CA2279625A1 - Sterilization of organs and prostheses with coupling agents - Google Patents
Sterilization of organs and prostheses with coupling agents Download PDFInfo
- Publication number
- CA2279625A1 CA2279625A1 CA002279625A CA2279625A CA2279625A1 CA 2279625 A1 CA2279625 A1 CA 2279625A1 CA 002279625 A CA002279625 A CA 002279625A CA 2279625 A CA2279625 A CA 2279625A CA 2279625 A1 CA2279625 A1 CA 2279625A1
- Authority
- CA
- Canada
- Prior art keywords
- treatment
- tissue
- sterilization
- resistance
- prostheses
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
- A61L2/0088—Liquid substances
Abstract
Heart valves or other components for replacement of heart or other bodily organs and tissue prostheses or synthetic prosthetic materials are effectively sterilized by treatment with a coupling agent known to create amide linkages between amines and carboxylic acids in the presence of a lower alkanol. Such treatment has been shown to be bactericidal when carried out at 40 °C for over 1 hour. The sterilization treatment preferably employs EDC as a water-soluble coupling agent, plus an optional coupling enhancer such as sulfo NHS or NHS, in the presence of isopropanol or an equivalent alkanol. Such sterilization treatment is preferably carried out at a temperature above ambient temperature in a buffered aqueous solution. The treatment leaves no residuals other than ones which are nontoxic and biocompatible, does not affect the resistance of the tissue to thermal denaturation and to digestion by proteolytic enzymes, and surprisingly also increases the resistance of fixed biological tissue to calcification.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3752897P | 1997-02-10 | 1997-02-10 | |
US60/037,528 | 1997-02-10 | ||
PCT/US1998/002395 WO1998034650A2 (en) | 1997-02-10 | 1998-02-09 | Sterilization of organs and prostheses with coupling agents |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2279625A1 true CA2279625A1 (en) | 1998-08-13 |
CA2279625C CA2279625C (en) | 2008-01-29 |
Family
ID=21894817
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002279625A Expired - Fee Related CA2279625C (en) | 1997-02-10 | 1998-02-09 | Sterilization of organs and prostheses with coupling agents |
Country Status (7)
Country | Link |
---|---|
US (1) | US5911951A (en) |
EP (1) | EP0986405B1 (en) |
JP (1) | JP4271262B2 (en) |
AU (1) | AU735988B2 (en) |
CA (1) | CA2279625C (en) |
DE (1) | DE69814070T2 (en) |
WO (1) | WO1998034650A2 (en) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040067157A1 (en) * | 1993-07-22 | 2004-04-08 | Clearant, Inc. | Methods for sterilizing biological materials |
EP0804255B1 (en) * | 1994-07-29 | 2001-10-04 | Edwards Lifesciences Corporation | Methods for treating implantable biological tissues to mitigate the calcification thereof |
US6214054B1 (en) | 1998-09-21 | 2001-04-10 | Edwards Lifesciences Corporation | Method for fixation of biological tissues having mitigated propensity for post-implantation calcification and thrombosis and bioprosthetic devices prepared thereby |
US6521179B1 (en) * | 1999-08-11 | 2003-02-18 | Biomedical Design, Inc. | Sterilization |
FR2800397B1 (en) * | 1999-10-27 | 2002-01-18 | Electrolux Syst Blanchisserie | METHOD FOR CONTROLLING THE ASEPTIC CHARACTERISTICS OF THE LAUNDRY BEFORE OPENING AT LEAST ONE WASHING MACHINE DOOR |
US6471723B1 (en) | 2000-01-10 | 2002-10-29 | St. Jude Medical, Inc. | Biocompatible prosthetic tissue |
US20040086420A1 (en) * | 2000-03-23 | 2004-05-06 | Macphee Martin J. | Methods for sterilizing serum or plasma |
AU2001259031B2 (en) * | 2000-03-23 | 2006-04-13 | Clearant, Inc. | Methods for sterilizing biological materials |
US20020177223A1 (en) * | 2001-03-12 | 2002-11-28 | Ogle Mathew F. | Methods and compositions for crosslinking tissue |
US6682695B2 (en) * | 2001-03-23 | 2004-01-27 | Clearant, Inc. | Methods for sterilizing biological materials by multiple rates |
US7078163B2 (en) * | 2001-03-30 | 2006-07-18 | Medtronic, Inc. | Process for reducing mineralization of tissue used in transplantation |
US6696060B2 (en) * | 2001-06-14 | 2004-02-24 | Clearant, Inc. | Methods for sterilizing preparations of monoclonal immunoglobulins |
US6946098B2 (en) | 2001-08-10 | 2005-09-20 | Clearant, Inc. | Methods for sterilizing biological materials |
US20030031584A1 (en) * | 2001-08-10 | 2003-02-13 | Wilson Burgess | Methods for sterilizing biological materials using dipeptide stabilizers |
US6749851B2 (en) * | 2001-08-31 | 2004-06-15 | Clearant, Inc. | Methods for sterilizing preparations of digestive enzymes |
US7252799B2 (en) * | 2001-08-31 | 2007-08-07 | Clearant, Inc. | Methods for sterilizing preparations containing albumin |
US20030185702A1 (en) * | 2002-02-01 | 2003-10-02 | Wilson Burgess | Methods for sterilizing tissue |
US20030068416A1 (en) * | 2001-09-24 | 2003-04-10 | Wilson Burgess | Method of lyophylization to reduce solvent content and enhance product recovery |
US20030095890A1 (en) * | 2001-09-24 | 2003-05-22 | Shirley Miekka | Methods for sterilizing biological materials containing non-aqueous solvents |
US20110091353A1 (en) * | 2001-09-24 | 2011-04-21 | Wilson Burgess | Methods for Sterilizing Tissue |
US6783968B2 (en) * | 2001-09-24 | 2004-08-31 | Clearant, Inc. | Methods for sterilizing preparations of glycosidases |
US20030124023A1 (en) * | 2001-12-21 | 2003-07-03 | Wilson Burgess | Method of sterilizing heart valves |
US6878168B2 (en) | 2002-01-03 | 2005-04-12 | Edwards Lifesciences Corporation | Treatment of bioprosthetic tissues to mitigate post implantation calcification |
US7918899B2 (en) | 2002-01-25 | 2011-04-05 | Biomedical Design, Inc. | Variably crosslinked tissue |
JP4512370B2 (en) * | 2002-01-25 | 2010-07-28 | バイオメディカル デザイン インコーポレイテッド | Anti-calcification fixation |
US20040013562A1 (en) * | 2002-07-18 | 2004-01-22 | Wilson Burgess | Methods for sterilizing milk. |
US20040013561A1 (en) * | 2002-07-18 | 2004-01-22 | David Mann | Methods for sterilizing recombinant or transgenic material |
US6908591B2 (en) * | 2002-07-18 | 2005-06-21 | Clearant, Inc. | Methods for sterilizing biological materials by irradiation over a temperature gradient |
US7955788B2 (en) * | 2003-10-30 | 2011-06-07 | Medtronic, Inc. | Bioprosthetic tissue preparation with synthetic hydrogels |
US20050266390A1 (en) * | 2004-06-01 | 2005-12-01 | Yuichiro Ueda | Processes for removing cells and cell debris from tissue and tissue constructs used in transplantation and tissue reconstruction |
US20070218038A1 (en) | 2006-03-17 | 2007-09-20 | Pegasus Biologics, Inc. | Stabilized, sterilized collagen scaffolds with active adjuncts attached |
WO2008073582A2 (en) | 2006-10-27 | 2008-06-19 | Edwards Lifesciences Corporation | Biological tissue for surgical implantation |
US9101691B2 (en) * | 2007-06-11 | 2015-08-11 | Edwards Lifesciences Corporation | Methods for pre-stressing and capping bioprosthetic tissue |
US20090018655A1 (en) * | 2007-07-13 | 2009-01-15 | John Brunelle | Composite Implant for Surgical Repair |
US8357387B2 (en) | 2007-12-21 | 2013-01-22 | Edwards Lifesciences Corporation | Capping bioprosthetic tissue to reduce calcification |
US9387280B2 (en) * | 2008-09-05 | 2016-07-12 | Synovis Orthopedic And Woundcare, Inc. | Device for soft tissue repair or replacement |
EP2674174B1 (en) | 2010-03-23 | 2019-10-16 | Edwards Lifesciences Corporation | Methods of conditioning sheet bioprosthetic tissue |
US8906601B2 (en) | 2010-06-17 | 2014-12-09 | Edwardss Lifesciences Corporation | Methods for stabilizing a bioprosthetic tissue by chemical modification of antigenic carbohydrates |
WO2012027515A2 (en) | 2010-08-24 | 2012-03-01 | Southern Lights Ventures 2002 Limited | Biomaterials with enhanced properties and devices made therefrom |
US9351829B2 (en) | 2010-11-17 | 2016-05-31 | Edwards Lifesciences Corporation | Double cross-linkage process to enhance post-implantation bioprosthetic tissue durability |
US10238771B2 (en) | 2012-11-08 | 2019-03-26 | Edwards Lifesciences Corporation | Methods for treating bioprosthetic tissue using a nucleophile/electrophile in a catalytic system |
US9615922B2 (en) | 2013-09-30 | 2017-04-11 | Edwards Lifesciences Corporation | Method and apparatus for preparing a contoured biological tissue |
US10959839B2 (en) | 2013-10-08 | 2021-03-30 | Edwards Lifesciences Corporation | Method for directing cellular migration patterns on a biological tissue |
CA3116158A1 (en) | 2018-11-01 | 2020-05-07 | Edwards Lifesciences Corporation | Transcatheter pulmonic regenerative valve |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0037381B1 (en) * | 1980-03-31 | 1984-10-17 | Solco Basel AG | Method of making organic grafts |
US4378224A (en) * | 1980-09-19 | 1983-03-29 | Nimni Marcel E | Coating for bioprosthetic device and method of making same |
EP0124596A4 (en) * | 1982-11-12 | 1985-06-26 | American Hospital Supply Corp | Chemical sterilization of implantable biological tissue. |
US4786287A (en) * | 1986-10-10 | 1988-11-22 | Baxter Travenol Laboratories | Process for decreasing residual aldehyde levels in implantable bioprosthetic tissue |
US5104405A (en) * | 1991-02-21 | 1992-04-14 | The University Of Southern California | Process for improving the biostability of tissue implant devices and bioprosthetic implants so produced |
US5447536A (en) * | 1994-02-17 | 1995-09-05 | Biomedical Design, Inc. | Method for fixation of biological tissue |
KR0131046B1 (en) * | 1994-07-13 | 1998-04-14 | 김은영 | Calcification-resistant tissue heart valve |
-
1998
- 1998-02-09 US US09/020,471 patent/US5911951A/en not_active Expired - Lifetime
- 1998-02-09 AU AU60567/98A patent/AU735988B2/en not_active Ceased
- 1998-02-09 DE DE69814070T patent/DE69814070T2/en not_active Expired - Lifetime
- 1998-02-09 JP JP53494998A patent/JP4271262B2/en not_active Expired - Fee Related
- 1998-02-09 CA CA002279625A patent/CA2279625C/en not_active Expired - Fee Related
- 1998-02-09 WO PCT/US1998/002395 patent/WO1998034650A2/en active IP Right Grant
- 1998-02-09 EP EP98903931A patent/EP0986405B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US5911951A (en) | 1999-06-15 |
AU6056798A (en) | 1998-08-26 |
EP0986405B1 (en) | 2003-05-02 |
WO1998034650A2 (en) | 1998-08-13 |
WO1998034650A3 (en) | 1998-10-01 |
JP2001512333A (en) | 2001-08-21 |
DE69814070T2 (en) | 2003-12-18 |
AU735988B2 (en) | 2001-07-26 |
JP4271262B2 (en) | 2009-06-03 |
EP0986405A2 (en) | 2000-03-22 |
CA2279625C (en) | 2008-01-29 |
DE69814070D1 (en) | 2003-06-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20170209 |