CA2274955A1 - Procede pour diagnostiquer et traiter des troubles pathologiques lies a une insuffisance du transport d'ions - Google Patents

Procede pour diagnostiquer et traiter des troubles pathologiques lies a une insuffisance du transport d'ions Download PDF

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Publication number
CA2274955A1
CA2274955A1 CA002274955A CA2274955A CA2274955A1 CA 2274955 A1 CA2274955 A1 CA 2274955A1 CA 002274955 A CA002274955 A CA 002274955A CA 2274955 A CA2274955 A CA 2274955A CA 2274955 A1 CA2274955 A1 CA 2274955A1
Authority
CA
Canada
Prior art keywords
protein
tsc
nkcc2
romk
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002274955A
Other languages
English (en)
Inventor
Richard P. Lifton
David B. Simon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yale University
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2274955A1 publication Critical patent/CA2274955A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/34—Genitourinary disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La présente invention concerne, pour partie, l'identification des rôles du co-transporteur de Na-Cl, sensible aux composés thiazidiques, d'origine humaine, le TSC; du canal K?+¿ sensible à l'ATP d'origine humaine, le ROMK; et du co-transporteur de Na-K-2Cl d'origine humaine, le NKCC2, s'agissant de la création d'un trouble pathologique associé à un transport d'ions anormal, notamment dans le syndrome de Bartter, le syndrome de Gitelman, l'alcalose hypokaliémique, l'alcalose hypokaliémique avec hypercalciurie, les calculs rénaux, l'hypertension artérielle, l'ostéoporose et la sensibilité à l'hyperkaliémie induite par diurétique. La présente invention se rapporte spécifiquement à la séquence d'acides aminés de plusieurs allèles modifiés ou du type sauvage, d'origine humaine, des protéines TSC, NKCC2 et ROMK ainsi qu'à la séquence nucléotidique qui code ces allèles pouvant servir au diagnostic des troubles liés au transport d'ions.
CA002274955A 1996-12-31 1997-12-19 Procede pour diagnostiquer et traiter des troubles pathologiques lies a une insuffisance du transport d'ions Abandoned CA2274955A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US77805296A 1996-12-31 1996-12-31
US08/778,052 1996-12-31
PCT/US1997/023553 WO1998029431A1 (fr) 1996-12-31 1997-12-19 Procede pour diagnostiquer et traiter des troubles pathologiques lies a une insuffisance du transport d'ions

Publications (1)

Publication Number Publication Date
CA2274955A1 true CA2274955A1 (fr) 1998-07-09

Family

ID=25112171

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002274955A Abandoned CA2274955A1 (fr) 1996-12-31 1997-12-19 Procede pour diagnostiquer et traiter des troubles pathologiques lies a une insuffisance du transport d'ions

Country Status (5)

Country Link
EP (1) EP1030858A1 (fr)
JP (1) JP2001508291A (fr)
AU (1) AU746220B2 (fr)
CA (1) CA2274955A1 (fr)
WO (1) WO1998029431A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5989861A (en) * 1998-07-22 1999-11-23 Incyte Pharmaceuticals, Inc. Human ion transport-like protein
EP1276893A4 (fr) 2000-04-14 2005-05-04 Univ Vanderbilt Acides nucleiques et poypeptides purifies et isoles cotransporteurs de chlorure de potassium
WO2002080842A2 (fr) * 2001-04-05 2002-10-17 Estetecon Ab Medicament et procede de diagnostic d'un etat auto-immun
JP6586684B2 (ja) * 2015-11-11 2019-10-09 島根県 ウシ胎子の胎膜水腫の発症しやすさを判定する方法及びウシの胎膜水腫のキャリアを特定する方法

Also Published As

Publication number Publication date
AU6013598A (en) 1998-07-31
WO1998029431A1 (fr) 1998-07-09
JP2001508291A (ja) 2001-06-26
AU746220B2 (en) 2002-04-18
EP1030858A1 (fr) 2000-08-30

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Legal Events

Date Code Title Description
FZDE Discontinued