CA2278870A1 - Dosages d'analytes multiples dans le serum a partir de spectres dans l'ir moyen de feuils secs sur lame de verre - Google Patents
Dosages d'analytes multiples dans le serum a partir de spectres dans l'ir moyen de feuils secs sur lame de verre Download PDFInfo
- Publication number
- CA2278870A1 CA2278870A1 CA002278870A CA2278870A CA2278870A1 CA 2278870 A1 CA2278870 A1 CA 2278870A1 CA 002278870 A CA002278870 A CA 002278870A CA 2278870 A CA2278870 A CA 2278870A CA 2278870 A1 CA2278870 A1 CA 2278870A1
- Authority
- CA
- Canada
- Prior art keywords
- spectra
- mid
- serum
- spectroscopy
- assays
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000001228 spectrum Methods 0.000 title description 31
- 210000002966 serum Anatomy 0.000 title description 26
- 238000003556 assay Methods 0.000 title description 15
- 239000011521 glass Substances 0.000 title description 15
- 238000004458 analytical method Methods 0.000 description 28
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 25
- 230000009102 absorption Effects 0.000 description 20
- 238000010521 absorption reaction Methods 0.000 description 20
- 238000004476 mid-IR spectroscopy Methods 0.000 description 16
- 230000003595 spectral effect Effects 0.000 description 15
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 14
- 239000008103 glucose Substances 0.000 description 14
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 12
- 239000004202 carbamide Substances 0.000 description 12
- 235000012000 cholesterol Nutrition 0.000 description 12
- 102000004169 proteins and genes Human genes 0.000 description 12
- 108090000623 proteins and genes Proteins 0.000 description 12
- 239000000758 substrate Substances 0.000 description 12
- 102000009027 Albumins Human genes 0.000 description 11
- 238000012360 testing method Methods 0.000 description 11
- 108010088751 Albumins Proteins 0.000 description 10
- 230000008901 benefit Effects 0.000 description 10
- 238000002329 infrared spectrum Methods 0.000 description 9
- 238000000034 method Methods 0.000 description 9
- 238000004566 IR spectroscopy Methods 0.000 description 8
- 229910001632 barium fluoride Inorganic materials 0.000 description 8
- 150000003626 triacylglycerols Chemical class 0.000 description 8
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 7
- 241000894007 species Species 0.000 description 7
- 238000013459 approach Methods 0.000 description 6
- 239000012491 analyte Substances 0.000 description 5
- 238000000862 absorption spectrum Methods 0.000 description 4
- 230000005540 biological transmission Effects 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 238000010606 normalization Methods 0.000 description 4
- ZNNZYHKDIALBAK-UHFFFAOYSA-M potassium thiocyanate Chemical compound [K+].[S-]C#N ZNNZYHKDIALBAK-UHFFFAOYSA-M 0.000 description 4
- PVNIQBQSYATKKL-UHFFFAOYSA-N tripalmitin Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCC PVNIQBQSYATKKL-UHFFFAOYSA-N 0.000 description 4
- OYLGJCQECKOTOL-UHFFFAOYSA-L barium fluoride Chemical compound [F-].[F-].[Ba+2] OYLGJCQECKOTOL-UHFFFAOYSA-L 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 238000012549 training Methods 0.000 description 3
- 238000002235 transmission spectroscopy Methods 0.000 description 3
- 238000010200 validation analysis Methods 0.000 description 3
- 108010071390 Serum Albumin Proteins 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 229940109239 creatinine Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 2
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 2
- 229960001947 tripalmitin Drugs 0.000 description 2
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 101001065501 Escherichia phage MS2 Lysis protein Proteins 0.000 description 1
- 102000004895 Lipoproteins Human genes 0.000 description 1
- 108090001030 Lipoproteins Proteins 0.000 description 1
- 102000007562 Serum Albumin Human genes 0.000 description 1
- ZMZDMBWJUHKJPS-UHFFFAOYSA-M Thiocyanate anion Chemical compound [S-]C#N ZMZDMBWJUHKJPS-UHFFFAOYSA-M 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 210000004381 amniotic fluid Anatomy 0.000 description 1
- 238000004164 analytical calibration Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000001311 chemical methods and process Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 238000009795 derivation Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- ZMZDMBWJUHKJPS-UHFFFAOYSA-N hydrogen thiocyanate Natural products SC#N ZMZDMBWJUHKJPS-UHFFFAOYSA-N 0.000 description 1
- 238000012623 in vivo measurement Methods 0.000 description 1
- 238000002188 infrared transmission spectroscopy Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 238000012417 linear regression Methods 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 125000001434 methanylylidene group Chemical group [H]C#[*] 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 238000010238 partial least squares regression Methods 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 238000012123 point-of-care testing Methods 0.000 description 1
- 229940116357 potassium thiocyanate Drugs 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000007781 pre-processing Methods 0.000 description 1
- 238000012207 quantitative assay Methods 0.000 description 1
- 238000012950 reanalysis Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N21/359—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Pathology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002278870A CA2278870A1 (fr) | 1999-07-26 | 1999-07-26 | Dosages d'analytes multiples dans le serum a partir de spectres dans l'ir moyen de feuils secs sur lame de verre |
PCT/CA2000/000864 WO2001007894A1 (fr) | 1999-07-26 | 2000-07-24 | Analyse de fluides biologiques |
AU64182/00A AU6418200A (en) | 1999-07-26 | 2000-07-24 | Analysis of biological fluids |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002278870A CA2278870A1 (fr) | 1999-07-26 | 1999-07-26 | Dosages d'analytes multiples dans le serum a partir de spectres dans l'ir moyen de feuils secs sur lame de verre |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2278870A1 true CA2278870A1 (fr) | 2001-01-26 |
Family
ID=4163829
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002278870A Abandoned CA2278870A1 (fr) | 1999-07-26 | 1999-07-26 | Dosages d'analytes multiples dans le serum a partir de spectres dans l'ir moyen de feuils secs sur lame de verre |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU6418200A (fr) |
CA (1) | CA2278870A1 (fr) |
WO (1) | WO2001007894A1 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104458647A (zh) * | 2014-12-10 | 2015-03-25 | 华润三九医药股份有限公司 | 利用近红外光谱在线检测复方醋酸地塞米松乳膏的方法 |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003042948A (ja) * | 2001-08-03 | 2003-02-13 | Univ Waseda | グルコース濃度測定装置 |
WO2003023397A1 (fr) * | 2001-09-12 | 2003-03-20 | National Research Council Of Canada | Methode pour la determination simultanee et directe du cholesterol serique dans les lipoproteines de haute et de basse densite au moyen d'une spectroscopie infrarouge |
ES2396106B1 (es) * | 2011-08-08 | 2014-06-06 | Consejo Superior De Investigaciones Científicas (Csic) | Análisis infrarrojo de fracciones de sangre periférica obtenida para indicar desarrollo cognitivo asociado a la enfermedad de alzheimer. |
ES2774983B2 (es) | 2019-01-22 | 2021-06-10 | Univ Sevilla | Dispositivo portable y metodo para la estimacion no invasiva del nivel de glucosa en sangre |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997011365A1 (fr) * | 1995-09-20 | 1997-03-27 | Coretech Medical Technologies Corporation | Analyse de la permeabilite pulmonaire |
US6285448B1 (en) * | 1997-05-05 | 2001-09-04 | J. Todd Kuenstner | Clinical analyte determination by infrared spectroscopy |
-
1999
- 1999-07-26 CA CA002278870A patent/CA2278870A1/fr not_active Abandoned
-
2000
- 2000-07-24 AU AU64182/00A patent/AU6418200A/en not_active Abandoned
- 2000-07-24 WO PCT/CA2000/000864 patent/WO2001007894A1/fr active Application Filing
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104458647A (zh) * | 2014-12-10 | 2015-03-25 | 华润三九医药股份有限公司 | 利用近红外光谱在线检测复方醋酸地塞米松乳膏的方法 |
Also Published As
Publication number | Publication date |
---|---|
AU6418200A (en) | 2001-02-13 |
WO2001007894A1 (fr) | 2001-02-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |