CA2274116A1 - Utilisations de thioredoxine - Google Patents
Utilisations de thioredoxine Download PDFInfo
- Publication number
- CA2274116A1 CA2274116A1 CA002274116A CA2274116A CA2274116A1 CA 2274116 A1 CA2274116 A1 CA 2274116A1 CA 002274116 A CA002274116 A CA 002274116A CA 2274116 A CA2274116 A CA 2274116A CA 2274116 A1 CA2274116 A1 CA 2274116A1
- Authority
- CA
- Canada
- Prior art keywords
- thioredoxin
- inhibitor
- tumor growth
- inhibiting tumor
- agents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000002933 Thioredoxin Human genes 0.000 title abstract 4
- 229940094937 thioredoxin Drugs 0.000 title abstract 4
- 108060008226 thioredoxin Proteins 0.000 title abstract 4
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 230000004614 tumor growth Effects 0.000 title 1
- 230000010261 cell growth Effects 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 230000006907 apoptotic process Effects 0.000 abstract 1
- 239000003324 growth hormone secretagogue Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3199596P | 1996-12-06 | 1996-12-06 | |
US60/031,995 | 1996-12-06 | ||
PCT/US1997/022292 WO1998024472A1 (fr) | 1996-12-06 | 1997-12-05 | Utilisations de thioredoxine |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2274116A1 true CA2274116A1 (fr) | 1998-06-11 |
CA2274116C CA2274116C (fr) | 2009-05-05 |
Family
ID=21862543
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002274116A Expired - Fee Related CA2274116C (fr) | 1996-12-06 | 1997-12-05 | Utilisations de thioredoxine |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP0946192A1 (fr) |
CA (1) | CA2274116C (fr) |
WO (1) | WO1998024472A1 (fr) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6552060B1 (en) | 1997-08-11 | 2003-04-22 | Prolx Pharmaceuticals, Inc. | Asymmetric disulfides and methods of using same |
US6372772B1 (en) | 1997-08-01 | 2002-04-16 | Prolx Pharmaceuticals Corporation | Inhibitors of redox signaling and methods of using same |
CN1302107C (zh) | 1998-01-30 | 2007-02-28 | 吉倪塞思技术公司 | 与硫氧还蛋白或硫氧还蛋白还原酶基因互补的寡核苷酸序列以及将其用于调节细胞生长的方法 |
WO2004013283A2 (fr) * | 2002-08-02 | 2004-02-12 | University Of Rochester | Mutants de thioredoxine et leur utilisation |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE8903003D0 (sv) * | 1989-09-12 | 1989-09-12 | Astra Ab | Novel medical use |
-
1997
- 1997-12-05 WO PCT/US1997/022292 patent/WO1998024472A1/fr not_active Application Discontinuation
- 1997-12-05 EP EP97952292A patent/EP0946192A1/fr not_active Withdrawn
- 1997-12-05 CA CA002274116A patent/CA2274116C/fr not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2274116C (fr) | 2009-05-05 |
EP0946192A1 (fr) | 1999-10-06 |
WO1998024472A1 (fr) | 1998-06-11 |
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CA2274116A1 (fr) | Utilisations de thioredoxine |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |