgtc gggttcgtcg tgacgttcgt 290 cgtcgtgcgg tcgatcacgc gccgcatccg cgcccgcacc gaggccgccg cagcgacgac 300 cacgggggcg cccgggcacg agcccccgga cgacggtcgg ccgccgtcgg ggcggtccct 360 cctcgggaac gtgtcgatcg ggggcgtcca cgtgcaccac caggtgtggg gcatcctgct 420 cgtgctgctg accggcatgc tcgagttccg ctactccccc gggcacccgt ggtcggaggt 980 gctcgcgctg ctgttcggcg cgggcgccgc gctcgcgctc gacgagttcg cgctgtggct 590 ctacgtcgac gacgtctact ggtccgagga gggtcggcgc tcgatcgacg cgatcctcgt 60.7 cggcggggcg ctcgrcgggg cgctgctcct gtccgcgtca ccgatc,ggcg tgacctcgga 6Eu cggcacctcc ggcggctggc tcgcctacac cgtgacggtc gtcgtgcacc tcgcgctcgc 720 gttcgtgtgc gtcctcaagg gcaagctcgc gacgggcctg gtcggcgtgg tggtcccggt 780 cgtcgcgctc gtgggcgcgg tgcggctcgc gaagccgtcg tcgttctggg cccgacgccg 890 gtacgggcgc cggccgcacc ggctcgcccg cgcgcaggag cgcttcgggg cgcgctaccg 900 ggcgcgcagg gagcgcgtac ggaacctcgt cggcggccgg gccgacgacg acccgccgtc 960 ggcataggcc agggccgtca ggtcaggtcg ggcgcggccc gcacgacggc ggccatcgcg 1020 gcggtcgccg cggcgtcggc gtcggcgtac cgccagcccg ggctcacgac ccgcgcgtgg 1080 tcgttgaggg cggcgagcac gtccagcacc gcggtgccca gggcccgcgc gtgcggcgtg 1140 aggccgccgc ggatcttcag ctgaccgagc acgatcgcga tctgcgcgcg ggcctcggcc 1200 gcgagcgccg cctcgtcgac gtcgccgcga ccgagccggt ccaccgcgcc ctgccgaccg 1260 gccgcccaga cgtcctcggg gacgccgagg tcccacgcgg cgaggaggcc gtcgacgaag 1320 gcgggcagcg cgtcgtcgcg cccgtccgcg gcgtaccact cctcgaggtc gcgcagcgcg 1380 tcgtgcccgg agtcgttgcc gaacggcgcg aagtcctcgc cctcgtcgta gaacggctcc 1440 ggcgcgaggg acacgaaggc ggggtggctc gtcgcgggcg acagaccctg gtcggggtcg 1500 tcgaggaaca gcgtcatggg ggcgacccta gaccggcgcg gggcgcgccg tcgcgcgcgc 1560 ccgtcgtcgg ggctgccgtg cggaccgacg gtcccgcgcc gcgggaatcc ctcgatgcgc 1620 aggccgcgca cgtgccaggg tgggcgcatg accgacgcca ccgacgcacg ccccgacgcc 1680 ctggagcggg tcgcgtggcc cgtgcggacc gctcgcctga cgctgcgccg cgcccggccg 1740 gacgacgcgg acgcgctgtt cgcctaccgc agcctgcccg aggtggaccg gtggctcacg 1800 cagcggttca ccgcggtcga ggagtggcgc gagcaccacg tcgagccggg gcggctcgcg 1860 acgacgctcg tcgtggagca cgagggcgcc gtggtcgggg acctctacct cgcggtgcgc 1920 gacggctggg cgcagcgcga cgtcgtcgac cgtccgcacg acgacgaggc cgagatcggc 1980 tgggtgctcg acccggcgca ccaggggcag ggctacgcga cggaagccgt gcgggcgctc 2040 ctgcgggtgt gcttcgagga cctggggctg cggcgcgtcg tggcgaacgc gttcctcgcg 2100 aacgagccgt cgtggcggct catggagcgc gtggggatgc ggcgcgaggg cgtgggggtg 2160 cgcgactccc tgcaccggga cctgggctgg gtcgacggcg tcgtgtacgc gctgctggcc 2220 gacgaggcgc gagcgggcgc ttgaccctga cgcgacgtca gggcgcaggc tgcccgcatg 2280 accgacacgt tccccgcctt cgacctctcc cccgtccccg ccccggggcc cgacgccgtc 2340 gccccggagc cgttccgcgg catctacggc atgccgcagc tcgtgaccgt cccgacggac 2900 gacctcgcgg cgtccgtcga gctcbycbbn rmamhadata ragrahntbb bbdwhnmart 2460 ndatnstath ccdcaaaabg tmsnwrmans ymbarahggc cwhnmartnw hnmartnhhh 2520 cccwhnmart nnrmawhnma rtnmcrstwr dhhdhccdcc cttdgdanda adaa~rtntr 2580 ytabwrddcm ntsmmarynr matndcmnts mmarynrmat ncmbangbrm crstwrddcm 2640 ntmswrddcw rddcmnt 2657 <210> 91 <211> 2969 <212> DNA
<213> Stealth virus <900> 91 gbbwrbbccg agctcgaaga gatcgtcagc aacgtcacgc gcgaactgca aaaatacggt 60 gcgcggccac tcggcatcgt ctaccgcgac aatgaaccct attcggaacc ttgttcgttc 120 ttcaacacac tgctcacctg cggcatttcc cgcgacatgc gcctgccgcg catgggcatt 180 cgtagctata tcgggacgtc gcgtctgcat ttttccaagc ggaccatgca ggcgcagggc 240 ccgaccgaga tcgaaaaccg cttcggcgcg atgctgtcga tcaaggaata tccgcctttc 300 tccggcccag ggatgctcga cgggctcctg caaatgaacc acgaattcat ctgcacccag 360 tccttcaccc ttgccgacaa accgatcgcc caggagcgca tctcccggct acagcgccag 420 atccacgcgt cggatgaatc tggcagcacg gtcgagactg acatcgattt cgcgctgaac 480 agtctgctca accaggaggc cgtcttcggc tatcatcatt tcagcctgct ttgcctcgcg 540 cgcgatctag ctggtctcga caaggcagtc gcggaactcg gctcctgcct cacagacatg 600 aacatcaact ggctgcgcga agacctcaac atggaggcct ctttctgggc gcagctgcca 660 ggcaaccatg cctacatcgc ccgctcctgt atgctatcca gcgcgaactt ctccggcttc 720 tcgtcacttc acaatttcgc aacaggaatg gccacgggta atcattgggg cttgccgatc 780 tccatcctcg agacgacgtc gcagacgccc tactggttta atttccacca gcgcgatatc 840 gggcacttcc tggtgactgg ccccaccggg tctggcaaga ccgttgcgat gacattcctg 900 cttgcgcagg cattccgcat ttcgccggaa ccgcgggccg tcttcttcga caaggaccgc 960 ggcgccgaaa tcttcatccg tgccgtcgga ggcgcctacg aggtgctcca gccgggtgtc 1020 gaaaccggct ttaacccact gcaactcgaa aacaacgcaa ccaaccgcga gttcctgcat 1080 cgtctcctca aagctatgct cgctccggcg gatggcggcg gtttctccca agaggaggaa 1190 gacactctag agcgtgcaat cggccgcatc tgccaggagc cgaccgaaca acgcacattg 1200 gccaatctgt ctggtctcct catgggcagg gcacgatccg acgccaacga tctccaagcg 1260 cgtctgcgcc cctggtttga aggtgagaag gcctggctct tcgacgcgcc gcaggatgtc 1320 ttgtccttct ccggtcgacg gattttcggt ttcgacatga cgcacatcct cgataatcac 1380 gaagtacgca cgcccgcgct gatgtatctc tatcatcggc tggacgaatt gctcaccggc 1940 gaaccggtcc tcatcttcat ggatgaaggc tggaagcttc tgcaggaccc ggtcttttcc 1500 aactatatcg tcgacaagat gaagacgatc cgcaagctca acgggatcgt cggttttggc 1560 acccagtcag cggccgacat cgcacgcgca ccgcaatcgc acacattgat cgagcagtcc 1620 gcaaccaatc tgcattttcc caatccacgt gcggacgagg aaagctacat ccggcgcttc 1680 ggccttacgg ccaaagaata cgccttcatt cgcaataccc cacccgagcg gcgaaccttt 1740 ctgatcaagc atggcaacga ctcagtcatt gccaggctcg atctctcgtc gatgccggac 1800 cttgtacgcg tgatgtccgg ccgcaaggag acgatcgagc aatgtgcgac gctgcgtgcg 1860 cagcttggcg acgatccggc taactggttg cctgtgttct gtggctggga gaatgcggca 1920 tgatcaggcg tcttccccta ctccttttcg cgttcgcggc accgcccgcg cttgccgaca 1980 tcccgaccat cgacagcacg gtgstcsatg agcacsacga tcgygaccgg aaaaccaccg 2040 agataggtaa ggtcgwcaag gagcgstacg tcagcaatca garcgttacc tgcgssatgt 2100 atcgccccgg acgaaaarac gatccggtcg gtgccgcgaa cgccaatccc gcggttgccg 2100 gcctcgyccg ccggatcgcg ssccaggagg ggatcgacga aaatcagttc ctggcgctgg 220 tctatcagga gagtcgcttc aacccgtgcg ccaaatcgtc ggcgggagcg atcggccttg 2280 cgcagctgat gcccggcacg gctggtgacc tgggcgtcga tccctacaac atcgaacaga 2340 accttcgcgg cggcgcacgc tattacaagc agcagctgcg ccgctacaat ggcaatgtct 2400 cactggcgct cgcggcctac aatgccggtc atggcaacgt ccagaaatat ggcggtatcc 2460 cgccattcaa ggagacgcag ggctatgtcg ccagcataac gcaaaagtgg cttccggcct 2520 ttggcggatc cga~caagtcc ggcataccac tcaactatgg cggcggagga gcgtacgaaa 2580 gcgcgcgaac cagcacaatg aacgcgatgg ggctgacggc tgcgatcggg gaggggtccg 2640 gcgacgtcat gtcctggctc atgcaactcg gtggtctggg gtccggcacg atccaggaca 2700 gctgggacca caattccggt gcgcgcaatg ccaacctcga gctcycnrma mhadatarag 2760 rahntwhnma rtndatnsta thccdcssgt msnwrmansy mbarahmmbc cwhnmartnw 280 hnmartnhhh -cccwhnmart nnrmawhnma rtnmcrstwr dvvbdhccdc ccttdgdand 2880 aadaa*rtnt ryttabhwrd dcmntsmmar ynrmatndnb wdcmntsmma rynrmatncm 29x0 bmcrstwrdd cmntmswrdd cwrddcmnt 2969 <210> 42 <211> 6984 <212> DNA
<213> Stealth virus WO 99/34019 PCT/US98/2??44 <400> 42 ggbbvgvvvv gvbcgaattc catccaggct tttgcttaca gcctggactt ccagactcag 60 ctgcaaaaga ttcgcgacct caaggcacgc tttgccgatc tgattaagca gcagcatctc 120 aacgcgtctg aagaagtacc cttacccatg ccccacctac caggaaacac ggtcatcgcc 180 tccccgctgt cgtttgccaa gggcctggcc gccctagaga aatatgtttt gggcggctac 290 cagtggttaa ccgaatgtat caaccgtyaa cctctagtgt gtcaacgcat agacgacatt 300 cccggccgtt ttgccgtcaa ccgatattga ccgcaagaga gtcgccctag atcgcctcaa 360 gcggctgagt tttagtacaa agaacgaaat gtgttacgaa gttgtcgacg tattcggcct 920 tcaccaactc atgtccaaaa atggcgttcc catacacttt gtactgagct acggaaacgt 480 gtttttcaag tacatggcac tacatcacga tgataagcaa ttggcaaaaa aatttgccca 590 agttaaaaat ttggtgactg gcagatacaa agtggtaacg gtcaatgtcg ccgtagccca 600 gaccttgaaa accttctggt cccagatatc ccaatacgac ctcaaacccc tactctcagg 660 tcaaacactc ataggtttag gagaaactaa cagtctagta aacctaaaaa attttcattt 720 atattgtcgt atcagcctgg aacttgcagt tggatgtgct tcaggaacat cgaggtccgg 780 tcatccgcat gcccatcgat gatttatgta tcgccatcac cacgttttat cccgaataca 840 tctatggcat cgtgaaacac cccattcaaa ataccctatc ttcgctcgtg cgtgttctca 900 aaaaagacat cgttcaggaa gccatcaata acgtgactca gatgccaccc gtctatagcg 960 ccgatgagat caagggattc tgcatcaatc ccaaaatatg gtcatcggtc aatctgagtc 1020 gtgtgatgtg ggaccagaac ctcgtacgcc agatgtgcga cgtcggtccc cgcaagaacg 1080 gggctcagaa actgtggcag tacgccgtgg cgattatggt ctttccacag gatctactcc 1140 agtgcctgtg gctggagctg aggcccaagt tcgccgaaga gtttgcaacg ctcttcgact 1200 tcttccaggc cctttttgta cttttcaccc atcaatatga catcaccagg gagtcgaaca 1260 tgaacaccca cctagccacg ggagaagcca tcgttcagac cgtcggcatt cgacgcaaag 1320 accacaccga caagagtcta ttggacgttt ttattgaaac cgacaccgcc atagattacg 1380 tgttgggatc ctgggttttc ggcatccctg tgtgttgtgc catctatgtg tcagagatct 1940 tgaacggcag ccggctactg ctggctcgcc acattgagta taccgtgcgc gacgcagatt 1500 tcatgcacgt tcagagggcc aaagatctta acctcaacta tgtaatcaca caaacgtgga 1560 cgaacacccc gctagagcaa tgttggtttc aagcgcagat tcaacgcatt aaagaccacc 1620 tcagaactcc cctagaactc gattttattc cattagtcat ttacaacgct cacgacaaaa 1680 caatacactc cgtcatacgc cccccaacaa ccgccgaacg agatgtgtct cgcattgtgg 1740 tagaaaaccc cttccctacc ctgcccctaa tcgacgtccc ggagtctgat ctcgtga.tat 1800 tcgaccgagt tcctatcaac accgactttc tccgagaaga tcccccgccg tgtaccgtca 1860 gcgaggtcgc gccagtggca gcggcgtcag caaaggtggc aaagcccgcc aaagccagtt 1920 caacggctcc taaaaaagtc caggttgtaa aaacccctca ggtggatcga gtgcaggcag 1980 aaggttcgtc ggtggacgtt ccggaattat ccgatgatga ggaagattac gaaatcttaa 2040 cagaggacga atcgtacgag cttatagaac tgtcctcgga ggaagaacaa caatcactgc 2100 cttccgtgcg cacgttcgtc gagcctgtgt tccgccagca acctgtgcag actatcgttc 2160 gtagagaaga tgttattacc gtctccccta ccgccgccag ctccagtttc ccaaatcccc 2220 caatgaccac tctaactcaa aatgttgtaa acgccattca aatcctacga tccgtgcgcg 2280 tagatctt~a atcgatggct aaatcggtta acgaaaccat taaccgtctg cgcttcctct 2390 atctactgta gcgaggagac gcccgctagc gacgggttct ggctaccgcc aacatgcgca 2900 gtaagtccag cttaaaggca aacttgtctg taaagaagct ggacatccgg acgtacttgg 2960 acaacatggt gccggtcacg gggtgttcca tggactcctg gggcagatcc aatacattca 2520 cacacacgtg gcgccgcttc tcctcatcct tcttaacgtt ggtacccgtg ttgctcgagc 2580 tagacgacat gactgctgcc gtgacacacc gtctgcttca ccaaggcgca gccccgacac 2690 agcgagccgc agtcctcgag ctcgagacag ctgtcgcgat attccccggc ctggcaccgc 27~)0 gaacacagcg gcccctggcc gtgacacata agcttcagca gtcgcgggat agtgacggag 700 cgcaccacca cggtggaatc gcacgtccgc gcagagcacg gtagaatgat gtcaaacgtg 2820 acgaggtggt catagaccgc acacgcggcg ttcaacccca agactgcctt ccaaccaaac 2880 cgcaaacaac gttgcccaca aatcgtctca gagacaactt cgtaaacacg ttctttaatg 2940 acacgctgac ttccacaaag agaacagtgc accagttcgg cgttagtatt gaaaatgaca 3000 ctcttttctt ggcggtctct ataatagaac atagagttaa gggggaaatt ctgctcgcag 3060 tgcagcttct ccttgcccaa gttcaggcag tggccgcact gtcggcacac cacggcgatc 3120 agcgatctgg cgtctaggtg gcgctcgcac ttcaggcgac acagacacca gagcggaata 3180 tcaataacgc tgcctataag tcctccgcgc agcgccaccg ccagtccgta catcacgatt 3240 ttggtaggtt ccagcggccg cggttgttta tgggcgcgga cctcgtcatt aagtcctagg 3300 gcgcgcagcg gtaccagata cctcgggcag gtgttacaaa acgactgcat ggcttggcga 3360 gccatcacgt ataggggatt cccgcagggc acgggcccgg catggcgacg cagcgccgcc 3920 accagagagc ccagctgaac cgaactcggc ttccgacgtc gcgtccactc gttccgatga 3480 tagacagcca ggtcggcccg tccgtcatat ctcttggcgc gcaggaggga gaggcaagga 3540 gaactggtct gattcagcac gggaagtcgc aggtccactc caaacagaaa gcgatgcagg 3600 tcacccaaag cagaggaggt catgctatcc agcaacgcgc tgagcttttc ggcgggatat 3660 tgctgtagcc tgaggtagac atagtccgca tcgtagcgct caaagcgcaa aaaggccaca 370 gttcgcgaga ctccgtgaaa gcagctcatg ctgtacacgt aggccaggaa cataaagtaa 3780 ggctttgtca tgaccagacg ctgaaacagc gtggtaaccg cctctcgttc cacaggtccg 3840 caggccagcc attcgtgcag aaagcgctgg tacaggcgat ctccgagttc gcggttgaga 3900 aaccgtttgt cggtgacgaa gagttgcaga gcacaagccc gctcctcggt gtaagacgcg 3960 ccacgcccaa tcaccatctg cacgtggaag tgatcatcgt gcacgcagag aggagtgaag 4020 agccgccaga gcgcgctctg gaagtcacga gacatagcga tacagaagga agagtaagat 9080 tcccatcacc gcgccgatca gaagaaagcg caggtcgagg cggaacgagc ccagacgcac 4140 ctgcgtcagc gagcgactcc ctctgctgcc cgtcatcgtt cctcggggct cctcctcctg 4200 gccaccgcag cagccagggg cggcagcccg gcaacgacac acgccataga agccacctgg 4260 cggaggtgga ggcggcgtga ccggtggaaa cggcggaggt gcgatcgtca tccgcggtga 4320 gtgcagccgc ttgcggctgt tactgctctg gtgtctcgag agacccaaac ggcttcgcag 4380 cacggggccg ctggacgcgg ccgccgcctt tttagcacag agttccttca gcaagttctc 4490 gtactcgacc tcgttctcgg gaccgaaggc aatgagttcg atattgaaga ccgagggcga 9500 gttagacttg cgcaccacac acttagtgag caccccgtag gccgagggct taatctcctc 9560 aatatcctta agagtgacaa tcagcgaatc gttgaccttg agcacgttga actcgccaac 9620 gtggcgacac gagacgagct tcaacggcgc tcggacaaaa cagcagagag aaacagcgca 9680 gccggtgttt ttaaagataa aacatggcac gtgatcggtg cgactttccc aatagctcaa 9740 caggtactcc acacaataca ccgtgtccgt ctttaacata gcgtcacata ccgagtaatt 4800 ggggttcttg caaatgagcc ccgcgtcagt aacgcgcaat tccgcgggtc ccagcttcaa 4850 aatgcgtcgt gtggccgaca ctaagtcgtg atgcaaccct ttactgattt ccatgacacg 9920 cgaccacgac cgcgcacgtt ttatttaccc gaagattcct cttttccctc caggatcccg 9980 ttaatgtcca tgagcttatt gacgatagcc gttaatagtt tcgtcttttc ctgcagaatc 5040 tgcgcgtgac tgcaagagga acactccccg tgtacatact tgagaaacgc cgcatacttc 5100 tgacccgcat taacgaaatt caatctcgcg tctagcgacg gcagtaacaa ttcgtaaact 5160 cgcggaagca tcggttcgaa gcgcacttcg aagtcgtcct ctggttcgaa cagtccctcg 520 tcataaggat catcctgatc cagtcgtgcc gaaggagccg ccatcgcacc acccgatacc 5280 agcccaattc ccgcacacac ttttagcccg acgccgccac caacatgaac caccacttat 5340 cctctcgcag ttatatctac accggctggg aggtagacct cacgccgccg ctgcacgaaa 5400 tcacaaatga actgctgtgg cacgcgcacc cccgtcaagt acccgagacc accgcccccg 5460 acacgtcgca atgcggctcg gccgcgggcg gcggcagcag cggcggggga ggaggagacc 5520 gcgcaaccca gagcttcctc tttagccagt cccaatccac cgaccagcta accgggcaag 5580 gcggcggcca gttctgcgac cttgacatgg aactagctaa ctttgagttc tcagatacag 5640 aacgactgaa aagactgtgc accccgctgg acatcgatac ccgatgcaac atctgcgcta 5700 tcatcagcat ctgcctgaag caagattcag atcaagcctg gctactcgac tacagtttgc 5760 tgtgctttaa atgtaattcg gcaccgcgca ccgccctcag tctgctagtc accatgtccg 5820 agttgactca tcttttgcgt cagcactttc cggacctgca cgtggaccag ctctttcggc 5880 aacatgtctt gacggtgttt gatttccatc tgcatttttt tattaatcgc tgcttcgaaa 5940 agcagttggg agatgcagtg gagaacgaaa acataaccct gagccatttg gcagtggtca 6000 aagccatggt gatgggtgac gagacggtac cgtacaccaa acaccggcga tttagccacc 6060 acaaacagaa aatcgttgtg aaaatcccag aggccccgaa gcaacttcta cagatgttta 6120 cagaacacag cactccgtcc cccgagcgct tcacgtactt gcttttttac atgtggtcgg 6180 gcacgggcgc gatggcgagt acaccgctgt cggaattggt gcagagtaaa caacacctgc 6240 tgaacagcgt ggcggacgcc gacgacccgg agattaacaa agaagtcggg cctgtctacc 6300 tctcccccgt acccgtgttc caagtaaaaa accaaaccag caccgtgtgt ttgctctgcg 6360 agctcatggc ctgctcgcac tacgacaacc tggtgctacg cgagttgtac cggcgaatta 6920 catcgtactg cgaaaacaac gtgaaaatgg tggatcgcat ccagctggca ctagcagaca 6480 tgttacggga atgcgcgatg ccactgagcc cccagtacga ggacatgtcc cggtacgcgc 6540 gcctcccgcc cccggccgac tatctctcca gtccgaccat acgccccgac cccgtgttct 6600 gcctcgtgtt gcggcaagcc ggcgtgaccg gcatctacaa gcattttttt tgcgatccgc 6660 agtgcgcggg caacattcgc atcactcgcg aggaggttct cttcggaaga attcb~ywvt 670 srnmknrmam hadataragr ahntYwhnma rtndatnsta thbcdcgtms nwrmansymb 6780 arahrwbcwh nmartnwhnm artnhddtbc bwhnmartnn rmawhnmart nmcrstwrdn 6840 wdhccdbctt dgdandaada atabcdhrtn tryhtabwrd dcmntvhhsm marynrmatn 6900 mdddcmntsm marynrmatn rcmbatnatn stathwtdcd bcdcatndat nstathmcrs 6960 twrddcmntm swrddcwrdd cmnt 6984 <210> 93 <211> 8579 <212> DNA
<213> Stealth virus <900> 43 gbbccdbass chcksmgagc tccgttttcc cagcgagtgc gccacatggt agcgattcaa 60 cgttcagatc tggatgaatt cacgtacccc tgtcaagctc ttaaaaggaa agggatcgct 120 gtacgtcacc aaccgtgact gatgcaccaa agctaccagg acgcgttccg taggtctttc 180 tcgcgtcgat gacttcgtcg ttacgaggca gtggagacga gggccagtgt cttcctgatg 240 gctcgctgcc tcgcgctccg ctgcctcgac accgacgatc tgagactcga ggacataggt 300 ctgttgcacc gtatcgtaac ggtgcagcac cagcgtattg ggatctagct tctcccaggc 360 tccctgatac gggtcgaagc gctctgttaa acagagccag tcgtagtgtt tctttaaaaa 420 gtgctggcgg cgctcttccc ggtcgtaggg agccagaagt tcgtggcggc gatccatatc 480 gcgatcgtcc gcgtgcgggc atatgcactg atgttccatt cgaatttttt tctgacgctc 590 gggctcgaag cgtcggtacc cgaacactag tttcagaagc cccatccgaa aaaactctgt 600 gatgctgttg gccacgcgcc gaatgtggtg actaggttcg tctagctgga tggcgtacac 660 cgccccaaac caatccagca cgatcaccac ctcggccaca aaactgcgtc cggggcgcgg 727 tcgcccagtg gcccctagca gataccaggg cgtagccagg ttagccctga tgccccacca 780 ccagcgtttt gcttcgtttt ccgtgaggct gctgaaaggc cacacggccc gcagttctgt 840 cacggttttc atgaggcgca agatgacggc cccgtaaccc ggggtgtaca gcttcacatc 900 gtgctccatg atgcgatctg ccgtgacata aaagctgtcc ggggtggttt cgttgagaaa 960 caagatgtgc atagtgcgcg ggggacgcgg accgaatcgc atgaggctcg gcgacatgcg 100 ccggagctgg ttgtgtatgg cgtcgcgata gatgaactcc gaacgcatga ccccgtattt 1080 cgccaggtcc tctagcccgt gcgccacgat caccatgtag ttttcgcggg gttcaaaggc :1-10 gtagatgcga cagaaacgac ccaggcagat cacataatcc gtccgtaggt gatcgtgatt 1200 gtgatcgcga tgaggctcgg gtatcataac aacagcatag cccagggcac acagcggctc 1260 gttacagcag atcagtttcc tagccgcctg ctgcgcctgg agcagctgct ggtcgcgttg 1320 cagttgcacg taccagccct gcggaggccc caggcatagc cggcgcccct ggtaatggtg 1380 cacgtactgt tcgatctgcg aagtttgcgt gaaaaagaac agttcccgaa agtcggtcag 1440 cacctgtctg tagaattcca aaccctgcgc ctcgcgctcg ccgtgctcgg ccgacatcat 1500 cgtgagggac gacgatagac gaaaactcac ctcggtctgt taaccgatct agcgttcgga 1560 ccgatgtatc gagatctcgg tccgagctgc tgagcggttc aaagaccagg tttggggtta 1620 tcggcgcctt cgccaagttc tggaccatca tcaggacatc gctacatacc gacgtggatt 1680 atgaacttgt cacgtcagaa ccaatcggac ccatggaagg tccccagggc atgaaataaa 1740 cagacatttg cgaaaacacg gtgcagtcat caaaccactc acatgattgt ttttattatc 1800 agacagttta cagccaaggg ggtaaatata agccgggacg aggcacatct gggcgaggaa 1860 atggacgtcc ttccaaaagg gccgctttgg cggctctctg aaccagcact tgggaatagt 1920 aatcgcaggt cacctctttt gcatcttctt cctcactgtt gctgtctatc tcttcggaaa 1980 cgctctccgt cttcttgctt aaagcggctt tgcccccgtc agtttctaac atatcatcgt 2040 cacagacttg tcttggtggt ttttggggtt tctgtgactt ctgaggtttt gcctgtccca 2100 cgtaaactac aggcacggag tcattatctc tggcagcagc ggccgcggca ccgccgcttt 2160 catccgacaa catcaatcta agcctcgcga tttctcgttc tagctgagga ttcatctgag 2220 tccagatcga gtaacaccgt gtaccctgtc tcacttcttt agaatgcaca tgatccgag.a 2230 gacgccgcca gaaactgtgc gcggcttcca cttcggtagc ttgagggaaa tcacaacgta 2340 ggtgaggctc ccaactggca tcggccgctc cggccacctc gtgatagcta ttgcgaccgt 2900 aacaactacc cgggtggagc gggcgaaaac gatctcgtcg cgtcaaccac ttaaaacgag 2960 tatcgtaact acgatgcgcc gctccccggt ctatgtacag atagcggtcc cagaactgat 2520 aggtgcggtg agggcagtgc gtggccacct ccagcctttc ggcgtcagat agcgcgcggc 2580 tgaaacgccg accggcctgg tagattttca gtaaccccat ggtcaaaaga gaatccagat 26-10 cattagccag tcgacacacc tcgcgacgat acacgtcaaa gtaaaagaat tcaccaaacg ~7~~0 catccatgag gaccacccat tcggcatggt aagatcccga agggagaact tctcccacca 27x0 cgccgaaaat taacacgtca cagcagagac ggtctttaaa gaattgcata agcttcgcga 2820 acatctgatc gtccatacag agaaagggcc aacatgattt caggtcgttc ggctctccgc 2880 agatcatcat cgggcgagtc atctctccgg gggttctgag cggcaggcat tgccagcgat 2940 accgcgccat gacacatttc agatgagaca cggagtgatc gtttagacgc aacatagaaa 3000 ccatgtcatc gggctgcgta gtcaatatgg gcatcctgaa cttgcctgtg tagatactct 3060 cgcagtgcat caaaccgtgt cgcgcgaaat catccaggct actagctagg tagtacagaa 3120 cgtcctcatc ccggtccaac aaccaaagac tctcgtagcg ccccatgagc acaacgcgct 3180 tgcttttaga tggcggtcgt aactcatcct atacagataa ctgtcatcgc actgctcgtc 3240 gccggaatcg tcttcgtccg aagagtcttc atcggattgc tggcgacagc tccaatactg 3300 cagatagccc attacctcca gcggctcttc gcaacagatg agcttgcccc aaggcgagtt 3300 cggaccgctg cacggtgtat tgtccccgaa aatgctcggg aaggtcgcaa acaccatccg 3420 ccagccaggg ggggccgaga taggcacact gatgcggcat tcggctttga ttgacaccag 3480 agtacgaagc gtgctctgtg aatcttgatg agtaaacacg tccttgaacg cataaagcat 35x0 ccgcctgatg gcgggccctg aggcgtaacg ataggactgg cgtagcatgt tggtgtgcca 3E00 ccgcacattg gaatgtcacg ggctttatgc cctctgtgaa atgacgtcgt agatgtgtgc 3Eo0 caggatcacg gcttattaat tgtggtgtgt atctt~cgaa agccgttcag tcggctgcgg ~.~0 gttgcccgac -ttcacgtcag raaaacccag agccgacatg aattccagct gccgtaacat ~ '-.0 aaccgcccta acccctttgg gcccggggcc catcattacg ggttacgcgt gcgtttttct 38-i0 gttcggggt,~_ -ttaggacatt tctatctagg tttcaaaaac agcagacgac aacgc:.aaoc =°~70 gaatacgttt agcgatattt tattcagaca tttaatgatt acagaagaag tcttcacc~~ ._.._ caccatcccg ctgtggactt accatctgat cagcaacggc gacctaccca gcccgtggtg 9020 tcggggttta accttcgttt tctatctcac ggcttttgcc cgcgcgtttt tctacctgct 4080 cctgtcctgg gaccgctaca acatcatcgt ctgtcgtcac ccgctacccg tgcacctgga 4140 ctacactcaa gtggtgggcc tagccgtctg gttagctgcc gcgctggcag cctcgccctt 4200 ctctattttc aacggcgacg tccagcaatg cctcggcaac atgggcaaag tgcccagcca 4260 atcctccgcg accctcaact tggaagtgca catgtgcact ttctggatac cgctcgtcgt 4320 gacggccaac tgttactatc aagccaaacg tcaggcggcg gccgatcaga agatcgaact 9380 tcaaaaatgc gccttactag taaccgtggt tatggtgttt accatcatct ggttcccttt 9440 ccacctggtg ttgcttatag atgcgctggc gagcctcagc cacgtggatc ccacgagcgc 4500 ctgccactgg gcacccatcg tagtcatgtg cgaatgtcta gcattcgcct acgtcggtgt 9560 tagcccgatg gtatacttct tcgcctgccc taccgtgcga cacgagtttt tggtgagcgt 4620 gcgccccttt ttcttaaggc tttcgggtaa gacatgggga ggctacgttc cggtcgacac 4680 acaggcaact gcgaacaaac cagatccaac gaccgaaaac gagtaccaaa ctatgcatta 9740 aataaaaagc cgtaatgtca atcactatgt tctgttttct ctacgttgtc gataacgcgc 9800 aagcctggga ataaacgcgt gctatatgat catacagcat tagtacgtta gtcaccaacg 4860 ctagaacaaa ccatggccaa cagctccgca aacgagtcgt gccaactcaa caacactctc 4920 caggcgttgg gaatacccaa ttctgtaccg atcagcatat acggtctttt tgtagttatc 4980 ggactgattg gaaactttat gttagttttc atattggttt acagacgcaa actcaggttc 5040 cccagcgaca tctactttct gaatgctgcc atagcagaca tattttgcgt ctgcatgtta 5100 cccgcctgga tacaatatgt agtagaatca gtgacgctca atcggttcgc atgcattact 5160 ttttcttttg ggttttacat ttctctgttt ctacaatcgt ggatgctcat ccttatcacc 5220 gctgagcgct attcatcttt agtttggatc gctccgaata aaaaaaccac cgcgattaaa 5280 agatgtgtat gggcctggtt catgtctata tttcttgcat ctccgtattc tatctttcgc 5340 aagtccgatg aagttgaaga atgtctcctg ggaaatttca cctggcacat cggggaactt 5400 taccacgccg ccctggatct gctaatcacc actttgactc tcatcatacc actcgctgtg 5460 ctgctgattt acagtttcag aatcagcaga tccttctggg gaaacagaaa actgaataac 5520 aaaaccagcc tgttcctcat gcaaatcttt gccgttgcgt tggggttctg gggccctttc 5580 catctatttg tgtttataga aaacgtaacg caccacttgt acggcataca acagatttgc 5690 agagtacgat atacgcgaca cctcgtcagt ctgctaacgg aatctctagt atttctacgc 5700 tcagttttta atcccgtcgt ttacctaatc atcagcgcca aatttcgtag acgcgtccaa 5760 catctatttc aacgcattcc atacaccaat ttggaaatgg aaaccgacaa ggtggctgaa 5820 acaatggaac tgaaagccag aggtatggat gtatctgacc ctacacccca cgactacgaa 5880 tgtttcctgt aaacccctac cttgaattaa cttatggtaa caaaacactc acaatcgaaa 5940 aacatgcgcg gcggaacccg gggagcaaat aaccaaccgc aacatgacta cagaaccctg 6000 ccacgtaaac gacactctga gcgcctatgg aataactccc agcatgatca tcagcttcta 6060 cggcttaact gggattattg gttttacggc aaacattgta ataatttatg taatgtgtgc 6120 taaccgcctt gagcggtctg cgcacgatat ttattttata tacatggtat gcacagacct 6180 gagtataatt attacaatac ccatatgggt ttattaccta acaaaccaag acaaaatata 6240 tggttgggaa tgcagtcttc tgtcattcac gttttatgtc cctcttttcc tttatccata 6300 ttttataatt gcaatagcca tcgaacacca tcgaactcta attctagaca agcccgttag 6360 cgttaaaact gcaaacataa gctttgtaat aatctttatt attgtaattt taatatcatt 6420 accctactgc atttttagac aaaccagcgg atttcactca tgtatttttg gcaacaacac 6480 gtggaatgta tctgctcccg ctcgcaccgt aatgggcatt acaattaacg ccttcacata 6540 tgcacttccg gcctcggtgg cgctatttta ttccatcaga atttattcaa cacgccgggg 6600 tagtaaaaag cgaaataaaa gagccagttt ttacatcgac gttatgactg ttaccatgtt 6660 atcttttaac _ggacttatca atctcaccat atttaaaaac atggttgttg gttactcgca 6720 aaacaattca gattgtgatt acattaaacg agaacacttt tttggcatga tgggtataac 6780 ccttgtgttt tttagagctg ctatcagtcc cattatctgt atgtacgtca accggaaaat 6840 gtttaaaaat ctctgcgatc tataatcatr caacaagatc tagacgcgtg tacgaaacat 6900 aggagggtca actcacaaac cgcaacatga gtaaccaaac ctgtaacata aacgacagtc 6960 tcattgccta cggactgact cccggcgtta ccatcggcgt ctactccctg gccggaatcg 7020 tgggtcttgc gggaaacctg ttgatactct gtgttatgta tcttgggcgt cctaaatggt 7080 tcgcgcacga tatttttttc atgaacatga tgttcacgga cctggctatg attctgacga 7140 tacccgcgtg ggtatactac ctaataaact actcacagct ggaacattgg gaatgtattg 7200 gcctgtcctt cgcgttctat gttcccctat tcgttcactc cgatctcata gtcgcgatag 7260 ctatagaacg ctatcagagc ttagttagaa acaagcctgt cagcgtcaga gccgccacag 7320 taagctgtgt gtttatctgg atcgtcgtca ttttggtttc atctccttat tacatgtttc 7380 gaggaaaaca cgaaaaccaa tcatgcattc ttggtaacta cacctggcat atacccggtc 7990 ctctccgtac cgtcatgaac gtcgcaatta acacatggac atttgtggtt ccggtcgccg 7500 cggcaatgtt cctgtctctc agaattcatt catcttcatg gggcagcaga aaaatgaaca 7560 tcaggaccag cttccacatt gacaccatgg ctgtcaccat gctctttttc aacgggctgt 7620 tcaaccttaa catctttcga gacgtagtgg ccgatgactc acaacaaaaa agttgtgatt 7680 atatgaaaca acaacacttt tttcgcacga tgggtatagc ctctgtgttt ctcagacccg 7740 tctttagtcc tatcatttac atatgtgtca gtcgtaaaat catacagggt atctgcaaat 7800 tgtttataaa agtaccaaac cataccataa gctcggaacg tgtaaagctt atgtctccaa 7860 atagaatgaa cgacgatgcc ccagagcttc cgcccaggga atatgaatcc gcgttctaaa 7920 ttattgcgcg ttgatagcgc aacgacacaa ccagccgata tatgtttgag accggtcaca 7980 aaccccgaca ttgcaaatcg acattgttcg atttgcgaac agacttttta caaacatgaa 8040 caactcctcc tgtaaccttc tgcaagtgtt taagatcgac gacgcatctc gcgatgtcag 8100 cgtcggtttc tatagcatcg ccatatgcgt cggactcata gcaaacatac tgatattact 8160 ggtcctaatc aaaaggcgaa aacttacctt tgccagcgac gtctactttc tgaatgctac 8220 cataggcgac atcgttacta ctgccacgct accgatatgg atgtattatg agctcywywv 8280 tsrnmkdvts rnmkkhgyhg ydwcvbatsr cdwcvbatsr nrmamhadat aragrahnta 8340 nttkwhnmar tndatnstat hcdcgtmsnw rmansymbar acrrnwhvvd ccdbasschc 8900 ksmwhnmart nwhnmartnh dtccdbassc hcksmccwhn martnnrmaw hnmartnmcr 8460 stwrdbddhc cddccdbass chcksmttdg dandaadaa" rtntryrtab wrddcmntsm 850 marynrmatn dcmntsmmar ynrmatncmb '"mcrstwrdd cmntmswrdd cwrddcmnt 8579 <210> 94 <211> 6675 <212> DNA
<213> Stealth virus <900> 44 gaattcgtca tcatgacgtt cggggtttga tgttgccatg ttgactgacc tgcaggttct 60 gccgactgag ttccgttctg tgagtgtgtt tatttacatt caacatagat ggcgctaaac 120 agacaaacac agacatcaga aaacgttttt attacgggag tgaagagaca cagtggttac 180 agaccatggc aaacgtgacc ggtttctgcg ctgcctgttc tgcctccgga tcgggacgtg 240 acaggcgtat ggggaccagg tcctgcaggg cgatagaggc cccgaggagg gagagttggt 300 gcggcacctg gtgcaccgcc gacttcacct gatgcgccaa ggcggtgagc cgcccgcgat 360 tcagactgtg tttagaggaa atgaagtaga gctgtcccag tacggtgttt :.ttggtatgt 920 acgcgttctc gctcactacg ttaatttcta accaagtcct gggtagccag atggtgaccg 98u gcatgttcag ttcttggcgg ttgtggggga taaagagtcc caggaagggt ccgtagaatc 540 ggcgatagat tcgaatgagg tgagacgttt tcagtgccaa gtcgtagggt aagcagacgt 600 cgaggccgcc . _ -gttgccgtcg tttcggggta aaaagtaagg gagcggcgtg tccgaaaaga 660 aaggacgcgc gacggtttgt cgccggaggc gcagtcgaaa cgacacgacg ggattggatg 7~~~

ggagttggtg ttgtgcgctg cggaaggtta cgttgaatcg taggatcccg tcctgataca 780 gaatcaagga tgatagcacc aaatccggag acccgtcgtc tacgtagagc tgcccgaaga 840 tggctggtcc catgttctcg atcgtacttt ctgagagttt cacggagatg cggctggcaa 900 ggccgcgcgg tcccgagatt ccgccctctg cggtgtgcca gcagagggcg gacttgaccg 960 ggatcatcag ctcgggcgtg ttgttgcttt cgtcggtcgt gaaagttagg tccggcatat 1020 gaagcgatac gcagtcgtgt agtgttgtgt ggtgagtgac ttttcgtcgc agaggtagct 1080 ggtgtctcag gggcggcata gttttgaggg cgaagatgtt tagcgacagt ctcacgatgg 1190 acatatgggt cagctgttcg tcaataacgg ctcgaagaat attgcaacta ccggcctgtg 1200 cggagaaaag ggcggcgatg ggtaaaatgt ccgagtcgcc attggctgcg gcgcacagga 1260 ggcctcgctc ttcggggtcg cggtgcgggg tgatcggctc gagctgcagc ggggtggaga 1320 gcaagatctg gaacggatgc tctaggtcgg tcggttgaaa gtctacgttc agctggatga 1380 gacgaaacgt gccctcgcgc gtcaggggtc gcttgacgtg gtgctggtcc gtcagggtta 1440 agatggtctc gtcagattgc aggagatttg aggcctttcg ggggcggcct cgaggcccat 1500 tccgcaaggt tttgtcggct cgcggcatgg tttgagactg atctccgcag cggggcggct 1560 cagcctttaa atatgcaggt cgcggatttg ttatcgggtg aaacgtcaca gaccgtaaac 1620 attacctgtt cgttgatgag atcatcgagc tgccttagca taacaaacaa agccgagagc 1690 cgagaaattt cttcgtccgg cgacacgtgg ttggggcgcc cgcggggccc atcggcgtgc 1740 tcgcggtcca gccgcatcaa gagttcctga cactttacca gtagcatgga gctgtcttcc 1800 agtgccaatt tacgcacgta gttcatcgtc aagtcggaag ccaggttggc taccatggac 1860 attgagaggc acgcggtttt catgtccagg aggaggtggt tttcgatcac gggatcggga 1920 atcgtgaagg tggcgtcgcg aaacgtaacg tgttgtagtt gattgacagc agctttaact 1980 tcttcgtaag agcggtcgag cgaatacaga gccattatga ggatcctctg gttgatctct 2040 acagccagtt gcgagggtaa cagccatggg aggacgagat tccattgtcc cactgaaact 2100 ggatattccc gcaccaccgg accctgaaag agcgggggta gtaagcataa accgtcgcct 2160 ttttcccaga gaacgggccc ggtgttgagg acggtgtaaa gctgtccgtg ggtgggaact 2220 tgcatagcga gttggttgcc ctcgattcgc cgcagaatcg tcggcgtcat gttgcgaagc 2280 agacttcgga gtcgaacata gccgcgcgtg ctgtcaatgt attggtgcaa acccaggtgg 2390 tggtgtttga tgaggtggtg tcggctgggg acggggatga tggctcccgt gagcttagcg 2900 agtttaccca cgtccgtgag gctgagtttt tgctcgaagg tgcagaaaat ggagaagtcc 2460 atggtgccac cggttcttcc agctctaact agcgtgctcc gtcaaatagt cagaggcaat 2520 ctttacgagt taaataacat gtgctgatgc aacgggatga tttcgcctat cacgtagttg 2580 ccgaagtgag tttccgacgt ggcgagcgat ccggacggat tcttgagctt gctttccata 2640 agagcctgcg tcgtggtgga aaggatgggc aaggcctctt gcagcatgcg acagggattc 2700 tcgattaact gttccgttcc ctcgacgcag atgtattggg tgtcggtttc cccgcgaata 2760 cagtctttgg ccctaaggag atactcgtcg atggttttaa acaacgtttt gttggagtta 280 ataatgtctt ccgtgttaaa aaactgtgca caaggactgt agaattgcga attgtatccc 2880 agacgttcgc ggtttcgaat gttgtacagc atgtcaccta gggaaccccg gttggaggcc 2940 caagggttgc gtgtggaggc gaacgtttgg gcgtcggcct cggtatgatc gtacagagtt 3000 ttcatggccg cgtccgtgtc gtatggatcg acgcccaaca tgcaggaggt gcggccgcgc 3060 gggttgttag ggattttgaa ataattaatg tctgtagtga cgggtgtaat gatgatttcg 3120 catatggctt tctgtccgtg caggtttgcc gcggagtttt tctctgacat gctaccgaaa 3180 gttaacatag agatagcctc ggtgtccaag agctgcggac ggtcgacgcc agcggcgtga 3240 cggacccacc gatcaacatc gtcgtgtcga tggacgtgca tggggaagac gcggaagaag 3300 ttctgcacgc gcacgcccac gtcgctgcgc gatcggttta ggtacgcgat gcaggtggtc 3300 gaggtgtaac ccagacccat gtccacgctg ttaatgttct gtgtcacgtg atacgtcgta 3420 ttgatgtccc gctcttcttt agtgacctga ggattattga tgataagtga cgcgcaggac 3930 ttgccgctgt acagcagcat gtcgacctcg aaagtgtcgg tccgtacggc tgtcagagcg 3540 aaaccggggt gaactccggc tttggccatt agtgcaatgg agacgggaga tattttgtac 3600 tcgcgcacga tatttttttc atgaacatga tgttcacgga cctggc WO 99/34019 PCT/US98/27?44 atcatacagg ctaaggttaa cacagattgt agggtgttgg gacatcccgc tgtgtagcgt 3660 gagaaggggg agcggagcca gttccagtat tcgtgtgcca gagcggtggc cagcgggaaa 3720 ccgccgtcgt ggcgatggta gtgaggaaag tcggtgatgt atcgcttgat gtcgtcgttg 3780 atggctgcgc agatggtggg atcggagtag aagcggtgga aggggatcac gaaacagtat 3840 tctgccatga ttttgggagg tgttacggcg cagcatccgt tgtacaggac gtgttgcagg 3900 gacgtaaaat ctggcgtacc gtggcgctgg gccgggtcca gctgtgcgcg cacttccaaa 3960 attttggcgt gttcgggcac gaactggagg acgaggaaga gttctcggca ggcctcgtac 4020 aggttaacgt cttcgctggt accaatgtct tctaccatct gcgtcagcat ctctccgata 4080 gcttcgggtt cgttgggcat ggtgaaagcg gggcggtaga acaggtccac caacagagtc 4140 ttcagattca gaccgatccc acaggcccgg ttgttcgtca tagctggcat aaggcacagg 9200 tagaaaatct tctgcagcgt ccactcgtcg tcggtagctc ggtggtcgtc gacgaacagg 9260 ggttcgtcgg cgtccatagc cgccatgcgc gggacgtccg acacgccatg atgtcgggac 4320 tcgatattgg cgttgttgag gggttggcgg tcggcgacga tatggacgcc ttcttggttc 9380 cggggtaagt gagttacgaa aggcggccac agacggtgat cgtggagcgc gttggcatag 4490 gcggctagag gttcgtctac caggtgcccg ttgttgagtc ctgggagcga agaaacgcgg 4500 gtgacgagtc gcaggagggc catgatggtg cgataatgcg cgtggatgtt ggcgggcagg 4560 aggccgtcgc caaggtgctc gacgatcata gcgatcatgc tgtagctgtg gctgaaagcc 9620 aaaagttggc gattctgaaa agcgttgacg atacatcggg cgataaacgc gcggatgacc 4680 aagaaggcgt cggaattgcc gtggaccagc aggtccacca ggtagaagac ttcggggtag 9790 ttgggacagg acagggtgct ttttaacaat tgcagggtgg cctcgtagtc cggaggtggt 9800 cggagtcgga ccatctcggc gatgtgtgat gtacgtagtt cctgaaagga gctgggggct 4860 agtgcgtcag gaatgttgcc aatcacaatg cgcggggtgc agagggtgga ggtctccccg 4920 ttctcttggt ggtgcgtgag gtcgaagaaa gggtggagtt cggtgtacag ggttaagttt 4980 cctatcttgt aaaaatcatt ggttgtgtag tcctgcttga tctcgttgac cgtgcgcgga 5040 acttctcggc gtacgcggta gaagtgggtg aggcgcctgg cgataccggc catctgttct 5100 tgttggaagc gacattcggt gagtcgggct acggccgggt cggtgggaac gcctctatcc 5160 gtaaagacct gtaggcacgg tgcggattcg tacatgaccg ggtggcacaa ggttgccaac 5220 gcatcaataa agtcgagtcg ctccagaccg cggtcgcggt tcaagaggta agcggaggtg 5280 gggagcgcgt tttctttggt ttcggccagt ttcaccttgt tctccactgt ggtgtaggct 5340 cgatcttccg ggagatagag acccactgga aagaaaaagg tgagatcgat gtttctttcc 5400 aaggggtctt tggtgtcggt gtttttgtac actcgccgct ggtgctctag ggccacggcg 5960 tgttcgccaa gttggataac gtccatggat agcgaggtga gactgttctg tccggctttt 5520 tccagagagg agccggtgag atcggggtta cccgaggtca ggtgagcggt ataagagtta 5580 aagtcggcca ggatagaatg gtgagcgatg gctgtgacgg cgttttcggg gctgagtaca 5640 aaattgccgt aggtggccgg ggcggagaca ttttgtttgc tgatactgct tttcaggagc 5700 gtcatgagag tttgaacgac ctgagcggtg ctgactatca cgccccggag ctgcttgccg 5760 gagcctgtca cgtacgtgct ggggttttct aggatactgt tggtggtggc ttccaccatt 5820 tttgtgagca gcttcgagat gtagtcgcga tccgacgtgc ggttaagcag aaacatggtg 5880 ctgagcattt ttgttttgaa actctgcagg atgttgcttc gttggatgcg gttcagggct 5940 tgacggcaca acgtggcgtt ttcgaccagc gtctgcacca cgaagtaagg cggggcttta 6000 cgcaacagta cctggagaaa gcagtggatt aagcctcgct ccatggcgtc ggcggtgttt 6060 ttcaacgcac gcagcacggt gtgcatggct tcgacattaa ggatcttgtc gaggatggtg 610 ttctcgaacg tttctcgcag gtgcgtgaga caggcggcgc tgagctcgaa ggggatggtg 6180 atggggcttt tttcactgta tttggtaacc atgatggtgg tctgtctcga ggtgggcatt 6240 ccggcgccgc tggctacacg cggcacctgg atgtgaaaca gcattttccc tgttgtcatc 6300 ttgttcaggt catcgaactt gatggcgtgc gcggccgatg ccagggccgt ctggaggaag 6300 taaacccatt cgagacgatt gcagaaggtg ccgaagatgg cttcgaagtg gatgttgtag 690 cgttccgggt catctccgta gtaaatgcgc agactgtcga acatttcttc cccggcgctg 6980 *rB

WO 99/34019 PCTlUS98/27744 gtttttacat gcgtgagaaa gtcggccggg atcccgactt tcgggagtaa ctcgactgcc 6540 gtccagtttt ccatgacggc gtgcggcgat ggcttcctcg ccaaccgtct ttcagtgtcg 6600 cgcgccccag gacgctctaa tagtggagtc ggcggcggaa ccccaggtcg tcaatgtccc 6660 cgtacacgtg aattc 6675 *rB

Claims (22)

WHAT IS CLAIMED:

1. A method of detecting and characterizing a stealth virus, comprising; i) the isolation of DNA or RNA from a sample suspected of containing a stealth virus, such as a culture of cells showing a viral cytopathic effect; ii) testing the reactivity of the isolated DNA or RNA with a molecular probe(s) that contain 18 or more contiguous nucleotides identical to the sequences previously identified in a stealth virus, and, optionally, iii) sequencing the isolated DNA or RNA molecules that react with the probe.

2. The method of claim 1 in which the sequence of the molecular probe corresponds to the sequence of a viral gene, including genes of cytomegaloviruses, and in particular those of African green monkey derived simian cytomegalovirus (SCMV).

3. The method of claim 1 in which the sequence of the molecular probe corresponds to the sequence of a cellular gene that might be expected to react with one or more cellular genes that have been incorporated into the genome of a stealth virus, and, as a result of this incorporation, is/are likely to show minor sequence variations when compared to the original cellular gene.

4. The method of claim 1 in which the sequence of the molecular probe corresponds to the sequences present in the stealth virus isolate that has been deposited with the ATCC, and assigned accession no. VR 2343.

5. The method of claim 1 in which the sequence of the molecular probe corresponds to the sequences present in the stealth virus isolated from patients in the Mohave Valley and deposited with the ATCC and assigned accession no. VR 2568.

6. The method of claim 1 in which the sequence of the molecular probe corresponds to the sequences present in the stealth viruses previously isolated from other patients or animals.

7. The method of claim 1 in which the sequence of the molecular probe corresponds to a sequence present in a stealth virus that is subsequently isolated and portions of its sequence determined using the methods described in this patent application

8. A kit containing a nucleic acid probe reactive with a viral gene that encodes a major antigen involved in eliciting an effective cellular immune response, such that the probe could be used to screen for stealth-adapted viruses in which this particular gene has been deleted

9. A kit containing a nucleic acid probe reactive with a stealth virus and capable of distinguishing a stealth virus infected cell from an uninfected cell.

10. The method of claim 1 in which the testing is for the purpose of diagnosing a stealth-virus associated disease.

11. The method of claim 1 in which the testing is for the purpose of detecting a stealth virus in biological products.

12. The method of claim 1 in which the testing is for the purpose of detecting a stealth virus in foods.

13. The method of claim 1 in which the testing is for the purpose of detecting a stealth virus in the environment.

14. The method of claim 1 in which the testing is for quantitating the levels of a stealth virus for the purpose of evaluating agents for their inhibitory effect on stealth virus replication.

15. The method of claim 1 in which the testing is for quantitating the levels of a stealth virus for the purpose of evaluating agents for their ability to enhance the replication of stealth viruses.

16. The methods of claim 1 in which the testing is for purposes of determining the capacity of stealth viruses to recombine with, and to potentially alter the nucleic acid sequences of another virus.

17. The methods of claim 1 in which the testing is for the purpose of determining the capacity of stealth viruses to recombine with, and to potentially alter the nucleic acid sequences of a cell.

18. The method of claim 1 in which the testing is for the purpose of determining the capacity of stealth viruses to recombine with, and to potentially alter the nucleic acid sequences of a bacteria.

19. Nucleic acid molecules that contain nucleotide sequences identical over a contiguous region of at least 30 nucleotides to the nucleotides present within any of the sequences identified as SEQ Number 1- , submitted together with this application.

20. Peptide and protein molecules that contain amino acid sequences identical over a contiguous region of at least 10 amino acids to the deduced amino acids coded by a stretch of nucleotide sequences present within any of the sequences identified as SEQ
Number 1-submitted together with this application.

21. The stealth virus isolate that has been deposited with the ATCC, and assigned accession no. VR 2343.

22. The stealth virus isolate that has been deposited with the ATCC, and assigned accession no. VR 2568.